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2018年生物纳米研究经典报道(四)
来源于:纳米医学网 | 作者: | 发布时间:2017-10-26 | 浏览:419




Nanoparticle Gradient Materials by Centrifugation
Small (IF 10.856) Pub Date : 2018-11-06 ,DOI:10.1002/smll.201803518
Andreas Spinnrock; David Schupp; Helmut Cölfen
Nanoparticle gradient materials are a unique class of functional materials. They combine the specific properties of nanoparticles with macroscopic materials. A continuous spatial gradient of the nanoparticleconcentration leads to diverse physical property profiles. ...
Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models
Journal of Controlled Release (IF 7.901) Pub Date : 2018-04-21 ,DOI:
Einar Sulheim, Jana Kim, Annemieke van Wamel, Eugene Kim, Sofie Snipstad, Igor Vidic, Ingeborg Hovde Grimstad, Marius Widerøe, Sverre H. Torp, Steinar Lundgren, David J. Waxman, Catharina de Lange Davies
Nanoparticle uptake and distribution in the tumors were generally heterogeneous. ...
Exosomal miRNA Profiling to Identify Nanoparticle Phagocytic Mechanisms
Small (IF 10.856) Pub Date : 2018-03-08 ,DOI:10.1002/smll.201704008
Lin Zhang; Changfu Hao; Sanqiao Yao; Rong Tang; Wei Guo; Hongbin Cong; Jiangfeng Li; Lei Bao; Di Wang; Yiping Li; Xinghao Yu; Shuyin Duan; Wu Yao
Specially, the assumption is further confirmed via a series of cellular experiments, and the fibroblast transdifferentiate rate that is used as an indicator of nanoparticle phagocytosis decreased when elevating miRNA expression level. ...
Protein Coronas: Beyond Global Charge: Role of Amine Bulkiness and Protein Fingerprint on Nanoparticle–Cell Interaction (Small 46/2018)
Small (IF 10.856) Pub Date : 2018-11-15 ,DOI:10.1002/smll.201870213
David Burnand; Ana Milosevic; Sandor Balog; Miguel Spuch‐Calvar; Barbara Rothen‐Rutishauser; Jörn Dengjel; Calum Kinnear; Thomas L. Moore; Alke Petri‐Fink
Nanoparticle surface chemistry is a key component for nanoparticle‐cell interactions. Positively charged amines are hypothesized to drive these via Coulombic interactions with a negatively charged cell membrane. In article number 1802088, Calum Kinnear, Thomas L. ...
Paradox of PEGylation in fabricating hybrid nanoparticle-based nicotine vaccines
Biomaterials (IF 10.273) Pub Date : 2018-08-07 ,DOI:10.1016/j.biomaterials.2018.08.015
Yun Hu, Zongmin Zhao, Theresa Harmon, Paul R. Pentel, Marion Ehrich, Chenming Zhang
It was found that 30% PEGylation resulted in a hybrid nanoparticle of a compromised core-shell structure. A higher concentration of PEG also led to a slower cellular uptake of hybrid nanoparticles by dendritic cells. ...
Noninvasive monitoring of nanoparticle clearance and aggregation in blood circulation by in vivo flow cytometry
Journal of Controlled Release (IF 7.901) Pub Date : 2018-04-03 ,DOI:10.1016/j.jconrel.2018.03.024
Dan Wei, Kai Pang, Qingxiang Song, Yuanzhen Suo, Hao He, Xiaofu Weng, Xiaoling Gao, Xunbin Wei
In addition, formation of nanoparticle aggregates is a key determinant for biocompatibility and drug delivery efficiency. ...
Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics
Biomaterials (IF 10.273) Pub Date : 2018-11-21 ,DOI:10.1016/j.biomaterials.2018.11.028
Svenja Siemer, Dana Westmeier, Matthias Barz, Jonas Eckrich, Désirée Wünsch, Christof Seckert, Christian Thyssen, Oliver Schilling, Mike Hasenberg, Chengfan Pang, Dominic Docter, Shirley K. Knauer, Roland H. Stauber, Sebastian Strieth
Using controllable nanoparticle models, we found that nanoparticle-pathogen complex formation was enhanced by small nanoparticle size rather than material or charge, and was prevented by 'stealth' modifications. ...
Self‐Assembly of CoPt Magnetic Nanoparticle Arrays and its Underlying Forces
Small (IF 10.856) Pub Date : 29 July 20 ,DOI:10.1002/smll.201801184
Baoru Bian; Guoxin Chen; Qiang Zheng; Juan Du; Huanming Lu; J. Ping Liu; Yong Hu; Zhidong Zhang
This investigation leads to a better understanding of the formation mechanism of magnetic nanoparticlesuperlattice arrays. ...
Co-delivery nanoparticle to overcome metastasis promoted by insufficient chemotherapy
Journal of Controlled Release (IF 7.901) Pub Date : 2018-02-19 ,DOI:10.1016/j.jconrel.2018.02.026
Qing Zhou, Yihui Li, Yanhong Zhu, Chan Yu, Haibo Jia, Binghao Bao, Hang Hu, Chen Xiao, Jianqi Zhang, Xiaofan Zeng, Ying Wan, Huibi Xu, Zifu Li, Xiangliang Yang
Further study on immunofluorescence images of primary tumor verifies that low dose of DOX exasperates the EMT process, whereas the co-delivery nanoparticle can dramatically inhibit the progression of EMT. ...
Analytical Ultracentrifugation: Nanoparticle Gradient Materials by Centrifugation (Small 50/2018)
Small (IF 10.856) Pub Date : 2018-12-13 ,DOI:10.1002/smll.201870244
Andreas Spinnrock; David Schupp; Helmut Cölfen
In article number 1803518, Helmut Cölfen and co‐workers use analytical ultracentrifugation to fabricate tailored nanoparticle gradient materials. ...
Beyond Global Charge: Role of Amine Bulkiness and Protein Fingerprint on Nanoparticle–Cell Interaction
Small (IF 10.856) Pub Date : 2018-09-10 ,DOI:10.1002/smll.201802088
David Burnand; Ana Milosevic; Sandor Balog; Miguel Spuch‐Calvar; Barbara Rothen‐Rutishauser; Jörn Dengjel; Calum Kinnear; Thomas L. Moore; Alke Petri‐Fink
By evaluating the nanoparticle surface chemistry and the protein fingerprint, proteins that are significant in mediating particle–cell association are identified. ...
Spray‐Dried Nanoparticle‐in‐Microparticle Delivery Systems (NiMDS) for Gene Delivery, Comprising Polyethylenimine (PEI)‐Based Nanoparticles in a Poly(Vinyl Alcohol) Matrix
Small (IF 10.856) Pub Date : 2018-02-12 ,DOI:10.1002/smll.201701810
Jan Schulze; Stephanie Kuhn; Stephan Hendrikx; Michaela Schulz‐Siegmund; Tobias Polte; Achim Aigner
This easy‐to‐handle gene delivery device allows prolonged nanoparticle storage and protection at ambient temperature. ...
Single Nanoparticle Magnetic Spin Memristor
Small (IF 10.856) Pub Date : 27 June 20 ,DOI:10.1002/smll.201801249
Hammam Al‐Bustami; Guy Koplovitz; Darinka Primc; Shira Yochelis; Eyal Capua; Danny Porath; Ron Naaman; Yossi Paltiel
A single nanoparticle, along with Au contacts and chiral molecules, is sufficient to function as a memory device. A single ferromagnetic nanoplatelet is used as a fixed hard magnet combined with Au contacts in which the gold contacts act as soft magnets due to the adsorbed chiral molecules. ...
Artificial Synapses: Biological Spiking Synapse Constructed from Solution Processed Bimetal Core–Shell Nanoparticle Based Composites (Small 28/2018)
Small (IF 10.856) Pub Date : 2018-07-12 ,DOI:10.1002/smll.201870128
Li Zhou; Jing‐Yu Mao; Yi Ren; Jia‐Qin Yang; Shi‐Rui Zhang; Ye Zhou; Qiufan Liao; Yu‐Jia Zeng; Haiquan Shan; Zongxiang Xu; Jingjing Fu; Yan Wang; Xiaoli Chen; Ziyu Lv; Su‐Ting Han; Vellaisamy A. L. Roy
Roy, and co‐workers develop a biological spiking synaptic device with important synaptic behaviors constructed from solution processed bimetal core‐shell nanoparticle based composites. ...
Optoacoustic imaging identifies ovarian cancer using a microenvironment targeted theranostic wormhole mesoporous silica nanoparticle
Biomaterials (IF 10.273) Pub Date : 2018-08-04 ,DOI:10.1016/j.biomaterials.2018.08.001
Abhilash Samykutty, William E. Grizzle, Benjamin L. Fouts, Molly W. McNally, Phillip Chuong, Alexandra Thomas, Akiko Chiba, Dennis Otali, Anna Woloszynska, Neveen Said, Peter J. Frederick, Jacek Jasinski, Jie Liu, Lacey R. McNally
An acidic pH targeted wormhole mesoporous silica nanoparticle (V7-RUBY) was developed to serve as a novel tumor specific theranostic nanoparticle detectable using multispectral optoacoustic tomographic (MSOT) imaging. ...
Freeze the Moment: High Speed Capturing of Weakly Bonded Dynamic Nanoparticle Assemblies in Solution by Ag Ion Soldering
Small (IF 10.856) Pub Date : 2018-01-09 ,DOI:10.1002/smll.201703303
Yueliang Wang, Lingling Fang, Gaoli Chen, Lei Song, Zhaoxiang Deng
This method works efficiently for both solid (3D) nanoparticle aggregates and weakly bonded fractal nanoparticle chains (1D). In both cases, very high capturing speed and close to 100% efficiency are achieved to fully retain a quickly growing structure. ...
Voltage‐Gated Nanoparticle Transport and Collisions in Attoliter‐Volume Nanopore Electrode Arrays
Small (IF 10.856) Pub Date : 2018-01-29 ,DOI:10.1002/smll.201703248
Kaiyu Fu; Donghoon Han; Garrison M. Crouch; Seung‐Ryong Kwon; Paul W. Bohn
Single nanoparticle analysis can reveal how particle‐to‐particle heterogeneity affects ensemble properties derived from traditional bulk measurements. ...
A Novel Self‐Assembled Mitochondria‐Targeting Protein Nanoparticle Acting as Theranostic Platform for Cancer
Small (IF 10.856) Pub Date : 2018-11-19 ,DOI:10.1002/smll.201803428
Xin‐Jie Zhu; Ri‐Fei Li; Liang Xu; Hui Yin; Long Chen; Ye Yuan; Wu Zhong; Jian Lin
To the best of the authors' knowledge, GST‐MT‐3 is the first reported protein nanoparticle that targets mitochondria. It has the potential to be an excellent platform for combination therapies. ...
Size‐Controlled Nanoparticle Assembly: Size‐Controlled Nanoparticle Clusters of Narrow Size‐Polydispersity Formed Using Multiple Particle Types Through Competitive Stabilizer Desorption to a Liquid–Liquid Interface (Small 44/2018)
Small (IF 10.856) Pub Date : 2018-11-05 ,DOI:10.1002/smll.201870205
Eoin K. Fox; Fadwa El Haddassi; Jose Hierrezuelo; Tsedev Ninjbadgar; Jacek K. Stolarczyk; Jenny Merlin; Dermot F. Brougham
Brougham and co‐workers prepare suspensions of magnetic iron oxide nanoparticle assemblies in chloroform through a gradual process in which the size distribution narrows over time. ...
Biological Spiking Synapse Constructed from Solution Processed Bimetal Core–Shell Nanoparticle Based Composites
Small (IF 10.856) Pub Date : 27 May 201 ,DOI:10.1002/smll.201800288
Li Zhou; Jing‐Yu Mao; Yi Ren; Jia‐Qin Yang; Shi‐Rui Zhang; Ye Zhou; Qiufan Liao; Yu‐Jia Zeng; Haiquan Shan; Zongxiang Xu; Jingjing Fu; Yan Wang; Xiaoli Chen; Ziyu Lv; Su‐Ting Han; Vellaisamy A. L. Roy
In this work, a biological spiking synapse is developed with solution processed Au@Ag core–shell nanoparticle (NP)‐based RRAM. ...
Nanoparticle uptake by circulating leukocytes: A major barrier to tumor delivery
Journal of Controlled Release (IF 7.901) Pub Date : 2018-07-17 ,DOI:10.1016/j.jconrel.2018.07.031
Jamie L. Betker, Dallas Jones, Christine R. Childs, Karen M. Helm, Kristina Terrell, Maria A. Nagel, Thomas J. Anchordoquy
However, our studies suggest that this relationship is not straightforward, and that particle sequestration by leukocytes can significantly alter biodistribution, especially with non-PEGylated nanoparticleformulations. ...
Engineering nanoparticle strategies for effective cancer immunotherapy
Biomaterials (IF 10.273) Pub Date : 2018-03-21 ,DOI:10.1016/j.biomaterials.2018.03.036
Hong Yeol Yoon, Subramanian Tamil Selvan, Yoosoo Yang, Min Ju Kim, Dong Kee Yi, Ick Chan Kwon, Kwangmeyung Kim
Theranostic nanoparticle system may one of key technology to address these issues by offering targeted delivery of various types of immunotherapeutics, resulting in significant improvements in the tumor immunotherapy. ...
Design Rules for Template‐Confined DNA‐Mediated Nanoparticle Assembly
Small (IF 10.856) Pub Date : 2018-09-24 ,DOI:10.1002/smll.201802742
Wenjie Zhou; Qing‐Yuan Lin; Jarad A. Mason; Vinayak P. Dravid; Chad A. Mirkin
Template‐based strategies are becoming increasingly important for controlling the position of nanoparticle‐based (NP‐based) structures on surfaces for a wide variety of encoding and device fabrication strategies. ...
Bioimaging: Dual‐Modal NIR‐Fluorophore Conjugated Magnetic Nanoparticle for Imaging Amyloid‐β Species In Vivo (Small 28/2018)
Small (IF 10.856) Pub Date : 2018-07-12 ,DOI:10.1002/smll.201870130
Yinhui Li; Di Xu; Hei‐Nga Chan; Chung‐Yan Poon; See‐Lok Ho; Hung‐Wing Li; Man Shing Wong
This nanoparticle‐based probe is not only non‐radiative and non‐toxic, but also highly blood brain barrier permeable and neuroprotective against Aβ induced toxicities, suggesting a great potential for early detection and diagnosis of Alzheimer's disease in humans. ...
Monitoring the Dynamic Process of Formation of Plasmonic Molecular Junctions during Single Nanoparticle Collisions
Small (IF 10.856) Pub Date : 2018-03-01 ,DOI:10.1002/smll.201704164
Jing Guo; Jie Pan; Shuai Chang; Xuewen Wang; Na Kong; Wenrong Yang; Jin He
Here, a facile method to form plasmonic molecular junctions is reported by utilizing single gold nanoparticle (NP) collision events at a highly curved gold nanoelectrode modified with a self‐assembled monolayer. ...
Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences
Journal of Controlled Release (IF 7.901) Pub Date : 2018-07-06 ,DOI:10.1016/j.jconrel.2018.07.011
Chih Kit Chung, C.G. Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
A powerful nanoparticle combination immunotherapy conferring durable therapeutic benefit whilst leaving healthy tissue untouched represents the base for more efficient post-surgical cancer treatment. ...
Mussel-inspired degradable antibacterial polydopamine/silica nanoparticle for rapid hemostasis
Biomaterials (IF 10.273) Pub Date : 2018-06-26 ,DOI:10.1016/j.biomaterials.2018.06.037
Chunyu Liu, Weihe Yao, Meng Tian, Junnan Wei, Qiling Song, Weihong Qiao
Herein, a silica nanoparticle coated with polydopamine (PDA/SiNP) with good degradability, antibacterial performance was developed for hemorrhage control. ...
Pharmacokinetic evaluation of liposomal nanoparticle-encapsulated nucleic acid drug: A combined study of dynamic PET imaging and LC/MS/MS analysis
Journal of Controlled Release (IF 7.901) Pub Date : 2018-12-07 ,DOI:10.1016/j.jconrel.2018.12.006
Hidefumi Mukai, Kentaro Hatanaka, Nobuhiro Yagi, Shota Warashina, Maki Zouda, Maiko Takahashi, Kazuya Narushima, Hayato Yabuuchi, Junko Iwano, Takeshi Kuboyama, Junichi Enokizono, Yasuhiro Wada, Yasuyoshi Watanabe
A combined approach of dynamic PET imaging and LC/MS/MS analysis will assist the development of nanoparticle-encapsulated nucleic acid drugs, such as those using WSs, to determine their detailed pharmacokinetics. ...
A Flexible Caterpillar‐Like Gold Nanoparticle Assemblies with Ultrasmall Nanogaps for Enhanced Dual‐Modal Imaging and Photothermal Therapy
Small (IF 10.856) Pub Date : 2018-04-14 ,DOI:10.1002/smll.201800094
Yuanzhi Xia; Xuehua Ma; Junhua Gao; Guoxin Chen; Zihou Li; Xiaoxia Wu; Zhangsen Yu; Jie Xing; Li Sun; Huimin Ruan; Lijia Luo; Lingchao Xiang; Chen Dong; Wenzhi Ren; Zheyu Shen; Aiguo Wu
Gold nanoparticle (AuNP) assemblies (GNAs) have attracted attention since enhanced coupling plasmonic resonance (CPR) emerged in the nanogap between coupling AuNPs. ...
Size‐Controlled Nanoparticle Clusters of Narrow Size‐Polydispersity Formed Using Multiple Particle Types Through Competitive Stabilizer Desorption to a Liquid–Liquid Interface
Small (IF 10.856) Pub Date : 2018-09-14 ,DOI:10.1002/smll.201802278
Eoin K. Fox; Fadwa El Haddassi; Jose Hierrezuelo; Tsedev Ninjbadgar; Jacek K. Stolarczyk; Jenny Merlin; Dermot F. Brougham
A novel colloidal approach is presented for preparing fully dispersed nanoparticle (NP) assemblies (clusters) of narrow size‐polydispersity over a wide range of sizes through irreversible depletion of stabilizing ligands onto a liquid–liquid interface. ...
Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation
Biomaterials (IF 10.273) Pub Date : 2018-10-25 ,DOI:10.1016/j.biomaterials.2018.10.031
Inès Mottas, Ahmet Bekdemir, Alessandra Cereghetti, Lorenzo Spagnuolo, Yu-Sang Sabrina Yang, Marie Müller, Darrell J. Irvine, Francesco Stellacci, Carole Bourquin
Thus, we demonstrate for the first time that nanoparticle delivery of a TLR7 immunostimulant to the tumor-draining lymph nodes enhances antitumor immunity and improves the outcome of cancer immunotherapy. ...
Sequestering and inhibiting a vascular endothelial growth factor in vivo by systemic administration of a synthetic polymer nanoparticle
Journal of Controlled Release (IF 7.901) Pub Date : 2018-12-20 ,DOI:10.1016/j.jconrel.2018.12.033
Hiroyuki Koide, Keiichi Yoshimatsu, Yu Hoshino, Saki Ariizumi, Anna Okishima, Takafumi Ide, Hiromichi Egami, Yoshitaka Hamashima, Yuri Nishimura, Hiroaki Kanazawa, Yoshiko Miura, Tomohiro Asai, Naoto Oku, Kenneth J. Shea
We demonstrate for the first time that an abiotic copolymer hydrogel nanoparticle (NP1) engineered to bind a key signaling protein, vascular endothelial growth factor (VEGF165), functions in vivo to suppress tumor growth by regulating angiogenesis. ...
Bifunctional Au@Bi2Se3 Core–Shell Nanoparticle for Synergetic Therapy by SERS‐Traceable AntagomiR Delivery and Photothermal Treatment
Small (IF 10.856) Pub Date : 2018-08-23 ,DOI:10.1002/smll.201802934
Mohsen Mohammadniaei; Taek Lee; Bapurao G. Bharate; Jinho Yoon; Hye Kyu Choi; Soo‐jeong Park; Junghoon Kim; Jungho Kim; Jeong‐Woo Choi
This selective PTT nanoparticle can also efficiently target solid tumors and undergo in vivo PTT, indicating its potential clinical applications. ...
Transparent, Flexible, Conformal Capacitive Pressure Sensors with Nanoparticles
Small (IF 10.856) Pub Date : 2018-01-26 ,DOI:10.1002/smll.201703432
Hyeohn Kim, Gwangmook Kim, Taehoon Kim, Sangwoo Lee, Donyoung Kang, Min-Soo Hwang, Youngcheol Chae, Shinill Kang, Hyungsuk Lee, Hong-Gyu Park, Wooyoung Shim
We utilize two nanoparticle dispersion states on a surface: (i) homogeneous dispersion, where each nanoparticle (≈500 nm) with a size comparable to the visible light wavelength has low light scattering; and (ii) heterogeneous dispersion, where aggregated nanoparticles form a micrometer-sized feature, ...
Enhanced cancer therapy with cold-controlled drug release and photothermal warming enabled with one nanoplatform
Biomaterials (IF 10.273) Pub Date : 2018-07-17 ,DOI:10.1016/j.biomaterials.2018.07.021
Hai Wang, Pranay Agarwal, Yutong Liang, Jiangsheng Xu, Gang Zhao, Katherine H.R. Tkaczuk, Xiongbin Lu, Xiaoming He
Here we developed a cold-responsive nanoparticle for controlled drug release as a result of the irreversible disassembly of the nanoparticle when cooled to below ∼10 °C. ...
Rational Design Principles for the Transport and Subcellular Distribution of Nanomaterials into Plant Protoplasts
Small (IF 10.856) Pub Date : 2018-09-06 ,DOI:10.1002/smll.201802086
Tedrick Thomas Salim Lew; Min Hao Wong; Seon‐Yeong Kwak; Rosalie Sinclair; Volodymyr B. Koman; Michael S. Strano
However, the mechanism of nanoparticle transport past plant biological membranes is poorly understood. Here, a mechanistic study of nanoparticle cellular uptake into plant protoplasts is presented. ...
Parallel Fabrication of Self‐Assembled Nanogaps for Molecular Electronic Devices
Small (IF 10.856) Pub Date : 2018-10-25 ,DOI:10.1002/smll.201803471
Johnas Eklöf‐Österberg; Tina Gschneidtner; Behabitu Tebikachew; Samuel Lara‐Avila; Kasper Moth‐Poulsen
Moreover, such assembly process results in an electrode–nanoparticle interface free from linking molecules that enable electrical measurements to probe electron transport properties of the nanoparticle–molecule–nanoparticle protodevices. ...
Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft
Journal of Controlled Release (IF 7.901) Pub Date : 2018-12-04 ,DOI:10.1016/j.jconrel.2018.11.029
Markus Fusser, Anders Øverbye, Abhilash D. Pandya, Ýrr Mørch, Sven Even Borgos, Wanja Kildal, Sofie Snipstad, Einar Sulheim, Karianne Giller Fleten, Hanne Arenberg Askautrud, Olav Engebraaten, Kjersti Flatmark, Tore Geir Iversen, Kirsten Sandvig, Tore Skotland, Gunhild M. Mælandsmo
To investigate the different efficacies obtained with nanoparticle-encapsulated versus free cabazitaxel, mass spectrometry quantification of cabazitaxel was performed in mice plasma and selected tissue samples. Nanoparticle-encapsulated drug had a longer circulation time in blood. ...
Pressure Sensors: Transparent, Flexible, Conformal Capacitive Pressure Sensors with Nanoparticles (Small 8/2018)
Small (IF 10.856) Pub Date : 2018-02-22 ,DOI:10.1002/smll.201870032
Hyeohn Kim, Gwangmook Kim, Taehoon Kim, Sangwoo Lee, Donyoung Kang, Min-Soo Hwang, Youngcheol Chae, Shinill Kang, Hyungsuk Lee, Hong-Gyu Park, Wooyoung Shim
Nanoparticle-dispersed dielectrics are used to build a highly sensitive pressure sensor, which is further integrated into a pressure monitoring health application and a functional touch interface. ...
Zinc Oxide Nanoparticles and Voltage‐Gated Human Kv11.1 Potassium Channels Interact through a Novel Mechanism
Small (IF 10.856) Pub Date : 2018-02-26 ,DOI:10.1002/smll.201703403
Stefania Piscopo; Euan R. Brown
Membrane–nanoparticle interactions are important in determining the effects of manufactured nanomaterials on cell physiology and pathology. ...
Mechanism-based pharmacokinetic (MBPK) models describe the complex plasma kinetics of three antiretrovirals delivered by a long-acting anti-HIV drug combination nanoparticle formulation
Journal of Controlled Release (IF 7.901) Pub Date : 2018-02-10 ,DOI:10.1016/j.jconrel.2018.02.003
John C. Kraft, Lisa A. McConnachie, Josefin Koehn, Loren Kinman, Jianguo Sun, Ann C. Collier, Carol Collins, Danny D. Shen, Rodney J.Y. Ho
Based upon plasma PK data obtained after single administration of TLC-ART101 (DcNPs) and a solution formulation of free triple-ARVs, the models feature uptake from the SC injection site that respectively routes free and nanoparticle-associated ARVs via the blood vasculature and lymphatics, and their ...
Light‐Triggered Genome Editing: Cre Recombinase Mediated Gene Editing with Near‐Infrared Light
Small (IF 10.856) Pub Date : 02 July 20 ,DOI:10.1002/smll.201800543
Demosthenes P. Morales; Erin N. Morgan; Meghan McAdams; Amanda B. Chron; Jeong Eun Shin; Joseph A. Zasadzinski; Norbert O. Reich
A light‐activated genome editing platform based on the release of enzymes from a plasmonic nanoparticle carrier when exposed to biocompatible near‐infrared light pulses is described. ...
Photosensitizer and Autophagy Promoter Coloaded ROS‐Responsive Dendrimer‐Assembled Carrier for Synergistic Enhancement of Tumor Growth Suppression
Small (IF 10.856) Pub Date : 2018-08-27 ,DOI:10.1002/smll.201802337
Ting Wang; Jinhui Hu; Hao Luo; Huiyang Li; Jiahong Zhou; Lin Zhou; Shaohua Wei
Based on this preliminary result, a ROS‐sensitive self‐assembled dendrimer nanoparticle is exploited as a carrier to codeliver an autophagy promoter (rapamycin, Rapa) and photosensitizer (phthalocyanine, Pc) to the tumor. ...
Recent advances in applying nanotechnologies for cancer immunotherapy
Journal of Controlled Release (IF 7.901) Pub Date : 2018-09-14 ,DOI:10.1016/j.jconrel.2018.09.010
Reza Mahjub, Sukhdeep Jatana, Suen Ern Lee, Zhu Qin, Griffin Pauli, Meysam Soleimani, Soheil Madadi, Shyh-Dar Li
In this article, we focus on recent advances made within the last 5 years in nanoparticle-based cancer immunotherapy, including peptide- and nucleic acid-based nanovaccines, nanomedicines containing an immunoadjuvant to activate antitumor immunity, nanoparticle delivery of immune checkpoint inhibitors ...
Erythrocyte-cancer hybrid membrane-camouflaged melanin nanoparticles for enhancing photothermal therapy efficacy in tumors
Biomaterials (IF 10.273) Pub Date : 2018-11-15 ,DOI:10.1016/j.biomaterials.2018.11.021
Qin Jiang, Yao Liu, Ranran Guo, Xianxian Yao, Seunghyun Sung, Zhiqing Pang, Wuli Yang
Hybrid membrane of different types of cells could be coated onto nanoparticle surface to achieve additional functions. ...
Intranasal Nanovaccine Confers Homo‐ and Hetero‐Subtypic Influenza Protection
Small (IF 10.856) Pub Date : 2018-02-12 ,DOI:10.1002/smll.201703207
Mi Qi; Xian‐En Zhang; Xianxun Sun; Xiaowei Zhang; Yanfeng Yao; Siling Liu; Ze Chen; Wei Li; Zhiping Zhang; Jianjun Chen; Zongqiang Cui
The results suggest that the 3M2e‐rHF nanoparticle is a promising, needle‐free, intranasally administered, cross‐protective influenza vaccine. ...
Fabrication of Nanoreaction Clusters with Dual‐Functionalized Protein Cage Nanobuilding Blocks
Small (IF 10.856) Pub Date : 31 July 20 ,DOI:10.1002/smll.201801488
Hyukjun Choi; Bongseo Choi; Gwang Joong Kim; Han‐ul Kim; Hansol Kim; Hyun Suk Jung; Sebyung Kang
The approaches described here may provide new opportunities for fabricating functional nanostructures and nanoreaction clusters, leading to the development of new protein nanoparticle‐based nanostructured biosensor devices. ...
Immunoengineering through cancer vaccines – A personalized and multi-step vaccine approach towards precise cancer immunity
Journal of Controlled Release (IF 7.901) Pub Date : 2018-09-14 ,DOI:10.1016/j.jconrel.2018.09.009
Lien Lybaert, Karim Vermaelen, Bruno G. De Geest, Lutz Nuhn
Nanoparticle-based delivery platforms can assist in combination treatments e.g. with multiple immune stimulatory signales (PAMPs and DAMPs) to increase the probability of evoking broader and all-embracing cytotoxic and memory T-cell responses. ...
Regulatory T cell-targeted hybrid nanoparticles combined with immuno-checkpoint blockage for cancer immunotherapy
Journal of Controlled Release (IF 7.901) Pub Date : 2018-05-17 ,DOI:10.1016/j.jconrel.2018.05.018
Wenquan Ou, Raj Kumar Thapa, Liyuan Jiang, Soe Zar Chi, Milan Gautam, Jae-Hoon Chang, Jee-Heon Jeong, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh. Kim
In addition, an in vivo study revealed high tumor accumulation of the hybrid nanoparticle. ...
Glycosylated superparamagnetic nanoparticle gradients for osteochondral tissue engineering
Biomaterials (IF 10.273) Pub Date : 2018-05-21 ,DOI:10.1016/j.biomaterials.2018.05.029
Chunching Li, James PK. Armstrong, Isaac J. Pence, Worrapong Kit-Anan, Jennifer L. Puetzer, Sara Correia Carreira, Axel C. Moore, Molly M. Stevens
In developmental biology, gradients of bioactive signals direct the formation of structural transitions in tissue that are key to physiological function. Failure to reproduce these native features in an in vitro setting can severely limit the success of bioengineered tissue constructs. In this report, we introduce a facile and rapid platform that uses magnetic field alignment of glycosylated superparamagnetic iron oxide nanoparticles, pre-loaded with growth factors, to pattern biochemical gradients into a range of biomaterial systems. Gradients of bone morphogenetic protein 2 in agarose hydrogels were used to spatially direct the osteogenesis of human mesenchymal stem cells and generate robust osteochondral tissue constructs exhibiting a clear mineral transition from bone to cartilage. Interestingly, the smooth gradients in growth factor concentration gave rise to biologically-relevant, emergent structural features, including a tidemark transition demarcating mineralized and non-mineralized tissue and an osteochondral interface rich in hypertrophic chondrocytes. This platform technology offers great versatility and provides an exciting new opportunity for overcoming a range of interfacial tissue engineering challenges. ...
A Superior Method for Constructing Electrical Percolation Network of Nanocomposite Fibers: In Situ Thermally Reduced Silver Nanoparticles
Small (IF 10.856) Pub Date : 2018-12-04 ,DOI:10.1002/smll.201803255
C. Muhammed Ajmal; Seonghyun Bae; Seunghyun Baik
However, the nanoparticle mixing approach results in aggregation and dispersion problems. A revolutionary synthesis method by premixing silver precursor ions (silver ammonium acetate) with polyvinyl alcohol is reported here. ...
Antiglioma via regulating oxidative stress and remodeling tumor-associated macrophage using lactoferrin-mediated biomimetic codelivery of simvastatin/fenretinide
Journal of Controlled Release (IF 7.901) Pub Date : 2018-08-08 ,DOI:10.1016/j.jconrel.2018.08.012
Xiaopeng Mo, Zening Zheng, Yang He, Huihai Zhong, Xuejia Kang, Mingjie Shi, Tuanbing Liu, Zheng Jiao, Yongzhuo Huang
., simvastatin and fenretinide) was revealed to be potent for treating glioma, which was co-encapsulated into a TPGS-TAT-embedded lactoferrin nanoparticle system for achieving brain-targeted biomimetic delivery via the LRP-1 receptor. ...
Transparent Electronics: Defect‐Free, Highly Uniform Washable Transparent Electrodes Induced by Selective Light Irradiation (Small 21/2018)
Small (IF 10.856) Pub Date : 2018-05-24 ,DOI:10.1002/smll.201870094
Zhaoyang Zhong; Kyoohee Woo; Inhyuk Kim; Hyuntae Kim; Pyeongsam Ko; Dongwoo Kang; Sin Kwon; Hyunchang Kim; Hongseok Youn; Jooho Moon
In article number 1800676, Kyoohee Woo, Jooho Moon, and co‐workers describe a simple, large area‐compatible, intense light‐induced patterning process to fabricate Ag nanoparticle–carbon nanotube‐based defect‐free, highly conductive, mesh transparent electrodes with exceptional durability after 100 washing ...
Macrophage entrapped silica coated superparamagnetic iron oxide particles for controlled drug release in a 3D cancer model
Journal of Controlled Release (IF 7.901) Pub Date : 2018-12-23 ,DOI:10.1016/j.jconrel.2018.12.040
Sami Ullah, Katja Seidel, Sibel Türkkan, Dawid Peter Warwas, Tatyana Dubich, Manfred Rohde, Hansjörg Hauser, Peter Behrens, Andreas Kirschning, Mario Köster, Dagmar Wirth
It is based on macrophages as transporters for nanoparticle-coupled drugs as well as controlled release of drugs by hyperthermia mediated disruption of the cargo cells and simultaneous deliberation of nanoparticle-linked drugs. ...
Lipid nanoparticles with minimum burst release of TNF-α siRNA show strong activity against rheumatoid arthritis unresponive to methotrexate
Journal of Controlled Release (IF 7.901) Pub Date : 2018-05-31 ,DOI:10.1016/j.jconrel.2018.05.035
Abdulaziz M. Aldayel, Hannah L. O'Mary, Solange A. Valdes, Xu Li, Sachin G. Thakkar, Bahar E. Mustafa, Zhengrong Cui
These findings highlight the potential of using this novel siRNA nanoparticle formulation to effectively treat arthritis, potentially in patients who do not respond adequately to methotrexate. ...
Visualizing Oxidative Cellular Stress Induced by Nanoparticles in the Subcytotoxic Range Using Fluorescence Lifetime Imaging
Small (IF 10.856) Pub Date : 2018-05-04 ,DOI:10.1002/smll.201800310
Jens Balke; Pierre Volz; Falko Neumann; Robert Brodwolf; Alexander Wolf; Hannah Pischon; Moritz Radbruch; Lars Mundhenk; Achim D. Gruber; Nan Ma; Ulrike Alexiev
FLIM‐ROX measures very low ROS levels upon gold nanoparticle exposure, which is undetectable by the conventional method. ...
Stem Cell Imaging: Effective Labeling of Primary Somatic Stem Cells with BaTiO3 Nanocrystals for Second Harmonic Generation Imaging (Small 8/2018)
Small (IF 10.856) Pub Date : 2018-02-22 ,DOI:10.1002/smll.201870036
Nami Sugiyama, Ali Y. Sonay, Roxanne Tussiwand, Bruce E. Cohen, Periklis Pantazis
Quantitative single-cell analysis reveals that freshly isolated HSCs show limited nanoparticle uptake, whereas HSCs entering a proliferative state display a 2.5-fold increase in uptake. ...
Junction opener protein increases nanoparticle accumulation in solid tumors
Journal of Controlled Release (IF 7.901) Pub Date : 2018-01-03 ,DOI:10.1016/j.jconrel.2017.12.032
Christine E. Wang, Roma C. Yumul, Jonathan Lin, Yilong Cheng, André Lieber, Suzie H. Pun
Carcinomas contain tight junctions that can limit the penetration and therefore therapeutic efficacy of anticancer agents, especially those delivered by nano-carrier systems. The junction opener (JO) protein is a virus-derived protein that can transiently open intercellular junctions in epithelial tumors by cleaving the junction protein desmoglein-2 (DSG2). Co-administration of JO was previously shown to significantly increase the efficacy of various monoclonal antibodies and chemotherapy drugs in murine tumor models by allowing for increased intratumoral penetration of the drugs. To investigate the size-dependent effect of JO on nanocarriers, we used PEGylated gold nanoparticles (AuNPs) of two different sizes as model drugs and investigated their biodistribution following JO protein treatment. By inductively coupled plasma mass spectrometry (ICP-MS), JO was found to significantly increase bulk tumor accumulation of AuNPs of 35 nm but not 120 nm particles in both medium (200–300 mm3) and large (500–600 mm3) tumors. Image analysis of tumor sections corroborates this JO-mediated increase in tumor accumulation of AuNPs. Quantitative intratumoral distribution analyses show that most nanoparticles were found within 100 μm of the vasculature, and that the penetration profiles of AuNPs are not significantly affected by JO treatment at the 6 h timepoint. ...
Investigation of charge ratio variation in mRNA – DEAE-dextran polyplex delivery systems
Biomaterials (IF 10.273) Pub Date : 2018-11-17 ,DOI:10.1016/j.biomaterials.2018.10.020
C. Siewert, H. Haas, T. Nawroth, A. Ziller, S.S. Nogueira, M.A. Schroer, C.E. Blanchet, D.I. Svergun, A. Radulescu, F. Bates, Y. Huesemann, M.P. Radsak, U. Sahin, P. Langguth
Information on the molecular organization of the mRNA nanoparticle products may provide a valuable basis for defining critical quality attributes of drug products for pharmaceutical application. ...
Exploiting the bioengineering versatility of lactobionic acid in targeted nanosystems and biomaterials
Journal of Controlled Release (IF 7.901) Pub Date : 2018-08-25 ,DOI:10.1016/j.jconrel.2018.08.030
Saúl Alonso
Lactobionic acid (LBA) has rapidly emerged as a strategic functionalization molecule in the development of nanoparticle-based platforms and biomaterials with promising therapeutic applications. ...
Polymer Nanocomposites Characterization: Atomic Layer Deposition of Metal Oxide on Nanocellulose for Enabling Microscopic Characterization of Polymer Nanocomposites (Small 46/2018)
Small (IF 10.856) Pub Date : 2018-11-15 ,DOI:10.1002/smll.201870217
Athanasia A. Septevani; David A. C. Evans; Alireza Hosseinmardi; Darren J. Martin; John Simonsen; John F. Conley; Pratheep K. Annamalai
Characterization of organic nanoparticle orientation in a polyurethane foam, which exhibits anisotropic mechanical properties, remains challenging. In article number 1803439, John F. Conley Jr., Pratheep K. ...
Multifunctional hybrid nanoconstruct of zerovalent iron and carbon dots for magnetic resonance angiography and optical imaging: An In vivo study.
Biomaterials (IF 10.273) Pub Date : 2018-04-24 ,DOI:10.1016/j.biomaterials.2018.04.012
N Nimi,Ariya Saraswathy,Shaiju S Nazeer,Nimmi Francis,Sachin J Shenoy,Ramapurath S Jayasree
For multimodal imaging of the liver, initially the ZVI nanoparticle was tailored with a highly liver specific polysaccharide pullulan, and later with fluorescent carbon dots (Cdts) facilitating both optical and MR imaging. ...
Carrier-free nanoparticles of cathepsin B-cleavable peptide-conjugated doxorubicin prodrug for cancer targeting therapy
Journal of Controlled Release (IF 7.901) Pub Date : 2018-12-11 ,DOI:10.1016/j.jconrel.2018.11.032
Man Kyu Shim, Jooho Park, Hong Yeol Yoon, Sangmin Lee, Wooram Um, Jong-Ho Kim, Sun-Woong Kang, Joung-Wook Seo, Soo-Wang Hyun, Jae Hyung Park, Youngro Byun, Ick Chan Kwon, Kwangmeyung Kim
Cancer nanomedicine using nanoparticle-based delivery systems has shown outstanding promise in recent decades for improving anticancer treatment. ...
Delivery of small interfering RNA against Nogo-B receptor via tumor-acidity responsive nanoparticles for tumor vessel normalization and metastasis suppression
Biomaterials (IF 10.273) Pub Date : 2018-05-21 ,DOI:10.1016/j.biomaterials.2018.05.034
Bin Wang, Yanping Ding, Xiaozheng Zhao, Xuexiang Han, Na Yang, Yinlong Zhang, Ying Zhao, Xiao Zhao, Mohammad Taleb, Qing Robert Miao, Guangjun Nie
Here a surface charge switchable polymeric nanoparticle that was sensitive to the slightly acidic tumor microenvironment was developed for steady delivery of NgBR siRNA to tumor tissues. ...
Effective Labeling of Primary Somatic Stem Cells with BaTiO3 Nanocrystals for Second Harmonic Generation Imaging
Small (IF 10.856) Pub Date : 2018-01-22 ,DOI:10.1002/smll.201703386
Nami Sugiyama, Ali Y. Sonay, Roxanne Tussiwand, Bruce E. Cohen, Periklis Pantazis
Understanding the nanoparticle stem cell interaction allows to establish an effective and safe nanoparticle labeling strategy into somatic stem cells that can critically contribute to an understanding of their in vivo therapeutic potential. ...
Scalable 3D Nanoparticle Trap for Electron Microscopy Analysis
Small (IF 10.856) Pub Date : 2018-10-15 ,DOI:10.1002/smll.201803283
Xingwu Sun; Erwin J. W. Berenschot; Henk‐Willem Veltkamp; Han J. G. E. Gardeniers; Niels R. Tas
Arrays of nanoscale pyramidal cages embedded in a silicon nitride membrane are fabricated with an order of magnitude miniaturization in the size of the cages compared to previous work. This becomes possible by combining the previously published wafer‐scale corner lithography process with displacement Talbot lithography, including an additional resist etching step that allows the creation of masking dots with a size down to 50 nm, using a conventional 365 nm UV source. The resulting pyramidal cages have different entrance and exit openings, which allows trapping of nanoparticles within a predefined size range. The cages are arranged in a well‐defined array, which guarantees traceability of individual particles during post‐trapping analysis. Gold nanoparticles with a size of 25, 150, and 200 nm are used to demonstrate the trapping capability of the fabricated devices. The traceability of individual particles is demonstrated by transferring the transmission electron microscopy (TEM) transparent devices between scanning electron microscopy and TEM instruments and relocating a desired collection of particles. ...
Redox‐Responsive Nanoparticle‐Mediated Systemic RNAi for Effective Cancer Therapy
Small (IF 10.856) Pub Date : 2018-09-17 ,DOI:10.1002/smll.201802565
Xiaoding Xu; Jun Wu; Shuaishuai Liu; Phei Er Saw; Wei Tao; Yujing Li; Lisa Krygsman; Srinivasan Yegnasubramanian; Angelo M. De Marzo; Jinjun Shi; Charles J. Bieberich; Omid C. Farokhzad
Biodegradable polymeric nanoparticles (NPs) have demonstrated significant potential to improve the systemic delivery of RNA interference (RNAi) therapeutics, such as small interfering RNA (siRNA), for cancer therapy. However, the slow and inefficient siRNA release inside tumor cells generally observed for most biodegradable polymeric NPs may result in compromised gene silencing efficacy. Herein, a biodegradable and redox‐responsive NP platform, composed of a solid poly(disulfide amide) (PDSA)/cationic lipid core and a lipid–poly(ethylene glycol) (lipid–PEG) shell for systemic siRNA delivery to tumor cells, is developed. This newly generated NP platform can efficiently encapsulate siRNA under extracellular environments and can respond to the highly concentrated glutathione (GSH) in the cytoplasm to induce fast intracellular siRNA release. By screening a library of PDSA polymers with different structures and chain lengths, the optimized NP platform shows the unique features of i) long blood circulation, ii) high tumor accumulation, iii) fast GSH‐triggered intracellular siRNA release, and iv) exceptionally effective gene silencing. Together with the facile polymer synthesis technique and robust NP formulation enabling scale‐up, this new redox‐responsive NP platform may become an effective tool for RNAi‐based cancer therapy. ...
Exploiting topology-directed nanoparticle disassembly for triggered drug delivery
Biomaterials (IF 10.273) Pub Date : 2018-07-17 ,DOI:10.1016/j.biomaterials.2018.07.019
Maria C. Arno, Rebecca J. Williams, Panagiotis Bexis, Anaїs Pitto-Barry, Nigel Kirby, Andrew P. Dove, Rachel K. O'Reilly
The physical properties of cyclic and linear polymers are markedly different; however, there are few examples which exploit these differences in clinical applications. In this study, we demonstrate that self-assemblies comprised of cyclic-linear graft copolymers are significantly more stable than the equivalent linear-linear graft copolymer assemblies. This difference in stability can be exploited to allow for triggered disassembly by cleavage of just a single bond within the cyclic polymer backbone, via disulfide reduction, in the presence of intracellular levels of l-glutathione. This topological effect was exploited to demonstrate the first example of topology-controlled particle disassembly for the controlled release of an anti-cancer drug in vitro. This approach represents a markedly different strategy for controlled release from polymer nanoparticles and highlights for the first time that a change in polymer topology can be used as a trigger in the design of delivery vehicles. We propose such constructs, which demonstrate disassembly behavior upon a change in polymer topology, could find application in the targeted delivery of therapeutic agents. ...
Gold nanoparticle should understand protein corona for being a clinical nanomaterial
Journal of Controlled Release (IF 7.901) Pub Date : 2018-01-04 ,DOI:10.1016/j.jconrel.2018.01.002
Fahimeh Charbgoo, Mojgan Nejabat, Khalil Abnous, Fatemeh Soltani, Seyed Mohammad Taghdisi, Mona Alibolandi, W. Thomas Shier, Terry W.J. Steele, Mohammad Ramezani
Gold nanoparticles (AuNPs) have attracted great attention in biomedical fields due to their unique properties. However, there are few reports on clinical trial of these nanoparticles. In vivo, AuNPs face complex biological fluids containing abundant proteins, which challenge the prediction of their fate that is known as “bio-identity”. These proteins attach onto the AuNPs surface forming protein corona that makes the first step of nano-bio interface and dictates the subsequent AuNPs fate. Protein corona formation even stealth active targeting effect of AuNPs. Manipulating the protein corona identity based on the researcher goal is the way to employ corona to achieve maximum effect in therapy or other applications. In this review, we provide details on the biological identity of AuNPs under various environmental- and/or physiological conditions. We also highlight how the particular corona can direct the biodistribution of AuNPs. We further discuss the strategies available for controlling or reducing corona formation on AuNPs surface and achieving desired effects using AuNPs in vivo by engineering protein corona on their surface. ...
Platelet membrane coating coupled with solar irradiation endows a photodynamic nanosystem with both improved antitumor efficacy and undetectable skin damage
Biomaterials (IF 10.273) Pub Date : 2018-01-02 ,DOI:10.1016/j.biomaterials.2017.12.028
Lulu Xu, Feng Gao, Feng Fan, Lihua Yang
We herein show that platelet membrane-coating over a photodynamic nanoparticle coupled with solar irradiation may simultaneously resolve all challenges above. ...
Optimization of lipid-assisted nanoparticle for disturbing neutrophils-related inflammation
Biomaterials (IF 10.273) Pub Date : 2018-04-26 ,DOI:
Yang Liu, Zhi-Ting Cao, Cong-Fei Xu, Zi-Dong Lu, Ying-Li Luo, Jun Wang
Inflammation is closely related to the development of many diseases and is commonly characterized by abnormal infiltration of immune cells, especially neutrophils. The current therapeutics of inflammatory diseases give little attention to direct modulation of these diseases with respect to immune cells. Nanoparticles are applied for efficient drug delivery into the disease-related immune cells, but their performance is significantly affected by their surface properties. In this study, to optimize the properties of nanoparticles for modulating neutrophils-related inflammation, we prepared a library of poly(ethylene glycol)-b-poly(lactide-co-glycolide) (PEG-b-PLGA)-based cationic lipid-assisted nanoparticles (CLANs) with different surface PEG density and surface charge. Optimized CLANs for neutrophils targeting were screened in high-fat diet (HFD)-induced type 2 diabetes (T2D) mice. Then, a CRISPR-Cas9 plasmid expressing a guide RNA (gRNA) targeting neutrophil elastase (NE) was encapsulated into the optimized CLAN and denoted as CLANpCas9/gNE. After intravenous injection, CLANpCas9/gNE successfully disrupted the NE gene of neutrophils and mitigated the insulin resistance of T2D mice via reducing the inflammation in epididymal white adipose tissue (eWAT) and in the liver. This strategy provides an example of abating the inflammatory microenvironment by directly modulating immune cells with nanoparticles carrying genome editing tools. ...
Key Role of TFEB Nucleus Translocation for Silver Nanoparticle‐Induced Cytoprotective Autophagy
Small (IF 10.856) Pub Date : 2018-02-19 ,DOI:10.1002/smll.201703711
Jun Lin; Yiming Liu; Hao Wu; Zhihai Huang; Jingfan Ma; Chang Guo; Feng Gao; Peipei Jin; Pengfei Wei; Yunjiao Zhang; Liu Liu; Rui Zhang; Longxin Qiu; Ning Gu; Longping Wen
Transcription factor EB (TFEB) is a master regulator of autophagy and lysosomal biogenesis. Here, silver nanoparticles (Ag NPs)‐induced cytoprotective autophagy required TFEB is shown. Ag NPs‐induced nucleus translocation of TFEB through a well‐established mechanism involving dephosphorylation of TFEB at serine‐142 and serine‐211 but independent of both the mTORC1 and ERK1/2 pathways. TFEB nucleus translocation precedes autophagy induced by Ag NPs and leads to enhanced expression of autophagy‐essential genes. Knocking down the expression of TFEB attenuates the autophagy induction is demonstrated, and in the meantime, enhanced cell killing in HeLa cells treats with Ag NPs, indicating that TFEB is the key mediator for Ag NPs‐induced cytoprotective autophagy. The results pinpoint TFEB as a potential target for developing more effective Ag NPs‐based cancer therapeutics. ...
Nano-targeted relaxin impairs fibrosis and tumor growth in pancreatic cancer and improves the efficacy of gemcitabine in vivo
Journal of Controlled Release (IF 7.901) Pub Date : 2018-10-02 ,DOI:10.1016/j.jconrel.2018.09.031
Deby F. Mardhian, Gert Storm, Ruchi Bansal, Jai Prakash
Thus, we designed and successfully synthesized a nanoparticle system by chemically conjugating RLX to superparamagnetic iron oxide nanoparticle (SPION) to improve its pharmacokinetics. Interestingly, we found RLX-SPION to be more efficacious compared to free RLX in vitro. ...
A bird's eye view of nanoparticles prepared by electrospraying: advancements in drug delivery field
Journal of Controlled Release (IF 7.901) Pub Date : 2018-07-24 ,DOI:10.1016/j.jconrel.2018.07.036
Abhijit Pawar, Shreya Thakkar, Manju Misra
Basic principle, instrumental set-up, advantages and limitations of electrospraying technique over other conventional nanoparticle production techniques and critical process parameters affecting nanoparticleproperties is dealt in detail. ...
Lanthanide-doped nanoparticles conjugated with an anti-CD33 antibody and a p53-activating peptide for acute myeloid leukemia therapy
Biomaterials (IF 10.273) Pub Date : 2018-03-14 ,DOI:10.1016/j.biomaterials.2018.03.025
Fan Niu, Jin Yan, Bohan Ma, Shichao Li, Yongping Shao, Pengcheng He, Wanggang Zhang, Wangxiao He, Peter X. Ma, Wuyuan Lu
The resultant nanoparticle antiCD33-LONp-PMI, while nontoxic to normal cells, induced apoptosis of AML cell lines and primary leukemic cells isolated from AML patients by antagonizing MDM2 and/or MDMX to activate the p53 pathway. ...
Nanocapsule-mediated cytosolic siRNA delivery for anti-inflammatory treatment
Journal of Controlled Release (IF 7.901) Pub Date : 2018-06-05 ,DOI:10.1016/j.jconrel.2018.06.001
Ying Jiang, Joseph Hardie, Yuanchang Liu, Moumita Ray, Xiang Luo, Riddha Das, Ryan F. Landis, Michelle Farkas, Vincent M. Rotello
The use of nanoparticle-stabilized nanocapsules for cytosolic siRNA delivery for immunomodulation in vitro and in vivo is reported. These NPSCs deliver siRNA directly to the cytosol of macrophages in vitro with concomitant knockdown of gene expression. ...
In vivo β-catenin attenuation by the integrin α5-targeting nano-delivery strategy suppresses triple negative breast cancer stemness and metastasis
Biomaterials (IF 10.273) Pub Date : 2018-10-18 ,DOI:10.1016/j.biomaterials.2018.10.019
Yunfei Li, Yajuan Xiao, Hsuan-Pei Lin, Derek Reichel, Younsoo Bae, Eun Y. Lee, Yiguo Jiang, Xuefei Huang, Chengfeng Yang, Zhishan Wang
We modified lipid-polymer hybrid (LPH) nanoparticle for TNBC-targeted delivery of diacidic norcantharidin (NCTD), a potent anti-cancer compound but with short half-life. ...
Optimization of lipid-assisted nanoparticle for disturbing neutrophils-related inflammation.
Biomaterials (IF 10.273) Pub Date : 2018-05-04 ,DOI:10.1016/j.biomaterials.2018.04.052
Yang Liu,Zhi-Ting Cao,Cong-Fei Xu,Zi-Dong Lu,Ying-Li Luo,Jun Wang
Inflammation is closely related to the development of many diseases and is commonly characterized by abnormal infiltration of immune cells, especially neutrophils. The current therapeutics of inflammatory diseases give little attention to direct modulation of these diseases with respect to immune cells. Nanoparticles are applied for efficient drug delivery into the disease-related immune cells, but their performance is significantly affected by their surface properties. In this study, to optimize the properties of nanoparticles for modulating neutrophils-related inflammation, we prepared a library of poly(ethylene glycol)-b-poly(lactide-co-glycolide) (PEG-b-PLGA)-based cationic lipid-assisted nanoparticles (CLANs) with different surface PEG density and surface charge. Optimized CLANs for neutrophils targeting were screened in high-fat diet (HFD)-induced type 2 diabetes (T2D) mice. Then, a CRISPR-Cas9 plasmid expressing a guide RNA (gRNA) targeting neutrophil elastase (NE) was encapsulated into the optimized CLAN and denoted as CLANpCas9/gNE. After intravenous injection, CLANpCas9/gNE successfully disrupted the NE gene of neutrophils and mitigated the insulin resistance of T2D mice via reducing the inflammation in epididymal white adipose tissue (eWAT) and in the liver. This strategy provides an example of abating the inflammatory microenvironment by directly modulating immune cells with nanoparticles carrying genome editing tools. ...
Dexamethasone prodrugs as potent suppressors of the Immunostimulatory effects of lipid nanoparticle formulations of nucleic acids
Journal of Controlled Release (IF 7.901) Pub Date : 2018-07-17 ,DOI:10.1016/j.jconrel.2018.07.026
Sam Chen, Josh Zaifman, Jayesh A. Kulkarni, Igor V. Zhigaltsev, Ying K. Tam, Marco A. Ciufolini, Yuen Yi C. Tam, Pieter R. Cullis
Lipid nanoparticles (LNPs) are playing a leading role in enabling clinical applications of gene therapies based on DNA or RNA polymers. One factor impeding clinical acceptance of LNP therapeutics is that LNP formulations of nucleic acid polymers can be immunostimulatory, necessitating co-administration of potent corticosteroid immunosuppressive agents. Here, we describe the development of hydrophobic prodrugs of a potent corticosteroid, dexamethasone, that can be readily incorporated into LNP systems. We show that the presence of the dexamethasone prodrug LD003 effectively suppresses production of cytokines such as KC-GRO, TNFα, IL-1β and IL-6 following intravenous administration of LNP loaded with immune stimulatory oligodeoxynucleotides containing cytosine-guanine dinucleotide motifs. Remarkably, LD003 dose levels corresponding to 0.5 mg/kg dexamethasone achieve a greater immunosuppressive effect than doses of 20 mg/kg of free dexamethasone. Similar immunosuppressive effects are observed for subcutaneously administered LNP-siRNA. Further, the incorporation of low levels of LD003 in LNP containing unmodified mRNA or plasmid DNA significantly reduced pro-inflammatory cytokine levels following intravenous administration. Our results suggest that incorporation of hydrophobic prodrugs such as LD003 into LNP systems could provide a convenient method for avoiding the immunostimulatory consequences of systemic administration of genetic drug formulations. ...
Dual‐Modal NIR‐Fluorophore Conjugated Magnetic Nanoparticle for Imaging Amyloid‐β Species In Vivo
Small (IF 10.856) Pub Date : 07 June 20 ,DOI:10.1002/smll.201800901
Yinhui Li; Di Xu; Hei‐Nga Chan; Chung‐Yan Poon; See‐Lok Ho; Hung‐Wing Li; Man Shing Wong
Senile plaques, the extracellular deposit of amyloid‐β (Aβ) peptides, are one of the neuropathological hallmarks found in Alzheimer's disease (AD) brain. The current method of brain imaging of amyloid plaques based on positron emission tomography (PET) is expensive and invasive with low spatial resolution. Thus, the development of sensitive and nonradiative amyloid‐β (Aβ)‐specific contrast agents is highly important and beneficial to achieve early AD detection, monitor the disease progression, and evaluate the effectiveness of potential AD drugs. Here a neuroprotective dual‐modal nanoprobe developed by integrating highly Aβ‐specific and turn‐on fluorescence cyanine sensors with superparamagnetic iron oxide nanoparticles as an effective near‐infrared imaging (NIRI)/magnetic resonance imaging (MRI) contrast agent for imaging of Aβ species in vivo is reported. This Aβ‐specific probe is found not only nontoxic and noninvasive, but also highly blood brain barrier permeable. It also shows a potent neuroprotective effect against Aβ‐induced toxicities. This nanoprobe is successfully applied for in vivo fluorescence imaging with high sensitivity and selectivity to Aβ species, and MRI with high spatial resolution in an APP/PS1 transgenic mice model. Its potential as a powerful in vivo dual‐modal imaging tool for early detection and diagnosis of AD in humans is affirmed. ...
A novel nanoparticle delivery system for targeted therapy of noise-induced hearing loss
Journal of Controlled Release (IF 7.901) Pub Date : 2018-04-16 ,DOI:
Mohammad N. Kayyali, Julian R.A. Wooltorton, Andrew J. Ramsey, Mei Lin, Tiffany N. Chao, Andrew Tsourkas, Bert W. O'Malley Jr, Daqing Li
Hearing loss is the most prevalent sensory disability worldwide and may be caused by age, drugs or exposure to excessive noise. We have previously developed a minimally-invasive nanohydrogel drug delivery system that successfully delivers nanoparticles into the inner ear. We have substantially extended this technique by functionalizing the nanoparticles and introducing a targeting peptide which recognizes prestin, a transmembrane electromotile protein uniquely expressed in outer hair cells (OHCs) of the inner ear. We demonstrate the successful delivery of molecules and plasmids specifically to OHCs. When compared to untargeted nanoparticles, the delivery of a c-Jun N-terminal kinase (JNK) inhibitor, D-JNKi-1, to OHCs by targeted nanoparticles improved protection from noise induced hearing loss (NIHL). This is the first demonstration of a protection from NIHL using a novel safe and controllable delivery system which is minimally-invasive to the inner ear and, as such, is an extremely appealing technique for use in many clinical applications. ...
Electrocatalytic N-Doped Graphitic Nanofiber – Metal/Metal Oxide Nanoparticle Composites
Small (IF 10.856) Pub Date : 2018-01-22 ,DOI:10.1002/smll.201703459
Hongjie Tang, Wei Chen, Jiangyan Wang, Thomas Dugger, Luz Cruz, David Kisailus
Abstract Carbon-based nanocomposites have shown promising results in replacing commercial Pt/C as high-performance, low cost, nonprecious metal-based oxygen reduction reaction (ORR) catalysts. Developing unique nanostructures of active components (e.g., metal oxides) and carbon materials is essential for their application in next generation electrode materials for fuel cells and metal–air batteries. Herein, a general approach for the production of 1D porous nitrogen-doped graphitic carbon fibers embedded with active ORR components, (M/MOx, i.e., metal or metal oxide nanoparticles) using a facile two-step electrospinning and annealing process is reported. Metal nanoparticles/nanoclusters nucleate within the polymer nanofibers and subsequently catalyze graphitization of the surrounding polymer matrix and following oxidation, create an interconnected graphite–metal oxide framework with large pore channels, considerable active sites, and high specific surface area. The metal/metal oxide@N-doped graphitic carbon fibers, especially Co3O4, exhibit comparable ORR catalytic activity but superior stability and methanol tolerance versus Pt in alkaline solutions, which can be ascribed to the synergistic chemical coupling effects between Co3O4 and robust 1D porous structures composed of interconnected N-doped graphitic nanocarbon rings. This finding provides a novel insight into the design of functional electrocatalysts using electrospun carbon nanomaterials for their application in energy storage and conversion fields. A general approach is reported to produce 1D porous nitrogen-doped graphitic carbon fibers (N-GCFs) with embedded metal/metal oxides. Metal nanoparticles nucleate within the electrospun polymer fibers and subsequently catalyze their graphitization. Benefited from the synergistic effects from electrocatalytic-active Co3O4 and robust nanocarbon structures, the Co3O4@N-GCFs exhibit comparable ORR catalytic activity but superior stability and methanol tolerance versus Pt/C. ...
PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake
Journal of Controlled Release (IF 7.901) Pub Date : 2018-10-15 ,DOI:10.1016/j.jconrel.2018.10.015
Hamideh Parhiz, Vladimir V. Shuvaev, Norbert Pardi, Makan Khoshnejad, Raisa Yu Kiseleva, Jacob S. Brenner, Thomas Uhler, Steven Tuyishime, Barbara L. Mui, Ying K. Tam, Thomas D. Madden, Michael J. Hope, Drew Weissman, Vladimir R. Muzykantov
Systemic administration of lipid nanoparticle (LNP)-encapsulated messenger RNA (mRNA) leads predominantly to hepatic uptake and expression. Here, we conjugated nucleoside-modified mRNA-LNPs with antibodies (Abs) specific to vascular cell adhesion molecule, PECAM-1. ...
Detecting the functional complexities between high-density lipoprotein mimetics.
Biomaterials (IF 10.273) Pub Date : 2018-04-14 ,DOI:10.1016/j.biomaterials.2018.04.011
Yoshitaka J Sei,Jungho Ahn,Taeyoung Kim,Eunjung Shin,Angel J Santiago-Lopez,Seung Soon Jang,Noo Li Jeon,Young C Jang,YongTae Kim
ApoA1-mimetic peptides were formulated as cost-effective alternatives to apoA1-based therapies; reverse-4F (r4F) is one such peptide used as part of a nanoparticle platform. ...
Detecting the functional complexities between high-density lipoprotein mimetics
Biomaterials (IF 10.273) Pub Date : 2018-04-06 ,DOI:
Yoshitaka J. Sei, Jungho Ahn, Taeyoung Kim, Eunjung Shin, Angel J. Santiago-Lopez, Seung Soon Jang, Noo Li Jeon, Young C. Jang, YongTae Kim
ApoA1-mimetic peptides were formulated as cost-effective alternatives to apoA1-based therapies; reverse-4F (r4F) is one such peptide used as part of a nanoparticle platform. ...
Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors.
Biomaterials (IF 10.273) Pub Date : 2018-06-20 ,DOI:10.1016/j.biomaterials.2018.06.015
Jingjing Gan,Yunyan Dou,Yurong Li,Zhenzhen Wang,Lintao Wang,Shang Liu,Qiu Li,Heran Yu,Chunyan Liu,Congwei Han,Zhen Huang,Junfeng Zhang,Chunming Wang,Lei Dong
Macrophages are highly plastic cells that can either mediate or suppress inflammation, depending on their cellular phenotype and cytokine secretion. Inducing macrophages from an inflammatory ('M1') to anti-inflammatory ('M2') phenotype has significant implications for the treatment of inflammatory diseases and regeneration of injured tissues. Although certain cytokines, such as interleukin-4 and -13, are known to induce this phenotypic switch, their therapeutic use in vivo has both safety and efficacy concerns. Here, we demonstrate an alternative approach to change macrophage phenotype from M1 to M2, through inducing the clustering of mannose receptors (MR) on the cell surface, by using carbohydrate-presenting substrates. We prepared and screened glucomannan-decorated silicon oxide of different sizes ranging from 10 to 1000 nm, and identified one type (KSiNP30) that could potently induce MR clustering on macrophages and thereby stimulated the cells into an M2 phenotype - as an unexpected consequence of MR activation. Further administration of KSiNP30 in a murine model of inflammatory bowel disease efficiently alleviated the colitis symptoms, indicating the translational potential of our finding for therapeutic applications. In summary, we report for the first time an approach to modulate cellular immune responses by manipulating the assembly of cell-surface receptors, without the aid of cytokines. Our approach may provide insights for the development of new anti-inflammatory therapies. ...
Efficient in vivo direct conversion of fibroblasts into cardiomyocytes using a nanoparticle-based gene carrier
Biomaterials (IF 10.273) Pub Date : 2018-11-29 ,DOI:10.1016/j.biomaterials.2018.11.034
Yujung Chang, Euiyeon Lee, Junyeop Kim, Yoo-Wook Kwon, Youngeun Kwon, Jongpil Kim
The reprogramming of induced cardiomyocytes (iCMs) has shown potential in regenerative medicine. However, in vivo reprogramming of iCMs is significantly inefficient, and novel gene delivery systems are required to more efficiently and safely induce in vivo reprogramming of iCMs for therapeutic applications in heart injury. In this study, we show that cationic gold nanoparticles (AuNPs) loaded with Gata4, Mef2c, and Tbx5 function as nanocarriers for cardiac reprogramming. The AuNP/GMT/PEI nanocomplexes show high reprogramming efficiency in human and mouse somatic cells with low cytotoxicity and direct conversion into iCMs without integrating factors into the genome. Importantly, AuNP/GMT/PEI nanocomplexes led to efficient in vivo conversion into cardiomyocytes after myocardial infarction (MI), resulting in the effective recovery of cardiac function and scar area. Taken together, these results show that the AuNP/GMT/PEI nanocarrier can be used to develop effective therapeutics for heart regeneration in cardiac disease patients. ...
Degradable poly(ethylene glycol) (PEG)-based hydrogels for spatiotemporal control of siRNA/nanoparticle delivery
Journal of Controlled Release (IF 7.901) Pub Date : 2018-08-03 ,DOI:10.1016/j.jconrel.2018.08.002
Yuchen Wang, Sue Zhang, Danielle S.W. Benoit
Despite great therapeutic potential and development of a repertoire of delivery approaches addressing degradation and cellular uptake limitations, small interfering RNA (siRNA) exhibits poorly controlled tissue-specific localization. To overcome this hurdle, siRNA was complexed to nanoparticles (siRNA/NP) embedded within poly(ethylene glycol)-poly(lactic acid)-dimethacrylate (PEG-PLA-DM) hydrogels with the hypothesis that hydrolytic degradation of ester bonds within the PLA crosslinks would provide tunable, sustained siRNA/NP release. Hydrogels formed from macromers with increasing PLA repeats (e.g., 0 or non-degradable to 5 PLA repeats flanking PEG cores) and mixtures of nondegradable PEG-DM (0 PLA) and degradable PEG-PLA5-DM macromers were investigated. Hydrogels formed only with fully degradable crosslinks degraded rapidly over 6–14 days with limited control over siRNA/NP release. However, hydrogels formed with mixtures of nondegradable and 20%, 50%, and 100% degradable macromers resulted in siRNA/NP release over 3 to 28 days. Subsequently, gene silencing mediated by released siRNA/NP from 20% and 50% degradable hydrogels was sustained for ~28 days. Furthermore, in vivo imaging showed that hydrogel degradation controlled siRNA/NP localization, with sustained siRNA/NP release from 0%, 20% and 50% degradable hydrogels over 28, 21, and 15 days. A model, which accounts for hydrogel degradation rate and siRNA/NP diffusion, was developed to enable rational design of siRNA/NP delivery depots. Overall, this study shows that siRNA/NP release can be sustained via encapsulation in hydrogel depots with tunable degradation kinetics and modeled for a priori design of delivery depots. ...
Engineered nanoparticles disguised as macrophages for trapping lipopolysaccharide and preventing endotoxemia
Biomaterials (IF 10.273) Pub Date : 2018-10-24 ,DOI:10.1016/j.biomaterials.2018.10.029
Song Shen, Fei Han, Anran Yuan, Lin Wu, Jin Cao, Jing Qian, Xueyong Qi, Yongsheng Yan, Yanru Ge
Considering the crucial role of immune cells in LPS recognition and inflammation mediation, we design a disguised nanoparticle using macrophage membranes as bait to specifically capture and deactivate LPS. ...
Perspective – Effect of obesity on biodistribution of nanoparticles
Journal of Controlled Release (IF 7.901) Pub Date : 2018-05-10 ,DOI:10.1016/j.jconrel.2018.05.003
Claudiana de Jesus Felismino, Edward Helal-Neto, Filipe Leal Portilho, Suyene Rocha Pinto, Félix Sancenón, Ramón Martínez-Máñez, Agatha de Assis Ferreira, Simone Vargas da Silva, Thereza Christina Barja-Fidalgo, Ralph Santos-Oliveira
Here, we evaluated two nanoparticles: magnetic core mesoporous silica (MSN) (58 nm) and polycaprolactone (PCL) nanoparticle (280 nm) in obese mice. Changes in the biodistribution were observed, especially considering the mononuclear phagocyte system (MPS), and the visceral fat tissue. ...
Recyclable magnetic nanoparticles grafted with antimicrobial metallopolymer-antibiotic bioconjugates.
Biomaterials (IF 10.273) Pub Date : 2018-05-16 ,DOI:10.1016/j.biomaterials.2018.05.007
Parasmani Pageni,Peng Yang,Marpe Bam,Tianyu Zhu,Yung Pin Chen,Alan W Decho,Mitzi Nagarkatti,Chuanbing Tang
The enhanced antibacterial activity was a result of synergy of antimicrobial segments that facilitate the inhibition of hydrolysis of antibiotics and local enhancement of antibiotic concentration on a nanoparticlesurface. ...
Spontaneous Reshaping and Splitting of AgCl Nanocrystals under Electron Beam Illumination
Small (IF 10.856) Pub Date : 2018-10-07 ,DOI:10.1002/smll.201803231
Xuezeng Tian; Utkarsh Anand; Utkur Mirsaidov; Haimei Zheng
However, the dynamics of individual AgCl nanoparticle motion in liquids upon illumination remains elusive. Here, using liquid cell transmission electron microscope (TEM), AgCl nanocrystals reshaping and splitting spontaneously in an aqueous solution under electron beam illumination are observed. ...
Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs
Journal of Controlled Release (IF 7.901) Pub Date : 2018-01-31 ,DOI:10.1016/j.jconrel.2018.01.031
Laura Sánchez-García, Naroa Serna, Patricia Álamo, Rita Sala, María Virtudes Céspedes, Mònica Roldan, Alejandro Sánchez-Chardi, Ugutz Unzueta, Isolda Casanova, Ramón Mangues, Esther Vázquez, Antonio Villaverde
Loading capacity and drug leakage from vehicles during circulation in blood is a major concern when developing nanoparticle-based cell-targeted cytotoxics. ...
A novel scavenging tool for cancer biomarker discovery based on the blood-circulating nanoparticle protein corona
Biomaterials (IF 10.273) Pub Date : 2018-10-13 ,DOI:10.1016/j.biomaterials.2018.10.011
Marilena Hadjidemetriou, Zahraa Al-ahmady, Maurizio Buggio, Joe Swift, Kostas Kostarelos
The prominent discrepancy between the significant investment towards plasma biomarker discovery and the very low number of biomarkers currently in clinical use stresses the need for discovery technologies. The discovery of protein biomarkers present in human blood by proteomics is tremendously challenging, owing to the large dynamic concentration range of blood proteins. Here, we describe the use of blood-circulating lipid-based nanoparticles (NPs) as a scavenging tool to comprehensively analyse the blood proteome. We aimed to exploit the spontaneous interaction of NPs with plasma proteins once injected in the bloodstream, known as ‘protein corona’, in order to facilitate the capture of tumor-specific molecules. We employed two different tumor models, a subcutaneous melanoma model (B16-F10) and human lung carcinoma xenograft model (A549) and comprehensively compared by mass spectrometry the in vivo protein coronas formed onto clinically used liposomes, intravenously administered in healthy and tumor-bearing mice. The results obtained demonstrated that blood-circulating liposomes surface-capture and amplify a wide range of different proteins including low molecular weight (MW) and low abundant tumor specific proteins (intracellular products of tissue leakage) that could not be detected by plasma analysis, performed in comparison. Most strikingly, the NP (liposomal) corona formed in the xenograft model was found to consist of murine host response proteins, as well as human proteins released from the inoculated and growing human cancer cells. This study offers direct evidence that the in vivo NP protein corona could be deemed as a valuable tool to enrich the blood proteomic analysis and to allow the discovery of potential biomarkers in experimental disease models. ...
Highly Efficient and Stable Flexible Perovskite Solar Cells with Metal Oxides Nanoparticle Charge Extraction Layers
Small (IF 10.856) Pub Date : 2018-02-09 ,DOI:10.1002/smll.201702775
Mehrdad Najafi; Francesco Di Giacomo; Dong Zhang; Santhosh Shanmugam; Alessia Senes; Wiljan Verhees; Afshin Hadipour; Yulia Galagan; Tom Aernouts; Sjoerd Veenstra; Ronn Andriessen
In this study, the fabrication of highly efficient and durable flexible inverted perovskite solar cells (PSCs) is reported. Presynthesized, solution‐derived NiOx and ZnO nanoparticles films are employed at room temperature as a hole transport layer (HTL) and electron transport layer (ETL), respectively. The triple cation perovskite films are produced in a single step and for the sake of comparison, ultrasmooth and pinhole‐free absorbing layers are also fabricated using MAPbI3 perovskite. The triple cation perovskite cells exhibit champion power conversion efficiencies (PCEs) of 18.6% with high stabilized power conversion efficiency of 17.7% on rigid glass/indium tin oxide (ITO) substrates (comparing with 16.6% PCE with 16.1% stabilized output efficiency for the flexible polyethylene naphthalate (PEN)/thin film barrier/ITO substrates). More interestingly, the durability of flexible PSC under simulation of operative condition is proved. Over 85% of the maximum stabilized output efficiency is retained after 1000 h aging employing a thin MAPbI3 perovskite (over 90% after 500 h with a thick triple cation perovskite). This result is comparable to a similar state of the art rigid PSC and represents a breakthrough in the stability of flexible PSC using ETLs and HTLs compatible with roll to roll production speed, thanks to their room temperature processing. ...
Hierarchical Assembly of Nanocellulose‐Based Filaments by Interfacial Complexation
Small (IF 10.856) Pub Date : 2018-08-27 ,DOI:10.1002/smll.201801937
Kaitao Zhang; Henrikki Liimatainen
it is known, this is not only the first report about the fabrication of nanocellulose based filaments by interfacial complexation of cationic CNCs with anionic celluloses but also the first demonstration of fabricating continuous fibers directly from oppositely charged nanoparticles by interfacial nanoparticle ...
Recyclable magnetic nanoparticles grafted with antimicrobial metallopolymer-antibiotic bioconjugates
Biomaterials (IF 10.273) Pub Date : 2018-05-03 ,DOI:
Parasmani Pageni, Peng Yang, Marpe Bam, Tianyu Zhu, Yung Pin Chen, Alan W. Decho, Mitzi Nagarkatti, Chuanbing Tang
The enhanced antibacterial activity was a result of synergy of antimicrobial segments that facilitate the inhibition of hydrolysis of antibiotics and local enhancement of antibiotic concentration on a nanoparticlesurface. ...
Microfluidic Mass Production of Stabilized and Stealthy Liquid Metal Nanoparticles
Small (IF 10.856) Pub Date : 2018-04-22 ,DOI:10.1002/smll.201800118
Shi‐Yang Tang; Ruirui Qiao; Sheng Yan; Dan Yuan; Qianbin Zhao; Guolin Yun; Thomas P. Davis; Weihua Li
A novel nanoparticle‐stabilization approach is reported using brushed polyethylene glycol chains with trithiocarbonate end‐groups negating the requirements for thiol additives while imparting a “stealth” surface layer. ...
Size shrinkable drug delivery nanosystems and priming the tumor microenvironment for deep intratumoral penetration of nanoparticles
Journal of Controlled Release (IF 7.901) Pub Date : 2018-03-12 ,DOI:10.1016/j.jconrel.2018.03.012
Yimin Niu, Jianhua Zhu, Yang Li, Huihui Shi, Yaxiang Gong, Rui Li, Qiang Huo, Tao Ma, Yang Liu
In this review, we summarize and analyze recent research progress and challenges in promoting nanoparticle penetration based on two kinds of different strategies, which include size shrinkable nanoparticles and priming tumor microenvironments. ...
Sensing of Vimentin mRNA in 2D and 3D Models of Wounded Skin Using DNA‐Coated Gold Nanoparticles
Small (IF 10.856) Pub Date : 2018-02-21 ,DOI:10.1002/smll.201703489
Patrick Vilela; Amelie Heuer‐Jungemann; Afaf El‐Sagheer; Tom Brown; Otto L. Muskens; Neil R. Smyth; Antonios G. Kanaras
The method employs DNA‐coated gold nanoparticle fluorescent nanoprobes to sense the production of Vimentin mRNA expressed in mesenchymal cells. ...
Surfactant-free solubilization and systemic delivery of anti-cancer drug using low molecular weight methylcellulose
Journal of Controlled Release (IF 7.901) Pub Date : 2018-02-21 ,DOI:10.1016/j.jconrel.2018.02.028
Jee Young Chung, Jae Ho Ko, Ye Ji Lee, Hyung Seok Choi, Yong-Hee Kim
The in vivo anti-cancer effects of intravenously injected nanoparticle systems in B16F10 melanoma xenograft mice were evaluated and demonstrated a significantly enhanced therapeutic effect with the docetaxel-LMwMC micellar aggregates compared to a commercially available docetaxel, Taxotere®. ...
Crosstalk between core-multishell nanocarriers for cutaneous drug delivery and antigen-presenting cells of the skin
Biomaterials (IF 10.273) Pub Date : 2018-02-03 ,DOI:10.1016/j.biomaterials.2018.01.058
Alexander Edlich, Pierre Volz, Robert Brodwolf, Michael Unbehauen, Lars Mundhenk, Achim D. Gruber, Sarah Hedtrich, Rainer Haag, Ulrike Alexiev, Burkhard Kleuser
As CMS nanocarriers are able to penetrate into viable layers of normal and stripped human skin ex vivo as well as in in vitro skin disease models the understanding of nanoparticle crosstalk with components of the immune system requires thorough investigation. ...
Enhanced Sensitivity in Nanopore Sensing of Cancer Biomarkers in Human Blood via Click Chemistry
Small (IF 10.856) Pub Date : 2018-11-06 ,DOI:10.1002/smll.201804078
Zehui Zhang; Ting Li; Yingying Sheng; Lei Liu; Hai‐Chen Wu
Due to the amplification effects of nanoparticle loadings and the “click” reaction, the LOD of this strategy can be as low as the subfemtomolar level. ...
The application of nanotechnology in immune checkpoint blockade for cancer treatment
Journal of Controlled Release (IF 7.901) Pub Date : 2018-10-01 ,DOI:10.1016/j.jconrel.2018.09.026
Huan Deng, Zhiping Zhang
In this review, we mainly introduce the basic mechanisms of the immune checkpoint pathways and outline the recent successes of immune checkpoint blockade (ICB) therapy in combination with nanoparticle delivery system. ...
Quantum Dot–Based FRET Immunoassay for HER2 Using Ultrasmall Affinity Proteins
Small (IF 10.856) Pub Date : 05 August ,DOI:10.1002/smll.201802266
Yu‐Tang Wu; Xue Qiu; Sarah Lindbo; Kimihiro Susumu; Igor L. Medintz; Sophia Hober; Niko Hildebrandt
Although their very small sizes are beneficial for multivalent nanoparticle conjugation and efficient Förster resonance energy transfer (FRET), the application of engineered affinity proteins in such nanobiosensing formats has been largely neglected. ...
Mesenchymal stem cell-based drug delivery strategy: from cells to biomimetic
Journal of Controlled Release (IF 7.901) Pub Date : 2018-12-13 ,DOI:10.1016/j.jconrel.2018.12.019
Hong-Hui Wu, Yi Zhou, Yasuhiko Tabata, Jian-Qing Gao
Although nanoparticle-based drug delivery exhibits great potential, there are some challenges facing like rapid plasma clearance, triggering or aggravation of immune response, etc. ...
Cytotoxicity and Cellular Responses of Gold Nanorods to Smooth Muscle Cells Dependent on Surface Chemistry Coupled Action
Small (IF 10.856) Pub Date : 2018-11-14 ,DOI:10.1002/smll.201803715
Quanmei Sun; Xiaoli Shi; Jiantao Feng; Qiang Zhang; Zhuo Ao; Yinglu Ji; Xiaochun Wu; Dongsheng Liu; Dong Han
These findings highlight the importance of assessing nanoparticle cytotoxicity in somatic cells for medical applications. ...
Bioinspired and biomimetic systems for advanced drug and gene delivery
Journal of Controlled Release (IF 7.901) Pub Date : 2018-08-28 ,DOI:10.1016/j.jconrel.2018.08.033
Chinnu Sabu, Christine Rejo, Sabna Kotta, K. Pramod
Bioinspired or biomimetic macromolecular and nanoparticle-based drug and gene delivery systems are well studied. The bioinspired and biomimetic systems find great application in biomedicine. ...
Multifunctional melanin-like nanoparticles for bone-targeted chemo-photothermal therapy of malignant bone tumors and osteolysis
Biomaterials (IF 10.273) Pub Date : 2018-08-18 ,DOI:10.1016/j.biomaterials.2018.08.033
Yitong Wang, Quan Huang, Xiao He, Hui Chen, Yuan Zou, Yiwen Li, Kaili Lin, Xiaopan Cai, Jianru Xiao, Qiang Zhang, Yiyun Cheng
Here, we developed a multifunctional melanin-like nanoparticle for bone-targeted chemo-photothermal treatment of malignant bone tumors. ...
Contactless Stimulation and Control of Biomimetic Nanotubes by Calcium Ion Gradients
Small (IF 10.856) Pub Date : 2018-04-17 ,DOI:10.1002/smll.201703541
Vladimir Kirejev; Baharan Ali Doosti; Mehrnaz Shaali; Gavin D. M. Jeffries; Tatsiana Lobovkina
Furthermore, entrapment of polystyrene nanobeads within the bulge does not tamper the bulge movement and allows transporting of the nanoparticle cargo along the lipid nanotube. ...
Molecular bottlebrush as a unimolecular vehicle with tunable shape for photothermal cancer therapy
Biomaterials (IF 10.273) Pub Date : 2018-03-19 ,DOI:10.1016/j.biomaterials.2018.03.032
Huaan Li, Hong Liu, Tianqi Nie, Yi Chen, Zhiyong Wang, Huahua Huang, Lixin Liu, Yongming Chen
These results demonstrated an important role of nanoparticle shape on bio-behaviors and the unimolecular micelle could be a promising nanovehicle with precisely defined structure for biomedicine applications. ...
Red Phosphorus Nanoparticle@3D Interconnected Carbon Nanosheet Framework Composite for Potassium‐Ion Battery Anodes
Small (IF 10.856) Pub Date : 19 July 20 ,DOI:10.1002/smll.201802140
Peixun Xiong; Panxing Bai; Shuibin Tu; Mingren Cheng; Jinfeng Zhang; Jie Sun; Yunhua Xu
Red phosphorus (P) has been recognized as a promising storage material for Li and Na. However, it has not been reported for K storage and the reaction mechanism remains unknown. Herein, a novel nanocomposite anode material is designed and synthesized by anchoring red P nanoparticles on a 3D carbon nanosheet framework for K‐ion batteries (KIBs). The red P@CN composite demonstrates a superior electrochemical performance with a high reversible capacity of 655 mA h g−1 at 100 mA g−1 and a good rate capability remaining 323.7 mA h g−1 at 2000 mA g−1, which outperform reported anode materials for KIBs. The transmission electron microscopy and theoretical calculation results suggest a one‐electron reaction mechanism ofP + K+ + e−→ KP, corresponding to a theoretical capacity of 843 mA h g−1,which is the highest value for anode materials investigated for KIBs. The study not only sheds light on the rational design of high performance red P anodes for KIBs but also offers a fundamental understanding of the potassium storage mechanism of red P. ...
Dual‐Modality Surface‐Enhanced Resonance Raman Scattering and Multispectral Optoacoustic Tomography Nanoparticle Approach for Brain Tumor Delineation
Small (IF 10.856) Pub Date : 2018-05-04 ,DOI:10.1002/smll.201800740
Volker Neuschmelting; Stefan Harmsen; Nicolas Beziere; Hannah Lockau; Hsiao‐Ting Hsu; Ruimin Huang; Daniel Razansky; Vasilis Ntziachristos; Moritz F. Kircher
Difficulty in visualizing glioma margins intraoperatively remains a major issue in the achievement of gross total tumor resection and, thus, better clinical outcome of glioblastoma (GBM) patients. Here, the potential of a new combined optical + optoacoustic imaging method for intraoperative brain tumor delineation is investigated. A strategy using a newly developed gold nanostar synthesis method, Raman reporter chemistry, and silication method to produce dual‐modality contrast agents for combined surface‐enhanced resonance Raman scattering (SERRS) and multispectral optoacoustic tomography (MSOT) imaging is devised. Following intravenous injection of the SERRS‐MSOT‐nanostars in brain tumor bearing mice, sequential MSOT imaging is performed in vivo and followed by Raman imaging. MSOT is able to accurately depict GBMs three‐dimensionally with high specificity. The MSOT signal is found to correlate well with the SERRS images. Because SERRS enables uniquely sensitive high‐resolution surface detection, it could represent an ideal complementary imaging modality to MSOT, which enables real‐time, deep tissue imaging in 3D. This dual‐modality SERRS‐MSOT‐nanostar contrast agent reported here is shown to enable high precision depiction of the extent of infiltrating GBMs by Raman‐ and MSOT imaging in a clinically relevant murine GBM model and could pave new ways for improved image‐guided resection of brain tumors. ...
Nanoparticle co-delivery of wortmannin and cisplatin synergistically enhances chemoradiotherapy and reverses platinum resistance in ovarian cancer models
Biomaterials (IF 10.273) Pub Date : 2018-03-31 ,DOI:10.1016/j.biomaterials.2018.03.055
Maofan Zhang, C. Tilden Hagan IV, Yuangzeng Min, Hayley Foley, Xi Tian, Feifei Yang, Yu Mi, Kin Man Au, Yusra Medik, Kyle Roche, Kyle Wagner, Zachary Rodgers, Andrew Z. Wang
Most ovarian cancer patients respond well to initial platinum-based chemotherapy. However, within a year, many patients experience disease recurrence with a platinum resistant phenotype that responds poorly to second line chemotherapies. As a result, new strategies to address platinum resistant ovarian cancer (PROC) are needed. Herein, we report that NP co-delivery of cisplatin (CP) and wortmannin (Wtmn), a DNA repair inhibitor, synergistically enhances chemoradiotherapy (CRT) and reverses CP resistance in PROC. We encapsulated this regimen in FDA approved poly(lactic-co-glycolic acid)-poly(ethylene glycol) (PLGA-PEG) NPs to reduce systemic side effects, enhance cellular CP uptake, improve Wtmn stability, and increase therapeutic efficacy. Treatment of platinum-sensitive ovarian cancer (PSOC) and PROC murine models with these dual-drug loaded NPs (DNPs) significantly reduced tumor burden versus treatment with combinations of free drugs or single-drug loaded NPs (SNPs). These results support further investigation of this NP-based, synergistic drug regimen as a means to combat PROC in the clinic. ...
Oriented immobilization of a delicate glucose-sensing protein on silica nanoparticles
Biomaterials (IF 10.273) Pub Date : 2018-10-31 ,DOI:10.1016/j.biomaterials.2018.10.035
Arnold Leidner, Jens Bauer, Mojtaba Ebrahimi-Khonachah, Masanari Takamiya, Uwe Strähle, Thomas Dickmeis, Kersten S. Rabe, Christof M. Niemeyer
We believe that our results show generic strategies and provide essential guidelines for the development of protein-based nanoparticle sensors for applications in the life sciences. ...
Investigation on the Nucleation Stage of Palladium Nanoparticles Using a Microfluidic Droplet Generator Integrated with In Situ Sol‐Gel Quencher
Small (IF 10.856) Pub Date : 2018-10-21 ,DOI:10.1002/smll.201802851
Sunwoong Bae; Euiyoung Jung; Taekyung Yu; Tae Seok Seo
The nanoparticle (NP) synthesis undergoes stepwise processes starting from the input metal ions: nucleation, coalescence, ripening, and growth. ...
Gemcitabine nanoparticles promote antitumor immunity against melanoma
Biomaterials (IF 10.273) Pub Date : 2018-10-20 ,DOI:10.1016/j.biomaterials.2018.10.022
Yuan Zhang, Xin Bush, Bingfang Yan, Justin A. Chen
Here we describe a strategy to formulate a Gem analogue gemcitabine monophosphate (GMP) into a lipid-coated calcium phosphate (LCP) nanoparticle, and investigate its antitumor immunity and therapeutic effects after systemic administrations. ...
Photoacoustic and Magnetic Resonance Imaging Bimodal Contrast Agent Displaying Amplified Photoacoustic Signal
Small (IF 10.856) Pub Date : 2018-09-24 ,DOI:10.1002/smll.201800652
Yukun Duan; Yu Xu; Duo Mao; Weng Heng Liew; Bing Guo; Shaowei Wang; Xiaolei Cai; Nitish Thakor; Kui Yao; Chong‐Jing Zhang; Bin Liu
Herein, by integrating conjugated polymers (CPs) with iron oxide (IO) nanoparticles using an amphiphilic polymer, a bimodal contrast agent named CP‐IO is developed, displaying 45% amplified PA signal intensity as compared to bare CP nanoparticle, while the performance of MRI is not affected. ...
Tolerogenic Iron Oxide Nanoparticles in Type 1 Diabetes: Biodistribution and Pharmacokinetics Studies in Nonobese Diabetic Mice
Small (IF 10.856) Pub Date : 2018-09-05 ,DOI:10.1002/smll.201802053
Chloe Dubreil; Odile Sainte Catherine; Yoann Lalatonne; Clément Journé; Phalla Ou; Peter van Endert; Laurence Motte
Nanoparticle (NP) administration is among the most attractive approaches to exploit the synergy of different copackaged molecules for the same target. ...
Ultrathin Molybdenum Dioxide Nanosheets as Uniform and Reusable Surface‐Enhanced Raman Spectroscopy Substrates with High Sensitivity
Small (IF 10.856) Pub Date : 2018-08-16 ,DOI:10.1002/smll.201802276
Hongrong Wu; Xiaocheng Zhou; Jidong Li; Xuemei Li; Baowen Li; Wenwen Fei; Jianxin Zhou; Jun Yin; Wanlin Guo
More practically important, the planar MoO2 substrate is more robust than noble metals and shows excellent reusability and uniformity, which is usually prohibited for nanostructured or nanoparticle‐based metal oxide substrates. ...
Fluoropolymers for intracellular and in vivo protein delivery
Biomaterials (IF 10.273) Pub Date : 2018-08-09 ,DOI:10.1016/j.biomaterials.2018.08.023
Jia Lv, Bingwei He, Jingwen Yu, Yitong Wang, Changping Wang, Song Zhang, Hui Wang, Jingjing Hu, Qiang Zhang, Yiyun Cheng
The A6-2/saporin complex was further coated with a haluronic acid shell, and the yielding nanoparticleefficiently suppressed tumor growth in a breast cancer model by targeted protein delivery. ...
Dual drug delivery and sequential release by amphiphilic Janus nanoparticles for liver cancer theranostics
Biomaterials (IF 10.273) Pub Date : 2018-07-30 ,DOI:10.1016/j.biomaterials.2018.07.060
Lingyu Zhang, Manjie Zhang, Li Zhou, Qinghe Han, Xiangjun Chen, Shengnan Li, Lu Li, Zhongmin Su, Chungang Wang
Consequently, we explored a unique amphiphilic PCL-AuNC/Fe(OH)3-PAA Janus nanoparticle (JNP) to simultaneously preserve the hydrophilic drug (doxorubicin) and hydrophobic drug (docetaxel) in their distinct domains. ...
Confinement Impact for the Dynamics of Supported Metal Nanocatalyst
Small (IF 10.856) Pub Date : 08 June 20 ,DOI:10.1002/smll.201801586
Huimin Liu; Hui Wang; Zongwen Liu; Huajuan Ling; Cuifeng Zhou; Huawei Li; Catherine Stampfl; Xiaozhou Liao; Jiuling Wang; Xinghua Shi; Jun Huang
Direct observation of the dynamic processes of nanocatalysts at high temperatures and the confinement of supports is of great significance to investigate nanoparticle structure and functions for practical utilization. ...
Intravitreal implantable magnetic micropump for on-demand VEGFR-targeted drug delivery
Journal of Controlled Release (IF 7.901) Pub Date : 2018-05-28 ,DOI:10.1016/j.jconrel.2018.05.030
Cong Wang, Seung-Jun Seo, Jin-Seong Kim, Se-Hee Lee, Jae-Kun Jeon, Jae-Woo Kim, Ki-Hong Kim, Jong-Ki Kim, Jungyul Park
Precise on-demand drug release is realized by the deflection of the magnetic membrane assembly according to the external magnetic field, and the membrane assembly consists of a thin elastic polydimethylsiloxane (PDMS) membrane and a cylindrical magnetic nanoparticle-PDMS composite block. ...
Synergistic Targeting and Efficient Photodynamic Therapy Based on Graphene Oxide Quantum Dot‐Upconversion Nanocrystal Hybrid Nanoparticles
Small (IF 10.856) Pub Date : 2018-04-17 ,DOI:10.1002/smll.201800293
Yan Liu; Yawen Xu; Xiangshuai Geng; Yingying Huo; Dexin Chen; Kang Sun; Guangdong Zhou; Biqiong Chen; Ke Tao
Locating nanotherapeutics at the active sites, especially in the subcellular scale, is of great importance for nanoparticle‐based photodynamic therapy (PDT) and other nanotherapies. ...
Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy
Biomaterials (IF 10.273) Pub Date : 2018-03-27 ,DOI:10.1016/j.biomaterials.2018.03.046
Chuan Hu, Xinli Cun, Shaobo Ruan, Rui Liu, Wei Xiao, Xiaotong Yang, Yuanyuan Yang, Chuanyao Yang, Huile Gao
engineered by hyaluronidase (HAase)-triggered size shrinkable hyaluronic acid shells, which were modified with NIR laser sensitive nitric oxide donor (HN), small-sized dendrimeric prodrug (IDD) of doxorubicin (DOX) as chemotherapy agent and indocyanine green (ICG) as photothermal agent into a single nanoparticle ...
Nucleosome-inspired nanocarrier obtains encapsulation efficiency enhancement and side effects reduction in chemotherapy by using fullerenol assembled with doxorubicin
Biomaterials (IF 10.273) Pub Date : 2018-03-12 ,DOI:10.1016/j.biomaterials.2018.03.015
Jinglong Tang, Ruirui Zhang, Mengyu Guo, Leihou Shao, Ying Liu, Yuliang Zhao, Suojiang Zhang, Yan Wu, Chunying Chen
Inspired by the ability of eukaryote to package millions of genes in the nucleus wrapping and condensing DNA around histones to form chromosomes, here we developed a karyon-like hybrid nanoparticle to achieve ultra-high encapsulation of doxorubicin (Dox) with reduced side effects. ...
Liposomal Treatment of Cancer Cells Modulates Uptake Pathway of Polymeric Nanoparticles by Altering Membrane Stiffness
Small (IF 10.856) Pub Date : 2018-02-20 ,DOI:10.1002/smll.201704245
Shengnan Xiang; Melika Sarem; Samveg Shah; V. Prasad Shastri
While significant effort has focused on targeting pathway‐specific transporters, the role of nanobiophysics in the cell lipid bilayer nanoparticle uptake pathway remains largely unexplored. ...
Colorectal cancer lung metastasis treatment with polymer–drug nanoparticles
Journal of Controlled Release (IF 7.901) Pub Date : 2018-02-06 ,DOI:10.1016/j.jconrel.2018.02.008
Piotr Rychahou, Younsoo Bae, Derek Reichel, Yekaterina Y. Zaytseva, Eun Y. Lee, Dana Napier, Heidi L. Weiss, Nick Roller, Heather Frohman, Anh-Thu Le, B. Mark Evers
PNPs showed negligible accumulation in liver, spleen and kidneys, which was confirmed by fluorescent nanoparticle imaging and analysis of PI3K inhibition in the organs. ...
Near infrared-emitting persistent luminescent nanoparticles for Hepatocellular Carcinoma imaging and luminescence-guided surgery
Biomaterials (IF 10.273) Pub Date : 2018-02-03 ,DOI:10.1016/j.biomaterials.2018.01.031
Ting Ai, Wenting Shang, Hao Yan, Chaoting Zeng, Kun Wang, Yuan Gao, Tianpei Guan, Chihua Fang, Jie Tian
This new multi-modality nanoparticle has great potential for accurate liver cancer imaging and resection guidance. ...
Magnetic Nanoparticle Hyperthermia: Maximizing Specific Loss Power for Magnetic Hyperthermia by Hard–Soft Mixed Ferrites (Small 29/2018)
Small (IF 10.856) Pub Date : 2018-07-19 ,DOI:10.1002/smll.201870133
Shuli He; Hongwang Zhang; Yihao Liu; Fan Sun; Xiang Yu; Xueyan Li; Li Zhang; Lichen Wang; Keya Mao; Gangshi Wang; Yunjuan Lin; Zhenchuan Han; Renat Sabirianov; Hao Zeng
In article number 1800135, Hao Zeng and co‐workers design and develop biocompatible magnetic nanoparticles with maximized specific and intrinsic loss power, by alloying hard and soft ferrites to engineer their effective anisotropy. The very high intrinsic loss power enables a dilute solution of nanoparticles to be heated above the hyperthermia temperature within minutes at an ultralow AC magnetic field of 3 kA m−1. Bone cement incorporating low dosage of nanoparticles is heated efficiently. ...
CoNi2S4 Nanoparticle/Carbon Nanotube Sponge Cathode with Ultrahigh Capacitance for Highly Compressible Asymmetric Supercapacitor
Small (IF 10.856) Pub Date : 30 May 201 ,DOI:10.1002/smll.201800998
Xin Cao; Jin He; Huan Li; Liping Kang; Xuexia He; Jie Sun; Ruibing Jiang; Hua Xu; Zhibin Lei; Zong‐Huai Liu
Compared with other flexible energy‐storage devices, the design and construction of the compressible energy‐storage devices face more difficulty because they must accommodate large strain and shape deformations. In the present work, CoNi2S4 nanoparticles/3D porous carbon nanotube (CNT) sponge cathode with highly compressible property and excellent capacitance is prepared by electrodepositing CoNi2S4 on CNT sponge, in which CoNi2S4 nanoparticles with size among 10–15 nm are uniformly anchored on CNT, causing the cathode to show a high compression property and gives high specific capacitance of 1530 F g−1. Meanwhile, Fe2O3/CNT sponge anode with specific capacitance of 460 F g−1 in a prolonged voltage window is also prepared by electrodepositing Fe2O3 nanosheets on CNT sponge. An asymmetric supercapacitor (CoNi2S4/CNT//Fe2O3/CNT) is assembled by using CoNi2S4/CNT sponge as positive electrode and Fe2O3/CNT sponge as negative electrode in 2 m KOH solution. It exhibits excellent energy density of up to 50 Wh kg−1 at a power density of 847 W kg−1 and excellent cycling stability at high compression. Even at a strain of 85%, about 75% of the initial capacitance is retained after 10 000 consecutive cycles. The CoNi2S4/CNT//Fe2O3/CNT device is a promising candidate for flexible energy devices due to its excellent compressibility and high energy density. ...
Nanoparticle Self‐Assembly: Two‐Step Assembly of Thermoresponsive Gold Nanorods Coated with a Single Kind of Ligand (Small 14/2018)
Small (IF 10.856) Pub Date : 2018-04-06 ,DOI:10.1002/smll.201870060
Ryo Iida; Hideyuki Mitomo; Kenichi Niikura; Yasutaka Matsuo; Kuniharu Ijiro
In article number 1704230, Hideyuki Mitomo, Kuniharu Ijiro, and co‐workers introduce a thermoresponsive two‐step assembly of rod‐shaped gold nanoparticles (GNRs) by a simple surface modification with a single kind of ligand. As dehydration temperature of the surface ligand varies depending on the degree of curvature, GNRs form side‐by‐side assemblies first, and then form assembled‐assemblies on heating, providing hierarchical structures. ...
Neoadjuvant Chemotherapy Based on Abraxane/Human Neutrophils Cytopharmaceuticals with Radiotherapy for Gastric Cancer
Small (IF 10.856) Pub Date : 2018-12-14 ,DOI:10.1002/smll.201804191
Caoyun Ju; Yajing Wen; Luping Zhang; Qianqian Wang; Lingjing Xue; Jian Shen; Can Zhang
Human NEs, the most abundant white blood cells in peripheral blood, are developed to carry Abraxane, the commercial albumin‐bound paclitaxel nanoparticle, to form cytopharmaceuticals (Abraxane/NEs) which have been confirmed to maintain the intrinsic functions of human NEs. ...
Cellular Internalization–Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein‐Mediated Protection of Stem Cells
Small (IF 10.856) Pub Date : 2018-11-28 ,DOI:10.1002/smll.201804332
Shengcai Qi; Pengfei Zhang; Ming Ma; Minghua Yao; Jinjin Wu; Ermei Mäkilä; Jarno Salonen; Heikki Ruskoaho; Yuanzhi Xu; Hélder A. Santos; Hongbo Zhang
Here, a cell‐penetrating peptide (virus‐1 transactivator of transcription)–conjugated, porous silicon nanoparticle (TPSi NP) loaded with the Wnt3a protein to increase both the cell survival rate and the delivery precision of stem cell transplantation via a combinational theranostic strategy is presented ...
Rapid Growth Cone Uptake and Dynein‐Mediated Axonal Retrograde Transport of Negatively Charged Nanoparticles in Neurons Is Dependent on Size and Cell Type
Small (IF 10.856) Pub Date : 2018-11-22 ,DOI:10.1002/smll.201803758
Anna Lesniak; Devrim Kilinc; Agata Blasiak; George Galea; Jeremy C. Simpson; Gil U. Lee
These results show that the axonal retrograde transport of NPs depends on the endosomal pathway taken and establishes a means for screening nanoparticle‐based therapeutics for diseases that involve neurons. ...
Clay nanoparticles co-deliver three antigens to promote potent immune responses against pathogenic Escherichia coli
Journal of Controlled Release (IF 7.901) Pub Date : 2018-11-07 ,DOI:10.1016/j.jconrel.2018.11.008
Weiyu Chen, Huali Zuo, Barbara Rolfe, Mark A. Schembri, Rowland N. Cobbold, Bing Zhang, Timothy J. Mahony, Zhi Ping Xu
Notably, the multi-faceted immune responses elicited by the clay nanoparticle formulations were significantly higher than those induced by a QuilA formulation, without antigenic competition observed for the first time. ...
Mitochondria and plasma membrane dual-targeted chimeric peptide for single-agent synergistic photodynamic therapy
Biomaterials (IF 10.273) Pub Date : 2018-10-05 ,DOI:10.1016/j.biomaterials.2018.10.005
Hong Cheng, Rong-Rong Zheng, Gui-Ling Fan, Jing-Hao Fan, Lin-Ping Zhao, Xue-Yan Jiang, Bin Yang, Xi-Yong Yu, Shi-Ying Li, Xian-Zheng Zhang
Here, a single-agent self-delivery chimeric peptide based nanoparticle (designated as M-ChiP) was developed for mitochondria and plasma membrane dual-targeted photodynamic tumor therapy. ...
Iron oxide-carbon core-shell nanoparticles for dual-modal imaging-guided photothermal therapy
Journal of Controlled Release (IF 7.901) Pub Date : 2018-09-25 ,DOI:10.1016/j.jconrel.2018.09.022
Hui Wang, Qingxin Mu, Richard Revia, Kui Wang, Bowei Tian, Guanyou Lin, Woncheol Lee, Yang-Ki Hong, Miqin Zhang
Here, we report a bifunctional nanoparticle (BFNP, ∼16 nm) comprised of a magnetic Fe3O4 core (∼9.1 nm) covered by a fluorescent carbon shell (∼3.4 nm) and prepared via a one-pot solvothermal synthesis method using ferrocene as the sole source. ...
Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine
Biomaterials (IF 10.273) Pub Date : 2018-09-19 ,DOI:10.1016/j.biomaterials.2018.09.024
Wei Li, Yunzhan Li, Zehua Liu, Nattha Kerdsakundee, Ming Zhang, Feng Zhang, Xueyan Liu, Tomás Bauleth-Ramos, Wenhua Lian, Ermei Mäkilä, Marianna Kemell, Yaping Ding, Bruno Sarmento, Ruedeekorn Wiwattanapatapee, Jarno Salonen, Hongbo Zhang, Jouni T. Hirvonen, Dongfei Liu, Hélder A. Santos
Herein, we use hyaluronic acid functionalized porous silicon nanoparticle to bridge enzyme-responsive hydrogel and pH-responsive polymer, generating a hierarchical structured (nano-in-nano-in-micro) vehicle with programmed properties to fully and sequentially overcome the multiple obstacles for efficiently ...
Magnetic Nanoparticle Hyperthermia: Maximizing Specific Loss Power for Magnetic Hyperthermia by Hard–Soft Mixed Ferrites (Small 29/2018)
Small (IF 10.856) Pub Date : 2018-07-19 ,DOI:10.1002/smll.201870133
Shuli He; Hongwang Zhang; Yihao Liu; Fan Sun; Xiang Yu; Xueyan Li; Li Zhang; Lichen Wang; Keya Mao; Gangshi Wang; Yunjuan Lin; Zhenchuan Han; Renat Sabirianov; Hao Zeng
In article number 1800135, Hao Zeng and co‐workers design and develop biocompatible magnetic nanoparticles with maximized specific and intrinsic loss power, by alloying hard and soft ferrites to engineer their effective anisotropy. The very high intrinsic loss power enables a dilute solution of nanoparticles to be heated above the hyperthermia temperature within minutes at an ultralow AC magnetic field of 3 kA m−1. Bone cement incorporating low dosage of nanoparticles is heated efficiently. ...
CoNi2S4 Nanoparticle/Carbon Nanotube Sponge Cathode with Ultrahigh Capacitance for Highly Compressible Asymmetric Supercapacitor
Small (IF 10.856) Pub Date : 30 May 201 ,DOI:10.1002/smll.201800998
Xin Cao; Jin He; Huan Li; Liping Kang; Xuexia He; Jie Sun; Ruibing Jiang; Hua Xu; Zhibin Lei; Zong‐Huai Liu
Compared with other flexible energy‐storage devices, the design and construction of the compressible energy‐storage devices face more difficulty because they must accommodate large strain and shape deformations. In the present work, CoNi2S4 nanoparticles/3D porous carbon nanotube (CNT) sponge cathode with highly compressible property and excellent capacitance is prepared by electrodepositing CoNi2S4 on CNT sponge, in which CoNi2S4 nanoparticles with size among 10–15 nm are uniformly anchored on CNT, causing the cathode to show a high compression property and gives high specific capacitance of 1530 F g−1. Meanwhile, Fe2O3/CNT sponge anode with specific capacitance of 460 F g−1 in a prolonged voltage window is also prepared by electrodepositing Fe2O3 nanosheets on CNT sponge. An asymmetric supercapacitor (CoNi2S4/CNT//Fe2O3/CNT) is assembled by using CoNi2S4/CNT sponge as positive electrode and Fe2O3/CNT sponge as negative electrode in 2 m KOH solution. It exhibits excellent energy density of up to 50 Wh kg−1 at a power density of 847 W kg−1 and excellent cycling stability at high compression. Even at a strain of 85%, about 75% of the initial capacitance is retained after 10 000 consecutive cycles. The CoNi2S4/CNT//Fe2O3/CNT device is a promising candidate for flexible energy devices due to its excellent compressibility and high energy density. ...
Nanoparticle Self‐Assembly: Two‐Step Assembly of Thermoresponsive Gold Nanorods Coated with a Single Kind of Ligand (Small 14/2018)
Small (IF 10.856) Pub Date : 2018-04-06 ,DOI:10.1002/smll.201870060
Ryo Iida; Hideyuki Mitomo; Kenichi Niikura; Yasutaka Matsuo; Kuniharu Ijiro
In article number 1704230, Hideyuki Mitomo, Kuniharu Ijiro, and co‐workers introduce a thermoresponsive two‐step assembly of rod‐shaped gold nanoparticles (GNRs) by a simple surface modification with a single kind of ligand. As dehydration temperature of the surface ligand varies depending on the degree of curvature, GNRs form side‐by‐side assemblies first, and then form assembled‐assemblies on heating, providing hierarchical structures. ...
Neoadjuvant Chemotherapy Based on Abraxane/Human Neutrophils Cytopharmaceuticals with Radiotherapy for Gastric Cancer
Small (IF 10.856) Pub Date : 2018-12-14 ,DOI:10.1002/smll.201804191
Caoyun Ju; Yajing Wen; Luping Zhang; Qianqian Wang; Lingjing Xue; Jian Shen; Can Zhang
Human NEs, the most abundant white blood cells in peripheral blood, are developed to carry Abraxane, the commercial albumin‐bound paclitaxel nanoparticle, to form cytopharmaceuticals (Abraxane/NEs) which have been confirmed to maintain the intrinsic functions of human NEs. ...
Cellular Internalization–Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein‐Mediated Protection of Stem Cells
Small (IF 10.856) Pub Date : 2018-11-28 ,DOI:10.1002/smll.201804332
Shengcai Qi; Pengfei Zhang; Ming Ma; Minghua Yao; Jinjin Wu; Ermei Mäkilä; Jarno Salonen; Heikki Ruskoaho; Yuanzhi Xu; Hélder A. Santos; Hongbo Zhang
Here, a cell‐penetrating peptide (virus‐1 transactivator of transcription)–conjugated, porous silicon nanoparticle (TPSi NP) loaded with the Wnt3a protein to increase both the cell survival rate and the delivery precision of stem cell transplantation via a combinational theranostic strategy is presented ...
Rapid Growth Cone Uptake and Dynein‐Mediated Axonal Retrograde Transport of Negatively Charged Nanoparticles in Neurons Is Dependent on Size and Cell Type
Small (IF 10.856) Pub Date : 2018-11-22 ,DOI:10.1002/smll.201803758
Anna Lesniak; Devrim Kilinc; Agata Blasiak; George Galea; Jeremy C. Simpson; Gil U. Lee
These results show that the axonal retrograde transport of NPs depends on the endosomal pathway taken and establishes a means for screening nanoparticle‐based therapeutics for diseases that involve neurons. ...
Clay nanoparticles co-deliver three antigens to promote potent immune responses against pathogenic Escherichia coli
Journal of Controlled Release (IF 7.901) Pub Date : 2018-11-07 ,DOI:10.1016/j.jconrel.2018.11.008
Weiyu Chen, Huali Zuo, Barbara Rolfe, Mark A. Schembri, Rowland N. Cobbold, Bing Zhang, Timothy J. Mahony, Zhi Ping Xu
Notably, the multi-faceted immune responses elicited by the clay nanoparticle formulations were significantly higher than those induced by a QuilA formulation, without antigenic competition observed for the first time. ...
Mitochondria and plasma membrane dual-targeted chimeric peptide for single-agent synergistic photodynamic therapy
Biomaterials (IF 10.273) Pub Date : 2018-10-05 ,DOI:10.1016/j.biomaterials.2018.10.005
Hong Cheng, Rong-Rong Zheng, Gui-Ling Fan, Jing-Hao Fan, Lin-Ping Zhao, Xue-Yan Jiang, Bin Yang, Xi-Yong Yu, Shi-Ying Li, Xian-Zheng Zhang
Here, a single-agent self-delivery chimeric peptide based nanoparticle (designated as M-ChiP) was developed for mitochondria and plasma membrane dual-targeted photodynamic tumor therapy. ...
Iron oxide-carbon core-shell nanoparticles for dual-modal imaging-guided photothermal therapy
Journal of Controlled Release (IF 7.901) Pub Date : 2018-09-25 ,DOI:10.1016/j.jconrel.2018.09.022
Hui Wang, Qingxin Mu, Richard Revia, Kui Wang, Bowei Tian, Guanyou Lin, Woncheol Lee, Yang-Ki Hong, Miqin Zhang
Here, we report a bifunctional nanoparticle (BFNP, ∼16 nm) comprised of a magnetic Fe3O4 core (∼9.1 nm) covered by a fluorescent carbon shell (∼3.4 nm) and prepared via a one-pot solvothermal synthesis method using ferrocene as the sole source. ...
Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine
Biomaterials (IF 10.273) Pub Date : 2018-09-19 ,DOI:10.1016/j.biomaterials.2018.09.024
Wei Li, Yunzhan Li, Zehua Liu, Nattha Kerdsakundee, Ming Zhang, Feng Zhang, Xueyan Liu, Tomás Bauleth-Ramos, Wenhua Lian, Ermei Mäkilä, Marianna Kemell, Yaping Ding, Bruno Sarmento, Ruedeekorn Wiwattanapatapee, Jarno Salonen, Hongbo Zhang, Jouni T. Hirvonen, Dongfei Liu, Hélder A. Santos
Herein, we use hyaluronic acid functionalized porous silicon nanoparticle to bridge enzyme-responsive hydrogel and pH-responsive polymer, generating a hierarchical structured (nano-in-nano-in-micro) vehicle with programmed properties to fully and sequentially overcome the multiple obstacles for efficiently ...
Intradermal delivery of vaccine nanoparticles using hollow microneedle array generates enhanced and balanced immune response
Journal of Controlled Release (IF 7.901) Pub Date : 2018-12-17 ,DOI:10.1016/j.jconrel.2018.12.026
Lin Niu, Leonard Y. Chu, Scott A. Burton, Kris J. Hansen, Jayanth Panyam
Hollow microneedles can help overcome the skin permeation barrier imposed by the stratum corneum and facilitate transcutaneous delivery of nanoparticle delivery systems. ...
Responsive Upconversion Nanoprobe for Background‐Free Hypochlorous Acid Detection and Bioimaging
Small (IF 10.856) Pub Date : 2018-12-13 ,DOI:10.1002/smll.201803712
Run Zhang; Liuen Liang; Qingtao Meng; Jiangbo Zhao; Hang T. Ta; Li Li; Zhiqiang Zhang; Yasmina Sultanbawa; Zhi Ping Xu
Herein, a upconversional nanoparticle (UCNP)‐based nanoprobe, Ru@UCNPs, for specific sensing and imaging of hypochlorous acid (HOCl) is reported. ...
Quinic Acid‐Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins
Small (IF 10.856) Pub Date : 2018-11-09 ,DOI:10.1002/smll.201803601
Jun Xu; Steve Seung‐Young Lee; Howon Seo; Liang Pang; Yearin Jun; Ruo‐Yu Zhang; Zhong‐Yin Zhang; Pilhan Kim; Wooin Lee; Stephen J. Kron; Yoon Yeo
Current nanoparticle (NP) drug carriers mostly depend on the enhanced permeability and retention (EPR) effect for selective drug delivery to solid tumors. ...
ROS-sensitive thioketal-linked polyphosphoester-doxorubicin conjugate for precise phototriggered locoregional chemotherapy
Biomaterials (IF 10.273) Pub Date : 2018-10-11 ,DOI:10.1016/j.biomaterials.2018.10.010
Pei Pei, Chunyang Sun, Wei Tao, Jie Li, Xianzhu Yang, Jun Wang
Minimizing drug leakage at off-target sites and triggering sufficient drug release in tumor tissue are major objectives for effective nanoparticle (NP)-based cancer therapy. ...
Targeting of drug-loaded nanoparticles to tumor sites increases cell death and release of danger signals
Journal of Controlled Release (IF 7.901) Pub Date : 2018-07-04 ,DOI:10.1016/j.jconrel.2018.07.007
Magdalena Alev, Laura Egenberger, Laura Mühleisen, Bianca Weigel, Benjamin Frey, Ralf P. Friedrich, Marina Pöttler, Christoph Alexiou, Christina Janko
To reduce systemic side effects and to accumulate the drug exclusively in the tumor region, we developed an iron oxide nanoparticle-based system for the magnetically targeted delivery of mitoxantrone to the tumor, which has previously proven its long-term therapeutic efficacy in tumor bearing rabbits ...
Immobilization of Photo‐Immunoconjugates on Nanoparticles Leads to Enhanced Light‐Activated Biological Effects
Small (IF 10.856) Pub Date : 01 July 20 ,DOI:10.1002/smll.201800236
Huang‐Chiao Huang; Michael Pigula; Yanyan Fang; Tayyaba Hasan
It is further demonstrated that co‐delivery and light activation of BPD and FKR560 allow longitudinal fluorescence tracking of photoimmunoconjugate and nanoparticle in cells. ...
A minimal physiologically based pharmacokinetic model that predicts anti-PEG IgG-mediated clearance of PEGylated drugs in human and mouse
Journal of Controlled Release (IF 7.901) Pub Date : 2018-06-05 ,DOI:10.1016/j.jconrel.2018.06.002
M.D. McSweeney, T. Wessler, L.S.L. Price, E.C. Ciociola, L.B. Herity, W.C. Zamboni, M.G. Forest, Y. Cao, S.K. Lai
Circulating antibodies that specifically bind polyethylene glycol (PEG), a polymer routinely used in protein and nanoparticle therapeutics, have been associated with reduced efficacy and increased adverse reactions to some PEGylated therapeutics. ...
Focused ultrasound-enabled delivery of radiolabeled nanoclusters to the pons
Journal of Controlled Release (IF 7.901) Pub Date : 2018-06-01 ,DOI:10.1016/j.jconrel.2018.05.039
Dezhuang Ye, Deborah Sultan, Xiaohui Zhang, Yimei Yue, Gyu Seong Heo, Satya V.V.N. Kothapalli, Hannah Luehmann, Yuan-chuan Tai, Joshua B. Rubin, Yongjian Liu, Hong Chen
This drug delivery platform that integrates FUS, radiolabeled nanoclusters, and PET imaging provides a new strategy for noninvasive and localized nanoparticle delivery to the pons with concurrent in vivo quantitative imaging to evaluate delivery efficiency. ...
Nitroxide radical-containing nanoparticles attenuate tumorigenic potential of triple negative breast cancer
Biomaterials (IF 10.273) Pub Date : 2018-05-26 ,DOI:10.1016/j.biomaterials.2018.05.042
Babita Shashni, Yukio Nagasaki
Thus, the tumoricidal effects of RNPs are suggestive of insights on precedence of nanoparticle-based therapeutics over current low molecular weight antioxidants to curtail ROS-induced tumorigenesis of various cancers. ...
Photo-excitable hybrid nanocomposites for image-guided Photo/TRAIL synergistic cancer therapy
Biomaterials (IF 10.273) Pub Date : 2018-05-22 ,DOI:10.1016/j.biomaterials.2018.05.036
Gan Lin, Yang Zhang, Congqing Zhu, Chengchao Chu, Yesi Shi, Xin Pang, En Ren, Yayun Wu, Peng Mi, Haiping Xia, Xiaoyuan Chen, Gang Liu
In this study, we reported a micellar hybrid nanoparticle to carry TRAIL ligand (denoted as IPN@TRAIL) for a novel photo-excited TRAIL therapy. These IPN@TRAIL offered increased TRAIL stability, prolonged half-life and enhanced tumor accumulation, monitored by dual mode imaging. ...
Effective treatment of the primary tumor and lymph node metastasis by polymeric micelles with variable particle sizes
Journal of Controlled Release (IF 7.901) Pub Date : 2018-04-30 ,DOI:
Ling Mei, Jingdong Rao, Yayuan Liu, Man Li, Zhirong Zhang, Qin He
The strategy resulted in improved retention of the micelles in 4 T1 cells both in vitro and in vivo owing to the decreasing of nanoparticle exocytosis and minimizing the backflow to the bloodstream. Enhanced cytotoxicity on 4 T1 cells and improved antitumor efficacy were also observed. ...
Photothermal Therapy Generates a Thermal Window of Immunogenic Cell Death in Neuroblastoma
Small (IF 10.856) Pub Date : 2018-04-17 ,DOI:10.1002/smll.201800678
Elizabeth E. Sweeney; Juliana Cano‐Mejia; Rohan Fernandes
A thermal “window” of immunogenic cell death (ICD) elicited by nanoparticle‐based photothermal therapy (PTT) in an animal model of neuroblastoma is described. ...
Cargo-free particles of ammonio methacrylate copolymers: From pharmaceutical inactive ingredients to effective anticancer immunotherapeutics
Biomaterials (IF 10.273) Pub Date : 2018-03-02 ,DOI:10.1016/j.biomaterials.2018.02.053
Maryam Alsadat Shetab Boushehri, Valentin Stein, Alf Lamprecht
Within the context of cancer immunotherapy, biweekly peritumoral nanoparticle injection led to a complete regression of the syngeneic colorectal tumor, or a significant growth retardation thereof, considerably extending the survival of tumor-bearing animals. ...
Polymeric nanoparticles encapsulating novel TLR7/8 agonists as immunostimulatory adjuvants for enhanced cancer immunotherapy
Biomaterials (IF 10.273) Pub Date : 2018-02-17 ,DOI:10.1016/j.biomaterials.2018.02.034
Hyunjoon Kim, Lin Niu, Peter Larson, Tamara A. Kucaba, Katherine A. Murphy, Britnie R. James, David M. Ferguson, Thomas S. Griffith, Jayanth Panyam
Importantly, our studies demonstrate significant reductions in systemic metastasis with the nanoparticlevaccine. Our results suggest novel TLR 7/8 agonist-encapsulated nanoparticles are potent immunostimulatory adjuvants for cancer immunotherapy. ...
Dynamically PEGylated and Borate‐Coordination‐Polymer‐Coated Polydopamine Nanoparticles for Synergetic Tumor‐Targeted, Chemo‐Photothermal Combination Therapy
Small (IF 10.856) Pub Date : 2018-02-12 ,DOI:10.1002/smll.201703968
Shucheng Liu; Jianming Pan; Jinxin Liu; Yue Ma; Fengxian Qiu; Lin Mei; Xiaowei Zeng; Guoqing Pan
In this work, a synergetic tumor‐targeted, chemo‐photothermal combined therapeutic nanoplatform based on a dynamically PEGylated, borate‐coordination‐polymer‐coated polydopamine nanoparticle(PDA@CP‐PEG) is developed. ...
Self-indicating, fully active pharmaceutical ingredients nanoparticles (FAPIN) for multimodal imaging guided trimodality therapy
Biomaterials (IF 10.273) Pub Date : 2018-02-03 ,DOI:10.1016/j.biomaterials.2018.01.044
Xiangdong Xue, Yee Huang, Xinshuai Wang, Zhongling Wang, Randy P. Carney, Xiaocen Li, Ye Yuan, Yixuan He, Tzu-yin Lin, Yuanpei Li
The nanoparticle itself was composed of 100% imaging agents, so that the stability, drug release, subcellular dispositions, biodistribution and therapeutic efficacy of FAPINs can be readily visualized by ample imaging capacities, including energy transfer relay dominated, dual-color fluorogenic property ...
Natural killer cell membrane infused biomimetic liposomes for targeted tumor therapy
Biomaterials (IF 10.273) Pub Date : 2018-01-16 ,DOI:10.1016/j.biomaterials.2018.01.018
Arunkumar Pitchaimani, Tuyen Duong Thanh Nguyen, Santosh Aryal
A drawing attention has been given to a biomimetic cloaking of the synthetic drug delivery nanoparticleusing mammalian cell-ghosts, which has shown the installment of the biological complexity of the original cells thereby acting as naïve cells, to precisely delivery drug to the intended target. ...
Timely Visualization of the Collaterals Formed during Acute Ischemic Stroke with Fe3O4 Nanoparticle‐based MR Imaging Probe
Small (IF 10.856) Pub Date : 2018-04-17 ,DOI:10.1002/smll.201800573
Ting Wang; Yi Hou; Bo Bu; Wenxin Wang; Tiancong Ma; Chunyan Liu; Lan Lin; Lin Ma; Xin Lou; Mingyuan Gao
Ischemic stroke is one of the major leading causes for long‐term disability and mortality. Collateral vessels provide an alternative pathway to protect the brain against ischemic injury after arterial occlusion. Aiming at visualizing the collaterals occurring during acute ischemic stroke, an integrin αvβ3‐specific Fe3O4–Arg‐Gly‐Asp (RGD) nanoprobe is prepared for magnetic resonance imaging (MRI) of the collaterals. Rat models are constructed by occluding the middle cerebral artery for imaging studies of cerebral ischemia and ischemia–reperfusion on 7.0 Tesla MRI using susceptibility‐weighted imaging sequence. To show the binding specificity to the collaterals, the imaging results acquired with the Fe3O4–RGD nanoprobe and the Fe3O4 mother nanoparticles, respectively, are carefully compared. In addition, an RGD blocking experiment is also carried out to support the excellent binding specificity of the Fe3O4–RGD nanoprobe. Following the above experiments, cerebral ischemia–reperfusion studies show the collateral dynamics upon reperfusion, which is very important for the prognosis of various revascularization therapies in the clinic. The current study has, for the first time, enabled the direct observation of collaterals in a quasi‐real time fashion and further disclosed that the antegrade flow upon reperfusion dominates the blood supply of primary ischemic tissue during the early stage of infarction, which is significantly meaningful for clinical treatment of stroke. ...
Dye‐Anchored MnO Nanoparticles Targeting Tumor and Inducing Enhanced Phototherapy Effect via Mitochondria‐Mediated Pathway
Small (IF 10.856) Pub Date : 2018-08-10 ,DOI:10.1002/smll.201801008
Lihua Zhou; Yayun Wu; Xiaoqing Meng; Sanpeng Li; Jiali Zhang; Ping Gong; Pengfei Zhang; Tao Jiang; Guanjun Deng; Wenjun Li; Zhihong Sun; Lintao Cai
Herein, a mitochondrial‐targeted multifunctional dye‐anchored manganese oxide nanoparticle(IR808@MnO NP) is developed for enhancing phototherapy of cancer. ...
Bioengineered stem cell membrane functionalized nanocarriers for therapeutic targeting of severe hindlimb ischemia
Biomaterials (IF 10.273) Pub Date : 2018-08-09 ,DOI:10.1016/j.biomaterials.2018.08.018
Rajendran JC. Bose, Byoung Ju Kim, Yoshie Arai, In-bo Han, James J. Moon, Ramasamy Paulmurugan, Hansoo Park, Soo-Hong Lee
The reported strategy could be used to create biocompatible and custom-tailored biomimetic nanoparticles with various hybrid functionalities, which may overcome the limitations of current nanoparticle-based therapeutic and imaging platforms. ...
Folate-conjugated nanobubbles selectively target and kill cancer cells via ultrasound-triggered intracellular explosion
Biomaterials (IF 10.273) Pub Date : 2018-07-30 ,DOI:10.1016/j.biomaterials.2018.07.030
Shuxin Shen, Ying Li, Yunbin Xiao, Zonglei Zhao, Chuanxi Zhang, Junfen Wang, Hairui Li, Feng Liu, Nvqin He, Ye Yuan, Yongkang Lu, Shengcun Guo, Yan Wang, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin
With the rapid development of cancer-targeted nanotechnology, a variety of nanoparticle-based drug delivery systems have clinically been employed in cancer therapy. However, multidrug resistance significantly impacts the therapeutic efficacy. ...
NIR-controlled morphology transformation and pulsatile drug delivery based on multifunctional phototheranostic nanoparticles for photoacoustic imaging-guided photothermal-chemotherapy
Biomaterials (IF 10.273) Pub Date : 2018-05-21 ,DOI:10.1016/j.biomaterials.2018.05.033
Jun Yang, Shaodong Zhai, Huan Qin, He Yan, Da Xing, Xianglong Hu
When laser is switched off, the discontinued photothermal generation makes the nanoparticle shrink back, thereby avoiding the leakage of CPT and DOX. ...
pH protective Y1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time
Biomaterials (IF 10.273) Pub Date : 2018-04-04 ,DOI:10.1016/j.biomaterials.2018.04.002
Zhenqi Jiang, Yuchen Tian, Dingying Shan, Yinjie Wang, Ethan Gerhard, Jianbi Xia, Rong Huang, Yan He, Aiguo Li, Jianchao Tang, Huimin Ruan, Yong Li, Juan Li, Jian Yang, Aiguo Wu
Nanoparticle-based tumor therapies are extensively studied; however, few are capable of improving patient survival time due to premature drug leakage, off target effects, and poor tissue penetration. ...
Ocular drug delivery targeted by iontophoresis in the suprachoroidal space using a microneedle
Journal of Controlled Release (IF 7.901) Pub Date : 2018-03-02 ,DOI:
Jae Hwan Jung, Bryce Chiang, Hans E. Grossniklaus, Mark R. Prausnitz
Injection of nanoparticles into the SCS of the rabbit eye ex vivo without iontophoresis led to a nanoparticle distribution mostly localized at the site of injection near the limbus and <15% of nanoparticles delivered to the most posterior region of SCS (>9 mm from the limbus). ...
Reactive oxygen species-responsive nanoprodrug with quinone methides-mediated GSH depletion for improved chlorambucil breast cancers therapy
Journal of Controlled Release (IF 7.901) Pub Date : 2018-02-02 ,DOI:10.1016/j.jconrel.2018.01.034
Cheng-Qiong Luo, Yu-Xin Zhou, Tian-Jiao Zhou, Lei Xing, Peng-Fei Cui, Minjie Sun, Liang Jin, Na Lu, Hu-Lin Jiang
The prodrug could form core-shell nanoparticle and possess high stability during storage. Drug release profile of PPAHC nanoprodrug demonstrated that nature CHL could be quickly released from PPAHC nanoprodrug in the presence of hydrogen peroxide (H2O2). ...
Hyaluronic acid-endostatin2-alft1 (HA-ES2-AF) nanoparticle-like conjugate for the target treatment of diseases
Journal of Controlled Release (IF 7.901) Pub Date : 2018-08-29 ,DOI:10.1016/j.jconrel.2018.08.038
Feng Sun, Yang Yu, Zhifang Yang, Zhendong Wang, Yan Li, Fengshan Wang, Haining Tan
Anti-flt1 peptide (GNQWFI, AF) specifically binds to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1), thereby inhibiting the interaction of VEGFR1 with a series of ligands. ES2 (IVRRADRAAVP) can effectively inhibit the proliferation and invasion of endothelial cells and play a key role in anti-angiogenesis. AF and ES2 peptides differ in their activity. To better exploit the advantages of both, we designed a new peptide called ES2-AF (IVRRADRAAVPGGGGGGNQWFI). Hyaluronic acid (HA) is widely used in the pharmaceutical industry because of its biodegradable and high load performance. The HA-specific cell surface receptor CD44 was highly expressed in the tumour site during the anti-tumour study. Therefore, we used HA as a modifier to chemically modify ES2-AF; it was expected that the modified compound would have preferable solubility, stronger targeting, longer half-life, and better anti-angiogenesis effects in vivo. In this study, the anti-proliferative, anti-migration and targeting activities of HA-ES2-AF in vitro were studied by MTT, ELISA, transwell and SPR assays. Meanwhile, the anti-neovascularization activity of HA-ES2-AF in vivo was studied by CAM assay, and the targeting of HA-ES2-AF to tumour tissue was studied by bioimaging techniques. Finally, we also studied the half-life of HA-ES2-AF in vivo. In short, the bioactivity of the new peptide ES2-AF was enhanced to a certain extent, and ES2-AF modified by HA had higher anti-neovascularization activity in vitro and in vivo, had stronger targeting to tumour tissue, and had a significantly prolonged half-life in vivo. These results laid the foundation for its further development into targeting anti-tumour drugs. ...
Theranostic size-reducible and no donor conjugated gold nanocluster fabricated hyaluronic acid nanoparticle with optimal size for combinational treatment of breast cancer and lung metastasis
Journal of Controlled Release (IF 7.901) Pub Date : 2018-04-07 ,DOI:
Rui Liu, Wei Xiao, Chuan Hu, Rou Xie, Huile Gao
The size of nanoparticles plays a key role in utilizing enhanced permeability and retention (EPR) effect of tumor, where large-sized nanoparticles possess good retention but poor penetration, while small-sized nanoparticles are on the contrary. Although size-reducible nanoparticles have been designed to partially overcome this dilemma, the initial size and complicated tumor microenvironment remain restricting the tumor distribution of nanoparticles. Herein, we employed tumor-specific CD44 targeted, hyaluronidase-degradable hyaluronic acid (HA) and small-sized, renal-clearable, red emission, cationic bovine serum albumin-protected gold nanocluster (AuNC@CBSA) to successfully construct size-reducible nanoplatform (AuNC@CBSA@HA). By changing the ratio of HA and AuNC@CBSA, different initial sizes of AuNC@CBSA@HA were prepared and their tumor targeting efficiencies, pharmacokinetic profiles were evaluated. Then 200 nm of AuNC@CBSA@HA with optimal EPR effect was screened out to further load paclitaxel (PTX) and indocyanine green (ICG) for chemo- photothermal therapy and nitric oxide (NO) for modulating tumor microenvironment and enhancing drug delivery. The AuNC@CBSA-PTX-ICG@HA-NO3 showed size-reducible ability under triggering by hyaluronidase and high accumulation in breast cancer with homogenous intra-tumor distribution, suppressed 95.3% of in-situ tumor growth and inhibited 88.4% of lung metastasis growth. In conclusion, we provide a strategy that fully satisfied the concerns in drug delivery to tumor for improved antitumor effect. ...
In vivo hepatocellular expression of interleukin-22 using penetratin-based hybrid nanoparticles as potential anti-hepatitis therapeutics
Biomaterials (IF 10.273) Pub Date : 2018-10-03 ,DOI:10.1016/j.biomaterials.2018.09.046
Wei Chen, Jingyun Luan, Gang Wei, Xuyao Zhang, Jiajun Fan, Wenjing Zai, Shaofei Wang, Yichen Wang, Yanxu Liang, Yanyang Nan, Chuzhen Yin, Yubin Li, Ming-lin Liu, Dianwen Ju
Accordingly, we developed a polypeptide penetratin-based hybrid nanoparticle system (PDPIA) carrying IL-22 gene by a self-assembly process. ...
A filter-free blood-brain barrier model to quantitatively study transendothelial delivery of nanoparticles by fluorescence spectroscopy
Journal of Controlled Release (IF 7.901) Pub Date : 2018-09-20 ,DOI:10.1016/j.jconrel.2018.09.015
Edwin De Jong, David S. Williams, Loai K.E.A. Abdelmohsen, Jan C.M. Van Hest, Inge S. Zuhorn
Our data confirm the effectiveness of the G23 peptide to mediate transport of polymersomes across the BBB and the suitability of this filter-free in vitro model for quantification of nanoparticle transcytosis. ...
Ultra-high FRET efficiency NaGdF4: Tb3+-Rose Bengal biocompatible nanocomposite for X-ray excited photodynamic therapy application
Biomaterials (IF 10.273) Pub Date : 2018-09-05 ,DOI:10.1016/j.biomaterials.2018.09.001
Wenli Zhang, Xiaofeng Zhang, Yingli Shen, Feng Shi, Chaojun Song, Tianshuai Liu, Peng Gao, Bin Lan, Miao Liu, Sicheng Wang, Li Fan, Hongbing Lu
However, the high X-ray dosage used and non-specific cytotoxicity of the nanoparticle-photosensitizer nanocomposite (NPs-PS) hamper in-vivo X-PDT applications. ...
Hypoxia-responsive block copolymer radiosensitizers as anticancer drug nanocarriers for enhanced chemoradiotherapy of bulky solid tumors
Biomaterials (IF 10.273) Pub Date : 2018-08-04 ,DOI:10.1016/j.biomaterials.2018.08.014
Wei Yin, Ming Qiang, Wendong Ke, Yu Han, Jean Felix Mukerabigwi, Zhishen Ge
Herein, amphiphilic block copolymer radiosensitizers are prepared from clinically approved poly(ethylene glycol)-block-poly(L-glutamic acid) (PEG-b-PLG) and metronidazole (MN) to obtain MN-grafted PEG-b-PLG (PEG-b-P(LG-g-MN)) via condensation reaction, which can self-assemble into core-shell micelles as nanoparticle-formulated ...
Physicochemical, pharmacokinetic and pharmacodynamic analyses of amphiphilic cyclodextrin-based nanoparticles designed to enhance intestinal delivery of insulin
Journal of Controlled Release (IF 7.901) Pub Date : 2018-07-31 ,DOI:10.1016/j.jconrel.2018.07.045
Elena Presas, Fiona McCartney, Eric Sultan, Corina Hunger, Sabine Nellen, Clara V. Alvarez, Ulrich Werner, Didier Bazile, David J. Brayden, Caitriona M. O'Driscoll
Nanoparticle (NP) formulations have potential to overcome the barriers to oral peptide delivery through protecting the payload and increasing bioavailability. ...
Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo
Biomaterials (IF 10.273) Pub Date : 2018-03-19 ,DOI:10.1016/j.biomaterials.2018.03.031
Philipp Michael Klein, Sarah Kern, Dian-Jang Lee, Johannes Schmaus, Miriam Höhn, Jan Gorges, Uli Kazmaier, Ernst Wagner
A bivalent DBCO surface agent with a PEG24 spacer was identified as the optimal formulation in terms of nanoparticle size, folate receptor (FR) targeting, cellular uptake and gene silencing in vitro. ...
Dual-stimuli-responsive albumin-polyplex nanoassembly for spatially controlled gene release in metastatic breast cancer
Journal of Controlled Release (IF 7.901) Pub Date : 2018-02-28 ,DOI:10.1016/j.jconrel.2018.02.039
Santhosh Kalash Rajendrakumar, Kondareddy Cherukula, Hyeong Ju Park, Saji Uthaman, Yong Yeon Jeong, Byeong-Il Lee, In-Kyu Park
We formulated a nanoassembly comprising a disulfide-crosslinked polyethylenimine (ssPEI) conjugated with a tumor-specific cell-penetrating peptide (DS 4-3) (SPD) polyplex and bovine serum albumin (BSA)-loaded IR780 (BI) nanoparticle, thereby forming a dual-stimulus-triggered, tumor-penetrating and gene-carrying ...
Bacteria-like mesoporous silica-coated gold nanorods for positron emission tomography and photoacoustic imaging-guided chemo-photothermal combined therapy
Biomaterials (IF 10.273) Pub Date : 2018-02-23 ,DOI:10.1016/j.biomaterials.2018.02.043
Cheng Xu, Feng Chen, Hector F. Valdovinos, Dawei Jiang, Shreya Goel, Bo Yu, Haiyan Sun, Todd E. Barnhart, James J. Moon, Weibo Cai
Mesoporous silica nanoshell (MSN) coating has been demonstrated as a versatile surface modification strategy for various kinds of inorganic functional nanoparticles, such as gold nanorods (GNRs), to achieve not only improved nanoparticle stability but also concomitant drug loading capability. ...
Image guided thermosensitive liposomes for focused ultrasound drug delivery: Using NIRF labelled lipids and topotecan to visualise the effects of hyperthermia in tumours
Journal of Controlled Release (IF 7.901) Pub Date : 2018-05-01 ,DOI:10.1016/j.jconrel.2018.04.047
Miguel N. Centelles, Michael Wright, Po-Wah So, Maral Amrahli, Xiao Yun Xu, Justin Stebbing, Andrew D. Miller, Wladyslaw Gedroyc, Maya Thanou
It is suggested that sub-ablative hyperthermia significantly modifies the permeability of tumour vasculature and enhances nanoparticle uptake. ...
MRI Probes: Timely Visualization of the Collaterals Formed during Acute Ischemic Stroke with Fe3O4 Nanoparticle‐based MR Imaging Probe (Small 23/2018)
Small (IF 10.856) Pub Date : 2018-06-07 ,DOI:10.1002/smll.201870108
Ting Wang; Yi Hou; Bo Bu; Wenxin Wang; Tiancong Ma; Chunyan Liu; Lan Lin; Lin Ma; Xin Lou; Mingyuan Gao
In article number 1800573 by Xin Lou and co‐workers, an αvβ3‐specific Fe3O4‐RGD nanoprobe is prepared for in vivo magnetic resonance imaging of the collaterals after cerebral ischemia, and shows the binding specificity to the cerebral collaterals. The direct observation of cerebral collaterals is enabled in a quasi‐real time fashion, and further studies are also performed to show the collateral dynamics upon reperfusion, which is significantly meaningful for clinical treatment of stroke. ...
Nanotherapeutic provides dose sparing and improved antimicrobial activity against Brucella melitensis infections
Journal of Controlled Release (IF 7.901) Pub Date : 2018-12-17 ,DOI:10.1016/j.jconrel.2018.12.024
Paul Lueth, Shannon L. Haughney, Andrea M. Binnebose, Adam S. Mullis, Nathan Peroutka-Bigus, Balaji Narasimhan, Bryan H. Bellaire
Treatment of infected BALB/c mice with a nanoparticle cocktail containing doxycycline and rifampicin for five days decreased bacterial burden by three log10 in the liver. ...
A hepatic pDNA delivery system based on an intracellular environment sensitive vitamin E-scaffold lipid-like material with the aid of an anti-inflammatory drug
Journal of Controlled Release (IF 7.901) Pub Date : 2018-04-17 ,DOI:
Ryohei Togashi, Hiroki Tanaka, Sakiko Nakamura, Hideo Yokota, Kota Tange, Yuta Nakai, Hiroki Yoshioka, Hideyoshi Harashima, Hidetaka Akita
The hepatic transgene expression of the intravenously administrated lipid nanoparticle (LNP) that was formed with the ssPalmE-Paz4-C2 (LNPssPalmE-Paz4-C2) was significantly higher than that of conventional LNPs formed with a myristic acid-scaffold ssPalm (LNPssPalmM). ...
Biosynthesis and Characterization of Copper Nanoparticles Using Shewanella oneidensis: Application for Click Chemistry
Small (IF 10.856) Pub Date : 2018-01-23 ,DOI:10.1002/smll.201703145
Richard L. Kimber, Edward A. Lewis, Fabio Parmeggiani, Kurt Smith, Heath Bagshaw, Toby Starborg, Nimisha Joshi, Adriana I. Figueroa, Gerrit van der Laan, Giannantonio Cibin, Diego Gianolio, Sarah J. Haigh, Richard A. D. Pattrick, Nicholas J. Turner, Jonathan R. Lloyd
This work demonstrates a novel, simple, green biosynthesis method for producing efficient copper nanoparticle catalysts. A novel green biosynthesis route for the production of functional copper nanoparticles (Cu-NPs) using a metal-reducing bacterium is reported. ...
Enhancement of antitumor potency of extracellular vesicles derived from natural killer cells by IL-15 priming
Biomaterials (IF 10.273) Pub Date : 2018-10-29 ,DOI:10.1016/j.biomaterials.2018.10.034
Liya Zhu, Senthilkumar Kalimuthu, Ji Min Oh, Prakash Gangadaran, Se Hwan Baek, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
In addition, NK-EVs and NK-EVsIL-15 were characterized by transmission electron microscopy, nanoparticle-tracking analysis, and western blotting. ...
Near-infrared light-controlled regulation of intracellular calcium to modulate macrophage polarization
Biomaterials (IF 10.273) Pub Date : 2018-04-21 ,DOI:10.1016/j.biomaterials.2018.03.007
Heemin Kang, Kunyu Zhang, Dexter Siu Hong Wong, Fengxuan Han, Bin Li, Liming Bian
In this study, we developed an upconversion nanoparticle (UCNP)-based photoresponsive nanocarrier for near-infrared (NIR) light-mediated control of intracellular calcium levels to regulate macrophage polarization. ...
Near-infrared light-controlled regulation of intracellular calcium to modulate macrophage polarization
Biomaterials (IF 10.273) Pub Date : 2018-04-21 ,DOI:
Heemin Kang, Kunyu Zhang, Dexter Siu Hong Wong, Fengxuan Han, Bin Li, Liming Bian
In this study, we developed an upconversion nanoparticle (UCNP)-based photoresponsive nanocarrier for near-infrared (NIR) light-mediated control of intracellular calcium levels to regulate macrophage polarization. ...
Dual-responsive polyplexes with enhanced disassembly and endosomal escape for efficient delivery of siRNA
Biomaterials (IF 10.273) Pub Date : 2018-02-03 ,DOI:10.1016/j.biomaterials.2018.01.042
Jia Zhu, Mingxi Qiao, Qi Wang, Yuqing Ye, Shuang Ba, Jingjing Ma, Haiyang Hu, Xiuli Zhao, Dawei Chen
Despite the extracellular barriers for siRNA delivery have been overcome by utilizing advanced nanoparticle delivery systems, the key intracellular barriers after internalization including efficient disassembly of siRNA and endosomal escape still remains challenging. ...
Patterning Graphene Surfaces with Iron-Oxide-Embedded Mesoporous Polypyrrole and Derived N-Doped Carbon of Tunable Pore Size
Small (IF 10.856) Pub Date : 2018-01-11 ,DOI:10.1002/smll.201702755
Shuyan Zhu, Hao Tian, Nan Wang, Bin Chen, Yiyong Mai, Xinliang Feng
The resultant 2D nanohybrids possess a sandwich-like structure with Fe2O3 nanoparticle-embedded mesoporous polypyrrole (PPy) monolayers grown on both sides of reduced graphene oxide (rGO) nanosheets (denoted as mPPy-Fe2O3@rGO). ...
Biocompatible bacteria-derived vesicles show inherent antimicrobial activity
Journal of Controlled Release (IF 7.901) Pub Date : 2018-10-05 ,DOI:10.1016/j.jconrel.2018.09.030
Eilien Schulz, Adriely Goes, Ronald Garcia, Fabian Panter, Marcus Koch, Rolf Müller, Kathrin Fuhrmann, Gregor Fuhrmann
Incorporation of antibiotics into nanoparticle drug carriers (“nanoantibiotics”) is currently investigated as a promising strategy to make existing antibiotics regain antimicrobial strength and overcome certain types of microbial drug resistance. ...
Tumor hypoxia directed multimodal nanotherapy for overcoming drug resistance in renal cell carcinoma and reprogramming macrophages
Biomaterials (IF 10.273) Pub Date : 2018-08-30 ,DOI:10.1016/j.biomaterials.2018.08.053
Hashem O. Alsaab, Samaresh Sau, Rami M. Alzhrani, Vino T. Cheriyan, Lisa A. Polin, Ulka Vaishampayan, Arun K. Rishi, Arun K. Iyer
To alleviate the drug resistance, we have used Sorafenib (Sor) in combination with tumor hypoxia directed nanoparticle (NP) loaded with a new class of apoptosis inducer, CFM 4.16 (C4.16), namely CA IX-C4.16. ...
Cell-Promoted Nanoparticle Aggregation Decreases Nanoparticle-Induced Hyperthermia under an Alternating Magnetic Field Independently of Nanoparticle Coating, Core Size, and Subcellular Localization
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-20 ,DOI:10.1021/acsami.8b18451
Raquel Mejías, Patricia Hernández Flores, Marina Talelli, José L. Tajada-Herráiz, María E.F. Brollo, Yadileiny Portilla, María P. Morales, Domingo F. Barber
Our results indicate that the cell–nanoparticle interaction reduces the cytotoxic effects of magnetic hyperthermia, independent of nanoparticle coating and core size, the cell line used, and the subcellular localization of nanoparticles. ...
Toughening Nanoparticle Films via Polymer Infiltration and Confinement
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-06 ,DOI:10.1021/acsami.8b15027
Yijie Jiang, Jyo Lyn Hor, Daeyeon Lee, Kevin T. Turner
Our findings demonstrate that polymer infiltration is a highly effective route for reinforcing nanoparticlepackings while retaining porosity. ...
Metal (Au, Pt) Nanoparticle–Latex Nanocomposites as Probes for Immunochromatographic Test Strips with Enhanced Sensitivity
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-17 ,DOI:10.1021/acsami.8b11745
Yasufumi Matsumura, Yasushi Enomoto, Mari Takahashi, Shinya Maenosono
The lowest detectable concentrations of the influenza A antigen were found to be 6.25 × 10–3 and 2.5 × 10–2 HAU/mL for Au nanoparticle–latex and Pt nanoparticle–latex nanocomposite particles, respectively, whereas it was 4.0 × 10–1 HAU/mL for Au nanoparticles. ...
Role of Surface Chemistry on Nanoparticle Dispersion and Vanadium Ion Crossover in Nafion Nanocomposite Membranes
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-09 ,DOI:10.1021/acsami.8b11297
Allison Jansto, Eric M. Davis
At a nanoparticle loading of 5 wt %, membranes containing unfunctionalized and amine-functionalized SiNPs demonstrated ∼25% reduction in vanadium ion permeability as compared to unmodified Nafion. ...
How Ligands Affect Resistive Switching in Solution-Processed HfO2 Nanoparticle Assemblies
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-29 ,DOI:10.1021/acsami.7b17376
Jiaying Wang, Satyan Choudhary, Jonathan De Roo, Katrien De Keukeleere, Isabel Van Driessche, Alfred J. Crosby, Stephen S. Nonnenmann
Here, we employ a simple flow coating method for the facile deposition of highly ordered HfO2 nanoparticle nanoribbon assemblies. ...
Versatile Platform for Nanoparticle Surface Bioengineering Based on SiO2-Binding Peptide and Proteinaceous Barnase*Barstar Interface
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-05-09 ,DOI:10.1021/acsami.8b01627
Victoria O. Shipunova, Ivan V. Zelepukin, Oleg A. Stremovskiy, Maxim P. Nikitin, Andrew Care, Anwar Sunna, Andrei V. Zvyagin, Sergey M. Deyev
nanoparticle–protein complex. ...
Pd Nanoparticle Film on a Polymer Substrate for Transparent and Flexible Hydrogen Sensors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-14 ,DOI:10.1021/acsami.8b15445
Bo Xie, Peng Mao, Minrui Chen, Zhaoguo Li, Juanjuan Han, Lun Yang, Xiuzhang Wang, Min Han, Jun-Ming Liu, Guanghou Wang
Nanoparticle films are ideal H2-sensing materials that can be coupled with flexible substrates because of their discrete nanogranular structure and unique interparticle electrical responsiveness. ...
Nitrogen and Fluorine Codoped, Colloidal TiO2 Nanoparticle: Tunable Doping, Large Red-Shifted Band Edge, Visible Light Induced Photocatalysis, and Cell Death
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-02 ,DOI:10.1021/acsami.7b14025
Aritra Biswas, Atanu Chakraborty, Nikhil R. Jana
This work shows the potential advantage of anisotropic nanoparticle precursor for tunable doping and colloidal form of N, F codoped TiO2 nanoparticle as a visible light photocatalyst. ...
Roll-to-Roll Processing of Silicon Carbide Nanoparticle-Deposited Carbon Fiber for Multifunctional Composites
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-24 ,DOI:10.1021/acsami.8b03401
Christopher C. Bowland, Ngoc A. Nguyen, Amit K. Naskar
This work demonstrates successful and efficient integration of nanoparticle synthesis into large-scale, structural applications. ...
Nanohybrid of Carbon Quantum Dots/Molybdenum Phosphide Nanoparticle for Efficient Electrochemical Hydrogen Evolution in Alkaline Medium
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-03-09 ,DOI:10.1021/acsami.8b00211
Linjie Zhang, Yanmei Yang, Muhammad Asad Ziaee, Kanglong Lu, Ruihu Wang
In this work, the nanohybrid of carbon quantum dots and molybdenum phosphide nanoparticle (CQDs/MoP) has been firstly demonstrated as an efficient alkaline HER electrocatalyst. ...


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