纳米医学网
首页  |  关于我们  |   加入收藏  |  留言反馈
当前位置:首页 >
2019年生物纳米研究最新热点报道(二)
来源于:纳米医学网 | 作者: | 发布时间:2017-12-31 | 浏览:611



Patterning of Nanoparticle‐Based Aerogels and Xerogels by Inkjet Printing
Small (IF 10.856) Pub Date : 2019-08-08 ,DOI:10.1002/smll.201902186
Nanoparticle‐based voluminous 3D networks with low densities are a unique class of materials and are commonly known as aerogels. ...
Single‐Particle Tracking for Understanding Polydisperse Nanoparticle Dispersions
Small (IF 10.856) Pub Date : 2019-07-24 ,DOI:10.1002/smll.201901468
The analysis of particle tracks is conducted using a newly developed Bayesian algorithm that is called Maximum A posteriori Nanoparticle Tracking Analysis. ...
Sonoprinting of nanoparticle-loaded microbubbles: Unraveling the multi-timescale mechanism
Biomaterials (IF 10.273) Pub Date : 2019-06-27 ,DOI:10.1016/j.biomaterials.2019.119250
Several studies have shown the potential of nanoparticle-loaded microbubbles to effectively enhance the delivery of therapeutic agents to target tissue. ...
Nanoparticle-drug conjugates treating bacterial infections
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-19 ,DOI:10.1016/j.jconrel.2019.06.013
Since several limitations are exerted by the biological systems, there is an urge for the advancement of nanoparticle-drug conjugates for better proficiency. ...
Multifunctional hyaluronate – Nanoparticle hybrid systems for diagnostic, therapeutic and theranostic applications
Journal of Controlled Release (IF 7.901) Pub Date : 2019-04-05 ,DOI:10.1016/j.jconrel.2019.04.003
Furthermore, we show several exemplary applications of HA-nanoparticle hybrid systems and provide our perspectives to their futuristic translational applications. ...
Programmed degradation of a hierarchical nanoparticle with redox and light responsivity for self-activated photo-chemical enhanced chemodynamic therapy
Biomaterials (IF 10.273) Pub Date : 2019-09-13 ,DOI:10.1016/j.biomaterials.2019.119498
Remarkably, our hierarchical RLR nanoparticle is composed of an ultrasmall Fe3O4 nanoparticleengineered framework of hollow carbon matrix core and a nanoflower-like MnO2 shell. ...
Interplay between Short‐ and Long‐Ranged Forces Leading to the Formation of Ag Nanoparticle Superlattice
Small (IF 10.856) Pub Date : 2019-06-21 ,DOI:10.1002/smll.201901966
Nanoparticle (NP) superlattices have attracted increasing attention due to their unique physicochemical properties. ...
Formation of a Monolayer Protein Corona around Polystyrene Nanoparticles and Implications for Nanoparticle Agglomeration
Small (IF 10.856) Pub Date : 2019-04-25 ,DOI:10.1002/smll.201900974
Nanoparticle (NP) interactions with cells and organisms are mediated by a biomolecular adsorption layer, the so‐called “protein corona.” An in‐depth understanding of the corona is a prerequisite to successful and safe application of NPs in biology and medicine. ...
Spatiotemporally controllable diphtheria toxin expression using a light-switchable transgene system combining multifunctional nanoparticle delivery system for targeted melanoma therapy
Journal of Controlled Release (IF 7.901) Pub Date : 2019-12-12 ,DOI:10.1016/j.jconrel.2019.12.015
Significantly suppressed tumor angiogenesis was also identified in the nanoparticle-treated group likely due to the targeting ability of the RGD-modified nanoparticle. ...
A polyphenol-metal nanoparticle platform for tunable release of liraglutide to improve blood glycemic control and reduce cardiovascular complications in a mouse model of type II diabetes
Journal of Controlled Release (IF 7.901) Pub Date : 2019-12-12 ,DOI:10.1016/j.jconrel.2019.12.014
This ternary nanoparticle formulation offers sustained release of liraglutide for >8 days by optimizing the concentration of TA during nanoparticle assembly. ...
Inkjet Printing: Patterning of Nanoparticle‐Based Aerogels and Xerogels by Inkjet Printing (Small 39/2019)
Small (IF 10.856) Pub Date : 2019-09-25 ,DOI:10.1002/smll.201970212
Bigall and co‐workers manufacture semiconductor nanoparticle‐based aerogel‐coated electrodes automatically via inkjet printing. By simultaneously printing a destabilization agent and semiconductor nanoparticles, a 3D aerogel‐type network on a conducting and transparent surface is obtained. ...
Synergistic effect of all-trans-retinal and triptolide encapsulated in an inflammation-targeted nanoparticle on collagen-induced arthritis in mice
Journal of Controlled Release (IF 7.901) Pub Date : 2019-12-18 ,DOI:10.1016/j.jconrel.2019.12.025
Therefore, our results clearly show that GDR-TPT nanoparticle may represent a promising drug delivery system for the treatment of RA. ...
Focused Ultrasound Preconditioning for Augmented Nanoparticle Penetration and Efficacy in the Central Nervous System
Small (IF 10.856) Pub Date : 2019-10-22 ,DOI:10.1002/smll.201903460
Next, FUS preconditioning is applied prior to trans‐BBB nanoparticle delivery, yielding up to a fivefold increase in subsequent transgene expression. ...
Nanoparticle–Membrane Interactions: The Role of Temperature and Lipid Charge on Intake/Uptake of Cationic Gold Nanoparticles into Lipid Bilayers (Small 23/2019)
Small (IF 10.856) Pub Date : 2019-06-07 ,DOI:10.1002/smll.201970124
The combination of scattering studies and the computational approach provides a detailed molecular view of the mechanisms governing nanoparticle incorporation and membrane destabilization. ...
A pH-Activatable nanoparticle for dual-stage precisely mitochondria-targeted photodynamic anticancer therapy
Biomaterials (IF 10.273) Pub Date : 2019-05-18 ,DOI:10.1016/j.biomaterials.2019.05.030
This nanoparticle is composed of pH-responsive mPEG-b-PDPA-Cy7.5 fluorescent copolymer and mitochondria-targeted photosensitizer (TPPa). ...
Nanoparticle‐Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions
Small (IF 10.856) Pub Date : 2019-03-25 ,DOI:10.1002/smll.201900262
Subsequently, rapid‐moving advances of nanoparticle‐based cancer immunotherapies are summarized from traditional vaccine strategies to recent novel approaches, including delivery of immunotherapeutics (such as whole cancer cell vaccines, immune checkpoint blockade, and immunogenic cell death) and engineered ...
Protein Nanoparticles: A Novel Self‐Assembled Mitochondria‐Targeting Protein Nanoparticle Acting as Theranostic Platform for Cancer (Small 2/2019)
Small (IF 10.856) Pub Date : 2019-01-11 ,DOI:10.1002/smll.201970010
In article number 1803428, Jian Lin and co‐workers report the discovery of a novel self‐assembled metal protein nanoparticle, designated GST‐MT‐3, which targets the mitochondria of cancer cells within 30 min in vitro and rapidly accumulates in tumors within 1 h in vivo. ...
Development of hydrogel-like biomaterials via nanoparticle assembly and solid-hydrogel transformation
Journal of Controlled Release (IF 7.901) Pub Date : 2019-12-16 ,DOI:10.1016/j.jconrel.2019.12.026
The data show that GNPs with or without aptamer functionalization could form a nanoparticle-assembled porous solid biomaterial after freezing and lyophilization treatment. This formation did not need any additional crosslinking reactions. ...
Nanoparticle Linker‐Controlled Molecular Wire Devices Based on Double Molecular Monolayers
Small (IF 10.856) Pub Date : 2019-05-28 ,DOI:10.1002/smll.201901183
Here, new molecular wire junctions are reported to enhance charge transport through gold nanoparticle(AuNP)‐linked double self‐assembled monolayers (SAMs) of cobalt (II) bis‐terpyridine molecules (e.g., Co(II)(tpyphS)2). ...
Mixed Organic Ligand Shells: Controlling the Nanoparticle Surface Morphology toward Tuning the Optoelectronic Properties
Small (IF 10.856) Pub Date : 2019-11-28 ,DOI:10.1002/smll.201903729
Precise control over the ratio of perylene bisimide (PBI) monomers and aggregates, immobilized on alumina nanoparticle (NP) surfaces, is demonstrated. ...
Nanoparticle‐Embedded Electrospun Fiber–Covered Stent to Assist Intraluminal Photodynamic Treatment of Oesophageal Cancer
Small (IF 10.856) Pub Date : 2019-10-28 ,DOI:10.1002/smll.201904979
Taken together, this work shows that the fiber‐covered stent as a nanoparticle delivery platform can enable effective PDT as a noninvasive treatment method for patients with advanced‐stage oesophageal cancer. ...
Combinatorial Delivery of miRNA‐Nanoparticle Conjugates in Human Adipose Stem Cells for Amplified Osteogenesis
Small (IF 10.856) Pub Date : 2019-11-14 ,DOI:10.1002/smll.201902864
Herein, the independent temporal control of the co‐delivery of miR‐148b and miR‐21 mimic plasmonic nanoparticle conjugates to induce osteogenic differentiation of human adipose stem cells (hASCs), in a de novo fashion, is described. ...
Nanoparticle Conjugation of Ginsenoside Rg3 Inhibits Hepatocellular Carcinoma Development and Metastasis
Small (IF 10.856) Pub Date : 2019-12-09 ,DOI:10.1002/smll.201905233
In conclusion, nanoparticle conjugation of ginsenoside Rg3 inhibits HCC development and metastasis via the remodeling of unbalanced gut microbiota and metabolism in vivo, providing an antitumor therapy strategy. ...
Nanoparticle-mediated intratumoral inhibition of miR-21 for improved survival in glioblastoma
Biomaterials (IF 10.273) Pub Date : 2019-02-14 ,DOI:10.1016/j.biomaterials.2019.02.016
We show that both nanoparticle products facilitate efficient intracellular delivery and miR-21 suppression that leads to PTEN upregulation and apoptosis of human GBM cells. ...
In vivo cancer targeting via glycopolyester nanoparticle mediated metabolic cell labeling followed by click reaction
Biomaterials (IF 10.273) Pub Date : 2019-06-25 ,DOI:10.1016/j.biomaterials.2019.119305
We developed glycopolyesters (GPs) via azido-sugar initiated ring-opening polymerization of O-carboxyanhydrides (OCAs) and achieved efficient in vivo cancer targeting via GP-nanoparticle (GP-NP) mediated metabolic cell labeling followed by Click reaction. ...
An integrin-based nanoparticle that targets activated hepatic stellate cells and alleviates liver fibrosis
Journal of Controlled Release (IF 7.901) Pub Date : 2019-04-17 ,DOI:10.1016/j.jconrel.2019.04.022
This nanoparticle system showed great promise to deliver therapeutic agents to aHSC to treat liver fibrosis. ...
Hypoxia-responsive nanoparticle based drug delivery systems in cancer therapy: An up-to-date review
Journal of Controlled Release (IF 7.901) Pub Date : 2019-12-24 ,DOI:10.1016/j.jconrel.2019.12.041
Consequently, hypoxia triggered nanoparticle based drug delivery systems is a rapidly progressing research area in developing effective strategies to combat drug-resistance in solid tumors. ...
Photo-controlled liquid metal nanoparticle-enzyme for starvation/photothermal therapy of tumor by win-win cooperation
Biomaterials (IF 10.273) Pub Date : 2019-06-27 ,DOI:10.1016/j.biomaterials.2019.119303
Here, a highly cooperative liquid metal nanoparticle-enzyme ([email protected]) was constructed for combinational starvation/photothermal therapy of tumor. ...
A novel NIR-Controlled NO release of sodium nitroprusside-doped Prussian blue nanoparticle for synergistic tumor treatment
Biomaterials (IF 10.273) Pub Date : 2019-05-21 ,DOI:10.1016/j.biomaterials.2019.05.024
Considering that sodium nitroprusside (SNP) and potassium ferricyanide have similar chemical structures, a near infrared (NIR) laser-controlled NO release nanoplatform has been fabricated by allowing SNP to participate in mesoporous Prussian blue (m-PB) nanoparticle formation. ...
Nanoparticle-mediated internal radioisotope therapy to locally increase the tumor vasculature permeability for synergistically improved cancer therapies
Biomaterials (IF 10.273) Pub Date : 2019-01-21 ,DOI:10.1016/j.biomaterials.2019.01.033
Our work highlights the great promises of employing nanoparticle-mediated RIT to modulate tumor vasculature for further enhanced cancer therapy, and may have potential value for clinical translation. ...
AuCu Alloy Nanoparticle Embedded Cu Submicrocone Arrays for Selective Conversion of CO2 to Ethanol
Small (IF 10.856) Pub Date : 2019-07-24 ,DOI:10.1002/smll.201902229
Herein, AuCu alloy nanoparticle embedded Cu submicrocone arrays (AuCu/Cu‐SCA) are constructed as an active, selective, and robust electrocatalyst for the CO2RR. ...
Shedding Light on the Trehalose‐Enabled Mucopermeation of Nanoparticles with Label‐Free Raman Spectroscopy
Small (IF 10.856) Pub Date : 2019-07-03 ,DOI:10.1002/smll.201901679
These spectroscopy‐based density mapping tools uncover the mechanism of mucus–nanoparticleinteractions and establish the protective role of trehalose microenvironment in minimizing the nanoparticle aggregation. ...
Characterizing the protein corona of sub-10 nm nanoparticles
Journal of Controlled Release (IF 7.901) Pub Date : 2019-04-17 ,DOI:10.1016/j.jconrel.2019.04.023
We discovered that when the nanoparticle is a cargo on the protein, the binding of the protein to the receptor target is minimally affected in contrast to the nanoparticle serving as a carrier. ...
Optimizing design parameters of a peptide targeted liposomal nanoparticle in an in vivo multiple myeloma disease model after initial evaluation in vitro
Journal of Controlled Release (IF 7.901) Pub Date : 2019-08-29 ,DOI:10.1016/j.jconrel.2019.08.033
employing a multifaceted synthetic strategy to prepare peptide-targeted nanoparticles of high purity, reproducibility, and with precisely controlled quantity of functionalities, we systematically evaluated the individual roles that peptide-linker length, peptide hydrophilicity, peptide density, and nanoparticle ...
Enzyme responsiveness enhances the specificity and effectiveness of nanoparticles for the treatment of B16F10 melanoma
Journal of Controlled Release (IF 7.901) Pub Date : 2019-11-02 ,DOI:10.1016/j.jconrel.2019.10.052
The nanoparticle characterization experiment demonstrated that in vivo drug delivery could be completed. In subsequent cell and animal experiments, the experimental data demonstrated the efficient therapeutic effects of the nanoparticle. ...
In-vitro and in-vivo Characterization of a Multi-Stage Enzyme-Responsive Nanoparticle-in-Microgel Pulmonary Drug Delivery System
Journal of Controlled Release (IF 7.901) Pub Date : 2019-11-09 ,DOI:10.1016/j.jconrel.2019.09.012
Here we address these contradictory design requirements by using a nanoparticle-inside-microgel system (Nano-in-Microgel). ...
Modulation of tumor microenvironment using a TLR-7/8 agonist-loaded nanoparticle system that exerts low-temperature hyperthermia and immunotherapy for in situ cancer vaccination
Biomaterials (IF 10.273) Pub Date : 2019-11-15 ,DOI:10.1016/j.biomaterials.2019.119629
This work proposes an immunomodulator (R848)-loaded nanoparticle system (R848@NPs) that can absorb near-infrared light (+NIR) to cause low-temperature hyperthermia that interacts synergistically with its loaded R848 to relieve the tumor-mediated immunosuppressive microenvironment, generating robust anti-tumor ...
In vivo activation of PEGylated long circulating lipid nanoparticle to achieve efficient siRNA delivery and target gene knock down in solid tumors
Journal of Controlled Release (IF 7.901) Pub Date : 2019-09-07 ,DOI:10.1016/j.jconrel.2019.09.004
We developed a lipid nanoparticle formulation (LNPK15) to deliver siRNA to a tumor for target gene knock down. ...
Standardization of research methods employed in assessing the interaction metallic-based nanoparticles and the blood-brain barrier: Present and future perspectives
Journal of Controlled Release (IF 7.901) Pub Date : 2019-01-18 ,DOI:10.1016/j.jconrel.2019.01.022
Thorough characterization could lead to improved interpretation of in vivo responses which could clarify nanoparticle properties that result in favorable in vivo outcomes whilst exposing nanoparticle-specific weaknesses. ...
Neurochemistry: Rapid Growth Cone Uptake and Dynein‐Mediated Axonal Retrograde Transport of Negatively Charged Nanoparticles in Neurons Is Dependent on Size and Cell Type (Small 2/2019)
Small (IF 10.856) Pub Date : 2019-01-11 ,DOI:10.1002/smll.201970012
Lee and co‐workers present a novel microfluidics device which makes the study of nanoparticle uptake and transport in neuron cultures possible. The somatic chamber at the top of this fluorescence image shows somato‐dendritic nanoparticle (red) uptake in the primary cortical neurons. ...
Melanin-like nanoparticles decorated with an autophagy-inducing peptide for efficient targeted photothermal therapy
Biomaterials (IF 10.273) Pub Date : 2019-03-01 ,DOI:10.1016/j.biomaterials.2019.02.023
The multifunctional nanoparticle was composed of dual peptide RGD- and beclin 1-modified and PEGylated melanin-like polydopamine nanoparticles. Beclin 1-derived peptide modified on the nanoparticle up-regulated autophagy in cancer cells and further sensitized the photothermal ablation to tumors. ...
Translation of nanomedicines from lab to industrial scale synthesis: The case of squalene-adenosine nanoparticles
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-29 ,DOI:10.1016/j.jconrel.2019.06.040
These analogs were isolated, characterized by multiple stage mass spectrometry, and their influence on nanoparticle properties further evaluated. ...
Mesoporous carbon manganese nanocomposite for multiple imaging guided oxygen-elevated synergetic therapy
Journal of Controlled Release (IF 7.901) Pub Date : 2019-12-24 ,DOI:10.1016/j.jconrel.2019.12.042
The PEG and iRGD are further decorated on MC-MnO2 (iPMC-MnO2) to improve the biocompatibility, targeting and penetration of the nanoparticle. ...
Hypoxia alleviation-triggered enhanced photodynamic therapy in combination with IDO inhibitor for preferable cancer therapy
Biomaterials (IF 10.273) Pub Date : 2019-03-22 ,DOI:10.1016/j.biomaterials.2019.03.027
In particular, the tumor hypoxic microenvironment is obviously relieved and much more reactive oxygen species (ROS) is generated by fluorinated nanoparticle compared with alkylated polymer nanoparticle as a control in vitro and in vivo, this is mainly because the fluorinated polymers are endowed with ...
Nanoparticle–Plant Interactions: Two‐Way Traffic
Small (IF 10.856) Pub Date : 2019-07-18 ,DOI:10.1002/smll.201901794
In this Review, an effort is made to discuss the most recent progress and future trend in the two‐way traffic of the interactions between plants and nanoparticles (NPs). One way is the use of plants to synthesize NPs in an environmentally benign manner with a focus on the mechanism and optimization of the synthesis. Another way is the effects of synthetic NPs on plant fate with a focus on the transport mechanisms of NPs within plants as well as NP‐mediated seed germination and plant development. When NPs are in soil, they can be adsorbed at the root surface, followed by their uptake and inter/intracellular movement in the plant tissues. NPs may also be taken up by foliage under aerial deposition, largely through stomata, trichomes, and cuticles, but the exact mode of NP entry into plants is not well documented. The NP–plant interactions may lead to inhibitory or stimulatory effects on seed germination and plant development, depending on NP compositions, concentrations, and plant species. In numerous cases, radiation‐absorbing efficiency, CO2 assimilation capacity, and delay of chloroplast aging have been reported in the plant response to NP treatments, although the mechanisms involved in these processes remain to be studied. ...
Threatening cancer with nanoparticle aided combination oncotherapy
Journal of Controlled Release (IF 7.901) Pub Date : 2019-03-16 ,DOI:10.1016/j.jconrel.2019.03.015
Employing combination therapy has become obligatory in cancer cases exhibiting high tumor load, chemoresistant tumor population, and advanced disease stages. Realization of this fact has now led many of the combination oncotherapies to become an integral part of anticancer regimens. Combination oncotherapy may encompass a combination of anticancer agents belonging to a similar therapeutic category or that of different therapeutic categories (e.g. chemotherapy + gene therapy). Differences in the physicochemical properties, pharmacokinetics and biodistribution pattern of different payloads are the major constraints that are faced by combination chemotherapy. Concordant efforts in the field of nanotechnology and oncology have emerged with several approaches to solve the major issues encountered by combination therapy. Unique colloidal behaviors of various types of nanoparticles and differential targeting strategies have accorded an unprecedented ability to optimize combination oncotherapeutic delivery. Nanocarrier based delivery of the various types of payloads such as chemotherapeutic agents and other anticancer therapeutics such as small interfering ribonucleic acid (siRNA), chemosensitizers, radiosensitizers, and antiangiogenic agents have been addressed in the present review. Various nano-delivery systems like liposomes, polymeric nanoparticles, polymerosomes, dendrimers, micelles, lipid based nanoparticles, prodrug based nanocarriers, polymer-drug conjugates, polymer-lipid hybrid nanoparticles, carbon nanotubes, nanosponges, supramolecular nanocarriers and inorganic nanoparticles (gold nanoparticles, silver nanoparticles, magnetic nanoparticles and mesoporous silica based nanoparticles) that have been extensively explored for the formulation of multidrug delivery is an imperative part of discussion in the review. The present review features the outweighing benefits of combination therapy over mono-oncotherapy and discusses several existent nanoformulation strategies that facilitate a successful combination oncotherapy. Several obstacles that may impede in transforming nanotechnology-based combination oncotherapy from bench to bedside, and challenges associated therein have also been discussed in the present review. ...
Artificial anaerobic cell dormancy for tumor gaseous microenvironment regulation therapy
Biomaterials (IF 10.273) Pub Date : 2019-02-07 ,DOI:10.1016/j.biomaterials.2019.02.007
Based on this speculation, an acid-responsive, oxygen-scavenging and anaerobic-sensitizing nanoparticlewas designed to regulate the oxygen level of solid tumor by creating an artificial anaerobic environment in our study. ...
Silica cloaking of adenovirus enhances gene delivery while reducing immunogenicity
Journal of Controlled Release (IF 7.901) Pub Date : 2019-01-25 ,DOI:10.1016/j.jconrel.2019.01.034
To overcome these challenges, we sought to merge the robustness of viral gene expression and the versatility of nanoparticle technology. Here, we describe a method for cloaking adenovirus (Ad) in silica (SiAd) as a nanoparticle formulation that significantly enhances transduction. ...
DNA Nanotechnology: Progress toward Understanding the Interactions between DNA Nanostructures and the Cell (Small 26/2019)
Small (IF 10.856) Pub Date : 2019-06-26 ,DOI:10.1002/smll.201970137
In article number 1805416, Chung Hang Jonathan Choi and co‐workers review the recent progress toward the basic understanding of cell–nano interactions of tile‐based, origami‐based and nanoparticle‐templated DNA nanostructures, highlighting the structural parameters and biological mechanism of cellular ...
Superstructures: Directing Gold Nanoparticles into Free‐Standing Honeycomb‐Like Ordered Mesoporous Superstructures (Small 31/2019)
Small (IF 10.856) Pub Date : 2019-08-02 ,DOI:10.1002/smll.201970165
In article number 1901304, Zewei Quan and co‐workers report the fabrication of free‐standing 2D honeycomb‐like gold superstructures by a simple method, which combines liquid interface‐mediated nanoparticle assembly with metallic attachment. ...
Defective Porous Carbon Polyhedra Decorated with Copper Nanoparticles for Enhanced NIR‐Driven Photothermal Cancer Therapy
Small (IF 10.856) Pub Date : 2019-12-01 ,DOI:10.1002/smll.201905184
Results encourage the wider use of MOFs as low cost precursors for the synthesis of carbon‐supported metal nanoparticle composites for photothermal therapy. ...
Quantitative and high drug loading of self-assembled prodrug with defined molecular structures for effective cancer therapy
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-08 ,DOI:10.1016/j.jconrel.2019.06.010
Both in vitro and in vivo results show that these GSH-responsive prodrug nanoparticle exhibits significant inhibition of tumor cell growth, and is promising for efficient and safe chemotherapeutic delivery. ...
Combination of KRAS gene silencing and PI3K inhibition for ovarian cancer treatment
Journal of Controlled Release (IF 7.901) Pub Date : 2019-12-12 ,DOI:10.1016/j.jconrel.2019.12.019
For successful delivery of siKRAS, tGC/psi—nanoparticle formulation of polymerized siRNA and thiol-modified glycol chitosan nanoparticle—was used for KRAS specific inhibition in vitro and in vivo. ...
Engineering an orchestrated release avalanche from hydrogels using DNA-nanotechnology
Journal of Controlled Release (IF 7.901) Pub Date : 2019-04-20 ,DOI:10.1016/j.jconrel.2019.04.028
By using complementary DNA sequences, nanoparticle aggregates are created, embedded into distinct layers of a hydrogel and released by triggering aggregate dispersal. ...
Biomaterials: Recombinant Silk Fiber Properties Correlate to Prefibrillar Self‐Assembly (Small 12/2019)
Small (IF 10.856) Pub Date : 2019-03-22 ,DOI:10.1002/smll.201970065
Rainey, and co‐workers demonstrate that improved self‐assembled silk protein nanoparticlemonodispersity in the concentrated solubilized spinning dope state correlates with dramatically improved wet‐spun recombinant aciniform silk fiber mechanical behavior. ...
Optimizing Biodegradable Nanoparticle Size for Tissue-Specific Delivery
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-22 ,DOI:10.1016/j.jconrel.2019.09.020
Nanoparticles (NPs) are promising vehicles for drug delivery because of their potential to target specific tissues [1]. Although it is known that NP size plays a critical role in determining their biological activity, there are few quantitative studies of the role of NP size in determining biodistribution after systemic administration. Here, we engineered fluorescent, biodegradable poly(lactic-co-glycolic acid) (PLGA) NPs in a range of sizes (120 – 440 nm) utilizing a microfluidic platform and used these NPs to determine the effect of diameter on bulk tissue and cellular distribution after systemic administration. We demonstrate that small NPs (∼120 nm) exhibit enhanced uptake in bulk lung and bone marrow, while larger NPs are sequestered in the liver and spleen. We also show that small NPs (∼120 nm) access specific alveolar cell populations and hematopoietic stem and progenitor cells more readily than larger NPs. Our results suggest that size of PLGA NPs can be used to tune delivery to certain tissues and cell populations in vivo. ...
Hierarchically Nanostructured Hybrid Platform for Tumor Delineation and Image‐Guided Surgery via NIR‐II Fluorescence and PET Bimodal Imaging
Small (IF 10.856) Pub Date : 2019-09-24 ,DOI:10.1002/smll.201903382
Interestingly, the incorporation of CH‐4T into the nanoparticle leads to 4.27‐fold fluorescence enhancement, resulting in brighter NIR‐II imaging for phantoms in vitro and in situ. ...
Co-delivery of immunomodulators in biodegradable nanoparticles improves therapeutic efficacy of cancer vaccines
Biomaterials (IF 10.273) Pub Date : 2019-08-07 ,DOI:10.1016/j.biomaterials.2019.119417
Whereas nanoparticle delivery of poly (I:C) or R848 improved therapeutic efficacy, the combination with MIP3α remarkably potentiated the cancer vaccine antitumor effects. ...
Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo
Biomaterials (IF 10.273) Pub Date : 2019-04-12 ,DOI:10.1016/j.biomaterials.2019.04.020
Herein, we describe a synthetic, bioreducible, biodegradable polymer that can package and deliver hundreds of siRNA molecules into a single nanoparticle, facilitating combination therapy against multiple GBM-promoting targets. ...
Mitochondria-targeted TPP-MoS2 with dual enzyme activity provides efficient neuroprotection through M1/M2 microglial polarization in an Alzheimer's disease model
Biomaterials (IF 10.273) Pub Date : 2019-12-30 ,DOI:10.1016/j.biomaterials.2019.119752
Many studies have focused on eliminating Aβ by nanoparticle affinity; however, nanoparticles are taken up mainly by microglia rather than neurons, leading poor control of AD. ...
Iron oxide nanoparticles promote macrophage autophagy and inflammatory response through activation of toll-like Receptor-4 signaling
Biomaterials (IF 10.273) Pub Date : 2019-02-28 ,DOI:10.1016/j.biomaterials.2019.02.026
Nanoparticle-induced autophagy is crucial for its metabolism, cytotoxicity and therapy potency, but little is known about how the host immune system would respond to it. ...
Plasmon‐Driven Rapid In Situ Formation of Luminescence Single Crystal Nanoparticle
Small (IF 10.856) Pub Date : 2019-06-25 ,DOI:10.1002/smll.201901286
Single crystal nanomaterials are very important for the fundamental investigation and application of luminescence. However, a very critical growth condition or high temperature treatment is always required for their preparation. Here, an easy and rapid in situ achievement of a single crystal luminescent material is realized by taking advantage of plasmon‐induced thermal and catalysis effects. With the assistance of localized surface plasmon resonance of Au nanoparticles, polycrystalline NaYF4 transforms to single crystal Y2O3 in tens of milliseconds, resulting in remarkable improvement of luminescence emission. It is important to point out that the single crystal transformation is also achieved even at a very low temperature, which is impossible with conventional approaches. Such a convenient and efficient plasmon assisted scheme provides a new technology for the rapid achievement of single crystal materials and extends the application of surface plasmon to a much broader field. ...
Programmable Atom Equivalents: Atomic Crystallization as a Framework for Synthesizing Nanoparticle Superlattices
Small (IF 10.856) Pub Date : 2019-04-10 ,DOI:10.1002/smll.201805424
Decades of research efforts into atomic crystallization phenomenon have led to a comprehensive understanding of the pathways through which atoms form different crystal structures. With the onset of nanotechnology, methods that use colloidal nanoparticles (NPs) as nanoscale “artificial atoms” to generate hierarchically ordered materials are being developed as an alternative strategy for materials synthesis. However, the assembly mechanisms of NP‐based crystals are not always as well‐understood as their atomic counterparts. The creation of a tunable nanoscale synthon whose assembly can be explained using the context of extensively examined atomic crystallization will therefore provide significant advancement in nanomaterials synthesis. DNA‐grafted NPs have emerged as a strong candidate for such a “programmable atom equivalent” (PAE), because the predictable nature of DNA base‐pairing allows for complex yet easily controlled assembly. This Review highlights the characteristics of these PAEs that enable controlled assembly behaviors analogous to atomic phenomena, which allows for rational material design well beyond what can be achieved with other crystallization techniques. ...
MicroRNA delivery through nanoparticles
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-14 ,DOI:10.1016/j.jconrel.2019.10.007
On the other hand, nanoparticle carriers offer unprecedented opportunities for cell specific controlled delivery of miRNAs for therapeutic purposes. ...
Nanoparticle-mediated approaches for Alzheimer’s disease pathogenesis, diagnosis, and therapeutics
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-21 ,DOI:10.1016/j.jconrel.2019.10.034
Alzheimer’s disease (AD) is an irreversible and progressive neurodegenerative disorder manifested by memory loss and cognitive impairment. Deposition of the amyloid β plaques has been identified as the most common AD pathology; however, the excessive accumulation of phosphorylated or total tau proteins, reactive oxygen species, and higher acetylcholinesterase activity are also strongly associated with Alzheimer’s dementia. Several therapeutic approaches targeting these pathogenic mechanisms have failed in clinical or preclinical trials, partly due to the limited bioavailability, poor cell, and blood-brain barrier penetration, and low drug half-life of current regimens. The nanoparticles (NPs)-mediated drug delivery systems improve drug solubility and bioavailability, thus renders as superior alternatives. Moreover, NPs-mediated approaches facilitate multiple drug loading and targeted drug delivery, thereby increasing drug efficacy. However, certain NPs can cause acute toxicity damaging cellular and tissue architecture, therefore, NP material should be carefully selected. In this review, we summarize the recent NPs-mediated studies that exploit various pathologic mechanisms of AD by labeling, identifying, and treating the affected brain pathologies. The disadvantages of the select NP-based deliveries and the future aspects will also be discussed. ...
Fabrication of Flexible and Transparent Conductive Nanosheets by the UV‐Irradiation of Gold Nanoparticle Monolayers
Small (IF 10.856) Pub Date : 2019-08-29 ,DOI:10.1002/smll.201903365
Conductive films that are highly transparent and flexible are extremely attractive for emerging optoelectronic applications. Currently, indium‐doped tin oxide films are the most widely used transparent conductive films and much research effort is devoted to developing alternative transparent conductive materials to overcome their drawbacks. In this work, a novel and facile approach for fabricating transparent conductive Au nanosheets from Au nanoparticles (AuNPs) is proposed. Irradiating an AuNP monolayer at the air–water interface with UV light results in a nanosheet with ≈3.5 nm thickness and ≈80% transparency in the UV–visible region. Further, the so‐fabricated nanosheets are highly flexible and can maintain their electrical conductivity even when they are bent to a radius of curvature of 0.6 mm. Fourier‐transform infrared and X‐ray photoelectron spectroscopy characterizations reveal that the transformation of the monolayer of AuNPs into the nanosheet is induced by the photodecomposition and/or photodetachment of the dodecanethiol ligands capping the AuNPs. Further, the UV‐irradiation of a hybrid monolayer consisting of AuNPs and silica particles affords the patterning of Au nanosheets with periodic hole arrays. ...
Exocytosis - a putative road-block in nanoparticle and nanocomplex mediated gene delivery
Journal of Controlled Release (IF 7.901) Pub Date : 2019-04-10 ,DOI:10.1016/j.jconrel.2019.04.012
Gene and drug delivery mediated by nanostructures has seen tremendous growth over the last decade. However, the efficiency of these delivery approaches needs to be improved for better effects. Amongst various factors, cellular retention is expected to play a critical role. Nanoparticles and nanocomplexes internalized by the cells can be recycled back to the outside through the process of exocytosis. Although it sounds reasonable that the efficiency of these delivery systems should not only depend on their cellular uptake but also on the ability of cells to retain them, the process of cellular retention and exocytosis is relatively less studied in the literature. In the context of gene delivery, both inorganic nanoparticles and organic nanocomplexes are used, but there is limited information on how these nanoparticles and nanocomplexes are recycled and what could be the possible effect of such recycling on the efficiency of these delivery vectors. In this review we try to summarize the existing literature in this area, putative mechanisms involved in recycling of the nanoparticles, methods used to quantify exocytosis and factors affecting exocytosis. The possibility of enhancing cellular retention by blocking recycling pathways as well as the in vivo implications is also discussed here. ...
Nanoparticle‐Regulated Semiartificial Magnetotactic Bacteria with Tunable Magnetic Moment and Magnetic Sensitivity
Small (IF 10.856) Pub Date : 2019-03-07 ,DOI:10.1002/smll.201900427
Micro‐/nanomotors are widely used in micro‐/nanoprocessing, cargo transportation, and other microscale tasks because of their ability to move independently. Many biological hybrid motors based on bacteria have been developed. Magnetotactic bacteria (MTB) have been employed as motors in biological systems because of their good biocompatibility and magnetotactic motion in magnetic fields. However, the magnetotaxis of MTB is difficult to control due to the lack of effective methods. Herein, a strategy that enables control over the motion of MTB is presented. By depositing synthetic Fe3O4 magnetic nanoparticles on the surface of MTB, semiartificial magnetotactic bacteria (SAMTB) are produced. The overall magnetic properties of SAMTB, including saturation magnetization, residual magnetization, and blocking temperature, are regulated in a multivariate and multilevel fashion, thus regulating the magnetic sensitivity of SAMTB. This strategy provides a feasible method to manoeuvre MTB for applications in complex fluid environments, such as magnetic drug release systems and real‐time tracking systems. Furthermore, this concept and methodology provide a paradigm for controlling the mobility of micro‐/nanomotors based on natural small organisms. ...
Herceptin-conjugated paclitaxel loaded PCL-PEG worm-like nanocrystal micelles for the combinatorial treatment of HER2-positive breast cancer
Biomaterials (IF 10.273) Pub Date : 2019-08-10 ,DOI:10.1016/j.biomaterials.2019.119420
The conjugated Herceptin greatly enhanced the binding ability of the nanoparticle to the targeted SKBR-3 cells. This novel strategy provides a rational and simple antibody-conjugated-nanoparticle platform for the clinical application of combinatorial anticancer treatment. ...
Recent advance of erythrocyte-mimicking nanovehicles: from bench to bedside
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-20 ,DOI:10.1016/j.jconrel.2019.10.032
Erythrocyte-mimicking nanovehicles (EM-NVs) are developed by fusing nanoparticle cores with naturally derived erythrocyte membranes. Compared with conventional nanosystems, EM-NVs hold preferable characteristics of prolonged blood circulation time and immune evasion. ...
Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions
Journal of Controlled Release (IF 7.901) Pub Date : 2019-07-19 ,DOI:10.1016/j.jconrel.2019.07.026
Geometric shape can modulate nanoparticle binding to the cell, especially by counteracting part of the hydrodynamic forces of the bloodstream encountered by the classical spherical shape. ...
Anti-inflammatory actions of folate-functionalized bioactive ion-releasing nanoparticles imply drug-free nanotherapy of inflamed tissues
Biomaterials (IF 10.273) Pub Date : 2019-03-27 ,DOI:10.1016/j.biomaterials.2019.03.034
Here we introduce folate-functionalized bioactive glass nanoparticle BGN(F) that can target pro-inflammatory cells to endocytose and release ions. The folate-conjugation significantly enhanced the nanoparticle internalization to LPS-induced pro-inflammatory cells. ...
Immunological consequences of chemotherapy: Single drugs, combination therapies and nanoparticle-based treatments
Journal of Controlled Release (IF 7.901) Pub Date : 2019-04-17 ,DOI:10.1016/j.jconrel.2019.04.020
The tumor environment has been shown to employ several immunosuppressive mechanisms to evade cancer treatments. While immunotherapies actively reverse such mechanisms, and polarize the immune system against malignant cells, combination of immunotherapy with certain chemotherapeutics leads to increased efficacy compared to each treatment alone. At low doses, chemotherapy demonstrates several immunogenic effects that can favorably potentiate immunotherapies. However, the clinical benefits of such therapies are confounded by the treatment complexity and marginal improvements. The highly complex relationship between chemotherapeutic drug dosing and subsequent immunological consequences is often generalized, thus limiting their understanding and potential. Also, simultaneous monitoring of the immunological impact is crucial for superior synergies during the optimization of chemotherapeutic combinations or usage of novel delivery systems. In this review, we summarize the existing literature on the immunological outcomes of chemotherapies administered individually, in combination regimens, and in formulation that use novel delivery agents. Further, we discuss the relevance of key parameters including dosage, schedule, and tumor models, and describe their clinical implications, with an emphasis on approaches and evaluations that are crucial for developing effective immune-stimulating therapies. ...
Plasmonic gold nanoparticles: Optical manipulation, imaging, drug delivery and therapy
Journal of Controlled Release (IF 7.901) Pub Date : 2019-08-28 ,DOI:10.1016/j.jconrel.2019.08.032
Over the past two decades, the development of plasmonic nanoparticle (NPs), especially plasmonic gold (Au) NPs, is being pursued more seriously in the medical fields such as imaging, drug delivery, and theranostic systems. ...
Sustained release of exendin-4 from tannic acid/Fe (III) nanoparticles prolongs blood glycemic control in a mouse model of type II diabetes
Journal of Controlled Release (IF 7.901) Pub Date : 2019-03-17 ,DOI:10.1016/j.jconrel.2019.03.014
In this study, we developed a tannic acid/exendin-4/Fe3+ ternary nanoparticle system to provide sustained release of exendin-4 in vivo. ...
Multimodal Precision Imaging of Pulmonary Nanoparticle Delivery in Mice: Dynamics of Application, Spatial Distribution, and Dosimetry
Small (IF 10.856) Pub Date : 2019-10-22 ,DOI:10.1002/smll.201904112
Targeted delivery of nanomedicine/nanoparticles (NM/NPs) to the site of disease (e.g., the tumor or lung injury) is of vital importance for improved therapeutic efficacy. Multimodal imaging platforms provide powerful tools for monitoring delivery and tissue distribution of drugs and NM/NPs. This study introduces a preclinical imaging platform combining X‐ray (two modes) and fluorescence imaging (three modes) techniques for time‐resolved in vivo and spatially resolved ex vivo visualization of mouse lungs during pulmonary NP delivery. Liquid mixtures of iodine (contrast agent for X‐ray) and/or (nano)particles (X‐ray absorbing and/or fluorescent) are delivered to different regions of the lung via intratracheal instillation, nasal aspiration, and ventilator‐assisted aerosol inhalation. It is demonstrated that in vivo propagation‐based phase‐contrast X‐ray imaging elucidates the dynamic process of pulmonary NP delivery, while ex vivo fluorescence imaging (e.g., tissue‐cleared light sheet fluorescence microscopy) reveals the quantitative 3D drug/particle distribution throughout the entire lung with cellular resolution. The novel and complementary information from this imaging platform unveils the dynamics and mechanisms of pulmonary NM/NP delivery and deposition for each of the delivery routes, which provides guidance on optimizing pulmonary delivery techniques and novel‐designed NM for targeting and efficacy. ...
Immune-triggered cancer treatment by intestinal lymphatic delivery of docetaxel-loaded nanoparticle
Journal of Controlled Release (IF 7.901) Pub Date : 2019-08-25 ,DOI:10.1016/j.jconrel.2019.08.027
The maximally tolerated dose (MTD) approach in conventional chemotherapy accompanies adverse effects, primarily due to high drug concentrations in the blood after intravenous administration and non-specific damages to highly proliferating cells, including immune cells. This causes the immune system to dysfunction. To rather boost intrinsic tumor-fighting immune capacity, we demonstrate a new oral route treatment regimen of docetaxel (DTX) without apparent toxicity. The DTX-loaded cationic solid lipid nanoparticles (DSLN-CSG) were coated with an anionic polymer conjugated with glycocholic acid. The resulting nanoparticles (DSLN-CSG, ~120 nm in diameter) were actively absorbed in the distal ileum mediated by interactions with the apical sodium bile acid transporter. The plasma DTX profile was sustained up to 24 h after a single oral dose and did not impair the functions of the immune system. In mouse models, daily oral DSLN-CSG administration inhibited the growth of existing tumors and tumor formation by medication prior to cancer cell inoculation. The extent of effects depended on the cancer cell lines of melanoma, colorectal adenocarcinoma, and breast carcinoma. It was most effective for melanoma in growth inhibition and in preventing tumor formation in mice. During the medication, the cytotoxic T cell population increased while the populations of tumor-associated macrophage and regulatory T cell declined. The low dose daily oral treatment may help patients with intermittent maintenance therapy between MTD cycles and prevent tumor recurrence after completing remission for certain tumors. ...
A High‐Throughput Automated Confocal Microscopy Platform for Quantitative Phenotyping of Nanoparticle Uptake and Transport in Spheroids
Small (IF 10.856) Pub Date : 2019-07-23 ,DOI:10.1002/smll.201902033
There is a high demand for advanced, image‐based, automated high‐content screening (HCS) approaches to facilitate phenotypic screening in 3D cell culture models. A major challenge lies in retaining the resolution of fine cellular detail but at the same time imaging multicellular structures at a large scale. In this study, a confocal microscopy‐based HCS platform in optical multiwell plates that enables the quantitative morphological profiling of populations of nonuniform spheroids obtained from HT‐29 human colorectal cancer cells is described. This platform is then utilized to demonstrate a quantitative dissection of the penetration of synthetic nanoparticles (NP) in multicellular 3D spheroids at multiple levels of scale. A pilot RNA interference‐based screening validates this methodology and identifies a subset of RAB GTPases that regulate NP trafficking in these spheroids. This technology is suitable for high‐content phenotyping in 3D cell‐based screening, providing a framework for nanomedicine drug development as applied to translational oncology. ...
Key Role of Microtubule and Its Acetylation in a Zinc Oxide Nanoparticle–Mediated Lysosome–Autophagy System
Small (IF 10.856) Pub Date : 2019-05-07 ,DOI:10.1002/smll.201901073
Autophagy is a biological process that has attracted considerable attention as a target for novel therapeutics. Recently, nanomaterials (NMs) have been reported to modulate autophagy, which makes them potential agents for the treatment of autophagy‐related diseases. In this study, zinc oxide nanoparticles (ZNPs) are utilized to evaluate NM‐induced autophagy and debate the mechanisms involved. It is found that ZNPs undergo pH‐dependent ion shedding and that intracellular zinc ions (Zn2+) play a crucial role in autophagy. Autophagy is activated with ZNPs treatment, which is inhibited after Zn2+ sequestration via ethylenediamine tetra‐acetic acid. Lysosome‐based autophagic degradation is halted after ZNPs treatment for more than 3 h and is accompanied by blockage of lysophagy, which renews impaired lysosomes. Furthermore, the microtubule (MT) system participates in ZNP‐induced lysosome–autophagy system changes, especially in the fusion between autophagosomes and lysosomes. MT acetylation is helpful for protecting from ZNP‐induced MT disruption, and it promotes the autophagic degradation process. In conclusion, this study provides valuable information on NM‐induced lysosome–autophagy system changes, particularly with respect to the role of lysophagy and the MT system, which point to some attractive targets for the design of engineered nanoparticles. ...
Selenoxide elimination manipulate the oxidative stress to improve the antitumor efficacy
Biomaterials (IF 10.273) Pub Date : 2019-09-24 ,DOI:10.1016/j.biomaterials.2019.119514
The β-seleno diesters and porphyrin derivates containing nanoparticle could be responsive to the intracellular ROS and produce acrylates through the elimination reaction. ...
Formation of Branched Ruthenium Nanoparticles for Improved Electrocatalysis of Oxygen Evolution Reaction
Small (IF 10.856) Pub Date : 2019-03-26 ,DOI:10.1002/smll.201804577
Branched nanoparticles are one of the most promising nanoparticle catalysts as their branch sizes and surfaces can be tuned to enable both high activity and stability. ...
Tailoring the lipid composition of nanoparticles modulates their cellular uptake and affects the viability of triple negative breast cancer cells
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-22 ,DOI:10.1016/j.jconrel.2019.06.025
However, the efficiency of nanoparticle uptake, i.e. the percent of nanoparticles taken up by cells, decreased as the concentration of nanoparticles increased. ...
Impact of chemistry and nanoformulation parameters on cellular uptake and airway distribution of RNA oligonucleotides
Journal of Controlled Release (IF 7.901) Pub Date : 2019-11-22 ,DOI:10.1016/j.jconrel.2019.11.025
The results reported here show clear differences between gymnotic and nanoparticle mediated ON delivery in terms of cellular uptake and local tissue distribution. ...
Encapsulation of tissue plasminogen activator in pH-sensitive self-assembled antioxidant nanoparticles for ischemic stroke treatment – Synergistic effect of thrombolysis and antioxidant –
Biomaterials (IF 10.273) Pub Date : 2019-05-13 ,DOI:10.1016/j.biomaterials.2019.05.020
To suppress reactive oxygen species (ROS) in the ischemic penumbra area, the low-molecular-weight nitroxide antioxidant 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl was covalently conjugated with the nanoparticle matrix, thus suppressing oxidative damage in the brain after reperfusion. t-PA and nitroxide ...
Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55
Journal of Controlled Release (IF 7.901) Pub Date : 2019-04-08 ,DOI:10.1016/j.jconrel.2019.04.009
SCRs were added to lepirudin plasma or sera from different healthy subjects, to monitor nanoparticle-mediated complement activation as well as C3 opsonization. ...
Rilpivirine-associated aggregation-induced emission enables cell-based nanoparticle tracking
Biomaterials (IF 10.273) Pub Date : 2019-12-07 ,DOI:10.1016/j.biomaterials.2019.119669
Antiretroviral therapy (ART) has improved the quality and duration of life for people living with human immunodeficiency virus (HIV) infection. However, limitations in drug efficacy, emergence of viral mutations and the paucity of cell-tissue targeting remain. We posit that to maximize ART potency and therapeutic outcomes newer drug formulations that reach HIV cellular reservoirs need be created. In a step towards achieving this goal we harnessed the aggregation-induced emission (AIE) property of the non-nucleoside reverse transcriptase inhibitor rilpivirine (RPV) and used it as a platform for drug cell and subcellular tracking. RPV nanocrystals were created with endogenous AIE properties enabling the visualization of intracellular particles in cell and tissue-based assays. The intact drug crystals were easily detected in CD4+ T cells and macrophages, the natural viral target cells, by flow cytometry and ultraperformance liquid chromatography tandem mass spectrometry. We conclude that AIE can be harnessed to monitor cell biodistribution of selective antiretroviral drug nanocrystals. ...
Zwitterionic polymer ligands: An ideal surface coating to totally suppress protein-nanoparticle corona formation?
Biomaterials (IF 10.273) Pub Date : 2019-07-15 ,DOI:10.1016/j.biomaterials.2019.119357
In the last few years, zwitterionic polymers have been developed as antifouling surface coatings. However, their ability to completely suppress protein adsorption at the surface of nanoparticles in complex biological media remains undemonstrated. Here we investigate the formation of hard (irreversible) and soft (reversible) protein corona around model nanoparticles (NPs) coated with sulfobetaine (SB), phosphorylcholine (PC) and carboxybetaine (CB) polymer ligands in model albumin solutions and in whole serum. We show for the first time a complete absence of protein corona around SB-coated NPs, while PC- and CB-coated NPs undergo reversible adsorption or partial aggregation. These dramatic differences cannot be described by naïve hard/soft acid/base electrostatic interactions. Single NP tracking in the cytoplasm of live cells corroborate these in vitro observations. Finally, while modification of SB polymers with additional charged groups lead to consequent protein adsorption, addition of small neutral targeting moieties preserves antifouling and enable efficient intracellular targeting. ...
Boosting the photodynamic therapy efficiency by using stimuli-responsive and AIE-featured nanoparticles
Biomaterials (IF 10.273) Pub Date : 2019-12-30 ,DOI:10.1016/j.biomaterials.2019.119749
Those presented stimuli-responsive nano-micelles loading MeTTMN exhibit good biocompatibility, excellent stability, appropriate nanoparticle size, high loading efficiency, outstanding imaging quality and significantly promoted PDT performance, eventually making them remarkably impressive and significantly ...
Role of Surface RGD Patterns on Protein Nanocages in Tumor Targeting Revealed Using Precise Discrete Models
Small (IF 10.856) Pub Date : 2019-11-25 ,DOI:10.1002/smll.201904838
Here, the role of the ligand functionalization patterns (number and distribution) on nanoparticle surfaces in tumor targeting is investigated using a 9 nm sized miniferritin protein nanocage, Dps modified with Arg‐Gly‐Asp (RGD) ligands whose functionalization patterns are precisely controlled. ...
Hydrothermal Coating of Patterned Carbon Nanotube Forest for Structured Lithium‐Ion Battery Electrodes
Small (IF 10.856) Pub Date : 2019-09-23 ,DOI:10.1002/smll.201901201
This is particularly challenging in systems requiring hybrid nanoparticle mixtures such as combinations of organic and inorganic materials. ...
Designing Next Generation of Photon Upconversion: Recent advances in Organic Triplet-triplet Annihilation Upconversion Nanoparticles
Biomaterials (IF 10.273) Pub Date : 2019-02-12 ,DOI:10.1016/j.biomaterials.2019.02.008
In this review, we focus on the latest breakthroughs in such new version of upconversion nanoparticle, including their design, preparation, and applications. ...
Extracellular vesicles based self-grown gold nanopopcorn for combinatorial chemo-photothermal therapy
Biomaterials (IF 10.273) Pub Date : 2019-01-14 ,DOI:10.1016/j.biomaterials.2019.01.024
The formulated nanopopcorn, consisting of self-grown gold nanoparticles and EVs encapsulated with DOX, retained the photothermal transduction from gold nanoparticle assemblies and cytotoxicity of DOX. ...
Self‐Assembly: Programmable Atom Equivalents: Atomic Crystallization as a Framework for Synthesizing Nanoparticle Superlattices (Small 26/2019)
Small (IF 10.856) Pub Date : 2019-06-26 ,DOI:10.1002/smll.201970139
In article number 1805424, Robert J. Macfarlane and co‐workers highlight the characteristics of DNA‐grafted nanoparticles as “Programmable Atom Equivalents” that enable controlled assembly behaviors analogous to atomic phenomena, which allow for rational material design well beyond what can be achieved with other crystallization techniques. ...
Optimizing PLG nanoparticle-peptide delivery platforms for transplantation tolerance using an allogeneic skin transplant model
Biomaterials (IF 10.273) Pub Date : 2019-05-01 ,DOI:10.1016/j.biomaterials.2019.04.030
A robust regimen for inducing allogeneic transplantation tolerance involves pre-emptive recipient treatment with donor splenocytes (SP) rendered apoptotic by 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide(ECDI) treatment. However, such a regimen is limited by availability of donor cells, cost of cell procurement, and regulatory hurdles associated with cell-based therapies. Nanoparticles (NP) delivering donor antigens are a promising alternative for promoting transplantation tolerance. Here, we used a B6.C-H-2bm12(bm12) to C57BL/6(B6) skin transplant model involving a defined major histocompatibility antigen mismatch to investigate design parameters of poly(lactide-co-glycolide) (PLG) NPs delivering peptides containing the donor antigen for optimizing skin allograft survival. We showed that an epitope-containing short peptide (P1) was more effective than a longer peptide (P2) at providing graft protection. Importantly, the NP and P1 complex (NP-ECDI-P1) resulted in a significant expansion of graft-infiltrating Tregs. Interestingly, in comparison to donor ECDI-SP that provided indefinite graft protection, NP-ECDI-P1 targeted different splenic phagocytes and skin allografts in these recipients harbored significantly more graft-infiltrating CD8+IFN-γ+ cells. Collectively, the current study provides initial engineering parameters for a cell-free and biocompatible NP-peptide platform for transplant immunoregulation. Moreover, it also provides guidance to future NP engineering endeavors to recapitulate the effects of donor ECDI-SP as a goal for maximizing tolerance efficacy of NP formulations. ...
Boston Ivy Disk‐Inspired Pressure‐Mediated Adhesive Film Patches
Small (IF 10.856) Pub Date : 2019-11-22 ,DOI:10.1002/smll.201904282
In analogy to the sticky disk of a mature ivy in which porous microchannels are occupied by catechol‐containing microgranules on the bound site, 3,4‐dihydroxylphenylalanine bolaamphiphile nanoparticle(DOPA‐C7 NP)‐coated alginate microgels are two‐dimensionally positioned into the cylindrical holes that ...
Design of Hierarchical Beads for Efficient Label‐Free Cell Capture
Small (IF 10.856) Pub Date : 2019-06-25 ,DOI:10.1002/smll.201902441
These hierarchical beads are built via electrostatic interaction, covalent bonding, and nanoparticleadherence. Further, after functionalization by hyaluronic acid (HA), the hierarchical beads display desirable surface hydrophilicity, biocompatibility, and chemical/structural stability. ...
Current state of the nanoscale delivery systems for temoporfin-based photodynamic therapy: Advanced delivery strategies
Journal of Controlled Release (IF 7.901) Pub Date : 2019-05-25 ,DOI:10.1016/j.jconrel.2019.05.035
The present review offers the description of different challenges and achievements in nanoparticle-based mTHPC delivery focusing on the synergetic combination of various nano-platforms to improve temoporfin delivery at all stages of biodistribution. ...
Discovery of and Insights into DNA “Codes” for Tunable Morphologies of Metal Nanoparticles
Small (IF 10.856) Pub Date : 2019-05-10 ,DOI:10.1002/smll.201900975
The resulting physical and chemical properties of these DNA encoded nanomaterials are also reviewed, while perspectives into the future directions of DNA‐mediated nanoparticle synthesis are provided. ...
Development of “CLAN” Nanomedicine for Nucleic Acid Therapeutics
Small (IF 10.856) Pub Date : 2019-03-18 ,DOI:10.1002/smll.201900055
With this in mind, a cationic lipid assisted PEG‐b‐PLA nanoparticle (CLAN) is designed that is capable of protecting nucleic acids via encapsulation inside the aqueous core, and delivers them to target cells, while maintaining or improving nucleic acid function. ...
Advanced in silico modeling explains pharmacokinetics and biodistribution of temoporfin nanocrystals in humans
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-24 ,DOI:10.1016/j.jconrel.2019.06.029
Furthermore, precipitation experiments were performed in presence of biorelevant media and precipitates were analyzed by nanoparticle tracking analysis. Size analysis and particle fraction were also incorporated in this model and a sensitivity analysis was performed. ...
Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer
Biomaterials (IF 10.273) Pub Date : 2019-06-23 ,DOI:10.1016/j.biomaterials.2019.119264
To improve antitumor therapeutic effects, we developed a novel polypyrrole nanoparticle using the near infrared dye IRDye800CW with camptothecin (CPT)-conjugated hyaluronic acid (HA) shell ([email protected]) and performed a photothermal therapy (PTT), along with chemotherapy, guided by fluorescence ...
Progress toward Understanding the Interactions between DNA Nanostructures and the Cell
Small (IF 10.856) Pub Date : 2019-02-20 ,DOI:10.1002/smll.201805416
This Review presents the recent progress in elucidating the “cell–nano” interactions of DNA nanostructures, with an emphasis on three key classes of structures commonly utilized in intracellular applications: tile‐based structures, origami‐based structures, and nanoparticle‐templated structures. ...
Plasmonic Crystal Transformation: Plasmon‐Driven Rapid In Situ Formation of Luminescence Single Crystal Nanoparticle (Small 34/2019)
Small (IF 10.856) Pub Date : 2019-08-23 ,DOI:10.1002/smll.201970183
In article number 1901286, Zhenglong Zhang, Hairong Zheng, and co‐workers develop a strategy to realize an easy and rapid in‐situ crystal transformation by plasmon‐induced thermal and catalysis effects, which is applicable even at low temperature. Such a scheme not only solves the bottleneck of the conventional approach of single crystal nanomaterial formation, but also extends the application of surface plasmons to a much broader field. ...
Co-delivery of therapeutic protein and catalase-mimic nanoparticle using a biocompatible nanocarrier for enhanced therapeutic effect
Journal of Controlled Release (IF 7.901) Pub Date : 2019-07-26 ,DOI:10.1016/j.jconrel.2019.07.038
Therapeutic proteins are indispensable in the treatment of various human diseases. Despite the many benefits of therapeutic proteins, they also exhibit diverse side effects. Therefore, reducing unwanted side effects of therapeutic proteins as well as enhancing their therapeutic efficacy are very important in developing therapeutic proteins. Urate oxidase (UOX) is a therapeutic enzyme that catalyzes the conversion of uric acid (UA) into a soluble metabolite, and it is used clinically for the treatment of hyperuricemia. Since UA degradation by UOX generates H2O2 (a cytotoxic side product), UOX was co-delivered with catalase-mimic nanoparticles (AuNPs) using biocompatible pluronic-based nanocarriers (NCs) to effectively reduce H2O2-associated toxicity in cultured cells and to enhance UA degradation efficiency in vivo. Simple temperature-dependent size changes of NCs allowed co-encapsulation of both UOX and AuNPs at a high loading efficiency without compromising critical properties, resulting in efficient modulation of a mixing ratio of UOX and AuNPs encapsulated in NCs. Co-localizing UOX and AuNPs in the NCs led to enhanced UA degradation and H2O2 removal in vitro, leading to a great reduction in H2O2-associated cytotoxicity compared with UOX alone or a free mixture of UOX and AuNPs. Furthermore, we demonstrated that co-delivery of UOX and AuNPs using NCs significantly improves in vivo UA degradation compared to simple co-injection of free UOX and AuNPs. More broadly, we showed that biocompatible pluronic-based nanocarriers can be used to deliver a target therapeutic protein along with its toxicity-eliminating agent in order to reduce side effects and enhance efficacy. ...
Dual and multi-targeted nanoparticles for site-specific brain drug delivery
Journal of Controlled Release (IF 7.901) Pub Date : 2019-11-30 ,DOI:10.1016/j.jconrel.2019.11.037
Furthermore, the background discussion of the basic properties of a brain-targeted nanoparticle and the common lesion features classified by neurological pathology are systematically summarized. ...
Universal Nanocarrier Ink Platform for Biomaterials Additive Manufacturing
Small (IF 10.856) Pub Date : 2019-11-25 ,DOI:10.1002/smll.201905421
The universal nanocarrier ink (UNI) leverages reversible polymer–nanoparticle interactions to form a transient physical network with shear‐thinning and self‐healing properties engineered for direct ink writing (DIW). ...
CT/Bioluminescence Dual‐Modal Imaging Tracking of Mesenchymal Stem Cells in Pulmonary Fibrosis
Small (IF 10.856) Pub Date : 2019-09-29 ,DOI:10.1002/smll.201904314
The rational design and development of a dual‐labeling strategy are reported by integrating gold nanoparticle (AuNP)‐based computed tomography (CT) nanotracers and red‐emitting firefly luciferase (RfLuc)‐based bioluminescence (BL) tags for CT/BL multimodal imaging tracking of the transplanted hMSCs in ...
Chemical modulation of siRNA lipophilicity for efficient delivery
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-21 ,DOI:10.1016/j.jconrel.2019.06.022
The application of lipophilic siRNA on nanoparticle delivery system is also covered. ...
Immobilized liquid metal nanoparticles with improved stability and photothermal performance for combinational therapy of tumor
Biomaterials (IF 10.273) Pub Date : 2019-04-01 ,DOI:10.1016/j.biomaterials.2019.03.043
Moreover, integrating the properties of easy surface functionalization and high drug loading efficiency from silica shell, immobilized LM nanoparticle was further used for photothermal involved combinational therapy. ...
Real‐Time Mapping of Ultratrace Singlet Oxygen in Rat during Acute and Chronic Inflammations via a Chemiluminescent Nanosensor
Small (IF 10.856) Pub Date : 2019-03-29 ,DOI:10.1002/smll.201804662
Here a distinct chemiluminescent (CL) nanosensor (NTPE‐PH) that boasts ultrahigh concentrated CL units in one nanoparticle is reported. ...
Nanoparticles: A High‐Throughput Automated Confocal Microscopy Platform for Quantitative Phenotyping of Nanoparticle Uptake and Transport in Spheroids (Small 37/2019)
Small (IF 10.856) Pub Date : 2019-09-11 ,DOI:10.1002/smll.201970197
In article number 1902033, Meritxell B. Cutrona and Jeremy C. Simpson describe a high‐throughput automated confocal microscopy platform which allows for the generation of multiple levels of quantitative information with respect to how nanoparticles interact with cells. These interactions can be measured at the subcellular level, cell spheroid level and spheroid population level. ...
Electroporation of a nanoparticle-associated DNA vaccine induces higher inflammation and immunity compared to its delivery with microneedle patches in pigs
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-29 ,DOI:10.1016/j.jconrel.2019.06.041
DNA vaccination is an attractive technology, based on its well-established manufacturing process, safety profile, adaptability to rapidly combat pandemic pathogens, and stability at ambient temperature; however an optimal delivery method of DNA remains to be determined. As pigs are a relevant model for humans, we comparatively evaluated the efficiency of vaccine DNA delivery in vivo to pigs using dissolvable microneedle patches, intradermal inoculation with needle (ID), surface electroporation (EP), with DNA associated or not to cationic poly-lactic-co-glycolic acid nanoparticles (NPs). We used a luciferase encoding plasmid (pLuc) as a reporter and vaccine plasmids encoding antigens from the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), a clinically-significant swine arterivirus. Patches were successful at inducing luciferase expression in skin although at lower level than EP. EP induced the cutaneaous recruitment of granulocytes, of MHC2posCD172Apos myeloid cells and type 1 conventional dendritic cells, in association with local production of IL-1β, IL-8 and IL-17; these local responses were more limited with ID and undetectable with patches. The addition of NP to EP especially promoted the recruitment of the MHC2posCD172Apos CD163int and CD163neg myeloid subsets. Notably we obtained the strongest and broadest IFNγ T-cell response against a panel of PRRSV antigens with DNA + NPs delivered by EP, whereas patches and ID were ineffective. The anti-PRRSV IgG responses were the highest with EP administration independently of NPs, mild with ID, and undetectable with patches. These results contrast with the immunogenicity and efficacy previously induced in mice with patches. This study concludes that successful DNA vaccine administration in skin can be achieved in pigs with electroporation and patches, but only the former induces local inflammation, humoral and cellular immunity, with the highest potency when NPs were used. This finding shows the importance of evaluating the delivery and immunogenicity of DNA vaccines beyond the mouse model in a preclinical model relevant to human such as pig and reveals that EP with DNA combined to NP induces strong immunogenicity. ...
Semiartificial Magnetotactic Bacteria: Nanoparticle‐Regulated Semiartificial Magnetotactic Bacteria with Tunable Magnetic Moment and Magnetic Sensitivity (Small 15/2019)
Small (IF 10.856) Pub Date : 2019-04-12 ,DOI:10.1002/smll.201970077
In article number 1900427, Xiuyu Wang, Li Yao, and co‐workers produce semi‐artificial magnetotactic bacteria (SAMTB) with synthetic magnetic nanoparticles on the surface of MTB. The SAMTB retain the advantages of strong mobility and magnetotaxis of natural MTB while realizing tunable magnetic properties and magnetotactic motion. ...
TiO2 and Co Nanoparticle‐Decorated Carbon Polyhedra as Efficient Sulfur Host for High‐Performance Lithium–Sulfur Batteries
Small (IF 10.856) Pub Date : 2019-01-20 ,DOI:10.1002/smll.201804533
Metal organic frameworks (MOFs)‐derived porous carbon is proposed as a promising candidate to develop novel, tailorable structures as polysulfides immobilizers for lithium–sulfur batteries because of their high‐efficiency electron conductive networks, open ion channels, and abundant central ions that can store a large amount of sulfur and trap the easily soluble polysulfides. However, most central ions in MOFs‐derived carbon framework are encapsulated in the carbon matrix so that their exposures as active sites to adsorb polysulfides are limited. To resolve this issue, highly dispersed TiO2 nanoparticles are anchored into the cobalt‐containing carbon polyhedras that are converted from ZIF‐67. Such a type of TiO2 and Co nanoparticles‐decorated carbon polyhedras (CCo/TiO2) provide more exposed active sites and much stronger chemical trapping for polysulfides, hence improving the sulfur utilization and enhancing reaction kinetics of sulfur‐containing cathode simultaneously. The sulfur‐containing carbon polyhedras decorated with TiO2 nanoparticles (S@CCo/TiO2) show a significantly improved cycling stability and rate capability, and deliver a discharge capacity of 32.9% higher than that of TiO2‐free S@CCo cathode at 837.5 mA g−1 after 200 cycles. ...
Simulations of the Oxidation and Degradation of Platinum Electrocatalysts
Small (IF 10.856) Pub Date : 2019-12-26 ,DOI:10.1002/smll.201905159
Improved understanding of the fundamental processes leading to degradation of platinum nanoparticleelectrocatalysts is essential to the continued advancement of their catalytic activity and stability. ...
Rapid and Digital Detection of Inflammatory Biomarkers Enabled by a Novel Portable Nanoplasmonic Imager
Small (IF 10.856) Pub Date : 2019-12-12 ,DOI:10.1002/smll.201906108
A novel portable biosensor based on nanoparticle‐enhanced digital plasmonic imaging is reported for rapid and sensitive detection of two sepsis‐related inflammatory biomarkers, procalcitonin (PCT) and C‐reactive protein (CRP) directly from blood serum. ...
Critical design criteria for engineering a nanoparticulate HIV-1 vaccine
Journal of Controlled Release (IF 7.901) Pub Date : 2019-11-28 ,DOI:10.1016/j.jconrel.2019.11.035
These include an optimal particle size below 100 nm, distances between two adjacent Env antigens of approximately 10–15 nm, an appropriate orientation of Env, and finally, the stability of both the Env attachment and the nanoparticle platform. ...
Reverting chemoresistance of targeted agents by a ultrasoluble dendritic nanocapsule
Journal of Controlled Release (IF 7.901) Pub Date : 2019-11-19 ,DOI:10.1016/j.jconrel.2019.11.020
Nanoparticle-modified drugs might disrupt chemoresistance by increasing dose exposure and altering resistance pathways, as administrated via the intravenous route to maximize efficacy. ...
Predicting Drug Release Kinetics from Nanocarriers inside Dialysis Bags
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-16 ,DOI:10.1016/j.jconrel.2019.09.016
Dialysis methods are frequently used to determine the in vitro drug release kinetics of nanoparticle drug delivery systems. However, the need for the released drug to diffuse through the dialysis membrane delays its appearance in the sampling compartment. ...
Liver-targeted Nano-MitoPBN normalizes glucose metabolism by improving mitochondrial redox balance
Biomaterials (IF 10.273) Pub Date : 2019-08-26 ,DOI:10.1016/j.biomaterials.2019.119457
Recent advances in Nanomedicine provide promising disease treatment through improved drug delivery efficiency, but clinical applications have encountered difficulties, largely due to the majority of injected nanoparticle is sequestered in liver. ...
Size‐Dependent Phase Transformation of Noble Metal Nanomaterials
Small (IF 10.856) Pub Date : 2019-08-22 ,DOI:10.1002/smll.201903253
It is found that the phase transformation is dependent on the ratio of the size of the monocrystalline nanoparticle (NP) to the diameter of 4H‐AuND. ...
Zwitterionic Janus Dendrimer with distinct functional disparity for enhanced protein delivery
Biomaterials (IF 10.273) Pub Date : 2019-05-31 ,DOI:10.1016/j.biomaterials.2019.119233
Zwitterionic peripheries on the counter dendron endow the nanoparticle (<20 nm) with a highly hydrophilic and antifouling surface, which efficiently prevents serum protein adsorption and exchange as demonstrated in biolayer interferometry assay, therefore, reducing premature protein release. ...
M13 Virus‐Based Framework for High Fluorescence Enhancement
Small (IF 10.856) Pub Date : 2019-05-27 ,DOI:10.1002/smll.201901233
Enhanced emission of cyanine 3 of up to 24‐fold is achieved by varying nanoparticle size and particle‐fluorophore separation. In addition, it is found that the fluorescence enhancement increases with increasing dye surface density on the viral capsid. ...
The Role of Temperature and Lipid Charge on Intake/Uptake of Cationic Gold Nanoparticles into Lipid Bilayers
Small (IF 10.856) Pub Date : 2019-04-23 ,DOI:10.1002/smll.201805046
Understanding the molecular mechanisms governing nanoparticle–membrane interactions is of prime importance for drug delivery and biomedical applications. ...
Molecular Imprinting with Functional DNA
Small (IF 10.856) Pub Date : 2019-02-13 ,DOI:10.1002/smll.201805246
Bulk imprinting, nanoparticle imprinting, and surface imprinting are all demonstrated with DNA. Since both DNA and synthetic polymers are cost effective and stable, their hybrid materials still possess such properties while enhancing the function of each component. ...
Recombinant Silk Fiber Properties Correlate to Prefibrillar Self‐Assembly
Small (IF 10.856) Pub Date : 2019-02-13 ,DOI:10.1002/smll.201805294
Tailoring of dope‐state spidroin nanoparticle assembly, thus, appears a promising strategy to modulate fibrillar silk properties. ...
Nucleus-targeted nano delivery system eradicates cancer stem cells by combined thermotherapy and hypoxia-activated chemotherapy
Biomaterials (IF 10.273) Pub Date : 2019-02-06 ,DOI:10.1016/j.biomaterials.2019.01.048
Herein, we designed a mesoporous silica nanoparticle (MSN)-based nucleus-targeted system, which could directly target the CSCs and further enter the nucleus by the surface modification of anti-CD133 and thermal-triggered exposure of TAT peptides under an alternating magnetic field (AMF). ...
Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo
Journal of Controlled Release (IF 7.901) Pub Date : 2019-01-10 ,DOI:10.1016/j.jconrel.2019.01.005
One proposed issue pertaining to the use of TfR-targeting in nanomedicines is the efficient tuning of the ligand density on the nanoparticle surface. ...
Pifithrin-μ incorporated in gold nanoparticle amplifies pro-apoptotic unfolded protein response cascades to potentiate synergistic glioblastoma therapy
Biomaterials (IF 10.273) Pub Date : 2019-12-11 ,DOI:10.1016/j.biomaterials.2019.119677
Conventional radiotherapy has a pivotal role in the treatment of glioblastoma; nevertheless, its clinical utility has been limited by radiation resistance. There is emerging evidence that upregulated heat shock protein A5 (HSPA5) in cancer cells maintains or restores the homeostasis of a cellular microenvironment and results in cancer resistance in various treatments. Therefore, we describe a bioresponsive nanoplatform that can deliver a HSPA5 inhibitor (pifithrin-μ, PES) and radiosensitizer (gold nanosphere, AuNS), to expand the synergistic photothermal therapy and radiotherapy, as well as to monitor the progression of cancer therapy using computer tomography/magnetic resonance imaging. The nanoplatform ([email protected], 63.3 ± 3.1 nm) comprises AuNS coated with the photothermal conversion agent polydopamine (PDA) for enhanced radiotherapy and photothermal therapy, as well as PES (loading efficiency of PES approximately 40%), a small molecular inhibitor against HSPA5 to amplify the pro-apoptotic unfolded protein response (UPR). The reported nanoplatform enables hyperthermia-responsive release of PES. Results from in vitro and in vivo studies demonstrate that [email protected] can specially activate pro-apoptotic UPR cascades, leading to remarkably improved radiotherapy and photothermal therapy efficiencies. Considered together, a versatile theranostic nanosystem is reported for promoting the synergistic radiophotothermal therapy by selectively activating pro-apoptotic UPR cascade pathways. ...
Reprogramming the T cell Response to Cancer by Simultaneous, Nanoparticle-mediated PD-L1 Inhibition and Immunogenic Cell Death
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-28 ,DOI:10.1016/j.jconrel.2019.10.047
In this study, dual drug-loaded nanoparticles were constructed to co-deliver low-dose doxorubicin (DOX) and miR-200c (DOX/miR-NPs) to inhibit programmed death-1 receptor (PD-L1) expression and trigger immunogenic cell death (ICD) in cancer cells. Two block copolymers, folic acid (FA)-conjugated PLGA-PEG (PLGA-PEG-FA) and PLGA-PEI, were formulated as folate-targeted NPs and loaded with DOX and miR-200c. The NPs, which were formed as nanosize objects (110.4 ± 2.1) with narrow size distribution (0.19 ± 0.02), effectively protected the miR-200c from degradation in serum. Modifying the NPs with FA increased not only their uptake by cancer cells in vitro but also their accumulation in tumor microenvironments in vivo, as compared with those properties of non-FA-modified NPs. The DOX/miR-NPs also exhibited efficacious inhibition of PD-L1 expression and robust induction of ICD in cancer cells in vitro and in vivo, resulting in increased dendritic cell maturation and CD8+ T cell response towards cancer cells. Furthermore, tumor growth was significantly inhibited by folate-targeted NPs loaded with the low-dose DOX/miR-200c combination, but not by treatments with free DOX, miR-NPs or DOX-NPs. Thus, our results suggest that simultaneous PD-L1 inhibition via microRNAs and the induction of an immunogenic tumor microenvironment via low-dose cytotoxic drugs may improve cancer therapy efficacy. ...
Hydration‐Driven Superlattices: Interplay between Short‐ and Long‐Ranged Forces Leading to the Formation of Ag Nanoparticle Superlattice (Small 33/2019)
Small (IF 10.856) Pub Date : 2019-08-16 ,DOI:10.1002/smll.201970175
During the self‐assembly process, the dynamic behavior of nanoparticles is correlated with the van der Waals force over both short (≈2–3 nm) and relatively long particle separations (<≈13 nm in this work). In article number 1901966, Jaehun Chun, Dongsheng Li, and co‐workers investigate how Ag nanoparticles self‐assemble into superlattices with short separations (<1 nm), which contribute to the hydration layers absorbed on the particle surface. ...
Improving Polysulfides Adsorption and Redox Kinetics by the Co4N Nanoparticle/N‐Doped Carbon Composites for Lithium‐Sulfur Batteries
Small (IF 10.856) Pub Date : 2019-05-09 ,DOI:10.1002/smll.201901454
Improved conductivity and suppressed dissolution of lithium polysulfides is highly desirable for high‐performance lithium‐sulfur (Li‐S) batteries. Herein, by a facile solvent method followed by nitridation with NH3, a 2D nitrogen‐doped carbon structure is designed with homogeneously embedded Co4N nanoparticles derived from metal organic framework (MOF), grown on the carbon cloth (MOF‐Co4N). Experimental results and theoretical simulations reveal that Co4N nanoparticles act as strong chemical adsorption hosts and catalysts that not only improve the cycling performance of Li‐S batteries via chemical bonding to trap polysulfides but also improve the rate performance through accelerating the conversion reactions by decreasing the polarization of the electrode. In addition, the high conductive nitrogen‐doped carbon matrix ensures fast charge transfer, while the 2D structure offers increased pathways to facilitate ion diffusion. Under the current density of 0.1C, 0.5C, and 3C, MOF‐Co4N delivers reversible specific capacities of 1425, 1049, and 729 mAh g−1, respectively, and retains 82.5% capacity after 400 cycles at 1C, as compared to the sample without Co4N (MOF‐C) values of 61.3% (200 cycles). The improved cell performance corroborates the validity of the multifunctional design of MOF‐Co4N, which is expected to be a potentially promising cathode host for Li‐S batteries. ...
Locally Trapping the C‐C Chemokine Receptor Type 7 by Gene Delivery Nanoparticle Inhibits Lymphatic Metastasis Prior to Tumor Resection
Small (IF 10.856) Pub Date : 2019-01-28 ,DOI:10.1002/smll.201805182
Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype. Currently, no targeted treatment is available for TNBC, and the most common clinical therapy is tumor resection, which often promotes metastasis risks. Strong evidence suggests that the lymphatic metastasis is mediated by the C‐C chemokine receptor type 7 (CCR7)/C‐C motif chemokine ligand 21 crosstalk between tumor cells and the lymphatic system. It is hypothesized that CCR7 is a key immune modulator in the tumor microenvironment and the local blockade of CCR7 could effectively inhibit TNBC lymphatic metastasis. Accordingly, a plasmid encoding an antagonistic CCR7 affinity protein‐CCR7 trap is delivered by tumor targeting nanoparticles in a highly metastatic 4T1 TNBC mouse model. Results show that CCR7 traps are transiently expressed, locally disrupt the signaling pathways in the tumor site, and efficiently inhibit TNBC lymphatic metastasis, without inducing immunosuppression as observed in systemic therapies using CCR7 monoclonal antibody. Significantly, upon applying CCR7 trap therapy prior to tumor resection, a 4T1 TNBC mouse model shows good prognosis without any further metastasis and relapse. In addition, CCR7 trap therapy efficiently inhibits the lymphatic metastasis in a B16F10 melanoma mouse model, indicating its great potential for various metastatic diseases treatment. ...
Radioluminescent nanoparticles for radiation-controlled release of drugs
Journal of Controlled Release (IF 7.901) Pub Date : 2019-04-23 ,DOI:10.1016/j.jconrel.2019.04.033
The non-toxic nature (absence of dark toxicity) of this drug-loaded polymer-encapsulated radioluminescent nanoparticle (“PEG-PLA/CWO/PTX”) formulation was confirmed by the MTT assay in cancer cell cultures. ...
Functional Nanocomplexes with Vascular Endothelial Growth Factor A/C Isoforms Improve Collateral Circulation and Cardiac Function
Small (IF 10.856) Pub Date : 2019-12-26 ,DOI:10.1002/smll.201905925
Crosslinked negatively charged heparin polysaccharide nanoparticle (HepNP) is proposed for protein delivery. HepNP can efficiently condense vascular endothelial growth factor (VEGF) because of the unique electronegative sulfonic acid and carboxyl domain of heparin. ...
Sonoprinting liposomes on tumor spheroids by microbubbles and ultrasound
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-29 ,DOI:10.1016/j.jconrel.2019.10.051
We have recently shown that upon applying ultrasound, nanoparticle-loaded microbubbles can deposit nanoparticles onto cells grown in 2D monolayers, through a process that we termed “sonoprinting”. ...
Exosomes influence the behavior of human mesenchymal stem cells on titanium surfaces
Biomaterials (IF 10.273) Pub Date : 2019-10-24 ,DOI:10.1016/j.biomaterials.2019.119571
EVs secreted by human adipose-derived MSCs were isolated by ultracentrifugation and analyzed using nanoparticle tracking analysis, Western blotting and relative quantitative mass spectrometry. ...
A systematic investigation of the effect of the fluid shear stress on Caco-2 cells towards the optimization of epithelial organ-on-chip models
Biomaterials (IF 10.273) Pub Date : 2019-09-25 ,DOI:10.1016/j.biomaterials.2019.119521
In the context of the intestinal epithelium, this detailed understanding of the effects of the FSS will enable the realization of in vitro organs-on-chip models with well-defined and tailored characteristics to a specific purpose, including for drug and nanoparticle absorption studies. ...
In vitro and in vivo evaluation of degradation, toxicity, biodistribution, and clearance of silica nanoparticles as a function of size, porosity, density, and composition
Journal of Controlled Release (IF 7.901) Pub Date : 2019-08-26 ,DOI:10.1016/j.jconrel.2019.08.028
It was shown nanoparticle porosity and composition as well as pH and ionic strength of the medium play the predominant roles for degradation of SiO2 NPs. Based on histological evaluations, at the injected doses investigated, the particles did not show toxicity. ...
Local Immunomodulation Using an Adhesive Hydrogel Loaded with miRNA‐Laden Nanoparticles Promotes Wound Healing
Small (IF 10.856) Pub Date : 2019-07-22 ,DOI:10.1002/smll.201902232
Overall, this study demonstrates the potential of nanoparticle‐laden hydrogels conveying miRNA‐223* to accelerate wound healing. ...
A pH-responsive platform combining chemodynamic therapy with limotherapy for simultaneous bioimaging and synergistic cancer therapy
Biomaterials (IF 10.273) Pub Date : 2019-06-05 ,DOI:10.1016/j.biomaterials.2019.119254
Herein, a multifunctional theranostic platform combing CDT with limotherapy was developed via nanoselenium (nano-Se)-coated manganese carbonate-deposited iron oxide nanoparticle (MCDION-Se). ...
Apoptotic cell-mimicking gold nanocages loaded with LXR agonist for attenuating the progression of murine systemic lupus erythematosus
Biomaterials (IF 10.273) Pub Date : 2019-01-23 ,DOI:10.1016/j.biomaterials.2019.01.034
Nanoparticle (NP)-based therapeutics have demonstrated efficacy in attenuating the progression of SLE. ...
Branched‐Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH
Small (IF 10.856) Pub Date : 2019-01-13 ,DOI:10.1002/smll.201805097
Here, a small library of lipidoid materials is used to elucidate structure–function relationships and identify a previously unappreciated parameter—lipid nanoparticle surface ionization—that correlates with mRNA delivery efficacy. ...
Hierarchically targetable polysaccharide-coated solid lipid nanoparticles as an oral chemo/thermotherapy delivery system for local treatment of colon cancer
Biomaterials (IF 10.273) Pub Date : 2019-01-09 ,DOI:10.1016/j.biomaterials.2019.01.019
The present study demonstrates the effective accumulation and cell uptake of the doxorubicin and superparamagnetic iron oxide nanoparticles-loaded solid lipid nanoparticle (SLN) delivery system for chemo/magnetothermal combination therapy at tumors by hierarchical targeting of folate (FA) and dextran ...
Ethanol‐Selectivity: AuCu Alloy Nanoparticle Embedded Cu Submicrocone Arrays for Selective Conversion of CO2 to Ethanol (Small 37/2019)
Small (IF 10.856) Pub Date : 2019-09-11 ,DOI:10.1002/smll.201970199
In article number 1902229, Jia He, Xijun Liu, and co‐workers report a self‐supported catalyst comprised of Cu submicrocone arrays hybridized with AuCu alloy nanoparticles for highly active CO2 electroreduction. The catalyst exhibits enhanced performance with high ethanol selectivity as well as excellent durability. This work can provide a fascinating insight into the construction of hybrid catalysts for electrocatalytic CO2 reduction to value‐added fuels in aqueous media. ...
Silver nanoparticle-adjuvanted vaccine protects against lethal influenza infection through inducing BALT and IgA-mediated mucosal immunity
Biomaterials (IF 10.273) Pub Date : 2019-06-26 ,DOI:10.1016/j.biomaterials.2019.119308
Most of current influenza virus vaccines fail to develop a strong immunity at lung mucosae (site of viral entry) due to sub-optimal vaccination protocols (e.g. inactivated virus administered by parenteral injections). Mucosal immunity could be improved by using locally-delivered vaccines containing appropriate adjuvants. Here we show, in a mouse model, that inclusion of silver nanoparticles (AgNPs) in virus-inactivated flu vaccine resulted in reduction of viral loads and prevention of excessive lung inflammation following influenza infection. Concomitantly, AgNPs enhanced specific IgA secreting plasma cells and antibodies titers, a hallmark of successful mucosal immunity. Moreover, vaccination in the presence of AgNPs but not with gold nanoparticles, protected mice from lethal flu. Compared with other commercial adjuvants (squalene/oil-based emulsion) or silver salts, AgNPs stimulated stronger antigen specific IgA production with lower toxicity by promoting bronchus-associated lymphoid tissue (BALT) neogenesis, and acted as a bona fide mucosal adjuvant. ...
SPION‐Decorated Exosome Delivered BAY55‐9837 Targeting the Pancreas through Magnetism to Improve the Blood GLC Response
Small (IF 10.856) Pub Date : 2019-11-27 ,DOI:10.1002/smll.201903135
In this study, a method for preparing BAY55‐9837‐loaded exosomes coupled with superparamagnetic iron oxide nanoparticle (SPIONs) with pancreas islet targeting activity and an enhanced blood GLC response with the help of an external magnetic force (MF) is demonstrated. ...
Co-localized delivery of nanomedicine and nanovaccine augments the postoperative cancer immunotherapy by amplifying T-cell responses
Biomaterials (IF 10.273) Pub Date : 2019-11-22 ,DOI:10.1016/j.biomaterials.2019.119649
The cancer nanovaccine composed of antigenic peptide, CpG-ODN and cationic polymer nanoparticlesignificantly triggered the maturation of dendritic cells (DCs) and elicited potent vaccine-specific T-cell immune responses. ...
Nitrogen‐Doped Graphene‐Buffered Mn2O3 Nanocomposite Anodes for Fast Charging and High Discharge Capacity Lithium‐Ion Batteries
Small (IF 10.856) Pub Date : 2019-11-14 ,DOI:10.1002/smll.201903311
In this work, Mn2O3 with 1D nanowire geometry is synthesized in neutral aqueous solutions by a facile and effective hydrothermal strategy for the first time, and then Mn2O3 nanoparticle and nitrogen‐doped reduced graphene oxide (N‐rGO) are composited with Mn2O3 nanowires (Mn2O3‐GNCs) to enhance its volume ...
A cerium oxide loaded glycol chitosan nano-system for the treatment of dry eye disease
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-24 ,DOI:10.1016/j.jconrel.2019.10.039
We developed a water soluble cerium oxide loaded glycol chitosan nanoparticle as a new type of eye drop, namely GCCNP (glycol chitosan cerium oxide nanoparticles). GCCNP is capable of scavenging cellular reactive oxygen species (ROS) for the treatment of DE disease. ...
Targeted delivery of anti-inflammatory cytokine by nanocarrier reduces atherosclerosis in Apo E−/- mice
Biomaterials (IF 10.273) Pub Date : 2019-10-15 ,DOI:10.1016/j.biomaterials.2019.119550
These results signify the prospect of nanoparticle based cytokine delivery for preventing atherosclerotic through inflammation modulation in near future. ...
Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress
Biomaterials (IF 10.273) Pub Date : 2019-09-11 ,DOI:10.1016/j.biomaterials.2019.119467
The goal of this study was to engineer a nanoparticle system capable of sustained retention in the joint space, localization to cartilage, and mitigation of oxidative stress. ...
ZnS/C/MoS2 Nanocomposite Derived from Metal–Organic Framework for High‐Performance Photo‐Electrochemical Immunosensing of Carcinoembryonic Antigen
Small (IF 10.856) Pub Date : 2019-07-30 ,DOI:10.1002/smll.201902086
A sandwich‐type PEC immunosensor is fabricated by immobilizing CEA antibody (Ab1) onto the ZnS/C/MoS2/GCE surface, subsequently binding CEA and the alkaline phosphatase‐gold nanoparticlelabeled CEA antibody (ALP‐Au‐Ab2). ...
Exploring molecular dynamics simulation to predict binding with ocular mucin: An in silico approach for screening mucoadhesive materials for ocular retentive delivery systems
Journal of Controlled Release (IF 7.901) Pub Date : 2019-07-26 ,DOI:10.1016/j.jconrel.2019.07.037
The corresponding in vitro assessment by spectrophotometry and nanoparticle tracking analysis showed a similar outcome wherein COS was found to be extensively mucoadhesive, followed by both STA and CTAB, which showed mucoadhesion to a nearly equal extent. ...
Shape‐Defined Hollow Structural Co‐MOF‐74 and Metal Nanoparticles@Co‐MOF‐74 Composite through a Transformation Strategy for Enhanced Photocatalysis Performance
Small (IF 10.856) Pub Date : 2019-07-15 ,DOI:10.1002/smll.201902287
To promote the MOFs' function and performance, the construction of hollow structural metal–organic frameworks and nanoparticle–MOF composites is significantly effective but remains a considerable challenge. ...
Gold-caged copolymer nanoparticles as multimodal synergistic photodynamic/photothermal/chemotherapy platform against lethality androgen-resistant prostate cancer
Biomaterials (IF 10.273) Pub Date : 2019-05-08 ,DOI:10.1016/j.biomaterials.2019.05.009
Given that there is no effective treatment method for lethality androgen-resistant prostate cancers (ARPC), herein we report a multifunctional gold-caged nanoparticle (PTX-PP@Au NPs) against ARPC through integrating functional organic/inorganic materials to exploit the superiors of gold particles such ...
Sub‐10 nm Ag Nanoparticles/Graphene Oxide: Controllable Synthesis, Size‐Dependent and Extremely Ultrahigh Catalytic Activity
Small (IF 10.856) Pub Date : 2019-04-26 ,DOI:10.1002/smll.201901701
While tremendous advancements in Ag nanoparticle (AgNP)‐based materials have been made, the development of a facile protocol for preparing sub‐10 nm AgNPs with controllable size and ultrahigh performance remains a formidable challenge. ...
Oxygenated theranostic nanoplatforms with intracellular agglomeration behavior for improving the treatment efficacy of hypoxic tumors
Biomaterials (IF 10.273) Pub Date : 2019-01-04 ,DOI:10.1016/j.biomaterials.2019.01.002
The hydrophilic moiety would be subsequently shed by the intratumoral GSH after cellular internalization and result in the agglomeration of nanocarriers inside tumor cells, consequently impeding the nanoparticle exocytosis to enhance their intracellular retention. ...
Solid lipid nanoparticle-based dissolving microneedles: A promising intradermal lymph targeting drug delivery system with potential for enhanced treatment of lymphatic filariasis
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-23 ,DOI:10.1016/j.jconrel.2019.10.004
Conventional oral therapy of lymphatic filariasis drugs is only effective to kill microfilariae in the bloodstream, but is often ineffective to kill adult filarial (macrofilariae) in the complex anatomy of the lymphatic system. The encapsulation of drugs into lipid-based nanoparticles with sizes of <100 nm, and administration intradermally, could be used to enhance lymphatic uptake. Therefore, we developed an innovative approach, using solid lipid nanoparticles (SLNs) and dissolving microneedles (MNs) to deliver antifilariasis drugs, namely doxycycline, diethylcarbamazine and albendazole, intradermally. The SLNs were prepared from Geleol® and Tween®80 as a lipid matrix and stabilizer, respectively. The formulations were optimized using a central composite design, producing SLNs with sizes of <100 nm. Drug release was sustained over 48 h from SLNs, compared to pure drugs. The SLNs were then incorporated into a polymeric hydrogel which was casted to form SLNs-loaded MNs. SLNs-loaded MNs exhibited sufficient mechanical and insertion properties. Importantly, dermatokinetic studies showed that >40% of drugs were retained in the dermis of excised neonatal porcine skin up to 24 h post-MN application, indicating the high possibility of the SLNs to be taken by the lymphatic system. In in vivo studies, the maximal lymph concentrations of the three drugs in rat, achieved following intradermal delivery, ranged between 4- and 7-fold higher than that recorded after oral administration. Additionally, compared to oral administration, despite the lower plasma Cmax and organ-distribution, the AUC and relative bioavailability of the three drugs in rat plasma was also higher using our delivery approach. Accordingly, this delivery approach could maximize the drugs concentrations in the lymph system without essentially increasing their plasma concentrations. This could potentially deliver the drugs efficiently to the bloodstream, where the microfilariae reside, while also targeting drug to the lymph nodes, where filarial nematodes reside in infected patients, leading to an effective therapy for lymphatic filariasis. ...
Tandem activated photodynamic and chemotherapy: Using pH-Sensitive nanosystems to realize different tumour distributions of photosensitizer/prodrug for amplified combination therapy
Biomaterials (IF 10.273) Pub Date : 2019-07-27 ,DOI:10.1016/j.biomaterials.2019.119393
Overall, we report a nanoparticle guided by MRI and fluorescence imaging possesses of tandem active pattern of PDT and chemotherapy, which is promising for future clinical diagnosis and treatment. ...
A tetrameric protein scaffold as a nano-carrier of antitumor peptides for cancer therapy
Biomaterials (IF 10.273) Pub Date : 2019-03-06 ,DOI:10.1016/j.biomaterials.2019.03.004
A major pharmacological barrier to peptide therapeutics is their susceptibility to proteolytic degradation and poor membrane permeability, which, in principle, can be overcome by nanoparticle-based delivery technologies. ...
Construction of lanthanide-doped upconversion nanoparticle-Uelx Europaeus Agglutinin-I bioconjugates with brightness red emission for ultrasensitive in vivo imaging of colorectal tumor
Biomaterials (IF 10.273) Pub Date : 2019-05-08 ,DOI:10.1016/j.biomaterials.2019.05.010
Lanthanide-doped upconversion nanoparticles (UCNPs)-based active targeting optical bioimaging has attracted tremendous scientific interest because of its noninvasive real-time signal feedback, superior tissue penetration depth and high spatial resolution in early diagnosis of disease. Herein, we synthesize a novel carboxy-terminated silica coated NaErF4: 10% Yb@NaYF4: 40% Yb@NaNdF4: 10% Yb@NaGdF4: 20% Yb UCNPs (termed as UCNP@SiO2-COOH) with 808 nm near-infrared (NIR) excitation and bright 655 nm upconversion luminescence (UCL) emission for realizing deep tissue imaging. Under 808 nm NIR laser excitation (1.5 W cm−2), the UCL of UCNP@SiO2-COOH with relative low concentration (2 mg mL−1) can be successfully visualized under a chicken breast slice with 10 mm thickness. After conjugated with various molecules including NH2-PEG3400-COOH, peptide D-SP5 and Uelx Europaeus Agglutinin-I (UEA-I), biodistributions, clearance pathways and tumor-targeting capacities of the UCNP@SiO2-COOH and corresponding bioconjugates (termed as UCNP@SiO2-PEG, UCNP@SiO2-D-SP5 and UCNP@SiO2-UEA-I, respectively) were investigated by tracking the UCL intensities of livers, kidneys and tumors. Both of in vitro and in vivo experimental results reveal that there is no significant difference for their in vivo biodistributions and clearance pathways. The UCNP@SiO2-UEA-I exhibits much higher SW480 tumor-targeting capacity than those of other bioconjugates. In particular, the as-prepared UCNP@SiO2-UEA-I even to visualize ultrasmall (c.a. 3 mm3 in volume) subcutaneous SW480 tumor in Balb/c nude mouse through intravenous administration. The study implies that the red UCL emitted UCNPs with a minimized heating effect is suitable for deep tissue biomedical imaging and UCNP@SiO2-UEA-I can serve as an efficient optical probe for early diagnosis of SW480 tumor. ...
Delivery of RALA/siFKBPL Nanoparticles via Electrospun Bilayer Nanofibres: an innovative angiogenic therapy for wound repair
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-30 ,DOI:10.1016/j.jconrel.2019.10.050
Subsequently, the nanofibres were crosslinked to improve stability, before nanoparticle incorporation via soak loading. ...
Laser-triggered polymeric lipoproteins for precision tumor penetrating theranostics
Biomaterials (IF 10.273) Pub Date : 2019-08-06 ,DOI:10.1016/j.biomaterials.2019.119413
Therefore, the described bio-strategy opens new avenues for creating polymeric lipoproteins with varied hybrid functionalities, which may be applied to provide a basis and inspiration for improved nanoparticle-based precision theranostic nanoplatforms. ...
Ultrasound/microbubble-mediated targeted delivery of anticancer microRNA-loaded nanoparticles to deep tissues in pigs
Journal of Controlled Release (IF 7.901) Pub Date : 2019-07-18 ,DOI:10.1016/j.jconrel.2019.07.024
Additionally, we used highly fluorescent semiconducting polymer nanoparticles to visually assess nanoparticle extravasation. Fluorescent microscopy suggested the presence of nanoparticles in the extravascular compartment. ...
Magnetic-responsive and targeted cancer nanotheranostics by PA/MR bimodal imaging-guided photothermally triggered immunotherapy
Biomaterials (IF 10.273) Pub Date : 2019-07-18 ,DOI:10.1016/j.biomaterials.2019.119370
While theranostic nanoparticle (TNP)-based photothermal therapy (PTT) exhibits prominent promise for cancer therapy, metastatic cancers remain one of the main obstacles of effective PTT. ...
Widespread gene transfer to malignant gliomas with In vitro-to-In vivo correlation
Journal of Controlled Release (IF 7.901) Pub Date : 2019-04-09 ,DOI:10.1016/j.jconrel.2019.04.010
Specifically, this brain-penetrating nanoparticle (BPN), following intracranial administration via convection enhanced delivery (CED), provides widespread transgene expression in heathy rodent striatum and an aggressive brain tumor tissue established orthotopically in rats. ...
Ultrasmall Cu2-xS nanodots as photothermal-enhanced Fenton nanocatalysts for synergistic tumor therapy at NIR-II biowindow
Biomaterials (IF 10.273) Pub Date : 2019-03-16 ,DOI:10.1016/j.biomaterials.2019.03.014
This work not only provides a nanoparticle-augmented synergistic cancer-therapeutic modality, but also enriches the totally new nanocatalyst types for catalytic Fenton reaction-based nanocatalytic tumor therapy. ...
Mucus penetration enhanced lipid polymer nanoparticles improve the eradication rate of Helicobacter pylori biofilm
Journal of Controlled Release (IF 7.901) Pub Date : 2019-02-28 ,DOI:10.1016/j.jconrel.2019.02.039
LPNs employed chitosan nanoparticle (CS NPs) as the core, mixed lipid layer containing rhamnolipids (RHL) as the shell and the surface of LPNs was further modified with DSPE-PEG2000 to improve hydrophilicity. Clarithromycin (CLR), a first-line drug for H. pylori infection, was encapsulated in LPNs. ...
Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells
Journal of Controlled Release (IF 7.901) Pub Date : 2019-01-09 ,DOI:10.1016/j.jconrel.2019.01.006
Second, a 20 nm gold nanoparticle (AuNP) was decorated with ~65 uPICs through AuS bonding. ...
Sodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin
Journal of Controlled Release (IF 7.901) Pub Date : 2019-01-05 ,DOI:10.1016/j.jconrel.2019.01.004
Analyzing nanoparticle biodistribution within the tumor tissue revealed that 93% of the PEGylated liposomes accumulated in the extracellular matrix, while 7% were detected intracellularly. Mice administered bicarbonate-loaded liposomes reached an intra-tumor pH value of 7.38 ± 0.04. ...
Measuring particle size distribution of nanoparticle enabled medicinal products, the joint view of EUNCL and NCI-NCL. A step by step approach combining orthogonal measurements with increasing complexity
Journal of Controlled Release (IF 7.901) Pub Date : 2019-02-21 ,DOI:10.1016/j.jconrel.2019.02.030
The particle size distribution (PSD) and the stability of nanoparticles enabled medicinal products (NEP) in complex biological environments are key attributes to assess their quality, safety and efficacy. Despite its low resolution, dynamic light scattering (DLS) is the most common sizing technique since the onset of NEP in pharmaceutical technologies. Considering the limitations of the existing sizing measurements and the challenges posed by complex NEPs both scientists and regulators encourage the combination of multiple orthogonal high-resolution approaches to shed light in the NEP sizing space (e.g. dynamic light scattering, electron microscopy, field flow fractionation coupled to online sizing detectors, centrifugal techniques, particle tracking analysis and tunable resistive pulse sensing). The pharmaceutical and biotechnology developers are now challenged to find their own pragmatic characterisation approaches, which should be fit for purpose and minimize costs at the same time, in a complicated landscape where only a few standards exist. In order to support the community, the European Nanomedicine Characterisation Laboratory (EUNCL) and the US National Cancer Institute Nanotechnology Characterisation Laboratory (NCI-NCL) have jointly developed multiple standard operating procedures (SOPs) for NEP assessment, including the measurements of particle size distribution, and are offering wide access to their ‘state of the art’ characterisation platforms, in addition to making SOPs publicly available. This joint perspective article would like to present the NCI-NCL and EUNCL multi-step approach of incremental complexity to measure particle size distribution and size stability of NEPs, consisting of a quick preliminary step to assess sample integrity and stability by low resolution techniques (pre-screening), followed by the combination of complementary high resolution sizing measurements performed both in simple buffers and in complex biological media. Test cases are presented to demonstrate: i) the need for employing at least one high-resolution sizing technique, ii) the importance of selecting the correct sizing techniques for the purpose, and iii) the robustness of utilizing orthogonal sizing techniques to study the physical properties of complex NEP samples. ...
Development of a lipoplex-type mRNA carrier composed of an ionizable lipid with a vitamin E scaffold and the KALA peptide for use as an ex vivo dendritic cell-based cancer vaccine
Journal of Controlled Release (IF 7.901) Pub Date : 2019-08-03 ,DOI:10.1016/j.jconrel.2019.08.002
We previously reported on an ionizable lipid-like material with vitamin E-scaffolds (ssPalmE) as a material for a lipid nanoparticle (LNP)-based carrier for nucleic acids. ...
Superparamagnetic iron oxide nanoparticles of curcumin enhance gemcitabine therapeutic response in pancreatic cancer
Biomaterials (IF 10.273) Pub Date : 2019-04-08 ,DOI:10.1016/j.biomaterials.2019.04.005
We have recently developed a superparamagnetic iron oxide nanoparticle (SPION) formulation of curcumin (SP-CUR), which is a nontoxic, bioactive anti-inflammatory/anti-cancer agent for its enhanced delivery in tumors. ...
A multifunctional lipid that forms contrast-agent liposomes with dual-control release capabilities for precise MRI-guided drug delivery
Biomaterials (IF 10.273) Pub Date : 2019-08-06 ,DOI:10.1016/j.biomaterials.2019.119412
Monitoring of nanoparticle-based therapy in vivo and controlled drug release are urgently needed for the precise treatment of disease. We have synthesized a multifunctional Gd-DTPA-ONB (GDO) lipid by introducing the Gd-DTPA contrast agent moiety into an o-nitro-benzyl ester lipid. ...
Extracellular vesicle (ECV)-modified polyethylenimine (PEI) complexes for enhanced siRNA delivery in vitro and in vivo
Journal of Controlled Release (IF 7.901) Pub Date : 2019-12-19 ,DOI:10.1016/j.jconrel.2019.12.032
We conclude that ECV-modification enhances the activity of PEI-based complexes, by altering pivotal physicochemical and biological nanoparticle properties. ...
Intranasal delivery of targeted polyfunctional gold–iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide
Biomaterials (IF 10.273) Pub Date : 2019-07-12 ,DOI:10.1016/j.biomaterials.2019.119342
These nanoformulations would thus allow presensitization of GBM cells to the systemically delivered chemotherapy drug temozolomide (TMZ), as well as in vivo multimodality molecular and anatomic imaging of nanoparticle delivery, trafficking, and treatment effects. ...
Systemic delivery of a Gli inhibitor via polymeric nanocarriers inhibits tumor-induced bone disease
Journal of Controlled Release (IF 7.901) Pub Date : 2019-09-05 ,DOI:10.1016/j.jconrel.2019.08.038
We therefore developed a micellar nanoparticle (NP) to encapsulate and colloidally stabilize GANT58, providing a fully aqueous, intravenously injectable formulation based on the polymer poly(propylene sulfide)135-b-poly[(oligoethylene glycol)9 methyl ether acrylate]17 (PPS135-b-POEGA17). ...
Coated cationic lipid-nanoparticles entrapping miR-660 inhibit tumor growth in patient-derived xenografts lung cancer models
Journal of Controlled Release (IF 7.901) Pub Date : 2019-07-09 ,DOI:10.1016/j.jconrel.2019.07.006
Interestingly, lipid-nanoparticle delivery of synthetic miR-660 had no immunological off-target or acute/chronic toxic effects on immunocompetent mice. ...

Atomic insight into hydration shells around facetted nanoparticles
Nature Communications (IF 11.878) Pub Date : 2019-03-01 ,DOI:10.1038/s41467-019-09007-1
For this, we synthesize variably functionalized magnetic iron oxide nanoparticle dispersions. ...
On-Demand Intracellular Delivery of Single Particles in Single Cells by 3D Hollow Nanoelectrodes
Nano Letters (IF 12.279) Pub Date : 2019-01-23 ,DOI:10.1021/acs.nanolett.8b03764
The gold-coated hollow nanoelectrode capable of confinement and enhancement of electromagnetic fields upon laser illumination can distinguish the SERS signals of a single nanoparticle flowing through the nanoelectrode. ...
A novel Granzyme B nanoparticle delivery system simulates immune cell functions for suppression of solid tumors
Theranostics (IF 8.063) Pub Date : 2019-10-14 ,DOI:10.7150/thno.35900
Cell-based immunotherapy for the treatment of hematologic malignancies, such as leukemia and lymphoma, has seen much success and played an increasingly important role in clinical studies. Nevertheless, the efficacy of immunotherapy in solid tumors still needs improvements due to the immunosuppressive properties of tumor cells and the microenvironment. To overcome these limitations, we prepared a novel tumor-targeting delivery system based on the underlying mechanism of immune-targeted cell death that encapsulated granzyme B protein within a porous polymeric nanocapsule. Methods: A cell-penetrating peptide TAT was attached onto granzyme B (GrB) to enhance its transmembrane transport efficiency and potency to induce cell apoptosis. The endocytosis and internalization pathways of GrB-TAT (GrB-T) were analyzed in comparison with perforin by confocal microscopy and flow cytometry. Furthermore, the positively charged GrB-T was wrapped into nanoparticles by p-2-methacryloyloxy ethyl phosphorylcholine (PMPC)-modified HA (hyaluronic acid). The nanoparticles (called TCiGNPs) were characterized in terms of zeta potential and by transmission electron microscopy (TEM). The in vitro anti-tumor effects of GrB-T were examined by cell apoptosis assay and Western blotting analysis. The in vivo anti-tumor therapeutic efficacy of TCiGNPs was evaluated in a mouse tumor model. Results: The TAT peptide could play a role similar to perforin to mediate direct transmembrane transfer of GrB and improve GrB-induced cell apoptosis. The TCiGNPs were successfully synthesized and accumulated in the solid tumor through enhanced permeability and retention (EPR) effect. In the tumor microenvironment, TCiGNPs could be degraded by hyaluronidase and triggered the release of GrB-T. The TAT peptide enabled the translocation of GrB across the plasma membrane to induce tumor cell apoptosis in vivo. Conclusion: We successfully developed a granzyme B delivery system with a GrB-T core and a PMPC/HA shell that simulated CTL/NK cell-mediated cancer immunotherapy mechanism. The GrB delivery system holds great promise for cancer treatment analogous to the CTL/NK cell-induced immunotherapy. Keywords: Granzyme B delivery, tumor therapy, nanoparticles, biomimetics ...
Metal-Organic Framework Nanoparticle-Based Biomineralization: A New Strategy toward Cancer Treatment
Theranostics (IF 8.063) Pub Date : 2019-05-18 ,DOI:10.7150/thno.33539
Cancer treatment using functional proteins, DNA/RNA, or complex bio-entities is important in both preclinical and clinical studies. With the help of nano-delivery systems, these biomacromolecules can enrich cancer tissues to match the clinical requirements. Biomineralization via a self-assembly process has been widely applied to provide biomacromolecules exoskeletal-like protection for immune shielding and preservation of bioactivity. Advanced metal-organic framework nanoparticles (MOFs) are excellent supporting matrices due to the low toxicity of polycarboxylic acids and metals, high encapsulation efficiency, and moderate synthetic conditions. In this review, we study MOFs-based biomineralization for cancer treatment and summarize the unique properties of MOF hybrids. We also evaluate the outlook of potential cancer treatment applications for MOFs-based biomineralization. This strategy likely opens new research orientations for cancer theranostics. Keywords: metal-organic framework, biomineralization, cancer treatment, theranostics ...
Unravelling inherent electrocatalysis of mixed-conducting oxide activated by metal nanoparticle for fuel cell electrodes
Nature Nanotechnology (IF 33.407) Pub Date : 2019-02-18 ,DOI:10.1038/s41565-019-0367-4
Highly active metal nanoparticles are desired to serve in high-temperature electrocatalysis, for example, in solid oxide electrochemical cells. Unfortunately, the low thermal stability of nanosized particles and the sophisticated interface requirement for electrode structures to support concurrent ionic and electronic transport make it hard to identify the exact catalytic role of nanoparticles embedded within complex electrode architectures. Here we present an accurate analysis of the reactivity of oxide electrodes boosted by metal nanoparticles, where all particles participate in the reaction. Monodisperse particles (Pt, Pd, Au and Co), 10 nm in size and stable at high temperature (more than 600 °C), are uniformly distributed onto mixed-conducting oxide electrodes as a model electrochemical cell via self-assembled nanopatterning. We identify how the metal catalysts activate hydrogen electrooxidation on the ceria-based electrode surface and quantify how rapidly the reaction rate increases with proper choice of metal. These results suggest an ideal electrode design for high-temperature electrochemical applications. ...
Evaluation of Turning-Sized Gold Nanoparticles on Cellular Adhesion by Golgi Disruption in Vitro and in Vivo
Nano Letters (IF 12.279) Pub Date : 2019-11-20 ,DOI:10.1021/acs.nanolett.9b02826
This work is significant to nanoparticle research because it illustrates the important role of size on Au NP-induced changes in Golgi morphology and their consequences in vitro and in vivo, which has important implications for the biological applications of nanomaterials. ...
Tunable assembly of truncated nanocubes by evaporation-driven poor-solvent enrichment
Nature Communications (IF 11.878) Pub Date : 2019-09-17 ,DOI:10.1038/s41467-019-12237-y
Poor-solvent enrichment is a versatile nanoparticle assembly method that offers a promising production route with high predictability to modulate and maximize the size and morphology of nanocrystal metamaterials. ...
General Approach to the Synthesis of Heterodimers of Metal Nanoparticles through Site-Selected Protection and Growth
Nano Letters (IF 12.279) Pub Date : 2019-08-29 ,DOI:10.1021/acs.nanolett.9b03167
When styrene is polymerized in the presence of Au nanoparticles, the resultant polystyrene (PS) can be controlled to grow from only one portion of the surface of a nanoparticle. ...
Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles
Nature Communications (IF 11.878) Pub Date : 2019-07-25 ,DOI:10.1038/s41467-019-11235-4
The bLP-mediated TECA strategy provides deeper insights into enhancing nanoparticle accessibility to cancer cells for antitumor therapy. ...
Versatile Functionalization of Ferritin Nanoparticles by Intein-Mediated Trans-Splicing for Antigen/Adjuvant Co-delivery
Nano Letters (IF 12.279) Pub Date : 2019-07-03 ,DOI:10.1021/acs.nanolett.9b01974
Here, we report an intein-mediated trans-splicing approach that overcomes the detrimental effects of loaded proteins on ferritin nanoparticle stability and allows concurrent display of antigen and adjuvant in a facile, efficient, and site-specific manner. ...
Electrosynthesis of high-entropy metallic glass nanoparticles for designer, multi-functional electrocatalysis
Nature Communications (IF 11.878) Pub Date : 2019-06-14 ,DOI:10.1038/s41467-019-10303-z
Integrating dissimilar metals into a single nanoparticle (NP) offers a unique avenue for customizing catalytic activity and maximizing surface area. ...
Partitioning surface ligands on nanocrystals for maximal solubility
Nature Communications (IF 11.878) Pub Date : 2019-06-05 ,DOI:10.1038/s41467-019-10389-5
A typical colloidal nanoparticle can be viewed as a nanocrystal-ligands complex with an inorganic single-crystalline core, the nanocrystal, bonded with a monolayer of organic ligands. The surface chemistry of nanocrystal-ligands complexes is crucial to their bulk properties. ...
Nonreciprocal Asymmetric Polarization Encryption by Layered Plasmonic Metasurfaces
Nano Letters (IF 12.279) Pub Date : 2019-05-09 ,DOI:10.1021/acs.nanolett.9b01298
However, single layer metasurface systems consisting of two-dimensional nanoparticle arrays exhibit only a weak spatial asymmetry perpendicular to the surface and therefore have mostly symmetric transmission features. ...
Integrating temporal and spatial control of electronic transitions for bright multiphoton upconversion
Nature Communications (IF 11.878) Pub Date : 2019-04-18 ,DOI:10.1038/s41467-019-09850-2
A NaErF4@NaYF4 core−shell nanoparticle is constructed to host the upconversion process for minimizing non-radiative dissipation of excitation energy by surface quenchers. ...
Bright sub-20-nm cathodoluminescent nanoprobes for electron microscopy
Nature Nanotechnology (IF 33.407) Pub Date : 2019-03-04 ,DOI:10.1038/s41565-019-0395-0
Our results suggest that the optimization of nanoparticle composition, synthesis protocols and electron imaging conditions can lead to sub-20-nm nanolabels that would enable high signal-to-noise localization of individual biomolecules within a cellular context. ...
Hot Holes Assist Plasmonic Nanoelectrode Dissolution
Nano Letters (IF 12.279) Pub Date : 2019-01-15 ,DOI:10.1021/acs.nanolett.8b04894
The results provide new insights into hot-hole-driven processes with relevance to photocatalysis while emphasizing the need for statistical descriptions of nonequilibrium processes on innately heterogeneous nanoparticle supports. ...
Introducing Specificity to Iron Oxide Nanoparticle Imaging by Combining 57Fe-Based MRI and Mass Spectrometry
Nano Letters (IF 12.279) Pub Date : 2019-10-02 ,DOI:10.1021/acs.nanolett.9b03016
Iron oxide nanoparticles (ION) are highly sensitive probes for magnetic resonance imaging (MRI) that have previously been used for in vivo cell tracking and have enabled implementation of several diagnostic tools to detect and monitor disease. However, the in vivo MRI signal of ION can overlap with the signal from endogenous iron, resulting in a lack of detection specificity. Therefore, the long-term fate of administered ION remains largely unknown, and possible tissue deposition of iron cannot be assessed with established methods. Herein, we combine nonradioactive 57Fe-ION MRI with ex vivo laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) imaging, enabling unambiguous differentiation between endogenous iron (56Fe) and iron originating from applied ION in mice. We establish 57Fe-ION as an in vivo MRI sensor for cell tracking in a mouse model of subcutaneous inflammation and for assessing the long-term fate of 57Fe-ION. Our approach resolves the lack of detection specificity in ION imaging by unambiguously recording a 57Fe signature. ...
pH and Thermal Dual-Sensitive Nanoparticle-Mediated Synergistic Antitumor Effect of Immunotherapy and Microwave Thermotherapy
Nano Letters (IF 12.279) Pub Date : 2019-07-10 ,DOI:10.1021/acs.nanolett.9b01061
Cationic anticancer peptides, which can induce tumor cell immunogenic death and further promote systemic tumor-specific immune responses, have offered a promising solution to relieve the tumor immunosuppressive microenvironment. However, peptide drugs are easily degraded and lack of targeting ability when administered systemically, leading to limitations in their applications. Herein, we report a pH and thermal dual-sensitive bovine lactoferricin-loaded (one of the most widely studied cationic anticancer peptides) nanoparticles, which simultaneously exhibited antitumor and immune cell activated effects when applied with microwave thermotherapy, an auxiliary method of immunotherapy. The bovine lactoferricin could be delivered to the tumor site by nanoparticles, be immediately released from nanoparticles in the acidic environment of lysosomes and the thermal condition caused by microwave radiation, and ultimately induce tumor apoptosis with the release of damage-associated molecular patterns (DAMPs). It is worth noting that the strategy of bovine lactoferricin-loaded nanoparticles intravenous injection combined with local microwave thermotherapy not only showed excellent efficacy in relieving tumor growth but also resulted in strong antitumor immunities, which was due to the released bovine lactoferricin under stimulating conditions, and the pool of tumor-associated antigens generated by tumor destruction. In conclusion, this work presents a strategy for tumor treatment based on dual-sensitive bovine lactoferricin-loaded nanoparticles combined with microwave thermotherapy, which may provide a solution for cationic anticancer peptides delivery and improving antitumor immune responses. ...
Alliance with EPR Effect: Combined Strategies to Improve the EPR Effect in the Tumor Microenvironment
Theranostics (IF 8.063) Pub Date : 2019-10-17 ,DOI:10.7150/thno.37198
Keywords: EPR effect, targeted therapy, nanoparticle, cancer treatment, drug delivery ...
Shape-Dependent, Chiro-optical Response of UV-Active, Nanohelix Metamaterials
Nano Letters (IF 12.279) Pub Date : 2019-10-03 ,DOI:10.1021/acs.nanolett.9b03274
Here, we systematically alter the morphology of titanium dioxide nanohelices, which make up the elements of the chiral metamaterials, to investigate how the nanoparticle shape affects chiro-optical activity across the UV spectrum. ...
Photothermal conversion triggered thermal asymmetric catalysis within metal nanoparticles loaded homochiral covalent organic framework
Nature Communications (IF 11.878) Pub Date : 2019-07-29 ,DOI:10.1038/s41467-019-11355-x
We report herein two metal nanoparticle (M NP)-loaded and porphyrin-containing homochiral covalent organic framework (CCOF)-based composite catalysts, and their application in the thermally-driven asymmetric one-pot Henry and A3-coupling reactions. ...
Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells
Nature Communications (IF 11.878) Pub Date : 2019-07-19 ,DOI:10.1038/s41467-019-11157-1
The fusion of immunologically interrelated two types of cells results in strong expression of the whole tumor antigen complexes and the immunological co-stimulatory molecules on cytomembranes (FMs), allowing the nanoparticle-supported FM (NP@FM) to function like antigen presenting cells (APCs) for T ...
Plasmonic photosynthesis of C 1 –C 3 hydrocarbons from carbon dioxide assisted by an ionic liquid
Nature Communications (IF 11.878) Pub Date : 2019-05-01 ,DOI:10.1038/s41467-019-10084-5
In this approach, plasmonic excitation of Au nanoparticles produces a charge-rich environment at the nanoparticle/solution interface conducive for CO2 activation, while an ionic liquid stabilizes charged intermediates formed at this interface, facilitating multi-step reduction and C–C coupling. ...
Miniature gold nanorods for photoacoustic molecular imaging in the second near-infrared optical window
Nature Nanotechnology (IF 33.407) Pub Date : 2019-03-04 ,DOI:10.1038/s41565-019-0392-3
These unexpected findings are confirmed using theoretical and numerical analysis, showing that photoacoustic signal is not only proportional to the optical absorption of the nanoparticle solution but also to the surface-to-volume ratio of the nanoparticles. ...
Single gold-bridged nanoprobes for identification of single point DNA mutations
Nature Communications (IF 11.878) Pub Date : 2019-02-19 ,DOI:10.1038/s41467-019-08769-y
Here we report a rapid method to identify point mutations by a single nanoparticle sensing system. DNA-directed gold crystallization forms rod-like nanoparticles with bridges based on structural design. ...
Ice-VII-like molecular structure of ambient water nanomeniscus
Nature Communications (IF 11.878) Pub Date : 2019-01-17 ,DOI:10.1038/s41467-019-08292-0
Surface-enhanced Raman spectroscopy on trace amounts of water, confined in inter-nanoparticle gaps, shows a narrowed tetrahedral peak at 3340 cm-1 in the OH-stretching band as well as a lattice-vibrational mode at 230 cm-1. ...
Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles
Nature Nanotechnology (IF 33.407) Pub Date : 2019-01-14 ,DOI:10.1038/s41565-018-0344-3
Although the total amount of plasma proteins adsorbed on nanoparticles does not determine C3 deposition efficiency, the biomolecule corona per se enhances immunoglobulin binding to all nanoparticle types. ...
Composition-Tunable Ultrasmall Manganese Ferrite Nanoparticles: Insights into their In Vivo T1 Contrast Efficacy
Theranostics (IF 8.063) Pub Date : 2019-02-28 ,DOI:10.7150/thno.31233
The development of a highly efficient, low-toxicity, ultrasmall ferrite nanoparticle-based T1 contrast agent for high-resolution magnetic resonance imaging (MRI) is highly desirable. ...
An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases
Nature Communications (IF 11.878) Pub Date : 2019-11-08 ,DOI:10.1038/s41467-019-13094-5
Whereas previous studies involved intratumoral injection, we report here an inhalable nanoparticle-immunotherapy system targeting pulmonary antigen presenting cells (APCs) to enhance anticancer immunity against lung metastases. ...
Optically oriented attachment of nanoscale metal-semiconductor heterostructures in organic solvents via photonic nanosoldering
Nature Communications (IF 11.878) Pub Date : 2019-10-30 ,DOI:10.1038/s41467-019-12827-w
As devices approach the single-nanoparticle scale, the rational assembly of nanomaterial heterojunctions remains a persistent challenge. While optical traps can manipulate objects in three dimensions, to date, nanoscale materials have been trapped primarily in aqueous solvents or vacuum. ...
Ultrabright gap-enhanced Raman tags for high-speed bioimaging
Nature Communications (IF 11.878) Pub Date : 2019-08-29 ,DOI:10.1038/s41467-019-11829-y
These GERTs reach a Raman enhancement factor beyond 5 × 109 and a detection sensitivity down to a single-nanoparticle level. ...
Assembling Ordered Crystals with Disperse Building Blocks
Nano Letters (IF 12.279) Pub Date : 2019-07-31 ,DOI:10.1021/acs.nanolett.9b02508
Nanoparticles covered in a polymer brush therefore may be predicted to be challenging building blocks in the formation of high-quality particle superlattices, as both the nanoparticle core and polymer brush are independent sources of dispersity in the system. ...
Nanopore blockade sensors for ultrasensitive detection of proteins in complex biological samples
Nature Communications (IF 11.878) Pub Date : 2019-05-08 ,DOI:10.1038/s41467-019-10147-7
Our ‘magnetic nanoparticle, nanopore blockade’ concept points towards a strategy to improving nanopore biosensors for quantitative analysis of various protein and nucleic acid species. ...
Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies
Nature Communications (IF 11.878) Pub Date : 2019-03-29 ,DOI:10.1038/s41467-019-09354-z
Here, we evaluate a unique prodrug/nanoparticle formation strategy to facilitate semi-solid prodrug nanoparticles (SSPNs) of the highly water-soluble nucleoside reverse transcriptase inhibitor (NRTI) emtricitabine (FTC), and injectable aqueous nanodispersions; in vitro to in vivo extrapolation (IVIVE ...
Harnessing liquid-in-liquid printing and micropatterned substrates to fabricate 3-dimensional all-liquid fluidic devices
Nature Communications (IF 11.878) Pub Date : 2019-03-06 ,DOI:10.1038/s41467-019-09042-y
Systems comprised of immiscible liquids held in non-equilibrium shapes by the interfacial assembly and jamming of nanoparticle−polymer surfactants have significant potential to advance catalysis, chemical separations, energy storage and conversion. ...
Chloroplast-selective gene delivery and expression in planta using chitosan-complexed single-walled carbon nanotube carriers
Nature Nanotechnology (IF 33.407) Pub Date : 2019-02-25 ,DOI:10.1038/s41565-019-0375-4
This nanoparticle-mediated chloroplast transgene delivery tool provides practical advantages over current delivery techniques as a potential transformation method for mature plants to benefit plant bioengineering and biological studies. ...
Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer
Nature Nanotechnology (IF 33.407) Pub Date : 2019-02-25 ,DOI:10.1038/s41565-019-0381-6
These results demonstrate the potential of the pH-responsive nanoparticle and the precise POLR2A targeted therapy in TNBC harbouring the common TP53 genomic alteration. ...
Engineered Mesenchymal Stem Cell/Nanomedicine Spheroid as an Active Drug Delivery Platform for Combinational Glioblastoma Therapy
Nano Letters (IF 12.279) Pub Date : 2019-02-21 ,DOI:10.1021/acs.nanolett.8b04697
Taken together, this system integrates the merits of cell- and nanoparticle- mediated drug delivery with the tumor-homing characteristics of MSC to advance targeted combinational cancer therapy. ...
Non defect-stabilized thermally stable single-atom catalyst
Nature Communications (IF 11.878) Pub Date : 2019-01-16 ,DOI:10.1038/s41467-018-08136-3
The resulting high concentrations of single atoms enable specific activities far exceeding those of conventional nanoparticle catalysts. ...
Author Correction: Sculpting nanoparticle dynamics for single-bacteria-level screening and direct binding-efficiency measurement
Nature Communications (IF 11.878) Pub Date : 2019-03-12 ,DOI:10.1038/s41467-019-09171-4
Author Correction ...
γ-Glutamyltranspeptidase-Triggered Intracellular Gadolinium Nanoparticle Formation Enhances the T2-Weighted MR Contrast of Tumor
Nano Letters (IF 12.279) Pub Date : 2019-03-25 ,DOI:10.1021/acs.nanolett.8b05154
Magnetic resonance imaging (MRI) is advantageous in the diagnosis of deep internal cancers, but contrast agents (CAs) are always needed to improve MRI sensitivity. Gadolinium (Gd)-based agents are routinely used as T1-dominated CAs in clinic but using intracellularly formed Gd nanoparticles to enhance the T2-weighted MRI of tumor in vivo at high magnetic field has not been reported. Herein, we rationally designed a “smart” Gd-based probe Glu-Cys(StBu)-Lys(DOTA-Gd)-CBT (1), which was subjected to γ-glutamyltranspeptidase (GGT) cleavage and an intracellular CBT-Cys condensation reaction to form Gd nanoparticles (i.e., 1-NPs) to enhance the T2-weighted MR contrast of tumor in vivo at 9.4 T. Living cell experiments indicated that the 1-treated HeLa cells had an r2 value of 27.8 mM–1 s–1 and an r2/r1 ratio of 10.6. MR imaging of HeLa tumor-bearing mice indicated that the T2 MR contrast of the tumor enhanced 28.6% at 2.5 h post intravenous injection of 1. We anticipate that our probe 1 could be employed for T2-weighted MRI diagnosis of GGT-related cancers in the future when high magnetic field is available in clinic. ...
An all-in-one homogeneous DNA walking nanomachine and its application for intracellular analysis of miRNA.
Theranostics (IF 8.063) Pub Date : 2019-09-20 ,DOI:10.7150/thno.36081
The target miRNA, cancer-related miR-21, can be captured by one of the tracks (track 1) and then walk to the other track (track 2), releasing the hybrid of track 1 and track 2 from the nanoparticle to produce a signal. ...
Transcytosis - An effective targeting strategy that is complementary to “EPR effect” for pancreatic cancer nano drug delivery
Theranostics (IF 8.063) Pub Date : 2019-10-17 ,DOI:10.7150/thno.38587
However, use of EPR effect as an across-the-board explanation for nanoparticle tumor access is likely over-simplified, particularly in the stroma rich solid tumors such as PDAC. ...
Disorder-to-Order Transition Mediated by Size Refocusing: A Route toward Monodisperse Intermetallic Nanoparticles
Nano Letters (IF 12.279) Pub Date : 2019-08-20 ,DOI:10.1021/acs.nanolett.9b02610
This demonstration advances the understanding of intermetallic nanoparticle formation in colloidal syntheses, which can expedite the development of electrocatalysts and magnetic storage materials. ...
On demand delivery and analysis of single molecules on a programmable nanopore-optofluidic device
Nature Communications (IF 11.878) Pub Date : 2019-08-16 ,DOI:10.1038/s41467-019-11723-7
Nanopore-based single nanoparticle detection has recently emerged as a vibrant research field with numerous high-impact applications. ...
Artificial Photosynthesis with Electron Acceptor/Photosensitizer-Aptamer Conjugates
Nano Letters (IF 12.279) Pub Date : 2019-08-15 ,DOI:10.1021/acs.nanolett.9b02880
The redox species generated by the photosensitizer-aptamer/electron acceptor supramolecular systems mediate the ferredoxin-NADP+ reductase, FNR, catalyzed synthesis of NADPH, and the Pt-nanoparticle-catalyzed evolution of hydrogen (H2). ...
Strong plasmon-molecule coupling at the nanoscale revealed by first-principles modeling
Nature Communications (IF 11.878) Pub Date : 2019-07-26 ,DOI:10.1038/s41467-019-11315-5
By considering a system comprising a few-hundred-atom aluminum nanoparticle interacting with benzene molecules, we show that cavity quantum electrodynamics holds down to resonators of a few cubic nanometers in size, yielding a single-molecule coupling strength exceeding 200 meV due to a massive vacuum ...
Precision Nanomedicine Development Based on Specific Opsonization of Human Cancer Patient-Personalized Protein Coronas
Nano Letters (IF 12.279) Pub Date : 2019-06-21 ,DOI:10.1021/acs.nanolett.9b01774
When a nanomedicine is administrated into the human body, biomolecules in biological fluids, particularly proteins, form a layer on the surface of the nanoparticle known as a “personalized protein corona”. ...
Biodistribution of gadolinium- and near infrared-labeled human umbilical cord mesenchymal stromal cell-derived exosomes in tumor bearing mice
Theranostics (IF 8.063) Pub Date : 2019-04-12 ,DOI:10.7150/thno.30030
Keywords: Extracellular vesicles, non-invasive imaging, ectopic osteosarcoma model, gadolinium nanoparticle. ...
Homotypic Cell Membrane-Cloaked Biomimetic Nanocarrier for the Targeted Chemotherapy of Hepatocellular Carcinoma.
Theranostics (IF 8.063) Pub Date : 2019-09-20 ,DOI:10.7150/thno.34837
Structurally, the homotypic HepG2 cell membrane was used as the cloak, and a poly (lactic-co-glycolic acid) (PLGA) nanoparticle as the core, resulting in the nanocarrier HepM-PLGA. Results: The HepM-PLGA nanoparticles exhibit excellent targeting ability toward HepG2 cells. ...
Electronic Structure-Dependent Surface Plasmon Resonance in Single Au–Fe Nanoalloys
Nano Letters (IF 12.279) Pub Date : 2019-08-06 ,DOI:10.1021/acs.nanolett.9b02396
Here, we investigate the localized surface plasmon resonance at the level of the single Au–Fe nanoparticle by applying a strategy that combines experimental measurements using near field electron energy loss spectroscopy with theoretical studies via a full wave numerical analysis and density functional ...
RNA-silencing nanoprobes for effective activation and dynamic imaging of neural stem cell differentiation
Theranostics (IF 8.063) Pub Date : 2019-07-09 ,DOI:10.7150/thno.35032
Keywords: gold nanoparticle, gene silencing, imaging, drug delivery, neural stem cell ...
Optimization and Design of Magnetic Ferrite Nanoparticles with Uniform Tumor Distribution for Highly Sensitive MRI/MPI Performance and Improved Magnetic Hyperthermia Therapy
Nano Letters (IF 12.279) Pub Date : 2019-05-13 ,DOI:10.1021/acs.nanolett.9b00630
First, by systematically elucidating the magnetic nanoparticle magnetic characteristics and the magnetic resonance imaging (MRI) and magnetic particle imaging (MPI) signal enhancement effects, which are based on the magnetic anisotropy, size, and type of nanoparticles, we found that 18 nm iron oxide ...
Atomically Resolved Anisotropic Electrochemical Shaping of Nano-electrocatalyst
Nano Letters (IF 12.279) Pub Date : 2019-05-02 ,DOI:10.1021/acs.nanolett.9b00918
Observing the detailed structure and morphology of the same nanoparticle at different stages of electrochemical treatment reveals new insights into atomic-scale processes such as size, faceting, strain and porosity development. ...
High Affinity to Skeleton Rare Earth Doped Nanoparticles for Near-Infrared II Imaging
Nano Letters (IF 12.279) Pub Date : 2019-04-17 ,DOI:10.1021/acs.nanolett.9b00140
This finding may open a window to increase efficient nanoparticle delivery in the fields such as immunotherapy and improve the diagnostic and therapeutic efficacy of cancer-targeted nanoparticles in clinical applications. ...
Tuning Chemical Interface Damping: Interfacial Electronic Effects of Adsorbate Molecules and Sharp Tips of Single Gold Bipyramids
Nano Letters (IF 12.279) Pub Date : 2019-03-13 ,DOI:10.1021/acs.nanolett.9b00338
Depending on the location (ortho, meta, and para) of the EDG, the effect of benzene rings with an EDG, which was considered to be induced by sulfur atoms bound to the nanoparticle surface, is weakened by the back transfer of electrons facilitated by the difference in the availability of the electrons ...
Evaluation of Polymer Nanoformulations in Hepatoma Therapy by Established Rodent Models
Theranostics (IF 8.063) Pub Date : 2019-02-20 ,DOI:10.7150/thno.31683
Keywords: hepatoma, rodent model, polymer nanoparticle, drug delivery, chemotherapy, molecular targeted therapy ...
Dendrimer-Functionalized Superparamagnetic Nanobeacons for Real-Time Detection and Depletion of HSP90α mRNA and MR Imaging.
Theranostics (IF 8.063) Pub Date : 2019-09-20 ,DOI:10.7150/thno.36545
Herein, we report that a cubic-shaped iron oxide nanoparticle (IONC) core nanobeacon is capable of delivering an HSP90α mRNA-specific molecular beacon (HSP90-MB) into living cells and enhancing T 2-weighted MR imaging in a tumor model. ...
Visualizing Spatial Variations of Plasmon–Exciton Polaritons at the Nanoscale Using Electron Microscopy
Nano Letters (IF 12.279) Pub Date : 2019-10-28 ,DOI:10.1021/acs.nanolett.9b03534
Here, we demonstrate that plexcitons generated by a hybrid system composed of an individual silver nanoparticle and a few-layer WS2 flake can be spectroscopically mapped with nanometer spatial resolution using electron energy loss spectroscopy in a scanning transmission electron microscope. ...
Active Surface Hydrophobicity Switching and Dynamic Interfacial Trapping of Microbial Cells by Metal Nanoparticles for Preconcentration and In-Plane Optical Detection
Nano Letters (IF 12.279) Pub Date : 2019-09-05 ,DOI:10.1021/acs.nanolett.9b03163
By employing real-time dark-field imaging, we directly observe that hydrophobic gold nanoparticle-coated E. coli, unlike its naked counterpart, is irreversibly trapped at the air/water interface because of elevated hydrophobicity. ...
Nanostructures, Faceting, and Splitting in Nanoliter to Yoctoliter Liquid Droplets
Nano Letters (IF 12.279) Pub Date : 2019-04-22 ,DOI:10.1021/acs.nanolett.9b00594
However, the elucidation of the mechanism driving these surprising effects, as well as their many potential applications, ranging from faceted nanoparticle synthesis through new industrial emulsification routes to controlled-release drug delivery within the human body, have been severely hampered by ...
Blood Circulation-Prolonging Peptides for Engineered Nanoparticles Identified via Phage Display
Nano Letters (IF 12.279) Pub Date : 2019-02-11 ,DOI:10.1021/acs.nanolett.8b04007
We hypothesized that peptides capable of increasing blood residence time for M13 bacteriophage, a rod-shaped nanoparticle self-assembled from proteins and nucleic acids, should also prolong blood circulation for engineered nanoparticles. ...
NaCeF4:Gd,Tb Scintillator as an X-ray Responsive Photosensitizer for Multimodal Imaging-Guided Synchronous Radio/Radiodynamic Therapy
Nano Letters (IF 12.279) Pub Date : 2019-10-08 ,DOI:10.1021/acs.nanolett.9b03682
Herein, the cerium (Ce)-doped NaCeF4:Gd,Tb scintillating nanoparticle (ScNP or scintillator) is first reported. Due to the sensitization effect of the Ce ions, Tb ions can emit fluorescence under X-ray irradiation to trigger X-ray excited fluorescence (XEF). ...
Tumor-Specific Silencing of Tissue Factor Suppresses Metastasis and Prevents Cancer-Associated Hypercoagulability
Nano Letters (IF 12.279) Pub Date : 2019-06-10 ,DOI:10.1021/acs.nanolett.9b01785
Herein, we reported a novel peptide-based nanoparticle that targets delivery and release of small interfering RNA (siRNA) into the tumor site to silence the expression of tumor-associated TF. ...
Peptide–Drug Conjugate-Based Nanocombination Actualizes Breast Cancer Treatment by Maytansinoid and Photothermia with the Assistance of Fluorescent and Photoacoustic Images
Nano Letters (IF 12.279) Pub Date : 2019-04-11 ,DOI:10.1021/acs.nanolett.9b00770
First, a type of organic–inorganic hybrid nanosystem (P@HCuS) was engineered by coupling the fluorescence-labeled amphiphilic fPEDC copolymer on the surface of hollow mesoporous copper sulfide nanoparticle (HCuS), in which HCuS was used as a photothermal and PA agent; fPEDC as a stabilizer, chromophore ...
On-demand PEGylation and dePEGylation of PLA-based nanocarriers via amphiphilic mPEG-TK-Ce6 for nanoenabled cancer chemotherapy.
Theranostics (IF 8.063) Pub Date : 2019-11-23 ,DOI:10.7150/thno.37128
Results: We demonstrated that the amphiphilic mPEG-TK-Ce6 can realize the PEGylation of Pt(IV) prodrug-loaded PLA nanoparticles and consequently enhanced nanoparticle accumulation in tumor tissues. ...
Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk–Shell Structure Augment Cancer Chemotherapy
Nano Letters (IF 12.279) Pub Date : 2019-11-05 ,DOI:10.1021/acs.nanolett.9b03817
Herein, a yolk–shell NP with a mesoporous silica nanoparticle (MSN)-supported PEGylated liposome yolk and CCM coating, CCM@LM, was developed for chemotherapy and exhibited a homologous tumor-targeting effect. ...
Proline Isomerization-Regulated Tumor Microenvironment-Adaptable Self-Assembly of Peptides for Enhanced Therapeutic Efficacy
Nano Letters (IF 12.279) Pub Date : 2019-10-15 ,DOI:10.1021/acs.nanolett.9b03136
In addition to the optimized cellular uptake, the morphological transition of TMAS into nanofibers in cytoplasm caused an enhanced intracellular ROS level compared to nanoparticle counterparts, thus leading to a lowered half lethal dose value for cancer cells. ...
Tip-Enhanced Raman Excitation Spectroscopy (TERES): Direct Spectral Characterization of the Gap-Mode Plasmon
Nano Letters (IF 12.279) Pub Date : 2019-09-18 ,DOI:10.1021/acs.nanolett.9b02925
While the coupled nanoparticle dimer model offers a correct qualitative description of gap-mode plasmon effects, it ignores the full spectrum of multipolar tip plasmon modes and their interaction with surface plasmon polariton (SPP) excitation in the substrate. ...
Ultrabright and Stable Luminescent Labels for Correlative Cathodoluminescence Electron Microscopy Bioimaging
Nano Letters (IF 12.279) Pub Date : 2019-08-14 ,DOI:10.1021/acs.nanolett.9b01819
We further illustrate how these nanocrystals can be readily differentiated from morphologically similar naturally occurring dense granules based on optical emission, making them attractive nanoparticle core materials for molecular labeling and (multi)color CCLEM. ...
Rapid Lipid-Based Approach for Normalization of Quantum-Dot-Detected Biomarker Expression on Extracellular Vesicles in Complex Biological Samples
Nano Letters (IF 12.279) Pub Date : 2019-07-25 ,DOI:10.1021/acs.nanolett.9b02232
We now describe a rapid nanoparticle- and dye-based fluorescent immunoassay that can distinguish among these possibilities by normalizing EV biomarker levels to EV abundance. ...
Surface Chemistry Enhancements for the Tunable Super-Liquid Repellency of Low-Surface-Tension Liquids
Nano Letters (IF 12.279) Pub Date : 2019-02-12 ,DOI:10.1021/acs.nanolett.8b04972
Step-wise tunable super-amphiphobic nanoparticle films with a Cassie–Baxter state (contact angle of >150° and sliding angle of <10°) against various liquids is demonstrated. This was tested down to very low surface tension liquids to a minimum of ca. 23.8 mN/m. ...
Tumor acidity activated triphenylphosphonium-based mitochondrial targeting nanocarriers for overcoming drug resistance of cancer therapy.
Theranostics (IF 8.063) Pub Date : 2019-10-30 ,DOI:10.7150/thno.35748
Methods: An acidity triggered cleavable polyanion PEI-DMMA (PD) was coated on the surface of positively charged lipid-polymer hybrid nanoparticle (DOX-PLGA/CPT) to form DOX-PLGA/CPT/PD via electrostatic interaction. ...
TRAIL acts synergistically with iron oxide nanocluster-mediated magneto- and photothermia.
Theranostics (IF 8.063) Pub Date : 2019-09-20 ,DOI:10.7150/thno.36320
Herein, to optimize its therapeutic use, TRAIL was grafted onto iron oxide nanoclusters (NCs) with the aim of increasing its pro-apoptotic potential through nanoparticle-mediated magnetic hyperthermia (MHT) or photothermia (PT). ...
Observation and Active Control of a Collective Polariton Mode and Polaritonic Band Gap in Few-Layer WS2 Strongly Coupled with Plasmonic Lattices
Nano Letters (IF 12.279) Pub Date : 2019-12-23 ,DOI:10.1021/acs.nanolett.9b05056
Here, in few-layered WS2 coupled with plasmonic nanoparticle lattices, we observe the formation of a collective polaritonic mode near the exciton energy and the formation of a complete polariton band gap with energy scale comparable to the exciton–plasmon coupling strength. ...
Biomineralization-inspired Crystallization of Manganese Oxide on Silk Fibroin Nanoparticles for in vivo MR/fluorescence Imaging-assisted Tri-modal Therapy of Cancer
Theranostics (IF 8.063) Pub Date : 2019-08-14 ,DOI:10.7150/thno.36252
Methods: As a proof-of-concept study, a multifunctional SF@MnO2 nanoparticle-based platform was strategically synthesized using SF as a reductant and a template via a biomineralization-inspired crystallization process in an extremely facile way. ...
Intelligent gold nanostars for in vivo CT imaging and catalase-enhanced synergistic photodynamic & photothermal tumor therapy
Theranostics (IF 8.063) Pub Date : 2019-07-13 ,DOI:10.7150/thno.33015
Finally, a phospholipid derivative with c(RGDyK) was used as the targeting moiety and the nanoparticle-encapsulating material. ...
Upconversion-Magnetic Carbon Sphere for Near Infrared Light-Triggered Bioimaging and Photothermal Therapy
Theranostics (IF 8.063) Pub Date : 2019-01-21 ,DOI:10.7150/thno.27952
Nanoparticle-based theranostics combines tumor imaging and cancer therapy in one platform, but the synthesis of theranostic agents is impeded by chemical groups on the surface and the size and morphology of the components. ...
Erratum: Powerful anti-colon cancer effect of modified nanoparticle-mediated IL-15 immunogene therapy through activation of the host immune system: Erratum.
Theranostics (IF 8.063) Pub Date : 2019-10-08 ,DOI:10.7150/thno.39082
[This corrects the article DOI: 10.7150/thno.24157.]. ...
Self-generating oxygen enhanced mitochondrion-targeted photodynamic therapy for tumor treatment with hypoxia scavenging
Theranostics (IF 8.063) Pub Date : 2019-09-20 ,DOI:10.7150/thno.36988
Methods: Herein, we report a photodynamic nanoparticle with sustainable hypoxia remission skills by both intratumoral H2O2 catalysis and targeted mitochondrial destruction. ...
A stage-specific cancer chemotherapy strategy through flexible combination of reduction-activated charge-conversional core-shell nanoparticles
Theranostics (IF 8.063) Pub Date : 2019-08-21 ,DOI:10.7150/thno.35057
Herein, we report a novel reduction-activated charge-conversional core-shell nanoparticle (CS NP) formula based on ring-closing metathesis of the thiamine disulfide system (TDS) to deliver the chemotherapeutic agent-gambogic acid (GA). ...
A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice
Theranostics (IF 8.063) Pub Date : 2019-08-14 ,DOI:10.7150/thno.36281
Keywords: PARP inhibitor, Talazoparib, Nanoparticle, BRCA-deficient breast cancer, immunomodulation ...
Molecular Engineering of Near-Infrared Light-Responsive BODIPY-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies for Cancer Theranostics
Theranostics (IF 8.063) Pub Date : 2019-07-09 ,DOI:10.7150/thno.34418
Background: Engineering a single organic-molecule-based nanoparticle integrating precise diagnosis and effective therapy is of great significance for cancer treatment and future clinical applications but remains a great challenge. ...
Supramolecular Nanomachines as Stimuli-Responsive Gatekeepers on Mesoporous Silica Nanoparticles for Antibiotic and Cancer Drug Delivery
Theranostics (IF 8.063) Pub Date : 2019-05-18 ,DOI:10.7150/thno.34576
This review will focus on mesoporous silica nanoparticle carriers with a large internal pore volume suitable for carrying anticancer and antibiotic drugs, and supramolecular components that function as caps that can both trap and release the drugs on-command. ...
Highly sensitive quantification of Alzheimer's disease biomarkers by aptamer-assisted amplification
Theranostics (IF 8.063) Pub Date : 2019-05-09 ,DOI:10.7150/thno.29232
Keywords: Alzheimer's disease, antibody-aptamer hybrid immunoassay, turn-on fluorophore, magnetic nanoparticle ...
Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy.
Theranostics (IF 8.063) Pub Date : 2019-08-15 ,DOI:10.7150/thno.35418
With advances in nanoparticle (NP) synthesis and engineering, nanoscale agents with both therapeutic and diagnostic functions have been increasingly exploited for cancer management. ...
Use of Porphysomes to detect primary tumour, lymph node metastases, intra-abdominal metastases and as a tool for image-guided lymphadenectomy: proof of concept in endometrial cancer
Theranostics (IF 8.063) Pub Date : 2019-04-13 ,DOI:10.7150/thno.31225
Keywords: Fluorescence guided surgery, Optical Imaging, Porphyrin nanoparticle, Porphysome, Endometrial Cancer ...
Strategy to enhance lung cancer treatment by five essential elements: inhalation delivery, nanotechnology, tumor-receptor targeting, chemo- and gene therapy.
Theranostics (IF 8.063) Pub Date : 2019-11-23 ,DOI:10.7150/thno.39816
Results: Proposed nanoparticle-based complex containing an anticancer drug, inhibitors of different types of EGFR-TKs and peptide targeted to the tumor-specific receptors (LHRH-NLC-siRNAs-TAX) demonstrated a favorable organ distribution and superior anticancer effect when compared with treatment by a ...
Employing Macrophage-Derived Microvesicle for Kidney-Targeted Delivery of Dexamethasone: An Efficient Therapeutic Strategy against Renal Inflammation and Fibrosis.
Theranostics (IF 8.063) Pub Date : 2019-08-02 ,DOI:10.7150/thno.33520
Nanoparticle tracking analysis, transmission electron microscopy, western blot and high-performance liquid chromatography were used to analyze the properties of MV-DEX. The LC-MS/MS was applied to investigate the protein compositions of MV-DEX. ...
Photosensitized H2 Evolution and NADPH Formation by Photosensitizer/Carbon Nitride Hybrid Nanoparticles
Nano Letters (IF 12.279) Pub Date : 2019-11-27 ,DOI:10.1021/acs.nanolett.9b04375
The photogenerated MV+• by the two hybrid photosystems is used to catalyze H2 evolution in the presence of Pt nanoparticle catalysts and to mediate the reduction of NADP+ to NADPH, in the presence of ferredoxin-NADP+ reductase, FNR. ...
Exosomes from M1-Polarized Macrophages Enhance Paclitaxel Antitumor Activity by Activating Macrophages-Mediated Inflammation
Theranostics (IF 8.063) Pub Date : 2019-02-28 ,DOI:10.7150/thno.30716
Methods: M1-Exos were isolated from M1-macrophages by ultracentrifugation and characterized by transmission electron, nanoparticle tracking analysis, dynamic light scattering and western blot. Then M1-Exos were used as Paclitaxel (PTX) carriers to prepare a nano-formulation (PTX- M1-Exos). ...
Erratum: Negative regulation of cationic nanoparticle-induced inflammatory toxicity through the increased production of prostaglandin E2 via mitochondrial DNA-activated Ly6C+ monocytes: Erratum.
Theranostics (IF 8.063) Pub Date : 2019-09-20 ,DOI:10.7150/thno.37524
[This corrects the article DOI: 10.7150/thno.21693.]. ...
A 25 micron-thin microscope for imaging upconverting nanoparticles with NIR-I and NIR-II illumination.
Theranostics (IF 8.063) Pub Date : 2019-11-23 ,DOI:10.7150/thno.37672
Methods: We have engineered INSITE (Immunotargeted Nanoparticle Single-Chip Imaging Technology), which integrates the unique optical properties of lanthanide-based alloyed upconverting nanoparticles (aUCNPs) with the time-resolved imaging of a 25-micron thin CMOS-based (complementary metal oxide semiconductor ...
Navigate-dock-activate anti-tumor strategy: Tumor micromilieu charge-switchable, hierarchically activated nanoplatform with ultrarapid tumor-tropic accumulation for trackable photothermal/chemotherapy.
Theranostics (IF 8.063) Pub Date : 2019-05-28 ,DOI:10.7150/thno.33280
The delivery of therapeutics into tumors remains a challenge in nanoparticle-mediated drug delivery. However, effective therapies such as photothermal therapy (PTT) are limited by quick systemic clearance and non-specific biodistribution. ...
Membrane Radiolabelling of Exosomes for Comparative Biodistribution Analysis in Immunocompetent and Immunodeficient Mice - A Novel and Universal Approach
Theranostics (IF 8.063) Pub Date : 2019-02-28 ,DOI:10.7150/thno.27891
B16F10-derived exosomes (ExoB16) were isolated using ultracentrfugation onto a single sucrose cushion, and were characterised for size, yield, purity, exosomal markers and morphology using NanoparticleTracking Analysis (NTA), protein measurements, flow cytometry and electron microscopy. ...



上一篇:2019年生物纳米研究最新热点报道(一)
下一篇:2019年生物纳米研究最新热点报道(三)
相关最新报道
疾病应用(检索)

Copyright©2020  Sunlipo Biotech Research Center for Nanomedicine(PubMed). All right reserved. 

 E-mail:sunlipotech@163.com(技术服务)info@med-nanotech.com(应用开发)

Tel:86-21-5127 9909    Fax:86-21-5193 6393

沪ICP备16052527号-1

沪公网安备 31011002001237号