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纳米金属复合物的生物识别控制实现靶向多模态诊疗
来源于:Chemical Science | 作者:纳米医学网 | 发布时间:2017-04-09 | 浏览:2131

    

   来自华东理工大学、中科院上海药物所和英国巴斯大学的研究团队以荧光标记的糖配体与环糊精修饰的金纳米以超分子组装形成的金属纳米复合物,它具有使用两个不同的荧光机制:福斯特共振能量转移(FRET)和金属增强荧光(MEF),并通过配体-受体相互作用实现控制。荧光团至颗粒近端产生FRET猝灭荧光。随后,特异性蛋白受体相互作用导致复合材料的聚集,激活由远端金属颗粒到聚集体间的MEF荧光。聚集还可以启动复合材料的吸光度的红移,从而提高生产活性氧(ROS)来发射红光。该纳米复合物已被证明适用于有针对性的癌细胞成像,还可通过光动力和药物传递性能实现多模态治疗。



        



报道刊物:Chemical Science (IF=9.0)2016, 7, 4004-4008. DOI:10.1039/C6SC01463A

论文作者:Xi-Le Hu,  Yi Zang,  Jia Li,  Guo-Rong Chen,  Tony D. James,  Xiao-Peng He,  He Tian



Abstract

We have developed a theranostic nanocomposite of metallic nanoparticles that uses two distinct fluorescence mechanisms: Förster Resonance Energy Transfer (FRET) and Metal-Enhanced Fluorescence (MEF) controlled by ligand–receptor interaction. Supramolecular assembly of the fluorophore-labeled glycoligands to cyclodextrin-capped gold nanoparticles produces a nanocomposite with a quenched fluorescence due to FRET from the fluorophore to the proximal particle. Subsequently, interaction with a selective protein receptor leads to an aggregation of the composite, reactivating the fluorescence by MEF from the distal metallic particles to fluorophores encapsulated in the aggregates. The aggregation also causes a red-shift in absorbance of the composite, thereby enhancing the production of reactive oxygen species (ROS) on red-light irradiation. Our nanocomposite has proven suitable for targeted cancer cell imaging as well as multimode therapy using both the photodynamic and drug delivery properties of the composite.


 
 
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