纳米医学网
首页  |  关于我们  |   加入收藏  |  留言反馈
当前位置:首页 >
2019年生物纳米研究最新热点报道(一)
来源于:纳米医学网 | 作者: | 发布时间:2017-11-25 | 浏览:325



High-Resolution Nanoparticle Sizing with Maximum A Posteriori Nanoparticle Tracking Analysis
ACS Nano (IF 13.903) Pub Date : 2019-03-25 ,DOI:10.1021/acsnano.8b07215
Modern algorithms such as MApNTA should find widespread use in the routine characterization of complex nanoparticle dispersions, allowing for significant advances in nanoparticle synthesis, separation, and functionalization. ...
Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices
ACS Nano (IF 13.903) Pub Date : 2019-04-08 ,DOI:10.1021/acsnano.9b01294
DNA-mediated self-assembly of nanoparticles has been of great interest because it enables access to nanoparticle superstructures that cannot be synthesized otherwise. However, the programmability of higher order nanoparticle structures can be easily lost under DNA denaturing conditions. ...
Vasodilator Hydralazine Promotes Nanoparticle Penetration in Advanced Desmoplastic Tumors
ACS Nano (IF 13.903) Pub Date : 2019-01-17 ,DOI:10.1021/acsnano.8b07830
Using DiD-loaded liposome as a model nanoparticle, we showed that HDZ–liposome treatment significantly increased nanoparticle accumulation and penetration inside desmoplastic tumors. ...
Meta-Analysis of Nanoparticle Cytotoxicity via Data-Mining the Literature
ACS Nano (IF 13.903) Pub Date : 2019-01-31 ,DOI:10.1021/acsnano.8b07562
Among several influential attributes, we show that the cytotoxicity of nanoparticles is primarily predicted from the nanoparticle material chemistry, followed by nanoparticle concentration and size, cell type, and cytotoxicity screening indicator. ...
Role of Nanoparticle Mechanical Properties in Cancer Drug Delivery
ACS Nano (IF 13.903) Pub Date : 2019-07-11 ,DOI:10.1021/acsnano.9b03924
Whereas the effects of the size, shape, and surface charge of nanoparticles on their biological performances have been extensively investigated, the roles of nanoparticle mechanical properties in drug delivery, which have only been recognized recently, remain the least explored. ...
Well-Ordered Inorganic Nanoparticle Arrays Directed by Block Copolymer Nanosheets
ACS Nano (IF 13.903) Pub Date : 2019-05-30 ,DOI:10.1021/acsnano.9b00940
This technique can be used to generate nanoparticle arrays with various nanoparticle arrangements, including hexagonal honeycomb structures, periodic nanoring structures, and their combinations. ...
Refocusing in Situ Electron Microscopy: Moving beyond Visualization of Nanoparticle Self-Assembly To Gain Practical Insights into Advanced Material Fabrication
ACS Nano (IF 13.903) Pub Date : 2019-11-18 ,DOI:10.1021/acsnano.9b08281
Despite incredible progress in preparing extended nanoparticle superlattices by self-assembly, theoretically predicted collective properties of extended nanoparticle superlattices are rarely correlated to observations due to the presence of defects. ...
Orally Administrable Therapeutic Synthetic Nanoparticle for Zika Virus
ACS Nano (IF 13.903) Pub Date : 2019-10-11 ,DOI:10.1021/acsnano.9b02807
For potential clinical relevance, long-term storable formulation of IVM-nanoparticle in dry powder state for inclusion in a capsule form and cryoprotectant containing frozen forms revealed promising findings. ...
Regulation of Cell Uptake and Cytotoxicity by Nanoparticle Core under the Controlled Shape, Size, and Surface Chemistries
ACS Nano (IF 13.903) Pub Date : 2019-12-26 ,DOI:10.1021/acsnano.9b04407
Our results demonstrate that nanoparticle core material is as important as other structural parameters in nanoparticle–cell interactions, making it also a necessary consideration when designing nanomedicines. ...
Cross-Correlative Single-Cell Analysis Reveals Biological Mechanisms of Nanoparticle Radiosensitization
ACS Nano (IF 13.903) Pub Date : 2019-04-29 ,DOI:10.1021/acsnano.8b07982
Nanoparticle radiosensitization has been demonstrated well to enhance the effects of radiotherapy, motivate the improvement of therapeutic ratios, and decrease morbidity in cancer treatment. ...
Molecular Signature of Asthma-Enhanced Sensitivity to CuO Nanoparticle Aerosols from 3D Cell Model
ACS Nano (IF 13.903) Pub Date : 2019-06-17 ,DOI:10.1021/acsnano.9b01823
Gene expression changes between nanoparticle-exposed versus air-exposed cells were investigated. ...
Photo-organometallic, Nanoparticle Nucleation on Graphene for Cascaded Doping
ACS Nano (IF 13.903) Pub Date : 2019-10-17 ,DOI:10.1021/acsnano.9b05484
This nanoparticle-on-graphene construct can have several applications in gas/vapor sensing, electrochemical catalysis, and high-energy-density supercapacitors. ...
Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy
ACS Nano (IF 13.903) Pub Date : 2019-07-10 ,DOI:10.1021/acsnano.8b08875
Our findings shed light on natural limitations of nanoparticle accumulation in atherosclerotic plaques and provide mechanistic insight into nanoparticle trafficking across the atherosclerotic endothelium. ...
Nanoparticle–Hydrogel System for Post-myocardial Infarction Delivery of MicroRNA
ACS Nano (IF 13.903) Pub Date : 2019-08-30 ,DOI:10.1021/acsnano.9b05716
In this Perspective, we summarize different mechanisms for miR administration and localization to cardiac tissue, with a specific focus on the clinically relevant injectable hydrogel and nanoparticle system developed by Yang et al. and reported in this issue of ACS Nano. ...
Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy
ACS Nano (IF 13.903) Pub Date : 2019-03-27 ,DOI:10.1021/acsnano.8b08177
In this study, we developed a cyclic peptide iRGD (CCRGDKGPDC)-conjugated solid lipid nanoparticle(SLN) to deliver small interfering RNAs (siRNAs) against both epidermal growth factor receptor (EGFR) and PD-L1 for combined targeted and immunotherapy against glioblastoma, the most aggressive type of ...
Probing and Controlling Dynamic Interactions at Biomolecule–Nanoparticle Interfaces Using Stochastic DNA Walkers
ACS Nano (IF 13.903) Pub Date : 2019-06-26 ,DOI:10.1021/acsnano.9b03053
The improved understanding of the bio–nano interface may facilitate better design and operation of nanoparticle-based biosensors and/or functional devices. ...
Analysis of the Limits of the Near-Field Produced by Nanoparticle Arrays
ACS Nano (IF 13.903) Pub Date : 2019-09-11 ,DOI:10.1021/acsnano.9b05031
As a direct application of our results, we investigate the interaction between a nanoparticle array and a dielectric slab placed a certain distance above it and show that the extraordinary near-field enhancement produced by the lattice resonance can lead to very strong interactions, even at significantly ...
Chiral Plasmons: Au Nanoparticle Assemblies on Thermoresponsive Organic Templates
ACS Nano (IF 13.903) Pub Date : 2019-04-04 ,DOI:10.1021/acsnano.8b09624
By taking these strategies a step forward, herein we report the design of two chiral plasmonic nanostructures based on Au nanoparticle (NP) assemblies organized in clockwise and anticlockwise directions, having opposite response to circularly polarized light. ...
Presentation and Delivery of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand via Elongated Plant Viral Nanoparticle Enhances Antitumor Efficacy
ACS Nano (IF 13.903) Pub Date : 2019-01-22 ,DOI:10.1021/acsnano.8b09462
TRAIL bound to PVX by coordination bonds between nickel-coordinated nitrilotriacetic acid on PVX and His-tag on the protein could mimic the bioactive “membrane-bound” state in native TRAIL, resulting in an elongated nanoparticle displaying up 490 therapeutic protein molecules. ...
Uniaxial Deformation and Crazing in Glassy Polymer-Grafted Nanoparticle Ultrathin Films
ACS Nano (IF 13.903) Pub Date : 2019-10-21 ,DOI:10.1021/acsnano.9b05001
The deformation behavior of neat, glassy polymer-grafted nanoparticle (PGN) monolayer films is studied using coarse-grained molecular dynamics simulations and experiments on polystyrene-grafted silica. ...
Mucosal Immunization with a pH-Responsive Nanoparticle Vaccine Induces Protective CD8+ Lung-Resident Memory T Cells
ACS Nano (IF 13.903) Pub Date : 2019-10-04 ,DOI:10.1021/acsnano.9b00326
Here, we describe a pH-responsive polymeric nanoparticle vaccine for generating antigen-specific CD8+ TRM cells in the lungs. ...
An Upconversion Nanoparticle Enables Near Infrared-Optogenetic Manipulation of the Caenorhabditis elegans Motor Circuit
ACS Nano (IF 13.903) Pub Date : 2019-01-29 ,DOI:10.1021/acsnano.8b09270
We designed and synthesized a Yb3+/Er3+/Ca2+-based lanthanide-doped upconversion nanoparticle(UCNP) that effectively converts 808 nm NIR light to green light emission. ...
Detection of Premalignant Gastrointestinal Lesions Using Surface-Enhanced Resonance Raman Scattering–Nanoparticle Endoscopy
ACS Nano (IF 13.903) Pub Date : 2019-02-04 ,DOI:10.1021/acsnano.8b06808
Here we report our finding that a single dose of a high-sensitivity surface-enhanced resonance Raman scattering nanoparticle (SERRS-NP) enables reliable detection of precancerous GI lesions in animal models that closely mimic disease development in humans. ...
Enhanced Primary Tumor Penetration Facilitates Nanoparticle Draining into Lymph Nodes after Systemic Injection for Tumor Metastasis Inhibition
ACS Nano (IF 13.903) Pub Date : 2019-07-22 ,DOI:10.1021/acsnano.9b03472
Here, we uncovered that improved perfusion in a primary tumor facilitates nanoparticle translocation to LNs for inhibiting tumor metastasis. ...
Nanoparticle Size and Coating Chemistry Control Foliar Uptake Pathways, Translocation, and Leaf-to-Rhizosphere Transport in Wheat
ACS Nano (IF 13.903) Pub Date : 2019-05-16 ,DOI:10.1021/acsnano.8b09781
However, limited understanding about how nanoparticle properties influence their interactions with plant leaves, uptake, translocation through the mesophyll to the vasculature, and transport to the rest of the plant prevents rational design. ...
Supercharging Superlocalization Microscopy: How Electrochemical Charging of Plasmonic Nanostructures Uncovers Hidden Heterogeneity
ACS Nano (IF 13.903) Pub Date : 2019-06-05 ,DOI:10.1021/acsnano.9b04062
In many of these applications, the superlocalized position of the nanoparticle is assumed to correspond to the geometric center of the nanoparticle. ...
The Skin You Are In: Design-of-Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants
ACS Nano (IF 13.903) Pub Date : 2019-05-03 ,DOI:10.1021/acsnano.9b01774
Using DoE inputs of complexing lipid identity, lipid nanoparticle dose, lipid concentration, particle concentration, and ratio of zwitterionic to cationic lipids, we optimized the saRNA-induced luciferase expression in skin explants. ...
A MnO2 Nanoparticle-Dotted Hydrogel Promotes Spinal Cord Repair via Regulating Reactive Oxygen Species Microenvironment and Synergizing with Mesenchymal Stem Cells
ACS Nano (IF 13.903) Pub Date : 2019-12-02 ,DOI:10.1021/acsnano.9b07598
Herein, a MnO2 nanoparticle (NP)-dotted hydrogel is prepared through dispersion of MnO2 NPs in a PPFLMLLKGSTR peptide modified hyaluronic acid hydrogel. The peptide-modified hydrogel enables the adhesive growth of mesenchymal stem cells (MSCs) and nerve tissue bridging. ...
Supervised Learning and Mass Spectrometry Predicts the in Vivo Fate of Nanomaterials
ACS Nano (IF 13.903) Pub Date : 2019-07-03 ,DOI:10.1021/acsnano.9b02774
How this interface changes during circulation and its impact on nanoparticle distribution within the body is not understood. Here, we developed a workflow to show that the evolution of proteins on nanoparticlesurfaces predicts the biological fate of nanoparticles in vivo. ...
Kinetic Control in Assembly of Plasmid DNA/Polycation Complex Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2019-09-10 ,DOI:10.1021/acsnano.9b03334
This achieves explicit control of the kinetic conditions for pDNA/lPEI nanoparticle assembly, as demonstrated by the tunability of nanoparticle size, composition, and pDNA payload. ...
Electrotunable Nanoplasmonics for Amplified Surface Enhanced Raman Spectroscopy
ACS Nano (IF 13.903) Pub Date : 2019-12-16 ,DOI:10.1021/acsnano.9b05257
In such a system, the density of the nanoparticle array can be reversibly controlled by the variation of electrode potential. ...
A Three-Dimensional Cell Culture Platform for Long Time-Scale Observations of Bio–Nano Interactions
ACS Nano (IF 13.903) Pub Date : 2019-11-07 ,DOI:10.1021/acsnano.9b07453
Long-term in vitro nanoparticle studies are hampered by a lack of suitable models, as standard cell culture techniques present several drawbacks, while technical limitations render current three-dimensional (3D) cellular spheroid models less suited. ...
Nanoparticles for Oral Biofilm Treatments
ACS Nano (IF 13.903) Pub Date : 2019-04-29 ,DOI:10.1021/acsnano.9b02816
Nanoparticle-mediated eradication of the biofilm matrix and resident bacteria holds great potential. In particular, nanoparticles that target specific microbial and biofilm features utilizing nontoxic materials are well-suited for clinical translation. ...
Polarization-Dependent Lasing Behavior from Low-Symmetry Nanocavity Arrays
ACS Nano (IF 13.903) Pub Date : 2019-04-08 ,DOI:10.1021/acsnano.9b01142
This paper reports how geometric effects in low-symmetry plasmonic nanoparticle arrays can produce polarization-dependent lasing responses. ...
Increasing the Efficacy of Stem Cell Therapy via Triple-Function Inorganic Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2019-06-17 ,DOI:10.1021/acsnano.9b00653
In vivo rodent studies show that labeling stem cells with this nanoparticle increased the efficacy of stem cell therapy in a ligation/reperfusion model. ...
In Situ Plasmonic Nanospectroscopy of the CO Oxidation Reaction over Single Pt Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2019-05-17 ,DOI:10.1021/acsnano.9b02876
We find that the reaction kinetics of simultaneously measured individual Pt model catalysts are dictated by the grain structure and that the superposition of the individual nanoparticle response can account for the significant broadening observed in the corresponding nanoparticle ensemble data. ...
Atomistic Origin of the Complex Morphological Evolution of Aluminum Nanoparticles during Oxidation: A Chain-like Oxide Nucleation and Growth Mechanism
ACS Nano (IF 13.903) Pub Date : 2019-02-22 ,DOI:10.1021/acsnano.8b07633
In this work, we have found and investigated the chain-like nucleation and growth of oxides on the aluminum nanoparticle (ANP) surface, using molecular dynamics simulations with the reactive force-field (ReaxFF). ...
Controlling Crystal Texture in Programmable Atom Equivalent Thin Films
ACS Nano (IF 13.903) Pub Date : 2019-07-08 ,DOI:10.1021/acsnano.9b04333
DNA is a powerful tool in the directed assembly of nanoparticle based superlattice materials, as the predictable nature of Watson–Crick base pairing allows DNA-grafted particles to be programmably assembled into unit cells that arise from the complete control of nanoparticle coordination environment ...
A General Approach to Free-Standing Nanoassemblies via Acoustic Levitation Self-Assembly
ACS Nano (IF 13.903) Pub Date : 2019-04-15 ,DOI:10.1021/acsnano.8b09628
This strategy has no limitation for the sizes or shapes of constituent metallic nanoparticle building blocks and can also be applied to fabricate free-standing bilayered and trilayered nanoassemblies or even three-dimensional hollow nanoassemblies. ...
Massively Parallel Nanoparticle Synthesis in Anisotropic Nanoreactors
ACS Nano (IF 13.903) Pub Date : 2019-10-15 ,DOI:10.1021/acsnano.9b05781
This work reports a massively parallel approach for synthesizing inorganic nanoparticles (Au, Ag, Se, and mixed oxides of Cu, Co, Ni, Ge, and Ta) based upon lithographically generated arrays of square pyramidal nanoholes, which serve as nanoreactors. Particle precursor-containing polymers are spin-coated onto the nanoreactors, which upon dewetting generate a morphology of isolated polymer droplets in each nanoreactor. This dewetting process yields a well-defined and precisely controlled volume of polymer and therefore particle precursor in each nanoreactor. Subsequent stepwise annealing (first at 150 °C and then at 500 °C) yields arrays of monodisperse, site-isolated particles with sub-5 nm position control. By varying the precursor loading of the polymer, particle size can be systematically controlled in the 7–30 nm range. This work not only introduces the concept of merging block copolymer inks with nanohole arrays in the synthesis of nanoparticles but also underscores the value of the nanoreactor shape in controlling resulting particle position. ...
Reduction of Nanoparticle Load in Cells by Mitosis but Not Exocytosis
ACS Nano (IF 13.903) Pub Date : 2019-07-11 ,DOI:10.1021/acsnano.9b01604
The long-term fate of biomedically relevant nanoparticles (NPs) at the single cell level after uptake is not fully understood yet. We report that lysosomal exocytosis of NPs is not a mechanism to reduce the particle load. Biopersistent NPs such as nonporous silica and gold remain in cells for a prolonged time. The only reduction of the intracellular NP number is observed via cell division, e.g., mitosis. Additionally, NP distribution after cell division is observed to be asymmetrical, likely due to the inhomogeneous location and distribution of the NP-loaded intracellular vesicles in the mother cells. These findings are important for biomedical and hazard studies as the NP load per cell can vary significantly. Furthermore, we highlight the possibility of biopersistent NP accumulation over time within the mononuclear phagocyte system. ...
Interfacial Assembly of Tunable Anisotropic Nanoparticle Architectures
ACS Nano (IF 13.903) Pub Date : 2019-03-25 ,DOI:10.1021/acsnano.8b08733
We propose a strategy for assembling spherical nanoparticles (NPs) into anisotropic architectures in a polymer matrix. The approach takes advantage of the interfacial tension between two mutually immiscible polymers forming a bilayer and differences in the compatibility of the two polymer layers with polymer grafts on particles to trap NPs within two-dimensional planes parallel to the interface. The ability to precisely tune the location of the entrapment planes via the NP grafting density, and to trap multiple interacting particles within distinct planes, can then be used to assemble NPs into unconventional arrangements near the interface. We carry out molecular dynamics simulations of polymer-grafted NPs in a polymer bilayer to demonstrate the viability of the proposed approach in both trapping NPs at tunable distances from the interface and assembling them into a variety of unusual nanostructures. We illustrate the assembly of NP clusters, such as dimers with tunable tilt relative to the interface and trimers with tunable bending angle, as well as anisotropic macroscopic phases, including serpentine and branched structures, ridged hexagonal monolayers, and square-ordered bilayers. We also develop a theoretical model to predict the preferred positions and free energies of NPs trapped at or near the interface that could help guide the design of polymer-grafted NPs for achieving target NP architectures. Overall, this work suggests that interfacial assembly of NPs could be a promising approach for fabricating next-generation polymer nanocomposites with potential applications in plasmonics, electronics, optics, and catalysis where precise arrangement of polymer-embedded NPs is required for function. ...
Chondroitin Sulfate-Linked Prodrug Nanoparticles Target the Golgi Apparatus for Cancer Metastasis Treatment
ACS Nano (IF 13.903) Pub Date : 2019-08-06 ,DOI:10.1021/acsnano.9b04166
This multistep targeted nanoparticle system potentially enhanced the effect of antimetastasis combined with chemotherapy. ...
Tracking Sub-Nanometer Shift in the Scattering Centroid of Single Gold Nanorods during Electrochemical Charging
ACS Nano (IF 13.903) Pub Date : 2019-04-18 ,DOI:10.1021/acsnano.8b09636
While conventional wisdom suggests the scattering centroid of a plasmonic nanoparticle reflects its geometric center, here we uncover the dependence of a scattering centroid of a single gold nanorod (AuNR) on its electron density when the geometric features (position and morphology) do not change at ...
Arrays of Plasmonic Nanoparticle Dimers with Defined Nanogap Spacers
ACS Nano (IF 13.903) Pub Date : 2019-09-25 ,DOI:10.1021/acsnano.9b04938
Plasmonic molecules are building blocks of metallic nanostructures that give rise to intriguing optical phenomena with similarities to those seen in molecular systems. The ability to design plasmonic hybrid structures and molecules with nanometric resolution would enable applications in optical metamaterials and sensing that presently cannot be demonstrated, because of a lack of suitable fabrication methods allowing the structural control of the plasmonic atoms on a large scale. Here we demonstrate a wafer-scale “lithography-free” parallel fabrication scheme to realize nanogap plasmonic meta-molecules with precise control over their size, shape, material, and orientation. We demonstrate how we can tune the corresponding coupled resonances through the entire visible spectrum. Our fabrication method, based on glancing angle physical vapor deposition with gradient shadowing, permits critical parameters to be varied across the wafer and thus is ideally suited to screen potential structures. We obtain billions of aligned dimer structures with controlled variation of the spectral properties across the wafer. We spectroscopically map the plasmonic resonances of gold dimer structures and show that they not only are in good agreement with numerically modeled spectra, but also remain functional, at least for a year, in ambient conditions. ...
Elimination Pathways of Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2019-04-26 ,DOI:10.1021/acsnano.9b01383
Many promising nanoparticle formulations for in vivo medical applications are large (>5.5 nm) and nonbiodegradable, so they cannot be eliminated renally. A proposed pathway for these nanoparticles is hepatobiliary elimination, but their transport has not been well-studied. ...
High-Performance Chromatographic Characterization of Surface Chemical Heterogeneities of Fluorescent Organic–Inorganic Hybrid Core–Shell Silica Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2019-01-10 ,DOI:10.1021/acsnano.8b07876
Because surface chemical properties are key to all nanoparticle interactions, we expect these methods and fundamental insights to become relevant to a number of systems for applications, including bioimaging and nanomedicine. ...
In Situ Nanoadjuvant-Assembled Tumor Vaccine for Preventing Long-Term Recurrence
ACS Nano (IF 13.903) Pub Date : 2019-06-14 ,DOI:10.1021/acsnano.9b02071
To mimic the tumor microenvironment, we cocultured bone marrow-derived dendritic cells with CT26 cells treated with various nanoparticle formulations and NIR irradiated. ...
Predicting the Time of Entry of Nanoparticles in Lipid Membranes
ACS Nano (IF 13.903) Pub Date : 2019-09-13 ,DOI:10.1021/acsnano.9b03434
The model identifies four parameters that separate the contributions of nanoparticle characteristics (i.e., size, shape, solubility) from the membrane properties (density distribution). ...
Synergistic Energy Nanoconfinement and Water Activation in Hydrogels for Efficient Solar Water Desalination
ACS Nano (IF 13.903) Pub Date : 2019-07-02 ,DOI:10.1021/acsnano.9b02301
Here, we report a light-absorbing sponge-like hydrogel (LASH) that is created by in situ gelation of a light-absorbing nanoparticle-modified polymer, leading to synergistic energy nanoconfinement and water activation. ...
Quantifying Wavelength-Dependent Plasmonic Hot Carrier Energy Distributions at Metal/Semiconductor Interfaces
ACS Nano (IF 13.903) Pub Date : 2019-03-01 ,DOI:10.1021/acsnano.9b00219
Photocatalytic devices utilizing plasmonic hot carriers are often based on metal nanoparticle/semiconductor heterostructures owing to their efficient electron–hole separation ability. ...
Enhanced Tumor Synergistic Therapy by Injectable Magnetic Hydrogel Mediated Generation of Hyperthermia and Highly Toxic Reactive Oxygen Species
ACS Nano (IF 13.903) Pub Date : 2019-10-25 ,DOI:10.1021/acsnano.9b06134
Nanoparticle-mediated tumor magnetic induction hyperthermia has received tremendous attention. However, it has been a challenge to improve the efficacy at 42 °C therapeutic temperatures without resistance to induced thermal stress. ...
In Vivo Photoacoustic Tracking of Mesenchymal Stem Cell Viability
ACS Nano (IF 13.903) Pub Date : 2019-06-28 ,DOI:10.1021/acsnano.9b01802
This nanoparticle system allows for longitudinal tracking of MSC viability in vivo with high spatial and temporal resolution which other imaging modalities currently cannot achieve. ...
Oscillatory Viscoelastic Microfluidics for Efficient Focusing and Separation of Nanoscale Species
ACS Nano (IF 13.903) Pub Date : 2019-12-09 ,DOI:10.1021/acsnano.9b06123
To date, viscoelastic microfluidic systems have primarily been applied to the focusing, separation, and isolation of micrometer-sized species, with their use in nanoparticle manipulations being underdeveloped and underexplored, due to issues related to nanoparticle diffusivity and a need for extended ...
Overcoming the Reticuloendothelial System Barrier to Drug Delivery with a “Don’t-Eat-Us” Strategy
ACS Nano (IF 13.903) Pub Date : 2019-11-07 ,DOI:10.1021/acsnano.9b05679
Our study demonstrates a strategy that blocks the RES by masking phagocyte surfaces to prolong nanoparticle circulation time without excess modification and illustrates its utility in enhancing nanoparticle delivery. ...
Chiral Scatterometry on Chemically Synthesized Single Plasmonic Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2019-07-15 ,DOI:10.1021/acsnano.9b04046
Being intrinsically scalable, bottom-up nanoparticle synthesis shows an ever-growing control over particle morphology, enabling even chirally selective shapes. ...
High Co-loading Capacity and Stimuli-Responsive Release Based on Cascade Reaction of Self-Destructive Polymer for Improved Chemo-Photodynamic Therapy
ACS Nano (IF 13.903) Pub Date : 2019-06-12 ,DOI:10.1021/acsnano.9b02096
Ce6 is retained with DOX by a π–π stacking interaction, with high loading (41.9 wt %) and the optimal nanoparticle size (50 nm). ...
Effect of Airborne Hydrocarbons on the Wettability of Phase Change Nanoparticle Decorated Surfaces
ACS Nano (IF 13.903) Pub Date : 2019-10-22 ,DOI:10.1021/acsnano.9b06909
We present here a detailed study of the wettability of surfaces nanostructured with amorphous and crystalline nanoparticles (NPs) derived from the phase-change material Ge2Sb2Te5 (GST). Particular attention was devoted to the effect of airborne surface hydrocarbons on surface wetting. Our analysis illustrates that a reversible hydrophilic–hydrophobic wettability switch is revealed by combined ultraviolet-ozone (UV-O3) treatments and exposure to hydrocarbon atmospheres. Indeed, the as-prepared surfaces exhibited a hydrophilic state after thermal annealing or UV-O3 treatment which can partially remove hydrocarbon contaminants, while a hydrophobic state was realized after exposure to hydrocarbon atmosphere. Using high-angle annular dark-field scanning transmission electron microscopy for the specially designed GST NP decorated graphene substrates, a network of hydrocarbon connecting GST NPs was observed. Our findings indicate that airborne hydrocarbons can significantly enhance the hydrophobicity of nanostructured surfaces. Finally, the experiments reveal that previously defined hydrophilic materials can be used for the design of hydrophobic surfaces even if the meniscus is highly adhered to a solid surface, which is in agreement with our qualitative model involving the contribution of the nanomeniscus formed between the substrate and a decorating NP. ...
One-Pot Production of RNA Nanoparticles via Automated Processing and Self-Assembly
ACS Nano (IF 13.903) Pub Date : 2019-03-22 ,DOI:10.1021/acsnano.9b00649
In combination with the RNA nanoparticle construction process, a purification method using a large-scale electrophoresis column was also developed. ...
Microfluidics Assisted Fabrication of Three-Tier Hierarchical Microparticles for Constructing Bioinspired Surfaces
ACS Nano (IF 13.903) Pub Date : 2019-03-15 ,DOI:10.1021/acsnano.9b00245
The formation process and topologies of nanowrinkles can be regulated by the photopolymerization process and the fraction of carboxylic groups on the PS nanoparticle surface. Such a hierarchical microsphere mimics individual units of bioinspired surfaces. ...
Mussel-Inspired Self-Healing Metallopolymers for Silicon Nanoparticle Anodes
ACS Nano (IF 13.903) Pub Date : 2019-07-03 ,DOI:10.1021/acsnano.9b03837
Polymers with supramolecular functionality are receiving increasing attention for rechargeable battery binders as strong supramolecular interactions can facilitate self-healing effects via bond recovery of the cleaved cross-links. Such self-healing capability is useful for emerging high-capacity battery materials that undergo large volume changes. Benchmarking mussel’s sticky byssus cuticle, herein we report a copolymer binder with Fe3+–(tris)catechol coordination cross-links, which can induce a self-healing effect for silicon anodes. The high strength of the Fe3+–(tris)catechol coordination bond can lead to recovery of the dissociated bond that occurs from the large volume expansion of silicon. The given copolymer also contains monomer units with sufficient flexibility to increase the interchain motions for efficient Fe3+–(tris)catechol bond recovery. The superior electrochemical performance of the Si electrodes based on the proposed copolymer binder indicates that metallopolymers which utilize metal–organic ligand coordination for interchain cross-linking are promising binders with self-healing effects for sustainable cycling of high capacity battery electrodes. ...
Spatial, Temporal, and Dose Control of Drug Delivery using Noninvasive Magnetic Stimulation
ACS Nano (IF 13.903) Pub Date : 2019-01-18 ,DOI:10.1021/acsnano.8b06655
In this paper, we report a design using a stimuli-responsive nanoparticle platform to control the dosage of the cargo released by an alternating magnetic field (AMF) actuation. ...
Amorphous Tin Oxide Nanohelix Structure Based Electrode for Highly Reversible Na-Ion Batteries
ACS Nano (IF 13.903) Pub Date : 2019-05-14 ,DOI:10.1021/acsnano.8b09773
with a large surface area and high porosity, which facilitate Na-ion dynamics and accommodate the volume changes, enabled a reversible capacity of up to 915 mA h g–1 after 50 cycles, fast rate capability with 48.1% retention at 2 A g–1, and high stability, which are superior to those of crystalline nanoparticle-based ...
Lattice-Resonance Metalenses for Fully Reconfigurable Imaging
ACS Nano (IF 13.903) Pub Date : 2019-03-26 ,DOI:10.1021/acsnano.9b00651
For scalability, we demonstrated a simple technique for erasing and writing the polymer nanostructures on the metal nanoparticle arrays in a single step using solvent-assisted nanoscale embossing. ...
Dextran-Coated Iron Oxide Nanoparticles as Biomimetic Catalysts for Localized and pH-Activated Biofilm Disruption
ACS Nano (IF 13.903) Pub Date : 2019-01-22 ,DOI:10.1021/acsnano.8b08702
Mechanistic studies indicated that iron oxide cores are the source of catalytic activity, whereas dextran on the nanoparticle surface provided stability without blocking catalysis. ...
Nanoparticle-Based Hybrid Scaffolds for Deciphering the Role of Multimodal Cues in Cardiac Tissue Engineering
ACS Nano (IF 13.903) Pub Date : 2019-10-28 ,DOI:10.1021/acsnano.9b03050
Myocardial microenvironment plays a decisive role in guiding the function and fate of cardiomyocytes, and engineering this extracellular niche holds great promise for cardiac tissue regeneration. Platforms utilizing hybrid hydrogels containing various types of conductive nanoparticles have been a critical tool for constructing engineered cardiac tissues with outstanding mechanical integrity and improved electrophysiological properties. However, there has been no attempt to directly compare the efficacy of these hybrid hydrogels and decipher the mechanisms behind how these platforms differentially regulate cardiomyocyte behavior. Here, we employed gelatin methacryloyl (GelMA) hydrogels containing three different types of carbon-based nanoparticles: carbon nanotubes (CNTs), graphene oxide (GO), and reduced GO (rGO), to investigate the influence of these hybrid scaffolds on the structural organization and functionality of cardiomyocytes. Using immunofluorescent staining for assessing cellular organization and proliferation, we showed that electrically conductive scaffolds (CNT- and rGO-GelMA compared to relatively nonconductive GO-GelMA) played a significant role in promoting desirable morphology of cardiomyocytes and elevated the expression of functional cardiac markers, while maintaining their viability. Electrophysiological analysis revealed that these engineered cardiac tissues showed distinct cardiomyocyte phenotypes and different levels of maturity based on the substrate (CNT-GelMA: ventricular-like, GO-GelMA: atrial-like, and rGO-GelMA: ventricular/atrial mixed phenotypes). Through analysis of gene-expression patterns, we uncovered that the engineered cardiac tissues matured on CNT-GelMA and native cardiac tissues showed comparable expression levels of maturation markers. Furthermore, we demonstrated that engineered cardiac tissues matured on CNT-GelMA have increased functionality through integrin-mediated mechanotransduction (via YAP/TAZ) in contrast to cardiomyocytes cultured on rGO-GelMA. ...
Toward Real-Time Monitoring and Control of Single Nanoparticle Properties with a Microbubble Resonator Spectrometer
ACS Nano (IF 13.903) Pub Date : 2019-10-21 ,DOI:10.1021/acsnano.9b04702
Optical microresonators have widespread application at the frontiers of nanophotonic technology, driven by their ability to confine light to the nanoscale and enhance light–matter interactions. Microresonators form the heart of a recently developed method for single-particle photothermal absorption spectroscopy, whereby the microresonators act as microscale thermometers to detect the heat dissipated by optically pumped, nonluminescent nanoscopic targets. However, translation of this technology to chemically dynamic systems requires a platform that is mechanically stable, solution compatible, and visibly transparent. We report microbubble absorption spectrometers as a versatile platform that meets these requirements. Microbubbles integrate a two-port microfluidic device within a whispering gallery mode microresonator, allowing for the facile exchange of chemical reagents within the resonator’s interior while maintaining a solution-free environment on its exterior. We first leverage these qualities to investigate the photoactivated etching of single gold nanorods by ferric chloride, providing a method for rapid acquisition of spatial and morphological information about nanoparticles as they undergo chemical reactions. We then demonstrate the ability to control nanorod orientation within a microbubble through optically exerted torque, a promising route toward the construction of hybrid photonic-plasmonic systems. Critically, the reported platform advances microresonator spectrometer technology by permitting room-temperature, aqueous experimental conditions, which may be used for time-resolved single-particle experiments on non-emissive, nanoscale analytes engaged in catalytically and biologically relevant chemical dynamics. ...
Three-Dimensional Molecular Transfer from DNA Nanocages to Inner Gold Nanoparticle Surfaces
ACS Nano (IF 13.903) Pub Date : 2019-04-08 ,DOI:10.1021/acsnano.8b09147
It is of great interest to construct DNA-functionalized gold nanoparticles (DNA-AuNPs) with a controllable number of DNA strands and relative orientations. Herein, we describe a three-dimensional (3D) molecular transfer strategy, in which a pattern of DNA strands can be transferred from a DNA icosahedron cage (I-Cage) to the wrapped AuNP surface. The results show that DNA-AuNPs produced by this method inherit DNA pattern information encoded in the transient I-Cage template with high fidelity. Controllable numbers and positions of DNA on the surface of AuNPs can be simultaneously realized by direct “printing” of a DNA pattern from the nanoshell (I-Cage) to the nanocore (AuNP), further expanding the applications of DNA nanotechnology to nanolithography. Prospectively, the customized DNA-printed nanoparticles possess great potential for constructing programmable architectures for optoelectronic devices as well as smart biosensors for biomedical applications. ...
Resolving Single-Nanoconstruct Dynamics during Targeting and Nontargeting Live-Cell Membrane Interactions
ACS Nano (IF 13.903) Pub Date : 2019-08-09 ,DOI:10.1021/acsnano.9b03144
This paper describes how differences in the dynamics of targeting and nontargeting constructs can provide information on nanoparticle (NP)–cell interactions. ...
Covalent-Cross-Linked Plasmene Nanosheets
ACS Nano (IF 13.903) Pub Date : 2019-06-07 ,DOI:10.1021/acsnano.9b01343
Thiol-polystyrene (SH-PS)-capped plasmonic nanoparticles can be fabricated into free-standing, one-nanoparticle-thick superlattice sheets (termed plasmene) based on physical entanglement between ligands, which, however, suffer from irreversible dissociation in organic solvents. ...
Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery
ACS Nano (IF 13.903) Pub Date : 2019-04-02 ,DOI:10.1021/acsnano.8b07858
In addition, we cover aspects of nanoparticle engineering and optimization for DNA therapeutics. Finally, we highlight achievements of lipid-based DNA therapies in clinical trials. ...
Hierarchical Porous Wood Cellulose Scaffold with Atomically Dispersed Pt Catalysts for Low-Temperature Ethylene Decomposition
ACS Nano (IF 13.903) Pub Date : 2019-12-05 ,DOI:10.1021/acsnano.9b07801
An objective of this work is to develop a fabrication technology that allows for the simultaneous control of the nanoparticle surface chemistry, elemental distribution, microscale geometry, and large-scale assembly. ...
Stacking as a Key Property for Creating Nanoparticles with Tunable Shape: The Case of Squalenoyl-Doxorubicin
ACS Nano (IF 13.903) Pub Date : 2019-10-15 ,DOI:10.1021/acsnano.9b05303
As those parameters are involved in nanoparticle behavior in biological media, these findings could bring interesting opportunities for drug delivery and serve as an example for the design of original nanodrugs with stacking properties tuned for particular clinical purposes. ...
Aluminum Nanocubes Have Sharp Corners
ACS Nano (IF 13.903) Pub Date : 2019-08-14 ,DOI:10.1021/acsnano.9b05277
Of the many plasmonic nanoparticle geometries that have been synthesized, nanocubes have been of particular interest for creating nanocavities, facilitating plasmon coupling, and enhancing phenomena dependent upon local electromagnetic fields. ...
Power Generation by Selective Self-Assembly of Biocatalysts
ACS Nano (IF 13.903) Pub Date : 2019-07-22 ,DOI:10.1021/acsnano.9b03013
Through a careful chemical and bioelectronic design we have created a system that uses self-assembly of enzyme–nanoparticle hybrids to yield bioelectrocatalytic functionality and to enable the harnessing of electrical power from biomass. ...
Halide Ligands To Release Strain in Cadmium Chalcogenide Nanoplatelets and Achieve High Brightness
ACS Nano (IF 13.903) Pub Date : 2019-04-17 ,DOI:10.1021/acsnano.8b09794
Zinc blende II–VI semiconductor nanoplatelets (NPLs) are defined at the atomic scale along the thickness of the nanoparticle and are initially capped with carboxylates on the top and bottom [001] facets. These ligands are exchanged on CdSe NPLs with halides that act as X-L-type ligands. ...
Monovalent and Oriented Labeling of Gold Nanoprobes for the High-Resolution Tracking of a Single-Membrane Molecule
ACS Nano (IF 13.903) Pub Date : 2019-07-01 ,DOI:10.1021/acsnano.9b01176
However, there are concerns about using a nanoparticle to label a single molecule because of its relatively large size and the possibility of cross-linking multiple target molecules, both of which could affect the original molecular dynamics. ...
Self-Assembled Chiral Nanoparticle Superstructures and Identification of Their Collective Optical Activity from Ligand Asymmetry
ACS Nano (IF 13.903) Pub Date : 2019-03-12 ,DOI:10.1021/acsnano.8b06269
The spontaneous self-assembly of chiral nanoparticles (NPs) into stationary fabrication has garnered great interest in technique investigation and science advancement due to its expected apparent properties via orderly collective behaviors. However, this kind of characterization of assembled nanoparticles superstructure (NPS) is rarely reported and is distinguished with monodispersed chiral NPs. In this work, we used l-cysteine (Cys) as the chiral molecule in the form of functional surfactant, which had capped CdS/CdTe NPs and was treated as a linkage bridge for constructing orderly assembled NPS. Among the circular dichrosim (CD) phenomenon, Cys ligands exhibit related changes in CD absorption, while whole-molecule solution was used for treatment in different pH-controlling procedures. Synthesized chiral NPs are organized into ordered rod-shaped NPS during the spontaneous self-assembly process, and the CD response of NPS is monitored in different cultivating times; it showed a persuasive response appears in sum frequency generation (SFG) spectroscopy. Both experimental works and theory calculation convey that the ordered stacking of chiral stabilizer and the chirality of NPS, which are identified from chiral molecular status and their collective optical activity, originated from ligand asymmetry. ...
A Magneto-Optical Nanoplatform for Multimodality Imaging of Tumors in Mice
ACS Nano (IF 13.903) Pub Date : 2019-06-20 ,DOI:10.1021/acsnano.9b01436
Moreover, the nanoparticle possessed a long-term blood circulation time (half-life at 49 h) and high tumor uptake (18% ID/g). ...
Charge-Transfer-Modulated Transparent Supercapacitor Using Multidentate Molecular Linker and Conductive Transparent Nanoparticle Assembly
ACS Nano (IF 13.903) Pub Date : 2019-10-23 ,DOI:10.1021/acsnano.9b04594
One of the most critical issues in preparing high-performance transparent supercapacitors (TSCs) is to overcome the trade-off between areal capacitance and optical transmittance as well as that between areal capacitance and rate capability. Herein, we introduce a TSC with high areal capacitance, fast rate capability, and good optical transparency by minimizing the charge transfer resistance between pseudocapacitive nanoparticles (NPs) using molecular linker- and conductive NP-mediated layer-by-layer (LbL) assembly. For this study, bulky ligand-stabilized manganese oxide (MnO) and indium tin oxide (ITO) NP multilayers are LbL-assembled through a ligand exchange reaction between native ligands and small multidentate linkers (tricarballylic acid). The introduced molecular linker substantially decreases the separation distance between neighboring NPs, thereby reducing the contact resistance of electrodes. Moreover, the periodic insertion of ITO NPs into the MnO NP-based electrodes can lower the charge transfer resistance without a meaningful loss of transmittance, which can significantly improve the areal capacitance. The areal capacitances of the ITO NP-free electrode and the ITO NP-incorporated electrode are 24.6 mF cm–2 (at 61.6% transmittance) and 40.5 mF cm–2 (at 60.8%), respectively, which outperforms state of the art TSCs. Furthermore, we demonstrate a flexible symmetric solid-state TSC that exhibits scalable areal capacitance and optical transmittance. ...
In Situ Observation of Nanoparticle Exsolution from Perovskite Oxides: From Atomic Scale Mechanistic Insight to Nanostructure Tailoring
ACS Nano (IF 13.903) Pub Date : 2019-10-24 ,DOI:10.1021/acsnano.9b05652
Understanding and controlling the formation of nanoparticles at the surface of functional oxide supports is critical for tuning activity and stability for catalytic and energy conversion applications. Here, we use a latest generation environmental transmission electron microscope to follow the exsolution of individual nanoparticles at the surface of perovskite oxides, with ultrahigh spatial and temporal resolution. Qualitative and quantitative analysis of the data reveals the atomic scale processes that underpin the formation of the socketed, strain-inducing interface that confers exsolved particles their exceptional stability and reactivity. This insight also enabled us to discover that the shape of exsolved particles can be controlled by changing the atmosphere in which exsolution is carried out, and additionally, this could also produce intriguing heterostructures consisting of metal–metal oxide coupled nanoparticles. Our results not only provide insight into the in situ formation of nanoparticles but also demonstrate the tailoring of nanostructures and nanointerfaces. ...
Dendritic Cell-Activating Magnetic Nanoparticles Enable Early Prediction of Antitumor Response with Magnetic Resonance Imaging
ACS Nano (IF 13.903) Pub Date : 2019-12-02 ,DOI:10.1021/acsnano.9b05037
These studies therefore provide a simple, scalable nanoparticle formulation to generate robust antitumor immune responses and predict individual treatment outcome with MRI. ...
Compact and Filter-Free Luminescence Biosensor for Mobile in Vitro Diagnoses
ACS Nano (IF 13.903) Pub Date : 2019-09-06 ,DOI:10.1021/acsnano.9b05634
Nanoparticle luminescence lifetime was extended by controlling particle structure and composition. ...
Tailor-Made Semiconducting Polymers for Second Near-Infrared Photothermal Therapy of Orthotopic Liver Cancer
ACS Nano (IF 13.903) Pub Date : 2019-06-14 ,DOI:10.1021/acsnano.9b03910
The prepared nanoparticle (NP) from the semiconducting polymer is used for treatment of orthotopic liver cancer upon laser irradiation. Compared with an 808 nm laser, a 1064 nm laser leads to more effective inhibition toward orthotopic liver cancer in the same conditions. ...
Multiscale Self-Assembly of Mobile-Ligand Molecular Nanoparticles for Hierarchical Nanocomposites
ACS Nano (IF 13.903) Pub Date : 2019-06-05 ,DOI:10.1021/acsnano.9b02569
Here, we demonstrate a class of mobile-ligand nanoparticle system built upon 1 nm anionic polyoxometalate molecular nanoparticles and cationic terminated polymer chains by electrostatic interaction. ...
Reversible Self-Assembly of Nanoprobes in Live Cells for Dynamic Intracellular pH Imaging
ACS Nano (IF 13.903) Pub Date : 2019-02-11 ,DOI:10.1021/acsnano.8b07054
Herein, we describe a robust reversible self-assembly system that is composed of a hydrophobic gold nanoparticle (AuNP) core and a shell of pH-responsive dye-incorporated block copolymers. ...
Effect of Nanogap Morphology on Plasmon Coupling
ACS Nano (IF 13.903) Pub Date : 2019-10-08 ,DOI:10.1021/acsnano.9b06492
Plasmon coupling is the fundamental principle by which the optical resonances in nanoparticleassemblies are tuned. Interactions of plasmons among nanoparticles in close proximity create plasmon coupling modes whose energies are sensitive to the nanogap parameters. ...
Using Polar Alcohols for the Direct Synthesis of Cesium Lead Halide Perovskite Nanorods with Anisotropic Emission
ACS Nano (IF 13.903) Pub Date : 2019-07-11 ,DOI:10.1021/acsnano.9b03508
Remarkably, the synthesis of the NRs has been achieved in polar alcohols, a class of solvents not usually found to be beneficial in classical perovskite nanoparticle synthesis. ...
A Mn(III)-Sealed Metal–Organic Framework Nanosystem for Redox-Unlocked Tumor Theranostics
ACS Nano (IF 13.903) Pub Date : 2019-05-30 ,DOI:10.1021/acsnano.9b00300
Mn(III), as a sealer, not only quenched TCPP-based fluorescence but also inhibited reactive oxygen species (ROS) generation, which made MOFs an “inert” theranostic nanoparticle. ...
Triple-Labeling of Polymer-Coated Quantum Dots and Adsorbed Proteins for Tracing their Fate in Cell Cultures
ACS Nano (IF 13.903) Pub Date : 2019-03-26 ,DOI:10.1021/acsnano.9b00728
As the quantum dots are intrinsically fluorescent, and as the polymer coating and the HSA were fluorescent labeled, the final nanoparticle had three differently fluorescent components: the quantum dot core, the polymer shell, and the human serum albumin corona. ...
Correction to Charge-Transfer-Modulated Transparent Supercapacitor Using Multidentate Molecular Linker and Conductive Transparent Nanoparticle Assembly
ACS Nano (IF 13.903) Pub Date : 2019-12-20 ,DOI:10.1021/acsnano.9b09390
In the published article, the name of coauthor Yongkwon Song is incorrectly listed as Youngkwon Song. Therefore, we would like to modify the author name as Yongkwon Song. On page 12719, the author list should read as Jimin Choi†, Donghyeon Nam†, Dongyeeb Shin†, Yongkwon Song†, Cheong Hoon Kwon†, Ikjun Cho†, Seung Woo Lee,*,‡ and Jinhan Cho*,‡ The change to the author name does not affect the reported trajectories and conclusions of the paper. The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsnano.9b09390. (PDF) (PDF) Electronic Supporting Information files are available without a subscription to ACS Web Editions. The American Chemical Society holds a copyright ownership interest in any copyrightable Supporting Information. Files available from the ACS website may be downloaded for personal use only. Users are not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information from the ACS website, either in whole or in part, in either machine-readable form or any other form without permission from the American Chemical Society. For permission to reproduce, republish and redistribute this material, requesters must process their own requests via the RightsLink permission system. Information about how to use the RightsLink permission system can be found at http://pubs.acs.org/page/copyright/permissions.html. This article has not yet been cited by other publications. The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsnano.9b09390. (PDF) (PDF) Electronic Supporting Information files are available without a subscription to ACS Web Editions. The American Chemical Society holds a copyright ownership interest in any copyrightable Supporting Information. Files available from the ACS website may be downloaded for personal use only. Users are not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information from the ACS website, either in whole or in part, in either machine-readable form or any other form without permission from the American Chemical Society. For permission to reproduce, republish and redistribute this material, requesters must process their own requests via the RightsLink permission system. Information about how to use the RightsLink permission system can be found at http://pubs.acs.org/page/copyright/permissions.html. ...
Kinetics and Mechanism of Metal Nanoparticle Growth via Optical Extinction Spectroscopy and Computational Modeling: The Curious Case of Colloidal Gold
ACS Nano (IF 13.903) Pub Date : 2019-09-09 ,DOI:10.1021/acsnano.9b04981
An overarching computational framework unifying several optical theories to describe the temporal evolution of gold nanoparticles (GNPs) during a seeded growth process is presented. To achieve this, we used the inexpensive and widely available optical extinction spectroscopy, to obtain quantitative kinetic data. In situ spectra collected over a wide set of experimental conditions were regressed using the physical model, calculating light extinction by ensembles of GNPs during the growth process. This model provides temporal information on the size, shape, and concentration of the particles and any electromagnetic interactions between them. Consequently, we were able to describe the mechanism of GNP growth and divide the process into distinct genesis periods. We provide explanations for several longstanding mysteries, for example, the phenomena responsible for the purple-greyish hue during the early stages of GNP growth, the complex interactions between nucleation, growth, and aggregation events, and a clear distinction between agglomeration and electromagnetic interactions. The presented theoretical formalism has been developed in a generic fashion so that it can readily be adapted to other nanoparticulate formation scenarios such as the genesis of various metal nanoparticles. ...
Quantitative 3D Characterization of Elemental Diffusion Dynamics in Individual Ag@Au Nanoparticles with Different Shapes
ACS Nano (IF 13.903) Pub Date : 2019-10-25 ,DOI:10.1021/acsnano.9b06848
In this work, we apply the proposed method to compare the alloying dynamics of Au–Ag nanoparticles with different shapes and compositions and find that the shape of the nanoparticle does not exhibit a significant effect on the alloying speed whereas the composition does. ...
Age-Dependent Translocation of Gold Nanoparticles across the Air–Blood Barrier
ACS Nano (IF 13.903) Pub Date : 2019-08-16 ,DOI:10.1021/acsnano.9b03019
Findings from this study are critical to design optimal ways of inhalation drug delivery using NP nanocarriers for this age group, as well as for better understanding of the potential adverse health effects of nanoparticle exposures in infants and young children. ...
Self-Organized, One-Dimensional Periodic Structures in a Gold Nanoparticle-Doped Nematic Liquid Crystal Composite
ACS Nano (IF 13.903) Pub Date : 2019-08-22 ,DOI:10.1021/acsnano.9b03302
Composite structures exhibiting a periodic arrangement of building blocks can be found in natural systems at different length scales. Recreating such systems in artificial composites using the principles of self-assembly has been a great challenge, especially for 1D microscale systems. Here, we present a purposely designed composite material consisting of gold nanoparticles and a nematic liquid crystal matrix that has the ability to self-create a periodic structure in the form of a one-dimensional photonic lattice through a phase separation process occurring in a confined space. Our strategy is based on the use of a thermoswitchable medium that reversibly and quickly responds to both heating and cooling. We find that the period of the structure is strongly related to the size of the confining space. We believe that our findings will allow us to not only better understand the phase separation process in multicomponent soft/colloid mixtures with useful optical properties but also improve our understanding of the precise assembly of advanced materials into one-dimensional periodic systems, with prospective applications in future photonic technologies. ...
Three-Dimensional Quantitative Co-Mapping of Pulmonary Morphology and Nanoparticle Distribution with Cellular Resolution in Nondissected Murine Lungs
ACS Nano (IF 13.903) Pub Date : 2019-01-14 ,DOI:10.1021/acsnano.8b07524
Deciphering biodistribution, biokinetics, and biological effects of nanoparticles (NPs) in entire organs with cellular resolution remains largely elusive due to the lack of effective imaging tools. Here, light sheet fluorescence microscopy in combination with optical tissue clearing was validated for concomitant three-dimensional mapping of lung morphology and NP biodistribution with cellular resolution in nondissected ex vivo murine lungs. Tissue autofluorescence allowed for label-free, quantitative morphometry of the entire bronchial tree, acinar structure, and blood vessels. Co-registration of fluorescent NPs with lung morphology revealed significant differences in pulmonary NP distribution depending on the means of application (intratracheal instillation and ventilator-assisted aerosol inhalation under anesthetized conditions). Inhalation exhibited a more homogeneous NP distribution in conducting airways and acini indicated by a central-to-peripheral (C/P) NP deposition ratio of unity (0.98 ± 0.13) as compared to a 2-fold enhanced central deposition (C/P = 1.98 ± 0.37) for instillation. After inhalation most NPs were observed in the proximal part of the acini as predicted by computational fluid dynamics simulations. At cellular resolution patchy NP deposition was visualized in bronchioles and acini, but more pronounced for instillation. Excellent linearity of the fluorescence intensity–dose response curve allowed for accurate NP dosimetry and revealed ca. 5% of the inhaled aerosol was deposited in the lungs. This single-modality imaging technique allows for quantitative co-registration of tissue architecture and NP biodistribution, which could accelerate elucidation of NP biokinetics and bioactivity within intact tissues, facilitating both nanotoxicology studies and the development of nanomedicines. ...
Programmable Ultralight Magnets via Orientational Arrangement of Ferromagnetic Nanoparticles within Aerogel Hosts
ACS Nano (IF 13.903) Pub Date : 2019-12-04 ,DOI:10.1021/acsnano.9b04818
However, owing to a higher density of conventional ferromagnets or nanoparticle-containing polymers and strong magnetic fields required for actuation, fabricating lightweight materials with a sensitive magnetic response for weight critical applications is challenging. ...
Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors
ACS Nano (IF 13.903) Pub Date : 2019-09-20 ,DOI:10.1021/acsnano.9b02395
Here, we demonstrate that a pretreatment based on a proteolytic-enzyme nanoparticle system disassembles the dense PDAC collagen stroma and increases drug penetration into the pancreatic tumor. ...
Tailoring Porphyrin Conjugation for Nanoassembly-Driven Phototheranostic Properties
ACS Nano (IF 13.903) Pub Date : 2019-04-01 ,DOI:10.1021/acsnano.9b00494
However, the effects of the conjugate structure on the associated nanoparticle’s phototherapeutic properties warrants further investigation. ...
Glucose-Responsive Nanoparticles for Rapid and Extended Self-Regulated Insulin Delivery
ACS Nano (IF 13.903) Pub Date : 2019-12-20 ,DOI:10.1021/acsnano.9b06395
We believe the nanoparticle formulations developed here may provide a generalized strategy for the development of glucose-responsive insulin delivery systems. ...
Engineering a Biodegradable Multifunctional Antibacterial Bioactive Nanosystem for Enhancing Tumor Photothermo-Chemotherapy and Bone Regeneration
ACS Nano (IF 13.903) Pub Date : 2019-12-24 ,DOI:10.1021/acsnano.9b06145
Herein, we designed a biodegradable monodispersed bioactive glass nanoparticle (BGN) platform with multifunctional properties for enhanced colon cancer photothermo-chemotherapy and bone repair. ...
Enzyme-Powered Gated Mesoporous Silica Nanomotors for On-Command Intracellular Payload Delivery
ACS Nano (IF 13.903) Pub Date : 2019-10-10 ,DOI:10.1021/acsnano.9b06706
Studies with HeLa cells indicate that the presence of biofuel urea enhances nanoparticle internalization and both [Ru(bpy)3]Cl2 or doxorubicin intracellular release due to the acidity of lysosomal compartments. ...
Janus to Core–Shell to Janus: Facile Cation Movement in Cu2–xS/Ag2S Hexagonal Nanoplates Induced by Surface Strain Control
ACS Nano (IF 13.903) Pub Date : 2019-10-04 ,DOI:10.1021/acsnano.9b05784
When the surface strain was relieved by a reduced Pt concentration at the nanoparticle surface, the core–shell transitioned back into a Janus structure. ...
Corona Composition Can Affect the Mechanisms Cells Use to Internalize Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2019-09-23 ,DOI:10.1021/acsnano.9b03824
Overall, the results confirmed that the corona composition can affect the mechanisms of nanoparticleuptake by cells. ...
Multiscale Buffering Engineering in Silicon–Carbon Anode for Ultrastable Li-Ion Storage
ACS Nano (IF 13.903) Pub Date : 2019-08-22 ,DOI:10.1021/acsnano.9b03355
The perfect multiscale elastic buffering makes this material more stable compared to common Si nanoparticle-assembled counterpart electrodes. ...
Plasmonic Ti3C2Tx MXene Enables Highly Efficient Photothermal Conversion for Healable and Transparent Wearable Device
ACS Nano (IF 13.903) Pub Date : 2019-06-20 ,DOI:10.1021/acsnano.9b03161
Herein, we demonstrate that the incorporation of ultrasmall quantities of plasmonic silver nanoparticle(AgNP)@MXene nanosheet hybrids to serve as photothermal fillers in waterborne elastic polyurethane enables high transparency as well as effective light-triggered healing capabilities for wearable composite ...
Non-Lamellar Lyotropic Liquid Crystalline Lipid Nanoparticles for the Next Generation of Nanomedicine
ACS Nano (IF 13.903) Pub Date : 2019-05-22 ,DOI:10.1021/acsnano.8b07961
Together with our perspectives and expert opinions, we anticipate that this review will guide future studies in developing LCNP-based drug delivery nanocarriers with the objective of translating them into a key player among nanoparticle platforms comprising the next generation of nanomedicine for disease ...
Solution Conditions Tune and Optimize Loading of Therapeutic Polyelectrolytes into Layer-by-Layer Functionalized Liposomes
ACS Nano (IF 13.903) Pub Date : 2019-04-18 ,DOI:10.1021/acsnano.9b00792
These results highlight the benefits of defining principles for constructing highly effective nanoparticlesystems. ...
Collective Cell Migration in 3D Epithelial Wound Healing
ACS Nano (IF 13.903) Pub Date : 2019-02-13 ,DOI:10.1021/acsnano.8b06305
The nanoparticle-mediated photothermal technique creates local hyperthermia for selective cell ablation and induces collective cell migration of 3D tissue structures. ...
Upconversion Nanoparticle-Assisted Payload Delivery from TiO2 under Near-Infrared Light Irradiation for Bacterial Inactivation
ACS Nano (IF 13.903) Pub Date : 2019-12-23 ,DOI:10.1021/acsnano.9b05386
The low penetration depth of UV light in mammalian tissue is the critical limitation for the use of TiO2-based photocatalysis in biomedical applications. In this work, we develop an effective near-infrared (NIR)-active photocatalytic platform that consists of a shell structure of upconversion nanocrystals decorated on a core of Au/dark-TiO2. The heart of this system is the strong photocatalytic activity in the visible region enabled by the gold surface-plasmon resonance on dark TiO2 (D-TiO2). Simulation and experiment demonstrate for an optimized Au/D-TiO2 combination a highly enhanced light absorption in the visible range. Using ampicillin sodium (AMP) as model drug, we exemplify the effective use of this principle by demonstrating a NIR light-triggered photocatalytic payload release. Importantly, the photocatalytically generated reactive oxygen species can effectively inactivate AMP-resistant bacteria strains, thus maintaining an antibacterial effect even after all drug is released. Overall, we anticipate that the here-introduced NIR-light-active photocatalytic cascade can considerably widen TiO2-based photocatalysis and its applications into the infrared range. ...
Polarized Single-Particle Quantum Dot Emitters through Programmable Cluster Assembly
ACS Nano (IF 13.903) Pub Date : 2019-12-31 ,DOI:10.1021/acsnano.9b06919
An octahedral DNA origami frame serves as a programmable scaffold for heterogeneous nanoparticleassembly into prescribed clusters. ...
Morphological and Structural Evolution of Co3O4 Nanoparticles Revealed by in Situ Electrochemical Transmission Electron Microscopy during Electrocatalytic Water Oxidation
ACS Nano (IF 13.903) Pub Date : 2019-10-11 ,DOI:10.1021/acsnano.9b04745
This in situ EC-TEM method enables us to observe the chemical, morphological, and structural evolutions occurring in the initial nanoparticle-based electrode exposed to different aqueous electrolytes and under OER conditions. ...
Sequentially Site-Specific Delivery of Thrombolytics and Neuroprotectant for Enhanced Treatment of Ischemic Stroke
ACS Nano (IF 13.903) Pub Date : 2019-07-24 ,DOI:10.1021/acsnano.9b01798
The tP-NP-rtPA/ZL006e consists of a ZL006e-loaded dextran derivative polymeric nanoparticle core and platelet membrane shell conjugated with thrombin-cleavable Tat-peptide-coupled rtPA. ...
Engineering Zero-Dimensional Quantum Confinement in Transition-Metal Dichalcogenide Heterostructures
ACS Nano (IF 13.903) Pub Date : 2019-06-26 ,DOI:10.1021/acsnano.9b03716
Traditional colloidal nanoparticle and epitaxially grown quantum dots are also impractical for solid-state devices, due to either complex surface chemistry, unreliable spatial positioning, or lack of electrical and optical access. ...
Preferential Binding of Cytochrome c to Anionic Ligand-Coated Gold Nanoparticles: A Complementary Computational and Experimental Approach
ACS Nano (IF 13.903) Pub Date : 2019-05-22 ,DOI:10.1021/acsnano.9b01622
We anticipate that the combined use of simulation and experimental methods to characterize biomolecule–nanoparticle interactions, as demonstrated here, will become increasingly necessary as the complexity of such target systems grows. ...
Polysaccharide Nanoparticles Can Efficiently Modulate the Immune Response against an HIV Peptide Antigen
ACS Nano (IF 13.903) Pub Date : 2019-04-23 ,DOI:10.1021/acsnano.8b07662
These findings show that both the nanoparticle composition and the conjugation of the HIV peptide antigen may play an important role in the generation of humoral and cellular responses. ...
Synergetic Enhancement of Thermoelectric Performance by Selective Charge Anderson Localization–Delocalization Transition in n-Type Bi-Doped PbTe/Ag2Te Nanocomposite
ACS Nano (IF 13.903) Pub Date : 2019-02-13 ,DOI:10.1021/acsnano.8b08579
The introduction of random potentials via Ag2Te nanoparticle distribution using extrinsic phase mixing was determined using scanning tunneling spectroscopy measurements. ...
Use of Polymeric Nanoparticle Platform Targeting the Liver To Induce Treg-Mediated Antigen-Specific Immune Tolerance in a Pulmonary Allergen Sensitization Model
ACS Nano (IF 13.903) Pub Date : 2019-04-12 ,DOI:10.1021/acsnano.9b01444
Nanoparticles (NPs) can be used to accomplish antigen-specific immune tolerance in allergic and autoimmune disease. The available options for custom-designing tolerogenic NPs include the use of nanocarriers that introduce antigens into natural tolerogenic environments, such as the liver, where antigen presentation promotes tolerance to self- or foreign antigens. Here, we demonstrate the engineering of a biodegradable polymeric poly(lactic-co-glycolic acid) (PLGA) nanocarrier for the selective delivery of the murine allergen, ovalbumin (OVA), to the liver. This was accomplished by developing a series of NPs in the 200–300 nm size range as well as decorating particle surfaces with ligands that target scavenger and mannose receptors on liver sinusoidal endothelial cells (LSECs). LSECs represent a major antigen-presenting cell type in the liver capable of generating regulatory T-cells (Tregs). In vitro exposure of LSECs to NPOVA induced abundant TGF-β, IL-4, and IL-10 production, which was further increased by surface ligands. Animal experiments showed that, in the chosen size range, NPOVA was almost exclusively delivered to the liver, where the colocalization of fluorescent-labeled particles with LSECs could be seen to increase by surface ligand decoration. Moreover, prophylactic treatment with NPOVA in OVA-sensitized and challenged animals (aerosolized inhalation) could be seen to significantly suppress anti-OVA IgE responses, airway eosinophilia, and TH2 cytokine production in the bronchoalveolar lavage fluid. The suppression of allergic airway inflammation was further enhanced by attachment of surface ligands, particularly for particles decorated with the ApoB peptide, which induced high levels of TGF-β production in the lung along with the appearance of Foxp3+ Tregs. The ApoB-peptide-coated NPs could also interfere in allergic airway inflammation when delivered postsensitization. The significance of these findings is that liver and LSEC targeting PLGA NPs could be used for therapy of allergic airway disease, in addition to the potential of using their tolerogenic effects for other disease applications. ...
Magnetic-Sensitive Nanoparticle Self-Assembled Superhydrophobic Biopolymer-Coated Slow-Release Fertilizer: Fabrication, Enhanced Performance, and Mechanism
ACS Nano (IF 13.903) Pub Date : 2019-03-07 ,DOI:10.1021/acsnano.8b09197
Although commercialized slow-release fertilizers coated with petrochemical polymers have revolutionarily promoted agricultural production, more research should be devoted to developing superhydrophobic biopolymer coatings with superb slow-release ability from sustainable and ecofriendly biomaterials. To inform the development of the superhydrophobic biopolymer-coated slow-release fertilizers (SBSF), the slow-release mechanism of SBSF needs to be clarified. Here, the SBSF with superior slow-release performance, water tolerance, and good feasibility for large-scale production was self-assembly fabricated using a simple, solvent-free process. The superhydrophobic surfaces of SBSF with uniformly dispersed Fe3O4 superhydrophobic magnetic-sensitive nanoparticles (SMNs) were self-assembly constructed with the spontaneous migration of Fe3O4 SMNs toward the outermost surface of the liquid coating materials (i.e., pig fat based polyol and polymethylene polyphenylene isocyanate in a mass ratio 1.2:1) in a magnetic field during the reaction-curing process. The results revealed that SBSF showed longer slow-release longevity (more than 100 days) than those of unmodified biopolymer-coated slow-release fertilizers and excellent durable properties under various external environment conditions. The governing slow-release mechanism of SBSF was clarified by directly observing the atmosphere cushion on the superhydrophobic biopolymer coating using the synchrotron radiation-based X-ray phase-contrast imaging technique. Liquid water only contacts the top of the bulges of the solid surface (10.9%), and air pockets are trapped underneath the liquid (89.1%). The atmosphere cushion allows the slow diffusion of water vapor into the internal urea core of SBSF, which can decrease the nutrient release and enhance the slow-release ability. This self-assembly synthesis of SBSF through the magnetic interaction provides a strategy to fabricate not only ecofriendly biobased slow-release fertilizers but also other superhydrophobic materials for various applications. ...
Electrochemically Assembled Cu2O Nanoparticles Using Crystallographically Anisotropic Functional Metal Ions and Highly Expeditious Resistive Switching via Nanoparticle Coarsening
ACS Nano (IF 13.903) Pub Date : 2019-05-16 ,DOI:10.1021/acsnano.9b02108
We have developed an artificially controllable strategy of an electrodeposition process adequate for resistive random-access memory (ReRAM) applications of binary Cu2O. Typically, the precise control of OH– ion concentration (the intermediate supplier of oxygen ions) at the electrode’s surface decides the overall reaction rate of the Cu2O. Here, the suggested Pb and Sb metal additives preferentially contribute to the consumption of OH– ions and the supply of OH– ions, respectively, during the Cu2O electrochemical reaction so that the final products are the (200) preferential quadrangular pyramids and the (111) preferential triangular pyramids. Interestingly, the coexistence of Sb/Pb precursors in the Cu electrolytes results in extraordinarily decreased reaction rate from the opposite action of OH– ion utilization as well as intense progressive growth behavior, and the resultant Cu2O films consist of crystallized small-size nanoparticles (NPs) in an amorphous-like matrix. In the case of ReRAM applications, while the polycrystalline film induces irregular device performance and the amorphous layer shows an easily irreparable electrical breakdown, our NP-assembled Cu2O films from Pb/Sb metal ions reveal the formation of a conduction bridge via phase change to a crystalline filament with no need for forming voltage and with superior electrical stability. It is attributed to the coalescence of crystal NPs into large grains during the set/reset cycle process for the heat dissipation of Joule heating. The Cu2O sample prepared with a 3 mM Sb + 3 mM Pb mixture solution exhibits forming-free ReRAM devices with high on/off resistance ratios of 1.2 × 104 and long-term electrical/thermal stability. ...
Influence of Softness on the Stability of Binary Colloidal Crystals
ACS Nano (IF 13.903) Pub Date : 2019-11-15 ,DOI:10.1021/acsnano.9b04274
Mixtures of two types of nanoparticles can self-assemble into a wide variety of binary colloidal crystals (also called binary nanoparticle superlattices), which are interesting for their structural diversity and potential applications. ...
Extravasating Neutrophils Open Vascular Barrier and Improve Liposomes Delivery to Tumors
ACS Nano (IF 13.903) Pub Date : 2019-10-18 ,DOI:10.1021/acsnano.9b03848
Microleakage, a local perivascular nanoparticle deposition, was found both in malignant and healthy tissues. This type of liposomes leakage does not provide access to tumor cells and is presumably responsible for drug deposition in normal tissues. ...
Organosilica-Based Hollow Mesoporous Bilirubin Nanoparticles for Antioxidation-Activated Self-Protection and Tumor-Specific Deoxygenation-Driven Synergistic Therapy
ACS Nano (IF 13.903) Pub Date : 2019-08-06 ,DOI:10.1021/acsnano.9b02477
Herein, a “nitrogen-protected silica template” method is proposed to design a nanoantioxidant called an organosilica-based hollow mesoporous bilirubin nanoparticle (HMBRN), which can act as an excellent nanocarrier to codeliver GOx and TPZ. ...
Photoablation of Human Vitreous Opacities by Light-Induced Vapor Nanobubbles
ACS Nano (IF 13.903) Pub Date : 2019-07-12 ,DOI:10.1021/acsnano.9b04050
Gold nanoparticle-assisted photoablation may therefore provide a safer, faster, and more reliable destruction of vitreous opacities in the treatment of ophthalmologic diseases. ...
Tunable Synthesis of Hollow Metal–Nitrogen–Carbon Capsules for Efficient Oxygen Reduction Catalysis in Proton Exchange Membrane Fuel Cells
ACS Nano (IF 13.903) Pub Date : 2019-06-24 ,DOI:10.1021/acsnano.9b02930
Atomically dispersed metal catalysts anchored on nitrogen-doped (N-doped) carbons demand attention due to their superior catalytic activity relative to that of metal nanoparticle catalysts in energy storage and conversion processes. ...
Precise Size Control of the Growth of Fe3O4 Nanocubes over a Wide Size Range Using a Rationally Designed One-Pot Synthesis
ACS Nano (IF 13.903) Pub Date : 2019-06-17 ,DOI:10.1021/acsnano.9b01281
Therefore, having an accurate control over the nanoparticle shape and size, while preserving the crystallinity, becomes crucial for many applications. ...
Biocompatible Nanoclusters with High Heating Efficiency for Systemically Delivered Magnetic Hyperthermia
ACS Nano (IF 13.903) Pub Date : 2019-05-17 ,DOI:10.1021/acsnano.8b06542
Despite its promising therapeutic potential, nanoparticle-mediated magnetic hyperthermia is currently limited to the treatment of localized and relatively accessible cancer tumors because the required therapeutic temperatures above 40 °C can only be achieved by direct intratumoral injection of conventional ...
Broadening the Message: A Nanovaccine Co-loaded with Messenger RNA and α-GalCer Induces Antitumor Immunity through Conventional and Natural Killer T Cells
ACS Nano (IF 13.903) Pub Date : 2019-02-15 ,DOI:10.1021/acsnano.8b07660
This study reports on a nanoparticle platform, named mRNA Galsomes, that successfully co-delivers nucleoside-modified antigen-encoding mRNA and the glycolipid antigen and immunopotentiator α-galactosylceramide (α-GC) to antigen-presenting cells after intravenous administration. ...
Self-Assembled “Off/On” Nanopomegranate for In Vivo Photoacoustic and Fluorescence Imaging: Strategic Arrangement of Kupffer Cells in Mouse Hepatic Lobules
ACS Nano (IF 13.903) Pub Date : 2019-02-13 ,DOI:10.1021/acsnano.8b07283
Herein, a fast self-assembled pomegranate structure-like nanoparticle with “nanopomegranate seeds” of dye aggregates has been developed, which has dual-modality “off/on” capability. ...
Controlled Nano–Bio Interface of Functional Nanoprobes for in Vivo Monitoring Enzyme Activity in Tumors
ACS Nano (IF 13.903) Pub Date : 2019-01-28 ,DOI:10.1021/acsnano.8b05825
The grafting/peeling-off strategy we developed for nanoparticle surface coating can fully control the targeting capability of functional nanoprobes by changing their colloidal behaviors such as diffusion and sedimentation rates at the desired sites. ...
Enhanced Generation of Non-Oxygen Dependent Free Radicals by Schottky-type Heterostructures of Au–Bi2S3 Nanoparticles via X-ray-Induced Catalytic Reaction for Radiosensitization
ACS Nano (IF 13.903) Pub Date : 2019-04-15 ,DOI:10.1021/acsnano.9b01818
As a consequence, this kind of nanoparticle provides an idea to develop rational designed Schottky-type heterostructures as efficient radiosensitizers for enhanced radiotherapy of cancer. ...
Synergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis Treatment
ACS Nano (IF 13.903) Pub Date : 2019-03-07 ,DOI:10.1021/acsnano.8b08785
Because hypoxia and ROS in the RA synovium play a crucial role in the induction of M1 macrophages and reduction of M2 macrophages, herein, we develop manganese ferrite and ceria nanoparticle-anchored mesoporous silica nanoparticles (MFC-MSNs) that can synergistically scavenge ROS and produce O2 for reducing ...
Ciliotherapy: Remote Control of Primary Cilia Movement and Function by Magnetic Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2019-03-15 ,DOI:10.1021/acsnano.9b00033
We devised the iron oxide nanoparticle (NP)-based technology for ciliotherapy. Live imaging confirmed that the CT-Fe2O3-NPs specifically targeted primary cilia in cultured cells in vitro and vascular endothelia in vivo. ...
Dual-Modal Imaging-Guided Precise Tracking of Bioorthogonally Labeled Mesenchymal Stem Cells in Mouse Brain Stroke
ACS Nano (IF 13.903) Pub Date : 2019-10-11 ,DOI:10.1021/acsnano.9b02173
This bioorthogonal labeling of hMSCs could greatly increase the cell labeling efficiency, safety, and imaging sensitivity, compared to only nanoparticle-derived labeling technology. ...
San Sebastian, a City of (Nano)Science and Technology
ACS Nano (IF 13.903) Pub Date : 2019-11-18 ,DOI:10.1021/acsnano.9b08789
Research areas include the use of scattering-type near-field optical microscopy for the study of nanoscale infrared spectroscopy of individual nanoparticles and films,(1,2) pioneering contributions in the field of nanoparticle synthesis(3−6) and assembly,(7−9) the study of plasmonic nanoantennas(10−12 ...
The origin of heterogeneous nanoparticle uptake by cells
Nature Communications (IF 11.878) Pub Date : 2019-05-28 ,DOI:10.1038/s41467-019-10112-4
Rather, it is the number of nanoparticle containing endosomes that are dependent on these initial dosing conditions. ...
Reciprocal Control of Hierarchical DNA Origami-Nanoparticle Assemblies
Nano Letters (IF 12.279) Pub Date : 2019-11-06 ,DOI:10.1021/acs.nanolett.9b02786
We selectively adjust the affinity of nanoparticle binding sites, resulting in hinge actuation via DNA melting without releasing the nanoparticle, thereby enabling rapid and reversible temperature-based actuation. ...
Stimuli-Responsive DNA-Linked Nanoparticle Arrays as Programmable Surfaces
Nano Letters (IF 12.279) Pub Date : 2019-06-11 ,DOI:10.1021/acs.nanolett.9b01340
In this work, the power of DNA-linked nanoparticle assembly is coupled to a grayscale patterning technique to create programmable surfaces for assembly and thermally activated reorganization of gold nanoparticle arrays. ...
Optical Processing of DNA-Programmed Nanoparticle Superlattices
Nano Letters (IF 12.279) Pub Date : 2019-10-16 ,DOI:10.1021/acs.nanolett.9b03258
The gradient in the heat profile, however, also induces thermophoretic motion within the nanoparticlefilm, resulting in microscale movement at a comparable time-scale. ...
An ultrahigh resolution pressure sensor based on percolative metal nanoparticle arrays
Nature Communications (IF 11.878) Pub Date : 2019-09-06 ,DOI:10.1038/s41467-019-12030-x
The outstanding behaviors of our devices make nanoparticle arrays for use as actuation materials for pressure measurement. ...
Measuring the Accessible Surface Area within the Nanoparticle Corona Using Molecular Probe Adsorption
Nano Letters (IF 12.279) Pub Date : 2019-11-04 ,DOI:10.1021/acs.nanolett.9b02647
However, this phase also controls molecular access to the nanoparticle surface, a property important for catalytic activity and sensor applications. ...
Binary Colloidal Nanoparticle Concentration Gradients in a Centrifugal Field at High Concentration
Nano Letters (IF 12.279) Pub Date : 2019-01-17 ,DOI:10.1021/acs.nanolett.8b04496
The variety of binary phase behaviors resulted from the two different nanoparticle concentration gradients, but to date, the gradients can only be empirically controlled. ...
Carboxylesterase-Cleavable Biotinylated Nanoparticle for Tumor-Dual Targeted Imaging
Theranostics (IF 8.063) Pub Date : 2019-09-25 ,DOI:10.7150/thno.37625
We anticipate that our fluorescence “Turn-On” nanoparticle could be applied for liver cancer diagnosis in clinic in the near future. Keywords: near-infrared, nanoparticle, carboxylesterase, biotin receptor, tumor imaging ...
Molecular identification of organic vapors driving atmospheric nanoparticle growth
Nature Communications (IF 11.878) Pub Date : 2019-09-30 ,DOI:10.1038/s41467-019-12473-2
Furthermore, the volatility distribution of these vapors is sufficient to explain nanoparticle growth without invoking particle-phase processes. ...
Glutathione-mediated biotransformation in the liver modulates nanoparticle transport
Nature Nanotechnology (IF 33.407) Pub Date : 2019-07-15 ,DOI:10.1038/s41565-019-0499-6
Glutathione-mediated biotransformation in the liver is a well-known detoxification process to eliminate small xenobiotics, but its impacts on nanoparticle retention, targeting and clearance are much less understood than liver macrophage uptake, even though both processes are involved in liver detoxification ...
Defect Dynamics at a Single Pt Nanoparticle during Catalytic Oxidation
Nano Letters (IF 12.279) Pub Date : 2019-07-05 ,DOI:10.1021/acs.nanolett.9b01332
Here, we report Bragg coherent X-ray diffraction imaging of defect dynamics in an individual Pt nanoparticle during catalytic methane oxidation. ...
Hierarchical Assembly of Plasmonic Nanoparticle Heterodimer Arrays with Tunable Sub-5 nm Nanogaps
Nano Letters (IF 12.279) Pub Date : 2019-06-18 ,DOI:10.1021/acs.nanolett.9b00792
It is the combination of these two features that is key to realizing nanoparticle assemblies’ potential, particular for device applications. ...
Nanoparticle-based hollow microstructures formed by two-stage nematic nucleation and phase separation
Nature Communications (IF 11.878) Pub Date : 2019-02-22 ,DOI:10.1038/s41467-019-08702-3
On further cooling, nematic domains nucleate inside the nanoparticle-rich isotropic domains, driving formation of hollow nanoparticle assemblies. Structural differentiation is controlled by nanoparticledensity and cooling rate. ...
Generalized On-Demand Production of Nanoparticle Monolayers on Arbitrary Solid Surfaces via Capillarity-Mediated Inverse Transfer
Nano Letters (IF 12.279) Pub Date : 2019-02-27 ,DOI:10.1021/acs.nanolett.9b00248
We believe that our method will provide unique opportunities to expand the utility of colloidal nanoparticles and to greatly improve the accessibility of nanoparticle-based sensing technologies. ...
In-situ aerosol nanoparticle characterization by small angle X-ray scattering at ultra-low volume fraction
Nature Communications (IF 11.878) Pub Date : 2019-03-08 ,DOI:10.1038/s41467-019-09066-4
We conclude that in-situ nanoparticle characterization with ultra-low volume fractions of ~10–10 is feasible with SAXS. Our technique opens up a doorway to the in-situ analysis of aerosol nanoparticles under atmospheric conditions. ...
Nanoparticle Delivery of Immunostimulatory Agents for Cancer Immunotherapy
Theranostics (IF 8.063) Pub Date : 2019-10-15 ,DOI:10.7150/thno.37216
Keywords: biomimetic nanoparticle, cancer immunotherapy, immune stimulation, adjuvant, cytokine, checkpoint blockade ...
Nanoparticle Size Influences Antigen Retention and Presentation in Lymph Node Follicles for Humoral Immunity
Nano Letters (IF 12.279) Pub Date : 2019-09-17 ,DOI:10.1021/acs.nanolett.9b02834
Here we discovered that antigen conjugated to nanoparticle carriers with different sizes impacts the intralymph node transport and specific cell interaction. ...
A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain
Nature Nanotechnology (IF 33.407) Pub Date : 2019-11-04 ,DOI:10.1038/s41565-019-0568-x
Nanoparticle-mediated drug delivery is especially useful for targets within endosomes because of the endosomal transport mechanisms of many nanomedicines within cells. ...
Gold Nanoparticle-Integrated Scaffolds for Tissue Engineering and Regenerative Medicine
Nano Letters (IF 12.279) Pub Date : 2019-03-20 ,DOI:10.1021/acs.nanolett.9b00472
We further describe using gold nanoparticle-integrated scaffolds to achieve improved stem cells proliferation and differentiation. Finally, we discuss the main challenges and prospects for clinical translation of gold nanoparticles-hybrid scaffolds. ...
A nanofluidic device for parallel single nanoparticle catalysis in solution
Nature Communications (IF 11.878) Pub Date : 2019-09-27 ,DOI:10.1038/s41467-019-12458-1
In response, we present a nanofluidic device for highly parallelized single nanoparticle catalysis in solution, based on fluorescence microscopy. ...
A Simple Glutathione-Responsive Turn-On Theranostic Nanoparticle for Dual-Modal Imaging and Chemo-Photothermal Combination Therapy
Nano Letters (IF 12.279) Pub Date : 2019-07-24 ,DOI:10.1021/acs.nanolett.9b02769
Here we report a novel and simple glutathione (GSH)-responsive turn-on theranostic nanoparticle for dual-modal imaging and combination therapy. ...
Nanoparticle Binding to Urokinase Receptor on Cancer Cell Surface Triggers Nanoparticle Disintegration and Cargo Release
Theranostics (IF 8.063) Pub Date : 2019-01-25 ,DOI:10.7150/thno.29445
Interestingly, in the presence of urokinase receptor, the uPAR-targeting nanoparticle disintegrates into 7.5 nm fragments and releases cargo, but not the non-targeting nanoparticles made from albumin by the same preparation method. ...

上一篇:2018年生物纳米研究经典报道(六)
下一篇:2019年生物纳米研究最新热点报道(二)
相关最新报道
疾病应用(检索)

Copyright©2020  Sunlipo Biotech Research Center for Nanomedicine(PubMed). All right reserved. 

 E-mail:sunlipotech@163.com(技术服务)info@med-nanotech.com(应用开发)

Tel:86-21-5127 9909    Fax:86-21-5193 6393

沪ICP备16052527号-1

沪公网安备 31011002001237号