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2018年生物纳米研究经典报道(六)
来源于:纳米医学网 | 作者: | 发布时间:2017-11-25 | 浏览:299



Structure–Property Relationships of Oligonucleotide Polyelectrolyte Complex Micelles
Nano Letters (IF 12.279) Pub Date : 2018-10-22 ,DOI:10.1021/acs.nanolett.8b03132
The length of the charged block controls the radius of the nanoparticle, while oligonucleotide length appears to have little impact on either size or shape. ...
Targeted nanoparticles for multimodal imaging of the receptor for advanced glycation end-products
Theranostics (IF 8.063) Pub Date : 2018-12-01 ,DOI:10.7150/thno.31515
This editorial highlights a multimodal nanoparticle-based imaging agent targeted at RAGE that was recently developed by Konopka and colleagues (Theranostics 2018; 8(18):5012-5024. doi:10.7150/thno.24791). ...
Optical and Thermophoretic Control of Janus Nanopen Injection into Living Cells
Nano Letters (IF 12.279) Pub Date : 2018-12-03 ,DOI:10.1021/acs.nanolett.8b03885
The pens are made of a gold nanoparticle attached to a dielectric alumina shaft. Balancing optical and thermophoretic forces in an optical tweezer allows single Janus nanopens to be trapped and positioned on the surface of living cells. ...
Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona
Nature Nanotechnology (IF 33.407) Pub Date : 2018-06-18 ,DOI:10.1038/s41565-018-0171-6
Once the nanocarrier is exposed to biological fluid such as plasma, however, its surface is inevitably covered with various biomolecules forming the protein corona, which masks the targeting ability of the nanoparticle. ...
Plasmon-Induced Magnetic Resonance Enhanced Raman Spectroscopy
Nano Letters (IF 12.279) Pub Date : 2018-03-08 ,DOI:10.1021/acs.nanolett.7b04385
These revelations are accomplished by designing a simple and practical metallic nanoparticle–film plasmonic system that generates magnetic resonances at visible-near-infrared frequencies. ...
Mass spectrometry and Monte Carlo method mapping of nanoparticle ligand shell morphology.
Nature Communications (IF 11.878) Pub Date : 2018-10-26 ,DOI:10.1038/s41467-018-06939-y
Janus, patchy, stripe-like, or random arrangements of molecules within the ligand shell of nanoparticles affect many properties. Among all existing ligand shell morphology characterization methods, the one based on mass spectroscopy is arguably the simplest. Its greatest limitation is that the results are qualitative. Here, we use a tailor-made Monte Carlo type program that fits the whole MALDI spectrum and generates a 3D model of the ligand shell. Quantitative description of the ligand shell in terms of nearest neighbor distribution and characteristic length scale can be readily extracted by the model, and are compared with the results of other characterization methods. A parameter related to the intermolecular interaction is extracted when this method is combined with NMR. This approach could become the routine method to characterize the ligand shell morphology of many nanoparticles and we provide an open access program to facilitate its use. ...
Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation.
Nature Communications (IF 11.878) Pub Date : 2018-10-16 ,DOI:10.1038/s41467-018-06603-5
Cell-free DNA (cfDNA) released from damaged or dead cells can activate DNA sensors that exacerbate the pathogenesis of rheumatoid arthritis (RA). Here we show that ~40 nm cationic nanoparticles (cNP) can scavenge cfDNA derived from RA patients and inhibit the activation of primary synovial fluid monocytes and fibroblast-like synoviocytes. Using clinical scoring, micro-CT images, MRI, and histology, we show that intravenous injection of cNP into a CpG-induced mouse model or collagen-induced arthritis rat model can relieve RA symptoms including ankle and tissue swelling, and bone and cartilage damage. This culminates in the manifestation of partial mobility recovery of the treated rats in a rotational cage test. Mechanistic studies on intracellular trafficking and biodistribution of cNP, as well as measurement of cytokine expression in the joints and cfDNA levels in systemic circulation and inflamed joints also correlate with therapeutic outcomes. This work suggests a new direction of nanomedicine in treating inflammatory diseases. ...
Effect of interstitial palladium on plasmon-driven charge transfer in nanoparticle dimers.
Nature Communications (IF 11.878) Pub Date : 2018-04-23 ,DOI:10.1038/s41467-018-04066-2
Capacitive plasmon coupling between noble metal nanoparticles (NPs) is characterized by an increasing red-shift of the bonding dipolar plasmon mode (BDP) in the classical electromagnetic coupling regime. This model breaks down at short separations where plasmon-driven charge transfer induces a gap current between the NPs with a magnitude and separation dependence that can be modulated if molecules are present in the gap. Here, we use gap contained DNA as a scaffold for the growth of palladium (Pd) NPs in the gap between two gold NPs and investigate the effect of increasing Pd NP concentration on the BDP mode. Consistent with enhanced plasmon-driven charge transfer, the integration of discrete Pd NPs depolarizes the capacitive BDP mode over longer interparticle separations than is possible in only DNA-linked Au NPs. High Pd NP densities in the gap increases the gap conductance and induces the transition from capacitive to conductive coupling. ...
An InP-based vortex beam emitter with monolithically integrated laser.
Nature Communications (IF 11.878) Pub Date : 2018-07-09 ,DOI:10.1038/s41467-018-05170-z
Semiconductor devices capable of generating a vortex beam with a specific orbital angular momentum (OAM) order are highly attractive for applications ranging from nanoparticle manipulation, imaging and microscopy to fiber and quantum communications. ...
Stimuli-Responsive Nanomedicines for Overcoming Cancer Multidrug Resistance
Theranostics (IF 8.063) Pub Date : 2018-01-01 ,DOI:10.7150/thno.22679
Eventually, we look forward to forthcoming intelligent nanoparticle systems with new mechanisms to deliver drugs for practical applications in conquering cancer MDR. ...
Anisotropic and Multicomponent Nanostructures by Controlled Symmetry Breaking of Metal Halide Intermediates
Nano Letters (IF 12.279) Pub Date : 2018-03-28 ,DOI:10.1021/acs.nanolett.7b05090
The Ag nanoparticle nucleates at and grows from a single point on the surface of the AgBr phase and the interface connecting these phases is atomically sharp. The complex nanostructures are generated at greater than 80% yield and are highly monodisperse in morphology and in size. ...
Less Is More: Enhancement of Second-Harmonic Generation from Metasurfaces by Reduced Nanoparticle Density
Nano Letters (IF 12.279) Pub Date : 2018-11-20 ,DOI:10.1021/acs.nanolett.8b03378
We investigate optical second-harmonic generation (SHG) from metasurfaces where noncentrosymmetric V-shaped gold nanoparticles are ordered into regular array configurations. In contrast to expectations, a substantial enhancement of the SHG signal is observed when the number density of the particles in the array is reduced. More specifically, by halving the number density, we obtain over 5-fold enhancement in SHG intensity. This striking result is attributed to favorable interparticle interactions mediated by the lattice, where surface-lattice resonances lead to spectral narrowing of the plasmon resonances. Importantly, however, the results cannot be explained by the improved quality of the plasmon resonance alone. Instead, the lattice interactions also lead to further enhancement of the local fields at the particles. The experimental observations agree very well with results obtained from numerical simulations including lattice interactions. ...
Microscopic mechanisms of deformation transfer in high dynamic range branched nanoparticle deformation sensors.
Nature Communications (IF 11.878) Pub Date : 2018-03-20 ,DOI:10.1038/s41467-018-03396-5
Nanoscale stress sensing is of crucial importance to biomechanics and other fields. An ideal stress sensor would have a large dynamic range to function in a variety of materials spanning orders of magnitude of local stresses. Here we show that tetrapod quantum dots (tQDs) exhibit excellent sensing versatility with stress-correlated signatures in a multitude of polymers. We further show that tQDs exhibit pressure coefficients, which increase with decreasing polymer stiffness, and vary >3 orders of magnitude. This high dynamic range allows tQDs to sense in matrices spanning >4 orders of magnitude in Young's modulus, ranging from compliant biological levels (~100 kPa) to stiffer structural polymers (~5 GPa). We use ligand exchange to tune filler-matrix interfaces, revealing that inverse sensor response scaling is maintained upon significant changes to polymer-tQD interface chemistry. We quantify and explore mechanisms of polymer-tQD strain transfer. An analytical model based on Mori-Tanaka theory presents agreement with observed trends. ...
Cloaking nanoparticles with protein corona shield for targeted drug delivery.
Nature Communications (IF 11.878) Pub Date : 2018-10-31 ,DOI:10.1038/s41467-018-06979-4
However, translating nanoparticle-based agents into clinical applications still remains a challenge due to the difficulty in regulating interactions on the interfaces between nanoparticles and biological systems. ...
Biological recognition of graphene nanoflakes.
Nature Communications (IF 11.878) Pub Date : 2018-04-20 ,DOI:10.1038/s41467-018-04009-x
The systematic study of nanoparticle-biological interactions requires particles to be reproducibly dispersed in relevant fluids along with further development in the identification of biologically relevant structural details at the materials-biology interface. ...
Carboxylic acid-modified metal oxide catalyst for selectivity-tunable aerobic ammoxidation.
Nature Communications (IF 11.878) Pub Date : 2018-03-02 ,DOI:10.1038/s41467-018-03358-x
Recent efforts to design chemoselective catalysts have focused on modifying the surface of metal nanoparticle materials having tunable properties. However, precise control over the surface properties of base-metal oxide catalysts remains a challenge. ...
Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer.
Nature Communications (IF 11.878) Pub Date : 2018-10-08 ,DOI:10.1038/s41467-018-06271-5
One of the impediments in nanoparticle-based tumor targeting is the inability to limit the trafficking of nanoparticles to liver and other organs leading to smaller accumulated amounts in tumor tissues, particularly via passive targeting. ...
Sustainable scalable synthesis of sulfide nanocrystals at low cost with an ionic liquid sulfur precursor.
Nature Communications (IF 11.878) Pub Date : 2018-10-04 ,DOI:10.1038/s41467-018-06549-8
We here show that H2S is stabilized by reaction with oleylamine (the most common and versatile ligand in nanoparticle synthesis) to form an ionic liquid precursor that addresses all major principles of green chemistry: it is made in one exothermic step, it leaves the reaction yielding a safer product ...
Post-polymerisation functionalisation of conjugated polymer backbones and its application in multi-functional emissive nanoparticles.
Nature Communications (IF 11.878) Pub Date : 2018-08-13 ,DOI:10.1038/s41467-018-05381-4
Backbone functionalisation of conjugated polymers is crucial to their performance in many applications, from electronic displays to nanoparticle biosensors, yet there are limited approaches to introduce functionality. ...
Single-site catalyst promoters accelerate metal-catalyzed nitroarene hydrogenation.
Nature Communications (IF 11.878) Pub Date : 2018-04-10 ,DOI:10.1038/s41467-018-03810-y
The promoters are single-site Sn on TiO2 supports that incorporate metal nanoparticle catalysts. Represented as M/Sn-TiO2 (M = Au, Ru, Pt, Ni), these catalysts decidedly outperform the unpromoted supported metals, even for hydrogenation of nitroarenes substituted with various reducible groups. ...
Nanowire arrays restore vision in blind mice.
Nature Communications (IF 11.878) Pub Date : 2018-03-06 ,DOI:10.1038/s41467-018-03212-0
Herein, inspired by the structure and function of photoreceptors in retinas, we develop artificial photoreceptors based on gold nanoparticle-decorated titania nanowire arrays, for restoration of visual responses in the blind mice with degenerated photoreceptors. ...
Observation of Tunable Charged Exciton Polaritons in Hybrid Monolayer WS2−Plasmonic Nanoantenna System
Nano Letters (IF 12.279) Pub Date : 2018-02-06 ,DOI:10.1021/acs.nanolett.7b04965
Our findings open up a possibility to exploit electrically charged polaritons at the single nanoparticlelevel. ...
Aluminum Nanorods
Nano Letters (IF 12.279) Pub Date : 2018-01-05 ,DOI:10.1021/acs.nanolett.7b04820
Al nanocrystals can be synthesized by high-temperature decomposition of triisobutyl aluminum, creating a mixture of nanoparticle geometries with a significant fraction (∼15%) being single-crystalline Al nanorods. ...
Deconvolution of octahedral Pt3Ni nanoparticle growth pathway from in situ characterizations.
Nature Communications (IF 11.878) Pub Date : 2018-10-26 ,DOI:10.1038/s41467-018-06900-z
Understanding the growth pathway of faceted alloy nanoparticles at the atomic level is crucial to morphology control and property tuning. Yet, it remains a challenge due to complexity of the growth process and technical limits of modern characterization tools. We report a combinational use of multiple cutting-edge in situ techniques to study the growth process of octahedral Pt3Ni nanoparticles, which reveal the particle growth and facet formation mechanisms. Our studies confirm the formation of octahedral Pt3Ni initiates from Pt nuclei generation, which is followed by continuous Pt reduction that simultaneously catalyzes Ni reduction, resulting in mixed alloy formation with moderate elemental segregation. Carbon monoxide molecules serve as a facet formation modulator and induce Ni segregation to the surface, which inhibits the (111) facet growth and causes the particle shape to evolve from a spherical cluster to an octahedron as the (001) facet continues to grow. ...
Non-fluorescent nanoscopic monitoring of a single trapped nanoparticle via nonlinear point sources.
Nature Communications (IF 11.878) Pub Date : 2018-06-07 ,DOI:10.1038/s41467-018-04689-5
Detection of single nanoparticles or molecules has often relied on fluorescent schemes. However, fluorescence detection approaches limit the range of investigable nanoparticles or molecules. Here, we propose and demonstrate a non-fluorescent nanoscopic trapping and monitoring platform that can trap a single sub-5-nm particle and monitor it with a pair of floating nonlinear point sources. The resonant photon funnelling into an extremely small volume of ~5 × 5 × 7 nm3 through the three-dimensionally tapered 5-nm-gap plasmonic nanoantenna enables the trapping of a 4-nm CdSe/ZnS quantum dot with low intensity of a 1560-nm continuous-wave laser, and the pumping of 1560-nm femtosecond laser pulses creates strong background-free second-harmonic point illumination sources at the two vertices of the nanoantenna. Under the stable trapping conditions, intermittent but intense nonlinear optical spikes are observed on top of the second-harmonic signal plateau, which is identified as the 3.0-Hz Kramers hopping of the quantum dot trapped in the 5-nm gap. ...
Three-Dimensional Decoupling Co-Catalyst from a Photoabsorbing Semiconductor as a New Strategy To Boost Photoelectrochemical Water Splitting
Nano Letters (IF 12.279) Pub Date : 2018-12-14 ,DOI:10.1021/acs.nanolett.8b04278
To demonstrate the concept, a facile method was developed for the in situ cogrowth of FeOx nanoparticles and conducting polymer (CP) network in various PAS with different microstructures such as a TiO2 nanorod array, WO3 nanosheet array, and planar TiO2 nanoparticle film, generating the bespoke photoanodes ...
Manipulating and monitoring nanoparticles in micellar thin film superstructures.
Nature Communications (IF 11.878) Pub Date : 2018-12-06 ,DOI:10.1038/s41467-018-07568-1
In particular, controlling the hierarchical organization of (macro)molecular and nanoparticle building blocks in monolayer superstructures is of paramount importance for tuning properties and characteristics. ...
MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma.
Nature Communications (IF 11.878) Pub Date : 2018-11-14 ,DOI:10.1038/s41467-018-07250-6
Our study offers a new strategy in targeted cancer theranostics through combining the merits of living cells and nanoparticle carriers. ...
Spontaneous formation of nanoparticles on electrospun nanofibres.
Nature Communications (IF 11.878) Pub Date : 2018-11-09 ,DOI:10.1038/s41467-018-07243-5
Indeed, solid acid fuel cells fabricated with electrodes from processed nanofibre-nanoparticlecomposites, produced higher cell voltage as compared to fuel cells fabricated with state-of-the-art electrodes. ...
Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models.
Nature Communications (IF 11.878) Pub Date : 2018-10-15 ,DOI:10.1038/s41467-018-06675-3
Combining live-cell nanoparticle tracking and super-resolution imaging, we show that AMPAR surface diffusion, a key player in synaptic plasticity, is disturbed in various rodent models of HD. ...
Strong coupling and induced transparency at room temperature with single quantum dots and gap plasmons.
Nature Communications (IF 11.878) Pub Date : 2018-10-01 ,DOI:10.1038/s41467-018-06450-4
Here we report measurements of scattering and photoluminescence from individual coupled plasmon-emitter systems that consist of a single colloidal quantum dot in the gap between a gold nanoparticleand a silver film. ...
Seed-mediated atomic-scale reconstruction of silver manganate nanoplates for oxygen reduction towards high-energy aluminum-air flow batteries.
Nature Communications (IF 11.878) Pub Date : 2018-09-13 ,DOI:10.1038/s41467-018-06211-3
Here, we show that silver nanoparticle-mediated silver manganate nanoplates are a highly active and chemically stable catalyst for oxygen reduction in alkaline media. ...
Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo.
Nature Communications (IF 11.878) Pub Date : 2018-08-17 ,DOI:10.1038/s41467-018-05641-3
Also, extending the 5' end of the crRNA by 59 nucleotides increases the delivery efficiency of Cpf1 RNP in cells and in vivo cationic delivery vehicles including polymer nanoparticle. ...
Nanoparticles Can Wrap Epithelial Cell Membranes and Relocate Them Across the Epithelial Cell Layer
Nano Letters (IF 12.279) Pub Date : 2018-07-26 ,DOI:10.1021/acs.nanolett.8b02291
Although the link between the inhalation of nanoparticles and cardiovascular disease is well established, the causal pathway between nanoparticle exposure and increased activity of blood coagulation factors remains unexplained. ...
Highly stable QLEDs with improved hole injection via quantum dot structure tailoring.
Nature Communications (IF 11.878) Pub Date : 2018-07-04 ,DOI:10.1038/s41467-018-04986-z
For the state-of-the-art quantum dot light-emitting diodes, while the ZnO nanoparticle layers can provide effective electron injections into quantum dots layers, the hole transporting materials usually cannot guarantee sufficient hole injection owing to the deep valence band of quantum dots. ...
Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering
Nature Nanotechnology (IF 33.407) Pub Date : 2018-04-30 ,DOI:10.1038/s41565-018-0113-3
This comprises monovalent TCR ligands anchored to lithographically patterned nanoparticle clusters surrounded by mobile adhesion molecules on a supported lipid bilayer. ...
Calcium-dependent molecular fMRI using a magnetic nanosensor
Nature Nanotechnology (IF 33.407) Pub Date : 2018-04-30 ,DOI:10.1038/s41565-018-0092-4
MaCaReNas thus provide a tool for calcium-activity mapping in deep tissue and offer a precedent for the development of further nanoparticle-based sensors for dynamic molecular imaging with MRI. ...
Modular assembly of proteins on nanoparticles.
Nature Communications (IF 11.878) Pub Date : 2018-04-16 ,DOI:10.1038/s41467-018-03931-4
Generally, the high diversity of protein properties necessitates the development of unique nanoparticlebio-conjugation methods, optimized for each different protein. ...
Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue.
Nature Communications (IF 11.878) Pub Date : 2018-03-05 ,DOI:10.1038/s41467-018-03208-w
Impaired conversion in diabetic wound tissue is rescued by targeted nanoparticle-based delivery of miR-21 to macrophages. This work introduces a paradigm wherein myeloid cells are recognized as a major source of fibroblast-like cells in the granulation tissue. ...
Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance.
Nature Communications (IF 11.878) Pub Date : 2018-02-08 ,DOI:10.1038/s41467-018-02915-8
Here, we report a lipid membrane-coated silica-carbon (LSC) hybrid nanoparticle that targets mitochondria through pyruvate, to specifically produce reactive oxygen species (ROS) in mitochondria under near-infrared (NIR) laser irradiation. ...
A general soft-enveloping strategy in the templating synthesis of mesoporous metal nanostructures.
Nature Communications (IF 11.878) Pub Date : 2018-02-06 ,DOI:10.1038/s41467-018-02930-9
Diverse monodispersed nanostructures with well-defined sizes and shapes, including Ag nanowires, 3D mesoporous Au, AuAg alloys, Pt networks, and Au nanoparticle superlattices are successfully obtained. ...
Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses.
Nature Communications (IF 11.878) Pub Date : 2018-01-24 ,DOI:10.1038/s41467-017-02725-4
Layered nanoparticles are fabricated by desolvating tetrameric M2e into protein nanoparticle cores and coating these cores by crosslinking headless HAs. Representative headless HAs of two HA phylogenetic groups are constructed and purified. ...
Sculpting nanoparticle dynamics for single-bacteria-level screening and direct binding-efficiency measurement.
Nature Communications (IF 11.878) Pub Date : 2018-02-26 ,DOI:10.1038/s41467-018-03156-5
Particle trapping and binding in optical potential wells provide a versatile platform for various biomedical applications. However, implementation systems to study multi-particle contact interactions in an optical lattice remain rare. By configuring an optofluidic lattice, we demonstrate the precise control of particle interactions and functions such as controlling aggregation and multi-hopping. The mean residence time of a single particle is found considerably reduced from 7 s, as predicted by Kramer's theory, to 0.6 s, owing to the mechanical interactions among aggregated particles. The optofluidic lattice also enables single-bacteria-level screening of biological binding agents such as antibodies through particle-enabled bacteria hopping. The binding efficiency of antibodies could be determined directly, selectively, quantitatively and efficiently. This work enriches the fundamental mechanisms of particle kinetics and offers new possibilities for probing and utilising unprecedented biomolecule interactions at single-bacteria level. ...
In situ formation of catalytically active graphene in ethylene photo-epoxidation.
Nature Communications (IF 11.878) Pub Date : 2018-08-03 ,DOI:10.1038/s41467-018-05352-9
Here, we use surface-enhanced Raman scattering to monitor the plasmon excitation-assisted reaction on individual sites of a Ag nanoparticle catalyst. We uncover an unconventional mechanism, wherein the primary step is the photosynthesis of graphene on the Ag surface. ...
Overcoming efficiency and stability limits in water-processing nanoparticular organic photovoltaics by minimizing microstructure defects.
Nature Communications (IF 11.878) Pub Date : 2018-12-17 ,DOI:10.1038/s41467-018-07807-5
This elegant approach opens an avenue that future organic photovoltaics processing may be indeed based on non-toxic water-based nanoparticle inks. ...
A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis.
Nature Communications (IF 11.878) Pub Date : 2018-11-28 ,DOI:10.1038/s41467-018-07197-8
Cancer cell membrane coating endows the nanoparticle with biological properties of homologous adhesion and immune escape. Thus, bio-NRs can effectively convert the glucose into 1O2 in metastatic tumors. ...
DNA-Assembled Plasmonic Waveguides for Nanoscale Light Propagation to a Fluorescent Nanodiamond
Nano Letters (IF 12.279) Pub Date : 2018-10-25 ,DOI:10.1021/acs.nanolett.8b03524
Plasmonic waveguides consisting of metal nanoparticle chains can localize and guide light well below the diffraction limit, but high propagation losses due to lithography-limited large interparticle spacing have impeded practical applications. ...
Modulating the hierarchical fibrous assembly of Au nanoparticles with atomic precision.
Nature Communications (IF 11.878) Pub Date : 2018-09-24 ,DOI:10.1038/s41467-018-06395-8
The ability to modulate nanoparticle (NP) assemblies with atomic precision is still lacking, which hinders us from creating hierarchical NP organizations with desired properties. ...
Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis
Nature Nanotechnology (IF 33.407) Pub Date : 2018-09-03 ,DOI:10.1038/s41565-018-0254-4
Here, we show a nanoparticle-based broad-spectrum anti-inflammatory strategy for rheumatoid arthritis management. ...
Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles.
Nature Communications (IF 11.878) Pub Date : 2018-05-18 ,DOI:10.1038/s41467-018-04315-4
To address these issues, we developed a transferrin-functionalized nanoparticle (Tf-NP) that can deliver dual combination therapies. ...
Light-driven transformable optical agent with adaptive functions for boosting cancer surgery outcomes.
Nature Communications (IF 11.878) Pub Date : 2018-05-10 ,DOI:10.1038/s41467-018-04222-8
Here, based on rational molecular design, we introduce a smart organic nanoparticle whose absorbed excitation energy can be photo-switched to the pathway of thermal deactivation for photoacoustic imaging, or to allow opposed routes for fluorescence imaging and photodynamic therapy. ...
Fourier Transform Surface Plasmon Resonance of Nanodisks Embedded in Magnetic Nanorods
Nano Letters (IF 12.279) Pub Date : 2018-02-12 ,DOI:10.1021/acs.nanolett.7b05439
We expect that our results will contribute to improved sensing module performance, as well as a better understanding of dynamic nanoparticle systems, by harnessing the perturbed periodic fluctuation of surface plasmon bands under the modulated magnetic field. ...
Giant photoeffect in proton transport through graphene membranes
Nature Nanotechnology (IF 33.407) Pub Date : 2018-01-22 ,DOI:10.1038/s41565-017-0051-5
Here we report that proton transport through Pt-nanoparticle-decorated graphene can be enhanced strongly by illuminating it with visible light. ...
Optical magnetism in planar metamaterial heterostructures.
Nature Communications (IF 11.878) Pub Date : 2018-01-18 ,DOI:10.1038/s41467-017-02589-8
Harnessing artificial optical magnetism has previously required complex two- and three-dimensional structures, such as nanoparticle arrays and split-ring metamaterials. ...
A Biomimetic Nanodecoy Traps Zika Virus To Prevent Viral Infection and Fetal Microcephaly Development
Nano Letters (IF 12.279) Pub Date : 2018-12-17 ,DOI:10.1021/acs.nanolett.8b03913
The ND, which is composed of a gelatin nanoparticle core camouflaged by mosquito medium host cell membranes, effectively adsorbs ZIKV and inhibits ZIKV replication in ZIKV-susceptible cells. ...
Active Targeting of Cancer Cells by Nanobody Decorated Polypeptide Micelle with Bio-orthogonally Conjugated Drug
Nano Letters (IF 12.279) Pub Date : 2018-12-14 ,DOI:10.1021/acs.nanolett.8b03837
We incorporate an unnatural amino acid, p-acetylphenylalanine, to provide a biorthogonal ketone for attachment of doxorubicin in the presence of reactive amino acids in a nanobody-targeted, elastin-like polypeptide nanoparticle. ...
Preclinical development of a microRNA-based therapy for intervertebral disc degeneration.
Nature Communications (IF 11.878) Pub Date : 2018-11-28 ,DOI:10.1038/s41467-018-07360-1
Therapeutically, upregulation or downregulation of miR-141 by nanoparticle delivery in IDD model aggravated or alleviated experimental IDD, respectively. Our findings reveal a novel mechanism by which miR-141, in part, promotes IDD progression by interacting with SIRT1/NF-κB pathway. ...
Liquid-state quantitative SERS analyzer on self-ordered metal liquid-like plasmonic arrays.
Nature Communications (IF 11.878) Pub Date : 2018-09-07 ,DOI:10.1038/s41467-018-05920-z
It paves the way toward a practical and quantitative liquid-state SERS analyzer, likened to a simple UV-Vis spectrometer, that is far superior to typical solid substrate-based or nanoparticle sol-based analysis. ...
Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment.
Nature Communications (IF 11.878) Pub Date : 2018-09-07 ,DOI:10.1038/s41467-018-06093-5
Here, we report the development of a dual size/charge- transformable, Trojan-Horse nanoparticle (pPhD NP) for delivery of ultra-small, full active pharmaceutical ingredients (API) nanotheranostics with integrated dual-modal imaging and trimodal therapeutic functions. pPhD NPs exhibit ideal size and charge ...
Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy.
Nature Communications (IF 11.878) Pub Date : 2018-07-04 ,DOI:10.1038/s41467-018-04763-y
This unique nanoparticle system may lead to potential approaches for bioorganic fluorescence-based delivering, imaging, and drug release tracking. ...
Quantifying compressive forces between living cell layers and within tissues using elastic round microgels.
Nature Communications (IF 11.878) Pub Date : 2018-05-14 ,DOI:10.1038/s41467-018-04245-1
Here we describe fluorescent nanoparticle-labeled, monodisperse elastic microspheres made of Arg-Gly-Asp-conjugated alginate hydrogels (elastic round microgels, ERMGs). We generate 3D displacements and calculate strains and tractions exerted on an ERMG. ...
Publisher Correction: Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer.
Nature Communications (IF 11.878) Pub Date : 2018-02-07 ,DOI:10.1038/s41467-018-02963-0
The original version of this Article contained an error in the spelling of the author Yingjie Yu, which was incorrectly given as Yu Yingjie. Furthermore, in Figure 3a, the labels 'MD | p < 0.05' incorrectly read 'MD | p > 0.05'. These errors have now been corrected in both the PDF and HTML versions of the Article. ...
Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity.
Nature Communications (IF 11.878) Pub Date : 2018-01-02 ,DOI:10.1038/s41467-017-02251-3
Immunostimulatory agents such as agonistic anti-CD137 and interleukin (IL)-2 generate effective anti-tumor immunity but also elicit serious toxicities, hampering their clinical application. Here we show that combination therapy with anti-CD137 and an IL-2-Fc fusion achieves significant initial anti-tumor activity, but also lethal immunotoxicity deriving from stimulation of circulating leukocytes. To overcome this toxicity, we demonstrate that anchoring IL-2 and anti-CD137 on the surface of liposomes allows these immune agonists to rapidly accumulate in tumors while lowering systemic exposure. In multiple tumor models, immunoliposome delivery achieves anti-tumor activity equivalent to free IL-2/anti-CD137 but with the complete absence of systemic toxicity. Immunoliposomes stimulated tumor infiltration by cytotoxic lymphocytes, cytokine production, and granzyme expression, demonstrating equivalent immunostimulatory effects to the free drugs in the local tumor microenvironment. Thus, surface-anchored particle delivery may provide a general approach to exploit the potent stimulatory activity of immune agonists without debilitating systemic toxicities. ...
Nanomechanical Plasmon Spectroscopy of Single Gold Nanoparticles
Nano Letters (IF 12.279) Pub Date : 2018-10-19 ,DOI:10.1021/acs.nanolett.8b03236
We experimentally demonstrate the effect of the localized surface plasmon resonance (LSPR) of a single gold nanoparticle (AuNP) of 100 nm in diameter on the mechanical resonance frequency of a free-standing silicon nitride membrane by means of optomechanical transduction. ...
Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies.
Nature Communications (IF 11.878) Pub Date : 2018-10-04 ,DOI:10.1038/s41467-018-06602-6
Many nanoparticle (NP)-based drug delivery systems are also actively investigated, but their advantage over ADCs has not been demonstrated yet. ...
A cocoon silk chemistry strategy to ultrathin N-doped carbon nanosheet with metal single-site catalysts.
Nature Communications (IF 11.878) Pub Date : 2018-09-21 ,DOI:10.1038/s41467-018-06296-w
In particular, the Co-ISA/CNS exhibit ultrahigh specific surface area (2105 m2 g-1) and high activity for C-H bond activation in the direct catalytic oxidation of benzene to phenol with hydrogen peroxide at room temperature, while the Co species in the form of phthalocyanine and metal nanoparticle show ...
Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity.
Nature Communications (IF 11.878) Pub Date : 2018-07-31 ,DOI:10.1038/s41467-018-05342-x
Ferumoxytol is a nanoparticle formulation approved by the U.S. Food and Drug Administration for systemic use to treat iron deficiency. Here, we show that, in addition, ferumoxytol disrupts intractable oral biofilms and prevents tooth decay (dental caries) via intrinsic peroxidase-like activity. ...
Synthesis of Patient-Specific Nanomaterials
Nano Letters (IF 12.279) Pub Date : 2018-12-28 ,DOI:10.1021/acs.nanolett.8b03434
Finally, we demonstrate that PNPs created from different human patients have unique molecular fingerprints encoded directly into the structure of the nanoparticle. ...
Self-Folding Hybrid Graphene Skin for 3D Biosensing
Nano Letters (IF 12.279) Pub Date : 2018-11-19 ,DOI:10.1021/acs.nanolett.8b03461
Our platform features an ultrathin thermally responsive poly(N-isopropylacrylamide)-graphene-nanoparticle hybrid skin that can be triggered to self-fold and wrap around 3D micro-objects in a conformal manner due to its superior flexibility. ...
Lifetime-engineered NIR-II nanoparticles unlock multiplexed in vivo imaging
Nature Nanotechnology (IF 33.407) Pub Date : 2018-08-06 ,DOI:10.1038/s41565-018-0221-0
We consistently resolve selected lifetimes from the NIR-II nanoparticle probes at depths of up to 8 mm in biological tissues, where the signal-to-noise ratio derived from intensity measurements drops below 1.5. ...
Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap.
Nature Communications (IF 11.878) Pub Date : 2018-06-08 ,DOI:10.1038/s41467-018-04605-x
By design of a PD-L1 trap and loading its coding plasmid DNA into a lipid-protamine-DNA nanoparticle, PD-L1 trap is produced transiently and locally in the tumor microenvironment, and synergizes with OxP for tumor inhibition. ...
Current Strategies for Brain Drug Delivery
Theranostics (IF 8.063) Pub Date : 2018-02-05 ,DOI:10.7150/thno.21254
Current non-nanoparticle strategies are also reviewed, such as delivery of drugs through the permeable BBB under pathological conditions and using non-invasive techniques to enhance brain drug uptake. ...
Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape
Nano Letters (IF 12.279) Pub Date : 2018-05-22 ,DOI:10.1021/acs.nanolett.8b00660
Structural DNA nanotechnology has an unparalleled ability to self-assemble three-dimensional nanostructures with near-atomic resolution features, and thus, it offers an attractive platform for the systematic exploration of the parameter space relevant to nanoparticle uptake by living cells. ...
Acoustic Mode Hybridizationin a Single Dimer of Gold Nanoparticles
Nano Letters (IF 12.279) Pub Date : 2018-05-03 ,DOI:10.1021/acs.nanolett.8b01072
Such coupling induces the hybridization of the vibrational modes of each nanoparticle, leading to the appearance in the Raman spectra of two ultralow-frequency modes corresponding to the out-of-phase longitudinal and transverse (with respect to the dimer axis) quasi-translations of the nanoparticles. ...
Potency of a Scalable Nanoparticulate Subunit Vaccine
Nano Letters (IF 12.279) Pub Date : 2018-04-30 ,DOI:10.1021/acs.nanolett.8b00478
This approach may benefit from a nanoparticle engineering method with fine control over size and codelivery of antigen and adjuvant. ...
A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation
Nano Letters (IF 12.279) Pub Date : 2018-03-05 ,DOI:10.1021/acs.nanolett.8b00432
These data demonstrate that barcoded LNPs can elucidate fundamental questions about in vivo nanoparticle delivery. ...
Lewis basicity generated by localised charge imbalance in noble metal nanoparticle-embedded defective metal-organic frameworks.
Nature Communications (IF 11.878) Pub Date : 2018-10-18 ,DOI:10.1038/s41467-018-06828-4
Interactions between metal nanoparticles (NPs) and metal-organic frameworks (MOFs) in their composite forms have proven to exhibit beneficial properties, such as enhanced catalytic performance through synergistic effects. Herein, we show that Lewis basic sites can be created within an anionic defective MOF by engineering the electronic state of the pendant carboxylate groups situated at the defect sites. This is achieved from the concerted interactions between the pendant carboxylate groups, embedded Pd NPs and charge-balancing cations (Mn+ = Ce3+, Co2+, Ni2+, Cu2+, Mg2+, Li+, Na+ or K+). This work is the first example of generating a new collective property, i.e. Lewis basicity, in metal-carboxylate MOFs. Importantly, the choice of Mn+, used during cation exchange, acts as a convenient parameter to tune the Lewis basicity of the MOF-based nanocomposites. It also provides a facile way to incorporate active metal sites and basic sites within carboxylate-based MOFs to engineer multifunctional nanocatalysts. ...
Gelatin Nanoparticle-Coated Silicon Beads for Density-Selective Capture and Release of Heterogeneous Circulating Tumor Cells with High Purity
Theranostics (IF 8.063) Pub Date : 2018-02-07 ,DOI:10.7150/thno.23531
Background: Circulating tumor cells (CTCs) are a burgeoning topic in cancer biomarker discovery research with minimal invasive blood draws. CTCs can be used as potential biomarkers for disease prognosis, early cancer diagnosis and pharmacodynamics. However, the extremely low abundance of CTCs limits their clinical utility because of technical challenges such as the isolation and subsequent detailed molecular and functional characterization of rare CTCs from patient blood samples. ...
Circulating ectosomes: Determination of angiogenic microRNAs in type 2 diabetes.
Theranostics (IF 8.063) Pub Date : 2018-08-08 ,DOI:10.7150/thno.23334
Methods: We used different approaches for detecting and enumerating Ects, including atomic force microscopy, cryogenic transmission electron microscopy, and nanoparticle tracking analysis. ...
Near-Infrared Afterglow Luminescent Aggregation-Induced Emission Dots with Ultrahigh Tumor-to-Liver Signal Ratio for Promoted Image-Guided Cancer Surgery
Nano Letters (IF 12.279) Pub Date : 2018-12-17 ,DOI:10.1021/acs.nanolett.8b03936
Here, we design and synthesize a NIR afterglow luminescent nanoparticle with aggregation-induced emission (AIE) characteristics (named AGL AIE dots). ...
Three-Dimensional Quantification of the Facet Evolution of Pt Nanoparticles in a Variable Gaseous Environment
Nano Letters (IF 12.279) Pub Date : 2018-12-14 ,DOI:10.1021/acs.nanolett.8b04303
High-resolution electron microscopy has often been used to characterize nanoparticle catalysts but unfortunately most observations so far have been either performed in vacuum and/or using conventional (2D) in situ microscopy. The latter however does not provide direct 3D morphological information. ...
Controlling Reaction Selectivity over Hybrid Plasmonic Nanocatalysts
Nano Letters (IF 12.279) Pub Date : 2018-10-26 ,DOI:10.1021/acs.nanolett.8b03499
We have found that the localized interaction between the triple bond in phenylacetylene and the Pt nanoparticle surface enables selective hydrogenation of the triple bond (relative to the double bond in styrene) under visible light illumination. ...
Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases.
Nature Communications (IF 11.878) Pub Date : 2018-10-05 ,DOI:10.1038/s41467-018-06522-5
In this study, we screen an optimized cationic lipid-assisted nanoparticle (CLAN) to deliver Cas9 mRNA (mCas9) and guide RNA (gRNA) into macrophages. ...
Enhanced water splitting under modal strong coupling conditions
Nature Nanotechnology (IF 33.407) Pub Date : 2018-07-30 ,DOI:10.1038/s41565-018-0208-x
We use a gold nanoparticle (Au-NP)/TiO2/Au-film structure as a photoanode. This structure exhibits modal strong coupling between the Fabry–Pérot nanocavity modes of the TiO2 thin film/Au film and LSPR of the Au NPs. ...
TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis.
Nature Communications (IF 11.878) Pub Date : 2018-05-18 ,DOI:10.1038/s41467-018-04460-w
Here, we show that nanoparticle-mediated delivery of transforming growth factor-β1-activated kinase-1 (TAK1) inhibitor 5Z-7-Oxozeaenol can inhibit TNBC lung metastasis in most animals tested. P38 is a central signal downstream of TAK1 in TNBC cells in TAK1-mediated response to multiple cytokines. ...
Dynamics of the Optically Directed Assembly and Disassembly of Gold Nanoplatelet Arrays
Nano Letters (IF 12.279) Pub Date : 2018-05-21 ,DOI:10.1021/acs.nanolett.8b00199
One approach involves nanoparticle-based optical matter, but so far, studies have only considered spherical constituents. ...
Smart Nanoreactors for pH-Responsive Tumor Homing, Mitochondria-Targeting, and Enhanced Photodynamic-Immunotherapy of Cancer
Nano Letters (IF 12.279) Pub Date : 2018-03-26 ,DOI:10.1021/acs.nanolett.8b00040
Moreover, by combining our nanoparticle-based PDT with check-point-blockade therapy, systemic antitumor immune responses could be achieved to kill nonirradiated tumors 1–2 cm away, promising for metastasis inhibition. ...
Position Accuracy of Gold Nanoparticles on DNA Origami Structures Studied with Small-Angle X-ray Scattering
Nano Letters (IF 12.279) Pub Date : 2018-03-06 ,DOI:10.1021/acs.nanolett.8b00412
Here, we show that the pair density distribution function (PDDF) obtained from an indirect Fourier transform of SAXS intensities in a model-free way allows to investigate prototypical DNA origami-mediated gold nanoparticle (AuNP) assemblies. ...
Wavelength-Dependent Optical Force Imaging of Bimetallic Al–Au Heterodimers
Nano Letters (IF 12.279) Pub Date : 2018-02-15 ,DOI:10.1021/acs.nanolett.8b00020
Understanding the correlations between nanoparticle morphology and near-field optical properties, particularly for nanostructures composed of two different metals, requires spectrally resolved near-field spatial information. ...
Coherent Discriminatory Modal Manipulation of Acoustic Phonons at the Nanoscale
Nano Letters (IF 12.279) Pub Date : 2018-01-09 ,DOI:10.1021/acs.nanolett.7b04662
In particular, we use an Au–Ag core–shell nanoparticle with a manifestation of multiple phonon vibrational modes as a model system for multimodal-phonon manipulation, and we demonstrate that the simple addition of a femtosecond optical control pulse to an all-optical pump–probe phonon measurement can ...
A hook effect-free immunochromatographic assay (HEF-ICA) for measuring the C-reactive protein concentration in one drop of human serum.
Theranostics (IF 8.063) Pub Date : 2018-06-23 ,DOI:10.7150/thno.24034
To reduce the potential occurrence of this simultaneous reaction, we separated the migration of the target antigen and gold nanoparticle (AuNP)-labeled antibodies on a nitrocellulose membrane and analyzed the time profiles by modifying the ICA structure. ...
Tumor-targeted hybrid protein oxygen carrier to simultaneously enhance hypoxia-dampened chemotherapy and photodynamic therapy at a single dose.
Theranostics (IF 8.063) Pub Date : 2018-07-22 ,DOI:10.7150/thno.25409
The combination therapy was guided by in vivo fluorescence/photoacoustic imaging with nanoparticletracking and oxygen monitoring. ...
Personalized Nanotherapy by Specifically Targeting Cell Organelles To Improve Vascular Hypertension
Nano Letters (IF 12.279) Pub Date : 2018-12-26 ,DOI:10.1021/acs.nanolett.8b04138
Therefore, we generated and compared two different (metal and polymer) cilia-targeted nanoparticledrug delivery systems (CTNDDS), CT-DAu-NPs and CT-PLGA-NPs, for the first time. These CTNDDS loaded with fenoldopam were further compared to fenoldopam-alone. ...
Collective Strong Light-Matter Coupling in Hierarchical Microcavity-Plasmon-Exciton Systems
Nano Letters (IF 12.279) Pub Date : 2018-12-07 ,DOI:10.1021/acs.nanolett.8b03639
By intermixing plasmonic excitations in nanoparticle arrays with excitons in a WS2 monolayer inside a resonant metallic microcavity, we fabricate a hierarchical system with the collective microcavity–plasmon–exciton Rabi splitting exceeding ∼500 meV at room temperature. ...
Favorable Core/Shell Interface within Co2P/Pt Nanorods for Oxygen Reduction Electrocatalysis
Nano Letters (IF 12.279) Pub Date : 2018-11-19 ,DOI:10.1021/acs.nanolett.8b03666
The resultant Co2P/Pt NRs are highly efficient in catalyzing ORR in acid, superior to benchmark CoPt alloy and Pt nanoparticle catalyst. ...
Unique Photochemo-Immuno-Nanoplatform against Orthotopic Xenograft Oral Cancer and Metastatic Syngeneic Breast Cancer
Nano Letters (IF 12.279) Pub Date : 2018-10-26 ,DOI:10.1021/acs.nanolett.8b03096
The coassembled nanoparticle (CPCI-NP) possesses superior photothermal conversion efficiency as well as efficient encapsulation and controlled release of cytotoxic molecules and immunomodulatory agents. ...
Strong Light–Matter Coupling between Plasmons in Individual Gold Bi-pyramids and Excitons in Mono- and Multilayer WSe2
Nano Letters (IF 12.279) Pub Date : 2018-08-13 ,DOI:10.1021/acs.nanolett.8b02652
However, standard plasmonic nanoantenna designs such as nanoparticle dimers or particle-on-film suffer from misalignment of the local electric field in the gap with the in-plane transition dipole moment of monolayer TMDCs. ...
Stable, Ultralow Threshold Amplified Spontaneous Emission from CsPbBr3 Nanoparticles Exhibiting Trion Gain
Nano Letters (IF 12.279) Pub Date : 2018-07-20 ,DOI:10.1021/acs.nanolett.8b01817
We then show that, in line with theoretical prediction, the amplified spontaneous emission (ASE) threshold of a thin film of surface-treated CsPbBr3 nanoparticles reduces to a record low of ∼1.2 μJ/cm2 with a corresponding average exciton occupancy per nanoparticle of 0.62. ...
Therapeutic Efficacy-Potentiated and Diseased Organ-Targeting Nanovesicles Derived from Mesenchymal Stem Cells for Spinal Cord Injury Treatment
Nano Letters (IF 12.279) Pub Date : 2018-07-13 ,DOI:10.1021/acs.nanolett.8b01816
Therefore, in this study we fabricated iron oxide nanoparticle (IONP)–incorporated exosome-mimetic nanovesicles (NV-IONP) from IONP-treated hMSCs and evaluated their therapeutic efficacy in a clinically relevant model for spinal cord injury. ...
Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance
Nano Letters (IF 12.279) Pub Date : 2018-06-19 ,DOI:10.1021/acs.nanolett.8b01924
The construction of a unique nanoparticle (NP) platform composed of poly(disulfide amide) polymers with a high disulfide density for the effective delivery of Pt(IV) prodrugs capable of reversing cisplatin resistance through the disulfide-group-based GSH-scavenging process, as described herein, is a ...
Photoinduced Tip–Sample Forces for Chemical Nanoimaging and Spectroscopy
Nano Letters (IF 12.279) Pub Date : 2018-08-14 ,DOI:10.1021/acs.nanolett.8b01899
Control of photoinduced forces allows nanoparticle manipulation, atom trapping, and fundamental studies of light-matter interactions. ...
Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy
Nano Letters (IF 12.279) Pub Date : 2018-04-26 ,DOI:10.1021/acs.nanolett.8b01071
Herein, a therapeutic peptide assembling nanoparticle that can sequentially respond to dual stimuli in the tumor extracellular matrix was designed for tumor-targeted delivery and on-demand release of a short d-peptide antagonist of programmed cell death-ligand 1 (DPPA-1) and an inhibitor of idoleamine ...
Powerful anti-colon cancer effect of modified nanoparticle-mediated IL-15 immunogene therapy through activation of the host immune system.
Theranostics (IF 8.063) Pub Date : 2018-07-22 ,DOI:10.7150/thno.24157
Rationale: Colorectal cancer (CRC) is the third most commonly diagnosed cancer around the world. Over the past several years, immunotherapy has demonstrated considerable clinical benefit in CRC therapy, and the number of immunologic therapies for cancer treatment continues to climb each year. Interleukin-15 (IL15), a potent pro-inflammatory cytokine, has emerged as a candidate immunomodulator for the treatment of CRC. Methods: In this study, we developed a novel gene delivery system with a self-assembly method using DOTAP and MPEG-PLA (DMA) to carry pIL15, denoted as DMA-pIL15 which was used to treat tumor-bearing mice. Results: Supernatant from lymphocytes treated with supernatant derived from CT26 cells transfected with DMA-pIL15 inhibited the growth of CT26 cells and induced cell apoptosis in vitro. Treatment of tumor-bearing mice with DMA-pIL15 complex significantly inhibited tumor growth in both subcutaneous and peritoneal models in vivo by inhibiting angiogenesis, promoting apoptosis, and reducing proliferation through activation of the host immune system. Conclusion: The IL-15 plasmid and DMA complex showed promise for treating CRC clinically as an experimental new drug. ...
Harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer.
Nature Communications (IF 11.878) Pub Date : 2018-10-12 ,DOI:10.1038/s41467-018-06529-y
Chemo-PTT, which combines chemotherapy with photothermal therapy, offers a viable approach for the complete tumor eradication but would likely fail in drug-resistant situations if conventional chemotherapeutic agents are used. Here we show that a type of copper (Cu)-palladium (Pd) alloy tetrapod nanoparticles (TNP-1) presents an ideal solution to the chemo-PTT challenges. TNP-1 exhibit superior near-infrared photothermal conversion efficiency, thanks to their special sharp-tip structure, and induce pro-survival autophagy in a shape- and composition-dependent manner. Inhibition of autophagy with 3-methyl adenine or chloroquine has a remarkable synergistic effect on TNP-1-mediated PTT in triple-negative (4T1), drug-resistant (MCF7/MDR) and patient-derived breast cancer models, achieving a level of efficacy unattainable with TNP-2, the identically-shaped CuPd nanoparticles that have a higher photothermal conversion efficiency but no autophagy-inducing activity. Our results provide a proof-of-concept for a chemo-PTT strategy, which utilizes autophagy inhibitors instead of traditional chemotherapeutic agents and is particularly useful for eradicating drug-resistant cancer. ...
Ordered Pt3Co Intermetallic Nanoparticles Derived from Metal–Organic Frameworks for Oxygen Reduction
Nano Letters (IF 12.279) Pub Date : 2018-06-11 ,DOI:10.1021/acs.nanolett.8b00978
The optimal Pt3Co nanoparticle catalyst has achieved significantly enhanced activity and stability, exhibiting a half-wave potential up to 0.92 V vs reversible hydrogen electrode (RHE) and only losing 12 mV after 30 000 potential cycling between 0.6 and 1.0 V. ...
An Adenosine Triphosphate-Responsive Autocatalytic Fenton Nanoparticle for Tumor Ablation with Self-Supplied H2O2 and Acceleration of Fe(III)/Fe(II) Conversion
Nano Letters (IF 12.279) Pub Date : 2018-11-07 ,DOI:10.1021/acs.nanolett.8b03178
Chemodynamic therapy (CDT) can efficiently destroy tumor cells via Fenton reaction in the presence of H2O2 and a robust catalyst. However, it has faced severe challenges including the limited amounts of H2O2 and inefficiency of catalysts. Here, an adenosine triphosphate (ATP)-responsive autocatalytic Fenton nanosystem (GOx@ZIF@MPN), incorporated with glucose oxidase (GOx) in zeolitic imidazolate framework (ZIF) and then coated with metal polyphenol network (MPN), was designed and synthesized for tumor ablation with self-supplied H2O2 and TA-mediated acceleration of Fe(III)/Fe(II) conversion. In the ATP-overexpressed tumor cells, the outer shell MPN of GOx@ZIF@MPN was degraded into Fe(III) and tannic acid (TA) and the internal GOx was exposed. Then, GOx reacted with the endogenous glucose to produce plenty of H2O2, and TA reduced Fe(III) to Fe(II), which is a much more vigorous catalyst for the Fenton reaction. Subsequently, self-produced H2O2 was catalyzed by Fe(II) to generate highly toxic hydroxyl radical (•OH) and Fe(III). The produced Fe(III) with low catalytic activity was quickly reduced to reactive Fe(II) mediated by TA, forming an accelerated Fe(III)/Fe(II) conversion to guarantee efficient Fenton reaction-mediated CDT. This autocatalytic Fenton nanosystem might provide a good paradigm for effective tumor treatment. ...
Self-assembled dual fluorescence nanoparticles for CD44-targeted delivery of anti-miR-27a in liver cancer theranostics.
Theranostics (IF 8.063) Pub Date : 2018-08-08 ,DOI:10.7150/thno.25255
Herein, a multifunctional nanoparticle for noninvasive tracking of targeted delivery of anti-miR-27a oligonucleotides against liver cancer was constructed. ...
Self-assembly of Janus Dumbbell Nanocrystals and Their Enhanced Surface Plasmon Resonance
Nano Letters (IF 12.279) Pub Date : 2018-12-31 ,DOI:10.1021/acs.nanolett.8b04464
Self-assembly is a critical process that can greatly expand the existing structures and lead to new functionality of nanoparticle systems. Multicomponent superstructures self-assembled from nanocrystals have shown promise as multifunctional materials for various applications. ...
MMP1/PAR1/SP/NK1R paracrine loop modulates early perineural invasion of pancreatic cancer cells.
Theranostics (IF 8.063) Pub Date : 2018-06-14 ,DOI:10.7150/thno.24281
PNI was assessed by MRI with iron oxide nanoparticle labeling. We searched publicly available datasets as well as obtained PDAC tissues from 30 patients to examine MMP1 expression in human tumor and non-tumor tissues. ...
Exosomal microRNA-21 derived from bronchial epithelial cells is involved in aberrant epithelium-fibroblast cross-talk in COPD induced by cigarette smoking
Theranostics (IF 8.063) Pub Date : 2018-10-29 ,DOI:10.7150/thno.27876
The size distribution and concentration of exosomes were analyzed by nanoparticle tracking analysis using a ZetaView particle tracker from ParticleMetrix. ...
Multimodal imaging of the receptor for advanced glycation end-products with molecularly targeted nanoparticles
Theranostics (IF 8.063) Pub Date : 2018-10-05 ,DOI:10.7150/thno.24791
Therefore, we have developed a multimodal nanoparticle-based imaging agent targeted at RAGE with the well-characterized RAGE ligand, carboxymethyllysine (CML)-modified human serum albumin (HSA). ...
Blood exosomes regulate the tissue distribution of grapefruit-derived nanovector via CD36 and IGFR1 pathways
Theranostics (IF 8.063) Pub Date : 2018-09-09 ,DOI:10.7150/thno.27608
Exosomes, a type of endogenous nanoparticle, circulate continuously in the peripheral blood and play a role in intercellular communication. The aim of this study was to determine whether the level of endogenous exosomes has an effect on nanovector delivery efficiency of targeted agents. ...
Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19.
Theranostics (IF 8.063) Pub Date : 2018-08-08 ,DOI:10.7150/thno.25541
Isolated exosomes were identified by transmission electron microscopy, nanoparticle tracking and Western blotting. Results: H19 was highly expressed in the tumor tissues of CAC mice compared with the expression in normal colon tissues. ...
Anti-tumor macrophages activated by ferumoxytol combined or surface-functionalized with the TLR3 agonist poly (I : C) promote melanoma regression
Theranostics (IF 8.063) Pub Date : 2018-11-29 ,DOI:10.7150/thno.29746
Ferumoxytol (FMT), a clinically approved iron oxide nanoparticle, possesses anti-tumor therapeutic potential by inducing pro-inflammatory macrophage polarization. Toll-like receptor 3 (TLR3) activation also potently enhances the anti-tumor response of immune cells. ...
Verification of Long-Term Genetic Stability of hMSCs during Subculture after Internalization of Sunflower-Type Nanoparticles (SF-NPs)
Theranostics (IF 8.063) Pub Date : 2018-11-05 ,DOI:10.7150/thno.29214
Keywords: quantum dot, Sunflower-type nanoparticle, genomic stability, single-nucleotide polymorphism, karyotyping, mRNA/DNA profile ...
Therapeutic Fluorescent Hybrid Nanoparticles for Traceable Delivery of Glucocorticoids to Inflammatory Sites
Theranostics (IF 8.063) Pub Date : 2018-12-07 ,DOI:10.7150/thno.28324
Keywords: hybrid nanoparticles, nanoparticle-based therapy, inflammatory disease, monitoring glucocorticoid delivery, in vivo imaging ...
Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake
ACS Nano (IF 13.903) Pub Date : 2018-01-18 ,DOI:10.1021/acsnano.7b06995
To achieve effective cell-specific targeting of drugs through nanoparticle encapsulation, improved mechanistic understanding of nanoparticle–liver interactions is required. ...
Materials by Design for Stiff and Tough Hairy Nanoparticle Assemblies
ACS Nano (IF 13.903) Pub Date : 2018-07-05 ,DOI:10.1021/acsnano.8b02454
size and the polymer-nanoparticle interfacial interactions. ...
Tumor-Vasculature-on-a-Chip for Investigating Nanoparticle Extravasation and Tumor Accumulation
ACS Nano (IF 13.903) Pub Date : 2018-11-05 ,DOI:10.1021/acsnano.8b06846
Nanoparticle tumor accumulation relies on a key mechanism, the enhanced permeability and retention (EPR) effect, but it remains challenging to decipher the exact impact of the EPR effect. ...
Evolution of Nanoparticle Protein Corona across the Blood–Brain Barrier
ACS Nano (IF 13.903) Pub Date : 2018-07-02 ,DOI:10.1021/acsnano.8b03500
Thus, we demonstrate that the nanoparticle corona dynamically and drastically evolves upon crossing the BBB and that its initial composition is not predictive of nanoparticle fate and performance once beyond the barrier at the target organ. ...
Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers
ACS Nano (IF 13.903) Pub Date : 2018-03-20 ,DOI:10.1021/acsnano.7b08620
Here we combine recent advances in DNA-gold nanoparticle self-assembly and sensing to develop gold nanoparticle dimers that are able to perform multiplexed synergistic functions within a cellular environment. ...
Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumors
ACS Nano (IF 13.903) Pub Date : 2018-07-26 ,DOI:10.1021/acsnano.8b03900
Coating the nanoparticle surface with cancer cell recognizing ligands is expected to facilitate specific delivery of nanoparticles to diseased cells in vivo. ...
Programming Nanoparticles in Multiscale: Optically Modulated Assembly and Phase Switching of Silicon Nanoparticle Array
ACS Nano (IF 13.903) Pub Date : 2018-02-26 ,DOI:10.1021/acsnano.8b00198
We report scalable, direct, and optically modulated writing of nanoparticle patterns (size, number, and location) of high precision using a pulsed nanosecond laser. ...
Tracking Metal Electrodeposition Dynamics from Nucleation and Growth of a Single Atom to a Crystalline Nanoparticle
ACS Nano (IF 13.903) Pub Date : 2018-07-13 ,DOI:10.1021/acsnano.8b04089
In doing so, we reveal the importance of electrochemically driven atom transport, atom cluster formation, cluster progression to a nanoparticle, and the mechanism by which neighboring particles interact during growth. ...
High-Resolution Large-Ensemble Nanoparticle Trapping with Multifunctional Thermoplasmonic Nanohole Metasurface
ACS Nano (IF 13.903) Pub Date : 2018-06-07 ,DOI:10.1021/acsnano.8b00318
Using plasmonic loss to our advantage, we introduce a thermoplasmonic metasurface that enables high-throughput large-ensemble nanoparticle assembly in a lab-on-a-chip platform. ...
Quantifying Photothermal and Hot Charge Carrier Effects in Plasmon-Driven Nanoparticle Syntheses
ACS Nano (IF 13.903) Pub Date : 2018-08-02 ,DOI:10.1021/acsnano.8b03929
We find that non-thermal effects can be dominant and their relative contribution depends on the fraction of nanoparticle suspension under irradiation. ...
Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery
ACS Nano (IF 13.903) Pub Date : 2018-07-20 ,DOI:10.1021/acsnano.8b03640
RNA delivery can be improved by rationally selecting cholesterol variants, allowing optimization of nanoparticle targeting. ...
Peptide-Programmable Nanoparticle Superstructures with Tailored Electrocatalytic Activity
ACS Nano (IF 13.903) Pub Date : 2018-06-04 ,DOI:10.1021/acsnano.8b01146
Here, we present programmed superstructures of AuPt nanoparticles (NPs) on carbon nanotubes (CNTs) that exhibit distinct electrocatalytic activities with respect to the nanoparticle positions via rationally modulated peptide-mediated assembly. ...
Routes to Potentially Safer T1 Magnetic Resonance Imaging Contrast in a Compact Plasmonic Nanoparticle with Enhanced Fluorescence
ACS Nano (IF 13.903) Pub Date : 2018-08-16 ,DOI:10.1021/acsnano.8b03368
This dual-modality nanostructure can enable not only tissue visualization with MRI but also fluorescence-based nanoparticle tracking for quantifying nanoparticle distributions in vivo, in addition to a near-infrared photothermal therapeutic response. ...
Mechanistic Understanding of the Growth Kinetics and Dynamics of Nanoparticle Superlattices by Coupling Interparticle Forces from Real-Time Measurements
ACS Nano (IF 13.903) Pub Date : 2018-11-16 ,DOI:10.1021/acsnano.8b07880
Our study provides a fundamental understanding of coupling energetics and dynamics of NPs involved in the assembly process, enabling the control and design of the structure of nanoparticle superlattices. ...
In Vivo Bioimaging of Silver Nanoparticle Dissolution in the Gut Environment of Zooplankton
ACS Nano (IF 13.903) Pub Date : 2018-11-26 ,DOI:10.1021/acsnano.8b06003
Release of silver ions (Ag+) is often regarded as the major cause for silver nanoparticle (AgNP) toxicity toward aquatic organisms. ...
Understanding the Interplay between Self-Assembling Peptides and Solution Ions for Tunable Protein Nanoparticle Formation
ACS Nano (IF 13.903) Pub Date : 2018-06-28 ,DOI:10.1021/acsnano.8b02381
We further demonstrate that the two independent factors of pH and Mg2+ ions can be combined to regulate nanoparticle size. ...
Synthesis of Self-Assembled Porphyrin Nanoparticle Photosensitizers
ACS Nano (IF 13.903) Pub Date : 2018-04-11 ,DOI:10.1021/acsnano.8b01010
In this paper, we report a synthesis of self-assembled porphyrin nanoparticle photosensitizers using zinc meso-tetra(4-pyridyl)porphyrin (ZnTPyP) through a confined noncovalent self-assembly process. Scanning electron microscopy reveals formation of monodisperse cubic nanoparticles. ...
Enhancing Coupled Enzymatic Activity by Colocalization on Nanoparticle Surfaces: Kinetic Evidence for Directed Channeling of Intermediates
ACS Nano (IF 13.903) Pub Date : 2018-07-25 ,DOI:10.1021/acsnano.8b02334
Here, we investigate the effects of displaying two enzymes with coupled catalytic activity directly on the same nanoparticle surface. ...
Fundamental Limits of Optical Tweezer Nanoparticle Manipulation Speeds
ACS Nano (IF 13.903) Pub Date : 2018-02-08 ,DOI:10.1021/acsnano.7b07914
In contrast, we push nanoparticle manipulation beyond the region in which maximum lateral movement speed is linearly proportional to laser power, and investigate the fundamental limits imposed by material absorption, thus quantifying maximum possible speeds attainable with optical tweezers. ...
A Gold Nanoparticle Bio-Optical Transponder to Dynamically Monitor Intracellular pH
ACS Nano (IF 13.903) Pub Date : 2018-06-13 ,DOI:10.1021/acsnano.8b02200
A pH-sensitive bio-optical transponder (pH-BOT) capable of simultaneously reporting the timing of intracellular DNA cargo release from a gold nanoparticle (AuNP) and the evolving intracellular pH (pHi) during endosomal maturation is demonstrated. ...
Ultrasmall Plasmonic Single Nanoparticle Light Source Driven by a Graphene Tunnel Junction
ACS Nano (IF 13.903) Pub Date : 2018-03-14 ,DOI:10.1021/acsnano.7b09163
The monolayer graphene provides a transparent counter electrode for tunneling while preserving the ultrasmall footprint and plasmonic mode of nanoparticle. The tunneling electrons excite the plasmonic mode, followed by radiative decay of the plasmon. ...
Watching Visible Light-Driven CO2 Reduction on a Plasmonic Nanoparticle Catalyst
ACS Nano (IF 13.903) Pub Date : 2018-08-13 ,DOI:10.1021/acsnano.8b03617
Here, we probe with single-nanoparticle spatial resolution the dynamics of a plasmonic silver (Ag) photocatalyst under conditions of visible light-driven CO2 reduction. ...
Coating Metal Nanoparticle Surfaces with Small Organic Molecules Can Reduce Nonspecific Cell Uptake
ACS Nano (IF 13.903) Pub Date : 2018-01-08 ,DOI:10.1021/acsnano.7b03025
This work highlights an under-investigated mechanism of cell uptake that may have played a role in many other studies and also suggests that a wide variety of molecules can be used alongside PEGylation to stably passivate nanoparticle surfaces for low cell uptake. ...
Ex Vivo Detection of Circulating Tumor Cells from Whole Blood by Direct Nanoparticle Visualization
ACS Nano (IF 13.903) Pub Date : 2018-02-07 ,DOI:10.1021/acsnano.7b08813
Here, a method for the direct visualization of nanoparticle-coated CTCs under dark field illumination is presented. A metastatic breast cancer cell line (4T1) was transduced with a non-native target protein (Thy1.1). ...
Targeted Therapy of Atherosclerosis by a Broad-Spectrum Reactive Oxygen Species Scavenging Nanoparticle with Intrinsic Anti-inflammatory Activity
ACS Nano (IF 13.903) Pub Date : 2018-08-21 ,DOI:10.1021/acsnano.8b02037
TPCD could be easily processed into a nanoparticle (TPCD NP). The obtained nanotherapy TPCD NP could be efficiently and rapidly internalized by macrophages and vascular smooth muscle cells (VSMCs). ...
Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure
ACS Nano (IF 13.903) Pub Date : 2018-06-26 ,DOI:10.1021/acsnano.8b00553
We fabricated a nanoparticle that carries the beneficial regenerative factors from mesenchymal stem cells and further coated it with the membranes of red blood cells to increase blood stability. ...
Erythrocyte Membrane Cloaked Metal–Organic Framework Nanoparticle as Biomimetic Nanoreactor for Starvation-Activated Colon Cancer Therapy
ACS Nano (IF 13.903) Pub Date : 2018-10-03 ,DOI:10.1021/acsnano.8b05200
Herein, a biomimetic nanoreactor has been fabricated for starvation-activated cancer therapy by encapsulating GOx and prodrug tirapazamine (TPZ) in an erythrocyte membrane cloaked metal–organic framework (MOF) nanoparticle (TGZ@eM). ...
Dramatic Increase in Polymer Glass Transition Temperature under Extreme Nanoconfinement in Weakly Interacting Nanoparticle Films
ACS Nano (IF 13.903) Pub Date : 2018-05-31 ,DOI:10.1021/acsnano.8b01341
Capillary rise infiltration enables polymer infiltration into nanoparticle (NP) packings, thereby confining polymers within extremely small pores and dramatically increasing the interfacial area, providing a good system to systematically distinguish the role of each effect on polymer properties. ...
Fluctuation Effects on the Brush Structure of Mixed Brush Nanoparticles in Solution
ACS Nano (IF 13.903) Pub Date : 2018-01-25 ,DOI:10.1021/acsnano.7b08271
A potentially attractive way to control nanoparticle assembly is to graft one or more polymers on the nanoparticle, to control the nanoparticle–nanoparticle interactions. ...
Synergistic Toxicity Produced by Mixtures of Biocompatible Gold Nanoparticles and Widely Used Surfactants
ACS Nano (IF 13.903) Pub Date : 2018-05-16 ,DOI:10.1021/acsnano.8b00036
These results demonstrate a need for additional, foundational studies to understand the effects of surfactants on nanoparticle biocompatibility and challenge traditional models of nanoparticle safety where the matrix is assumed to have only additive effects on nanoparticle toxicity. ...
Oral Nanoparticles Exhibit Specific High-Efficiency Intestinal Uptake and Lymphatic Transport.
ACS Nano (IF 13.903) Pub Date : 2018-08-09 ,DOI:10.1021/acsnano.8b04315
The probe nanoparticle exhibited a significantly enhanced average oral bioavailability (47%) with sustained absorption in rats. Particle-size- and dose-dependent oral bioavailability was observed for oral nanoparticle dosing up to 20 mg/kg. ...
Dense and Dynamic Polyethylene Glycol Shells Cloak Nanoparticles from Uptake by Liver Endothelial Cells for Long Blood Circulation
ACS Nano (IF 13.903) Pub Date : 2018-08-23 ,DOI:10.1021/acsnano.8b04947
By engineering a hierarchical polyethylene glycol (PEG) structure on nanoparticle surfaces, we revealed an alternative mechanism to enhance nanoparticle blood circulation. ...
Hierarchical Crystals Formed from DNA-Functionalized Janus Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2018-09-10 ,DOI:10.1021/acsnano.8b04753
Harnessing anisotropic interactions in a DNA-mediated nanoparticle assembly holds great promise as a rational strategy to advance this important area. ...
Big Potential from Small Agents: Nanoparticles for Imaging-Based Companion Diagnostics
ACS Nano (IF 13.903) Pub Date : 2018-03-01 ,DOI:10.1021/acsnano.7b07252
This review provides an overview of many ways nanoparticle imaging agents have contributed to cancer imaging, both preclinically and in the clinic, as well as charting future directions in companion diagnostics. ...
Bioengineered Norovirus S60 Nanoparticles as a Multifunctional Vaccine Platform
ACS Nano (IF 13.903) Pub Date : 2018-09-25 ,DOI:10.1021/acsnano.8b02776
Furthermore, the S60 nanoparticle can display other antigens, supporting the notion that the S60 nanoparticle is a multifunctional vaccine platform. ...
Conformational Details of Quantum Dot-DNA Resolved by Förster Resonance Energy Transfer Lifetime Nanoruler
ACS Nano (IF 13.903) Pub Date : 2018-12-06 ,DOI:10.1021/acsnano.8b07137
DNA-nanoparticle conjugates are important tools in nanobiotechnology. Knowing the orientation, function, and length of DNA on nanoparticle surfaces at low nanomolar concentrations under physiological conditions is therefore of great interest. ...
Dynamical Magnetic Response of Iron Oxide Nanoparticles Inside Live Cells
ACS Nano (IF 13.903) Pub Date : 2018-03-09 ,DOI:10.1021/acsnano.7b08995
However, a dramatic and unexplained reduction of the nanoparticle magnetic heating efficiency has been evidenced when nanoparticles are located inside cells or tissues. ...
Switching of Current Rectification Ratios within a Single Nanocrystal by Facet-Resolved Electrical Wiring
ACS Nano (IF 13.903) Pub Date : 2018-07-11 ,DOI:10.1021/acsnano.8b02934
This concept is scalable to large 2D arrays, up to millimeters in size, with implications in the design and understanding of nanoparticle circuitry. ...
Impact of Solution Chemistry and Particle Anisotropy on the Collective Dynamics of Oriented Aggregation
ACS Nano (IF 13.903) Pub Date : 2018-09-19 ,DOI:10.1021/acsnano.8b04909
Although oriented aggregation of particles is a widely recognized mechanism of crystal growth, the impact of many fundamental parameters, such as crystallographically distinct interfacial structures, solution composition, and nanoparticle morphology, on the governing mechanisms and assembly kinetics ...
Nanocolloidal Hydrogel for Heavy Metal Scavenging
ACS Nano (IF 13.903) Pub Date : 2018-07-13 ,DOI:10.1021/acsnano.8b03202
We report a nanocolloidal hydrogel that combines the advantages of molecular hydrogels and nanoparticle-based scavengers of heavy metal ions. The hydrogel was formed by the chemical cross-linking of cellulose nanocrystals and graphene quantum dots. ...
Direct Assembly of Large Area Nanoparticle Arrays
ACS Nano (IF 13.903) Pub Date : 2018-07-24 ,DOI:10.1021/acsnano.8b02932
A major goal of nanotechnology is the assembly of nanoscale building blocks into functional optical, electrical, or chemical devices. Many of these applications depend on an ability to optically or electrically address single nanoparticles. However, positioning large numbers of single nanocrystals with nanometer precision on a substrate for integration into solid-state devices remains a fundamental roadblock. Here, we report fast, scalable assembly of thousands of single nanoparticles using electrophoretic deposition. We demonstrate that gold nanospheres down to 30 nm in size and gold nanorods <100 nm in length can be assembled into predefined patterns on transparent conductive substrates within a few seconds. We find that rod orientation can be preserved during deposition. As proof of high fidelity scale-up, we have created centimeter scale patterns comprising more than 1 million gold nanorods. ...
Reconfigurable Microfluidic Droplets Stabilized by Nanoparticle Surfactants
ACS Nano (IF 13.903) Pub Date : 2018-03-12 ,DOI:10.1021/acsnano.7b07635
Interfacial assemblies of nanoparticles can stabilize liquid–liquid interfaces. Due to the interactions between functional groups on nanoparticles dispersed in one liquid and polymers having complementary end-functionality dissolved in a second immiscible fluid, the anchoring of a well-defined number of polymer chains onto the nanoparticles leads to the formation of NP–surfactants that assemble at the interface and reduce the interfacial energy. We have developed droplet interfaces covered with elastic, responsive monolayers of NP–surfactants. Due to the presence of an elastic layer at the interface, the droplets offer a greater resistance to coalescence and can prevent the exchange of materials across interfaces. Our results show the successful encapsulation of nanoparticles, dyes, and proteins with diameters in the 2.4–30 nm range. Further, we show that stable water-in-oil droplets can be generated for various combinations of polymer ligands and nanoparticles bearing complementary functionalities. These NP–surfactant-stabilized microfluidic emulsions would enable applications requiring liquid–liquid interfaces that can adapt and respond to external stimuli and whose mechanical properties can be easily tailored. ...
Understanding the Effects of Nanocapsular Mechanical Property on Passive and Active Tumor Targeting
ACS Nano (IF 13.903) Pub Date : 2018-03-02 ,DOI:10.1021/acsnano.8b00242
Further in vivo experiments confirmed these findings and demonstrated the critical role of nanoparticlemechanical properties in regulating their interactions with biological systems. ...
Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy
ACS Nano (IF 13.903) Pub Date : 2018-02-06 ,DOI:10.1021/acsnano.7b05876
The platforms we discuss are diverse in their approaches to the delivery problem and provide valuable insight into guiding the design of future nanoparticle-based TRAIL cancer therapeutics to potentially enable future translation into the clinic. ...
Controllable Multigeometry Nanoparticles via Cooperative Assembly of Amphiphilic Diblock Copolymer Blends with Asymmetric Architectures
ACS Nano (IF 13.903) Pub Date : 2018-02-05 ,DOI:10.1021/acsnano.7b07777
We show an efficient approach for controllable multigeometry nanoparticle construction that will be useful for multifunctional and hierarchical nanomaterials. ...
Atomic-Scale Structure and Stress Release Mechanism in Core–Shell Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2018-11-26 ,DOI:10.1021/acsnano.8b06118
Accordingly, strain in the Pd shell is several times larger in the extended facets than near the edges and corners of the nanoparticle, which likely affects adsorption, optical, and electrochemical properties. ...
Quantitative Assessment of Nanoparticle Biodistribution by Fluorescence Imaging, Revisited
ACS Nano (IF 13.903) Pub Date : 2018-07-02 ,DOI:10.1021/acsnano.8b02881
Fluorescence-based whole-body imaging is widely used in the evaluation of nanoparticles (NPs) in small animals, often combined with quantitative analysis to indicate their spatiotemporal distribution following systemic administration. An underlying assumption is that the fluorescence label represents NPs and the intensity increases with the amount of NPs and/or the labeling dyes accumulated in the region of interest. We prepare DiR-loaded poly(lactic-co-glycolic acid) (PLGA) NPs with different surface layers (polyethylene glycol with and without folate terminus) and compare the distribution of fluorescence signals in a mouse model of folate-receptor-expressing tumors by near-infrared fluorescence whole-body imaging. Unexpectedly, we observe that fluorescence distribution patterns differ far more dramatically with DiR loading than with the surface ligand, reaching opposite conclusions with the same type of NPs (tumor-specific delivery vs predominant liver accumulation). Analysis of DiR-loaded PLGA NPs reveals that fluorescence quenching, dequenching, and signal saturation, which occur with the increasing dye content and local NP concentration, are responsible for the conflicting interpretations. This study highlights the critical need for validating fluorescence labeling of NPs in the quantitative analysis of whole-body imaging. In light of our observation, we make suggestions for future whole-body fluorescence imaging in the in vivo evaluation of NP behaviors. ...
Damping Off Terahertz Sound Modes of a Liquid upon Immersion of Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2018-08-01 ,DOI:10.1021/acsnano.8b03101
The control of phonon propagation in nanoparticle arrays is one of the frontiers of nanotechnology, potentially enabling the discovery of materials with unknown functionalities for potential innovative applications. ...
Plasmonic Hot-Carrier-Mediated Tunable Photochemical Reactions
ACS Nano (IF 13.903) Pub Date : 2018-07-18 ,DOI:10.1021/acsnano.8b03830
Numerical simulations demonstrate that, after photoexcitation, hot carriers transfer to the antibonding state of the H2 molecule from the nanoparticle, resulting in a repulsive-potential-energy surface and H2 dissociation. This process occurs when the molecule is close to a single nanoparticle. ...
Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice
ACS Nano (IF 13.903) Pub Date : 2018-04-04 ,DOI:10.1021/acsnano.7b08172
Herein, we report a polymeric nanoparticle system modified with brain-targeting peptide rabies virus glycoprotein (RVG) 29 that can intracerebrally deliver DFO. The nanoparticle system penetrates the BBB possibly through specific receptor-mediated endocytosis triggered by the RVG29 peptide. ...
Nanoparticle-Mediated Remodeling of the Tumor Microenvironment to Enhance Immunotherapy
ACS Nano (IF 13.903) Pub Date : 2018-12-06 ,DOI:10.1021/acsnano.8b05893
Nanoscience has long been lauded as a method through which tumor-associated barriers could be overcome. As successful as cancer immunotherapy has been, limitations associated with the tumor microenvironment or side effects of systemic treatment have become more apparent. In this Review, we seek to lay out the therapeutic challenges associated with the tumor microenvironment and the ways in which nanoscience is being applied to remodel the tumor microenvironment and increase the susceptibility of many cancer types to immunotherapy. We detail the nanomedicines on the cutting edge of cancer immunotherapy and how their interactions with the tumor microenvironment make them more effective than systemically administered immunotherapies. ...
Cancer Treatment through Nanoparticle-Facilitated Fenton Reaction
ACS Nano (IF 13.903) Pub Date : 2018-11-28 ,DOI:10.1021/acsnano.8b07635
Currently, cancer is the second largest cause of death worldwide and has reached critical levels. In spite of all the efforts, common treatments including chemotherapy, photodynamic therapy, and photothermal therapy suffer from various problems which limit their efficiency and performance. For this reason, different strategies are being explored which improve the efficiency of these traditional therapeutic methods or treat the tumor cells directly. One such strategy utilizing the Fenton reaction has been investigated by many groups for the possible treatment of cancer cells. This approach is based on the knowledge that high levels of hydrogen peroxide exist within cancer cells and can be used to catalyze the Fenton reaction, leading to cancer-killing reactive oxygen species. Analysis of the current literature has shown that, due to the diverse morphologies, different sizes, various chemical properties, and the tunable structure of nanoparticles, nanotechnology offers the most promising method to facilitate the Fenton reaction with cancer therapy. This review aims to highlight the use of the Fenton reaction using different nanoparticles to improve traditional cancer therapies and the emerging Fenton-based therapy, highlighting the obstacles, challenges, and promising developments in each of these areas. ...
Epidermal Growth Factor Receptor-Targeting Peptide Nanoparticles Simultaneously Deliver Gemcitabine and Olaparib To Treat Pancreatic Cancer with Breast Cancer 2 (BRCA2) Mutation
ACS Nano (IF 13.903) Pub Date : 2018-11-12 ,DOI:10.1021/acsnano.8b01573
To address this issue, we have engineered an epidermal growth factor receptor (EGFR) targeting (with GE11 peptide) self-assembly amphiphilic peptide nanoparticle (GENP) to co-deliver gemcitabine and the PARPi olaparib to treat BRCA mutant PCa. ...
High-Pressure Effect on the Optical Extinction of a Single Gold Nanoparticle
ACS Nano (IF 13.903) Pub Date : 2018-10-09 ,DOI:10.1021/acsnano.8b05539
When reducing the size of a material from bulk down to nanoscale, the enhanced surface-to-volume ratio and the presence of interfaces make the properties of nano-objects very sensitive not only to confinement effects but also to their local environment. In the optical domain, the latter dependence can be exploited to tune the plasmonic response of metal nanoparticles by controlling their surroundings, notably applying high pressures. To date, only a few optical absorption experiments have demonstrated this feasibility, on ensembles of metal nanoparticles in a diamond anvil cell. Here, we report a nontrivial combination between a spatial modulation spectroscopy microscope and an ultraflat diamond anvil cell, allowing us to quantitatively investigate the high-pressure optical extinction spectrum of an individual nano-object. A large tuning of the surface plasmon resonance of a gold nanobipyramid is experimentally demonstrated up to 10 GPa, in quantitative agreement with finite-element simulations and an analytical model disentangling the impact of metal and local environment dielectric modifications. High-pressure optical characterizations of single nanoparticles allow for the accurate investigation and modeling of size, strain, and environment effects on physical properties of nano-objects and also enable fine-tuned applications in nanocomposites, nanoelectromechanical systems, or nanosensing devices. ...
A Gold/Silver Hybrid Nanoparticle for Treatment and Photoacoustic Imaging of Bacterial Infection
ACS Nano (IF 13.903) Pub Date : 2018-05-14 ,DOI:10.1021/acsnano.8b01362
Ag+ ions are a well-known antibacterial agent, and Ag nanoparticles act as a reservoir of these Ag+ ions for targeted therapy of bacterial infections. However, there are no tools to effectively trigger and monitor the release of Ag+ ions from Ag nanoparticles. Photoacoustic (PA) imaging is an emerging noninvasive imaging tool, and gold nanorods (AuNRs) are an excellent contrast agent for PA imaging. In this work, we developed Au/Ag hybrid nanoparticles by coating AuNRs with silver (Ag), which decreased their photoacoustic signal. The as-prepared, Ag-coated Au nanorods (Au/AgNRs) are stable under ambient conditions, but the addition of ferricyanide solution (1 mM) results in oxidative etching of the silver shell. The PA contrast is simultaneously recovered as the silver is released, and this PA signal offers noninvasive monitoring of localized release of Ag+ ions. The released Ag+ ions exhibit a strong bactericidal efficacy similar to equivalent free Ag+ ions (AgNO3), and the nanoparticles killed >99.99% of both (Gram-positive) methicillin-resistant Staphylococcus aureus (MRSA, 32 μM Ag+ equivalent) and (Gram-negative) Escherichia coli (8 μM Ag+ equivalent). The theranostic potential of these nanoparticles was demonstrated in a pilot in vivo study. Mice were inoculated with MRSA and Au/AgNRs were subcutaneously implanted followed by silver etching. There was a 730% increase in the PA signal (p < 0.01) pre- and post-etching, and the bacterial counts in infected tissues of the treated group were reduced by 1000-fold (log CFU/g = 4.15 vs 7.75) versus the untreated control; this treatment efficacy was confirmed with histology. We further showed that these hybrid nanoparticles could release Ag+ after stimulation by reactive oxygen species including hydrogen peroxide and peroxynitrite. These hybrid Au/Ag nanoparticles are a useful theranostic agent for the photoacoustic imaging and treatment of bacterial infections. ...
Nanoparticle-Enhanced Plasmonic Biosensor for Digital Biomarker Detection in a Microarray
ACS Nano (IF 13.903) Pub Date : 2018-05-08 ,DOI:10.1021/acsnano.8b00519
Nanoplasmonic devices have become a paradigm for biomolecular detection enabled by enhanced light–matter interactions in the fields from biological and pharmaceutical research to medical diagnostics and global health. In this work, we present a bright-field imaging plasmonic biosensor that allows visualization of single subwavelength gold nanoparticles (NPs) on large-area gold nanohole arrays (Au-NHAs). The sensor generates image heatmaps that reveal the locations of single NPs as high-contrast spikes, enabling the detection of individual NP-labeled molecules. We implemented the proposed method in a sandwich immunoassay for the detection of biotinylated bovine serum albumin (bBSA) and human C-reactive protein (CRP), a clinical biomarker of acute inflammatory diseases. Our method can detect 10 pg/mL of bBSA and 27 pg/mL CRP in 2 h, which is at least 4 orders of magnitude lower than the clinically relevant concentrations. Our sensitive and rapid detection approach paired with the robust large-area plasmonic sensor chips, which are fabricated using scalable and low-cost manufacturing, provides a powerful platform for multiplexed biomarker detection in various settings. ...
Substrate- to Laterally-Driven Self-Assembly Steered by Cu Nanoclusters: The Case of FePcs on an Ultrathin Alumina Film
ACS Nano (IF 13.903) Pub Date : 2018-09-17 ,DOI:10.1021/acsnano.8b05992
By exploiting the capability of an ultrathin alumina film to host metallic nanoparticle seeds, we tune the symmetry of a iron phthalocyanine (FePc) two-dimensional crystal, thus showing that it is possible to switch from trans to lateral dominating interactions in the controlled growth of an organic/ ...
Chemistry of Shape-Controlled Iron Oxide Nanocrystal Formation
ACS Nano (IF 13.903) Pub Date : 2018-12-17 ,DOI:10.1021/acsnano.8b05032
This protocol enabled us to analyze each step of nanoparticle formation independently in depth. ...
Universal Scaling and Design Rules of Hydrogen-Induced Optical Properties in Pd and Pd-Alloy Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2018-09-11 ,DOI:10.1021/acsnano.8b02835
In addition to this correlation, we establish that the amplitude of optical signal change is defined solely by the spectral plasmon resonance position in the non-hydrogenated state for a specific nanoparticlecomposition. ...
Engineering a Rugged Nanoscaffold To Enhance Plug-and-Display Vaccination
ACS Nano (IF 13.903) Pub Date : 2018-07-26 ,DOI:10.1021/acsnano.8b02805
SpyCatcher-mi3 expressed solubly to high yields in Escherichia coli, giving more than 10-fold greater yield than a comparable phage-derived icosahedral nanoparticle, SpyCatcher-AP205. ...
Prostate-Specific Membrane Antigen Targeted Gold Nanoparticles for Theranostics of Prostate Cancer
ACS Nano (IF 13.903) Pub Date : 2018-04-16 ,DOI:10.1021/acsnano.8b00940
In vitro cellular uptake experiments demonstrated significantly higher nanoparticle uptake in PSMA-positive PC3pip cells than in PSMA-negative PC3flu cells. ...
Robust Bijels for Reactive Separation via Silica-Reinforced Nanoparticle Layers
ACS Nano (IF 13.903) Pub Date : 2018-12-11 ,DOI:10.1021/acsnano.8b05718
Pickering emulsions have been successfully used as media for catalysis and separation. However, simultaneous reaction and separation cannot be performed in a continuous mode in these systems, because reagents cannot be readily loaded into or recovered from the dispersed phase. Bicontinuous interfacially jammed emulsion gels (bijels), in which the oil and water phases are continuous throughout the structure, have potential as media for simultaneous reaction and separation in a continuous mode. In this work, we take a major step toward realizing this vision by demonstrating the ability of bijels to be used in reactive separation performed in a batch fashion. To perform effectively, bijels must maintain their morphology and interfacial mass transfer properties during reaction. To strengthen the bijels, we modify the solvent transfer-induced phase separation (STRIPS) method to make bijels resistant to mechanical stresses and prevent detachment of nanoparticles from the oil/water interface due to pH changes by chemically fusing the interfacial nanoparticles. The reinforced bijel is successfully tested in base-catalyzed hydrolysis of esters and remains robust under these challenging conditions. ...
Physicochemical Properties Can Be Key Determinants of Mesoporous Silica Nanoparticle Potency in Vitro
ACS Nano (IF 13.903) Pub Date : 2018-12-04 ,DOI:10.1021/acsnano.8b04910
Nanoforms of mesoporous silica (mSiNPs) are increasingly applied in medicine, imaging, energy storage, catalysis, biosensors, and bioremediation. The impact of their physicochemical properties on health and the environment remain to be elucidated. In this work, newly synthesized mesoporous silica (sizes: 25, 70, 100, 170, and 600 nm; surface functionalization: pristine, C3-, and C11-COOH moieties) were assessed for cytotoxicity and induction of inflammatory responses in vitro (A549, THP-1, J774A.1 cells). All toxicity end points were integrated to obtain simple descriptors of biological potencies of these mSiNPs. The findings indicate that mSiNPs are less bioactive than the nonporous reference SiNP used in this study. The C3-COOH-modified mSiNPs were generally less cytotoxic than their pristine and C11-modified counterparts in the nanorange (≤100 nm). Carboxyl-modified mSiNPs affected inflammatory marker release across all sizes with cell-type specificity, suggesting a potential for immunomodulatory effects. Surface area, size, extent of agglomeration, ζ-potential, and surface modification appeared to be important determinants of cytotoxicity of mSiNPs based on association tests. Pathway analysis identified particle and cell-type-specific alteration of cellular pathways and functions by mSiNPs. The integration of exposure-related biological responses of multiple cell lines to mSiNPs allowed for a comprehensive evaluation of the impact of physicochemical factors on their toxicity characteristics. The integrated multilevel toxicity assessment approach can be valuable as a hazard screening tool for safety evaluations of emerging nanomaterials for regulatory purpose. ...
Gold Nanoparticle Plasmonic Superlattices as Surface-Enhanced Raman Spectroscopy Substrates
ACS Nano (IF 13.903) Pub Date : 2018-08-17 ,DOI:10.1021/acsnano.8b04073
Metal colloids are of great interest in the field of nanophotonics, mainly due to their morphology-dependent optical properties, but also because they are high-quality building blocks for complex plasmonic architectures. Close-packed colloidal supercrystals not only serve for investigating the rich plasmonic resonances arising in strongly coupled arrangements but also enable tailoring the optical response, on both the nano- and the macroscale. Bridging these vastly different length scales at reasonable fabrication costs has remained fundamentally challenging, but is essential for applications in sensing, photovoltaics or optoelectronics, among other fields. We present here a scalable approach to engineer plasmonic supercrystal arrays, based on the template-assisted assembly of gold nanospheres with topographically patterned polydimethylsiloxane molds. Regular square arrays of hexagonally packed supercrystals were achieved, reaching periodicities down to 400 nm and feature sizes around 200 nm, over areas up to 0.5 cm2. These two-dimensional supercrystals exhibit well-defined collective plasmon modes that can be tuned from the visible through the near-infrared by simple variation of the lattice parameter. We present electromagnetic modeling of the physical origin of the underlying hybrid modes and demonstrate the application of superlattice arrays as surface-enhanced Raman scattering (SERS) spectroscopy substrates which can be tailored for a specific probe laser. We therefore investigated the influence of the lattice parameter, local degree of order, and cluster architecture to identify the optimal configuration for highly efficient SERS of a nonresonant Raman probe with 785 nm excitation. ...
Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin
ACS Nano (IF 13.903) Pub Date : 2018-12-11 ,DOI:10.1021/acsnano.8b04338
Here, we address this need by developing a pharmacokinetically optimized, 64Cu-labeled polyglucose nanoparticle (Macrin) for quantitative positron emission tomography (PET) imaging of macrophages in tumors. ...
Migration of Iron Oxide Nanoparticle through a Silica Shell by the Redox-Buffering Effect
ACS Nano (IF 13.903) Pub Date : 2018-09-26 ,DOI:10.1021/acsnano.8b04520
This study demonstrates that mineral redox buffer, an important concept in geology, can be used to manipulate the migration of nanoparticles and produce nanostructures of unexpected morphologies. Using a silica shell as a redox buffer, we show that iron oxide nanoparticles can be relocated from inside to the outer surface of the silica shell. The migration of iron oxide through silica was initiated by manipulation of the oxygen fugacity conditions at an elevated temperature. During the treatment, iron oxide was absorbed and then separated from the silica shell by the formation and then decomposition of iron silicate (Fe2SiO4). Tuning the relative dimensions of the iron oxide core and silica shell allows control of the shape of the iron oxide–silica composite structures. It is believed that the discovery of the nanoscale redox buffering effect can be extended to control the morphological configuration of other multivalent metal oxide nanocomposite structures by this particular type of template synthesis through manipulation of the chemical-transport properties of nanoscale templates. ...
Breaking the Nanoparticle Loading–Dispersion Dichotomy in Polymer Nanocomposites with the Art of Croissant-Making
ACS Nano (IF 13.903) Pub Date : 2018-09-17 ,DOI:10.1021/acsnano.8b02877
The intrinsic properties of nanomaterials offer promise for technological revolutions in many fields, including transportation, soft robotics, and energy. Unfortunately, the exploitation of such properties in polymer nanocomposites is extremely challenging due to the lack of viable dispersion routes when the filler content is high. We usually face a dichotomy between the degree of nanofiller loading and the degree of dispersion (and, thus, performance) because dispersion quality decreases with loading. Here, we demonstrate a potentially scalable pressing-and-folding method (P & F), inspired by the art of croissant-making, to efficiently disperse ultrahigh loadings of nanofillers in polymer matrices. A desired nanofiller dispersion can be achieved simply by selecting a sufficient number of P & F cycles. Because of the fine microstructural control enabled by P & F, mechanical reinforcements close to the theoretical maximum and independent of nanofiller loading (up to 74 vol %) were obtained. We propose a universal model for the P & F dispersion process that is parametrized on an experimentally quantifiable “D factor”. The model represents a general guideline for the optimization of nanocomposites with enhanced functionalities including sensing, heat management, and energy storage. ...
Graphene Oxide–Upconversion Nanoparticle Based Portable Sensors for Assessing Nutritional Deficiencies in Crops
ACS Nano (IF 13.903) Pub Date : 2018-06-06 ,DOI:10.1021/acsnano.8b03261
The development of innovative technologies to rapidly detect biomarkers associated with nutritional deficiencies in crops is highly relevant to agriculture and thus could impact the future of food security. Zinc (Zn) is an important micronutrient in plants, and deficiency leads to poor health, quality, and yield of crops. We have developed portable sensors, based on graphene oxide and upconversion nanoparticles, which could be used in the early detection of Zn deficiency in crops, sensing mRNAs encoding members of the ZIP-transporter family in crops. ZIPs are membrane transport proteins, some of which are up-regulated at the early stages of Zn deficiency, and they are part of the biological mechanism by which crops respond to nutritional deficiency. The principle of these sensors is based on the intensity of the optical output resulting from the interaction of oligonucleotide-coated upconversion nanoparticles and graphene oxide in the absence or presence of a specific oligonucleotide target. The sensors can reliably detect mRNAs in RNA extracts from plants using a smartphone camera. Our work introduces the development of accurate and highly sensitive sensors for use in the field to determine crop nutrient status and ultimately facilitate economically important nutrient management decisions. ...
Defects and Chirality in the Nanoparticle-Directed Assembly of Spherocylindrical Shells of Virus Coat Proteins
ACS Nano (IF 13.903) Pub Date : 2018-04-25 ,DOI:10.1021/acsnano.8b00069
Virus coat proteins of small isometric plant viruses readily assemble into symmetric, icosahedral cages encapsulating noncognate cargo, provided the cargo meets a minimal set of chemical and physical requirements. While this capability has been intensely explored for certain virus-enabled nanotechnologies, additional applications require lower symmetry than that of an icosahedron. Here, we show that the coat proteins of an icosahedral virus can efficiently assemble around metal nanorods into spherocylindrical closed shells with hexagonally close-packed bodies and icosahedral caps. Comparison of chiral angles and packing defects observed by in situ atomic force microscopy with those obtained from molecular dynamics models offers insight into the mechanism of growth, and the influence of stresses associated with intrinsic curvature and assembly pathways. ...
Ligand Density and Nanoparticle Clustering Cooperate in the Multivalent Amplification of Epidermal Growth Factor Receptor Activation
ACS Nano (IF 13.903) Pub Date : 2018-10-11 ,DOI:10.1021/acsnano.8b06141
Multivalent presentation of ligands on nanoparticles (NPs) is considered a general strategy for enhancing receptor binding and activation through amplification of ligand–receptor interactions within the footprint of the individual NPs. The spatial clustering of ligand-functionalized NPs represents an additional, less well understood mechanism for increasing local ligand–receptor interactions, especially for receptors that form higher-order assemblies, such as the epidermal growth factor (EGF) receptor (EGFR). To shed light on the interplay between ligand density (i.e., multivalency) and NP clustering in signal amplification, we apply EGF-functionalized 72 ± 1 nm gold nanoparticles (NP-EGF) with known ligand loading (10–200 EGF/NP) as quantifiable and experimentally tractable units of EGFR activation and characterize the NP-mediated amplification of EGFR phosphorylation as a function of both EGF surface density and NP-EGF clustering for two cancer cell lines (HeLa and MDA-MB-468). The measurements confirm a strong multivalent amplification of EGFR phosphorylation through NP-EGF on the cellular level that results in EGF-loading-dependent maximum EGFR phosphorylation levels. A microscopic analysis of NP-EGF-induced EGFR phosphorylation reveals a heterogeneous spatial distribution of EGFR activation across the cell surface. Clustering of multivalent NP-EGF on sub-diffraction-limited length scales is found to result in a local enhancement of EGFR phosphorylation in signaling “hot spots” from where the signal can spread laterally in an EGF-independent fashion. Increasing EGF loadings of the NP enhances NP-EGF clustering and intensifies EGFR phosphorylation. These observations suggest that NP-EGF clustering and the associated local enhancement of ligand–receptor interactions are intrinsic components of the multivalent amplification of phosphorylation for the heterogeneously distributed EGFR through NP-EGF. ...
Charge Transport Modulation in PbSe Nanocrystal Solids by AuxAg1–x Nanoparticle Doping
ACS Nano (IF 13.903) Pub Date : 2018-08-30 ,DOI:10.1021/acsnano.8b03112
Nanocrystal (NC) solids are an exciting class of materials, whose physical properties are tunable by choice of the NCs as well as the strength of the interparticle coupling. One can consider these NCs as “artificial atoms” in analogy to the formation of condensed matter from atoms. Akin to atomic doping, the doping of a semiconducting NC solid with impurity NCs can drastically alter its electronic properties. A high degree of complexity is possible in these artificial structures by adjusting the size, shape, and composition of the building blocks, which enables “designer” materials with targeted properties. Here, we present the doping of the PbSe NC solids with a series of AuxAg1–x alloy nanoparticles (NPs). A combination of temperature-dependent electrical conductance and Seebeck coefficient measurements and room-temperature Hall effect measurements demonstrates that the incorporation of metal NPs both modifies the charge carrier density of the NC solids and introduces energy barriers for charge transport. These studies point to charge carrier injection from the metal NPs into the PbSe NC matrix. The charge carrier density and charge transport dynamics in the doped NC solids are adjustable in a wide range by employing the AuxAg1–x NP with different Au:Ag ratio as dopants. This doping strategy could be of great interest for thermoelectric applications taking advantage of the energy filtering effect introduced by the metal NPs. ...
Ultrafast Light-Controlled Growth of Silver Nanoparticles for Direct Plasmonic Color Printing
ACS Nano (IF 13.903) Pub Date : 2018-08-31 ,DOI:10.1021/acsnano.8b02868
The silver nanoparticle–TiO2–quartz structure exhibits a Fano-like reflection spectrum, whose spectral dip can be tuned by the dimension of the silver nanoparticles for plasmonic color generation. ...
Bimetallic Nanoparticle Oxidation in Three Dimensions by Chemically Sensitive Electron Tomography and in Situ Transmission Electron Microscopy
ACS Nano (IF 13.903) Pub Date : 2018-08-13 ,DOI:10.1021/acsnano.8b02170
The formation of hollow-structured oxide nanoparticles is primarily governed by the Kirkendall effect. However, the degree of complexity of the oxidation process multiplies in the bimetallic system because of the incorporation of more than one element. Spatially dependent oxidation kinetics controls the final morphology of the hollow nanoparticles, and the process is highly dependent on the elemental composition. Currently, a theoretical framework that can predict how different metal elements result in different oxide morphologies remains elusive. In this work, utilizing a combination of state-of-the-art in situ environmental transmission electron microscopy and three-dimensional (3D) chemically sensitive electron tomography, we provide an in situ and 3D investigation of the oxidation mechanism of the Ni–Fe nanoparticles. The direct measurements allow us to correlate the 3D elemental segregation in the particles with the oxidation morphologies, that is, single-cavity or dual-cavity hollow structure, and multicavity porous structures. Our findings in conjunction with theoretical calculations show that metal concentration, diffusivity, and particle size are important parameters that dictate the mechanical and phase stabilities of the hollow oxide shell, which in turn determine its barrier properties and the final hollow oxide morphology. It sheds light on how to use multielemental oxidation to control morphology in nanomaterials and demonstrates the power of 3D chemical imaging. ...
A Dual-Band Multilayer InSe Self-Powered Photodetector with High Performance Induced by Surface Plasmon Resonance and Asymmetric Schottky Junction
ACS Nano (IF 13.903) Pub Date : 2018-08-15 ,DOI:10.1021/acsnano.8b04931
A dual-band self-powered photodetector (SPPD) with high sensitivity is realized by a facile combination of InSe Schottky diode and Au plasmonic nanoparticle (NP) arrays. ...
“Minimalist” Nanovaccine Constituted from Near Whole Antigen for Cancer Immunotherapy
ACS Nano (IF 13.903) Pub Date : 2018-07-09 ,DOI:10.1021/acsnano.8b00558
The 50 nm-sized nanovaccine was developed comprising approximately 500 antigen molecules per nanoparticle. The nanovaccine prophylactically protected 70% of mice from tumorigenesis (0% for the control group) in murine B16-OVA melanoma. ...
Tailoring Platinum(IV) Amphiphiles for Self-Targeting All-in-One Assemblies as Precise Multimodal Theranostic Nanomedicine
ACS Nano (IF 13.903) Pub Date : 2018-06-21 ,DOI:10.1021/acsnano.8b03476
Drug, targeting ligand, and imaging agent are the three essential components in a nanoparticle-based drug delivery system. However, tremendous batch-to-batch variation of composition and drug content typically accompany the current approaches of building these components together. ...
Synthetic Cargo Internalization Receptor System for Nanoparticle Tracking of Individual Cell Populations by Fluorine Magnetic Resonance Imaging
ACS Nano (IF 13.903) Pub Date : 2018-11-05 ,DOI:10.1021/acsnano.8b05698
Specific detection of target structures or cells lacking particular surface epitopes still poses a serious problem for all imaging modalities. Here, we demonstrate the capability of synthetic “cargo internalization receptors” (CIRs) for tracking of individual cell populations by 1H/19F magnetic resonance imaging (MRI). To this end, a nanobody for green fluorescent protein (GFP) was used to engineer cell-surface-expressed CIRs which undergo rapid internalization after GFP binding. For 19F MR visibility, the GFP carrier was equipped with “contrast cargo”, in that GFP was coupled to perfluorocarbon nanoemulsions (PFCs). To explore the suitability of different uptake mechanisms for this approach, CIRs were constructed by combination of the GFP nanobody and three different cytoplasmic tails that contained individual internalization motifs for endocytosis of the contrast cargo (CIR1–3). Exposure of CIR+ cells to GFP-PFCs resulted in highly specific binding and internalization as confirmed by fluorescence microscopy as well as flow cytometry and enabled visualization by 1H/19F MRI. In particular, expression of CIR2/3 resulted in substantial incorporation of 19F cargo and readily enabled in vivo visualization of GFP-PFC recruitment to transplanted CIR+ cells by 1H/19F MRI in mice. Competition experiments with blood immune cells revealed that CIR+ cells are predominantly loaded with GFP-PFCs even in the presence of cells with strong phagocytotic capacity. Importantly, binding and internalization of GFP-PFCs did not result in the activation of signaling cascades and therefore does not alter cell physiology. Overall, this approach represents a versatile in vivo imaging platform for tracking of individual cell populations by making use of cell-type-specific CIR+ mice. ...
Differential Recognition of Nanoparticle Protein Corona and Modified Low-Density Lipoprotein by Macrophage Receptor with Collagenous Structure
ACS Nano (IF 13.903) Pub Date : 2018-04-26 ,DOI:10.1021/acsnano.8b02014
Key practical challenges such as understanding the immunological processes at the nanoscale and controlling the targeting and accumulation of nano-objects in vivo now further stimulate efforts to underpin phenomenological knowledge of the nanoscale with more mechanistic and molecular insight. Thus, the question as to what constitutes nanoscale biological identity continues to evolve. Certainly nanoparticles in contact with a complex biological milieu develop a biological identity, differing from the original nanomaterial, now referred to as the “biomolecular corona”. However, this surface-adsorbed layer of biomolecules may in some circumstance lead to different forms of receptor–particle interactions not evident only from the identity of the surface-adsorbed biomolecules and hard to predict or detect by current physicochemical methods. Here we show that scavenger receptors may recognize complex as yet unidentified biomolecular surface layer motifs, even when no current physicochemical analysis is capable of doing so. For instance, fluorescently labeled SiO2 nanoparticles in a biological milieu are strongly recognized by the macrophage receptor with collagenous structure (MARCO) in even dense biological media (human serum) apparently using a form of binding with which most of the MARCO’s known ligands (e.g., LPS, modified LDL) fail to compete. Such observations may suggest the need for a much stronger emphasis on nanoscale receptor–corona and other biomolecular interaction studies if one wishes to unravel how biomolecular recognition drives outcomes in the nanoscale biological domain. ...
Prismatic Deflection of Live Tumor Cells and Cell Clusters
ACS Nano (IF 13.903) Pub Date : 2018-11-21 ,DOI:10.1021/acsnano.8b07616
Here, we introduce the Prism Chip, a high-resolution immunomagnetic profiling and separation chip which harnesses a cobalt-based alloy to separate a flowing stream of nanoparticle-bound tumor cells with differential magnetic loading into 10 discrete streams. ...
Shape Transformation of Constituent Building Blocks within Self-Assembled Nanosheets and Nano-origami
ACS Nano (IF 13.903) Pub Date : 2018-01-05 ,DOI:10.1021/acsnano.7b08334
Such in situ transformation of nanoparticle building blocks can even be achieved in a free-standing two-dimensional system and three-dimensional origami. ...
Computational and Experimental Investigation of Janus-like Monolayers on Ultrasmall Noble Metal Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2018-10-26 ,DOI:10.1021/acsnano.8b05188
Experiments and simulations show quantitative agreement, and both indicate that the DDT/ME ligands undergo phase separation, resulting in Janus-like nanoparticle monolayers with large, patchy domains. ...
On-Axis Alignment of Protein Nanocage Assemblies from 2D to 3D through the Aromatic Stacking Interactions of Amino Acid Residues
ACS Nano (IF 13.903) Pub Date : 2018-10-02 ,DOI:10.1021/acsnano.8b06091
Moreover, these superlattices can serve as biotemplates for the fabrication of 2D and 3D inorganic nanoparticle arrays. ...
Surface-Enhanced Raman Scattering Nanoparticles for Multiplexed Imaging of Bladder Cancer Tissue Permeability and Molecular Phenotype
ACS Nano (IF 13.903) Pub Date : 2018-09-11 ,DOI:10.1021/acsnano.8b03217
To improve detection and resection of nonmuscle invasive bladder cancer, we quantified the ability of a surface-enhanced Raman nanoparticle and endoscope system to classify bladder tissue as normal or cancerous. ...
Nanoscale Mapping Functional Sites on Nanoparticles by Points Accumulation for Imaging in Nanoscale Topography (PAINT)
ACS Nano (IF 13.903) Pub Date : 2018-07-31 ,DOI:10.1021/acsnano.7b09063
Therefore, understanding the number and the distribution of nanoparticle functional groups is of utmost importance for the rational design of effective materials. ...
Crystalline Cyclophane–Protein Cage Frameworks
ACS Nano (IF 13.903) Pub Date : 2018-07-20 ,DOI:10.1021/acsnano.8b02856
Our cyclophane–protein cage frameworks bridge the gap between molecular frameworks and colloidal nanoparticle crystals and combine the versatility of synthetic supramolecular hosts with the highly selective recognition properties of biomolecules. ...
Controlling Disorder by Electric-Field-Directed Reconfiguration of Nanowires To Tune Random Lasing
ACS Nano (IF 13.903) Pub Date : 2018-07-05 ,DOI:10.1021/acsnano.8b03829
Here, we present a reconfigurable nanoparticle platform that can integrate heterogeneous particle assembly of different shapes, sizes, and chemical compositions. ...
Antibody–Antigen Interaction Dynamics Revealed by Analysis of Single-Molecule Equilibrium Fluctuations on Individual Plasmonic Nanoparticle Biosensors
ACS Nano (IF 13.903) Pub Date : 2018-09-05 ,DOI:10.1021/acsnano.8b04016
Antibody–antigen interactions are complex events central to immune response, in vivo and in vitro diagnostics, and development of therapeutic substances. We developed an ultrastable single-molecule localized surface plasmon resonance (LSPR) sensing platform optimized for studying antibody–antigen interaction kinetics over very long time scales. The setup allowed us to perform equilibrium fluctuations analysis of the PEG/anti-PEG interaction. By time and frequency domain analysis, we demonstrate that reversible adsorption of monovalently bound anti-PEG antibodies is the dominant factor affecting the LSPR fluctuations. The results suggest that equilibrium fluctuation analysis can be an alternative to established methods for determination of interaction rates. In particular, the methodology is suited to analyze molecular systems whose properties change during the initial interaction phases, for example, due to mass transport limitations or, as demonstrated here, because the effective association rate constant varies with surface concentration of adsorbed molecules. ...
Standing Enokitake-like Nanowire Films for Highly Stretchable Elastronics
ACS Nano (IF 13.903) Pub Date : 2018-09-18 ,DOI:10.1021/acsnano.8b05019
The closely packed nanoparticle layer sticks to the top of the nanowires, which easily cracks under strain, whereas the bottom part of the nanowires is compliant with substrate deformation. ...
Shell-Induced Ostwald Ripening: Simultaneous Structure, Composition, and Morphology Transformations during the Creation of Hollow Iron Oxide Nanocapsules
ACS Nano (IF 13.903) Pub Date : 2018-08-30 ,DOI:10.1021/acsnano.8b02946
A particularly elegant example of this latter approach involves the topotactic conversion of a nanoparticlefrom one structure and composition to another, since the orientation relationship between the initial and final product allows the crystallinity and orientation to be maintained throughout the ...
Cell Membrane Coated Semiconducting Polymer Nanoparticles for Enhanced Multimodal Cancer Phototheranostics
ACS Nano (IF 13.903) Pub Date : 2018-08-06 ,DOI:10.1021/acsnano.8b04066
Such biomimetic nanocamouflages comprise a near-infrared (NIR) absorbing semiconducting polymer nanoparticle (SPN) coated with the cell membranes of activated fibroblasts. ...
Sprayable Adhesive Nanotherapeutics: Mussel-Protein-Based Nanoparticles for Highly Efficient Locoregional Cancer Therapy
ACS Nano (IF 13.903) Pub Date : 2018-08-01 ,DOI:10.1021/acsnano.8b04533
Here, we propose a sprayable adhesive nanoparticle (NP)-based drug delivery system using a bioengineered mussel adhesive protein (MAP) for effective locoregional cancer therapy. ...
Nanosensors for the Chemical Imaging of Acetylcholine Using Magnetic Resonance Imaging
ACS Nano (IF 13.903) Pub Date : 2018-06-06 ,DOI:10.1021/acsnano.8b01640
Here, we introduce a class of nanoparticle sensors for the highly specific detection of acetylcholine in the living brain using magnetic resonance imaging. ...
Polymer–Nanoparticle Interaction as a Design Principle in the Development of a Durable Ultrathin Universal Binary Antibiofilm Coating with Long-Term Activity
ACS Nano (IF 13.903) Pub Date : 2018-10-29 ,DOI:10.1021/acsnano.8b05512
Bacterial attachment and biofilm formation pose major challenges to the optimal performance of indwelling devices. Current coating methods have significant deficiencies including the lack of long-term activity, easy of application, and adaptability to diverse materials. Here we describe a coating method that could potentially overcome such limitations and yield an ultrathin coating with long-term antibiofilm activity. We utilized the interaction between polydopamine (PDA) nanoaggregates/nanoparticles and ultrahigh molecular weight (uHMW) hydrophilic polymers to generate stable coatings with broad spectrum antibiofilm activity. We used a short-term bacterial adhesion assay as an initial screening method to identify coating compositions that give superior performance and found that only selected polymers (out of 13 different types) and molecular weights gave promising antifouling activity. Optimization of PDA self-assembly, polymer–PDA interaction, and deposition on the surface using uHMW poly(N,N-dimethylacrylamide) (PDMA) (∼795 kDa) resulted in a stable ultrathin coating (∼19 nm) with excellent antifouling and antibiofilm properties (>4 weeks) against diverse bacteria (∼108 CFU/mL) in shaking and flow conditions. The ultrathin coating is effective on diverse substrates including metals and polymeric substrates. The uHMW PDMA is stabilized in the coating via supramolecular interactions with PDA and generated a surface that is highly enriched with PDMA in aqueous conditions. Based on the surface analyses data, we also propose a mechanism for the stable coating formation. The molecular weight of PDMA is a crucial factor, and only uHMW polymers generate this property. An attractive feature of the coating is that it does not contain any antimicrobial agents and has the potential to prevent biofilm formation for diverse applications both short- and long-term. ...
Electrolyte Solvation Structure at Solid–Liquid Interface Probed by Nanogap Surface-Enhanced Raman Spectroscopy
ACS Nano (IF 13.903) Pub Date : 2018-09-25 ,DOI:10.1021/acsnano.8b05038
Herein, we report the study of Li+ salt solvation structure in aprotic solution in the immediate vicinity (∼20 nm) of the solid electrode–liquid interface using surface-enhanced Raman spectroscopy (SERS) from a gold nanoparticle (Au NP) monolayer. ...
Gold Nanorod Photothermal Therapy Alters Cell Junctions and Actin Network in Inhibiting Cancer Cell Collective Migration
ACS Nano (IF 13.903) Pub Date : 2018-08-27 ,DOI:10.1021/acsnano.8b04128
Whereas most researchers focus on single-cell migration, the effect of nanoparticle treatment on collective cell migration has not been explored. ...
Unconventional Janus Properties of Enokitake-like Gold Nanowire Films
ACS Nano (IF 13.903) Pub Date : 2018-07-26 ,DOI:10.1021/acsnano.8b04748
These Janus-like properties originate from enokitake-like nanowire structures, causing the nanoparticleside (“head”) to behave like bulk gold, yet the opposing nanowire side (“tail”) behaves as discontinuous nanophases. ...
In Situ Observation of Atomic Redistribution in Alloying Gold–Silver Nanorods
ACS Nano (IF 13.903) Pub Date : 2018-07-20 ,DOI:10.1021/acsnano.8b03978
Furthermore, the availability of a well-defined nanoparticle system has been an obstacle for a systematic investigation of the key factors governing the atomic redistribution. ...
Metasurfaces Leveraging Solar Energy for Icephobicity
ACS Nano (IF 13.903) Pub Date : 2018-06-29 ,DOI:10.1021/acsnano.8b02719
The balancing of transparency and absorption is achieved with rationally nanoengineered coatings consisting of gold nanoparticle inclusions in a dielectric (titanium dioxide), concentrating broadband absorbed solar energy into a small volume. ...
Synergistically Enhancing the Therapeutic Effect of Radiation Therapy with Radiation Activatable and Reactive Oxygen Species-Releasing Nanostructures
ACS Nano (IF 13.903) Pub Date : 2018-05-03 ,DOI:10.1021/acsnano.8b02038
Nanoparticle-based radio-sensitizers can amplify the effects of radiation therapy on tumor tissue even at relatively low concentrations while reducing the potential side effects to healthy surrounding tissues. ...
Rupture of Lipid Membranes Induced by Amphiphilic Janus Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2018-04-09 ,DOI:10.1021/acsnano.8b00759
This study provides direct evidence that the spatial arrangement of surface functionalities on a nanoparticle, rather than just its overall surface chemistry, plays a crucial role in determining how it interacts with biological membranes. ...
Mechanistic Insights into Photocatalyzed Hydrogen Desorption from Palladium Surfaces Assisted by Localized Surface Plasmon Resonances
ACS Nano (IF 13.903) Pub Date : 2018-03-23 ,DOI:10.1021/acsnano.8b00352
For example, heterogeneous photocatalysis can be achieved within heterometallic antenna-reactor complexes (HMARCs), by coupling a reactive center at which a chemical reaction occurs to a plasmonic nanoparticle that acts as a light-absorbing antenna. ...
Inkjet-Printed Biofunctional Thermo-Plasmonic Interfaces for Patterned Neuromodulation
ACS Nano (IF 13.903) Pub Date : 2018-02-08 ,DOI:10.1021/acsnano.7b06617
found that inkjet printing of plasmonic nanoparticles on a polyelectrolyte layer-by-layer substrate coating enables high-quality, biocompatible thermo-plasmonic interfaces across various substrates (rigid/flexible, hydrophobic/hydrophilic) by induced contact line pinning and electrostatically assisted nanoparticle ...
Nanoscale Control of Molecular Self-Assembly Induced by Plasmonic Hot-Electron Dynamics
ACS Nano (IF 13.903) Pub Date : 2018-01-23 ,DOI:10.1021/acsnano.7b08563
Here we use the highly localized light-to-chemical-energy conversion of plasmonic materials to spatially cleave Au–S bonds on predetermined locations within a single nanoparticle, enabling a high degree of control over this archetypal system for molecular self-assembly. ...
Nanocombinatorics with Cantilever-Free Scanning Probe Arrays
ACS Nano (IF 13.903) Pub Date : 2018-12-18 ,DOI:10.1021/acsnano.8b08185
For example, studying nanoparticle-based heterogeneous catalysis or the interaction between biological cells and abiotic surfaces requires precise tuning of materials composition on the nanometer scale. ...
Near-Infrared-Triggered in Situ Gelation System for Repeatedly Enhanced Photothermal Brachytherapy with a Single Dose
ACS Nano (IF 13.903) Pub Date : 2018-08-31 ,DOI:10.1021/acsnano.8b04544
This work presents an efficient type of NIR-responsive nanoparticle-encapsulated hydrogel system, inspiring the design of a form of brachytherapy. ...
Silane-Capped ZnO Nanoparticles for Use as the Electron Transport Layer in Inverted Organic Solar Cells
ACS Nano (IF 13.903) Pub Date : 2018-06-14 ,DOI:10.1021/acsnano.8b01178
With the aim of improving the stability of metal oxide nanoparticle dispersions and suppressing the formation of surface defects, we prepared 3-aminopropyltrimethoxysilane (APTMS)-capped ZnO (ZnO@APTMS) nanoparticles through surface ligand exchange. ...
Erythrocyte–Cancer Hybrid Membrane Camouflaged Hollow Copper Sulfide Nanoparticles for Prolonged Circulation Life and Homotypic-Targeting Photothermal/Chemotherapy of Melanoma
ACS Nano (IF 13.903) Pub Date : 2018-05-30 ,DOI:10.1021/acsnano.7b08355
The reported strategy may contribute to personalized nanomedicine of various tumors by combining the RBCs with a homotypic cancer membrane accordingly on the surface of the nanoparticle. ...
The Roles of Morphology on the Relaxation Rates of Magnetic Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2018-04-24 ,DOI:10.1021/acsnano.8b01048
These principles could serve as guidelines for design and development of high-performance nanoparticle-based contrast agents. ...
Metal Ion/Tannic Acid Assembly as a Versatile Photothermal Platform in Engineering Multimodal Nanotheranostics for Advanced Applications
ACS Nano (IF 13.903) Pub Date : 2018-03-28 ,DOI:10.1021/acsnano.8b01456
As a proof of concept, polymeric/inorganic nanoparticle/nanovesicle-supported FeIII-tannic acid (FeIIITA) is fabricated. The photothermal effect is shown to be unaffected by the template origin and type and FeIIITA thickness on the templates. ...
Influence of Salt on Supramolecular Oscillatory Structural Forces and Stratification in Micellar Freestanding Films
ACS Nano (IF 13.903) Pub Date : 2018-01-17 ,DOI:10.1021/acsnano.7b05391
In contrast to nanoparticle dispersions that show no influence of salt on step size, we find that the addition of salt to micellar freestanding films results in a decrease in step size as well as the number of stepwise transitions, in addition to changes in nucleation and growth of mesas, all driven ...
Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety
ACS Nano (IF 13.903) Pub Date : 2018-10-01 ,DOI:10.1021/acsnano.8b00966
Here, we explored an advanced hybrid lipid polymer shell mRNA nanoparticle (lipopolyplex) endowed with a trimannose sugar tree as an alternative delivery vehicle for systemic mRNA vaccination. ...
Probing the Growth Kinetics for the Formation of Uniform 1D Block Copolymer Nanoparticles by Living Crystallization-Driven Self-Assembly
ACS Nano (IF 13.903) Pub Date : 2018-09-12 ,DOI:10.1021/acsnano.8b01353
However, the factors that influence the rate of nanoparticle growth have not been systematically studied. ...
A Robust Liposomal Platform for Direct Colorimetric Detection of Sphingomyelinase Enzyme and Inhibitors
ACS Nano (IF 13.903) Pub Date : 2018-08-06 ,DOI:10.1021/acsnano.8b03308
Herein, SMase-triggered release of cysteine from a sphingomyelin (SM)-based liposome formulation with 60 mol % cholesterol causes gold nanoparticle (AuNP) aggregation, enabling colorimetric detection of SMase activities as low as 0.02 mU/mL, corresponding to 1.4 pM concentration. ...
Fluorinated Gold Nanoparticles for Nanostructure Imaging Mass Spectrometry
ACS Nano (IF 13.903) Pub Date : 2018-07-06 ,DOI:10.1021/acsnano.8b02376
Nanostructure imaging mass spectrometry (NIMS) with fluorinated gold nanoparticles (f-AuNPs) is a nanoparticle assisted laser desorption/ionization approach that requires low laser energy and has demonstrated high sensitivity. ...
Ultrafast Nanoscale Raman Thermometry Proves Heating Is Not a Primary Mechanism for Plasmon-Driven Photocatalysis
ACS Nano (IF 13.903) Pub Date : 2018-06-08 ,DOI:10.1021/acsnano.8b01809
Using an ultrafast surface-enhanced Raman thermometry technique, we probe the effective temperature, equivalent to the mode-specific increase of vibrational kinetic energy, of molecules adsorbed to gold nanoparticle aggregates in the most active hot spots on the picosecond time scale of chemical reactivity ...
Self-Assembling Myristoylated Human α-Defensin 5 as a Next-Generation Nanobiotics Potentiates Therapeutic Efficacy in Bacterial Infection
ACS Nano (IF 13.903) Pub Date : 2018-06-08 ,DOI:10.1021/acsnano.7b09109
Here, we describe a strategy for inducing the self-assembly of a host-defense antimicrobial peptide (AMP) into nanoparticle antibiotics (termed nanobiotics) with significantly improved pharmacological properties. ...
Digital Microarrays: Single-Molecule Readout with Interferometric Detection of Plasmonic Nanorod Labels
ACS Nano (IF 13.903) Pub Date : 2018-05-21 ,DOI:10.1021/acsnano.8b02036
By combining single-nanoparticle enumeration and ensemble measurements of spots when the particles are very dense, this system achieves a dynamic range of about 6 orders of magnitude directly from a single scan. ...
Magnetic Manipulation of Reversible Nanocaging Controls In Vivo Adhesion and Polarization of Macrophages
ACS Nano (IF 13.903) Pub Date : 2018-05-22 ,DOI:10.1021/acsnano.8b02226
We first conjugated a RGD-bearing gold nanoparticle (GNP) to the substrate and then a magnetic nanocage (MNC) to the GNP via a flexible linker to form the heterodimeric nanostructure. ...
Magnetic Particle Imaging-Guided Heating in Vivo Using Gradient Fields for Arbitrary Localization of Magnetic Hyperthermia Therapy
ACS Nano (IF 13.903) Pub Date : 2018-03-28 ,DOI:10.1021/acsnano.8b00893
The same superparamagnetic iron oxide nanoparticle (SPIONs) tracers imaged in MPI can also be excited to generate heat for magnetic hyperthermia. ...
Light-Activated Core–Shell Nanoparticles for Spatiotemporally Specific Treatment of Metastatic Triple-Negative Breast Cancer
ACS Nano (IF 13.903) Pub Date : 2018-02-22 ,DOI:10.1021/acsnano.7b09210
Here, we report a 78 nm, chlorin e6-, docetaxel-, and anti-Twist siRNA-containing polymeric nanoparticle(CDTN) with spatiotemporally specific activity when irradiated by light. ...
Janus Nanoparticle Structural Motif Control via Asymmetric Cation Exchange in Edge-Protected Cu1.81S@IrxSy Hexagonal Nanoplates
ACS Nano (IF 13.903) Pub Date : 2018-08-16 ,DOI:10.1021/acsnano.8b02752
Post-synthetic transformation of nanoparticles has received great attention, because this approach can provide an unusual route to elaborately composition-controlled nanostructures while maintaining the overall structure of the template. In principle, anisotropic heteronanoparticles of semiconductor materials can be synthesized via localized, that is, single site, cation exchange in symmetric nanoparticles. However, the differentiation of multiple identical cation exchange sites in symmetric nanoparticles can be difficult to achieve, especially for semiconductor systems with very fast cation exchange kinetics. We posited that single-site cation exchange in semiconductor nanoparticles might be realized by imposing a significant kinetic hurdle to the cation exchange reaction. The different atomic arrangements of the core and crown in core-crown structures might further differentiate the surface energies of originally identical cation exchange sites, leading to different reactivities of these sites. The first cation exchange site would be highly reactive due to the presence of a formed interface, thereby continuing to act as a site for cation exchange propagation. Herein, we present the proof-of-concept synthesis of Janus nanoparticles by using edge-protected Cu1.81S@IrxSy hexagonal nanoplates. The Janus nanoparticles comprising {Au2S-Cu1.81S}@IrxSy or {PdS-Cu1.81S}@IrxSy exhibited dissimilar structural motifs due to the disparate cation exchange directions. This synthetic methodology exploiting cation exchange of surface-passivated semiconductor nanoparticles could fabricate the numerous symmetry-controlled Janus heterostructures. ...
Nanoparticle-Assisted Transcutaneous Delivery of a Signal Transducer and Activator of Transcription 3-Inhibiting Peptide Ameliorates Psoriasis-like Skin Inflammation
ACS Nano (IF 13.903) Pub Date : 2018-06-27 ,DOI:10.1021/acsnano.8b02330
Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in psoriatic skin inflammation and acts as a key player in the pathogenesis and progression of this autoimmune disease. Although numerous inhibitors that intervene in STAT3-associated pathways have been tested, an effective, highly specific inhibitor of STAT3 has yet to be identified. Here, we evaluated the in vitro and in vivo biological activity and therapeutic efficacy of a high-affinity peptide specific for STAT3 (APTstat3) after topical treatment via intradermal and transcutaneous delivery. Using a preclinical model of psoriasis, we show that intradermal injection of APTstat3 tagged with a 9-arginine cell-penetrating peptide (APTstat3-9R) reduced disease progression and modulated psoriasis-related cytokine signaling through inhibition of STAT3 phosphorylation. Furthermore, by complexing APTstat3-9R with specific lipid formulations led to formation of discoidal lipid nanoparticles (DLNPs), we were able to achieve efficient skin penetration of the STAT3-inhibiting peptide after transcutaneous administration, thereby effectively inhibiting psoriatic skin inflammation. Collectively, these findings suggest that DLNP-assisted transcutaneous delivery of a STAT3-inhibiting peptide could be a promising strategy for treating psoriatic skin inflammation without causing adverse systemic events. Moreover, the DLNP system could be used for transdermal delivery of other therapeutic peptides. ...
Glutathione-Responsive Prodrug Nanoparticles for Effective Drug Delivery and Cancer Therapy
ACS Nano (IF 13.903) Pub Date : 2018-12-04 ,DOI:10.1021/acsnano.8b06400
The construction of a self-assembled nanoparticle (NP) platform, composed of amphiphilic lipid-polyethylene glycol (PEG) for effective delivery of Pt(IV) prodrugs capable of resisting thiol-mediated detoxification through a glutathione (GSH)-exhausting effect, offers a promising route to synergistically ...
Acidity/Reducibility Dual-Responsive Hollow Mesoporous Organosilica Nanoplatforms for Tumor-Specific Self-Assembly and Synergistic Therapy
ACS Nano (IF 13.903) Pub Date : 2018-11-15 ,DOI:10.1021/acsnano.8b06058
Featured with a large surface area, uniform interpenetrating mesopores, diverse organic framework hybridization, and well-defined surface properties, the hollow mesoporous organosilica nanoparticle(HMON) represents a promising paradigm in drug delivery systems with excellent biocompatibility. ...
Magnetic Targeting, Tumor Microenvironment-Responsive Intelligent Nanocatalysts for Enhanced Tumor Ablation
ACS Nano (IF 13.903) Pub Date : 2018-10-25 ,DOI:10.1021/acsnano.8b05042
The magnetic nanoparticle core of iron carbide-glucose oxidase (Fe5C2-GOD) achieved by physical absorption has a high enzyme payload, and the manganese dioxide (MnO2) nanoshell as an intelligent “gatekeeper” shields GOD from premature leaking until reaching tumor tissue. ...
Two-Dimensional MoS2 Confined Co(OH)2 Electrocatalysts for Hydrogen Evolution in Alkaline Electrolytes
ACS Nano (IF 13.903) Pub Date : 2018-04-24 ,DOI:10.1021/acsnano.8b00942
In this paper we report the design and synthesis of a two-dimensional (2D) MoS2 confined Co(OH)2 nanoparticle electrocatalyst, which accelerates water dissociation and exhibits good durability in alkaline solutions, leading to significant improvement in HER performance. ...
Drug Combination Synergy in Worm-like Polymeric Micelles Improves Treatment Outcome for Small Cell and Non-Small Cell Lung Cancer
ACS Nano (IF 13.903) Pub Date : 2018-03-16 ,DOI:10.1021/acsnano.7b07878
Nanoparticle-based systems for concurrent delivery of multiple drugs can improve outcomes of cancer treatments, but face challenges because of differential solubility and fairly low threshold for incorporation of many drugs. ...
Modulating Phagocytic Cell Sequestration by Tailoring Nanoconstruct Softness
ACS Nano (IF 13.903) Pub Date : 2018-01-16 ,DOI:10.1021/acsnano.7b07797
The effect of nanoparticle size, shape, and surface properties on cellular uptake has been extensively investigated for its basic science and translational implications. ...
Nanoparticle-Mediated Trapping of Wnt Family Member 5A in Tumor Microenvironments Enhances Immunotherapy for B-Raf Proto-Oncogene Mutant Melanoma
ACS Nano (IF 13.903) Pub Date : 2018-01-31 ,DOI:10.1021/acsnano.7b07384
Development of an effective treatment against advanced tumors remains a major challenge for cancer immunotherapy. Approximately 50% of human melanoma is driven by B-Raf proto-oncogene mutation (BRAF mutant). Tumors with such mutation are desmoplastic, highly immunosuppressive, and often resistant to immune checkpoint therapies. We have shown that immunotherapy mediated by low-dose doxorubicin-induced immunogenic cell death was only partially effective for this type of tumor and not effective in long-term inhibition of tumor progression. Wnt family member 5A (Wnt5a), a signaling protein highly produced by BRAF mutant melanoma cells, has been implicated in inducing dendritic cell tolerance and tumor fibrosis, thus hindering effective antigen presentation and T-cell infiltration. We hypothesized that Wnt5a is a key molecule controlling the immunosuppressive tumor microenvironment in metastatic melanoma. Accordingly, we have designed and generated a trimeric trap protein, containing the extracellular domain of Fizzled 7 receptor that binds Wnt5a with a Kd ∼ 278 nM. Plasmid DNA encoding for the Wnt5a trap was delivered to the tumor by using cationic lipid-protamine-DNA nanoparticles. Expression of Wnt5a trap in the tumor, although transient, was greater than that of any other major organs including liver, resulting in a significant reduction of the Wnt5a level in the tumor microenvironment without systematic toxicity. Significantly, combination of Wnt5a trapping and low-dose doxorubicin showed great tumor growth inhibition and host survival prolongation. Our findings indicated that efficient local Wnt5a trapping significantly remodeled the immunosuppressive tumor microenvironment to facilitate immunogenic cell-death-mediated immunotherapy. ...
A Highly-Efficient Single Segment White Random Laser
ACS Nano (IF 13.903) Pub Date : 2018-10-26 ,DOI:10.1021/acsnano.8b03035
The multiple scatterings arising from the inherent nature of the disordered nanoparticle matrix provide a convenient way for the formation of closed feedback loops, which is beneficial for the coherent laser action. ...
Thin Nacre-Biomimetic Coating with Super-Anticorrosion Performance
ACS Nano (IF 13.903) Pub Date : 2018-09-17 ,DOI:10.1021/acsnano.8b05183
The 5NBGE coating exhibited better performance than carbon-based nanoparticle/epoxy mixed coatings. ...
Improved Efficacy and Reduced Toxicity Using a Custom-Designed Irinotecan-Delivering Silicasome for Orthotopic Colon Cancer
ACS Nano (IF 13.903) Pub Date : 2018-12-11 ,DOI:10.1021/acsnano.8b06164
Our goal was to custom design a mesoporous silica nanoparticle (MSNP) carrier for encapsulated irinotecan delivery in a robust CRC model. This was achieved by developing an orthotopic tumor chunk model in immunocompetent mice. ...
Biocompatible Peptide-Coated Ultrasmall Superparamagnetic Iron Oxide Nanoparticles for In Vivo Contrast-Enhanced Magnetic Resonance Imaging
ACS Nano (IF 13.903) Pub Date : 2018-07-11 ,DOI:10.1021/acsnano.7b07572
The quality of the surface coating of nanoparticle-based MRI contrast agents, such as ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs), is critical to ensure high colloidal stability in biological environments, improved magnetic performance, and dispersion in circulatory fluids and tissues ...
 
 

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