纳米医学网
首页  |  关于我们  |   加入收藏  |  留言反馈
当前位置:首页 >
2018年生物纳米研究经典报道(五)
来源于:纳米医学网 | 作者: | 发布时间:2017-11-25 | 浏览:312



Robot-Based High-Throughput Engineering of Alcoholic Polymer: Fullerene Nanoparticle Inks for an Eco-Friendly Processing of Organic Solar Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-27 ,DOI:10.1021/acsami.8b03621
Development of high-quality organic nanoparticle inks is a significant scientific challenge for the industrial production of solution-processed organic photovoltaics (OPVs) with eco-friendly processing methods. ...
Optical Control of Nanoparticle Catalysis Influenced by Photoswitch Positioning in Hybrid Peptide Capping Ligands
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-21 ,DOI:10.1021/acsami.8b10582
Here, we present an in-depth analysis of structural factors that modulate peptide-capped nanoparticlecatalytic activity via optically driven structural reconfiguration of the biointerface present at the particle surface. ...
Ligand-Dependent Nanoparticle Assembly and Its Impact on the Printing of Transparent Electrodes
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-02-08 ,DOI:10.1021/acsami.7b18579
Printing such narrow lines with dilute metal nanoparticle inks is challenging because it requires percolation throughout the particle packing. ...
Enhanced Radiation Shielding with Conformal Light-Weight Nanoparticle–Polymer Composite
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-02 ,DOI:10.1021/acsami.8b10600
Given its low cost, light weight, and structure conformability, bismuth nanoparticle–polymer composite will find its use in a wide range of fields related to personal radiation protection. ...
Machine-Learning Identification of the Sensing Descriptors Relevant in Molecular Interactions with Metal Nanoparticle-Decorated Nanotube Field-Effect Transistors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-28 ,DOI:10.1021/acsami.8b15785
Interactions of purine compounds with metal nanoparticle-decorated SWCNTs were corroborated by density functional theory calculations. ...
Engineering of β-Hydroxyl Esters into Elastomer–Nanoparticle Interface toward Malleable, Robust, and Reprocessable Vitrimer Composites
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-12 ,DOI:10.1021/acsami.7b17465
Herein, we demonstrate a simple way to prepare covalently cross-linked yet recyclable and robust elastomeric vitrimer composites by incorporating exchangeable β-hydroxyl ester bonds into the elastomer–nanoparticle interface using epoxy group-functionalized silica (Esilica) as both cross-linker and reinforcement ...
Nanoparticle Immobilization for Controllable Experiments in Liquid-Cell Transmission Electron Microscopy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-22 ,DOI:10.1021/acsami.8b03688
These nucleated particles decorated the parent nanoparticle surface, forming consecutive monolayer assemblies of ∼2 nm diameter nanoparticles, which sinter into the parent particle when the electron beam was shut off. ...
Ligand Density and Linker Length are Critical Factors for Multivalent Nanoparticle–Receptor Interactions
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-20 ,DOI:10.1021/acsami.8b18843
Even though to date, the nanoparticle size and its degree of functionalization are considered to be the major determinants for controlling the uptake efficiency of targeted colloids, these results strongly suggest that the role of the linker length should be carefully taken into consideration for the ...
Suppression of Tumor Energy Supply by Liposomal Nanoparticle-Mediated Inhibition of Aerobic Glycolysis
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-09 ,DOI:10.1021/acsami.7b16685
This report demonstrates the potential utility of the nanoparticle-enabled delivery of an aerobic glycolysis inhibitor as an anticancer therapeutic agent. ...
Blocking Autophagic Flux Enhances Iron Oxide Nanoparticle Photothermal Therapeutic Efficiency in Cancer Treatment
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-09 ,DOI:10.1021/acsami.8b10167
Here, we present a study elaborating the relationships between autophagy and iron oxide nanoparticle(IONP)-mediated photothermal therapy in cancer treatment. ...
Novel Solid Lipid Nanoparticle with Endosomal Escape Function for Oral Delivery of Insulin
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-03-08 ,DOI:10.1021/acsami.8b00507
We herein reported a solid lipid nanoparticle (SLN) platform with a unique feature of endosomal escape for oral protein drug delivery. ...
High-Performance Flexible ZnO Nanorod UV/Gas Dual Sensors Using Ag Nanoparticle Templates
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-05 ,DOI:10.1021/acsami.8b13046
Flexible zinc oxide (ZnO) nanorod (NR) ultraviolet (UV)/gas dual sensors using silver (Ag) nanoparticle(NP) templates were successfully fabricated on a polyimide substrate with nickel electrodes. ...
Programmable Target-Initiated DNAzyme Walker Walking along a Spatially Isolated and Highly Hybridizable Substrate Track on a Nanoparticle Surface
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-11 ,DOI:10.1021/acsami.8b16408
Current nanoscale 3D DNA tracks are typically created by self-assembling thiolated oligonucleotides at gold nanoparticle (AuNP) surfaces via the strong Au–S chemistry. ...
Gold Nanoparticle-Based Photoluminescent Nanoswitch Controlled by Host–Guest Recognition and Enzymatic Hydrolysis for Arginase Activity Assay
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-02-05 ,DOI:10.1021/acsami.7b19513
The fluorescence intensity of 6-aza-2-thiothymine-stabilized gold nanoparticle (ATT-AuNP) is enhanced by l-arginine, owing to the formation of a supramolecular host–guest assembly between the guanidine group of l-arginine and ATT molecules capped on the AuNP surface. ...
Activity, Selectivity, and Durability of Ruthenium Nanoparticle Catalysts for Ammonia Synthesis by Reactive Molecular Dynamics Simulation: The Size Effect
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-30 ,DOI:10.1021/acsami.8b05070
We report a molecular dynamics (MD) simulation employing the reactive force field (ReaxFF), developed from various first-principles calculations in this study, on ammonia (NH3) synthesis from nitrogen (N2) and hydrogen (H2) gases over Ru nanoparticle (NP) catalysts. ...
Solution-Phase Synthesis of Platinum Nanoparticle-Decorated Metal-Organic Framework Hybrid Nanomaterials as Biomimetic Nanoenzymes for Biosensing Applications
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-09 ,DOI:10.1021/acsami.8b04737
Herein, a facile and simple method for the preparation of platinum nanoparticle (PtNP)-decorated two-dimensional metal-organic framework (MOF) nanocomposites was developed. ...
Facile Method and Novel Dielectric Material Using a Nanoparticle-Doped Thermoplastic Elastomer Composite Fabric for Triboelectric Nanogenerator Applications
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-05 ,DOI:10.1021/acsami.8b02133
Herein, a novel nanoparticle (NP)-doped TPE composite fabric-based TENG (TF-TENG) has been developed, which operates based on the NP-doped TPE composite fabric using a facile coating method. ...
Synthesizing Pickering Nanoemulsions by Vapor Condensation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-18 ,DOI:10.1021/acsami.8b06467
Herein, we show that Pickering nanoemulsions can be obtained in a single step even at very low nanoparticle loadings (0.2 wt %) by condensing water vapor on a nanoparticle-infused subcooled oil that spreads on water. ...
Low-Cost Nanostructures from Nanoparticle-Assisted Large-Scale Lithography Significantly Enhance Thermal Energy Transport across Solid Interfaces
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-26 ,DOI:10.1021/acsami.8b08180
In this study, however, we demonstrate significant thermal conductance enhancements across metal–semiconductor interfaces by as much as 90% higher than that of the planar interfaces using engineered nanostructures fabricated by Au nanoparticle (NP)-assisted lithography, where self-assembled Au NPs are ...
Spray-Processed Composites with High Conductivity and Elasticity
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-11 ,DOI:10.1021/acsami.8b00068
High nanoparticle loading was achieved by introducing silver nanoparticles into the fiber spinning solution. The presence of the silver nanoparticles facilitates improved uptake of silver nanoparticleprecursor in subsequent processing steps. ...
Design and Development of Graphene Oxide Nanoparticle/Chitosan Hybrids Showing pH-Sensitive Surface Charge-Reversible Ability for Efficient Intracellular Doxorubicin Delivery
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-02-07 ,DOI:10.1021/acsami.7b16910
A novel graphene oxide nanoparticle (GON)-based drug delivery system containing GONs as carriers of anticancer drugs and chitosan/dimethylmaleic anhydride-modified chitosan (CS/CS-DMMA) as surface charge-reversible shells is fabricated via the classic self-assembly of the deprotonated carboxyl of GONs ...
Sinter-Resistant and Highly Active Sub-5 nm Bimetallic Au–Cu Nanoparticle Catalysts Encapsulated in Silica for High-Temperature Carbon Monoxide Oxidation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-24 ,DOI:10.1021/acsami.7b19299
X-ray diffraction and X-ray photoelectron spectroscopy characterization confirmed the presence of Au–Cu nanocomposites in the catalyst, while transmission electron microscopy characterization revealed the core–shell structure of the catalyst with the presence of sub-5 nm Au–Cu nanoparticle cores inside ...
Curved TiO2 Nanoparticles in Water: Short (Chemical) and Long (Physical) Range Interfacial Effects
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-09 ,DOI:10.1021/acsami.8b08172
basicity/acidity of the nanoparticle in water, the interface effect on crystallinity, surface energy, and electronic properties, such as the band gap and work function. ...
Deep Insight into PEGylation of Bioadhesive Chitosan Nanoparticles: Sensitivity Study for the Key Parameters Through Artificial Neural Network Model
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-26 ,DOI:10.1021/acsami.8b11178
Nanoparticle groups that had higher zeta potentials promoted adhesion of HEK293-T cells to nanoparticle-coated surfaces in cell culture medium, which was predicted through ANN model prior to experiments. ...
Lipid Stabilized Solid Drug Nanoparticles for Targeted Chemotherapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-23 ,DOI:10.1021/acsami.8b07024
Nanoparticle-based chemotherapeutics have gained widespread interest in medicine due to their tunable pharmacokinetics and pharmacodynamics. Various drug delivery vehicles have been developed including polymer, liposome nanoparticles, and some of them have already made clinical impacts. ...
Firefly-like Water Splitting Cells Based on FRET Phenomena with Ultrahigh Performance over 12%
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-26 ,DOI:10.1021/acsami.7b18003
A firefly-like chemiluminescence reaction was utilized in a ZrO2 nanoparticle matrix of water splitting cells, where the chlorophyll of Lantana camara was used as the major photosensitizer to excite electrons to the conduction band of ZrO2. ...
Nanoscale Generation of Robust Solid Films from Liquid-Dispersed Nanoparticles via in Situ Atomic Force Microscopy: Growth Kinetics and Nanomechanical Properties
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-11-09 ,DOI:10.1021/acsami.8b16680
Here, we present the results of an in situ study of the kinetics of nanoparticle tribofilm growth using colloidal-probe atomic force microscopy (AFM). ...
Smaller CpG-Conjugated Gold Nanoconstructs Achieve Higher Targeting Specificity of Immune Activation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-21 ,DOI:10.1021/acsami.8b06633
Three different gold nanoparticle cores (13 nm spheres, 50 nm spheres, and 40 nm stars) with the same CpG surface density were investigated for toll-like receptor 9 activation. ...
Multifunctional Yolk–Shell Mesoporous Silica Obtained via Selectively Etching the Shell: A Therapeutic Nanoplatform for Cancer Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-11 ,DOI:10.1021/acsami.8b08574
Herein, we fabricated a new yolk–shell-structured mesoporous silica nanoparticle (YMSN) with multifunctionalities of fluorescence imaging, photothermal therapy (PTT), and drug delivery by using a fluorescein isothiocyanate-doped silica nanoparticle partially covered by patchy gold as the core. ...
Plasmonic-Enhanced Luminescence Characteristics of Microscale Phosphor Layers on a ZnO Nanorod-Arrayed Glass Substrate
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-17 ,DOI:10.1021/acsami.8b13767
The system comprised a microscale yellow phosphor layer that is applied by simple printing onto an Au nanoparticle-dispersed ZnO nanorod array. ...
Loading across the Periodic Table: Introducing 14 Different Metal Ions To Enhance Metal–Organic Framework Performance
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-04 ,DOI:10.1021/acsami.8b08496
Li/Mg/Ca-loaded MIL-121 and Ag nanoparticle-loaded MIL-121 exhibit enhanced H2 and CO2 adsorption; Ag nanoparticle-loaded MIL-121 also demonstrates remarkable catalytic activity in the reduction of 4-nitrophenol. ...
Resistance to Nano-Based Antifungals Is Mediated by Biomolecule Coronas
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-18 ,DOI:10.1021/acsami.8b12175
We show that nanoparticle–spore complex formation was enhanced by the small nanoparticle size rather than the material, shape or charge, and could not be prevented by steric surface modifications. ...
Impact of Morphology on Iron Oxide Nanoparticles-Induced Inflammasome Activation in Macrophages
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-11-21 ,DOI:10.1021/acsami.8b17474
In this report, we have synthesized four morphologically distinct IONPs having the same aspect ratio and similar surface charge, thus offering an ideal system to assess the impact of morphology on nanoparticle-elicited biological effect. ...
Composite Multifunctional Micromotors from Droplet Microfluidics
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-26 ,DOI:10.1021/acsami.8b11976
Here, we present a capillary microfluidic system with dual inner injections for one-step generation of composite structured polymer micromotors with two distinct cores of platinum (Pt) nanoparticle-integrated and iron oxide (Fe3O4) nanoparticle-dispersed hydrogels. ...
Overcoming Chemoresistance in Cancer via Combined MicroRNA Therapeutics with Anticancer Drugs Using Multifunctional Magnetic Core–Shell Nanoparticles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-02 ,DOI:10.1021/acsami.8b09086
In this study, we report the use of a multifunctional magnetic core–shell nanoparticle (MCNP), composed of a highly magnetic zinc-doped iron oxide (ZnFe2O4) core nanoparticle and a biocompatible mesoporous silica (mSi) shell, for the simultaneous delivery of let-7a microRNA (miRNA) and anticancer drugs ...
Magnesium-Stabilized Multifunctional DNA Nanoparticles for Tumor-Targeted and pH-Responsive Drug Delivery
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-30 ,DOI:10.1021/acsami.8b01932
The resultant DNA nanoparticle exhibits a high biostability, making it a safe and ideal nanomaterial for in vivo application. ...
Highly Sensitive and Reproducible SERS Sensor for Biological pH Detection Based on a Uniform Gold Nanorod Array Platform
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-25 ,DOI:10.1021/acsami.7b19347
Conventional research on surface-enhanced Raman scattering (SERS)-based pH sensors often depends on nanoparticle aggregation, whereas the variability in nanoparticle aggregation gives rise to poor repeatability in the SERS signal. ...
Palladium Nanoparticle-Enabled Ultrathick Tribofilm with Unique Composition
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-06 ,DOI:10.1021/acsami.8b11213
There is a consensus that savings of 1.0–1.4% of a country’s gross domestic product may be achieved through lubrication R&D. Recent studies have shown great potential for using surface-functionalized nanoparticles (NPs) as lubricant additives to enhance lubricating performance. NPs were reported with ability of producing a low-friction antiwear tribofilm, usually 20–200 nm in thickness, on the contact surface. In contrast, this study reports an unexpected 10 times thicker (2–3 μm) tribofilm formed by dodecanethiol-modified palladium NPs (core size: 2–4 nm) in boundary lubrication of a steel–cast iron contact. Adding 0.5–1.0 wt % such NPs to a lubricating oil resulted in significant reductions in friction and wear by up to 40 and 97%, respectively. Further investigation suggested that the PdNP core primarily was responsible for the improvement in both friction and wear, whereas the thiolate ligand only contributed to the wear protection but had little impact on the friction behavior. In addition, unlike most previously reported tribofilms that contain a substantial amount of metal oxides, this PdNP-induced tribofilm is clearly dominated by Pd/S compounds, as revealed by nanostructural examination and chemical analysis. Such a ultrathick tribofilm with unique composition is believed to be responsible for the superior lubricating behavior. ...
Spontaneous Redox Approach to the Self-Assembly Synthesis of Au/CeO2 Plasmonic Photocatalysts with Rich Oxygen Vacancies for Selective Photocatalytic Conversion of Alcohols
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-10 ,DOI:10.1021/acsami.8b10705
The results demonstrate that the as-synthesized Au/CeO2 composites exhibit spherical shape morphologies with porous structures, composed of Au nanoparticle (∼10 nm) cores and CeO2 nanoparticle shells with abundant oxygen vacancies. ...
Laser Sintering of Liquid Metal Nanoparticles for Scalable Manufacturing of Soft and Flexible Electronics
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-09 ,DOI:10.1021/acsami.8b08722
The effects of laser fluence, nanoparticle size, film thickness, and substrate material on resistance of the sintered films are evaluated. ...
In Vivo Imaging Tracking and Immune Responses to Nanovaccines Involving Combined Antigen Nanoparticles with a Programmed Delivery
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-25 ,DOI:10.1021/acsami.8b04867
Compared with a single nanoparticle formulation, the combined nanovaccine exactly elicited a stronger antigen-specific immune response. ...
Bacteria-Targeting Nanoparticles with Microenvironment-Responsive Antibiotic Release To Eliminate Intracellular Staphylococcus aureus and Associated Infection
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-19 ,DOI:10.1021/acsami.7b15678
We herein report a unique intracellular antibiotic delivery nanoparticle, which is composed of (i) a mesoporous silica nanoparticle (MSN) core loaded with gentamicin, (ii) an infected microenvironment (bacterial toxin)-responsive lipid bilayer surface shell, and (iii) bacteria-targeting peptide ubiquicidin ...
Black Phosphorus Stabilizing Na2Ti3O7/C Each Other with an Improved Electrochemical Property for Sodium-Ion Storage
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-19 ,DOI:10.1021/acsami.8b14971
Under the protection of argon (Ar) atmosphere, the direct high-energy mechanical milling of the BP nanoparticle and NTO/C results in the formation of NTO/C–BP hybrids. ...
Palladium Supported on an Amphiphilic Triazine–Urea-Functionalized Porous Organic Polymer as a Highly Efficient Electrocatalyst for Electrochemical Sensing of Rutin in Human Plasma
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-01 ,DOI:10.1021/acsami.8b00579
Metal nanoparticle-containing porous organic polymers have gained great interest in chemical and pharmaceutical applications owing to their high reactivity and good recyclability. ...
Surface Properties of Laser-Treated Molybdenum Disulfide Nanosheets for Optoelectronic Applications
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-05-17 ,DOI:10.1021/acsami.8b04717
The extent of nanoparticle formation and nanosheet oxidation in each of these regimes is found to be dependent on the number of layers and laser treatment time. ...
Simple and Sensitive Quantification of MicroRNAs via PS@Au Microspheres-Based DNA Probes and DSN-Assisted Signal Amplification Platform
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-18 ,DOI:10.1021/acsami.7b16733
This paper focused on a kind of gold-nanoparticle-coated polystyrene microbeads (PS@Au microspheres)-based DNA probe as miRNA capture and duplex-specific nuclease (DSN) signal amplification platform based on an RGB value readout for detection of miRNAs. ...
Recyclable Amphiphilic Metal Nanoparticle Colloid Enabled Atmospheric Oxidation of Alcohols
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-28 ,DOI:10.1021/acsami.8b12989
Developing amphiphilic colloid catalysts is essentially important for realizing environmentally benign biphasic catalysis under atmospheric conditions. Herein, a linear structured plant polyphenol was employed as an amphiphilic stabilizer for preparing a series of amphiphilic Pd nanoparticles (PdNPs) colloids. For the as-prepared PdNPs colloids, the phenolic hydroxyls of plant polyphenols were responsible for the stabilization of PdNPs, whereas the rigid aromatic scaffold of plant polyphenols effectively suppressed the PdNPs from aggregation by providing a high steric effect. Thanks to the coexistence of hydrophilic phenolic hydroxyls and hydrophobic aromatic rings, the plant polyphenols induced tunable amphiphilic properties into the PdNPs, allowing an easier wetting of PdNPs with the substrate molecules. By tuning the content of plant polyphenols in the colloid, the particle size (3.17–4.73 nm) and the dispersity of the PdNPs were facilely controlled. When applied for atmospheric oxidation of insoluble alcohols in water by air, the amphiphilic PdNPs preferentially absorbed the alcohol substrates to create a relatively high-substrate-concentration microenvironment, which improved the mass transfer in the biphasic catalysis, allowing the proceeding of low-temperature (50 °C) atmospheric oxidation of diverse alcohols with high catalytic conversion, including aliphatic alcohols, cyclic aliphatic alcohols, and aromatic alcohols. Furthermore, the amphiphilic PdNPs colloid also exhibited excellent reusability with a conversion yield high up to 97.96% in the fifth cycle. In contrast, the control catalysts of poly(vinylpyrrolidone)- and poly(ethylene glycol)-stabilized PdNPs were completely inactivated in the fifth cycle. As a consequence, our findings provided a new route for developing an environmentally benign aqueous colloid catalyst that is both highly active and recyclable for mild biphasic oxidation reaction systems. ...
Sulfonato-β-Cyclodextrin Mediated Supramolecular Nanoparticle for Controlled Release of Berberine
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-17 ,DOI:10.1021/acsami.8b08651
A kind of supramolecular assemblies was constructed from two water-soluble and biocompatible saccharides, sulfonato-β-cyclodextrin (SCD) and chitosan, and characterized by dynamic light scattering (DLS), UV–vis, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The results showed that such nanoparticles presented good stability and controlled loading/release property, which enabled them as good drug carrier for berberine chloride (BE), a representative drug from traditional Chinese herbs. That is, the nanoparticles can load BE with high stability in a low-pH environment like that of the stomach but released BE when moved to a high-pH environment like that of the intestine. ...
Bio-inspired Carbon Hole Transporting Layer Derived from Aloe Vera Plant for Cost-Effective Fully Printable Mesoscopic Carbon Perovskite Solar Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-07 ,DOI:10.1021/acsami.8b08383
The air and moisture stability >1000 h at >45% relative humidity (RH) for cross-linked AV-C nanoparticle-based PSCs. This stability is very high compared to conventional spiro-MeOTAD HTM-based PSCs. ...
Surface-Functionalized Silicon Nanoparticles as Anode Material for Lithium-Ion Battery
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-11 ,DOI:10.1021/acsami.8b17729
An epoxy group was successfully attached to the surface of silicon nanoparticle (SiNPs) via a silanization reaction between silanol-enriched SiNPs and functional silanes. ...
Tailored Macroporous Hydrogels with Nanoparticles Display Enhanced and Tunable Catalytic Activity
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-15 ,DOI:10.1021/acsami.8b06560
The fabrication process is scalable, and is compatible with broad choices of polymer blend, gel, and nanoparticle chemistries. ...
Large-Scale Synthesis of Colloidal Si Nanocrystals and Their Helium Plasma Processing into Spin-On, Carbon-Free Nanocrystalline Si Films
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-06 ,DOI:10.1021/acsami.8b03771
We further show that the reactive ion etching rate in these films is 1.87 times faster than that for single-crystalline Si, consistent with a simple geometric argument that accounts for the nanoscale roughness caused by the nanoparticle shape. ...
HDL-AuNPs-BMS Nanoparticle Conjugates as Molecularly Targeted Therapy for Leukemia
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-18 ,DOI:10.1021/acsami.8b01696
Gold nanoparticles (AuNPs) with adsorbed high-density lipoprotein (HDL) have been utilized to deliver oligonucleotides, yet HDL-AuNPs functionalized with small-molecule inhibitors have not been systematically explored. Here, we report an AuNP-based therapeutic system (HDL-AuNPs-BMS) for acute myeloid leukemia (AML) by delivering BMS309403 (BMS), a small molecule that selectively inhibits AML-promoting factor fatty acid-binding protein 4. To synthesize HDL-AuNPs-BMS, we use AuNP as a template to control conjugate size ensuring a spherical shape to engineer HDL-like nanoparticles containing BMS. The zeta potential and size of the HDL-AuNPs obtained from transmission electron microscopy demonstrate that the HDL-AuNPs-BMS are electrostatically stable and 25 nm in diameter. Functionally, compared to free drug, HDL-AuNPs-BMS conjugates are more readily internalized by AML cells and have more pronounced effects on downregulation of DNA methyltransferase 1 (DNMT1), induction of DNA hypomethylation, and restoration of epigenetically silenced tumor suppressor p15INK4B coupled with AML growth arrest. Importantly, systemic administration of HDL-AuNPs-BMS conjugates into AML-bearing mice inhibits DNMT1-dependent DNA methylation, induces AML cell differentiation, and diminishes AML disease progression without obvious side effects. In summary, these data, for the first time, demonstrate HDL-AuNPs as an effective delivery platform with great potential to attach distinct inhibitors and HDL-AuNPs-BMS conjugates as a promising therapeutic platform to treat leukemia. ...
Endogenous Stimuli-Responsive Nucleus-Targeted Nanocarrier for Intracellular mRNA Imaging and Drug Delivery
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-26 ,DOI:10.1021/acsami.8b16345
This nanocarrier (AuNP-mRS-DSs) is composed of three parts: (i) gold nanoparticle (AuNP), for loading DNA and quenching fluorescence; (ii) mRNA recognition sequence (mRS) modified on the surface of gold nanoparticle by gold-thiol bond, for the specific recognition of MRP1 mRNA; (iii) detachable subunit ...
Intestinal Mucin Induces More Endocytosis but Less Transcytosis of Nanoparticles across Enterocytes by Triggering Nanoclustering and Strengthening the Retrograde Pathway
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-02 ,DOI:10.1021/acsami.7b19153
Mucin was found to adhere to the nanoparticle surface to form a corona structure and induce the clustering of PGNPs by joining particles together, demonstrating the interaction between mucin and PGNPs. ...
Pulverization Control by Confining Fe3O4 Nanoparticles Individually into Macropores of Hollow Carbon Spheres for High-Performance Li-Ion Batteries
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-12 ,DOI:10.1021/acsami.7b16530
This can be due to the in situ embedment of one Fe3O4 nanoparticle into one macropore individually. ...
DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-11 ,DOI:10.1021/acsami.8b17846
Advances in nanoparticle design have led to the development of nanoparticulate systems that can sense intracellular molecules, alter cellular processes, and release drugs to specific targets in vitro. ...
Surface-Bound Gradient Deposition of Protein Nanoparticles for Cell Motility Studies
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-23 ,DOI:10.1021/acsami.8b06821
Fully controllable patterns with specific periodicities consisting of stripes with different widths and distinct nanoparticle concentration as well as gradients can be produced over large areas (∼10 cm2) in a fast (up to 10 mm2/min), reproducible, and cost-effective manner using an operational protocol ...
Thermal, Waterproof, Breathable, and Antibacterial Cloth with a Nanoporous Structure
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-04 ,DOI:10.1021/acsami.7b16422
Herein, we present a multifunctional cloth starting from a cotton fabric, for which one side is modified to be superhydrophobic by introducing a silica nanoparticle/polydimethylsiloxane (PDMS) layer, while the other side is coated with a nanoporous cellulose acetate layer followed by depositing a thin ...
Calcium Phosphate Nanoparticles as Intrinsic Inorganic Antimicrobials: The Antibacterial Effect
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-28 ,DOI:10.1021/acsami.8b12784
It is used in a number of industries, including the biomedical, but its intrinsic antibacterial activity in the nanoparticle form has not been sufficiently explored to date. ...
Heterogeneous Integration of Three-Primary-Color Photoluminescent Nanoparticle Arrays with Defined Interfaces
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-24 ,DOI:10.1021/acsami.8b16884
Minimized photoluminescent devices require both high-density fluorescent arrays and minimal cross-talk between neighboring pixels on the limited area. However, the challenges to achieve the overall integration of nanomaterial-based devices hinder the development of microscale full-color displays, including micro/nanoarray density, orientation control, multimaterial interface morphology, and uniform colors. Here, we report a heterogeneous integration approach to control the orientation, combination, and density of fluorescent micro/nanoarrays on flexible substrates. By controlling the defined interface and critical shrinkage width of liquid bridges, the width of three-primary-color micro/nanolines reached 100 nm. The interval between two parallel luminous lines is down to 40 μm, and the optical cross-talk effect is remarkably reduced. This work provides a facile approach to prepare high-performance micro-photoluminescent and imaging arrays for next-generation flexible display and lighting technology. ...
Nanoparticle-Based Proximity Ligation Assay for Ultrasensitive, Quantitative Detection of Protein Biomarkers
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-11 ,DOI:10.1021/acsami.8b01377
Proximity ligation assay (PLA) achieves extremely low limits of detection but requires the synthesis of antibody–DNA conjugates recognizing multiple target epitopes with appropriate proximity. In this work, we introduce a more generally applicable method by replacing antibody–DNA conjugates with nanoparticles which create ultradetectable PCR templates by capturing biotinylated oligonucleotides and catalyzing ligation. A competitive PCR readout was used to make the assay quantitative. We have demonstrated that NP-PLA can detect and quantitate human chorionic gonadotropin (hCG) levels as low as 2.6 fM (∼0.1 pg/mL), nearly 1000 times more sensitive than the current state of the art ELISA. ...
Amorphous Calcium Carbonate Constructed from Nanoparticle Aggregates with Unprecedented Surface Area and Mesoporosity
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-13 ,DOI:10.1021/acsami.8b03939
Amorphous calcium carbonate (ACC), with the highest reported specific surface area of all current forms of calcium carbonate (over 350 m2 g–1), was synthesized using a surfactant-free, one-pot method. Electron microscopy, helium pycnometry, and nitrogen sorption analysis revealed that this highly mesoporous ACC, with a pore volume of ∼0.86 cm3 g–1 and a pore-size distribution centered at 8–9 nm, is constructed from aggregated ACC nanoparticles with an estimated average diameter of 7.3 nm. The porous ACC remained amorphous and retained its high porosity for over 3 weeks under semi-air-tight storage conditions. Powder X-ray diffraction, large-angle X-ray scattering, infrared spectroscopy, and electron diffraction exposed that the porous ACC did not resemble any of the known CaCO3 structures. The atomic order of porous ACC diminished at interatomic distances over 8 Å. Porous ACC was evaluated as a potential drug carrier of poorly soluble substances in vitro. Itraconazole and celecoxib remained stable in their amorphous forms within the pores of the material. Drug release rates were significantly enhanced for both drugs (up to 65 times the dissolution rates for the crystalline forms), and supersaturation release of celecoxib was also demonstrated. Citric acid was used to enhance the stability of the ACC nanoparticles within the aggregates, which increased the surface area of the material to over 600 m2 g–1. This porous ACC has potential for use in various applications where surface area is important, including adsorption, catalysis, medication, and bone regeneration. ...
Tunable Resonance Coupling in Single Si Nanoparticle–Monolayer WS2 Structures
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-05-03 ,DOI:10.1021/acsami.7b17112
Two-dimensional semiconducting transition metal dichalcogenides (TMDCs) are extremely attractive materials for optoelectronic applications in the visible and near-infrared range. Coupling these materials to optical nanocavities enables advanced quantum optics and nanophotonic devices. Here, we address the issue of resonance coupling in hybrid exciton–polariton structures based on single Si nanoparticles (NPs) coupled to monolayer (1L)-WS2. We predict a strong coupling regime with a Rabi splitting energy exceeding 110 meV for a Si NP covered by 1L-WS2 at the magnetic optical Mie resonance because of the symmetry of the mode. Further, we achieve a large enhancement in the Rabi splitting energy up to 208 meV by changing the surrounding dielectric material from air to water. The prediction is based on the experimental estimation of TMDC dipole moment variation obtained from the measured photoluminescence spectra of 1L-WS2 in different solvents. An ability of such a system to tune the resonance coupling is realized experimentally for optically resonant spherical Si NPs placed on 1L-WS2. The Rabi splitting energy obtained for this scenario increases from 49.6 to 86.6 meV after replacing air by water. Our findings pave the way to develop high-efficiency optoelectronic, nanophotonic, and quantum optical devices. ...
A Novel Graphdiyne-Based Catalyst for Effective Hydrogenation Reaction
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-02-22 ,DOI:10.1021/acsami.8b00566
Our results indicated that graphdiyne is a promising substrate for constructing metal nanoparticle-based heterogeneous catalysts, especially for those requiring strong interactions between metal nanoparticles and reactants. ...
Photonic Curing of Low-Cost Aqueous Silver Flake Inks for Printed Conductors with Increased Yield
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-18 ,DOI:10.1021/acsami.8b04157
The resistivity of printed patterns after an optimized photocuring regime matched those reported for typical nanoparticle inks; on the order of 100 μΩ cm depending on substrate and geometry. ...
Monodispersed Ag Nanoparticle in Layered Double Hydroxides as Matrix for Laser Desorption/Ionization Mass Spectrometry
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-13 ,DOI:10.1021/acsami.8b17051
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) in the low-molecular-weight (LMW) range is a long-standing challenge because of the fragments from the matrix and the heterogeneity of the matrix-analyte crystals. In this work, a homogeneous film with the monodispersed Ag nanoparticles (Ag NPs) in the confined interlayer of layered double hydroxides (LDHs) has been achieved. The Ag NPs with advantageous optical absorption could realize the energy capture and transfer process, and LDHs with abundant hydroxyl groups are beneficial for the deprotonated reaction. Therefore, the as-prepared film exhibited interference-free deprotonated signals in negative-ion mode with high ionization efficiency. The uniform matrix-analyte spots were constructed through the homogeneous assembly process, contributing to the high reproducibility for both the liquid and gaseous samples. Good linearities were successfully realized in the range from 0.1 μM to 1.0 mM for glucose with the relative standard deviation (RSD) of 3.8%, and 0.2–2.0 mM with the average RSD of 4.5% for psoralen samples, respectively. It is believed that the proposed matrix could exhibit competitive advantages for MALDI detection in the LMW region, which may provide new insight into development for MALDI mass detection. ...
Hydrogen-Bonded Tannic Acid-Based Anticancer Nanoparticle for Enhancement of Oral Chemotherapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-11-29 ,DOI:10.1021/acsami.8b18979
Oral chemotherapy has been emerging as a hopeful therapeutic regimen for the treatment of various cancers because of its high safety and convenience, lower costs, and high patient compliance. Currently, nanoparticulate drug delivery systems (NDDS) exhibit many unique advantages in mediating oral drug delivery; however, many anticancer drugs that were susceptible in hostile gastrointestinal (GI) environment showed poor permeability across intestinal epithelium, and most materials used as drug carriers are nonactive excipients and displayed no therapeutically relevant function, which leads to low oral bioavailability and therapeutic efficacy of anticancer drugs (e.g., paclitaxel). Inspired by these, in this study, paclitaxel (PTX) was used as a model drug, depending on intermolecular hydrogen-bonded interactions, PTX-loaded tannic acid/poly(N-vinylpyrrolidone) nanoparticles (PTX-NP) were produced by a flash nanoprecipitation (FNP) process. The optimized PTX-NP showed an average diameter of 54 nm with a drug encapsulation efficiency of 80% and loading capacity of 14.5%. Molecular dynamics simulations were carried out to illuminate the assembling mechanism of hydrogen-bonded PTX-NP. In vitro and in vivo results confirmed that PTX-NP showed pH-dependent intestinal site-specific drug release, P-gp inhibitory function by tannic acid (TA), prolonged intestinal retention, and improved trans-epithelial transport properties. Oral administration of PTX-NP generated a high oral delivery efficiency and relative oral bioavailability of 25.6% in rats, and further displayed a significant tumor-inhibition effect in a xenograft breast tumor model. These findings confirmed that our PTX-NP might be a promising oral drug formulation for chemotherapy. ...
Selective Killing of Pathogenic Bacteria by Antimicrobial Silver Nanoparticle—Cell Wall Binding Domain Conjugates
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-16 ,DOI:10.1021/acsami.8b00181
Broad-spectrum antibiotics indiscriminately kill bacteria, removing nonpathogenic microorganisms and leading to evolution of antibiotic resistant strains. Specific antimicrobials that could selectively kill pathogenic bacteria without targeting other bacteria in the natural microbial community or microbiome may be able to address this concern. In this work, we demonstrate that silver nanoparticles, suitably conjugated to a selective cell wall binding domain (CBD), can efficiently target and selectively kill bacteria. As a relevant example, CBDBA from Bacillus anthracis selectively bound to B. anthracis in a mixture with Bacillus subtilis, as well in a mixture with Staphylococcus aureus. This new biologically-assisted hybrid strategy, therefore, has the potential to provide selective decontamination of pathogenic bacteria with minimal impact on normal microflora. ...
One-Pot Synthesis of Gel Glass Embedded with Luminescent Silicon Nanoparticles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-31 ,DOI:10.1021/acsami.8b17604
In this work, we show that luminescent silicon (Si) nanoparticle (NP)- embedded silicate gel glasses can be developed under near-ambient conditions by a remarkably simple, one-pot strategy, without using any sophisticated instrumentation or technique. ...
Successive Interfacial Reaction-Directed Synthesis of CeO2@Au@CeO2-MnO2 Environmental Catalyst with Sandwich Hollow Structure
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-03-27 ,DOI:10.1021/acsami.7b18371
Noble metal nanoparticle-based catalysts are widely used for the removal of hazardous materials. During the catalytic reactions, it is of particular importance for developing novel strategies to avoid the leaching or sintering of noble metal nanoparticles. ...
Wavelength-Selective Three-Dimensional Thermal Emitters via Imprint Lithography and Conformal Metallization
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-02-23 ,DOI:10.1021/acsami.7b16902
Well-defined double-layer titanium dioxide (TiO2) woodpile structures are fabricated using a layer-by-layer soft-imprint method with TiO2 nanoparticle ink dispersions, and the structures are subsequently coated with high purity, conformal gold films via reactive deposition from supercritical carbon dioxide ...
Effect of Surface Chemistry and Associated Protein Corona on the Long-Term Biodegradation of Iron Oxide Nanoparticles In Vivo
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-23 ,DOI:10.1021/acsami.7b18648
The protein corona formed on the surface of a nanoparticle in a biological medium determines its behavior in vivo. Herein, iron oxide nanoparticles containing the same core and shell, but bearing two different surface coatings, either glucose or poly(ethylene glycol), were evaluated. ...
Retraction of "Dual-Responsive Polymer Coated Superparamagnetic Nanoparticle for Targeted Drug Delivery and Hyperthermia Treatment".
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-06 ,DOI:10.1021/acsami.8b15806


Flexible and Broad-Spectral Hybrid Optical Modulation Transistor Based on a Polymer–Silver Nanoparticle Blend
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-25 ,DOI:10.1021/acsami.8b06307
The light-matter interplay on a soft substrate is critically important for novel optoelectronic applications such as soft robotics, human–machine interfaces, and wearable devices. Here, we for the first time report a flexible and efficiency–enhanced hybrid optical modulation transistor (h-OMT) in the ultraviolet–infrared spectral range by blending a polymer with silver nanoparticles (AgNPs). The h-OMT device exhibits a unipolar transport and an ultrahigh on-off ratio of ∼4.8 × 106 in a small voltage range of ∼2 V. Using charge modulation reflection spectroscopy, we demonstrate that the h-OMT device shows a broad-spectral response from 400 to 2000 nm and maximum optical modulation of ∼15% at λ = 785 nm, 6-fold higher magnitude than that of the device without AgNPs. Furthermore, the incorporation of AgNPs enhances the extinction ratio by 4-fold magnitude without any complex geometry designs. We find that the performance improvement relies on the AgNP-induced electron trap states and electrochemical dopings in the polymer. Importantly, the device exhibits pronounced mechanical flexibility, and the optical modulation is kept down to a bending radius of 0.5 mm. Our data provide the possibility of organic materials for constructing novel optoelectronic systems in the future. ...
Photoinduced Enhanced Raman from Lithium Niobate on Insulator Template
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-27 ,DOI:10.1021/acsami.8b10076
Photoinduced enhanced Raman spectroscopy from a lithium niobate on insulator (LNOI)–silver nanoparticle template is demonstrated both by irradiating the template with 254 nm ultraviolet (UV) light before adding an analyte and before placing the substrate in the Raman system (substrate irradiation) and ...
Microfluidic-Assisted Fabrication of Clay Microgels for Cell-Free Protein Synthesis
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-23 ,DOI:10.1021/acsami.8b09324
As an advantageous platform for CFPS, a modular manner to prepare clay microgels with rationally designed functions is demonstrated: (i) gene/clay microgels enhance protein expression, (ii) gene/clay/magnetic nanoparticle microgels enable a repeated protein production system, and (iii) gene/clay microgels ...
Highly Efficient Separation of Glycoprotein by Dual-Functional Magnetic Metal–Organic Framework with Hydrophilicity and Boronic Acid Affinity
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-10 ,DOI:10.1021/acsami.8b07671
In this work, a novel dual-functionalized magnetic metal–organic frameworks nanoparticle for selective enrichment of glycoproteins was synthesized for the first time. ...
Strontium-Doped Bioactive Glass Nanoparticles in Osteogenic Commitment
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-28 ,DOI:10.1021/acsami.8b06154
Our results demonstrate that the nanoparticle dissolution products encouraged the osteogenic differentiation of human adipose stem cells as it favored the expression of key genes and proteins associated with osteogenic lineage. ...
Morphological Behavior of Printed Silver Electrodes with Protective Self-Assembled Monolayers for Electrochemical Migration
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-26 ,DOI:10.1021/acsami.8b02996
We evaluated the electrochemical behaviors and reliability of printed silver (Ag) electrodes prepared from nanoparticle inks with the use of protective self-assembled monolayers (SAMs) under electronic bias conditions. ...
Polydopamine-Derivated Hierarchical Nanoplatforms for Efficient Dual-Modal Imaging-Guided Combination in Vivo Cancer Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-06 ,DOI:10.1021/acsami.8b02973
The high processability of PDA as nanotemplates and surface coating layers as well as its natural affinity to metals facilitated the sandwich of a compact iron oxide nanoparticle layer into the PDA matrix, realizing enhanced near-infrared (NIR) photothermal conversion and strong superparamagnetic responsiveness ...
Optical Properties of Reconfigurable Polymer/Silver Nanoprism Hybrids: Tunable Color and Infrared Scattering Contrast
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-03-02 ,DOI:10.1021/acsami.7b16934
to characterize the hybrids and show that the loading density of the silver nanoprisms in the polymer and the size of the nanoprisms are both factors that can be used to tailor the optical response of the composites, extending the range of colors beyond that previously reported with PNIPAM/plasmonic nanoparticle ...
CuAg@Ag Core–Shell Nanostructure Encapsulated by N-Doped Graphene as a High-Performance Catalyst for Oxygen Reduction Reaction
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-25 ,DOI:10.1021/acsami.7b16294
Herein, we reported a well-defined nanostructured catalyst of highly dispersed CuAg@Ag core–shell nanoparticle (NP)-encapsulated nitrogen-doped graphene nanosheets (CuAg@Ag/N-GNS) exhibiting a superior catalytic activity toward ORR in alkaline medium. ...
Glycan-Imprinted Magnetic Nanoparticle-Based SELEX for Efficient Screening of Glycoprotein-Binding Aptamers
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-11-13 ,DOI:10.1021/acsami.8b14441
Nucleic acid aptamers, as useful alternatives of antibodies, have found a large range of promising applications such as affinity separation and bioassays. The screening of aptamers is critical for their applications. Aptamers are often screened by an in vitro methodology called SELEX (systematic evolution of ligands by exponential enrichment). Although numerous SELEX methods have been established to facilitate the selection, new efficient selection methods are still much needed. Molecularly imprinted polymers, which are antibody alternatives at the material level and competitors of aptamers, have not been used as a platform for aptamer selection yet so far. In this study, a glycan-imprinted magnetic nanoparticles (MNPs)-based SELEX was developed to efficiently screen aptamers against glycoproteins. Glycan-imprinted MNPs were used as an affinity interface to bind target glycoprotein, and then the target glycoprotein-bound MNPs were used as an affinity substrate for aptamer selection. The glycan-imprinted MNPs were synthesized by a state-of-the-art imprinting approach called boronate affinity controllable oriented surface imprinting. The glycan-imprinted MNPs exhibited high affinity and specificity and therefore allowed preferential binding toward target glycoproteins while excluding unwanted species. Two representative glycoproteins, including RNase B and transferrin, were employed as target glycoproteins, and aptamers with high affinity and specificity toward the two target glycoproteins were screened out in 3 rounds. This method exhibited some merits, such as high affinity, fast speed, and avoiding negative screening. Therefore, the glycan-imprinted MNP-based SELEX approach holds great values for the efficient screening of high-performance aptamers. ...
Nanoparticle-Mediated Acoustic Cavitation Enables High Intensity Focused Ultrasound Ablation Without Tissue Heating
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-19 ,DOI:10.1021/acsami.8b15368
While thermal ablation of various solid tumors has been demonstrated using high intensity focused ultrasound (HIFU), the therapeutic outcomes of this technique are still unsatisfactory because of common recurrence of thermally ablated cancers and treatment side effects due to the high ultrasound intensity and acoustic pressure requirements. More precise ablation of tumors can be achieved by generating cavitating bubbles in the tissue using shorter pulses with higher acoustic pressures, which induce mechanical damage rather than thermal. However, it has remained as a challenge to safely deliver the acoustic pressures required for mechanical ablation of solid tumors. Here, we report a method to achieve mechanical ablation at lower acoustic pressures by utilizing phospholipid-stabilized hydrophobic mesoporous silica nanoparticles (PL-hMSN). The PL-hMSNs act as seeds for nucleation of cavitation events and thus significantly reduce the peak negative pressures and spatial-average temporal-average HIFU intensities needed to achieve mechanical ablation. Substantial mechanical damage was observed in the red blood cell or tumor spheroid containing tissue mimicking phantoms at PL-hMSN concentrations as low as 10 μg mL–1, after only 5 s of HIFU treatment with peak negative pressures ∼11 MPa and duty cycles ∼0.01%. Even the application of HIFU (peak negative pressure of 16.8 MPa and duty cycle of 0.017%) for 1 min in the presence of PL-hMSN (200 μg mL–1) did not cause any detectable temperature increase in tissue-mimicking phantoms. In addition, the mechanical effects of cavitation promoted by PL-hMSNs were observed up to 0.5 mm from the center of the cavitation events. This method may thus also improve delivery of therapeutics or nanoparticles to tumor environments with limited macromolecular transport. ...
Multivalent Antibody–Nanoparticle Conjugates To Enhance the Sensitivity of Surface-Enhanced Raman Scattering-Based Immunoassays
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-26 ,DOI:10.1021/acsami.8b13180
Multivalent immunoprobes can improve the sensitivity of biosensors because increased valency can strengthen the binding affinity between the receptor and target biomolecules. Here, we report surface-enhanced Raman scattering (SERS)-based immunoassays using multivalent antibody-conjugated nanoparticles (NPs) for the first time. Multivalent antibodies were generated through the ligation of Fab fragments fused with Fc-binding peptides to immunoglobulin G. This fabrication method is easy and fast because of the elimination of heterologous protein expression, high degrees of antibody modifications, and covalent chemical ligation steps. We constructed multivalent antibody–NP conjugates (MANCs) and employed them as SERS immunoprobes. MANCs improved the sensitivity of SERS-based immunoassays by 100 times compared to standard antibody–NP conjugates. MANCs will increase the feasibility of practical SERS-based immunoassays. ...
Noncovalent PEG Coating of Nanoparticle Drug Carriers Improves the Local Pharmacokinetics of Rectal Anti-HIV Microbicides
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-04 ,DOI:10.1021/acsami.8b12214
Antiretroviral drug nanocarriers hold great promise for developing anti-human immunodeficiency virus (HIV) rectal microbicides. However, challenges remain, namely, concerning which properties are more suited for enhancing colorectal distribution and retention of microbicide compounds. In this work, we developed and assessed the in vitro and in vivo performance of poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles (NPs) as carriers for the model drug efavirenz (EFV). We particularly focused on the effect of noncovalent poly(ethylene glycol) coating of PLGA NPs (PEG–PLGA NPs) conferring a mucus-diffusive behavior on the pharmacokinetics (PK) of EFV following rectal administration to mice. Drug-loaded PLGA NPs and PEG–PLGA NPs (200–225 nm) were obtained by nanoprecipitation. Both types of systems were able to retain native antiretroviral activity of EFV in vitro, while featuring lower cytotoxicity against different epithelial cell lines and HIV target cells. Also, PLGA NPs and PEG–PLGA NPs were readily taken up by colorectal cell lines and mildly reduced EFV permeation while increasing membrane retention in Caco-2 and Caco-2/HT29-MTX cell monolayer models. When administered intrarectally to CD-1 mice in phosphate-buffered saline (pH 7.4), EFV-loaded PEG–PLGA NPs consistently provided higher drug levels in colorectal tissues and lavages, as compared to free EFV or drug-loaded PLGA NPs. Mean values for the area-under-the-curve between 15 min and 12 h following administration were particularly higher for PEG–PLGA NPs in distal and middle colorectal tissues, with relative bioavailability values of 3.7 and 29, respectively, as compared to free EFV (2.2 and 6.0 over PLGA NPs, respectively). Systemic exposure to EFV was reduced for all treatments. NPs were further shown safe after once-daily administration for 14 days, as assessed by histological analysis of colorectal tissues and chemokine/cytokine assay of rectal lavages. Overall, PEG–PLGA NPs demonstrated to be safe carriers for rectal microbicide drug delivery and able to provide enhanced local PK that could be valuable in preventing rectal HIV transmission. ...
Photothermally Enabled Pyro-Catalysis of a BaTiO3 Nanoparticle Composite Membrane at the Liquid/Air Interface
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-13 ,DOI:10.1021/acsami.8b03411
This paper reports the highly efficient pyroelectric nanomaterial-based catalytic degradation of waste dye under rapid temperature oscillation, which was achieved by periodical solar irradiation on a porous pyroelectric membrane that was floating at the liquid/air interface. Such a membrane consists of the light-to-heat conversion carbon black film as the top layer and the porous poly(vinylidene difluoride) (PVDF) film embedded with pyroelectric barium titanate (BaTiO3) nanoparticles (BTO NPs) as the bottom layer. By using an optical chopper, solar light can be modulated to periodically irradiate on the floating membrane. Because of the photothermal effect and low thermal conductivity of the PVDF polymer, the generated heat is localized at the surface of the membrane and substantially increases the surface temperature within a short period of time. When the solar light is blocked by the chopper, interfacial evaporation through the porous membrane along with convective air cooling and radiative cooling leads to heat dissipation, and then the temperature of the membrane is rapidly decreased. Such an efficient thermal cycle results in a substantial rate of temperature change of the membrane, which enhances its pyroelectric capability and subsequent pyro-catalysis. In contrast, the efficiency of pyro-catalysis through the dispersed BTO NP solution is about 4 times lower than that of the BTO composite membrane. With the large heat capacity of the aqueous solution and inevitable thermal loss because of bulk heating, the rate of temperature change of the BTO NP solution is much smaller than that of the BTO composite membrane and thus results in a relatively small pyro-catalytic capability. Furthermore, the reusability and transferability of this newly developed composite membrane make it amenable to practical use in treating contaminated water. The findings in our report not only offer a new design strategy for efficient solar-enabled pyro-catalysis but also pave a new way to rationally harvest solar–thermal energy in nature for various applications that involve pyroelectric materials. ...
Self-Assembled Coumarin Nanoparticle in Aqueous Solution as Selective Mitochondrial-Targeting Drug Delivery System
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-16 ,DOI:10.1021/acsami.7b17711
The development of specifically targeted nanoparticles for subcellular organelles modified with a low-molecular-weight organic compound as drug nanocarriers can bring about wide applications in cancer therapy. However, their utility has been hampered by low selectivity, poor biodistribution, and limited efficiency. Herein, we report the aggregation behavior of a triphenylphosphonium-appended coumarin probe (TPP-C) in an aqueous solution and its applications as a mitochondria-targeting probe, and drug delivery carrier, which is a rare example for a low molecular-weight organic compound. The TPP-C formed homogeneous nanoparticles with small diameters in water as well as in mixtures of organic solvents and water. In pure water, the homogeneous nanoparticles induced J-aggregation, whereas in mixed solvents, the homogeneous nanoparticles induced H-aggregation. The luminescence intensities of nanoparticles originated from the aggregation-induced emission (AIE) effect in pure water and also in mixtures of organic solvents and water. These findings indicate that the AIE effect of TPP-C was dependent on the solvent. More interestingly, the TPP-C nanoparticles selectively accumulated in mitochondria. The TPP-C nanoparticles alone exhibited noncytotoxicity toward cancer cells. However, with the encapsulation of the anticancer drug doxorubicin (DOX) into the TPP-C nanoparticles, the DOX was efficiently delivered to the mitochondria. These results indicated that the proposed system demonstrates promise as a platform for future clinical medication, particularly for specific suborganelle-targeted drug delivery systems for cancer therapy. ...
ZnO Nanoparticles Modified with an Amphipathic Peptide Show Improved Photoprotection in Skin
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-24 ,DOI:10.1021/acsami.8b08431
ZnO nanoparticles of different sizes were functionalized with an amphipathic peptide, and its effect on nanoparticle stabilization and UV photoprotective activity was studied in this article. ...
Full-Color Tunable Fluorescent and Chemiluminescent Supramolecular Nanoparticles for Anti-counterfeiting Inks
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-31 ,DOI:10.1021/acsami.8b14110
Herein, with a series of conjugated polymers and based on the host–guest driven self-assembly strategy, a color-tunable supramolecular nanoparticle-based system is reported, in which full-color as well as white fluorescence can be achieved. ...
DNA-Functionalized Porous Fe3O4 Nanoparticles for the Construction of Self-Powered miRNA Biosensor with Target Recycling Amplification
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-17 ,DOI:10.1021/acsami.8b15419
The system is composed of indium tin oxide cathode and graphene oxide/gold nanoparticle/glucose oxidase anode. Redox probe of [Fe(CN)6]3– is entrapped inside porous Fe3O4 nanoparticles by DNA. ...
Maghemite Nanoparticles with Enhanced Magnetic Properties: One-Pot Preparation and Ultrastable Dextran Shell
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-07 ,DOI:10.1021/acsami.7b18411
As a proof of concept, a secondary layer of chitosan assures a positive charge to the nanoparticle surface, thus enhancing cellular internalization. ...
Reactive Porphyrin Adsorption on TiO2 Anatase Particles: Solvent Assistance and the Effect of Water Addition
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-05-01 ,DOI:10.1021/acsami.8b00894
Here, we report on two different approaches to decorate anatase TiO2 nanoparticle powders with 2H-tetraphenylporphyrin (2HTPP) molecules: (i) porphyrin adsorption in dispersions of organic liquids and (ii) gas-phase functionalization where evaporated porphyrin molecules attach to dehydrated particle ...
Tumor Catalytic–Photothermal Therapy with Yolk–Shell Gold@Carbon Nanozymes
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-25 ,DOI:10.1021/acsami.7b17916
Here, we report a novel nanozyme with yolk–shell structure fabricated by combining a single gold nanoparticle core with a porous hollow carbon shell nanospheres (Au@HCNs). ...
Magnetic and Electric Resonances in Particle-to-Film-Coupled Functional Nanostructures
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-11 ,DOI:10.1021/acsami.7b16941
We use gold-core/poly(N-isopropylacrylamide)-shell nanoparticles to self-assemble a monolayer of well-separated plasmonic particles, introduce a gradient in the nanoparticle size by an overgrowth process, and finally add a coupling metal film by evaporation. ...
A Carboxyl-Terminated Dendrimer Enables Osteolytic Lesion Targeting and Photothermal Ablation of Malignant Bone Tumors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-19 ,DOI:10.1021/acsami.8b15827
The dendrimer encapsulated with platinum nanoparticle predominantly accumulates at the osteolytic lesions around bone tumors rather than at healthy bone tissues in vivo. ...
Structure–Property of Lithium–Sulfur Nanoparticles via Molecular Dynamics Simulation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-19 ,DOI:10.1021/acsami.8b09128
The complex distribution of these sulfide and polysulfide speciation are dictated by both stoichiometry and local atomic structures in the nanoparticle. These findings will provide insight into further development of functionalized lithium–sulfur cathodes. ...
In Situ Fabrication of a Nickel/Molybdenum Carbide-Anchored N-Doped Graphene/CNT Hybrid: An Efficient (Pre)catalyst for OER and HER
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-08 ,DOI:10.1021/acsami.8b09941
Herein, a new Ni/MoxC (MoC, Mo2C) nanoparticle-supported N-doped graphene/carbon nanotube hybrid (NC) catalyst is developed via a facile, one-step integrated strategy, which can catalyze both the HER and OER in an efficient and robust manner. ...
Albumin-Stabilized Metal–Organic Nanoparticles for Effective Delivery of Metal Complex Anticancer Drugs
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-04 ,DOI:10.1021/acsami.8b12812
The resultant BSA/Cu/NQ nanoparticle (BSA/Cu/NQ NP) showed good stability in different physiological buffers and could target tumors through the enhanced permeability and retention effect and receptor-mediated cellular uptake. ...
Gadolinium Metallofullerene-Polypyrrole Nanoparticles for Activatable Dual-Modal Imaging-Guided Photothermal Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-20 ,DOI:10.1021/acsami.8b09670
Here, we report an activatable dual-modal imaging agent, which is based on PEGylated-gadolinium metallofullerene-polypyrrole nanoparticle (PEG-GMF-PPy NP) for imaging-guided PTT. ...
Plasmon-Triggered Hot-Spot Excitation on SERS Substrates for Bacterial Inactivation and in Situ Monitoring
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-23 ,DOI:10.1021/acsami.8b09035
Here, using Ag nanoparticle-grafted tungsten oxide films (WO3/Ag), we developed a multifunctional platform that may act as a surface-enhanced Raman spectroscopy substrate for sensitively capturing and counting bacteria. ...
Nano-Protrusive Gold Nanoparticle-Hybridized Polymer Thin Film as a Sensitive, Multipatternable, and Antifouling Biosensor Platform
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-13 ,DOI:10.1021/acsami.8b03681
Hybrid films consisting of anisotropic octahedral gold nanoparticles (AuNPs) and polymers had their surfaces functionalized and were immobilized on surface plasmon resonance (SPR) sensors for biomolecule detection. Specifically, carboxylated octahedral AuNPs (C-Oh-AuNPs) and poly(allylamine hydrochloride) (PAH) were assembled as ultrathin films by using a layer-by-layer process. The ionic strength generated from the functional groups of C-Oh-AuNP and PAH influenced the composition, its surface morphology, and the reactivity of the film toward further chemical reactions such as the synthesis of spherical AuNPs (S-AuNPs). We were thus able to control the size and the structure of the C-Oh-AuNP and S-AuNPs converted to nano-raspberry-shaped particles. This hierarchical AuNP hybrid film exhibits much more sensitive and stable detection of biomolecules than regular flat chip systems, and this result may be due to the SPR of the AuNP at its surface being able to markedly enhance the local optical field of the chip. The micropatterning of the hybrid coating was also studied by using a soft lithographic patterning method. We, in particular, worked on creating multiplex patterns having different combinations of shapes and fluorescent colors. We expect our hybrid coating system with multicode biomolecular arrays to be used as a powerful platform for biosensor applications. ...
Metal–Organic Frameworks-Derived Carbon Nanoparticles for Photoacoustic Imaging-Guided Photothermal/Photodynamic Combined Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-11-28 ,DOI:10.1021/acsami.8b15828
Moreover, it is observed that the phototherapy effects and photoacoustic (PA) signal of ZCNs could be enhanced with the increase in the nanoparticle size. ...
Microneedle-Mediated Delivery of Lipid-Coated Cisplatin Nanoparticles for Efficient and Safe Cancer Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-24 ,DOI:10.1021/acsami.8b12926
The cisplatin-nanoparticle microneedle system developed in this study may offer promising opportunities in cancer therapy for enhancing antitumor effects and reducing systemic toxicity and side effects. ...
Ultrafast Achievement of a Superhydrophilic/Hydrophobic Janus Foam by Femtosecond Laser Ablation for Directional Water Transport and Efficient Fog Harvesting
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-05 ,DOI:10.1021/acsami.8b11894
Herein, we report a simple and low-cost method to rapidly fabricate nanoparticle-covered microstructures on one side of a copper foam surface, using one-step femtosecond laser direct writing technology, which enormously improved processing efficiency. ...
Ternary-Responsive Drug Delivery with Activatable Dual Mode Contrast-Enhanced in Vivo Imaging
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-13 ,DOI:10.1021/acsami.8b10564
Acid, oxidative stress and redox sensitive manganese oxide (MnOx) coated superparamagnetic iron oxide nanoparticle (SPION) were employed as nanolids to regulate the camptothecin drug release from the channels of mesoporous silica and achieve responsive dual-mode MRI contrast. ...
ATP-Decorated Mesoporous Silica for Biomineralization of Calcium Carbonate and P2 Purinergic Receptor-Mediated Antitumor Activity against Aggressive Lymphoma
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-02-14 ,DOI:10.1021/acsami.7b18729
Our results suggest that this nanocomposite has unique effects with respect to the morphology and properties of calcium carbonate on the surface of the nanoparticle. ...
Fast IR-Actuated Shape-Memory Polymers Using in Situ Silver Nanoparticle-Grafted Cellulose Nanocrystals
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-22 ,DOI:10.1021/acsami.8b10159
In recent years, shape-memory polymers (SMPs) have gained a key position in the realm of actuating applications from daily life products to biomedical and aeronautic devices. Most of these SMPs rely mainly on shape changes upon direct heat exposure or after stimulus conversion (e.g., magnetic field and light) to heat, but this concept remains significantly limited when both remote control and fine actuation are demanded. In the present study, we propose to design plasmonic silver nanoparticles (AgNPs) grafted onto cellulose nanocrystals (CNCs) as an efficient plasmonic system for fast and remote actuation. Such CNC-g-AgNPs “nanorod-like” structures thereby allowed for a long-distance and strong coupling plasmonic effect between the AgNPs along the CNC axis, thus ensuring a fast photothermal shape-recovery effect upon IR light illumination. To demonstrate the fast and remote actuation promoted by these structures, we incorporated them at low loading (1 wt %) into poly(ε-caprolactone) (PCL)-based networks with shape-memory properties. These polymer matrix networks were practically designed from biocompatible PCL oligomers end-functionalized with maleimide and furan moieties in the melt on the basis of thermoreversible Diels–Alder reactions. The as-produced materials could find application in the realm of soft robotics for remote object transportation or as smart biomaterials such as self-tightening knots with antibacterial properties related to the presence of the AgNPs. ...
Magnetic Cell–Scaffold Interface Constructed by Superparamagnetic IONP Enhanced Osteogenesis of Adipose-Derived Stem Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-12 ,DOI:10.1021/acsami.8b17427
Furthermore, the magnetic property of the IONPs proved to be the key factor in enhancing osteogenic differentiation, which explained the superior osteogenic capacity of the magnetic scaffolds compared with that of the gold nanoparticle-assembled scaffold. ...
Enhanced Metabolic Activity of Cytochrome P450 via Carbon Nanocage-Based Photochemical Bionanoreactor
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-11-27 ,DOI:10.1021/acsami.8b14810
Herein, a novel light-driven enzymatic bionanoreactor is designed with the gold nanoparticle (NP)-modified carbon nanocage (Au@CNC) as a nanoreactor and meso-tetrakis(4-carboxyphenyl)porphyrin (TCPP) as a photosensitizer for cytochrome P450-mediated drug metabolism. ...
Multilayer Ag-Embedded Silica Nanostructure as a Surface-Enhanced Raman Scattering-Based Chemical Sensor with Dual-Function Internal Standards
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-11-12 ,DOI:10.1021/acsami.8b12640
The key issues in developing quantitative analysis methods by using SERS spectroscopy are the fabrication of reliable SERS-active materials such as nanoparticle-based structures and the acquisition of the SERS signal without any disturbance that may change the SERS signal intensity and frequency. ...
Highly Efficient and Environmentally Stable Flexible Color Converters Based on Confined CH3NH3PbBr3 Nanocrystals
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-29 ,DOI:10.1021/acsami.8b11706
We use nanoparticle metal oxide (MOx) thin films as porous scaffolds of controlled nanopores size distribution to synthesize nc-MAPbBr3 through the infiltration of perovskite liquid precursors. ...
Fast-Response Flexible Photochromic Gels for Self-Erasing Rewritable Media and Colorimetric Oxygen Indicator Applications
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-19 ,DOI:10.1021/acsami.8b09825
In this work, a strategy based on the integration of TiO2 nanoparticle (NP) photocatalytic color switching of redox dyes and poly(vinyl alcohol) gel matrix could produce robust and flexible photochromic gels (FPGs) that exhibit fast light-responsive time and high photoreversible stability. ...
Hybrid Decorated Core@Shell Janus Nanoparticles as a Flexible Platform for Targeted Multimodal Molecular Bioimaging of Cancer
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-07 ,DOI:10.1021/acsami.8b10452
In this work, we report a novel Janus nanoplatform by combining an Fe3O4 NPs/mesoporous silica core@shell face together with an Au nanoparticle face. ...
Reactive Oxygen Species-Responsive Nanoparticles Based on PEGlated Prodrug for Targeted Treatment of Oral Tongue Squamous Cell Carcinoma by Combining Photodynamic Therapy and Chemotherapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-24 ,DOI:10.1021/acsami.8b08269
In this study, a reactive oxygen species (ROS)-responsive nanoparticle system was designed for combining photodynamic therapy (PDT) and chemotherapy for oral tongue squamous cell carcinoma (OTSCC)-targeted treatment. ...
Achieving High Energy Density and Low Loss in PVDF/BST Nanodielectrics with Enhanced Structural Homogeneity
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-21 ,DOI:10.1021/acsami.8b10354
Herein, mussel-inspired poly(dopamine) (PDA)-modified BaSrTiO3 (mBST) nanoparticle and poly(vinylidene fluoride) (PVDF) matrix are bonded together to fabricate nanocomposites with a cross-linked network and enhanced compatibility. ...
Paclitaxel-Induced Ultrasmall Gallic Acid-Fe@BSA Self-Assembly with Enhanced MRI Performance and Tumor Accumulation for Cancer Theranostics
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-20 ,DOI:10.1021/acsami.8b10625
Here, a large, self-assembled nanoparticle was designed for cancer theranostics and used with paclitaxel (PTX) to assemble bovine serum albumin-coated ultrasmall gallic acid-Fe(III) (GA-Fe@BSA-PTX) nanoparticles by the hydrophobic effect. ...
Macrophage-Mediated Exocytosis of Elongated Nanoparticles Improves Hepatic Excretion and Cancer Phototherapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-01 ,DOI:10.1021/acsami.8b10302
The introduction of nanoparticle-mediated delivery and therapy has revolutionized cancer treatment approaches. However, there has been limited success in clinical trials because current approaches have not simultaneously satisfied therapeutic efficacy and biosafety criteria to an adequate degree. ...
Origin of Hydrophilic Surface Functionalization-Induced Thermal Conductance Enhancement across Solid–Water Interfaces
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-13 ,DOI:10.1021/acsami.8b03709
Thermal transport across solid–water interfaces is critical for a wide range of applications such as solar thermal evaporation, nanoparticle-assisted hyperthermia therapeutics, and nanofluids. ...
Improved Triboelectric Nanogenerator Output Performance through Polymer Nanocomposites Filled with Core–shell-Structured Particles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-18 ,DOI:10.1021/acsami.8b05966
Core–shell-structured BaTiO3–poly(tert-butyl acrylate) (PtBA) nanoparticles are successfully prepared by in situ atom transfer radical polymerization of tert-butyl acrylate (tBA) on BaTiO3 nanoparticle surface. ...
Virus Spike and Membrane-Lytic Mimicking Nanoparticles for High Cell Binding and Superior Endosomal Escape
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-02 ,DOI:10.1021/acsami.8b06934
The ultimate virus-mimicking nanoparticle closely imitates the structures and functions of viruses, leading to robust transfection efficiency both in vitro and in vivo. ...
Surface Functionalization of Polymeric Nanoparticles with Umbilical Cord-Derived Mesenchymal Stem Cell Membrane for Tumor-Targeted Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-26 ,DOI:10.1021/acsami.8b05363
Here, we developed a poly(lactic-co-glycolic acid) (PLGA) nanoparticle with a layer of plasma membrane from umbilical cord MSC coating on the surface for tumor-targeted delivery of chemotherapy. ...
Stimuli-Responsive Nanocarrier for Co-delivery of MiR-31 and Doxorubicin To Suppress High MtEF4 Cancer
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-22 ,DOI:10.1021/acsami.8b07698
To achieve better therapeutic effect, a mesoporous silica nanoparticle-based controlled nanoplatform had been developed. ...
Spectral Dependence of Degradation under Ultraviolet Light in Perovskite Solar Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-25 ,DOI:10.1021/acsami.8b03024
This finding is valid for architectures with a range of electron transport layers, including SnO2, compact-TiO2, electron-beam TiO2, and nanoparticle-TiO2. ...
Superlight Adsorbent Sponges Based on Graphene Oxide Cross-Linked with Poly(vinyl alcohol) for Continuous Flow Adsorption
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-12 ,DOI:10.1021/acsami.8b06802
The GO nanosheets were completely immobilized in the sponge by cross-linking with PVA, and thus, there was no GO nanoparticle leaching or flushing out into the treated permeate water, which was another advantage over direct use of GO powders in water treatment. ...
Brain Targeting Delivery Facilitated by Ligand-Functionalized Layered Double Hydroxide Nanoparticles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-05 ,DOI:10.1021/acsami.8b04613
In this research, we designed and prepared a novel target nanoplatform, that is, layered double hydroxide (LDH) nanoparticle conjugated with targeting peptide-ligand Angiopep-2 (Ang2) or rabies virus glycoprotein (RVG) via intermatrix bovine serum albumin for brain targeting. ...
Surface Modification of Silicon Nanoparticles by an “Ink” Layer for Advanced Lithium Ion Batteries
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-01 ,DOI:10.1021/acsami.8b03000
Here, Prussian blue analogues (PBAs), widely used in ink, are deposited on the silicon nanoparticlesurface (PBAs@Si-450) to modify silicon nanoparticles with transition metal atoms and a N-doped carbon layer. ...
Structural Evolution of Metal (Oxy)hydroxide Nanosheets during the Oxygen Evolution Reaction
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-30 ,DOI:10.1021/acsami.8b02796
As opposed to nanosheets composed of pure NiOxHy, which dramatically reorganize under electrochemical conditions to form nanoparticle assemblies, restructuring is not found for Ni1−δCoδOxHy with a high Co content. ...
Dual Carbon-Confined SnO2 Hollow Nanospheres Enabling High Performance for the Reversible Storage of Alkali Metal Ions
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-25 ,DOI:10.1021/acsami.8b00605
Thereinto, hollow structures with sufficient void space could buffer the volume expansion, whereas dual carbon-confined strategy could not only elastically prevent the aggregation of nanoparticle and ensure the structural integrity but also immensely improve the conductivity and endow high rate properties ...
Near-Infrared Light-Activated Thermosensitive Liposomes as Efficient Agents for Photothermal and Antibiotic Synergistic Therapy of Bacterial Biofilm
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-23 ,DOI:10.1021/acsami.8b01327
The near-infrared-activated nanoparticle carriers had the tremendous therapeutic potential to dramatically enhance the efficacy of antibiotics through thermos-triggered drug release and photothermal therapy. ...
Self-Healing Phenomenon Observed During Capacity-Control Cycling of Freestanding Si-Based Composite Paper Anodes for Li-Ion Batteries
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-02-19 ,DOI:10.1021/acsami.7b19246
A different strategy of capacity-control cycling under fixed upper and lower capacity/voltage limits is used in an attempt to seek an extended cycle life for Si nanoparticle–multiwalled carbon nanotube (Si–MW) electrodes for Li-ion batteries. ...
Synthesis of Hierarchical Silica/Titania Hollow Nanoparticles and Their Enhanced Electroresponsive Activity
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-02-09 ,DOI:10.1021/acsami.7b18895
Wrinkled silica nanoparticle (WSN)-based hollow SiO2/TiO2 nanoparticles (W-HNPs) with hierarchically arrayed internal surfaces were prepared via the combination of sol–gel, TiO2 coating, and etching of core template techniques. ...
Multifunctional Gold Nanoparticle-Based Fluorescence Resonance Energy-Transfer Probe for Target Drug Delivery and Cell Fluorescence Imaging
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-09 ,DOI:10.1021/acsami.8b12897
Drug delivery system has a profound significance for imaging capabilities and monitoring apoptosis process precisely in cancer therapeutic field. Herein, we designed cysteamine (CS)-stabilized gold nanoparticles, CS–gold nanoparticles (AuNPs)–doxorubicin (DOX), for fluorescence-enhanced cell imaging and target drug delivery. For cancer therapy, DOX was incorporated to CS–AuNPs by disulfide linkages which could be cleaved by glutathione (GSH) in cancer cells specifically. In addition, red-emissive DOX was quenched effectively by particular quenching effect of fluorescence resonance energy transfer from DOX to AuNPs, rendering monitoring target drug release by visual luminescence. The released DOX-SH acted as an indicator for cancer cells with red fluorescence and was further used for stimuli-responsive drug therapy. After an overall investigation of detection for GSH, proapoptosis for cancer cells, and inhibition for tumor tissues in vivo, the CS–AuNPs–DOX nanoprobe shows an obviously enhanced performance. This proposal provides an intelligent strategy for cell imaging and drug delivery, which serves as a promising candidate for anticancer therapeutic applications. ...
MnO2 Nanowire–CeO2 Nanoparticle Composite Catalysts for the Selective Catalytic Reduction of NOx with NH3
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-12 ,DOI:10.1021/acsami.8b09605
MnOx-based catalysts have been applied to the selective catalytic reduction of NOx with ammonia (NH3) owing to their high NOx removal efficiency and catalytic stability. In general, the fabrication of a variety of nanomaterials in a complex structure requires complicated processes, including heat treatment and a series of cleaning steps. In addition, MnO2 which has diverse polymorphs, exhibits different catalytic effects depending on its crystalline structure. Among them, synthesizing the ε-MnO2 phase, which functions as a nanocatalyst, has been the most difficult and has hardly been reported. Here, we report the synthesis of heterostructured composite nanocatalysts consisting of ε-MnO2 nanowires (NWs) and CeO2 nanoparticles (NPs) by applying pulsed currents sequentially. This method drastically simplifies the overall process compared to the conventional techniques. Through X-ray diffraction and transmission electron microscopy, it was confirmed that 2–3 nm of CeO2 NPs were formed on the surfaces of the ε-MnO2 NWs. The de-NOx efficiency of the nanocatalysts was analyzed in terms of content variation, specific surface area, and the elemental chemical state of the surface. A ceramic filter containing the nanocatalysts shows a high catalytic activity over the broad operating temperature range 100–400 °C. In the low-temperature region, ε-MnO2 plays a major role in determining the catalytic property, which is consistent with the Brunauer−Emmett−Teller (BET), H2 temperature-programmed reduction (TPR), and X-ray photoelectron spectroscopy (XPS) results. On the other hand, in the high-temperature region, the efficiency increases gradually as the content of CeO2 increases. The H2 TPR, NH3-temperature-programmed desorption, and XPS patterns reveal why the composite exhibits such superior characteristics in the temperature range mentioned above. ...
Selective Electroless Metallization of Micro- and Nanopatterns via Poly(dopamine) Modification and Palladium Nanoparticle Catalysis for Flexible and Stretchable Electronic Applications
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-21 ,DOI:10.1021/acsami.8b07411
The authors report a new patterned electroless metallization process for creating micro- and nanoscale metallic structures on polymeric substrates, which are essential for emerging flexible and stretchable optical and electronic applications. This novel process features a selective adsorption of catalytic Pd nanoparticles (PdNPs) on a lithographically masked poly(dopamine) (PDA) interlayer in situ polymerized on the substrates. The moisture-resistant PDA layer has excellent stability under a harsh electroless plating bath, which enables electroless metallization on versatile substrate materials regardless of their hydrophobicity, and significantly strengthens the attachment of electroless plated metallic structures on the polymeric substrates. Prototype devices fabricated using this PDA-assisted electroless metallization patterning exhibit superior mechanical stability under high bending and stretching stress. The lithographic patterning of the PDA spatially confines the adsorption of PdNPs and reduces defects due to random adsorption of catalytic particles on the undesired area. The high resolution of the lithographic patterning enables the demonstration of a copper micrograting pattern with a linewidth down to 2 μm and a silver plasmonic nanodisk array with a 500 nm pitch. A copper mesh is also fabricated using our new patterned electroless metallization process and functions as flexible transparent electrodes with >80% visible transmittance and <1 Ω sq–1 sheet resistance. Moreover, flexible and stretchable dynamic electroluminescent displays and functional flexible printed circuits are demonstrated to show the promising capability of our fabrication process in versatile flexible and stretchable electronic devices. ...
Mechanically Robust Magnetic Fe3O4 Nanoparticle/Polyvinylidene Fluoride Composite Nanofiber and Its Application in a Triboelectric Nanogenerator
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-18 ,DOI:10.1021/acsami.8b07621
Mechanically robust composite nanofibers (NFs) with enhanced magnetic properties were made from polyvinylidene fluoride (PVDF) and Fe3O4 nanoparticles (NPs) by an electrospinning method. At up to 11.3 wt %, Fe3O4 NPs were embedded randomly in the PVDF NFs, but when the content exceeded 17 wt %, the NPs aggregated on the NF surfaces. Magnetization of the composite NFs consistently increased with the increasing Fe3O4 NP content. The mechanical strength of the Fe3O4 NP/PVDF composite NF was enhanced by a dispersion strengthening mechanism. A triboelectric nanogenerator was made from the composite, which showed enhanced output performance with the Fe3O4 NP content less than 11.3 wt %, but the performance degraded at higher content. These results were attributed to the electret doping effect and surface aggregation of the Fe3O4 NPs on the NFs, respectively. ...
Ultralarge Area Sub-10 nm Plasmonic Nanogap Array by Block Copolymer Self-Assembly for Reliable High-Sensitivity SERS
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-11 ,DOI:10.1021/acsami.8b17325
To this end, plasmonic nanoparticle (NP) arrays with narrow gaps or sharp tips have been suggested as desirable structures. We present a highly dense and uniform Au nanoscale gap array enabled by the customized design of NP shape and arrangement employing block copolymer self-assembly. ...
Novel Fluorescence Switch for MicroRNA Imaging in Living Cells Based on DNAzyme Amplification Strategy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-06 ,DOI:10.1021/acsami.8b15330
The gold nanoparticle (AuNP) probe was taken up by cells autonomously. Then, MnO2 nanosheets were reduced to Mn2+ by glutathione in cells and DNA modules were released. MiRNA 155 took away locker DNA by strand displacement reaction to activate the DNAzyme. ...
Binding of Lignin Nanoparticles at Oil–Water Interfaces: An Ecofriendly Alternative to Oil Spill Recovery
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-03 ,DOI:10.1021/acsami.8b17748
We find that the lignin nanoparticle adsorption to the oil–water interface is governed by a combination of electrostatic, van der Waals, and hydrophobic interactions between the particles and the interface. ...
Metal–Enzyme Nanoaggregates Eradicate Both Gram-Positive and Gram-Negative Bacteria and Their Biofilms
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-11-13 ,DOI:10.1021/acsami.8b14949
The nanoparticle (NP) synthesis approach applied protein desolvation and laccase-mediated NP stabilization to innovatively produce catalytically active α-amylase nanoparticles (αNPs) for the elimination of the bacterial biofilm. ...
Paclitaxel-Loaded Core–Shell Magnetic Nanoparticles and Cold Atmospheric Plasma Inhibit Non-Small Cell Lung Cancer Growth
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-10 ,DOI:10.1021/acsami.8b16487
Nanoparticle-based drug delivery allows effective and sustained delivery of therapeutic agents to solid tumors and has completely changed how cancer is treated. As a new technology for medical applications, cold atmospheric plasma (CAP) shows a great potential in selective cancer treatment. ...
Gold Nanoparticles Biosynthesized and Functionalized Using a Hydroxylated Tetraterpenoid Trigger Gene Expression Changes and Apoptosis in Cancer Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-17 ,DOI:10.1021/acsami.8b09206
Understanding the synthetic mechanisms and cell–nanoparticle interactions of biosynthesized and functionalized gold nanoparticles (AuNPs) using natural products is of great importance for developing their applications in nanomedicine. ...
Fabrication of Strain Gauges via Contact Printing: A Simple Route to Healthcare Sensors Based on Cross-Linked Gold Nanoparticles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-16 ,DOI:10.1021/acsami.8b12057
First, 1,9-nonanedithiol cross-linked gold nanoparticle (GNP) films were prepared via layer-by-layer (LbL) spin-coating and subsequently transferred onto flexible polyimide foil by contact printing. ...
Wafer-Scale Ultrathin, Single-Crystal Si and GaAs Photocathodes for Photoelectrochemical Hydrogen Production
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-18 ,DOI:10.1021/acsami.8b10943
Pt nanoparticle-decorated 16 μm thick spalled Si with an np+ rear junction exhibited an HER onset potential of 332 mV (vs reversible hydrogen electrode (RHE)) and a photocurrent density of 20.1 mA cm–2 at 0 V (vs RHE), which are the best performances among previously reported planar-type thin Si-based ...
High-Performance Photopolymerized Poly(vinyl alcohol)/Silica Nanocomposite Hydrogels with Enhanced Cell Adhesion
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-09 ,DOI:10.1021/acsami.8b09026
Subsequently, the PVA–GMA/methacrylate-functionalized silica nanoparticle (MSi)-based nanocomposite hydrogels are developed via the photopolymerization approach. ...
Sandwich DNA Hybridization Fluorescence Resonance Energy-Transfer Strategy for miR-122 Detection by Core–Shell Upconversion Nanoparticles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-18 ,DOI:10.1021/acsami.8b03429
An upconversion nanoparticle (UCNP)-based fluorescence resonance energy-transfer (FRET) strategy is normally restricted by the complicated preparations, low energy-transfer efficiency, and the challenge on improving specificity. ...
Modular Construction of Photoanodes with Covalently Bonded Ru- and Ir-Polypyridyl Visible Light Chromophores
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-13 ,DOI:10.1021/acsami.8b06605
1,10-phenanthroline is grafted to indium tin oxide (ITO) and titanium dioxide nanoparticle (TiO2) semiconductors by electroreduction of 5-diazo-1,10-phenanthroline in 0.1 M H2SO4. ...
 
Li and Mg Co-Doped Zinc Oxide Electron Transporting Layer for Highly Efficient Quantum Dot Light-Emitting Diodes
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-06 ,DOI:10.1021/acsami.8b04721
Zinc-oxide (ZnO) is widely used as an n-type electron transporting layer (ETL) for quantum dot (QD) light-emitting diode (QLED) because various metal doping can be possible and ZnO nanoparticle can be processed at low temperatures. ...
In Situ Preparation of Cobalt Nanoparticles Decorated in N-Doped Carbon Nanofibers as Excellent Electromagnetic Wave Absorbers
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-21 ,DOI:10.1021/acsami.8b05211
The solid Co/N-C NFs have lengths up to dozens of microns with an average diameter of ca. 500 nm and possess abundant cobalt nanoparticles on both the surface and within the fibers, and the cobalt nanoparticle size is about 20 nm. ...
Coadministration of iRGD with Multistage Responsive Nanoparticles Enhanced Tumor Targeting and Penetration Abilities for Breast Cancer Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-21 ,DOI:10.1021/acsami.8b04847
This multistage-responsive nanoparticle, IDDHN, was comprised of an NO donor-modified hyaluronic acid (HN) shell and a small-sized dendrimer, namely, dendri-graft-l-lysine conjugated with doxorubicin and indocyanine (IDD). ...
Quantum Dot Fullerene-Based Molecular Beacon Nanosensors for Rapid, Highly Sensitive Nucleic Acid Detection
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-05-25 ,DOI:10.1021/acsami.8b03552
With the quenching property and its small size compared with other nanoparticle-based quenchers, it is advantageous to group a QD reporter and multiple C60-labeled oligonucleotide probes to construct a molecular beacon (MB) probe for sensitive, robust nucleic acid detection. ...
Electrohydrodynamic Printing of Microscale PEDOT:PSS-PEO Features with Tunable Conductive/Thermal Properties
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-05-21 ,DOI:10.1021/acsami.8b04051
Most of the existing EHD printing studies for conductive features were based on metallic nanoparticleinks in a microdripping mode, which exhibited relatively low efficiency and commonly required high-temperature annealing process to achieve high conductivity. ...
Applications of Light-Responsive Systems for Cancer Theranostics
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-19 ,DOI:10.1021/acsami.8b01114
Because of the disadvantages of UV light such as phototoxicity and limited tissue penetration depth, scientists have moved the research focus onto developing nanoparticle systems responsive to light in the visible region (400–700 nm), aiming to reduce the phototoxicity. ...
Ceria Nanoparticles-Decorated Microcapsules as a Smart Drug Delivery/Protective System: Protection of Encapsulated P. pyralis Luciferase
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-17 ,DOI:10.1021/acsami.7b19658
By varying the nanoparticle concentration in the microcapsule, it is possible to control the level of core shielding, from ROS filtering to complete blocking. ...
Quantitative SERS Detection of Dopamine in Cerebrospinal Fluid by Dual-Recognition-Induced Hot Spot Generation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-24 ,DOI:10.1021/acsami.8b01063
This was realized by first immobilizing 3,3′-dithiodipropionic acid di(N-hydroxysuccinimide ester) on gold thin film surfaces to capture DA, followed by introducing 3-mercaptophenylboronic acid (3-MPBA)-functionalized silver nanoparticles to generate numerous plasmonic “hot spots” with the nanoparticle-on-mirror ...
Synthesis of Magnetite–Semiconductor–Metal Trimer Nanoparticles through Functional Modular Assembly: A Magnetically Separable Photocatalyst with Photothermic Enhancement for Water Reduction
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-27 ,DOI:10.1021/acsami.7b17046
The experimental results show that the semiconductor acts as an active component for photocatalysis, the metal nanoparticle acts as a cocatalyst for enhancement of charge separation, and the Fe3O4 component helps in the convenient separation of catalysts in magnetic field and improves photocatalytic ...
Metal–Organic Frameworks-Derived Hierarchical Co3O4 Structures as Efficient Sensing Materials for Acetone Detection
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-26 ,DOI:10.1021/acsami.7b17669
Benefits from structural advantages, core–shell, and porous core–shell Co3O4 exhibit enhanced sensing performance compared to those of porous popcorn and nanoparticle Co3O4 to acetone gas. ...
MOF Nanoparticles with Encapsulated Autophagy Inhibitor in Controlled Drug Delivery System for Antitumor
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-11 ,DOI:10.1021/acsami.7b16522
The cellular uptake in HeLa cells of 3-MA encapsulated in ZIF-8 (3-MA@ZIF-8 NPs) is facilitated through the nanoparticle internalization with reference to TEM observations and the quantitative analyses of zinc by ICP-MS. ...
On-Particle Rolling Circle Amplification-Based Core–Satellite Magnetic Superstructures for MicroRNA Detection
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-08 ,DOI:10.1021/acsami.7b16293
Herein, for the first time, we utilize on-particle rolling circle amplification (RCA) to prepare rapidly responsive core–satellite magnetic superstructures with a high load of magnetic nanoparticle (MNP) satellites. ...
Magnetite- and Iodine-Containing Nanoemulsion as a Dual Modal Contrast Agent for X-ray/Magnetic Resonance Imaging
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-26 ,DOI:10.1021/acsami.8b19517
In this study, we investigated efficient superparamagnetic iron oxide nanoparticle (SPION)-loaded iodinated nano-emulsions (NEs) as dual modal injectable CAs for X-ray imaging and MRI. ...
Combinatory Cancer Therapeutics with Nanoceria-Capped Mesoporous Silica Nanocarriers through pH-triggered Drug Release and Redox Activity
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-24 ,DOI:10.1021/acsami.8b17958
The combination of DOX with COP (COP@DOX-MSN) showed even higher ROS level, demonstrating a cytotoxic synergism of drug and nanoparticle in terms of ROS generation. ...
Combining Porous Magnetic Ni@C Nanospheres and CaCO3 Microcapsule as Surface-Enhanced Raman Spectroscopy Sensing Platform for Hypersensitive C-Reactive Protein Detection
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-18 ,DOI:10.1021/acsami.8b13061
The final solution containing the signal molecule was dropped on the Ag nanoparticle substrate, and the signal could be enhanced by Ag particles. First, rhodamine B was encapsulated in the CaCO3 microcapsule when it precipitated to form microcubes. ...
Temperature-Induced Denaturation of BSA Protein Molecules for Improved Surface Passivation Coatings
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-17 ,DOI:10.1021/acsami.8b13749
Circular dichroism spectroscopy, dynamic light scattering, and nanoparticle tracking analysis showed that temperature-induced denaturation of BSA proteins in bulk solution resulted in irreversible unfolding and protein oligomerization, thereby converting weakly adhesive protein monomers into a more adhesive ...
Dual Activity of Rose Bengal Functionalized to Albumin-Coated Lanthanide-Doped Upconverting Nanoparticles: Targeting and Photodynamic Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-06 ,DOI:10.1021/acsami.8b08919
It was estimated that approximately 112 molecules of BSA were present and cross-linked per NaGdF4:Yb3+/Er3+ nanoparticle. Analysis of the BSA structural behavior on the Ln-UCNP surfaces displayed up to 80% loss of α-helical content. ...
Paclitaxel-Loaded Self-Assembled Lipid Nanoparticles as Targeted Drug Delivery Systems for the Treatment of Aggressive Ovarian Cancer
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-07-20 ,DOI:10.1021/acsami.8b08125
More importantly, the nanoparticle-based PTX treatments, with or without EGFR targeting, reduced the tumor burden by 50% compared to PTX or nondrug control in an ovarian cancer mouse xenograft model. ...
Photoresponsive Nanovehicle for Two Independent Wavelength Light-Triggered Sequential Release of P-gp shRNA and Doxorubicin To Optimize and Enhance Synergistic Therapy of Multidrug-Resistant Cancer
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-05-29 ,DOI:10.1021/acsami.8b03823
To this end, a photoresponsive mesoporous silica nanoparticle (PMSN) is fabricated as a co-delivery vehicle of P-glycoprotein (P-gp) short-hairpin RNA (shRNA) and photocaged prodrug of doxorubicin (DOX), by which the orthogonal and sequential release of shRNA and DOX can be achieved using an external ...
Highly Stable Graphene-Based Nanocomposite (GO–PEI–Ag) with Broad-Spectrum, Long-Term Antimicrobial Activity and Antibiofilm Effects
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-05-16 ,DOI:10.1021/acsami.8b03185
Various silver nanoparticle (AgNP)-decorated graphene oxide (GO) nanocomposites (GO–Ag) have received increasing attention owing to their antimicrobial activity and biocompatibility; however, their aggregation in physiological solutions and the generally complex synthesis methods warrant improvement. ...
Bouquet-Like Mn2SnO4 Nanocomposite Engineered with Graphene Sheets as an Advanced Lithium-Ion Battery Anode
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-05-16 ,DOI:10.1021/acsami.8b04164
The obtained composite material presents a bouquet structure containing manganese and tin oxide nanoparticle network with graphene sheets. ...
Effect of Surface Modification on Water Adsorption and Interfacial Mechanics of Cellulose Nanocrystals
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-02-20 ,DOI:10.1021/acsami.7b18803
However, there are still numerous obstacles that prevent these materials from achieving optimal performance, including high water adsorption, poor nanoparticle dispersion, and filler properties that vary in response to moisture. ...
Ultrasensitive Enzyme-free Biosensor by Coupling Cyclodextrin Functionalized Au Nanoparticles and High-Performance Au-Paper Electrode
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-17 ,DOI:10.1021/acsami.7b17037
First, a porous structure of gold nanoparticle (AuNP)-modified paper working electrode (Au-PWE), with a feature of all-round conductivity and plenty of active sites favoring biological ligand attachment, was fabricated as a sensor substrate. ...
Multifunctional Bi@PPy-PEG Core–Shell Nanohybrids for Dual-Modal Imaging and Photothermal Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-03 ,DOI:10.1021/acsami.7b17838
The obtained Bi@PPy-PEG NHs have a distinct core–shell structure with the metallic Bi nanoparticle as the inner core and the PPy-PEG layer as the shell. The Bi@PPy-PEG NHs show excellent physiological stability and compatibility, without noticeable cytotoxicity. ...
Enhanced Solar Light Absorption and Photoelectrochemical Conversion Using TiN Nanoparticle-Incorporated C3N4–C Dot Sheets
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-08 ,DOI:10.1021/acsami.7b15066
In this work, a promising strategy to increase the broadband solar light absorption was developed by synthesizing a composite of metal-free carbon nitride–carbon dots (C3N4–C dots) and plasmonic titanium nitride (TiN) nanoparticles (NPs) to improve the photoelectrochemical water-splitting performance under simulated solar radiation. Hot-electron injection from plasmonic TiN NPs to C3N4 played a role in photocatalysis, whereas C dots acted as catalysts for the decomposition of H2O2 to O2. The use of C dots also eliminated the need for a sacrificial reagent and prevented catalytic poisoning. By incorporating the TiN NPs and C dots, a sixfold improvement in the catalytic performance of C3N4 was observed. The proposed approach of combining TiN NPs and C dots with C3N4 proved effective in overcoming low optical absorption and charge recombination losses and also widens the spectral window, leading to improved photocatalytic activity. ...
Capsule-Integrated Polypeptide Multilayer Films for Effective pH-Responsive Multiple Drug Co-Delivery
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-14 ,DOI:10.1021/acsami.8b17264
., growth factors) and nanoparticles, achieving bovine serum albumin loading of 80 μg cm–2 and release of 2 weeks, and histone loading of 100 μg cm–2 and release of 6 weeks; which also enable Staphylococcus aureus killing efficacy of 83% while maintaining osteoblast viability of >85% with silver nanoparticle ...
In Situ Synthesis and Unprecedented Electrochemical Performance of Double Carbon Coated Cross-Linked Co3O4
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-11-28 ,DOI:10.1021/acsami.8b15604
Herein, we report a novel structure of double carbon-coated Co3O4 cross-linked composite, where the Co3O4 nanoparticle is in situ covered by nitrogen-doped carbon and further connected by carbon nanotubes (Co3O4 NP@NC@CNTs). ...
Gold–Palladium Nanoalloys Supported by Graphene Oxide and Lamellar TiO2 for Direct Synthesis of Hydrogen Peroxide
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-11-13 ,DOI:10.1021/acsami.8b17342
The sandwich-like AuPd nanoalloy comprising 1 wt % nanoparticle of an equimolar mixture of Au and Pd with 6 wt % GO and 93 wt % TiO2 supports shows a promising catalytic performance toward the DSHP reaction with H2O2 productivity and selectivity of 5.50 mol H2O2 gmetal–1 h–1 and 64%, respectively. ...
Superior High-Rate and Ultralong-Lifespan Na3V2(PO4)3@C Cathode by Enhancing the Conductivity Both in Bulk and on Surface
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-15 ,DOI:10.1021/acsami.8b12055
Herein, we propose a facile approach for significantly enhancing the electrochemical properties of Na3V2(PO4)3 by Ti doping at V site and constructing nanoparticle@carbon core–shell nanostructure. ...
Self-Regulated Carboxyphenylboronic Acid-Modified Mesoporous Silica Nanoparticles with “Touch Switch” Releasing Property for Insulin Delivery
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-06-22 ,DOI:10.1021/acsami.8b06998
Accordingly, we designed a mesoporous silica nanoparticle (MSN)-based glucose-sensitive and self-regulated drug release system to achieve the goal of long circulation and “touch switch” in vivo. ...
Highly Active and Durable Core–Shell fct-PdFe@Pd Nanoparticles Encapsulated NG as an Efficient Catalyst for Oxygen Reduction Reaction
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-05-23 ,DOI:10.1021/acsami.8b04060
Here, we have developed a new type of face-centered tetragonal (fct) PdFe-alloy nanoparticle-encapsulated Pd (fct-PdFe@Pd) anchored onto nitrogen-doped graphene (NG). This core–shell fct-PdFe@Pd@NG hybrid is fabricated by a facile and cost-effective technique. ...
Design of Mannose-Functionalized Curdlan Nanoparticles for Macrophage-Targeted siRNA Delivery
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-19 ,DOI:10.1021/acsami.8b02073
Furthermore, CMI nanoparticle efficiently delivered siRNA against tumor necrosis factor α (TNFα) to lipopolysaccharide-stimulated primary mouse peritoneal macrophages. ...
Ultrasmall TiO2-Coated Reduced Graphene Oxide Composite as a High-Rate and Long-Cycle-Life Anode Material for Sodium-Ion Batteries
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-04-23 ,DOI:10.1021/acsami.8b03722
Herein, we have synthesized ultrasmall TiO2-nanoparticle-coated reduced graphene oxide (TiO2@RGO) composites by using a one-pot hydrolysis method, which are then investigated as anode materials for SIBs. ...
Transferrable Plasmonic Au Thin Film Containing Sub-20 nm Nanohole Array Constructed via High-Resolution Polymer Self-Assembly and Nanotransfer Printing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-01-10 ,DOI:10.1021/acsami.7b16401
In addition, other types of Au nanostructure arrays such as geometry-controlled NHA and nanoparticlearrays (NPAs) shows the outstanding versatility of our approach. ...
Electrochemical SERS for in Situ Monitoring the Redox States of PEDOT and Its Potential Application in Oxidant Detection
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-12-28 ,DOI:10.1021/acsami.8b16989
Poly(EDOT-OH) films were coated on Au nanoparticle-coated ITO glass as SERS-active substrates. Taking the advantage of Raman enhancement, we can in situ and clearly monitor the redox behavior of poly(EDOT-OH) in aqueous solutions. ...
Effect of Silica Supports on Plasmonic Heating of Molecular Adsorbates as Measured by Ultrafast Surface-Enhanced Raman Thermometry
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-11-14 ,DOI:10.1021/acsami.8b14858
Herein, we probe the effects of catalytic supports on heating in plasmon-driven catalysis by examining various gold nanoparticle oxide systems. ...
Hierarchically Designed Ag@Ce6Mo10O39 Marigold Flower-Like Architectures: An Efficient Electrode Material for Hybrid Supercapacitors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-10-19 ,DOI:10.1021/acsami.8b12527
We facilely prepared silver nanoparticle-decorated Ce6Mo10O39 marigold flower-like structures (Ag NPs@CM MFs) for use as an effective positive material in hybrid supercapacitors (HSCs). ...
Highly Conductive Fiber with Waterproof and Self-Cleaning Properties for Textile Electronics
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-28 ,DOI:10.1021/acsami.8b10217
The fabrication process of the highly conductive fiber involves coating of a commercial Kevlar fiber with Ag nanoparticle–poly(styrene-block-butadiene-block-styrene) polymer composites. ...
Biomimetic Shells Endow Sub-50 nm Nanoparticles with Ultrahigh Paclitaxel Payloads for Specific and Robust Chemotherapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-25 ,DOI:10.1021/acsami.8b11571
Herein, poly(ester amide) polymers composed of cationic and hydrophobic segments were formulated with a paclitaxel/human serum albumin (PTX/HSA) complex, as well as free PTX, to construct a core–shell nanoparticle (NP) platform with the interior simultaneously reserving PTX and PTX/HSA complex, while ...
Acidic Dressing Based on Agarose/Cs2.5H0.5PW12O40 Nanocomposite for Infection Control in Wound Care
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-09-06 ,DOI:10.1021/acsami.8b09066
The wound care safety of this material is due to low release of heavy metal heteropolyanions ([PW12O40]3–), no nanoparticle leaching, and proton controlled release resulting in nonirritating acid levels for human skin models. ...
Superior Bactericidal Efficacy of Fucose-Functionalized Silver Nanoparticles against Pseudomonas aeruginosa PAO1 and Prevention of Its Colonization on Urinary Catheters
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-23 ,DOI:10.1021/acsami.8b09475
Thus, strategies which can modulate the bacterial cell–silver nanoparticle interactions thereby reducing the amount of nanoparticles required to kill a typical number of bacterial cells are utmost welcomed. ...
Three-in-One Self-Assembled Nanocarrier for Dual-Drug Delivery, Two-Photon Imaging, and Chemo-Photodynamic Synergistic Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2018-08-14 ,DOI:10.1021/acsami.8b07270
The dual-drug-loaded nanoparticle Fu/LD@RuCD (Fu: 5-fluorouracil; LD: lonidamine) effectively penetrates into cancer cells in 8 h and selectively accumulates in lysosomes, in which dual-drug release is promoted by the mildly acidic environment. ...
Nanoparticle Ligand Exchange and Its Effects at the Nanoparticle–Cell Membrane Interface
Nano Letters (IF 12.279) Pub Date : 2018-10-18 ,DOI:10.1021/acs.nanolett.8b02638
Herein, we describe a family of gold nanoparticles (AuNPs) of the same core size (∼13 nm core), modified with 12 different kinds of surface ligands, and the effects of their exchangeable ligands on both nanoparticle−supported lipid bilayers (SLBs) and nanoparticle−natural cell membrane interfaces. ...
Controlling and Predicting Nanoparticle Formation by Block Copolymer Directed Rapid Precipitations
Nano Letters (IF 12.279) Pub Date : 2018-01-10 ,DOI:10.1021/acs.nanolett.7b04674
Here, the FNP process is shown to strictly obey diffusion-limited aggregation assembly kinetics, and the parameters that control the nanoparticle size and the polymer brush density on the nanoparticle surface are shown. ...
Unusual multiscale mechanics of biomimetic nanoparticle hydrogels.
Nature Communications (IF 11.878) Pub Date : 2018-01-12 ,DOI:10.1038/s41467-017-02579-w
A computational model accounting for the difference in nanoparticle interactions for variable GSH configurations describes the unusual trends of nanoparticle gel viscoelasticity. ...
Gold nanoparticle biodissolution by a freshwater macrophyte and its associated microbiome
Nature Nanotechnology (IF 33.407) Pub Date : 2018-08-13 ,DOI:10.1038/s41565-018-0231-y
Nanoparticle biotransformation in these compartments should not be ignored, even for nanoparticles commonly considered to be stable in the environment. ...
Formation of self-assembled gold nanoparticle supercrystals with facet-dependent surface plasmonic coupling.
Nature Communications (IF 11.878) Pub Date : 2018-06-18 ,DOI:10.1038/s41467-018-04801-9
Here we report the formation of self-assembled 3D faceted gold nanoparticle supercrystals with controlled nanoparticle packing and unique facet-dependent optical property by using a binary solvent diffusion method. ...
Metagenomic analysis of microbial communities yields insight into impacts of nanoparticle design
Nature Nanotechnology (IF 33.407) Pub Date : 2018-01-15 ,DOI:10.1038/s41565-017-0029-3
Given that nanoparticle morphology remained constant, the potential influence of gold dissolution was minimal. Surface coating governed the nanoparticle partitioning between the bioparticulate and aqueous phases. ...
Apparent self-heating of individual upconverting nanoparticle thermometers.
Nature Communications (IF 11.878) Pub Date : 2018-11-21 ,DOI:10.1038/s41467-018-07361-0
To resolve this apparent contradiction between model and experiment, we systematically vary the nanoparticle's thermal environment: the substrate thermal conductivity, nanoparticle-substrate contact resistance, and nanoparticle size. ...
Assembly of Protein Stacks With in Situ Synthesized Nanoparticle Cargo
Nano Letters (IF 12.279) Pub Date : 2018-07-31 ,DOI:10.1021/acs.nanolett.8b02055
Ordered nanoparticle assemblies are a subject of widespread interest due to the potential to harness their emergent functions. In this work, the toroidal-shaped form of the protein peroxiredoxin, which has a pore size of 7 nm, was used to organize iron oxyhydroxide nanoparticles. ...
Thermodynamic Driving Force in the Spontaneous Formation of Inorganic Nanoparticle Solutions
Nano Letters (IF 12.279) Pub Date : 2018-03-05 ,DOI:10.1021/acs.nanolett.7b05187
We show molecular interactions at the nanoparticle interface are the driving force in high-concentration nanoparticle solutions. ...
Density-Gradient Control over Nanoparticle Supercrystal Formation
Nano Letters (IF 12.279) Pub Date : 2018-08-13 ,DOI:10.1021/acs.nanolett.8b02910
Consequently, we developed a new method based upon the density difference between two layers of solvents to control nanoparticle superlattice formation and growth. ...
Ordered Surface Structuring of Spherical Colloids with Binary Nanoparticle Superlattices
Nano Letters (IF 12.279) Pub Date : 2018-03-29 ,DOI:10.1021/acs.nanolett.8b00173
Consequently, the non-equilibrium conditions present during nanoparticle self-assembly are difficult to control to eventually achieve the desired material structures. ...
Single quantum dot tracking reveals the impact of nanoparticle surface on intracellular state.
Nature Communications (IF 11.878) Pub Date : 2018-05-08 ,DOI:10.1038/s41467-018-04185-w
Here we apply live-cell single-quantum-dot imaging and tracking to analyze and classify nanoparticlestates after intracellular delivery. ...
Differences in Nanoparticle Uptake in Transplanted and Autochthonous Models of Pancreatic Cancer
Nano Letters (IF 12.279) Pub Date : 2018-03-21 ,DOI:10.1021/acs.nanolett.7b04043
Noninvasive optical imaging was employed to examine the pharmacology and biodistribution of these various nanoparticle formulations in both allografted and autochthonous mouse models of PDAC. ...
Nanoparticle Organization Controls Their Potency as Universal Glues for Gels
Nano Letters (IF 12.279) Pub Date : 2018-05-08 ,DOI:10.1021/acs.nanolett.8b00586
Our findings represent an important step toward rationalizing this new class of nanoparticle-based adhesives. ...
Disordered Nanoparticle Packings under Local Stress Exhibit Avalanche-Like, Environmentally Dependent Plastic Deformation
Nano Letters (IF 12.279) Pub Date : 2018-08-20 ,DOI:10.1021/acs.nanolett.8b01640
These results suggest how disordered nanoparticle packings may be expected to behave in devices operating under varying environments. ...
Size-, Shape-, and Composition-Dependent Model for Metal Nanoparticle Stability Prediction
Nano Letters (IF 12.279) Pub Date : 2018-04-02 ,DOI:10.1021/acs.nanolett.8b00670
First-principles methods such as density functional theory (DFT) are capable of capturing accurate nanoalloy energetics; however, they are limited to very small nanoparticle sizes (<2 nm in diameter) due to their computational cost. ...
Ultrafast Pulse Generation in an Organic Nanoparticle-Array Laser
Nano Letters (IF 12.279) Pub Date : 2018-03-26 ,DOI:10.1021/acs.nanolett.8b00531
Here we demonstrate, for the first time, an organic dye nanoparticle-array laser with more than a 100 GHz modulation bandwidth. We show that the lasing modulation speed can be tuned by the array parameters. ...
DNA-Mediated Size-Selective Nanoparticle Assembly for Multiplexed Surface Encoding
Nano Letters (IF 12.279) Pub Date : 2018-03-23 ,DOI:10.1021/acs.nanolett.8b00509
Multiplexed surface encoding is achieved by positioning two different sizes of gold nanocubes on gold surfaces with precisely defined locations for each particle via template-confined, DNA-mediated nanoparticle assembly. ...
Direct observation of polymer surface mobility via nanoparticle vibrations.
Nature Communications (IF 11.878) Pub Date : 2018-07-25 ,DOI:10.1038/s41467-018-04854-w
Here, we introduce a methodology of Brillouin light spectroscopy to reveal polymer surface mobility via nanoparticle vibrations. ...
Sustained Release of Immunosuppressant by Nanoparticle-anchoring Hydrogel Scaffold Improved the Survival of Transplanted Stem Cells and Tissue Regeneration
Theranostics (IF 8.063) Pub Date : 2018-01-01 ,DOI:10.7150/thno.22072
In the present study, the sustained release of immunosuppressant for the purpose of improving the survival of stem cells was successfully realized by a nanoparticle-anchoring hydrogel scaffold we developed. ...
Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy
Theranostics (IF 8.063) Pub Date : 2018-02-12 ,DOI:10.7150/thno.22621
This work focuses on understanding how tumor vascular permeability is influenced by AuNP-augmented RT, and how this effect can be used to improve the delivery of nanoparticle chemotherapeutics. ...
Targeting Tumor Hypoxia Using Nanoparticle-engineered CXCR4-overexpressing Adipose-derived Stem Cells
Theranostics (IF 8.063) Pub Date : 2018-02-02 ,DOI:10.7150/thno.22736
To harness this mechanism for targeting tumor hypoxia, we developed polymeric nanoparticle-induced CXCR4-overexpressing human adipose-derived stem cells (hADSCs). ...
Nanoparticle-induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes
Nature Nanotechnology (IF 33.407) Pub Date : 2018-04-02 ,DOI:10.1038/s41565-018-0085-3
The potential for maternal nanoparticle (NP) exposures to cause developmental toxicity in the fetus without the direct passage of NPs has previously been shown, but the mechanism remained elusive. ...
Optimization of a Degradable Polymer–Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells
Nano Letters (IF 12.279) Pub Date : 2018-09-20 ,DOI:10.1021/acs.nanolett.8b02917
Using experimental design, a statistical approach to optimization that reduces experimental burden, we demonstrate herein that these degradable polymer–lipid nanoparticles can be optimized in terms of polymer synthesis and nanoparticle formulation to achieve a multiple order-of-magnitude increase in ...
Reprogramming Tumor-Associated Macrophages by Nanoparticle-Based Reactive Oxygen Species Photogeneration
Nano Letters (IF 12.279) Pub Date : 2018-10-24 ,DOI:10.1021/acs.nanolett.8b03568
Here we successfully reprogrammed TAMs to an antitumor M1 phenotype using precision nanoparticle-based reactive oxygen species photogeneration, which demonstrated superior efficiency and efficacy over lipopolysaccharide stimulation. ...
Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA
Nano Letters (IF 12.279) Pub Date : 2018-05-08 ,DOI:10.1021/acs.nanolett.8b01101
To facilitate the treatment of diseases associated with aberrant gene upregulation and downregulation, we sought to co-formulate siRNA and mRNA in a single lipidoid nanoparticle (LNP) formulation. ...
Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics.
Nature Communications (IF 11.878) Pub Date : 2018-10-31 ,DOI:10.1038/s41467-018-06730-z
The progress of nanoparticle (NP)-based drug delivery has been hindered by an inability to establish structure-activity relationships in vivo. ...
Nanoparticle Delivery of miRNA-21 Mimic to Cardiac Macrophages Improves Myocardial Remodeling after Myocardial Infarction
Nano Letters (IF 12.279) Pub Date : 2018-08-29 ,DOI:10.1021/acs.nanolett.8b02578
Our work thus presents a new therapeutic strategy to manipulate macrophage phenotype using nanoparticle delivery of miRNA-21 with a potential for use to attenuate post-MI remodeling and heart failure. ...
Increasing lean muscle mass in mice via nanoparticle-mediated hepatic delivery of follistatin mRNA
Theranostics (IF 8.063) Pub Date : 2018-10-22 ,DOI:10.7150/thno.27847
Methods: The therapy is based on nanoparticle-mediated delivery of follistatin messenger RNA (mRNA) to the liver after subcutaneous administration. ...
Photoacoustic Image-Guided Delivery of Plasmonic-Nanoparticle-Labeled Mesenchymal Stem Cells to the Spinal Cord
Nano Letters (IF 12.279) Pub Date : 2018-09-10 ,DOI:10.1021/acs.nanolett.8b03305
In this work, we present a combined ultrasound and photoacoustic imaging tool to provide image-guided needle placement and monitoring of nanoparticle-labeled stem cell delivery into the spinal cord. ...
Real-space imaging with pattern recognition of a ligand-protected Ag374 nanocluster at sub-molecular resolution.
Nature Communications (IF 11.878) Pub Date : 2018-07-27 ,DOI:10.1038/s41467-018-05372-5
High-resolution real-space imaging of nanoparticle surfaces is desirable for better understanding of surface composition and morphology, molecular interactions at the surface, and nanoparticle chemical functionality in its environment. ...
Nanoparticles as multimodal photon transducers of ionizing radiation
Nature Nanotechnology (IF 33.407) Pub Date : 2018-03-26 ,DOI:10.1038/s41565-018-0086-2
In these applications, the nanoparticle is often viewed as a carrier inert to ionizing radiation from the radionuclide. ...
Magnesium Nanoparticle Plasmonics
Nano Letters (IF 12.279) Pub Date : 2018-05-23 ,DOI:10.1021/acs.nanolett.8b00955
Nanoparticles of some metals (Cu/Ag/Au) sustain oscillations of their electron cloud called localized surface plasmon resonances (LSPRs). These resonances can occur at optical frequencies and be driven by light, generating enhanced electric fields and spectacular photon scattering. However, current plasmonic metals are rare, expensive, and have a limited resonant frequency range. Recently, much attention has been focused on earth-abundant Al, but Al nanoparticles cannot resonate in the IR. The earth-abundant Mg nanoparticles reported here surmount this limitation. A colloidal synthesis forms hexagonal nanoplates, reflecting Mg’s simple hexagonal lattice. The NPs form a thin self-limiting oxide layer that renders them stable suspended in 2-propanol solution for months and dry in air for at least two week. They sustain LSPRs observable in the far-field by optical scattering spectroscopy. Electron energy loss spectroscopy experiments and simulations reveal multiple size-dependent resonances with energies across the UV, visible, and IR. The symmetry of the modes and their interaction with the underlying substrate are studied using numerical methods. Colloidally synthesized Mg thus offers a route to inexpensive, stable nanoparticles with novel shapes and resonances spanning the entire UV-vis-NIR spectrum, making them a flexible addition to the nanoplasmonics toolbox. ...
Engineering Ni–Mo–S Nanoparticles for Hydrodesulfurization
Nano Letters (IF 12.279) Pub Date : 2018-05-02 ,DOI:10.1021/acs.nanolett.8b00472
Nanoparticle engineering for catalytic applications requires both a synthesis technique for the production of well-defined nanoparticles and measurements of their catalytic performance. ...
Catalytic Nanotruss Structures Realized by Magnetic Self-Assembly in Pulsed Plasma
Nano Letters (IF 12.279) Pub Date : 2018-04-16 ,DOI:10.1021/acs.nanolett.8b00718
nanotruss structures is a direct result of the polydisperse nanoparticle distribution. ...
The Interfacial Assembly of Polyoxometalate Nanoparticle Surfactants
Nano Letters (IF 12.279) Pub Date : 2018-03-26 ,DOI:10.1021/acs.nanolett.8b00208
Polyoxometalates (POMs) using {Mo72V30} as an example, dissolved in water, can interact with amine-terminated polydimethylsiloxane (PDMS-NH2) dissolved in toluene at the water/toluene interface to form POM-surfactants that significantly lower the interfacial tension and can be used to stabilize liquids via interfacial elasticity. The jamming of the POM-surfactants at the water/oil interface with consequent wrinkling occurs with a decrease in the interfacial area. The packing density of the POM-surfactants at the interface can be tuned by varying the strength of screening with the addition of cations with differing hydrated radii. ...
Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy
Nano Letters (IF 12.279) Pub Date : 2018-02-23 ,DOI:10.1021/acs.nanolett.7b05263
Here, a macrophage-membrane-coated nanoparticle is developed for tumor-targeted chemotherapy delivery with a controlled release profile in response to tumor microenvironment stimuli. ...
In Situ Liquid Cell TEM Reveals Bridge-Induced Contact and Fusion of Au Nanocrystals in Aqueous Solution
Nano Letters (IF 12.279) Pub Date : 2018-09-07 ,DOI:10.1021/acs.nanolett.8b03139
The discovery of this multistep process advances our understanding of the nanoparticle coalescence mechanism in aqueous solutions. ...
Negative regulation of cationic nanoparticle-induced inflammatory toxicity through the increased production of prostaglandin E2 via mitochondrial DNA-activated Ly6C+ monocytes.
Theranostics (IF 8.063) Pub Date : 2018-06-14 ,DOI:10.7150/thno.21693
Conclusion: Our findings suggest that Ly6C+ monocytes and mtDNA-induced Ly6C+ monocyte PGE2 production may be part of a feedback mechanism that contributes to the resolution of cationic nanocarrier-induced inflammatory toxicity and may have important implications for understanding nanoparticle biocompatibility ...
Route to Rheumatoid Arthritis by Macrophage-Derived Microvesicle-Coated Nanoparticles
Nano Letters (IF 12.279) Pub Date : 2018-12-10 ,DOI:10.1021/acs.nanolett.8b03439
A poly(lactic-co-glycolic acid) (PLGA) nanoparticle was subsequently coated with MMV, and the inflammation-mediated targeting capacity of the MNP was evaluated both in vitro and in vivo. ...
Modifying a Commonly Expressed Endocytic Receptor Retargets Nanoparticles in Vivo
Nano Letters (IF 12.279) Pub Date : 2018-09-20 ,DOI:10.1021/acs.nanolett.8b03149
Based on its microenvironmental regulation, we hypothesized Caveolin 1 (Cav1) would exert cell type-specific effects on nanoparticle delivery. ...
Continuous-wave upconverting nanoparticle microlasers
Nature Nanotechnology (IF 33.407) Pub Date : 2018-06-18 ,DOI:10.1038/s41565-018-0161-8
Reducing the size of lasers to microscale dimensions enables new technologies1 that are specifically tailored for operation in confined spaces ranging from ultra-high-speed microprocessors2 to live brain tissue3. However, reduced cavity sizes increase optical losses and require greater input powers to reach lasing thresholds. Multiphoton-pumped lasers4,5,6,7 that have been miniaturized using nanomaterials such as lanthanide-doped upconverting nanoparticles (UCNPs)8 as lasing media require high pump intensities to achieve ultraviolet and visible emission and therefore operate under pulsed excitation schemes. Here, we make use of the recently described energy-looping excitation mechanism in Tm3+-doped UCNPs9 to achieve continuous-wave upconverted lasing action in stand-alone microcavities at excitation fluences as low as 14 kW cm−2. Continuous-wave lasing is uninterrupted, maximizing signal and enabling modulation of optical interactions10. By coupling energy-looping nanoparticles to whispering-gallery modes of polystyrene microspheres, we induce stable lasing for more than 5 h at blue and near-infrared wavelengths simultaneously. These microcavities are excited in the biologically transmissive second near-infrared (NIR-II) window and are small enough to be embedded in organisms, tissues or devices. The ability to produce continuous-wave lasing in microcavities immersed in blood serum highlights practical applications of these microscale lasers for sensing and illumination in complex biological environments. ...
Nanoparticle elasticity directs tumor uptake.
Nature Communications (IF 11.878) Pub Date : 2018-01-09 ,DOI:10.1038/s41467-017-02588-9
To date, the role of elasticity in drug delivery remains elusive due to the inability to measure microscale mechanics and alter rheology without affecting chemistry. Herein, we describe the in vitro cellular uptake and in vivo tumor uptake of nanolipogels (NLGs). NLGs are composed of identical lipid bilayers encapsulating an alginate core, with tunable elasticity. The elasticity of NLGs was evaluated by atomic force microscopy, which demonstrated that they exhibit Young's moduli ranging from 45 ± 9 to 19,000 ± 5 kPa. Neoplastic and non-neoplastic cells exhibited significantly greater uptake of soft NLGs (Young's modulus <1.6 MPa) relative to their elastic counterparts (Young's modulus >13.8 MPa). In an orthotopic breast tumor model, soft NLGs accumulated significantly more in tumors, whereas elastic NLGs preferentially accumulated in the liver. Our findings demonstrate that particle elasticity directs tumor accumulation, suggesting that it may be a design parameter to enhance tumor delivery efficiency. ...
Single Particle Automated Raman Trapping Analysis.
Nature Communications (IF 11.878) Pub Date : 2018-10-15 ,DOI:10.1038/s41467-018-06397-6
The SPARTA platform opens up a wide range of new avenues for nanoparticle research through label-free integral high-throughput single particle analysis, overcoming key limitations in sensitivity and specificity of existing bulk analysis methods. ...
Sorting Metal Nanoparticles with Dynamic and Tunable Optical Driven Forces
Nano Letters (IF 12.279) Pub Date : 2018-06-28 ,DOI:10.1021/acs.nanolett.8b01672
The results provide new insights into all-optical nanoparticle manipulation and separation and reveal that there is still room to sort smaller nanoparticle with nanometer precision using dynamic phase-gradient forces. ...
Oxygenating the way for enhanced chemophototherapy.
Theranostics (IF 8.063) Pub Date : 2018-08-08 ,DOI:10.7150/thno.27810
This editorial highlights a study by Cai et al. [12] that a hemoglobin and human serum albumin hybrid protein nanoparticle can simultaneously deliver O2, chemotherapeutics, and photosensitizers to tumors for enhanced chemophototherapy. ...
Enabling nanoscale flexoelectricity at extreme temperature by tuning cation diffusion.
Nature Communications (IF 11.878) Pub Date : 2018-10-25 ,DOI:10.1038/s41467-018-06959-8
By combining electrical biasing and temperature-dependent in situ TEM with phase field simulations, we analyzed the resulting strain gradient and local polarization distribution within a single nanoparticle. ...
Fluorescent Silica Nanoparticles with Well-Separated Intensity Distributions from Batch Reactions
Nano Letters (IF 12.279) Pub Date : 2018-01-02 ,DOI:10.1021/acs.nanolett.7b04978
Silica chemistry provides pathways to uniquely tunable nanoparticle platforms for biological imaging. ...
In-situ observation of plasmon-controlled photocatalytic dehydrogenation of individual palladium nanoparticles.
Nature Communications (IF 11.878) Pub Date : 2018-11-07 ,DOI:10.1038/s41467-018-07108-x
Here, we visualize a plasmon-induced reaction at the sub-nanoparticle level in-situ and in real-time. ...
Creating Multifunctional Optofluidic Potential Wells for Nanoparticle Manipulation
Nano Letters (IF 12.279) Pub Date : 2018-10-29 ,DOI:10.1021/acs.nanolett.8b03844
Optical forces have enabled various nanomanipulation in microfluidics such as optical trapping, sorting, and transporting of nanoparticles (NPs), but the manipulation is usually specific with a certain optical field. Tightly focused Gaussian beams can trap NPs but not sort them; moderately focused Gaussian beams allow sorting microparticles in a flow but not NPs; quasi-Bessel beams can sort NPs in a flow but cannot control their positions due to low trapping stiffness. All these methods rely on the axial variation of laser intensity. Here we show that multifunctional and tunable optofluidic potential wells can be created for nanomanipulation by synchronizing optical phase gradient force with fluid drag force. We demonstrate controlled trapping and transporting of 150 nm Ag NPs over 10 μm and sorting of 80 and 100 nm Au NPs using optical line traps with tunable phase gradients in experiments. Our simulations further predict that simultaneous sorting and trapping of sub-50 nm Au NPs can be achieved with a sorting resolution of 1 nm using optimized optical fields. Our method provides great freedom and flexibility for nanomanipulation in optofluidics with potential applications in nanophotonics and biomedicine. ...
Second Harmonic Spectroscopy of Surface Lattice Resonances
Nano Letters (IF 12.279) Pub Date : 2018-12-11 ,DOI:10.1021/acs.nanolett.8b03574
Because of their large figures of merit, surface lattice resonances (SLRs) in metal nanoparticle arrays are very promising for chemical and biomolecular sensing in both liquid and gas media. ...
Programmable Metal/Semiconductor Nanostructures for mRNA-Modulated Molecular Delivery
Nano Letters (IF 12.279) Pub Date : 2018-09-11 ,DOI:10.1021/acs.nanolett.8b02263
These materials are composed of a central core gold nanoparticle surrounded by a layer of DNA-capped quantum dots. ...
Plasmonic control of multi-electron transfer and C-C coupling in visible-light-driven CO2 reduction on Au nanoparticles
Nano Letters (IF 12.279) Pub Date : 2018-02-06 ,DOI:10.1021/acs.nanolett.7b05410
Higher photon energies and/or flux favor simultaneous harvesting of more than one electron from the photocharged Au nanoparticle catalyst, inducing C-C coupling required for C2 production. ...
Targeted Delivery of Functionalized Upconversion Nanoparticles for Externally Triggered Photothermal/Photodynamic Therapies of Brain Glioblastoma
Theranostics (IF 8.063) Pub Date : 2018-02-04 ,DOI:10.7150/thno.22482
In this regard, a functionalized upconversion nanoparticle (UCNP)-based delivery system which can target brain tumor and convert deep tissue-penetrating near-infrared (NIR) light into visible light for precise phototherapies on brain tumor was developed in this work. ...
Enhancing Nanoparticle Diffusion on a Unidirectional Domain Wall Magnetic Ratchet
Nano Letters (IF 12.279) Pub Date : 2018-12-04 ,DOI:10.1021/acs.nanolett.8b04248
The performance of nanoscale magnetic devices is often limited by the presence of thermal fluctuations, whereas in micro- and nanofluidic applications the same fluctuations may be used to spread reactants or drugs. Here, we demonstrate the controlled motion and the enhancement of diffusion of magnetic nanoparticles that are manipulated and driven across a series of Bloch walls within an epitaxially grown ferrite garnet film. We use a rotating magnetic field to generate a traveling wave potential that unidirectionally transports the nanoparticles at a frequency tunable speed. Strikingly, we find an enhancement of diffusion along the propulsion direction and a frequency-dependent diffusion coefficient that can be precisely controlled by varying the system parameters. To explain the reported phenomena, we develop a theoretical approach that shows a fair agreement with the experimental data enabling an exact analytical expression for the enhanced diffusivity above the magnetically modulated periodic landscape. Our technique to control thermal fluctuations of driven magnetic nanoparticles represents a versatile and powerful way to programmably transport magnetic colloidal matter in a fluid, opening the doors to different fluidic applications based on exploiting magnetic domain wall ratchets. ...
Fabrication of Large-Area Arrays of Vertically Aligned Gold Nanorods
Nano Letters (IF 12.279) Pub Date : 2018-06-28 ,DOI:10.1021/acs.nanolett.8b01584
Anisotropic nanoparticles, such as nanorods and nanoprisms, enable packing of complex nanoparticlestructures with different symmetry and assembly orientation, which result in unique functions. ...
Multiple Heterojunction in Single Titanium Dioxide Nanoparticles for Novel Metal-Free Photocatalysis
Nano Letters (IF 12.279) Pub Date : 2018-06-27 ,DOI:10.1021/acs.nanolett.8b01245
However, localization of this disorder layer in a conventional single TiO2 nanoparticle with the heterojunction composed of anatase and rutile has remained a big challenge. ...
Evaluating the Mechanisms of Light-Triggered siRNA Release from Nanoshells for Temporal Control Over Gene Regulation
Nano Letters (IF 12.279) Pub Date : 2018-05-02 ,DOI:10.1021/acs.nanolett.8b00681
To enable spatiotemporal control over gene silencing, researchers have begun to develop nucleic acid-nanoparticle conjugates that keep their nucleic acid cargo inactive until it is released from the nanoparticle on-demand by externally applied near-infrared laser light. ...
Exosome-like Nanozyme Vesicles for H2O2-Responsive Catalytic Photoacoustic Imaging of Xenograft Nasopharyngeal Carcinoma
Nano Letters (IF 12.279) Pub Date : 2018-12-14 ,DOI:10.1021/acs.nanolett.8b03709
Thus, GQDzyme/ABTS nanoparticle is a novel type of catalytic PAI contrast agent, which is sensitive to H2O2 produced from NPC cells. ...
Author Correction: Intracellular localization of nanoparticle dimers by chirality reversal.
Nature Communications (IF 11.878) Pub Date : 2018-08-27 ,DOI:10.1038/s41467-018-06060-0
The original version of this Article contained an error in the spelling of the author Joong Hwan Bahng, which was incorrectly given as Joong Hwan Banhg. This has been corrected in both the PDF and HTML versions of the Article. ...
In utero nanoparticle delivery for site-specific genome editing.
Nature Communications (IF 11.878) Pub Date : 2018-06-26 ,DOI:10.1038/s41467-018-04894-2
Genetic diseases can be diagnosed early during pregnancy, but many monogenic disorders continue to cause considerable neonatal and pediatric morbidity and mortality. Early intervention through intrauterine gene editing, however, could correct the genetic defect, potentially allowing for normal organ development, functional disease improvement, or cure. Here we demonstrate safe intravenous and intra-amniotic administration of polymeric nanoparticles to fetal mouse tissues at selected gestational ages with no effect on survival or postnatal growth. In utero introduction of nanoparticles containing peptide nucleic acids (PNAs) and donor DNAs corrects a disease-causing mutation in the β-globin gene in a mouse model of human β-thalassemia, yielding sustained postnatal elevation of blood hemoglobin levels into the normal range, reduced reticulocyte counts, reversal of splenomegaly, and improved survival, with no detected off-target mutations in partially homologous loci. This work may provide the basis for a safe and versatile method of fetal gene editing for human monogenic disorders. ...
Nanoparticle-templated nanofiltration membranes for ultrahigh performance desalination.
Nature Communications (IF 11.878) Pub Date : 2018-05-21 ,DOI:10.1038/s41467-018-04467-3
Nanofiltration (NF) membranes with ultrahigh permeance and high rejection are highly beneficial for efficient desalination and wastewater treatment. Improving water permeance while maintaining the high rejection of state-of-the-art thin film composite (TFC) NF membranes remains a great challenge. Herein, we report the fabrication of a TFC NF membrane with a crumpled polyamide (PA) layer via interfacial polymerization on a single-walled carbon nanotubes/polyether sulfone composite support loaded with nanoparticles as a sacrificial templating material, using metal-organic framework nanoparticles (ZIF-8) as an example. The nanoparticles, which can be removed by water dissolution after interfacial polymerization, facilitate the formation of a rough PA active layer with crumpled nanostructure. The NF membrane obtained thereby exhibits high permeance up to 53.5 l m-2h-1 bar-1 with a rejection above 95% for Na2SO4, yielding an overall desalination performance superior to state-of-the-art NF membranes reported so far. Our work provides a simple avenue to fabricate advanced PA NF membranes with outstanding performance. ...
In vivo Imaging-Guided Nanoplatform for Tumor Targeting Delivery and Combined Chemo-, Gene- and Photothermal Therapy.
Theranostics (IF 8.063) Pub Date : 2018-12-18 ,DOI:10.7150/thno.28241
Db-modified survivin antisense oligonucleotide (db-DNA) which could inhibit survivin expression was then grafted on avidin at the outer layer of nanoparticle. ...
Awakening p53 in vivo by D-peptides-functionalized ultra-small nanoparticles: Overcoming biological barriers to D-peptide drug delivery
Theranostics (IF 8.063) Pub Date : 2018-10-22 ,DOI:10.7150/thno.27165
Keywords: gold nanoparticle, ultra-small nanoparticle, dextrorotary peptide, p53, biosafety ...
Block Copolymer Nanoparticles Remove Biofilms of Drug-Resistant Gram-Positive Bacteria by Nanoscale Bacterial Debridement
Nano Letters (IF 12.279) Pub Date : 2018-06-26 ,DOI:10.1021/acs.nanolett.8b01000
These nanoparticles diffuse into biofilms and attach to bacteria but do not kill them; instead, they promote the gradual dispersal of biofilm bacteria, probably because the solubility of the bacteria–nanoparticle complex is enhanced by the nanoparticle dextran shell. ...
Dewetting during Terahertz Vibrations of Nanoparticles
Nano Letters (IF 12.279) Pub Date : 2018-01-17 ,DOI:10.1021/acs.nanolett.7b03984
We use molecular simulations to demonstrate the formation of a vacuum layer around a vibrating nanoparticle in a liquid. This vacuum layer forms readily for high frequencies with respect to the characteristic vibrational (Einstein) frequency of the fluid, even with small amplitude vibrations. ...
Weak Measurement Enhanced Spin Hall Effect of Light for Particle Displacement Sensing
Nano Letters (IF 12.279) Pub Date : 2018-12-14 ,DOI:10.1021/acs.nanolett.8b04219
A spherical nanoparticle can scatter tightly focused optical beams in a spin-segmented manner, meaning that the far field of the scattered light exhibits laterally separated left- and right-handed circularly polarized components. ...
Long-Range Self-Assembly via the Mutual Lorentz Force of Plasmon Radiation
Nano Letters (IF 12.279) Pub Date : 2018-03-29 ,DOI:10.1021/acs.nanolett.8b00269
Experimentally, linearly polarized light illumination leads to the formation of 80 nm diameter Au nanoparticle chains, perpendicularly aligned, with lengths that are orders of magnitude greater than their plasmon near-field interaction. ...
Surface impact on nanoparticle-based magnetic resonance imaging contrast agents
Theranostics (IF 8.063) Pub Date : 2018-04-03 ,DOI:10.7150/thno.23789
Magnetic resonance imaging (MRI) is one of the most widely used diagnostic tools in the clinic. To improve imaging quality, MRI contrast agents, which can modulate local T1 and T2 relaxation times, are often injected prior to or during MRI scans. However, clinically used contrast agents, including Gd3+-based chelates and iron oxide nanoparticles (IONPs), afford mediocre contrast abilities. To address this issue, there has been extensive research on developing alternative MRI contrast agents with superior r1 and r2 relaxivities. These efforts are facilitated by the fast progress in nanotechnology, which allows for preparation of magnetic nanoparticles (NPs) with varied size, shape, crystallinity, and composition. Studies suggest that surface coatings can also largely affect T1 and T2 relaxations and can be tailored in favor of a high r1 or r2. However, the surface impact of NPs has been less emphasized. Herein, we review recent progress on developing NP-based T1 and T2 contrast agents, with a focus on the surface impact. ...
Dendrimer- and copolymer-based nanoparticles for magnetic resonance cancer theranostics
Theranostics (IF 8.063) Pub Date : 2018-11-29 ,DOI:10.7150/thno.27828
Keywords: dendrimer nanoparticle, copolymer nanoparticle, magnetic resonance, cancer theranostics ...
 

上一篇:2018年生物纳米研究经典报道(四)
下一篇:2018年生物纳米研究经典报道(六)
相关最新报道
疾病应用(检索)

Copyright©2020  Sunlipo Biotech Research Center for Nanomedicine(PubMed). All right reserved. 

 E-mail:sunlipotech@163.com(技术服务)info@med-nanotech.com(应用开发)

Tel:86-21-5127 9909    Fax:86-21-5193 6393

沪ICP备16052527号-1

沪公网安备 31011002001237号