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2019年生物纳米研究最新热点报道(三)
来源于:纳米医学网 | 作者: | 发布时间:2017-12-31 | 浏览:344


Hierarchical Nanoparticle Assemblies Formed via One-Step Catalytic Stamp Pattern Transfer
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-16 ,DOI:10.1021/acsami.8b19807
The hierarchical nanoparticle assemblies catalytically transferred onto the surface are not just nanoparticles but nanoparticle–polydimethylsiloxane residue composites. The in situ-synthesized nanoparticles retain optical properties. ...
Highly Sensitive Solvent-free Silver Nanoparticle Strain Sensors with Tunable Sensitivity Created Using an Aerodynamically Focused Nanoparticle Printer
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-15 ,DOI:10.1021/acsami.9b00943
We developed and presented highly sensitive solvent-free silver nanoparticle strain sensors fabricated using the aerodynamically focused nanoparticle (AFN) printer. The nanoparticles were printed in various conductive patterns. ...
Tribological Behavior of Grafted Nanoparticle on Polymer-Brushed Walls: A Dissipative Particle Dynamics Study
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-12 ,DOI:10.1021/acsami.8b19001
The grafted nanoparticle obviously acts as a nanobearing that partially replaces the sliding contact between two brushed walls with rolling contact between the grafted nanoparticle and two brushed walls and reduces the number of DPD particles withstanding high force. ...
Dual Targeted Synthetic Nanoparticle for Cardiovascular Diseases
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-30 ,DOI:10.1021/acsami.9b19036
Here, we report the design and synthesis of a dual targeted synthetic nanoparticle to perform double duty of diagnosis and therapy in atherosclerosis treatment regime. ...
A New Formyl Peptide Receptor-1 Antagonist Conjugated Fullerene Nanoparticle for Targeted Treatment of Degenerative Disc Diseases
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-08 ,DOI:10.1021/acsami.9b11783
In summary, we developed a novel targeted nanoparticle for treatment of lumbar radiculopathy by systemic delivery. This is a first-of-its-kind study for developing a novel class of targeted and systemic nanoparticle therapeutics to treat degenerative disc diseases. ...
Enhanced Efficacy of Temozolomide Loaded by a Tetrahedral Framework DNA Nanoparticle in the Therapy for Glioblastoma
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-21 ,DOI:10.1021/acsami.9b13829
Our nanoparticle, namely, tFNA-TMZ, shows a more obvious efficacy in killing TMZ-sensitive cells (A172 and U87) than single-agent TMZ. ...
Mapping of Pesticide Transmission on Biological Tissues by Surface Enhanced Raman Microscopy with a Gold Nanoparticle Mirror
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-12 ,DOI:10.1021/acsami.9b16084
The gold nanoparticle mirror was fabricated using 50 nm commercial citrate-capped gold nanoparticles upon the interface of water and a mediating solvent that was prepared using acetonitrile and hexane. ...
Nanoparticle-Assembled Thin Film with Amphipathic Nanopores for Organic Solvent Nanofiltration
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-02 ,DOI:10.1021/acsami.9b03753
Here, we report the fabrication of new films with nanoparticle-assembled structure via interfacial polymerization using quantum dots (QDs) as building blocks. The tailored QDs with hydrophobic and hydrophilic regions permit cross-linking into nanoparticle-assembled defect-free thin films. ...
Programming the Shape Transformation of a Composite Hydrogel Sheet via Erasable and Rewritable Nanoparticle Patterns
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-04 ,DOI:10.1021/acsami.9b16610
Numerous distinct and reversible shape transformations are achieved from a single hydrogel sheet by repeatably writing in the sheet with different nanoparticle patterns. The shape transformations were verified by finite element modeling. ...
Printing of Hydrophobic Materials in Fumed Silica Nanoparticle Suspension
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-05 ,DOI:10.1021/acsami.9b07433
The objective of this study is to propose a fumed silica nanoparticle-based yield-stress suspension as a hydrophobic support bath to enable 3D extrusion printing of various hydrophobic ink materials in a printing-then-solidification fashion. ...
Co-Delivery of Natural Compounds with a Dual-Targeted Nanoparticle Delivery System for Improving Synergistic Therapy in an Orthotopic Tumor Model
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-25 ,DOI:10.1021/acsami.9b06155
Overall, the dual-targeted nanoparticle system for the co-delivery of EGCG and CU greatly improved its synergistic effect in cancer therapy, indicating its great potential in developing treatments for prostate cancer therapy. ...
MoOx Nanoparticle Catalysts for d-Glucose Epimerization and Their Electrical Immobilization in a Continuous Flow Reactor
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-13 ,DOI:10.1021/acsami.9b13848
We report here the excellent activity of an MoOx nanoparticle (NP) catalyst for d-glucose epimerization to d-mannose and the electrical immobilization of NPs in a flow reaction. ...
Gold Nanoparticle Probe-Assisted Antigen-Counting Chip Using SEM
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-06 ,DOI:10.1021/acsami.8b19055
Herein, we propose a gold nanoparticle (GNP) probe-assisted sandwich-counting strategy that relies on a GNP probe, an antibody-functionalized chip to “count” antigen molecules using a scanning electron microscope. ...
Supramolecular Engineering of Molecular Inhibitors in an Adaptive Cytotoxic Nanoparticle for Synergistic Cancer Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-24 ,DOI:10.1021/acsami.9b20178
This small-sized nanoparticle accomplished the sequential release of both encapsulated drugs to exert antimetastatic, antivascular, and cytotoxic activities simultaneously. ...
Multipathway Antibacterial Mechanism of a Nanoparticle-Supported Artemisinin Promoted by Nitrogen Plasma Treatment
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-04 ,DOI:10.1021/acsami.9b15124
Herein, artemisinin crystal was first composited with silica nanoparticles (SNPs) to form an artemisinin@silica nanoparticle (A@SNP). ...
Tumor Homing Reactive Oxygen Species Nanoparticle for Enhanced Cancer Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-25 ,DOI:10.1021/acsami.9b07483
Herein, we report a tumor homing reactive oxygen species nanoparticle (THoR-NP) platform that is highly effective and selective for ablating malignant tumors. ...
Preparation and Properties of a Low Fouling Magnetic Nanoparticle and Its Application to the HPV Genotypes Assay in Whole Serum
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-07 ,DOI:10.1021/acsami.9b04147
Here, a novel nanoparticle made by the covalent attachment of polyethyleneimine and hyperbranched polyether polyol onto the gold shell surface of a magnetic bead demonstrated not only low fouling properties but also excellent stability in a variety of external environments, especially in complex biological ...
Preparation of Microgels with Ultrahigh Payload of Various Hydrophilic and Hydrophobic Inorganic Nanoparticle Composites up to 92 wt %
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-15 ,DOI:10.1021/acsami.8b20089
Microgel loading with inorganic nanoparticle (NP) composites attracts interest for various biomedical applications. ...
Construction of Bio/Nanointerfaces: Stable Gold Nanoparticle Bioconjugates in Complex Systems
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-16 ,DOI:10.1021/acsami.9b13659
Taken together, the features of Bio/Nanointerface make the nanoparticle suitable for various applications in harsh biological and environmental conditions due to the stability. This work may provide a universal modification method for obtaining stable nanoparticles. ...
Hyaluronate–Gold Nanoparticle/Glucose Oxidase Complex for Highly Sensitive Wireless Noninvasive Glucose Sensors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-24 ,DOI:10.1021/acsami.9b13874
Here, we developed a hyaluronate–gold nanoparticle/glucose oxidase (HA–AuNP/GOx) complex and an ultralow-power application-specific integrated circuit chip for noninvasive and robust wireless patch-type glucose sensors. ...
Quantum-Dot Tandem Solar Cells Based on a Solution-Processed Nanoparticle Intermediate Layer
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-30 ,DOI:10.1021/acsami.9b16164
In this work, a solution-processed ultrathin NiO and Ag nanoparticle film serves as an intermediate layer to enhance the charge recombination efficiency in PbS QD dual-junction tandem solar cells. ...
Lipid-mRNA Nanoparticle Designed to Enhance Intracellular Delivery Mediated by Shock Waves
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-06 ,DOI:10.1021/acsami.8b21398
We show that the thermodynamic state of the lipid membrane of the nanoparticle is a key design principle for acoustically responsive fusogenic nanoparticles. We have optimized a cationic LNP (designated LNPLH) with two different phase transitions near physiological conditions for delivering mRNA. ...
Thin Biobased Transparent UV-Blocking Coating Enabled by Nanoparticle Self-Assembly
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-27 ,DOI:10.1021/acsami.9b05383
Since HEC and HES share the same repeating glucose unit in the polymer backbone, it suggests that the conformational characteristics of the binder polymer have a strong influence on the nanoparticleaggregation, which plays a key role in determining the optical performance. ...
Siloxane-Encapsulated Upconversion Nanoparticle Hybrid Composite with Highly Stable Photoluminescence against Heat and Moisture
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-12 ,DOI:10.1021/acsami.8b20782
Herein, we report a siloxane-encapsulated upconversion nanoparticle hybrid composite (SE-UCNP), which exhibits excellent photoluminescence (PL) stability for over 40 days even at an elevated temperature, in high humidity, and in harsh chemicals. ...
Accelerated Bone Regeneration by Gold-Nanoparticle-Loaded Mesoporous Silica through Stimulating Immunomodulation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-28 ,DOI:10.1021/acsami.9b16848
In this study, we investigated the modulatory effects of gold nanoparticle (AuNP)-loaded mesoporous silica nanoparticles (Au-MSNs) on macrophages and the subsequent effects on the behavior of osteoblastic lineage cells. ...
Correction to “Sugar-Terminated Nanoparticle Chaperones Are 102–105 Times Better Than Molecular Sugars in Inhibiting Protein Aggregation and Reducing Amyloidogenic Cytotoxicity”
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-22 ,DOI:10.1021/acsami.9b14093
Colloidal solution of sugar-terminated nanoparticle under daylight (upper panel) and ultraviolet (UV) light (bottom panel). Figure 2c, d. Dynamic light scattering (DLS)-based hydrodynamic size (right panels) of (c) SNPmaltose and (d) SNPtrehalose. Figure 6a, b. ...
Assessment of Targeted Nanoparticle Assemblies for Atherosclerosis Imaging with Positron Emission Tomography and Potential for Clinical Translation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-19 ,DOI:10.1021/acsami.9b02750
Through conjugation of c-atrial natriuretic factor (CANF) peptide and radiolabeling with 64Cu, the 64Cu–CANF–comb nanoparticle was assessed for plaque imaging by targeting natriuretic peptide clearance receptor (NPRC) in a double-injury atherosclerosis model in rabbits. ...
Binary Thiol-Capped Gold Nanoparticle Monolayer Films for Quantitative Surface-Enhanced Raman Scattering Analysis
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-17 ,DOI:10.1021/acsami.9b02069
Here, we report the rational design and fabrication of a binary thiol-capped gold nanoparticle (AuNP) monolayer film (MLF) as a substrate for highly sensitive and quantitative SERS analysis. ...
TiO2 Nanoparticle-Enhanced Linker Recombinant Strand Displacement Amplification (LRSDA) for Universal Label-Free Visual Bioassays
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-06 ,DOI:10.1021/acsami.9b16314
Following the nick/extension cycles mediated by a bifunctional linker located at the 5′ end of the forward primers, the TiO2 nanoparticle-enhanced LRSDA process produces single-stranded products, constituting the G-quadruplex DNAzymes and catalyzing the chromogenic substrate to facilitate colorimetric ...
Engineering of Surface Environment of Pd Nanoparticle Catalysts on Carbon Support with Pyrene–Thiol Ligands for Semihydrogenation of Alkynes
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-04 ,DOI:10.1021/acsami.9b12470
A new type of pyrene–thiol derivative-modified Pd nanoparticle (NP) catalyst on a carbon black support for the efficient semihydrogenation of alkynes to alkenes is reported herein. ...
Role of Stabilizing Surfactants on Capacitance, Charge, and Ion Transport in Organic Nanoparticle-Based Electronic Devices
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-04 ,DOI:10.1021/acsami.8b19820
Surface adsorbates such as ionic surfactants or additives are often used to stabilize such nanoparticlesuspensions; however, little is presently known about the influence of such surfactants and additives on specific electronic and chemical functionality of nanoparticulate electronic devices. ...
Positron Emission Tomography/Magnetic Resonance Imaging of Glioblastoma Using a Functionalized Gadofullerene Nanoparticle
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-10 ,DOI:10.1021/acsami.9b03542
Most recently, an alanine-modified gadofullerene nanoparticle (Gd@C82-Ala) with excellent anticancer activity has been reported; however, the absolute tumor uptake of Gd@C82-Ala is still far from being satisfactory, and its dynamic pharmacokinetics and long-term metabolic behaviors remain to be elucidated ...
Tumor-Associated Fibroblast-Targeted Regulation and Deep Tumor Delivery of Chemotherapeutic Drugs with a Multifunctional Size-Switchable Nanoparticle
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-16 ,DOI:10.1021/acsami.9b13957
This paper reports a multifunctional size-switchable nanoparticle (denoted DGL (dendrigraft poly-l-lysine) (DGL)/GEM@PP/GA) for TAF-targeted regulation and deep tumor penetration. ...
Tuning ZnO Sensors Reactivity toward Volatile Organic Compounds via Ag Doping and Nanoparticle Functionalization
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-14 ,DOI:10.1021/acsami.9b07275
Typical samples that were investigated are Ag-doped and Ag nanoparticle-functionalized ZnO:Ag nanocolumnar films. ...
Stable, Flexible, and High-Performance SERS Chip Enabled by a Ternary Film-Packaged Plasmonic Nanoparticle Array
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-02 ,DOI:10.1021/acsami.9b09746
In this study, a rationally designed, ternary film-packaged, silver-coated gold-nanoparticle (Au@Ag NP) plasmonic array was fabricated and applied as a stable and high-performance SERS chip for highly sensitive sensing of thiabendazole (TBZ) residues in fruit juices. ...
Multifunctional Silver Nanoparticle Interlayer-Modified ZnO as the Electron-Injection Layer for Efficient Inverted Organic Light-Emitting Diodes
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-22 ,DOI:10.1021/acsami.8b21355
Here, a facile electron-injection architecture featuring a silver nanoparticle (AgNPs) interlayer-modified sol–gel-derived transparent zinc oxide (ZnO) ultrathin film is proposed and demonstrated. ...
Enhanced Anti-inflammatory Activity of Peptide–Gold Nanoparticle Hybrids upon Cigarette Smoke Extract Modification through TLR Inhibition and Autophagy Induction
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-26 ,DOI:10.1021/acsami.9b10536
Recently, we have developed a special class of peptide–gold nanoparticle hybrid system that can inhibit Toll-like receptor 4 (TLR4) signal transduction pathways and decrease its downstream inflammatory responses. ...
Preparation of a Ruthenium-Complex-Functionalized Two-Photon-Excited Red Fluorescence Silicon Nanoparticle Composite for Targeted Fluorescence Imaging and Photodynamic Therapy in Vitro
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-02 ,DOI:10.1021/acsami.9b00288
Here, we report a method for synthesizing a ruthenium-complex-functionalized two-photon-excited red fluorescence silicon nanoparticle composite (SiNPs–Ru) based on fluorescence resonance energy transfer under mild experimental conditions. ...
Multifunctional Molecular Beacons-Modified Gold Nanoparticle as a Nanocarrier for Synergistic Inhibition and in Situ Imaging of Drug-Resistant-Related mRNAs in Living Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-17 ,DOI:10.1021/acsami.9b11340
Herein, multifunctional molecular beacons (MBs)-modified gold nanoparticle (AuNP) as a nanocarrier (MBs-AuNP) is developed for synergistic inhibition and in situ imaging of drug-resistant-related mRNAs in living cells. ...
Mixed Mucoadhesive Amphiphilic Polymeric Nanoparticles Cross a Model of Nasal Septum Epithelium in Vitro
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-10 ,DOI:10.1021/acsami.9b04766
Finally, we assessed the nanoparticle permeability across liquid–liquid and air–liquid monolayers of a nasal septum epithelial cell line and studied the effect of nanoparticle concentration and temperature on the apparent permeability. ...
Multifunctional Nanobiohybrid Material Composed of Ag@Bi2Se3/RNA Three-Way Junction/miRNA/Retinoic Acid for Neuroblastoma Differentiation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-15 ,DOI:10.1021/acsami.8b16925
Here, the topological insulator bismuth selenide nanoparticle (Bi2Se3 NP) was core-shelled with silver (Ag@Bi2Se3) to represent remarkable biocompatibility and plasmonic features (ca. 2.3 times higher than those of Ag nanoparticle). ...
Microstructural Evolution of Au@Pt Core–Shell Nanoparticles under Electrochemical Polarization
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-13 ,DOI:10.1021/acsami.9b10158
In contrast, AuPt alloys undergo surface dealloying and significant leaching of Pt out of the nanoparticle. ...
Controlled Grafting of Colloidal Nanoparticles on Graphene through Tailored Electrostatic Interaction
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-18 ,DOI:10.1021/acsami.9b01519
Nanoparticle/graphene hybrid composites have been of great interest in various disciplines due to their unique synergistic physicochemical properties. ...
A CD44-Targeting Programmable Drug Delivery System for Enhancing and Sensitizing Chemotherapy to Drug-Resistant Cancer
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-30 ,DOI:10.1021/acsami.8b19798
The nanoparticle was composed of a cross-linked CS hydrogel shell and hydrophobic cores containing both free drugs and CS-linked prodrugs. Interestingly, the nanoparticle could mediate tumor-specific CD44 targeting. ...
Revealing Lectin–Sugar Interactions with a Single Au@Ag Nanocube
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-21 ,DOI:10.1021/acsami.9b15349
We expect that this nanobiosensor system can provide an alternative important method for monitoring the specific binding of lectin–sugar at a single nanoparticle surface. ...
Feasibility Study of Single-Crystal Si Island Manufacturing by Microscale Printing of Nanoparticles and Laser Crystallization
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-05 ,DOI:10.1021/acsami.9b09577
Currently, the printed films are dominant in amorphous, polycrystalline, or nanoparticle films. In this article, manufacturing of single-crystal silicon micro/nano-islands is attempted. ...
Continuous Flow Methods of Fabricating Catalytically Active Metal Nanoparticles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-22 ,DOI:10.1021/acsami.9b07268
Translation of batch-scale solution nanoparticle syntheses to continuous flow reactors has been identified as one method to address the scaling issue. ...
Chiral Selectivity of Porphyrin–ZnO Nanoparticle Conjugates
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-15 ,DOI:10.1021/acsami.8b22749
Recognition of enantiomers is one of the most arduous challenges in chemical sensor development. Although several chiral systems exist, their effective exploitation as the sensitive layer in chemical sensors is hampered by several practical implications that hinder stereoselective recognition in solid state. In this paper, we report a new methodology to efficiently prepare chiral solid films, by using a hybrid material approach where chiral porphyrin derivatives are grafted onto zinc oxide nanoparticles. Circular dichroism (CD) evidences that the solid-state film of the material retains supramolecular chirality due to porphyrin interactions, besides an additional CD feature in correspondence of the absorbance of ZnO (375 nm), suggesting the induction of chirality in the underlying zinc oxide nanoparticles. The capability of hybrid material to detect and recognize vapors of enantiomer pairs was evaluated by fabricating gas sensors based on quartz microbalances. Chiral films of porphyrin on its own were used for comparison. The sensor based on functionalized nanostructures presented a remarkable stereoselectivity in the recognition of limonene enantiomers, whose ability to intercalate in the porphyrin layers makes this terpene an optimal chiral probe. The chiroptical and stereoselective properties of the hybrid material confirm that the use of porphyrin-capped ZnO nanostructures is a viable route for the formation of chiral selective surfaces. ...
Particle Consolidation and Electron Transport in Anatase TiO2 Nanocrystal Films
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-17 ,DOI:10.1021/acsami.9b12693
Thermal annealing of the immobilized films at 100 °C < T < 450 °C in air was performed to generate particle–particle contacts upon virtual preservation of the structural properties of the nanoparticle films. ...
Gas Phase Electrodeposition Enabling the Programmable Three-Dimensional Growth of a Multimodal Room Temperature Nanobridge Gas Sensor Array
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-29 ,DOI:10.1021/acsami.9b12545
The programmable multimaterial gas phase nanoparticle electrodeposition concept enables the fabrication of a 3D multimodal conductometric gas sensor array. ...
Reversible Self-Healing for Preserving Optical Transparency and Repairing Mechanical Damage in Composites
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-19 ,DOI:10.1021/acsami.9b00967
This research concentrates on the healing of optical properties, roughness, contact angle hysteresis, and shallow scratches in polymer/nanoparticle composites. ...
Microfluidic-Based Immunomodulation of Immune Cells Using Upconversion Nanoparticles in Simulated Blood Vessel–Tumor System
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-03 ,DOI:10.1021/acsami.9b15178
Here, we developed folic acid and secondary lymphoid tissue chemokine-loaded mesoporous silica-modified upconversion nanoparticle construct as a targeting, delivery, and imaging system to attract immune cells to folate receptor-expressing tumor cells. ...
A Hybrid Electrocatalyst with a Coordinatively Unsaturated Metal–Organic Framework Shell and Hollow Ni3S2/NiS Core for Oxygen Evolution Reaction Applications
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-24 ,DOI:10.1021/acsami.9b04479
Herein, we report a heterogeneous nanostructure of a Ni-based MOF-modified Ni3S2/NiS hollow nanoparticle. ...
Near-Infrared Fluorescent Endoscopic Image-Guided Photothermal Ablation Therapy of Colorectal Cancer Using Dual-Modal Gold Nanorods Targeting Tumor-Infiltrating Innate Immune Cells in a Transgenic TS4 CRE/APCloxΔ468 Mouse Model
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-04 ,DOI:10.1021/acsami.9b04186
CRC is a good candidate for nanoparticle-mediated photothermal ablation (PTA) therapy. Herein, we developed a near-infrared fluorescent (NIRF) endoscopic image-guided PTA approach using a nanoparticle capable of simultaneously diagnosing and treating CRC. ...
Fabrication and characterization of layer-by-layer composite nanoparticles based on zein and hyaluronic acid for co-delivery of curcumin and quercetagetin
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-15 ,DOI:10.1021/acsami.9b02529
In particular, they changed from coated nanoparticles to nanoparticle-filled microgels as the level of HA increased. ...
PEGylation-Dependent Metabolic Rewiring of Macrophages with Silk Fibroin Nanoparticles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-12 ,DOI:10.1021/acsami.8b18716
The macrophages internalized both types of nanoparticles, but they showed different phenotypic and metabolic responses to each nanoparticle type. ...
Cooperative Bilayer of Lattice-Disordered Nanoparticles as Room-Temperature Sinterable Nanoarchitecture for Device Integrations
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-16 ,DOI:10.1021/acsami.9b00307
This nanoarchitecture features a loose nanoparticle layer with unprecedented deformability for interfacial gap-filling, and a compact one providing firm bonding with the component surface. The two distinct nanoparticle layers cooperatively enhance the interconnecting performance by 73–357%. ...
Zoledronic Acid-containing Nanoparticles With Minimum Premature Release Show Enhanced Activity Against Extraskeletal Tumor
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-11 ,DOI:10.1021/acsami.8b16588
However, many previously reported bisphosphonate nanoparticle formulations show extensive premature release of bisphosphonates. ...
Universal Nanoparticle Wetting Agent for Upscaling Perovskite Solar Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-21 ,DOI:10.1021/acsami.8b22206
Solution-processed perovskite solar cells reach efficiencies over 23% on lab-scale. However, a reproducible transfer of these established processes to upscaling techniques or different substrate surfaces requires a highly controllable perovskite film formation. Especially, hydrophobic surfaces cause severe dewetting issues. Such surfaces are particularly crucial for the so-called standard n–i–p cell architecture when fullerene-based electron transport layers are employed underneath perovskite absorber films. In this work, a unique and universally applicable method was developed based on the deposition of size-controlled Al2O3 or SiO2 nanoparticles. By enhancing the surface energy, they act as a universal wetting agent. This allows perovskite precursor solutions to be spread perfectly over various substrates including problematic hydrophobic Si-wafers or fullerene self-assembled monolayers (C60-SAMs). Moreover, the results show that the perovskite morphology, solar cell performance, and reproducibility benefit from the presence of the nanoparticles at the interface. When applied to 144 cm2 C60-SAM-coated substrates, homogenous coverage can be realized via spin coating resulting in average efficiencies of 16% (maximum 18%) on individualized cells with 0.1 cm2 active area. Modules in the same setup reached maximum efficiencies of 11 and 7% on 2.8 and 23.65 cm2 aperture areas, respectively. ...
Cell Membrane-Coated Porphyrin Metal–Organic Frameworks for Cancer Cell Targeting and O2-Evolving Photodynamic Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-15 ,DOI:10.1021/acsami.9b14084
In this work, we introduce a novel O2-evolving PDT nanoparticle for homologous cancer cell targeting as well as dual-mode imaging [i.e., magnetic resonance imaging (MRI) and fluorescence imaging]. ...
Binary Self-Assembly of Conjugated Block Copolymers and Quantum Dots at the Air–Liquid Interface into Ordered Functional Nanoarrays
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-25 ,DOI:10.1021/acsami.9b08892
Controlling the nanoscale morphology of conducting polymer/nanoparticle hybrid films is a highly desired but challenging task. ...
Preparation of Graphene Aerogel with High Mechanical Stability and Microwave Absorption Ability via Combining Surface Support of Metallic-CNTs and Interfacial Cross-Linking by Magnetic Nanoparticles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-28 ,DOI:10.1021/acsami.8b22382
Here, a novel method to prepare graphene aerogel with high mechanical stability was proposed via combining surface support brought by metallic-CNT networks and interfacial cross-linking of GO sheets achieved by nanoparticle selective absorption. ...
Critical Features for Mesoporous Silica Nanoparticles Encapsulated into Erythrocytes
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-24 ,DOI:10.1021/acsami.8b18434
In addition to PEGylation, we further introduce positively charged functional groups onto the MSNs to show that nanoparticle-encapsulated hRBCs could serve as depots for delivering biological molecules through electrostatic attraction or chemical conjugation with MSNs. ...
Gold Nanoparticle Transforms Activated Cancer-Associated Fibroblasts to Quiescence
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-11 ,DOI:10.1021/acsami.9b03313
Activated cancer-associated fibroblasts (CAFs) play a major role in the poor outcome in many diseases including pancreatic cancer. Normally quiescent with high lipid content and low proliferative capacity, CAFs receiving cues from cancer cells in the tumor microenvironment become activated and transformed into a lipid-deprived and highly proliferative myofibroblast type phenotype. Therefore, reversal of activated fibroblasts to the quiescence state is an important area of investigation that may help the therapeutic management of a number of diseases including pancreatic cancer. Here, we describe a unique biological function of gold nanoparticles (GNPs) and demonstrate that GNPs may be used to transform activated CAFs to quiescence and provide insights into the underlying molecular mechanisms. Using immortalized and primary patient derived CAFs, we demonstrate that GNPs enhanced lipid content in the cells by inducing expression of lipogenesis genes such as FASN, SREBP2, and FABP3. Using pharmacological inhibitors of lipolysis, lipophagy, and fatty acid oxidation, we further demonstrate that CAFs utilized a GNP-induced endogenously synthesized lipid to maintain the quiescent phenotype. Consequently, treatment with GNP sensitizes CAF to FASN inhibitor or FASN siRNA. Hence, GNPs may be used as a tool to probe mechanisms of quiescence in CAFs and help device strategies to target the stromal compartment exploiting the mechanisms of lipid utilization. ...
CDs@ZIF-8 Modified Thin Film Polyamide Nanocomposite Membrane for Simultaneous Enhancement of Chlorine-Resistance and Disinfection Byproducts Removal in Drinking Water
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-30 ,DOI:10.1021/acsami.9b11006
The large surface area and abundant oxygen-containing groups of CDs@ZIF-8 made the nanoparticle act as a nanocarbon filler with high adsorption capacity of DBPs. ...
Inkjet Printing of Reactive Silver Ink on Textiles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-29 ,DOI:10.1021/acsami.8b18231
Nanoparticle-based conductive inks frequently cause blockage/clogging of inkjet printer nozzles, making it a less than ideal method for applying these functional materials. ...
Porous N-Doped Carbon-Encapsulated CoNi Alloy Nanoparticles Derived from MOFs as Efficient Bifunctional Oxygen Electrocatalysts
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-03 ,DOI:10.1021/acsami.8b13290
A porous N-doped carbon-encapsulated CoNi alloy nanoparticle composite (CoNi@N–C) was prepared using a bimetallic metal–organic framework composite as the precursor. ...
Gold Nanoparticle-Functionalized Reverse Thermal Gel for Tissue Engineering Applications
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-07 ,DOI:10.1021/acsami.9b00666
Utilizing polymers in cardiac tissue engineering holds promise for restoring function to the heart following myocardial infarction, which is associated with grave morbidity and mortality. To properly mimic native cardiac tissue, materials must not only support cardiac cell growth but also have inherent conductive properties. Here, we present an injectable reverse thermal gel (RTG)-based cardiac cell scaffold system that is both biocompatible and conductive. Following the synthesis of a highly functionalizable, biomimetic RTG backbone, gold nanoparticles (AuNPs) were chemically conjugated to the backbone to enhance the system’s conductivity. The resulting RTG–AuNP hydrogel supported targeted survival of neonatal rat ventricular myocytes (NRVMs) for up to 21 days when cocultured with cardiac fibroblasts, leading to an increase in connexin 43 (Cx43) relative to control cultures (NRVMs cultured on traditional gelatin-coated dishes and RTG hydrogel without AuNPs). This biomimetic and conductive RTG–AuNP hydrogel holds promise for future cardiac tissue engineering applications. ...
Design and Application of Cisplatin-Loaded Magnetic Nanoparticle Clusters for Smart Chemotherapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-07 ,DOI:10.1021/acsami.8b18717
One of the major challenges of drug delivery is the development of suitable carriers for therapeutic molecules. In this work, a novel nanoformulation based on superparamagnetic nanoclusters [magnetic nanocrystal clusters (MNCs)] is presented. In order to control the size of the nanoclusters and the density of magnetic cores, several parameters were evaluated and tuned. Then, MNCs were functionalized with a polydopamine layer (MNC@PDO) to improve their stability in aqueous solution, to increase density of functional groups and to obtain a nanosystem suitable for drug-controlled release. Finally, cisplatin was grafted on the surface of MNC@PDO to exploit the system as a magnetic field-guided anticancer delivery system. The biocompatibility of MNC@PDO and the cytotoxic effects of MNC@PDO–cisplatin complex were determined against human cervical cancer (HeLa) and human breast adenocarcinoma (MCF-7) cells. In vitro studies demonstrated that the MNC@PDO–cisplatin complexes inhibited the cellular proliferation by a dose-dependent effect. Therefore, by applying an external magnetic field, the released drug exerted its effect on a specific target area. In summary, the MNC@PDO nanosystem has a great potential to be used in targeted nanomedicine for the delivery of other drugs or biofunctional molecules. ...
Arbitrary Gold Nanoparticle Arrays Fabricated through AFM Nanoxerography and Interfacial Seeded Growth
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-04 ,DOI:10.1021/acsami.9b13899
Based on arrays of Au seeds fabricated with atomic force microscopy (AFM) nanoxerography, the seeded growth of gold nanoparticles (Au NPs) on surface is achieved. The size evolution of Au NPs in each spot is tracked by in situ AFM and SEM images because each spot can be easily localized in the array system. The extinction microspectra extracted in real time with enhanced signals and red-shift can further monitor the increasing size of Au NPs. As a powerful platform, AFM nanoxerography makes it easy to tune the spot size and the intervals among spots in the Au NP arrays without preparing a template. It also allows for fabricating arbitrary patterns including various symbols and graphs. More interestingly, the in situ growth of Au NPs offers an approach to decreasing the interparticle distance, and thus forming closely interconnected Au nanowire assembly, exhibiting immense potential in the nanoelectronic system. ...
Protein-Induced Gold Nanoparticle Assembly for Improving the Photothermal Effect in Cancer Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-14 ,DOI:10.1021/acsami.8b21488
Gold nanoparticles (AuNPs) are promising photothermal agents for cancer therapy. However, the absorption of spherical AuNPs is weak in the desired tissue-penetrating near-infrared (NIR) window, resulting in low photothermal efficiency within this window. Here, we show that fibrous nanostructures assembled from spherical AuNPs since the templating effect of silk fibroin (SF) could red-shift the optical absorption to NIR and thus present improved photothermal efficiency within the NIR window. Specifically, negatively charged SF, a protein derived from Bombyx mori, was assembled into nanofibers due to the interaction with the positively charged AuNPs and concomitantly templated the AuNPs into fibrous nanostructures. The resultant AuNPs/SF nanofibers presented higher NIR light absorption at 808 nm and higher photothermal efficiency under 808 nm NIR irradiation than nonassembled AuNPs. In vitro and in vivo analyses proved that AuNPs/SF nanofibers could efficiently kill breast cancer cells and destruct breast cancer tumor tissues under one-time NIR irradiation for 6 min by photothermal therapy (PTT) but nonassembled AuNPs could not. This work suggests that the self-assembled AuNPs/SF nanofibers are effective photosensitizers for PTT, and biotemplated assembly of photothermal agents into highly ordered nanostructures is a promising approach to increasing the PTT efficiency. ...
Nanoscale Characterization of Ion Mobility by Temperature-Controlled Li-Nanoparticle Growth
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-22 ,DOI:10.1021/acsami.8b16281
Detailed understanding of electrochemical transport processes on the nanoscale is considered not only as a topic of fundamental scientific interest but also as a key to optimize material systems for application in electrochemical energy storage. A prominent example is solid-state electrolytes, where transport properties are strongly influenced by the microscopic structure of grain boundaries or interface regimes. However, direct characterization of ionic transport processes on the nanoscale remains a challenge. For a heterogeneous Li+-conducting glass ceramic, we demonstrate quantitative nanoscopic probing of electrochemical properties on the basis of temperature-controlled growth of nanoscopic Li particles with conductive tip atomic force microscopy. The characteristic energy barriers can be derived from the particle growth dynamics and are consistent with simultaneously recorded nanovoltammetry, which can be interpreted as an interplay between overpotentials, ion conductivity, and nanoscale spreading resistance. In the low-temperature limit at around 170 K, where the particle growth speed is slowed down by several orders of magnitude with respect to room temperature, we demonstrate ion-conductivity mapping with lateral resolutions only limited by the effective tip-surface contact radius. Our mapping measurements reveal the insulating character of the AlPO4 phase, whereas any influence of grain boundaries is related to subsurface constrictions of the current paths. ...
3D Printing Enabled Customization of Functional Microgels
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-25 ,DOI:10.1021/acsami.8b18701
By mixing nanoparticle-encapsulated drugs into the monomer solution, the microgels with sustained drug release can be readily prepared. Also, cells can be printed into microgels with survival and proliferation. ...
Photosensing System Using Photosystem I and Gold Nanoparticle on Graphene Field-Effect Transistor
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-31 ,DOI:10.1021/acsami.9b14771
In this study, a light sensor is fabricated based on photosystem I (PSI) and a graphene field-effect transistor (FET) that detects light at a high quantum yield under ambient conditions. We immobilized PSI on a micrometer-sized graphene FET using Au nanoparticles (AuNPs) and measured the I–V characteristics of the modified graphene FET before and after light irradiation. The source–drain current (Isd) increased upon illumination, exhibiting a photoresponsivity of 4.8 × 102 A W–1, and the charge neutrality point of graphene shifted by −12 mV. This system represents the first successful photosensing system based on proteins and a solution-gated graphene FET. The probable mechanism of this negative shift can be explained by the increase in negative charge carriers in graphene induced by a hole trap in the AuNP resulting from electron transfer from the AuNP to PSI. Photoresponses were only observed in the presence of two surface-active agents, n-hexyltrimethylammonium bromide and sodium dodecylbenzenesulfonate, because they caused the formation of a hydrophobic environment on the surface of the graphene. The lipid layer of these agents caused dissociation of ascorbate ions from the graphene sheet, thereby expanding the Debye screening length of the electrolyte solution. The hydrophobic environment above graphene also enhanced hole storage in the AuNP through electron transfer from the AuNP to PSI. ...
Lithiophilic Ag Nanoparticle Layer on Cu Current Collector toward Stable Li Metal Anode
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-14 ,DOI:10.1021/acsami.9b01521
Intractable hurdles of low Coulombic efficiency and dendritic Li formation during a repeated deposition/stripping process hinder the commercial use of Li metal anode for next-generation battery systems. Achieving uniform Li nucleation is one of the effective strategies to address these issues, and it is of practical importance to realize this on a commercial Cu current collector that is lithiophobic. Herein, we design a nanostructured Ag lithiophilic layer on a Cu foil via an electroless plating process for a Li metal current collector. The deposition of lithiophilic Ag particles that are homogeneously distributed on the Cu foil can reduce the nucleation overpotential, realizing uniform Li nucleation and subsequently flat Li plating. As a result, a stable cycle stability of up to 360 h (1 mA cm–2) and an average Columbic efficiency of 94.5% for 100 cycles (1 mA cm–2) are achieved. Furthermore, CuAg full cells with LiFePO4 as a cathode exhibit good cycle performances and low polarization voltage. This approach provides another facile way for a stable lithium metal anode. ...
In Situ Biomineralization of CuxZnySnzS4 Nanocrystals within TiO2-Based Quantum Dot Sensitized Solar Cell Anodes
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-26 ,DOI:10.1021/acsami.9b15545
Nanoparticle synthesis occurs in a minimal buffered solution containing only the enzyme, metal chloride and acetate salts, and l-cysteine as a capping agent and sulfur source. ...
Facile Strategy for Visible Disassembly of Spherical Nucleic Acids Programmed by Catalytic DNA Circuits
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-24 ,DOI:10.1021/acsami.9b02107
This strategy will have great potential in the fabrication of a portable low-cost DNA diagnostic kit, and it is also a very promising method to be used in other applications, such as complex DNA networks and programmable phase transformation of nanoparticle superlattices. ...
Albumin-Modified Cationic Nanocarriers To Potentially Create a New Platform for Drug Delivery Systems
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-29 ,DOI:10.1021/acsami.9b05599
Cationic nanocarriers have emerged as promising nanoparticle systems for the effective delivery of nucleic acid and anticancer drugs to cancer cells. ...
Reducible Branched Ester-Amine Quadpolymers (rBEAQs) Codelivering Plasmid DNA and RNA Oligonucleotides Enable CRISPR/Cas9 Genome Editing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-08 ,DOI:10.1021/acsami.8b20206
Functional codelivery of plasmid DNA and RNA oligonucleotides in the same nanoparticle system is challenging due to differences in their physical properties as well as their intracellular locations of function. ...
Electrochemical Biosensor for DNA Methylation Detection through Hybridization Chain-Amplified Reaction Coupled with a Tetrahedral DNA Nanostructure
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-22 ,DOI:10.1021/acsami.8b20144
The platform consisted of stem–loop–tetrahedron composite DNA probes anchoring at a Au nanoparticle-coated gold electrode, a restriction enzyme digestion of HpaII, and signal amplification procedures including electrodeposition of Au nanoparticles, hybridization chain reaction, and horseradish peroxidase ...
Biocompatible Injectable Magnetic Hydrogel Formed by Dynamic Coordination Network
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-26 ,DOI:10.1021/acsami.9b17627
., HA–BP) polymeric solution and iron oxide (Fe3O4) nanoparticle dispersion, in which the hydrogel networks are cross-linked by BP groups and iron atoms on the surface of particle. ...
Engineering pH-Responsive BODIPY Nanoparticles for Tumor Selective Multimodal Imaging and Phototherapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-13 ,DOI:10.1021/acsami.9b16403
The BDP nanoparticle formulations possessed multifunctional biological features, including selective treatment of cancer cells, near-infrared fluorescence, photoacoustic and computed tomography imaging, and photodynamic and photothermal therapy, as validated by cellular and animal experiments. ...
Electroassembly of Chitin Nanoparticles to Construct Freestanding Hydrogels and High Porous Aerogels for Wound Healing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-12 ,DOI:10.1021/acsami.9b13063
The electroassembly is a simple, straightforward, and controllable process, which crucially depends on the pH of the chitin nanoparticle suspension and the degree of deacetylation of chitin. ...
Simultaneous Inverse Design of Materials and Structures via Deep Learning: Demonstration of Dipole Resonance Engineering Using Core–Shell Nanoparticles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-26 ,DOI:10.1021/acsami.9b05857
A neural network to learn the correlation between the extinction spectra of electric and magnetic dipoles and core–shell nanoparticle designs, which include material information and shell thicknesses, is developed and trained. ...
Enhanced Stability and Controlled Delivery of MOF-Encapsulated Vaccines and Their Immunogenic Response In Vivo
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-01 ,DOI:10.1021/acsami.8b20504
The immunoassay and spectroscopy analysis together demonstrate enhanced thermal and chemical stability to the conformational structure of the encapsulated viral nanoparticle. ...
Remote Induction of Cell Autophagy by 2D MoS2 Nanosheets via Perturbing Cell Surface Receptors and mTOR Pathway from Outside of Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-11 ,DOI:10.1021/acsami.8b21886
Our findings prove that the perturbation of cellular function without nanoparticle internalization has significant nanomedicinal and nanotoxicological significances. ...
Biocompatible Heat-Shock Protein Inhibitor-Delivered Flowerlike Short-Wave Infrared Nanoprobe for Mild Temperature-Driven Highly Efficient Tumor Ablation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-06 ,DOI:10.1021/acsami.8b21483
Herein, a flowerlike NiS2-coated NaLuF4:Nd (Lu:Nd@NiS2) nanoparticle was synthesized as a novel therapeutic agent for short-wave infrared light imaging and magnetic resonance imaging to guide photothermal therapy (PTT). ...
Interfacial Nanoparticle Complexation of Oppositely Charged Nanocelluloses into Functional Filaments with Conductive, Drug Release, or Antimicrobial Property
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-20 ,DOI:10.1021/acsami.9b15555
Construction of colloidal nanoparticles (NPs) into advanced functional nanocomposites and hybrids with the predesigned hierarchical structure and high-performance is attractive, especially for natural biological nanomaterials, such as proteins and polysaccharides. Herein, a simple and sustainable approach called interfacial NP complexation (INC) was applied to construct diverse functional (conductive, drug-loaded, or antimicrobial) nanocomposite filaments from oppositely charged colloidal nanocelluloses. By incorporating different additives during the INC process, including multiwalled carbon nanotube, an antitumor drug (doxorubicin hydrochloride), and metal (silver) NPs (Ag NPs), high-performance functional continuous filaments were synthesized, and their potential applications in electronics, drug delivery, and antimicrobial materials were investigated, respectively. This novel INC method based on charged colloidal NPs opens new avenues for building various functional filaments for a diversity of end uses. ...
Nonvolatile Electrical Bistability Behaviors Observed in Au/Ag Nanoparticle-Embedded MOFs and Switching Mechanisms
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-03 ,DOI:10.1021/acsami.9b17000
Electrically bistable devices play an important role in the next generation of information materials. Plasmonic noble metal nanoparticles (Au and Ag NPs) with diameters <6 nm were embedded into 3-D Cd-based metal–organic framework (MOF) matrixes via the photoreduction method to generate Au (Ag) NPs@MOF composites. Electrical bistability measurements on the sandwiched ITO/NPs@MOF/silver devices indicate that two switchable conductivity states with nonvolatile memory behaviors can be observed. The ITO/Au NP@2/Ag device with neutral matrix possesses the highest ON/OFF current ratio of 104, which can be attributed to its higher electron tunneling efficiency because of the better dispersity of Au NPs in the MOF matrix. A mechanism regarding the electric-field-induced charge-transfer process assisted by conformational change in the active layer was proposed. ...
Light-Activatable Prodrug and AIEgen Copolymer Nanoparticle for Dual-Drug Monitoring and Combination Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-08 ,DOI:10.1021/acsami.9b02346
Polyprodrug nanoparticles have been employed recently for safer and more effective cancer treatment. However, it remains a challenge to elucidate how and when the polyprodrug nanoparticles are dissociated and activated to release active drugs in cancer cells. Herein, a visible light-activatable Pt(IV) prodrug and an aggregation-induced emission luminogen (AIEgen) were copolymerized and embedded in the main chain of PtAIECP, and the chemotherapeutic doxorubicin (DOX) was subsequently encapsulated in the nanoparticles self-assembled by PtAIECP (PtAIECP@DOX NP). PtAIECP@DOX NP enabled the monitoring of both the light-activation of Pt(IV) prodrug to active Pt(II) and release of encapsulated DOX intracellularly through the fluorescence “turn-on” in the course of visible-light-induced polymer-main-chain cleavage and self-assembled structure dissociation in vitro and ex vivo. The synergistic anticancer efficacy of the activated Pt(II) drug and DOX in PtAIECP@DOX NP was also investigated in vitro and in vivo. The implementation of polyprodrug and AIE combination strategy empowered dual drug release and monitoring, which could be further used to guide the temporal and spatial control of light irradiation to maximize therapeutic efficiency, and will inspire other combinational bioimaging and therapy strategies. ...
Temperature-Responsive Hydrophobic Silica Nanoparticle Ultrasound Contrast Agents Directed by Phospholipid Phase Behavior
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-23 ,DOI:10.1021/acsami.8b22659
In this paper, we report ultrasonically active nanoscale contrast agents that behave as thermometric sensors through phase change in their stabilizing phospholipid monolayer. Phospholipid-stabilized, hydrophobic mesoporous silica nanoparticles (P@hMSNs) are known to interact with high-intensity focused ultrasound (HIFU) to promote cavitation at their surfaces, which can be used for both imaging and therapy. We show that the lateral lipid phase behavior of the phosphocholine lipid dictates the acoustic contrast of the P@hMSNs. When the lipids are in the gel phase below their melting temperature, the P@hMSNs generate detectable microbubbles when exposed to HIFU. However, if the lipids exhibit a liquid expanded phase, the P@hMSNs cease to generate bubbles in response to HIFU insonation. We verify that the heating and subsequent transition of lipid coating the hMSN are associated with the loss of acoustic response by doping laurdan dye into the lipid monolayer and imaging lipid phase through red shifts in emission spectra. Similarly, cessation of cavitation was also induced by adding a fluidizing surfactant such as Triton X, which could be reversed upon washing away the excess surfactant. Finally, by controlling for the partial fluidization caused by the adsorption of protein, P@hMSNs may be used as thermometric sensors of the bulk fluid temperature. These findings not only impact the utilization of nanoscale agents as stimulus-responsive ultrasound contrast agents but also have broader implications for how cavitation may be initiated at surfaces coated by a surfactant. ...
Ag-Nanoparticle-Bearing Poly(vinylidene fluoride) Nanofiber Mats as Janus Filters for Catalysis and Separation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-08 ,DOI:10.1021/acsami.8b20759
Hydrophilic Ag nanoparticles were pattern-deposited onto one side of an electrospun poly(vinylidene fluoride) (PVDF) nanofiber mat, yielding a Janus filter. The filter was used to separate a receiver cell from a reactor cell that contained an aqueous 4-nitrophenol/NaBH4 solution. Upon contact with this solution, the Ag nanoparticles catalyzed the reduction of 4-nitrophenol to 4-aminophenol. After the reaction reached completion, ethyl acetate was added into the reactor to extract the product. During this process, the ethyl acetate containing 4-aminophenol also selectively permeated regions of the hydrophobic yet oleophilic PVDF mat that were not covered by Ag nanoparticles. The product was obtained after the evaporation of ethyl acetate. This paper demonstrates the first use of a Janus filter in a catalytic separatory reactor that catalyzes a chemical reaction and then facilitates the eventual separation of the formed product via filtration. ...
Efficient Endocytosis of Inorganic Nanoparticles with Zwitterionic Surface Functionalization
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-10 ,DOI:10.1021/acsami.9b12398
This approach can readily be transferred to other nanoparticle systems offering a wealth of unique properties, with great potential for intracellular bioapplications. ...
Sensing Nitrogen Mustard Gas Simulant at the ppb Scale via Selective Dual-Site Activation at Au/Mn3O4 Interfaces
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-21 ,DOI:10.1021/acsami.9b04875
In addition, the tuneability of selectivity patterns as a function of metal nanoparticle nature paves the way to the development of efficient and selective devices for practical end uses. ...
Surfactant-Augmented Functional Silica Nanoparticle Based Nanofluid for Enhanced Oil Recovery at High Temperature and Salinity
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-27 ,DOI:10.1021/acsami.9b16960
Nanofluids in recent years have shown great potential as a chemical enhanced oil recovery (EOR) technology, thanks to their excellent performance in altering interfacial properties. However, because of the great challenge in preparing stable systems suitable for an elevated temperature and a high salinity environment, expanding the application of nanofluids has been greatly restrained. In this work, a novel nanofluid was prepared by integrating positively charged amino-terminated silica nanoparticles (SiNP-NH2) with negatively charged anionic surfactant (Soloterra 964) via electrostatic force. The resulted nanofluid could be stored at relatively high salinity (15 wt % NaCl solution) and high temperature (65 °C) for more than 30 days without aggregation. Successful coating of the surfactant on target SiNPs was verified by Fourier transform infrared spectrometry and the surface charge and size distribution. In addition, the potential of the nanofluid in recovering oil was investigated by analyzing the nanofluid/Bakken oil interfacial tension and the variation trend of the oil contact angle when brine was replaced by nanofluids. Experimental results showed that the water–oil interfacial tension of the Bakken crude oil decreased by 99.85% and the contact angle increased by 237.8% compared to the original value of 13.78 mN/m and 43.4°, respectively, indicating strong oil displacement efficiency and obvious wetting transition from oil-wet toward water-wet. Spontaneous imbibition tests conducted on Berea rocks showed that the nanofluid yielded a high oil recovery rate of 46.61%, compared to that of 11.30, 16.58, and 22.89% for brine, pure SiNP-NH2, and pure surfactant (Soloterra 964), respectively. In addition, when core flooding was applied, a total of 60.88% of the original oil in place could be recovered and an additional oil recovery of 17.23% was achieved in the chemical flooding stage. Moreover, a possible mechanism of the EOR using the nanofluid was proposed. Overall, the developed nanofluid is a promising new material for EOR. ...
Decoding Live Cell Interactions with Multi-Nanoparticle Systems: Differential Implications for Uptake, Trafficking, and Gene Regulation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-04 ,DOI:10.1021/acsami.9b11315
Surface modification with oligonucleotides renders gold nanoparticles to endocytose through very different pathways as compared to unmodified ones. Such oligonucleotide-modified gold nanoparticles (OGNs) have been exploited as effective nanocarriers for gene regulation therapies. Notably, in an effort to reduce overall dosage and provide safer transition to the clinic, cooperative systems composed of two or more discrete nanomaterials have been recently proposed as an alternative to intrinsically multifunctional nanoparticles. Yet, our understanding of such systems designed to synergistically cooperate in their diagnostic or therapeutic functions remains acutely limited. Specifically, cellular interactions and uptake of OGNs are poorly understood when the cell simultaneously interacts with other types of nanoparticles. Here, we investigated the impact of simultaneous uptake of similar-sized iron oxide nanoparticles (IOPs) on the endocytosis and gene regulation function of OGNs, whose analogues have been proposed for sensitization, targeting, and treatment of tumors. We discovered that both the OGN uptake amount and, remarkably, the gene regulation function remained stable when exposed to a very wide range of extracellular concentrations of IOPs. Additionally, the co-localization analysis showed that a proportion of OGNs was co-localized with IOPs inside cells, which hints at the presence of similar trafficking pathways for OGNs and IOPs following endocytosis. Taken together, our observations indicate that while the OGN endocytosis is highly independent of the IOP endocytosis, it shares transport pathways inside cells—but does so without affecting the gene regulation behavior. These results provide key insights into concomitant interactions of cells with diverse nanoparticles and offer a basis for the future design and optimization of cooperative nanomaterials for diverse theranostic applications. ...
Magnetically Stimulated Drug Release Using Nanoparticles Capped by Self-Assembling Peptides
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-12 ,DOI:10.1021/acsami.9b13614
A novel self-assembling peptide-functionalized core–shell mesoporous silica nanoparticle was developed as a drug carrier. Superparamagnetic manganese- and cobalt-doped iron oxide nanoparticles formed the core for the mesoporous silica shell coating. ...
pH-Sensitive Visible or Shortwave Infrared Quantum Dot Nanoprobes Using Conformation-Switchable Copolymeric Ligands
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-02 ,DOI:10.1021/acsami.9b06194
The central fluorescent QD is coated with a copolymer ligand and conjugated to gold nanoparticlequenchers. ...
Binding Conductive Ink Initiatively and Strongly: Transparent and Thermally Stable Cellulose Nanopaper as a Promising Substrate for Flexible Electronics
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-24 ,DOI:10.1021/acsami.9b04596
Here, inspired by the Ag–S bond theory, a novel cellulose nanopaper substrate is presented to improve the bond strength with the Ag nanoparticle ink through a facile printing method. ...
Efficient Luminescence Enhancement of Mg2TiO4:Mn4+ Red Phosphor by Incorporating Plasmonic Ag@SiO2 Nanoparticles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-22 ,DOI:10.1021/acsami.9b05781
Collective, so-called plasmon, oscillations of surface electrons in a nanoparticle can resonantly interact with incident or fluorescent light and cause an increase in the light absorption cross section or radiative rate for an adjacent emitter. ...
Chemical Imaging of Buried Interfaces in Organic–Inorganic Devices Using Focused Ion Beam-Time-of-Flight-Secondary-Ion Mass Spectrometry
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-17 ,DOI:10.1021/acsami.8b15091
The methodology is evaluated for two additive manufactured devices, an encapsulated strain sensor containing silver tracks embedded in a polymeric material and a copper track on a flexible polymeric substrate created using a novel nanoparticle sintering technique. ...
Self-Optimized Catalysts: Hot-Electron Driven Photosynthesis of Catalytic Photocathodes
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-17 ,DOI:10.1021/acsami.9b10913
Hot electrons drive the deposition of Pt cocatalyst nanoparticles, without any nanoparticlefunctionalization and negligible applied bias, close to the hotspots of the plasmonic nanoislands. The presence of TiO2 is crucial for achieving higher chemical reaction rates. ...
Hierarchical Cellular Structured Ceramic Nanofibrous Aerogels with Temperature-Invariant Superelasticity for Thermal Insulation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-02 ,DOI:10.1021/acsami.9b10018
Herein, we designed and synthesized a hierarchical cellular structured silica nanofibrous aerogel by using electrospun SiO2 nanofibers (SNFs) and SiO2 nanoparticle aerogels (SNAs) as the matrix and SiO2 sol as the high-temperature nanoglue. ...
How Does a Plasmon-Induced Hot Charge Carrier Break a C–C Bond?
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-25 ,DOI:10.1021/acsami.9b05509
Hot-electron chemistry at gold nanoparticle (AuNP) surfaces has received much attention recently because its understanding provides a basis for plasmonic photocatalysis and photovoltaics. ...
Chemical Control of Electronic Coupling between a Ruthenium Complex and Gold Electrode for Resonant Tunneling Conduction
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-25 ,DOI:10.1021/acsami.9b05569
We used a nanoparticle bridge junction to investigate the effect of electronic coupling between a Ru complex and electrodes on nonlinear electrical properties. ...
Correction to "Noncovalent PEG Coating of Nanoparticle Drug Carriers Improves the Local Pharmacokinetics of Rectal Anti-HIV Microbicides".
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-23 ,DOI:10.1021/acsami.8b22242


Dual-Blockade Immune Checkpoint for Breast Cancer Treatment Based on a Tumor-Penetrating Peptide Assembling Nanoparticle
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-18 ,DOI:10.1021/acsami.9b13354
Cancer immunotherapy can enhance the antitumor effect of drugs through a combinatorial approach in a synergistic manner. However, the effective targeted delivery of various drugs remains a challenge. We generated a peptide assembling tumor-targeted nanodelivery system based on a breast cancer homing and penetrating peptide for the codelivery of a programmed cell death ligand 1 (PD-L1) small interfering RNA (siRNA) (siPD-L1) and an indoleamine 2,3-dioxygenase inhibitor as a dual blockade of an immune checkpoint. The vector is capable of specifically accumulating in the breast cancer tumor site in a way that allows the siRNA to escape from endosomal vesicles after being endocytosed by tumor cells. The drug within these cells then acts to block tryptophan metabolism. The results showed that locally released siPD-L1 and 1-methyl-dl-tryptophan favor the survival and activation of cytotoxic T lymphocytes, resulting in apoptosis of breast cancer cells. Therefore, this study provides a potential approach for treating breast cancer by blocking immunological checkpoints through the assembly of micelles with functional peptides. ...
Energetics of Nonradiative Surface Trap States in Nanoparticles Monitored by Time-of-Flight Photoconduction Measurements on Nanoparticle–Polymer Blends
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-25 ,DOI:10.1021/acsami.9b07852
Nanoparticles (NPs) have had increasingly successful applications including in emissive or photovoltaic devices; however, trap states associated with the surface of NPs often drastically reduce the efficiency of devices and are difficult to detect spectroscopically. We show the applicability of photoconduction as the means of detecting and quantifying trap states in NPs. We performed time-of-flight (ToF) photoconduction measurements, using semiconducting poly[bis(4-phenyl)(4-butyphenyl)amine] (P-TPD) doped with either core/shell CdSeS/CdS quantum dots (QDs) or perovskite CsPbBr3 NPs, both of which are carefully designed to be energetically matched. In the case of the QDs, a drop in the hole mobility from ∼10–3 to ∼10–4 cm2 V–1 s–1 was observed when compared to a control sample, suggesting the presence of a hole trapping. These trap states were found to be around −5.0 to −4.9 eV from the vacuum level. The presence of the trap states was further supported by a coincident reduction in the photoluminescence (PL), quantum yield (QY), and lifetime of the core/shell QDs after purification. Using the measured reductions in the PL, QY, and lifetime, the surface trap state density was estimated to increase by between 20 and 40%, most likely due to a ligand detachment. In the case of the perovskite NP-doped samples, a mobility of ∼10–3 cm2 V–1 s–1 was measured. Thus, doping with perovskite NPs did not generate any obvious hole trapping from the P-TPD matrix. The absence of a trapping may be related to the reduced surface-to-volume ratio and NP number density of the perovskite NPs compared to the core/shell QDs, since the perovskite NPs are approximately 10 times larger in radius than that of the core/shell QDs. Our results suggest that to minimize the presence of trap states with a view to improving device performance, large-size perovskite NPs appear to be better than small-size QDs. ...
Magnetic Nanoparticle Relaxation Dynamics-Based Magnetic Particle Spectroscopy for Rapid and Wash-Free Molecular Sensing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-19 ,DOI:10.1021/acsami.9b05233
Magnetic nanoparticles (MNPs) have been extensively used as contrasts and tracers for bioimaging, heating sources for tumor therapy, carriers for controlled drug delivery, and labels for magnetic immunoassays. Here, we describe a MNP Brownian relaxation dynamics-based magnetic particle spectroscopy (MPS) method for the quantitative detection of molecular biomarkers. In MPS measurements, the harmonics of oscillating MNPs are recorded and used as a metric for the freedom of rotational motion, which indicates the bound states of the MNPs. These harmonics can be collected from microgram quantities of iron oxide nanoparticles within 10 s. As the harmonics are largely dependent on the quantity of the MNPs in the sample, the MPS bioassay results could be biased by the deviations of MNP quantities in each sample, especially for the very low-concentration biomarker detection scenarios. Herein, we report three MNP concentration/quantity-independent metrics for characterizing the bound states of MNPs in MPS. Using a streptavidin–biotin binding system as a model, we demonstrate the feasibility of using MPS and MNP concentration/quantity-independent metrics to sense these molecular interactions, showing that this method can achieve rapid, wash-free bioassays, and is suitable for future point-of-care, sensitive, and versatile diagnosis. ...
Engineered Cell-Assisted Photoactive Nanoparticle Delivery for Image-Guided Synergistic Photodynamic/Photothermal Therapy of Cancer
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-04 ,DOI:10.1021/acsami.9b00022
Photoactivated therapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is a spatiotemporally precise, controllable, and noninvasive method for tumor therapy and has therefore attracted increasing attention in recent years. However, it is still a challenge to obtain highly efficient therapeutic photoactive agents (PAAs) and deliver them into tumor, especially the core of solid tumors. Here, we have developed a newly engineered monocyte (MNC)-based PAA system that realizes precise and highly efficient tumor diagnosis and therapy. First, a near-infrared emissive PAA molecule with both strong singlet oxygen (1O2) production and high photothermal conversion efficiency was precisely designed for realizing simultaneous PDT and PTT of tumor and was further fabricated to form PAA nanoparticles (NPs). After loading the PAA NPs into MNCs, the MNCs were then decorated with cyclic Arg-Gly-Asp (cRGD) groups through a metabolic labeling method to further improve their ability of targeting and homing into the deep regions of tumors. Using this strategy, we have achieved highly efficient solid tumor ablation results both in vitro and in vivo, indicating that our strategy has a promising prospect for solid tumor therapy. ...
Transparent Bioreactors Based on Nanoparticle-Coated Liquid Marbles for in Situ Observation of Suspending Embryonic Body Formation and Differentiation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-19 ,DOI:10.1021/acsami.8b20169
Transparent liquid marbles coated with hydrophobic silica nanoparticles were used as micro-bioreactors for embryonic stem cell (ESC) culturing. The high transparency of silica liquid marbles enables real-time and in situ monitoring of embryonic body (EB) formation and differentiation. The experimental result shows that ESCs can aggregate with each other close to the bottom of the liquid marble and form EBs, while remaining suspended in the culture media. The differentiation of the suspending EBs into contractile cardiomyocytes has been demonstrated inside the transparent liquid marbles, which enable the in situ microscopic observation. It was also found, through comparison, that ESCs in a bare sessile drop placed on a superhydrophobic substrate tend to anchor onto the substrate and then differentiate following the normal way of cell spreading, i.e., withdrawal from the cell cycle, fusion with nascent myotubes, and final differentiation into cardiomyocytes. In contrast, liquid marble particle shells weaken the adhesion of spherical EBs to the substrate, encouraging them to differentiate in suspension into cardiomyocytes, without anchoring. The results of this study highlight the promising performance of liquid marbles as “one-pot” micro-bioreactors for EB formation and differentiation. ...
Carbohydrate-Coated Gold–Silver Nanoparticles for Efficient Elimination of Multidrug Resistant Bacteria and in Vivo Wound Healing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-11 ,DOI:10.1021/acsami.9b17086
We conclude that this bimetallic nanoparticle can be safe in complete skin regeneration in bacteria infected wounds. ...
Amphiphilic Polymer-Mediated Aggregation-Induced Emission Nanoparticles for Highly Sensitive Organophosphorus Pesticide Biosensing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-29 ,DOI:10.1021/acsami.9b10237
This study not only provides new possibilities to fabricate novel AIE nanoparticles with exceptional properties, but also facilitates the AIE nanoparticle’s application for target analyte biosensing. ...
Self-Emitting Artificial Cilia Produced by Field Effect Spinning
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-06 ,DOI:10.1021/acsami.9b09571
The red, green, and blue emission characteristics of the polymer-quantum dot-based self-emitting artificial cilia prepared in polymer–inorganic nanoparticle hybrid form were determined. In addition, an artificial cilia-based humidity sensor made of the polymer–polymer composite was fabricated. ...
Nonflammable Fluorinated Carbonate Electrolyte with High Salt-to-Solvent Ratios Enables Stable Silicon-Based Anode for Next-Generation Lithium-Ion Batteries
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-19 ,DOI:10.1021/acsami.9b05570
It is revealed that this electrolyte could not only enhance the cycling stability toward the silicon nanoparticle (SiNPs) anode but also solve the safety hazards. ...
Monodispersed CuSe Sensitized Covalent Organic Framework Photosensitizer with an Enhanced Photodynamic and Photothermal Effect for Cancer Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-18 ,DOI:10.1021/acsami.9b08394
The as-synthesized nonporphyrin containing COF nanoparticle was employed as a novel photosensitizer for PDT, which exhibited an excellent photodynamic effect under 650 or 808 nm laser irradiation. ...
Auxetic Thermoresponsive Nanoplasmonic Optical Switch
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-11 ,DOI:10.1021/acsami.9b05530
We show that such meta-surfaces can be tuned to exhibit substantial changes in the optical properties in terms of both wavelength and intensity, through the temperature-controlled variation of the interparticle distance within the nanoparticle monolayer as well as its separation from the substrate. ...
Poly(ionic liquid) Electrolytes for a Switchable Silver Mirror
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-22 ,DOI:10.1021/acsami.9b05001
Because of several unique properties of PILs, the PIL-based REM exhibits fast switching speeds, superb cycling durability, small particle sizes, and uniform electrodeposited Ag nanoparticle films. ...
Simple-Structured Micromotors Based on Inherent Asymmetry in Crystalline Phases: Design, Large-Scale Preparation, and Environmental Application
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-29 ,DOI:10.1021/acsami.9b03579
The key principle of designing a micro/nanomotor is to introduce asymmetry to a micro/nanoparticle. ...
Fluorescent Aerogels Based on Chemical Crosslinking between Nanocellulose and Carbon Dots for Optical Sensor
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-22 ,DOI:10.1021/acsami.9b02754
Besides improved mechanical properties with a 360% increase in compression strength, the covalently bonded CD nanoparticle further serves as a structural stabilizer to endow the characteristic of shape recovery in water for the fabricated fluorescent aerogel. ...
Hybridized Guided-Mode Resonances via Colloidal Plasmonic Self-Assembled Grating
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-27 ,DOI:10.1021/acsami.8b20535
Compared to metallic grids, the observation range of hybridized guided modes can now be extended to modes along the nanoparticle chain lines. ...
Coupling Ultrafine Pt Nanocrystals over the Fe2P Surface as a Robust Catalyst for Alcohol Fuel Electro-Oxidation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-21 ,DOI:10.1021/acsami.8b18029
Defects and increased surface area of the petaloid Fe2P are beneficial to the Pt nanoparticle anchoring and dispersion as well as the charge transfer and reactant transportation during the electrochemical reaction. ...
Ultrasensitive Electrochemical Methane Sensors Based on Solid Polymer Electrolyte-Infused Laser-Induced Graphene
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-30 ,DOI:10.1021/acsami.8b22310
Porous, laser-induced graphene (LIG) electrodes are patterned directly into commercial polymer films and imbibed with a palladium nanoparticle dispersion to distribute the electrocatalyst within the high surface area support. ...
Three-Dimensional CeO2 Woodpile Nanostructures To Enhance Performance of Enzymatic Glucose Biosensors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-04 ,DOI:10.1021/acsami.8b16985
The fabrication approach, which employs nanoimprint lithography and a CeO2 nanoparticle-based ink, enables the direct, high-throughput patterning of nanostructures and is scalable, integrable, and of low cost. ...
Silver Nanoparticle-Doped 3D Porous Carbon Nanofibers as Separator Coating for Stable Lithium Metal Anodes
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-06 ,DOI:10.1021/acsami.9b04122
The ever-increasing demand for electric devices and vehicles prompts the fast development of energy storage systems. Lithium metal is thought to be the most promising electrode for high-performance batteries. However, the growth of lithium dendrites impedes the industrial production of lithium metal batteries. Herein, an effective approach is proposed by coating a commercial separator with three-dimensional porous carbon fibers loaded with silver nanoparticles (Ag-PCNFs), which can be regarded as a subsidiary of the electrode to improve the cycling performance of lithium metal batteries. The porous structure with a high specific surface area endows the electrode with a high lithium-loading capacity. The silver nanoparticles provide the electrode pro-Li property and excellent electrical conductivity, which are beneficial for the electrochemical reaction and reduce the local current density to attain a dendrite-free electrode. Electrochemical cycling performance of symmetric Li–Li batteries shows that Ag-PCNF coating can hinder dendrite growth and enhance the cycling stability, indicating that Ag-PCNFs acting as host materials can effectively guide the deposition of Li and solve the dendrite problem. ...
Nanoparticle Concentration vs Surface Area in the Interaction of Thiol-Containing Molecules: Toward a Rational Nanoarchitectural Design of Hybrid Materials
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-03 ,DOI:10.1021/acsami.9b03942
The effect of accounting for the total surface in the association of thiol-containing molecules to nanosilver was assessed using isothermal titration calorimetry, along with a new open access algorithm that calculates the total surface area for samples of different polydispersity. Further, we used advanced molecular dynamic calculations to explore the underlying mechanisms for the interaction of the studied molecules in the presence of a nanosilver surface in the form of flat surfaces or as three-dimensional pseudospherical nanostructures. Our data indicate that not only is the total surface area available for binding but also the supramolecular arrangements of the molecules in the near proximity of the nanosilver surface strongly affects the affinity of thiol-containing molecules to nanosilver surfaces. ...
Interface Modified Flexible Printed Conductive Films via Ag2O Nanoparticle Decorated Ag Flake Inks
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-20 ,DOI:10.1021/acsami.8b20057
A new approach to stable, low resistance inexpensive printed flexible conductive inks is proposed. Silver inks have been extensively studied and commercialized for applications in printed electronics due to the inherent high conductivity and stability of silver, even in particulate-based percolation networks processed at temperatures compatible with low-cost polymer films such as poly(ethylene terephthalate) (PET). Recent interest in flexible and even stretchable circuits, however, has presented new challenges for particle-based inks as mechanical strains can result in the opening of critical particle-to-particle contacts. Here we report a facile, low-cost method for the single-step synthesis of stable, printable nanoscale Ag2O decorated Ag flake inks which can be converted to highly conductive Ag films at 150 °C curing temperature without the use of limited shelf life organometallics or low metal loading nanoparticles to modify the interface between silver flakes. Analysis indicates that decoration of Ag flakes with Ag2O nanoparticles (NPs) during ink synthesis improves the conductivity and flexibility of printed silver films by forming bridging interconnections between Ag flakes after low temperature reduction of the Ag2O NPs. In this work, printed nanodecorated silver conductors with starting oxide to metal weight ratios of 5:95 exhibited lateral resistivities lower than 1.5 × 10–5 Ω•cm, which was 35% less than films derived from undecorated Ag flake inks of the same total Ag loading and binder system. This resistivity difference increased to 45% after cyclic bend testing showing increased resilience to repeated flexing for the nanodecorated inks. Through detailed compositional and morphological characterizations, we demonstrate that such improved conductivity and flexibility are due to a more effective bridging afforded by the in situ synthesized Ag NPs on the surface of Ag flakes. These properties, combined with the simplified syntheses method of the nanoink, make the material a viable, advantageous alternative to the limited number of stretchable conductors currently available. ...
Controlled Enhancement in Hole Injection at Gold-Nanoparticle-on-Organic Electrical Contacts Fabricated by Spark-Discharge Aerosol Technique
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-30 ,DOI:10.1021/acsami.8b16303
We demonstrate that hole injection from a top electrode composed of Au nanoparticles (AuNPs) capped with a thick Au layer into an underlying organic semiconductor, N,N′-diphenyl-N,N′-bis-[4-(phenyl-m-tolyl-amino)-phenyl]-biphenyl-4,4′-diamine (DNTPD), is significantly enhanced compared to that in a control device whose top electrode is composed entirely of a thick Au layer. The fabrication of this organic hole-only device with the AuNP electrode is made possible by dry, room-temperature distribution of AuNPs onto DNTPD using a spark-discharge aerosol technique capable of varying the average diameter (D̅) of the AuNPs. The enhancement in hole injection is found to increase with decreasing D̅, with the current density of a device with D̅ = 1.1 nm being more than 3 orders of magnitude larger than that of the control device. Intensity-modulated photocurrent measurements show that the built-in potentials of the devices with the AuNP electrode are smaller than that of the control device by as much as 0.68 V, indicating that the enhanced hole injection originates from the increased work functions of these devices, which in turn decreases the hole injection barrier heights. X-ray photoelectron spectroscopy reveals that the increased work functions of the AuNP electrodes are due to surface oxidation of the AuNPs resulting in AuN and Au3N. The degree of oxidation of the AuNPs increases with decreasing D̅, consistent with the D̅-dependencies of the hole injection enhancement and the built-in potential reduction. ...
Rebuilding Postinfarcted Cardiac Functions by Injecting TIIA@PDA Nanoparticle-Cross-linked ROS-Sensitive Hydrogels
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-10 ,DOI:10.1021/acsami.8b20158
Drug-loaded injectable hydrogels have been proven to possess huge potential for applications in tissue engineering. However, increasing the drug loading capacity and regulating the release system to adapt to the microenvironment after myocardial infarction face a huge challenge. In this research, an ROS-sensitive injectable hydrogel strengthened by self-nanodrugs was constructed. A hyperbranched ROS-sensitive macromer (HB-PBAE) with multiacrylate end groups was synthesized through dynamic controlled Michael addition. Meanwhile, a simple protocol based on dopamine polymerization was employed to generate a polydopamine (PDA) layer deposited on the tanshinone IIA (TIIA) nanoparticles (NPs) formed from spontaneous hydrophobic self-assembly. The HB-PBAE reacted with thiolate-modified hyaluronic acid (HA-SH) to form an in situ hydrogel, where TIIA@PDA NPs can be conveniently entrapped through the chemical cross-link between thiolate and quinone groups on PDA, which doubles the modulus of hydrogels. The in vivo degradation behavior of the hydrogels was characterized by MRI, exhibiting a much slower degradation behavior that is markedly different from that of in vitro. Importantly, a significant improvement of cardiac functions was achieved after hydrogel injection in terms of increased ejection fraction and decreased infarction size, accompanied by inhibition of the expression of inflammation factors, such as IL-1β, IL-6, and TNF-α. ...
Highly Conductive PVA/Ag Coating by Aqueous in Situ Reduction and Its Stretchable Structure for Strain Sensor
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-26 ,DOI:10.1021/acsami.9b15546
Herein, we present a facile approach for fabricating highly conductive, stretchable, and sensitive fiber strain sensors by synthesizing poly(vinyl alcohol)/Ag nanoparticle composite coating through aqueous in situ reduction on a stretchable fiber with a braided structure. ...
Silica-Coated Nanoparticles with a Core of Zinc, l-Arginine, and a Peptide Designed for Oral Delivery
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-18 ,DOI:10.1021/acsami.9b16104
Nanoparticle constructs for oral peptide delivery at a minimum must protect and present the peptide at the small intestinal epithelium in order to achieve oral bioavailability. ...
Interfacial Defect-Mediated Near-Infrared Silicon Photodetection with Metal Oxides
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-04 ,DOI:10.1021/acsami.9b14953
Finally, using this analysis, we demonstrate a gold-nanoparticle-coated photodiode that has three distinct photocurrent responses resulting from hot carriers in the gold, interface defects from the AZO, and bulk defects within the Si. ...
Encapsulation of Ionic Liquids for Tailored Applications
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-26 ,DOI:10.1021/acsami.9b16546
Specifically, we have developed the ability to use 2D carbon nanoparticle surfactants and interfacial polymerization to prepare capsules of IL using both IL-in-water and IL-in-oil Pickering emulsions as templates. ...
Accelerated Design of Catalytic Water-Cleaning Nanomotors via Machine Learning
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-18 ,DOI:10.1021/acsami.9b14792
However, the vast variety of nanoparticle designs prevents rapid identification of the optimal composition for a given application. ...
Smart Unimolecular Micelle-Based Polyprodrug with Dual-Redox Stimuli Response for Tumor Microenvironment: Enhanced in Vivo Delivery Efficiency and Tumor Penetration
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-18 ,DOI:10.1021/acsami.9b13214
Low delivery efficiency and limited tumor penetration of nanoparticle-based drug delivery systems (DDSs), the two most concerned issues in tumor therapy, have been considered as the “Achilles’ heel” for tumor treatment. ...
Multifunctional Liquid Marble Compound Lenses
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-10 ,DOI:10.1021/acsami.9b12738
At the nanometer to micrometer length scale we employ nanoparticle-stabilized emulsion droplets of photocurable oil to form microlenses with nanoscale surface features. ...
Direct Ink Writing of Poly(tetrafluoroethylene) (PTFE) with Tunable Mechanical Properties
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-23 ,DOI:10.1021/acsami.9b07279
Our approach is based on a newly formulated PTFE nanoparticle ink and thermal treatment process. The ink was formulated by mixing an aqueous dispersion of surfactant-stabilized PTFE nanoparticles with a binding gum to optimize its shear-thinning properties required for DIW. ...
Self-Supported Hierarchical IrO2@NiO Nanoflake Arrays as an Efficient and Durable Catalyst for Electrochemical Oxygen Evolution
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-11 ,DOI:10.1021/acsami.9b05785
Here, a rational design of a self-supported hierarchical nanocomposite, composed of IrO2@NiO nanoparticle-built porous nanoflake arrays vertically growing on nickel foam, is proposed, which is demonstrated as a versatile strategy to achieve improved OER activity, remarkable long-term stability, and significantly ...
Acidic pH-Activated Gas-Generating Nanoparticles with Pullulan Decorating for Hepatoma-Targeted Ultrasound Imaging
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-14 ,DOI:10.1021/acsami.9b06745
Therefore, the presented CPP hybrid nanoparticle is a promising contrast agent for effective US imaging of hepatoma. ...
Observation of ZrNb14O37 Nanowires as a Lithium Container via In Situ and Ex Situ Techniques for High-Performance Lithium-Ion Batteries
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-12 ,DOI:10.1021/acsami.9b05841
Here, ZrNb14O37 nanowires are fabricated via a facile electrospinning method, presenting a nanoparticle-in-nanowire architecture. ...
Scalable Light-Printing of Substrate-Engraved Free-Form Metasurfaces
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-11 ,DOI:10.1021/acsami.9b07135
We show that masking by the local nanoparticle distribution, and, therefore, the local index, is dependent on the local light-induced dewetting temperature. We demonstrate printing of a free-form pattern engraved into a fused silica glass substrate using a laser raster scan. ...
Direct Comparison of PdAu Alloy Thin Films and Nanoparticles upon Hydrogen Exposure
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-18 ,DOI:10.1021/acsami.8b22455
In the literature, two nanostructured systems based on metal hydrides have been proposed for this purpose each with its own detection principle: continuous sub-100 nm thin films read out via optical reflectance/transmittance changes and nanoparticle arrays for which the detection relies on localized ...
Matrix-Independent Highly Conductive Composites for Electrodes and Interconnects in Stretchable Electronics
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-15 ,DOI:10.1021/acsami.8b21836
The ECCs based on silver nanoparticle-covered silver flakes exhibit high conductivity because of the removal of insulating surfactants as well as the enhanced contact between flakes. ...
NIR Light-Degradable Antimony Nanoparticle-Based Drug-Delivery Nanosystem for Synergistic Chemo–Photothermal Therapy in Vitro
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-16 ,DOI:10.1021/acsami.9b20249
A novel drug-delivery nanosystem based on near-infrared (NIR) light-degradable antimony nanoparticles (AMNP) have been developed for synergistic chemo–phototherapy in vitro. The monodispersed AMNP were synthesized by using a simple and cost-effective method. Positively charged doxorubicin hydrochloride (DOX) was loaded onto the negatively charged surface of AMNP via electrostatic interaction and finally modified by polyacrylic acid (PAA) to enhance biocompatibility. Under NIR (808 nm) laser irradiation of the AMNP–DOX–PAA nanosystem, not only was high photothermal conversion efficiency of AMNP achieved but also pH-dependent DOX release was enhanced due to laser-induced hyperthermia. As a consequence, almost all of the HeLa cells (around 97%) were killed because of the combined effects of chemotherapy and photothermal therapy. More interestingly, AMNP showed very fast (about 10 min) laser-induced degradation that may help to minimize long-term toxicity after therapy by using same-wavelength NIR laser irradiation (808 nm). Computational total energy calculations and molecular dynamics simulations based on density functional theory (DFT) suggest that the NIR laser irradiation induces a photothermally activated reaction on the surface of AMNP in water, which can lead to surface degradation via the formation of Sb–H bonds first and then Sb–OH bonds upon further increase of temperature. This work demonstrates a simple platform that has potential applications for synergistic and highly effective chemo–photothermal therapy based on photodegradable nanoparticles. ...
Near-Infrared-Responsive Photoelectrochemical Aptasensing Platform Based on Plasmonic Nanoparticle-Decorated Two-Dimensional Photonic Crystals
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-06 ,DOI:10.1021/acsami.9b07128
The photoelectrochemical (PEC) analysis is an emerging and fast developing biosensing technique. However, the in vivo PEC biosensing in deep tissue is seriously hampered because of the shallow penetration depth of ultraviolet and visible light. Expanding the optical absorption wavelength of photoelectrodes from the visible light region into the near-infrared (NIR) light region is highly desirable because of its deep tissue penetrability and minimal invasiveness for organisms, but the exploration of the facile strategy to implement efficient NIR absorption with good biocompatibility is still challenging. Herein, a NIR PEC aptasensor is proposed by coupling plasmonic nanoparticles (NPs) into periodic two-dimensional nanocavity (NC) photonic crystals as photoelectrodes, where the Au NPs are sputtered on a periodic two-dimensional TiO2 NC photonic crystal substrate to significantly enhance the NIR PEC response and successfully achieve sensitive PEC detection of Hg2+ under irradiation of NIR light in blood. We believe that the proposed NIR-responsive Au/TiO2 NC-based PEC aptasensor will open a new in vivo biosensing model for a series of important biomolecules and pave up an avenue for the practical applications of PEC biosensing in deep tissue or even in organs and brain of the living body. ...
Chromium Cross-Linking Based Immobilization of Silver Nanoparticle Coating on Leather Surface with Broad-Spectrum Antimicrobial Activity and Durability
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-02 ,DOI:10.1021/acsami.8b17061
Leather with durable and broad-spectrum antimicrobial properties is very attractive in applications to produce diabetic shoes. In this work, gallic acid stabilized silver nanoparticles (GA@AgNPs) were prepared as water-borne finishing agent to be spray-coated on leather surface, with subsequent immobilization onto skin collagen via chromium(III) cross-linking. Such chemical anchoring of AgNPs onto microscaled collagen fibers not only enhanced the hydrophobicity of leather surface but also converted the surface ζ-potential from a positive charge to a negative charge, resulting in the excellent microbial antiadhesive ability of GA@AgNP-coated leather because of its dual-hydrophobic and electrostatic repelling of microbial adhesion. Such GA@AgNP coating also exhibited broad-spectrum antimicrobial activity against Escherichia coli, Staphylococcus aureus, methicillin-resistant S. aureus, and Candida albicans, with killing efficiencies all higher than 99%. Moreover, the killed microbes could be easily released from this anionic GA@AgNP spray coating by simply washing, preserving, and giving long-term antimicrobial activity to leather products. Most of all, the robust immobilization of AgNPs guaranteed the durably antimicrobial activity of such GA@AgNP-coated leather against laundry, perspiration, and mechanical abrasion in real daily use. ...
Highly Intensified Molecular Oxygen Activation on [email protected]2MoO6 via a Metallic Bi-Coordinated Facet-Dependent Effect
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-27 ,DOI:10.1021/acsami.9b17623
Density functional theory and systematical characterization methods reveal the distinct charge transfer and O2 activation processes on the surface of Bi nanoparticle-deposited Bi2MoO6 nanosheets with different facets exposed. ...
Design of an Ultrasensitive Flexible Bend Sensor Using a Silver-Doped Oriented Poly(vinylidene fluoride) Nanofiber Web for Respiratory Monitoring
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-24 ,DOI:10.1021/acsami.9b18823
The unique electrospinning (rotational speed of collector of 2000 rpm and tip-to-collector distance of 4 cm) with silver nanoparticle interfacing was introduced to prepare a Ag-doped oriented PVDF nanofiber web with high β-phase content as a sensing element (AgOriPVDF, β-phase crystallinity ∼44.5%). ...
Ultrasmall TPGS–PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into Pseudomonas aeruginosa Biofilms in Lungs
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-17 ,DOI:10.1021/acsami.9b19644
Here, we present an “environment-adaptive” nanoparticle composed of a solid poly lactic-co-glycolic acid (PLGA) core and a mucus-inert, enzymatically cleavable shell of d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) for the site-specific delivery of antibiotics to bacterial biofilms via aerosol ...
Ultrasmall Designed Plasmon Resonators by Fused Colloidal Nanopatterning
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-19 ,DOI:10.1021/acsami.9b15780
The heights and widths of the plasmon resonators are determined by the diameter of the nanoparticlebuilding blocks, which can be well below 10 nm. ...
An Assembly and Interfacial Templating Route to Carbon Supercapacitors with Simultaneously Tailored Meso- and Microstructures
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-07 ,DOI:10.1021/acsami.9b15058
Here, we synthesize three-dimensionally ordered hierarchically porous carbon powders by the assembly of glucose with silica nanoparticle building blocks of sacrificial NP-crystalline templates. ...
Joule-Heated and Suspended Silicon Nanowire Based Sensor for Low-Power and Stable Hydrogen Detection
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-30 ,DOI:10.1021/acsami.9b15111
We proposed a H2 sensing model using oxygen adsorption on the Pd nanoparticle-coated silicon oxide surface to understand the H2 response of Joule-heated Pd-SiNWs. ...
An Acoustic Droplet-Induced Enzyme Responsive Platform for the Capture and On-Demand Release of Single Circulating Tumor Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-25 ,DOI:10.1021/acsami.9b16566
The platform combines a multifunctional enzyme-responsive gelatin nanoparticle (GNP)-decorated substrate (GNP-chip) for specific capture with an acoustic droplet positioning technique to realize on-demand release of single CTCs. ...
Electric Field-Driven Interfacial Alloying for in Situ Fabrication of Nano-Mo2C on Carbon Fabric as Cathode toward Efficient Hydrogen Generation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-11 ,DOI:10.1021/acsami.9b11253
MoS2, evenly coated on carbon cloth (CC), is electrochemically reduced in situ and readily reacts with the carbon fibers of CC current collector to form a Mo2C nanoparticle layer. ...
Alternative and Injectable Preformed Albumin-Bound Anticancer Drug Delivery System for Anticancer and Antimetastasis Treatment
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-30 ,DOI:10.1021/acsami.9b11307
The lack of any chemical reactions preserves HSA bioactivity, in contrast to the destroyed secondary structure within AN-THP (albumin nanoparticle of THP) for the harsh manipulation during preparation. ...
Inorganic Perovskite-Induced Synergy on Highly Selective Pd-Catalyzed Hydrogenation of Cinnamaldehyde
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-28 ,DOI:10.1021/acsami.9b10820
Herein, we report on the synthesis of highly selective palladium nanoparticle (Pd NP)-containing catalysts. The heterogeneous catalysts reported herein consist of active mixed-metal oxides, in the form of perovskites as catalysts, and as catalytic supports for Pd NPs. ...
Approaching Durable Single-Layer Fuel Cells: Promotion of Electroactivity and Charge Separation via Nanoalloy Redox Exsolution
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-23 ,DOI:10.1021/acsami.9b08448
The precipitated metal/alloy nanoparticle on perovskite oxide not only improves the electrode reaction kinetics but also facilitates the charge separation and ionic conduction in SLFCs, consequently enhancing the fuel cell performance and electrical efficiency. ...
Nitrogen Plasma-Treated Core–Bishell Si@SiOx@TiO2−δ: Nanoparticles with Significantly Improved Lithium Storage Performance
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-29 ,DOI:10.1021/acsami.9b04415
To overcome these challenges, in the present study, we designed a nitrogen plasma-treated core–bishell nanostructure where the Si nanoparticle was encapsulated into a SiOx shell and N-doped TiO2−δ shell. ...
Porous Nb4N5/rGO Nanocomposite for Ultrahigh-Energy-Density Lithium-Ion Hybrid Capacitor
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-27 ,DOI:10.1021/acsami.9b06351
Therefore, the Nb4N5/rGO nanocomposite exhibits a higher reversible specific capacity and better rate and cycling performance than the Nb4N5 nanoparticle. ...
Control of SEI Formation for Stable Potassium-Ion Battery Anodes by Bi-MOF-Derived Nanocomposites
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-11 ,DOI:10.1021/acsami.9b06379
Herein, we developed novel ultrathin carbon film@carbon nanorods@Bi nanoparticle (UCF@CNs@BiN) materials for the long cycle life anode of PIBs. ...
Ultralong Cycle Life Li–O2 Battery Enabled by a MOF-Derived Ruthenium–Carbon Composite Catalyst with a Durable Regenerative Surface
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-24 ,DOI:10.1021/acsami.9b05235
Herein, we reported a novel Ru-metal–organic framework (MOF)-derived carbon composite, characterized by stereoscopic Ru nanoparticle distribution within the carbon matrix, as an alternative oxygen catalyst of LOBs, enabling superior operational stability and favorable activity. ...
Facile Film-Nanoctahedron Assembly Route to Plasmonic Metamaterial Absorbers at Visible Frequencies
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-24 ,DOI:10.1021/acsami.9b01088
Plasmonic metamaterial absorbers (MAs) with broadband and near-perfect absorption properties in the visible region were successfully fabricated via a facile film-colloidal nanoparticle (NP) assembly method. ...
pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-24 ,DOI:10.1021/acsami.9b04051
Herein, we developed a stimuli-responsive nanoparticle (NP) to target inflammatory lungs for ALI therapies. ...
Light-Triggered Boost of Activity of Catalytic Bola-Type Surfactants by a Plasmonic Metal–Support Interaction Effect
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-16 ,DOI:10.1021/acsami.9b03727
A surfactant with a catalytically active head group, a protonated polyoxometalate (POM) cluster, is attached to the surface of a gold nanoparticle (Au NP) using thiol coupling chemistry. ...
In-Plane Surface Lattice and Higher Order Resonances in Self-Assembled Plasmonic Monolayers: From Substrate-Supported to Free-Standing Thin Films
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-16 ,DOI:10.1021/acsami.9b03197
This enables us to prepare macroscopic, free-standing polymer films with embedded plasmonic nanoparticle arrays, which feature strong surface lattice resonances. ...
Terminal Deoxynucleotidyl Transferase-Catalyzed Preparation of pH-Responsive DNA Nanocarriers for Tumor-Targeted Drug Delivery and Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-15 ,DOI:10.1021/acsami.9b05358
In this strategy, terminal deoxynucleotidyl transferase (TdT)-catalyzed DNA extension reaction is used to prepare a thick DNA layer on a gold nanoparticle (AuNP) surface by extending long poly(C) sequences from DNA primers immobilized on AuNPs. ...
Transformation of Stöber Silica Spheres to Hollow Hierarchical Single-Crystal ZSM-5 Zeolites with Encapsulated Metal Nanocatalysts for Selective Catalysis
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-09 ,DOI:10.1021/acsami.9b00630
These configured nanoscale zeolite catalysts have potential applications for reactions that involve supported metal nanoparticle catalysis, shape selectivity, or secondary cracking reactions. ...
Temporally Controlled Photothermal/Photodynamic and Combined Therapy for Overcoming Multidrug Resistance of Cancer by Polydopamine Nanoclustered Micelles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-02 ,DOI:10.1021/acsami.9b00472
Herein, we report a photoresponsive nanocluster (NC) system prepared by installing polydopamine (PDA) nanoparticle clusters on the surface of d-α-tocopheryl poly(ethylene glycol) 1000 succinate (TPGS) (a drug efflux inhibitor) micelles solubilized with IR780 (a photosensitizer) to achieve a combined ...
In Situ Assembly of a Zeolite Imidazolate Framework Hybrid Thin-Film Nanocomposite Membrane with Enhanced Desalination Performance Induced by Noria–Polyethyleneimine Codeposition
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-22 ,DOI:10.1021/acsami.9b01237
Due to the significantly altered IP process induced by the coexistence of Noria and ZIF-8 on the support surface, the TFN membrane depicts a distinct nanostrand–nanoparticle hybrid morphology, which endows the TFN membrane with excellent antifouling ability. ...
A pH-Triggered, Self-Assembled, and Bioprintable Hybrid Hydrogel Scaffold for Mesenchymal Stem Cell Based Bone Tissue Engineering
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-25 ,DOI:10.1021/acsami.8b19094
To identify ideal scaffold materials for effective mesenchymal stem cell (MSC)-based bone tissue regeneration, here we develop and characterize a composite nanoparticle hydrogel by combining carboxymethyl chitosan (CMCh) and amorphous calcium phosphate (ACP) (designated as CMCh-ACP hydrogel). ...
Improved Piezoelectric Sensing Performance of P(VDF–TrFE) Nanofibers by Utilizing BTO Nanoparticles and Penetrated Electrodes
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-06 ,DOI:10.1021/acsami.8b19824
fluoride (PVDF) and polyvinylidene fluoride–trifluoroethylene [P(VDF–TrFE)] is lower than that of their ceramic counterparts, various approaches have been employed to improve the piezoelectric output of PVDF-based sensors, such as electrospinning, heat annealing, nanoconfinement, polymer blending, and nanoparticle ...
Large-Area Broadband Near-Perfect Absorption from a Thin Chalcogenide Film Coupled to Gold Nanoparticles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-28 ,DOI:10.1021/acsami.8b21452
The absorber is realized via a one-step self-assembly deposition of 50 nm gold (Au) nanoparticle (NP) clusters onto a 35 nm-thick Ge2Sb2Te5 (GST225) chalcogenide film. An excellent agreement between the measured and theoretically simulated absorptance was found. ...
Electronic States and Transport Phenomena of Pt Nanoparticle Catalysts Supported on Nb-Doped SnO2 for Polymer Electrolyte Fuel Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-16 ,DOI:10.1021/acsami.9b11119
Semiconducting oxide nanoparticles are strongly influenced by surface-adsorbed molecules and tend to generate an insulating depletion layer. The interface between a noble metal and a semiconducting oxide constructs a Schottky barrier, interrupting the electron transport. In the case of a Pt catalyst supported on the semiconducting oxide Nb-doped SnO2 with a fused-aggregate network structure (Pt/Nb-SnO2) for polymer electrolyte fuel cells, the electronic conductivity increased abruptly with increasing Pt loading, going from 10–4 to 10–2 S cm–1. The Pt X-ray photoemission spectroscopy (XPS) spectra at low Pt loading amount exhibited higher binding energy than that of pristine Pt metal. The peak shift for the Pt XPS spectra was larger than that of the Pt hard X-ray photoemission spectroscopy (HAXPES) spectra. For all of the spectra, the peaks approached the binding energy of pristine Pt metal with increasing Pt loading. The Sn XPS spectral peak proved the existence of Sn metal with increasing Pt loading, and the peak intensity was larger than that for HAXPES. These spectroscopic results, together with the scanning transmission electron microscopy with energy dispersive X-ray spectroscopy (STEM-EDX) spectra, proved that a PtSn alloy was deposited at the interface between Pt and Nb-SnO2 as a result of the sintering procedure under dilute hydrogen atmosphere. Both Nb spectra indicated that the oxidation state of Nb was +5 and thus that the Nb cation acts as an n-type dopant of SnO2. We conclude that the PtSn alloy at the interface between Pt and Nb-SnO2 relieved the effect of the Schottky barrier, enhanced the carrier donation from Pt to Nb-SnO2, and improved the electronic transport phenomena of Pt/Nb-SnO2. ...
Carboxymethyl Chitosan Modified Carbon Nanoparticle for Controlled Emamectin Benzoate Delivery: Improved Solubility, pH-Responsive Release, and Sustainable Pest Control
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-05 ,DOI:10.1021/acsami.9b12564
Environmentally friendly pesticide delivery systems have drawn extensive attention in recent years, and they show great promise in sustainable development of agriculture. We herein report a multifunctional nanoplatform, carboxymethyl chitosan modified carbon nanoparticles (CMC@CNP), as the carrier for emamectin benzoate (EB, a widely used insecticide), and investigate its sustainable antipest activity. EB was loaded on CMC@CNP nanocarrier via simple physisorption process, with a high loading ratio of 55.56%. The EB@CMC@CNP nanoformulation showed improved solubility and dispersion stability in aqueous solution, which is of vital importance to its practical application. Different from free EB, EB@CMC@CNP exhibited pH-responsive controlled release performance, leading to sustained and steady EB release and prolonged persistence time. In addition, the significantly enhanced anti-UV property of EB@CMC@CNP further ensured its antipest activity. Therefore, EB@CMC@CNP exhibited superior pest control performance than free EB. In consideration of its low cost, easy preparation, free of organic solution, and enhanced bioactivity, we expect, CMC@CNP will have a brilliant future in pest control and green agriculture. ...
Wrapping AgCl Nanostructures with Trimetallic Nanomeshes for Plasmon-Enhanced Catalysis and in Situ SERS Monitoring of Chemical Reactions
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-30 ,DOI:10.1021/acsami.9b18364
Moreover, their applications as surface-enhanced Raman-scattering (SERS) probes for the in situ monitoring of catalytic reduction in real-time and as single-nanoparticle SERS probes for molecular detection are thoroughly demonstrated. ...
Inducing the Formation of In Situ Li3N-Rich SEI via Nanocomposite Plating of Mg3N2 with Lithium Enables High-Performance 3D Lithium-Metal Batteries
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-24 ,DOI:10.1021/acsami.9b16156
We confirmed that the Mg3N2 nanoparticle dispersed in the ether electrolyte can be easily composite-plated with lithium, resulting in a flat, dense, and dendrite-free lithium deposition layer during the electrodeposition process. ...
Array-Assisted SERS Microfluidic Chips for Highly Sensitive and Multiplex Gas Sensing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-24 ,DOI:10.1021/acsami.9b19358
On the other hand, a composite nanoparticle is fabricated as a SERS probe for reading out the fingerprint spectral data, which consists of metal–organic framework (MOF) materials [Zeolitic Imidazolate framework-8 (ZIF-8)] and [email protected] nanocubes, as well as cysteamine (CA) that serves as the ...
Gold-Decorated M13 I-Forms and S-Forms for Targeted Photothermal Lysis of Bacteria
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-18 ,DOI:10.1021/acsami.9b15682
Despite the closely packed Au nanoparticle layer on the surface the viral scaffolds, electron microscopy confirmed that host receptor affinity was retained. Photothermal bactericidal studies were performed using 532 nm laser irradiation with a variety of powers and exposure times. ...
Selective Accumulation of Galactomannan Amphiphilic Nanomaterials in Pediatric Solid Tumor Xenografts Correlates with GLUT1 Gene Expression
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-10 ,DOI:10.1021/acsami.9b12682
These findings point out the potential of this new type of nanoparticle to target GLUT-1-expressing tumors and selectively deliver anticancer agents. ...
Characterization of Key Bio–Nano Interactions between Organosilica Nanoparticles and Candida albicans
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-13 ,DOI:10.1021/acsami.9b10853
Nanoparticle–cell interactions between silica nanomaterials and mammalian cells have been investigated extensively in the context of drug delivery, diagnostics, and imaging. ...
Highly Efficient Photoelectrochemical Reduction of CO2 at Low Applied Voltage Using 3D Co-Pi/BiVO4/SnO2 Nanosheet Array Photoanodes
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-09 ,DOI:10.1021/acsami.9b08144
Coupled with the Au nanoparticle cathode, the PEC cell exhibited a 90.0% faradaic efficiency for CO2 reduction under a small applied voltage of 1.10 V and saved more than 50% of electric energy compared to the general electrochemical cell. ...
Shielding Effectiveness Study of Barium Hexaferrite-Incorporated, β-Phase-Improved Poly(vinylidene fluoride) Composite Film: A Metamaterial Useful for the Reduction of Electromagnetic Pollution
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-20 ,DOI:10.1021/acsami.9b05122
The present work reports the high electromagnetic interference (EMI) shielding effectiveness of ∼−93.5 dB at 8.63 GHz and −97.6 dB at 8.61 GHz in the X- and Ku-bands for 10 and 20 wt % of barium hexaferrite (BaH) nanoparticle-loaded poly(vinylidene fluoride) (PVDF)-based composite films with a thickness ...
Self-Doping Memristors with Equivalently Synaptic Ion Dynamics for Neuromorphic Computing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-06 ,DOI:10.1021/acsami.9b04901
Experimental results and nanoparticle dynamic simulations both showed that Ag atoms from double sources could mimic Ca2+ dynamics in the pre- and post-synaptic terminals under stimuli. ...
Understanding the Static Interfacial Polymer Layer by Exploring the Dispersion States of Nanocomposites
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-01 ,DOI:10.1021/acsami.9b04553
The thickness and density of the static layer are particularly difficult to assess experimentally due to superimposing nanoparticle interactions. ...
Light-Enhanced O2-Evolving Nanoparticles Boost Photodynamic Therapy To Elicit Antitumor Immunity
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-26 ,DOI:10.1021/acsami.9b03541
Our work demonstrates that ultrasmall Cu2–xSe nanoparticle-based nanoplatform offers a promising way to prevent cancer metastasis via immunogenic effects through its excellent PDT performance. ...
Codelivery of Plasmid and Curcumin with Mesoporous Silica Nanoparticles for Promoting Neurite Outgrowth
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-19 ,DOI:10.1021/acsami.9b02797
In this study, we developed a mesoporous silica nanoparticle (MSN)-based approach for neurodegenerative therapy. ...
Electrochemically Activated Nickel–Carbon Composite as Ultrastable Cathodes for Rechargeable Nickel–Zinc Batteries
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-12 ,DOI:10.1021/acsami.9b04006
In this context, we develop a new kind of porous electrochemically activated Ni nanoparticle/nitrogen-doped carbon (Ni/NC) composite material as ultrastable cathodes for advanced aqueous rechargeable nickel–zinc batteries. ...
Highly Conductive Paper/Textile Electrodes Using Ligand Exchange Reaction-Induced in Situ Metallic Fusion
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-18 ,DOI:10.1021/acsami.8b21445
Here, we report that metal nanoparticle (NP)-based paper/textile electrodes with bulk metallic conductivity can be prepared via organic linker-modulated ligand exchange reaction and in situ room-temperature metallic fusion without additional chemical or thermal treatments. ...
High Biocompatible ZIF-8 Coated by ZrO2 for Chemo-microwave Thermal Tumor Synergistic Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-06 ,DOI:10.1021/acsami.8b22177
The survival rate of cells and mice in the ZIF-8@ZrO2 nanocomposite group is significantly increased compared with the undecorated ZIF-8 nanoparticle group. Doxorubicin (DOX) as a chemotherapeutic drug is deposited during the ZIF-8 growth by a facile one-pot method. ...
Intracellular Dynamic Disentangling of Doxorubicin Release from Luminescent Nanogold Carriers by Fluorescence Lifetime Imaging Microscopy (FLIM) under Two-Photon Excitation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-13 ,DOI:10.1021/acsami.8b21269
We present here the assessment of the intracellular kinetics of doxorubicin (DOX) and gold nanoparticle(AuNP) carriers by mapping simultaneously fluorescence and photoluminescence signals by fluorescence lifetime imaging microscopy under two-photon excitation (TPE-FLIM). ...
Ultrasensitive and Stable Plasmonic Surface-Enhanced Raman Scattering Substrates Covered with Atomically Thin Monolayers: Effect of the Insulating Property
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-01 ,DOI:10.1021/acsami.8b17847
We demonstrated the effects of monolayer graphene and hexagonal boron nitride (h-BN) on the stability and detection performance of two types of substrates in surface-enhanced Raman scattering (SERS): a two-dimensional (2D) monolayer/Ag nanoparticle (NP) substrate and a Au NP/2D monolayer/Ag NP substrate ...
Paper-Supported Self-Powered System Based on a Glucose/O2 Biofuel Cell for Visual MicroRNA-21 Sensing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-25 ,DOI:10.1021/acsami.8b20034
The BFC device utilized gold nanoparticle-modified paper fibers as the electrode to wire glucose oxidase (GOx) and bilirubin oxidase for the fabrication of bioanodes and biocathodes. ...
Dual-Modified Novel Biomimetic Nanocarriers Improve Targeting and Therapeutic Efficacy in Glioma
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-04 ,DOI:10.1021/acsami.8b18664
Herein, we designed a red blood cell membrane-coated solid lipid nanoparticle (RBCSLN)-based nanocarrier dual-modified with T7 and NGR peptide (T7/NGR-RBCSLNs) to accomplish these objectives. ...
Light-Guided Surface Plasmonic Bubble Movement via Contact Line De-Pinning by In-Situ Deposited Plasmonic Nanoparticle Heating
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-10 ,DOI:10.1021/acsami.9b16067
Precise spatiotemporal control of surface bubble movement can benefit a wide range of applications like high-throughput drug screening, combinatorial material development, microfluidic logic, colloidal and molecular assembly, and so forth. In this work, we demonstrate that surface bubbles on a solid surface are directed by a laser to move at high speeds (>1.8 mm/s), and we elucidate the mechanism to be the depinning of the three-phase contact line (TPCL) by rapid plasmonic heating of nanoparticles (NPs) deposited in situ during bubble movement. On the basis of our observations, we deduce a stick–slip mechanism based on asymmetric fore–aft plasmonic heating: local evaporation at the front TPCL due to plasmonic heating depins and extends the front TPCL, followed by the advancement of the trailing TPCL to resume a spherical bubble shape to minimize surface energy. The continuous TPCL drying during bubble movement also enables well-defined contact line deposition of NP clusters along the moving path. Our finding is beneficial to various microfluidics and pattern writing applications. ...
Detection of Phenylketonuria Markers Using a ZIF-67 Encapsulated PtPd Alloy Nanoparticle (PtPd@ZIF-67)-Based Disposable Electrochemical Microsensor
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-28 ,DOI:10.1021/acsami.9b05431
Phenylketonuria (PKU) is a common disease in congenital disorder of amino acid metabolism, which can lead to intellectual disability, seizures, behavioral problems, and mental disorders. We report herein a facile method to screen for PKU by the measurements of its metabolites (markers). In this work, a disposable electrochemical microsensor modified with a ZIF (zeolitic imidazolate framework)-based nanocomposite is constructed, in which ZIF-67 crystals are encapsulated with PtPd alloy nanoparticles (NPs) forming the nanocomposite (PtPd@ZIF-67). According to electrochemical measurements, the PtPd@ZIF-67-modified microsensor shows good responses and selectivity to phenylpyruvic acid and phenylacetic acid, while almost no response toward other amino acid analogues is observed. Here, a new sensing mechanism based on the acylation reaction between the imidazole linker in ZIF-67 and carboxyl in PKU markers has been proposed and verified through the Fourier-transform infrared spectroscopy study. Moreover, the encapsulated PtPd NPs elevate the electron transfer capability of the PtPd@ZIF-67-modified microsensor and further improve the electrochemical sensing performance. Finally, we demonstrate that the developed PtPd@ZIF-67-modified microsensor has the possibility to sensing of PKU markers with high response and good specificity and may be extended to exploit the point-of-care rapid PKU screening. ...
Decoration of Porous Silicon with Gold Nanoparticles via Layer-by-Layer Nanoassembly for Interferometric and Hybrid Photonic/Plasmonic (Bio)sensing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-08 ,DOI:10.1021/acsami.9b15737
Gold nanoparticle layers (AuNPLs) enable the coupling of morphological, optical, and electrical properties of gold nanoparticles (AuNPs) with tailored and specific surface topography, making them exploitable in many bioapplications (e.g., biosensing, drug delivery, and photothermal therapy). ...
Phospholipid-Coated Hydrophobic Mesoporous Silica Nanoparticles Enhance Thrombectomy by High-Intensity Focused Ultrasound with Low Production of Embolism-Inducing Clot Debris
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-26 ,DOI:10.1021/acsami.9b11095
Here we report the efficacy of a nanoparticle-assisted high-intensity focused ultrasound (HIFU) treatment that selectively destroys blood clots while minimizing generation of microparticles, or microemboli, that can cause further complications postsurgery. ...
Hybrid Azo-fluorophore Organic Nanoparticles as Emissive Turn-on Probes for Cellular Endocytosis
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-28 ,DOI:10.1021/acsami.9b12989
Thorough biological examinations involving cancer cells prove a receptor-independent endocytosis pathway, leading to progressive cell lighting upon nanoparticle accumulation in the late endosomal/lysosomal compartments. ...
Ratiometric Imaging of the in Situ pH Distribution of Biofilms by Use of Fluorescent Mesoporous Silica Nanosensors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-28 ,DOI:10.1021/acsami.9b09978
The dye-MSNs were able to fully penetrate the biofilm matrix and allowed a quantitative ratiometric analysis of pH gradients and distribution throughout the biofilm, which was independent of the nanoparticle concentration. ...
Preparation of Dual-Template Epitope Imprinted Polymers for Targeted Fluorescence Imaging and Targeted Drug Delivery to Pancreatic Cancer BxPC-3 Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-20 ,DOI:10.1021/acsami.9b11533
To address this issue, a dual-template molecularly imprinted polymer nanoparticle used for targeted diagnosis and drug delivery for pancreatic cancer BxPC-3 cells (FH-MIPNPs) was prepared. ...
Nonlinear Nanomechanical Mass Spectrometry at the Single-Nanoparticle Level
Nano Letters (IF 12.279) Pub Date : 2019-05-31 ,DOI:10.1021/acs.nanolett.9b00546
Once the feasibility of the technique is established, we have obtained the mass spectrum of a 20 nm gold nanoparticle sample by individually recording about 500 single-particle events using two modes working sequentially in the nonlinear regime. ...
High-Contrast Imaging of Nanodiamonds in Cells by Energy Filtered and Correlative Light-Electron Microscopy: Toward a Quantitative Nanoparticle-Cell Analysis
Nano Letters (IF 12.279) Pub Date : 2019-03-04 ,DOI:10.1021/acs.nanolett.9b00752
Their biocompatibility, exceptional chemical and consistent photostability renders them particularly attractive for correlative light-electron microscopy studies providing unique insights into nanoparticle-cell interactions. ...
Scatter Enhanced Phase Contrast Microscopy for Discriminating Mechanisms of Active Nanoparticle Transport in Living Cells
Nano Letters (IF 12.279) Pub Date : 2019-01-23 ,DOI:10.1021/acs.nanolett.8b03903
Finally, we combine this technique with microcontact printing to normalize transport dynamics across multiple cells, allowing for a careful study of ensemble TiO2 nanoparticle uptake. ...
Exceptional Two-Photon Absorption in Alkynylruthenium–Gold Nanoparticle Hybrids
Nano Letters (IF 12.279) Pub Date : 2019-01-16 ,DOI:10.1021/acs.nanolett.8b03825
The ca. 2.5 nm diameter (by transmission electron microscopy) trithienylbenzene-cored gold nanoparticlehybrids are significantly less absorbent than classical Brust nanoparticles stabilized by 1-dodecanethiol; with femtosecond pulsed radiation, they exhibit exceptionally strong saturable absorption ...
Tuning Nanoparticle Electrodynamics by an Optical-Matter-Based Laser Beam Shaper
Nano Letters (IF 12.279) Pub Date : 2019-04-29 ,DOI:10.1021/acs.nanolett.9b01090
Spatially modulated optical fields provide the perspective of tuning nanoparticle (NP) dynamics in a colloidal suspension. ...
Micelle-Assisted Formation of Nanoparticle Superlattices and Thermally Reversible Symmetry Transitions
Nano Letters (IF 12.279) Pub Date : 2019-01-25 ,DOI:10.1021/acs.nanolett.8b04817
Nanoparticle superlattices (NPSLs) are of great interest as materials with designed emerging properties depending on the lattice symmetry as well as composition. ...
Biodegradable, pH-Sensitive Hollow Mesoporous Organosilica Nanoparticle (HMON) with Controlled Release of Pirfenidone and Ultrasound-Target-Microbubble-Destruction (UTMD) for Pancreatic Cancer Treatment.
Theranostics (IF 8.063) Pub Date : 2019-09-20 ,DOI:10.7150/thno.36135
By varying pH producing a mildly acidic environment to emulate tumor cells, results in cleavage of the acetal bond between HMON nanoparticle and gating molecular, gemcitabine (Gem), enabling its controlled release. ...
Nanoparticle-enabled phase control for arc welding of unweldable aluminum alloy 7075.
Nature Communications (IF 11.878) Pub Date : 2019-Jan-0 ,DOI:10.1038/s41467-018-07989-y
Here, we show that AA7075 can be safely arc welded without hot cracks by introducing nanoparticle-enabled phase control during welding. ...
NIR-light-mediated spatially selective triggering of anti-tumor immunity via upconversion nanoparticle-based immunodevices
Nature Communications (IF 11.878) Pub Date : 2019-06-28 ,DOI:10.1038/s41467-019-10847-0
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window. ...
Recent advances and challenges of repurposing nanoparticle-based drug delivery systems to enhance cancer immunotherapy
Theranostics (IF 8.063) Pub Date : 2019-10-16 ,DOI:10.7150/thno.38425
Therefore, nanoparticle (NP)-based drug delivery has been used to not only increase the efficacy of immunotherapeutic agents, but it also significantly reduces the toxicity. ...
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
Nature Communications (IF 11.878) Pub Date : 2019-09-19 ,DOI:10.1038/s41467-019-12080-1
Immunization studies show that the NPs are particularly efficacious as priming immunogens, improve the quality of the Ab response over a conventional one-component nanoparticle system, and are most effective when SOSIP trimers with an apex-proximate neutralizing epitope are displayed. ...
Dynamically Reversible Iron Oxide Nanoparticle Assemblies for Targeted Amplification of T1-Weighted Magnetic Resonance Imaging of Tumors
Nano Letters (IF 12.279) Pub Date : 2019-02-14 ,DOI:10.1021/acs.nanolett.8b04411
Here, we report pH-sensitive iron oxide nanoparticle assemblies (IONAs) that are cross-linked by small-molecular aldehyde derivative ligands. ...
Precise Fabrication of De Novo Nanoparticle Lattices on Dynamic 2D Protein Crystalline Lattices
Nano Letters (IF 12.279) Pub Date : 2019-12-30 ,DOI:10.1021/acs.nanolett.9b04574
Despite the prominent achievements in the field, the desire of designing de novo protein–nanoparticle(NP) complexes and constructing dynamic NP systems remains highly challenging. ...
Stepwise Ligand-induced Self-assembly for Facile Fabrication of Nanodiamond–Gold Nanoparticle Dimers via Noncovalent Biotin–Streptavidin Interactions
Nano Letters (IF 12.279) Pub Date : 2019-02-22 ,DOI:10.1021/acs.nanolett.9b00113
Nanodiamond–gold nanoparticle (ND-AuNP) dimers constitute a potent tool for controlled thermal heating of biological systems on the nanoscale, by combining a local light-induced heat source with a sensitive local thermometer. ...
Cold-Responsive Nanoparticle Enables Intracellular Delivery and Rapid Release of Trehalose for Organic-Solvent-Free Cryopreservation
Nano Letters (IF 12.279) Pub Date : 2019-11-12 ,DOI:10.1021/acs.nanolett.9b04109
This cold-responsive nanoparticle may greatly facilitate the use of trehalose as a nontoxic cryoprotectant for banking cells and tissues to meet their high demand by modern cell-based medicine. ...
The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
Nature Nanotechnology (IF 33.407) Pub Date : 2019-12-04 ,DOI:10.1038/s41565-019-0591-y
The regulatory approval of Onpattro, a lipid nanoparticle-based short interfering RNA drug for the treatment of polyneuropathies induced by hereditary transthyretin amyloidosis, paves the way for clinical development of many nucleic acid-based therapies enabled by nanoparticle delivery. ...
Conversion of Metal–Organic Cage to Ligand-Free Ultrasmall Noble Metal Nanocluster Catalysts Confined within Mesoporous Silica Nanoparticle Supports
Nano Letters (IF 12.279) Pub Date : 2019-02-08 ,DOI:10.1021/acs.nanolett.8b04121
In this work, we present a novel strategy for the controlled synthesis of ligand-free UNMN nanocatalysts based on in situ reduction of a palladium-based (Pd-based) metal–organic cage (MOC) confined within monosized, thiol-modified mesoporous silica nanoparticle (MSN) supports. ...
Heuristics for the Optimal Presentation of Bioactive Peptides on Polypeptide Micelles
Nano Letters (IF 12.279) Pub Date : 2019-10-29 ,DOI:10.1021/acs.nanolett.9b03141
To address this need, we developed a multivalent nanoparticle platform to study the impact of nanoparticle surface hydrophilicity and charge on peptide targeting and internalization by tumor cells. ...
Targeted Drug Delivery and Image-Guided Therapy of Heterogeneous Ovarian Cancer Using HER2-Targeted Theranostic Nanoparticles
Theranostics (IF 8.063) Pub Date : 2019-01-24 ,DOI:10.7150/thno.29964
Nanoparticle retention in the small residual tumors, nevertheless, produced optical signals for detection by spectroscopic imaging. ...
Fe3O4@TiO2-Laden Neutrophils Activate Innate Immunity via Photosensitive Reactive Oxygen Species Release
Nano Letters (IF 12.279) Pub Date : 2019-12-02 ,DOI:10.1021/acs.nanolett.9b03777
We prepared the photocatalytic nanoparticle-laden neutrophils in vivo through neutrophil phagocytosis. ...
In-situ electron microscopy mapping of an order-disorder transition in a superionic conductor
Nature Communications (IF 11.878) Pub Date : 2019-04-03 ,DOI:10.1038/s41467-019-09502-5
The spatiotemporal insights gained here advance understanding of order-disorder transitions, ionic structure and transport, and the role of nanoparticle surfaces in phase transitions. ...
Ultrasonic Nebulization for TEM Sample Preparation on Single-Layer Graphene Grids
Nano Letters (IF 12.279) Pub Date : 2019-02-12 ,DOI:10.1021/acs.nanolett.8b05117
Additionally, because ultrasonic nebulization produces uniform droplets, nanoparticles deposited by spray-coating occur on the TEM grid in clusters, whose size is dependent on the concentration of the nanoparticle dispersion, which may allow the concentration of nanoparticle dispersions to be estimated ...
Codelivery Nanosystem Targeting the Deep Microenvironment of Pancreatic Cancer
Nano Letters (IF 12.279) Pub Date : 2019-05-14 ,DOI:10.1021/acs.nanolett.9b00374
The designed nanoparticle disrupted the central stroma while preserving the external stroma, thereby promoting the antitumor effectiveness of chemotherapeutics. ...
Super-Resolution Optical Lithography with DNA
Nano Letters (IF 12.279) Pub Date : 2019-08-21 ,DOI:10.1021/acs.nanolett.9b01873
Furthermore, no optical technique is currently available to construct nanoparticle assemblies with a precisely designed shape and internal structure at a resolution of a few tens of nanometers (nm). ...
Pointing in the Right Direction: Controlling the Orientation of Proteins on Nanoparticles Improves Targeting Efficiency
Nano Letters (IF 12.279) Pub Date : 2019-02-21 ,DOI:10.1021/acs.nanolett.8b04916
The azPhe modified sdAb can be tethered to the nanoparticle in a specific orientation using a bioorthogonal click reaction with a strained cyclooctyne. ...
Tuning the Potential Energy Landscape to Suppress Ostwald Ripening in Surface-Supported Catalyst Systems
Nano Letters (IF 12.279) Pub Date : 2019-11-06 ,DOI:10.1021/acs.nanolett.9b02237
Zeolites with the same structure (ZSM-5) but different concentrations of aluminum doped into the matrix were observed to yield systematic differences in supported nanoparticle size distributions. ...
FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels
Nature Nanotechnology (IF 33.407) Pub Date : 2019-03-25 ,DOI:10.1038/s41565-019-0406-1
We have found that ferumoxytol (Feraheme), an FDA-approved iron oxide nanoparticle for iron deficiency treatment, demonstrates an anti-leukaemia effect in vitro and in vivo. ...
Measuring Nanoparticle Polarizability Using Fluorescence Microscopy
Nano Letters (IF 12.279) Pub Date : 2019-07-22 ,DOI:10.1021/acs.nanolett.9b02402
Using a novel method developed to quantify the polarizability of photoluminescent nanoparticles in water, we present experimental observations of the extraordinary polarizability exhibited by nanoparticles of commensurate size with the Debye screening length, confirming previously reported theory. Semiconductor quantum dots (QDs) are ideal model nanoparticles to demonstrate this assay, due to their tunable size and bright photoluminescence. This assay is based upon microfluidic chambers with microelectrodes that generate trapping potentials that are weaker than thermal energy. By comparing the local electric field strength and variations in QD concentration, their polarizability was computed and found to agree with estimates based upon the hydrodynamic diameter found using light scattering. Strikingly, the polarizability of the nanoparticles increased 30-fold in low salt conditions compared to high salt conditions due to the increased thickness of the Debye layer relative to the particle radius. In addition to providing evidence that corroborates theoretical work studying direct solutions to the Poisson–Nernst–Planck equations, these observations provide an explanation for the previously observed conductivity dependence of biomolecule polarizability. As the polarizability of nanoparticles is of high importance to the electrically directed assembly of particles, as well as their interactions with other materials in complex environments, we anticipate that these results will be highly relevant to ongoing efforts in materials by design and nanomedicine. ...
SERS discrimination of single DNA bases in single oligonucleotides by electro-plasmonic trapping
Nature Communications (IF 11.878) Pub Date : 2019-11-22 ,DOI:10.1038/s41467-019-13242-x
By directly adsorbing molecules onto a gold nanoparticle and then trapping the single nanoparticle in a plasmonic nanohole up to several minutes, we demonstrate single-molecule SERS detection of all four DNA bases as well as discrimination of single nucleobases in a single oligonucleotide. ...
Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy
Theranostics (IF 8.063) Pub Date : 2019-04-13 ,DOI:10.7150/thno.34740
However, the reverse structure of MOF-integrated inorganic nanoparticle (MOF@NP) with multifunction has rarely been reported. ...
Overall electrochemical splitting of water at the heterogeneous interface of nickel and iron oxide
Nature Communications (IF 11.878) Pub Date : 2019-12-06 ,DOI:10.1038/s41467-019-13415-8
Density functional theory calculations reveal that the hydrogen evolution reaction catalytic activity of the nanoparticle is induced by the strong electronic coupling effect between the iron oxide and the nickel at the interface. ...
Upconversion superburst with sub-2 μs lifetime
Nature Nanotechnology (IF 33.407) Pub Date : 2019-10-28 ,DOI:10.1038/s41565-019-0560-5
Here, we report the direct observation of upconversion superburst with directional, fast and ultrabright luminescence by coupling gap plasmon modes to nanoparticle emitters. ...
Intracellularly Generated Immunological Gold Nanoparticles for Combinatorial Photothermal Therapy and Immunotherapy against Tumor
Nano Letters (IF 12.279) Pub Date : 2019-08-12 ,DOI:10.1021/acs.nanolett.9b02903
Melanoma B16F10 cells were employed to generate AuNPs first and then shed nanoparticle trapped vesicles to extracellular environment with retained tumor antigens (AuNP@B16F10). ...
Iron Oxide Nanoflowers @ CuS Hybrids for Cancer Tri-Therapy: Interplay of Photothermal Therapy, Magnetic Hyperthermia and Photodynamic Therapy
Theranostics (IF 8.063) Pub Date : 2019-02-12 ,DOI:10.7150/thno.30238
Conclusions: Altogether, the obtained data evidence the successful synthesis of a unique tri-therapeutic nanoparticle featuring highly relevant assets for clinical translation such as reduced nanoparticleadministered dose, reduced laser power exposure, reduced magnetic field frequency, and the possibility ...
Nanoparticle-Induced Anomalous Hall Effect in Graphene
Nano Letters (IF 12.279) Pub Date : 2019-09-17 ,DOI:10.1021/acs.nanolett.9b02643
Schemes for introducing magnetic properties into graphene are of fundamental interest and could enable the development of electrically controlled magnetic devices, thereby extending graphene’s applications from conventional electronics to spintronics. Proximity-induced ferromagnetism (PIFM) has been reported for graphene coupled to adjacent ferromagnetic insulators (FMIs). PIFM from an FMI preserves graphene’s high carrier mobility and does not introduce a parallel current path. However, few FMIs other than yttrium–iron–garnet are suitable for practical applications due to difficulties in their growth and deposition and to their typically low Curie temperatures. Furthermore, it is difficult to obtain a high-quality FMI/graphene interface by graphene transfer methods, which are essential for obtaining the required interfacial exchange coupling. Here, we report the observation of the anomalous Hall effect (AHE) in graphene proximity coupled to an array of magnetic nanoparticles. This observation of AHE in graphene in proximity to a discontinuous magnetic structure opens the door to realizing magnetic properties in graphene from a greatly expanded range of materials and offers new possibilities for realizing patterned spintronic devices and circuitry. ...
Engineering Nanoparticles to Reprogram the Tumor Immune Microenvironment for Improved Cancer Immunotherapy
Theranostics (IF 8.063) Pub Date : 2019-10-17 ,DOI:10.7150/thno.37568
Tremendous research interest exists in developing nanoparticle-based approaches to modulate antitumor immune responses. The increasing use of immunotherapies in the clinic requires robust programming of immune cells to boost anti-tumor immunity. ...
Surface-kinetics mediated mesoporous multipods for enhanced bacterial adhesion and inhibition
Nature Communications (IF 11.878) Pub Date : 2019-09-26 ,DOI:10.1038/s41467-019-12378-0
Despite the importance of nanoparticle’s multipods topology in multivalent-interactions enhanced nano-bio interactions, the precise manipulation of multipods surface topological structures is still a great challenge. ...
Electrochemical Synthesis of Individual Core@Shell and Hollow Ag/Ag2S Nanoparticles
Nano Letters (IF 12.279) Pub Date : 2019-07-26 ,DOI:10.1021/acs.nanolett.9b02144
A single continuous current transient is observed for each Ag nanoparticle reacted. ...
Immunoregulation of macrophages by dynamic ligand presentation via ligand–cation coordination
Nature Communications (IF 11.878) Pub Date : 2019-04-12 ,DOI:10.1038/s41467-019-09733-6
Herein, we employ bisphosphonate (BP)-coated gold nanoparticle template (BNP) to direct the swift and convertible formation of Mg2+-functional Mg2+-BP nanoparticle (NP) on the BP-AuNP surface via reversible Mg2+-BP coordination, thus producing (Mg2+-BP)-Au dimer (MgBNP). ...
Cuboidal tethered cyclodextrin frameworks tailored for hemostasis and injured vessel targeting.
Theranostics (IF 8.063) Pub Date : 2019-05-28 ,DOI:10.7150/thno.31159
The cuboidal nanoparticle system provides an innovative delivery platform for the treatment and diagnosis of vascular diseases. ...
Redox-Activated Porphyrin-Based Liposome Remote-Loaded with Indoleamine 2,3-Dioxygenase (IDO) Inhibitor for Synergistic Photoimmunotherapy through Induction of Immunogenic Cell Death and Blockage of IDO Pathway
Nano Letters (IF 12.279) Pub Date : 2019-09-24 ,DOI:10.1021/acs.nanolett.9b02306
The nanoparticle exhibited prolonged blood circulation and enhanced tumor accumulation in the 4T1 tumor-bearing mice after intravenous injection. ...
Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy
Nano Letters (IF 12.279) Pub Date : 2019-04-05 ,DOI:10.1021/acs.nanolett.8b04296
Herein, we report a proof-of-concept of RNAi nanoparticle-mediated therapeutic reversion of tumor acidity to restore the antitumor functions of T cells and potentiate the checkpoint blockade therapy. ...
Reshaping the Second-Order Polar Response of Hybrid Metal–Dielectric Nanodimers
Nano Letters (IF 12.279) Pub Date : 2019-01-10 ,DOI:10.1021/acs.nanolett.8b04089
The overlap of the localized surface plasmon resonant dipole mode of the gold nanoparticle with the dipole and higher-order Mie resonant modes in the BTO nanoparticle lead to the formation of hybridized modes in the visible spectral range. ...
High-speed imaging of surface-enhanced Raman scattering fluctuations from individual nanoparticles
Nature Nanotechnology (IF 33.407) Pub Date : 2019-09-16 ,DOI:10.1038/s41565-019-0535-6
The images reveal short ~10 µs scattering events localized in various regions on a single nanoparticle. Remarkably, even a fully functionalized nanoparticle was ‘dark’ more than 98% of the time. ...
Iron and sulfide nanoparticle formation and transport in nascent hydrothermal vent plumes
Nature Communications (IF 11.878) Pub Date : 2019-04-08 ,DOI:10.1038/s41467-019-09580-5
Deep-sea hydrothermal vents are a significant source of dissolved metals to the global oceans, producing midwater plumes enriched in metals that are transported thousands of kilometers from the vent source. Particle precipitation upon emission of hydrothermal fluids controls metal speciation and the magnitude of metal export. Here, we document metal sulfide particles, including pyrite nanoparticles, within the first meter of buoyant plumes from three high-temperature vents at the East Pacific Rise. We observe a zone of particle settling 10–20 cm from the orifice, indicated by stable sulfur isotopes; however, we also demonstrate that nanoparticulate pyrite (FeS2) is not removed from the plume and can account for over half of the filtered Fe (≤0.2 µm) up to one meter from the vent orifice. The persistence of nanoparticulate pyrite demonstrates that it is an important mechanism for near-vent Fe stabilisation and highlights the potential role of nanoparticles in element transport. ...
Controlling the Dynamics and Optical Binding of Nanoparticle Homodimers with Transverse Phase Gradients
Nano Letters (IF 12.279) Pub Date : 2019-01-09 ,DOI:10.1021/acs.nanolett.8b04134
While transverse phase gradients enable studies of driven nonequilibrium phenomena in optical trapping, the behavior of electrodynamically interacting particles in a transverse phase gradient has not been explored in detail. In this Letter we study electrodynamically interacting pairs of identical nanoparticles (homodimers) in transverse phase gradients. We establish that the net driving force on homodimers is modulated by a separation-dependent interference effect for small phase gradients. By contrast, large phase gradients break the symmetry of the interaction between particles and profoundly change the electrodynamic interparticle energy landscape. Our findings are particularly important for understanding multiparticle dynamics during the self-assembly and rearrangement of optical matter. ...
Modeling Superlattices of Dipolar and Polarizable Semiconducting Nanoparticles
Nano Letters (IF 12.279) Pub Date : 2019-05-30 ,DOI:10.1021/acs.nanolett.9b01142
We present an analytical model to describe the stability of arbitrary semiconducting nanoparticle (NP) superlattices as a function of the dipole and polarizability of their constituents. ...
Holey Graphene Metal Nanoparticle Composites via Crystalline Polymer Templated Etching
Nano Letters (IF 12.279) Pub Date : 2019-04-15 ,DOI:10.1021/acs.nanolett.8b04755
While graphene has sparked enormous research interest since its isolation in 2004, there has also been an interest in developing graphene composite materials that leverage graphene’s extraordinary physical properties toward new technologies. Oxidative analogues such as graphene oxide and reduced graphene oxide retain many of the same properties of graphene. While these materials contain many functional moieties, defect formation through current oxidation methods is random which, despite reductive treatments, can never fully recover the properties of the starting material. In the interest of bridging the divide between these two sets of materials for composite materials, here we show a methodology utilizing 2-D covalent organic frameworks as templates for hole formation in graphene through plasma etching. The holes formed act as edge-only chemical handles while retaining a contiguous sp2 structure. Holey graphene structures generated act as autoreduction sites for small noble metal nanoparticles which return many of graphene’s original electrical properties that can be used for functional composites. Composite materials here show 103 enhancement of the Raman signal of the underlying holey graphene as well as excellent calculated limits of detection in gas sensing of H2S (3 ppb) and H2 (10 ppm). ...
Kidney-targeted rhein-loaded liponanoparticles for diabetic nephropathy therapy via size control and enhancement of renal cellular uptake.
Theranostics (IF 8.063) Pub Date : 2019-09-20 ,DOI:10.7150/thno.37538
The optimization of nanoparticle size for passing through glomerular filtration membrane, inefficient renal cellular uptake and rapid urinary excretion of nanoparticles are the major obstacles for renal disease treatment via a nanoparticle delivery system. ...
Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles
Theranostics (IF 8.063) Pub Date : 2019-08-21 ,DOI:10.7150/thno.34429
Keywords: chemoimmunotherapy, immune modulation, immune adjuvants, multi-drug nanoparticle, theragnostic. ...
Anomalously Large Spectral Shifts near the Quantum Tunnelling Limit in Plasmonic Rulers with Subatomic Resolution
Nano Letters (IF 12.279) Pub Date : 2019-02-19 ,DOI:10.1021/acs.nanolett.9b00199
We explore this behavior in the subnanometer regime using self-assembled monolayers of bis-phthalocyanine molecules in a nanoparticle-on-mirror (NPoM) construct. ...
Self-Delivery Micellar Nanoparticles Prevent Premetastatic Niche Formation by Interfering with the Early Recruitment and Vascular Destruction of Granulocytic Myeloid-Derived Suppressor Cells
Nano Letters (IF 12.279) Pub Date : 2019-12-11 ,DOI:10.1021/acs.nanolett.9b03883
Here, a micellar hypotoxic low molecular weight heparin-tocopherol succinate nanoparticle (LMWH-TOS nanoparticle, LT NP) was established and investigated for its influence on PMN formation in this study. ...
Decoding Biomineralization: Interaction of a Mad10-Derived Peptide with Magnetite Thin Films
Nano Letters (IF 12.279) Pub Date : 2019-10-07 ,DOI:10.1021/acs.nanolett.9b03560
Most interestingly, nanoparticle morphologies have been discovered that defy crystallographic rules (e.g., in the species Desulfamplus magnetovallimortis strain BW-1). ...
Nanoparticle Mobility over a Surface as a Probe for Weak Transient Disordered Peptide–Peptide Interactions
Nano Letters (IF 12.279) Pub Date : 2019-09-03 ,DOI:10.1021/acs.nanolett.9b02764
Weak interactions form the core basis of a vast number of biological processes, in particular, those involving intrinsically disordered proteins. Here, we establish a new technique capable of probing these weak interactions between synthetic unfolded polypeptides using a convenient yet efficient, quantitative method based on single particle tracking of peptide-coated gold nanoparticles over peptide-coated surfaces. We demonstrate that our technique is sensitive enough to observe the influence of a single amino acid mutation on the transient peptide–peptide interactions. Furthermore, the effects of buffer salinity, which are expected to alter weak electrostatic interactions, are also readily detected and examined in detail. The method presented here has the potential to evaluate, in a high-throughput manner, weak interactions for a wide range of disordered proteins, polypeptides, and other biomolecules. ...
Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy
Nature Communications (IF 11.878) Pub Date : 2019-08-22 ,DOI:10.1038/s41467-019-11762-0
Alzheimer’s disease (AD) is the most prevalent form of neurodegenerative disorders, yet no major breakthroughs have been made in AD human trials and the disease remains a paramount challenge and a stigma in medicine. Here we eliminate the toxicity of amyloid beta (Aβ) in a facile, high-throughput zebrafish (Danio rerio) model using casein coated-gold nanoparticles (βCas AuNPs). βCas AuNPs in systemic circulation translocate across the blood brain barrier of zebrafish larvae and sequester intracerebral Aβ42 and its elicited toxicity in a nonspecific, chaperone-like manner. This is evidenced by behavioral pathology, reactive oxygen species and neuronal dysfunction biomarkers assays, complemented by brain histology and inductively coupled plasma-mass spectroscopy. We further demonstrate the capacity of βCas AuNPs in recovering the mobility and cognitive function of adult zebrafish exposed to Aβ. This potent, safe-to-use, and easy-to-apply nanomedicine may find broad use for eradicating toxic amyloid proteins implicated in a range of human diseases. ...
Enhanced photocatalysis and biomolecular sensing with field-activated nanotube-nanoparticle templates
Nature Communications (IF 11.878) Pub Date : 2019-06-07 ,DOI:10.1038/s41467-019-10393-9
The development of new catalysts for oxidation reactions is of central importance for many industrial processes. Plasmonic catalysis involves photoexcitation of templates/chips to drive and enhance oxidation of target molecules. Raman-based sensing of target molecules can also be enhanced by these templates. This provides motivation for the rational design, characterization, and experimental demonstration of effective template nanostructures. In this paper, we report on a template comprising silver nanoparticles on aligned peptide nanotubes, contacted with a microfabricated chip in a dry environment. Efficient plasmonic catalysis for oxidation of molecules such as p-aminothiophenol results from facile trans-template charge transfer, activated and controlled by application of an electric field. Raman detection of biomolecules such as glucose and nucleobases are also dramatically enhanced by the template. A reduced quantum mechanical model is formulated, comprising a minimum description of key components. Calculated nanotube-metal-molecule charge transfer is used to understand the catalytic mechanism and shows this system is well-optimized. ...
Direct Observation of Plasmon Band Formation and Delocalization in Quasi-Infinite Nanoparticle Chains
Nano Letters (IF 12.279) Pub Date : 2019-05-29 ,DOI:10.1021/acs.nanolett.9b01031
Chains of metallic nanoparticles sustain strongly confined surface plasmons with relatively low dielectric losses. To exploit these properties in applications, such as waveguides, the fabrication of long chains of low disorder and a thorough understanding of the plasmon-mode properties, such as dispersion relations, are indispensable. Here, we use a wrinkled template for directed self-assembly to assemble chains of gold nanoparticles. With this up-scalable method, chain lengths from two particles (140 nm) to 20 particles (1500 nm) and beyond can be fabricated. Electron energy-loss spectroscopy supported by boundary element simulations, finite-difference time-domain, and a simplified dipole coupling model reveal the evolution of a band of plasmonic waveguide modes from degenerated single-particle modes in detail. In striking difference from plasmonic rod-like structures, the plasmon band is confined in excitation energy, which allows light manipulations below the diffraction limit. The non-degenerated surface plasmon modes show suppressed radiative losses for efficient energy propagation over a distance of 1500 nm. ...
Guanidinocalix[5]arene for sensitive fluorescence detection and magnetic removal of perfluorinated pollutants
Nature Communications (IF 11.878) Pub Date : 2019-12-17 ,DOI:10.1038/s41467-019-13775-1
Moreover, by co-assembling iron oxide nanoparticle with the amphiphilic guanidinocalix[5]arene, we are able to use simple magnetic absorption and filtration to efficiently remove PFOS and PFOA from contaminated water. ...
Diffusion-Limited Formation of Nonequilibrium Intermetallic Nanophase for Selective Dehydrogenation
Nano Letters (IF 12.279) Pub Date : 2019-06-05 ,DOI:10.1021/acs.nanolett.9b00994
The kinetically limited solid-state reaction is generally applicable to nanoparticle synthesis and could produce materials with desired structures and properties beyond conventional structural limits ...
Spectral Screening of the Energy of Hot Holes over a Particle Plasmon Resonance
Nano Letters (IF 12.279) Pub Date : 2019-02-27 ,DOI:10.1021/acs.nanolett.8b04950
Here an energy screening study was performed by monitoring the aniline electro-polymerization reaction via an illuminated 80 nm gold nanoparticle. Our results show that plasmon excitation reduces the energy required to start the polymerization reaction as much as 0.24 eV. ...
CD137 promotes bone metastasis of breast cancer by enhancing the migration and osteoclast differentiation of monocytes/macrophages
Theranostics (IF 8.063) Pub Date : 2019-05-09 ,DOI:10.7150/thno.29617
Based on these findings, a novel F4/80-targeted liposomal nanoparticle encapsulating the anti-CD137 blocking antibody (NP-αCD137 Ab-F4/80) was synthesized. This nanoparticle could inhibit both bone and lung metastases of 4T1 breast cancer cells with high efficacy in vivo. ...
Time-Resolved Activation of pH Sensing and Imaging in Vivo by a Remotely Controllable DNA Nanomachine
Nano Letters (IF 12.279) Pub Date : 2019-12-30 ,DOI:10.1021/acs.nanolett.9b03471
The nanomachine is designed by rational engineering of the DNA motif with a light-responsive element and further combination with an upconversion nanoparticle that works as a transducer to manipulate the nanomachine with the high precision of NIR light. ...
Artificially cloaked viral nanovaccine for cancer immunotherapy
Nature Communications (IF 11.878) Pub Date : 2019-12-17 ,DOI:10.1038/s41467-019-13744-8
We show that this nanoparticle platform controls the growth of aggressive melanoma and lung tumors in vivo both in preventive and therapeutic setting, creating a highly specific anti-cancer immune response. ...
Anisotropic polymer nanoparticles with controlled dimensions from the morphological transformation of isotropic seeds
Nature Communications (IF 11.878) Pub Date : 2019-11-27 ,DOI:10.1038/s41467-019-13263-6
We present a minimal physical model for MORPH that suggests a general mechanism which is potentially applicable to a large number of polymer/nanoparticle systems. ...
Uniform shape monodisperse single chain nanocrystals by living aqueous catalytic polymerization
Nature Communications (IF 11.878) Pub Date : 2019-06-13 ,DOI:10.1038/s41467-019-10692-1
These findings are a relevant step towards polymer materials based on nanoparticle assembly. ...
Coexistence of Different Charge-Transfer Mechanisms in the Hot-Carrier Dynamics of Hybrid Plasmonic Nanomaterials
Nano Letters (IF 12.279) Pub Date : 2019-04-22 ,DOI:10.1021/acs.nanolett.9b00647
Here, we demonstrate that the two mechanisms can coexist in a nanoparticle–semiconductor hybrid nanomaterial, both leading to faster transfer than carrier relaxation. ...
Fabrication of Metal Nanostructures with Programmable Length and Patterns Using a Modular DNA Platform
Nano Letters (IF 12.279) Pub Date : 2019-03-21 ,DOI:10.1021/acs.nanolett.9b00740
Preloading the molds with nanoparticle seeds subsequently allows the growth of linear gold nanostructures whose lengths are controlled by the DNA structure. ...
A Multifunctional Nanotherapy for Targeted Treatment of Colon Cancer by Simultaneously Regulating Tumor Microenvironment
Theranostics (IF 8.063) Pub Date : 2019-05-31 ,DOI:10.7150/thno.34377
Keywords: colitis-associated colon cancer, anti-inflammation, reactive oxygen species, nanoparticle, camptothecin-11, site-specific therapy ...
Colloidal quantum dot molecules manifesting quantum coupling at room temperature
Nature Communications (IF 11.878) Pub Date : 2019-12-16 ,DOI:10.1038/s41467-019-13349-1
Single nanoparticle spectroscopy unravels the attributes of coupled nanocrystal dimers related to the unique combination of quantum mechanical tunneling and energy transfer mechanisms. ...
In situ formation of mononuclear complexes by reaction-induced atomic dispersion of supported noble metal nanoparticles
Nature Communications (IF 11.878) Pub Date : 2019-11-21 ,DOI:10.1038/s41467-019-12965-1
The dispersive process of the Rh nanoparticle is investigated in depth as an example. The in-situ detected I• radicals and CO molecules are identified to promote the breakage of Rh-Rh bonds and the formation of mononuclear complexes. ...
Copper Nanocubes for CO2 Reduction in Gas Diffusion Electrodes
Nano Letters (IF 12.279) Pub Date : 2019-11-18 ,DOI:10.1021/acs.nanolett.9b02748
We have investigated the effect of Cu nanoparticle shape on the electrocatalysis of CO2 reduction by using gas-diffusion electrodes (GDEs) and flowing alkaline catholytes. Cu nanocubes of ∼70 nm in edge length are synthesized with {100} facets preferentially exposed on the surface. ...
Biologically encoded magnonics
Nature Communications (IF 11.878) Pub Date : 2019-09-25 ,DOI:10.1038/s41467-019-12219-0
Here we demonstrate the feasibility of biogenic nanoparticle chains as the first step to truly nanoscale magnonics at room temperature. ...
Chirality Transfer in Galvanic Replacement Reactions
Nano Letters (IF 12.279) Pub Date : 2019-09-24 ,DOI:10.1021/acs.nanolett.9b03117
Demand for the transfer of chirality from a pre-engineered nanoparticle to any other metal is of fundamental importance for developing a wide range of chirality-related applications. ...
A method for structure prediction of metal-ligand interfaces of hybrid nanoparticles
Nature Communications (IF 11.878) Pub Date : 2019-09-03 ,DOI:10.1038/s41467-019-12031-w
Despite a rapidly growing database of experimentally determined atom-precise nanoparticle structures and their properties, there has been no successful, systematic way to predict the atomistic structure of the metal-ligand interface. ...
Enhanced ion tolerance of electrokinetic locomotion in polyelectrolyte-coated microswimmer
Nature Communications (IF 11.878) Pub Date : 2019-09-02 ,DOI:10.1038/s41467-019-11907-1
Here, we propose that the active nano/microswimmer’s self-electrophoresis is fundamentally different from the passive nanoparticle electrophoresis. ...
Quantitative Imaging of Organic Ligand Density on Anisotropic Inorganic Nanocrystals
Nano Letters (IF 12.279) Pub Date : 2019-09-01 ,DOI:10.1021/acs.nanolett.9b02434
A longstanding challenge in nanoparticle characterization is to understand anisotropic distributions of organic ligands at the surface of inorganic nanoparticles. ...
A stochastic view on surface inhomogeneity of nanoparticles
Nature Communications (IF 11.878) Pub Date : 2019-04-10 ,DOI:10.1038/s41467-019-09595-y
These results cast doubt on the uniform surface coverage commonly assumed in the creation of amorphous functional nanoparticles and expose a striking difference between the average population and individual nanoparticle coverage. ...
Coherent quantum control of nitrogen-vacancy center spins near 1000 kelvin
Nature Communications (IF 11.878) Pub Date : 2019-03-22 ,DOI:10.1038/s41467-019-09327-2
Using the diamond magnetometry based on optically detected magnetic resonance up to 800 K, we observe the magnetic phase transition of a single nickel nanoparticle at about 615 K. This work enables nano-thermometry and nano-magnetometry in the high-temperature regime. ...
Accurate Mass Measurement of a Levitated Nanomechanical Resonator for Precision Force-Sensing
Nano Letters (IF 12.279) Pub Date : 2019-04-01 ,DOI:10.1021/acs.nanolett.9b00082
This critical issue can be addressed in levitodynamics, where the nanoresonator typically consists of a single silica nanoparticle of well-defined mass. ...



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