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2019年生物纳米研究最新热点报道(四)
来源于:纳米医学网 | 作者: | 发布时间:2017-12-31 | 浏览:318




Polymersome nanoreactors with tumor pH-triggered selective membrane permeability for prodrug delivery, activation, and combined oxidation-chemotherapy
Journal of Controlled Release (IF 7.901) Pub Date : 2019-04-23 ,DOI:10.1016/j.jconrel.2019.04.032
The well-devised polymersome nanoreactors with tumor-pH-tunable membrane permeability to coload H2O2-responsive prodrug and GOD represent a novel strategy to realize prodrug delivery and activation for enhanced therapeutic efficacy with low side toxicity. ...
Toward understanding polymer micelle stability: Density ultracentrifugation offers insight into polymer micelle stability in human fluids
Journal of Controlled Release (IF 7.901) Pub Date : 2019-12-24 ,DOI:10.1016/j.jconrel.2019.12.038
Taken together, our data offers both quantitative and qualitative evidence for micelle stability within human biologic fluids and offers evidence of polymer micelle instability in biologic fluids that is not explained by either total protein content or total unsaturated lipid content. ...
Therapeutic Polymersome Nanoreactors with Tumor-Specific Activable Cascade Reactions for Cooperative Cancer Therapy
ACS Nano (IF 13.903) Pub Date : 2019-02-01 ,DOI:10.1021/acsnano.8b09082
Herein, we demonstrate a polymersome nanoreactor with tumor acidity-responsive membrane permeability to activate cascade reactions for orchestrated cooperative cancer treatment. ...
The hard protein corona of stealth liposomes is sparse
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-03 ,DOI:10.1016/j.jconrel.2019.05.042
Both the liposomes recovered after in vitro incubation and the liposomes recovered after in vivo circulation completely retained their size and receptor targeting characteristics. ...
Formulation and manufacturing of lymphatic targeting liposomes using microfluidics
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-03 ,DOI:10.1016/j.jconrel.2019.06.002
These results demonstrate that microfluidics can be used to prepare protein-loaded liposomes that offer enhanced lymphatic targeting and retention of both the liposomes and entrapped antigen. ...
Liposomes for delivery of antioxidants in cosmeceuticals: Challenges and development strategies
Journal of Controlled Release (IF 7.901) Pub Date : 2019-03-07 ,DOI:10.1016/j.jconrel.2019.03.003
Here, we provide a critical review of the major problems complicating the development of liposomes for AO delivery. ...
Extravasating Neutrophils Open Vascular Barrier and Improve Liposomes Delivery to Tumors
ACS Nano (IF 13.903) Pub Date : 2019-10-18 ,DOI:10.1021/acsnano.9b03848
Liposomes are the most extensively used nanocarriers in cancer therapy. Despite the advantages these vehicles provide over free drugs, there are still limitations with regards to the efficiency of liposomesdelivery to tumors and off-target accumulation. ...
Interplay of protein corona and immune cells controls blood residency of liposomes
Nature Communications (IF 11.878) Pub Date : 2019-08-15 ,DOI:10.1038/s41467-019-11642-7
In vivo liposomes, like other types of nanoparticles, acquire a totally new ‘biological identity’ due to the formation of a biomolecular coating known as the protein corona that depends on and modifies the liposomes’ synthetic identity. ...
Photodynamic Therapy with Liposomes Encapsulating Photosensitizers with Aggregation-Induced Emission
Nano Letters (IF 12.279) Pub Date : 2019-02-19 ,DOI:10.1021/acs.nanolett.8b04875
Herein, we proposed a strategy of aggregation-induced emission PSs (AIE-PSs) entrapped in liposomeswith controlled photosensitization. The AIE-PSs begin to lose their photosensitivity when entrapped in liposomes. ...
Full Gamut Wall Tunability from Persistent Micelle Templates via Ex Situ Hydrolysis
Small (IF 10.856) Pub Date : 2019-03-28 ,DOI:10.1002/smll.201900393
Here, an ex situ hydrolysis method is developed for TiO2 that mitigates this depletion of water and nearly decouples materials chemistry from micelle control. ...
Poly(Sarcosine) Surface Modification Imparts Stealth‐Like Properties to Liposomes
Small (IF 10.856) Pub Date : 2019-11-13 ,DOI:10.1002/smll.201904716
Moreover, complement activation, which is a key factor in hypersensitivity reactions caused by PEGylated liposomes, can be reduced by modifying the surface of liposomes with an acetylated BA‐pSar derivative. ...
Tumor-specific delivery of gemcitabine with activatable liposomes
Journal of Controlled Release (IF 7.901) Pub Date : 2019-07-10 ,DOI:10.1016/j.jconrel.2019.07.014
The optimized gemcitabine liposomes released 60% and 80% of the gemcitabine within 1 and 5 min, respectively, at 42 °C. ...
Micelle-Assisted Formation of Nanoparticle Superlattices and Thermally Reversible Symmetry Transitions
Nano Letters (IF 12.279) Pub Date : 2019-01-25 ,DOI:10.1021/acs.nanolett.8b04817
Here, we report a spherical micelle-assisted method to form exceptionally ordered NPSLs which are inherently sensitive to environmental conditions. ...
Nanomaterials: Full Gamut Wall Tunability from Persistent Micelle Templates via Ex Situ Hydrolysis (Small 18/2019)
Small (IF 10.856) Pub Date : 2019-05-03 ,DOI:10.1002/smll.201970092
In article number 1900393, Morgan Stefik and co‐workers improve a micelle template strategy to decouple micelle control from reactive material additions. The series of porous TiO2 materials exhibit tunable confinement effects upon electrochemical lithiation. ...
Non-immunogenic, low-toxicity and effective glioma targeting MTI-31 liposomes
Journal of Controlled Release (IF 7.901) Pub Date : 2019-11-12 ,DOI:10.1016/j.jconrel.2019.11.005
Following this study, DVAP (DPDADVDRDTDNDS) modified liposomes (DVAP-liposomes) were identified as an immunologically safe carrier and therefore utilized for MTI-31 encapsulation. ...
Recent advances on thermosensitive and pH-sensitive liposomes employed in controlled release
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-21 ,DOI:10.1016/j.jconrel.2019.09.018
Among them, one of the most attractive and well-investigated nanocarriers are liposomes. ...
Membrane Tension–Mediated Growth of Liposomes
Small (IF 10.856) Pub Date : 2019-07-31 ,DOI:10.1002/smll.201902898
The results show that growth of liposomes can be realized in a protein‐free minimal system, which may find useful applications in achieving autonomous synthetic cells that are capable of undergoing a continuous growth–division cycle. ...
Spatiotemporal control of coacervate formation within liposomes
Nature Communications (IF 11.878) Pub Date : 2019-04-17 ,DOI:10.1038/s41467-019-09855-x
Here, we use a microfluidics-based methodology to form coacervates inside cell-sized (~10 µm) liposomes, allowing control over the dynamics. ...
Nonequilibrium Reshaping of Polymersomes via Polymer Addition
ACS Nano (IF 13.903) Pub Date : 2019-11-11 ,DOI:10.1021/acsnano.9b04740
Polymersomes are a class of artificial liposomes, assembled from amphiphilic synthetic block copolymers, holding great promise toward applications in nanomedicine. ...
Thioether Phosphatidylcholine Liposomes: A Novel ROS-Responsive Platform for Drug Delivery
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-07 ,DOI:10.1021/acsami.9b08901
After that, S-PC-based stealth liposomes (S-LPs) containing DSPE-PEG2000 and cholesterol were prepared via a classic thin-film method. Doxorubicin (DOX) as a model drug was loaded in the stealth liposomes (DOX/S-LPs) by using the ammonium sulfate gradient method with high encapsulation efficiency. ...
Dual functionalized liposomes for efficient co-delivery of anti-cancer chemotherapeutics for the treatment of glioblastoma
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-26 ,DOI:10.1016/j.jconrel.2019.06.033
The biodistribution of Tf-Pen liposomes demonstrated ~12 and 3.3 fold increase in doxorubicin and erlotinib accumulation in mice brain, respectively compared to free drugs. ...
Atomic force microscopy measurements of anionic liposomes reveal the effect of liposomal rigidity on antigen-specific regulatory T cell responses
Journal of Controlled Release (IF 7.901) Pub Date : 2019-12-05 ,DOI:10.1016/j.jconrel.2019.12.003
Next, we assessed if rigidity affects the association of liposomes to bone marrow-derived dendritic cells (BMDCs) in vitro. Aside from DOPC:DOPG liposomes, we observed a positive correlation between liposomal rigidity and cellular association. ...
Tyrosine modified irinotecan-loaded liposomes capable of simultaneously targeting LAT1 and ATB0,+ for efficient tumor therapy
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-30 ,DOI:10.1016/j.jconrel.2019.10.037
Targeted ability was achieved through inserting different amino acids modified polyethylene glycol monostearate into the liposomes, and found that glutamate-liposomes can be targeted to LAT1, lysine-liposomes can be targeted to ATB0,+, and inspiringly, tyrosine-liposomes can be simultaneously targeted ...
Regulatory T Cells Tailored with pH-Responsive Liposomes Shape an Immuno-Antitumor Milieu against Tumors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-27 ,DOI:10.1021/acsami.9b11371
Herein, a strategy for harnessing regulatory T (Treg) cells is developed as an actively targeting drug-delivery system to transport drug-loaded liposomes to the desired tumor sites via conjugating liposomeson the surface of Treg cells. ...
The role of liposomes in clinical nanomedicine development. What now? Now what?
Journal of Controlled Release (IF 7.901) Pub Date : 2019-12-14 ,DOI:10.1016/j.jconrel.2019.12.023
Research priorities for the future will be outlined based on experience with the most successful nanomedicines family within the broad field of nanomedicine so far: liposomes. An analysis of currently clinically tested, approved and marketed liposome-drug combinations provide these insights. ...
A multifunctional lipid that forms contrast-agent liposomes with dual-control release capabilities for precise MRI-guided drug delivery
Biomaterials (IF 10.273) Pub Date : 2019-08-06 ,DOI:10.1016/j.biomaterials.2019.119412
We first confirmed that both photo-treatment and pH-triggered hydrolysis are able to cleave the GDO lipid and lyse GDO liposomes. We then investigated the efficiency of drug release via the combined release processes for GDO liposomes loaded with doxorubicin (DOX). ...
Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions
ACS Nano (IF 13.903) Pub Date : 2019-08-06 ,DOI:10.1021/acsnano.9b03942
We also observed a rapid decline of anti-PEG IgM in the blood within minutes, increased binding of PEGylated liposomes to IgM+ B cells in the spleen of immunized animals compared to control, and increased C3 conversion by PEGylated liposomes in the serum of immunized pigs. ...
Engineering of Bone- and CD44-Dual-Targeting Redox-Sensitive Liposomes for the Treatment of Orthotopic Osteosarcoma
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-07 ,DOI:10.1021/acsami.8b18820
This ALN–HA conjugate was coupled with DSPE–PEG2000–COOH through a bioreducible disulfide linker (−SS−) to obtain a functionalized lipid, ALN–HA–SS–L, to be postinserted into preformed liposomesloaded with doxorubicin (DOX). ...
Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated liposomes by pre-infusion with high molecular weight free PEG
Journal of Controlled Release (IF 7.901) Pub Date : 2019-08-24 ,DOI:10.1016/j.jconrel.2019.08.017
Importantly, the infusion of free PEG appeared to be safe in mice previously sensitized by injection of PEGylated liposomes, and free PEG did not elicit excess APA production even in mice with pre-existing adaptive immunity against PEG. ...
An Investigation of PS‐b‐PEO Polymersomes for the Oral Treatment and Diagnosis of Hyperammonemia
Small (IF 10.856) Pub Date : 2019-11-13 ,DOI:10.1002/smll.201902347
Due to its high sensitivity and selectivity, this polymersome‐based assay could prove useful in the monitoring of hyperammonemic patients and in other applications such as drug screening tests. ...
Solution Conditions Tune and Optimize Loading of Therapeutic Polyelectrolytes into Layer-by-Layer Functionalized Liposomes
ACS Nano (IF 13.903) Pub Date : 2019-04-18 ,DOI:10.1021/acsnano.9b00792
Here, we focus on addressing some of the fundamental questions that must be answered in order to obtain a reliable and robust synthesis of nucleic acid-containing LbL liposomes. ...
Multifunctional Theranostic Liposomes Loaded with a Hypoxia-Activated Prodrug for Cascade-Activated Tumor Selective Combination Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-16 ,DOI:10.1021/acsami.9b11080
The photothermal agent indocyanine green (ICG) and hypoxia-activated prodrug tirapazamine (TPZ) were coencapsulated into the liposomes, followed by modification with cRGD and conjugation with GdIII to form ICG/TPZ@Ce6-GdIII theranostic liposomes (ITC-GdIII TLs). ...
Can intracellular drug delivery using hyaluronic acid functionalised pH-sensitive liposomes overcome gemcitabine resistance in pancreatic cancer?
Journal of Controlled Release (IF 7.901) Pub Date : 2019-05-13 ,DOI:10.1016/j.jconrel.2019.05.018
HA facilitated cell uptake without compromising the endosome-escape ability of pSL as evidenced by confocal images and co-localization analysis of the dual-fluorescence labelled liposomes and Lysotracker. ...
Sonoprinting liposomes on tumor spheroids by microbubbles and ultrasound
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-29 ,DOI:10.1016/j.jconrel.2019.10.051
Using doxorubicin-liposome-loaded microbubbles, we show that sonoprinting allows to deposit large amounts of doxorubicin-containing liposomes to the outer cell layers of the spheroids, followed by doxorubicin release into the deeper layers of the spheroids, resulting in a significant reduction in cell ...
Coalescence of a water drop with an air-liquid interface: Electric current generation and critical micelle concentration (CMC) sensing application
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-01 ,DOI:10.1021/acsami.9b00365
Determining the critical micelle concentration (CMC) using this system was successfully achieved to show the powerfulness of this system. ...
Facile Fabrication of an Amentoflavone-Loaded Micelle System for Oral Delivery To Improve Bioavailability and Hypoglycemic Effects in KKAy Mice
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-22 ,DOI:10.1021/acsami.9b03275
In order to increase the oral bioavailability and antidiabetic effect of amentoflavone with multimechanisms, an oral micelle system was developed by using a N-vinyl pyrrolidone-maleate-guerbet alcohol monoester polymer for the first time, which was designated as P(NVP-MGAM)/AF. ...
Photopolymerized Micelle‐Laden Hydrogels Can Simultaneously Form and Encapsulate Nanocrystals to Improve Drug Substance Solubility and Expedite Drug Product Design
Small (IF 10.856) Pub Date : 2019-01-15 ,DOI:10.1002/smll.201803372
By integrating nanocrystals into a final dosage form, micelle‐laden hydrogels simplify hydrophobic drug product design. ...
Light-Cross-linked Enediyne Small-Molecule Micelle-Based Drug-Delivery System
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-19 ,DOI:10.1021/acsami.8b22516
The drug-loaded micelles, as an example of light-cross-linked small-molecule micelle-based drug-delivery system, exhibit high drug-loading contents (50%) and greatly improved cytotoxicity toward A549 cells (decreasing the IC50 value of Gemcitabine by 10 times), thanks to the greatly increased cellular ...
Overcoming the Anatomical and Physiological Barriers in Topical Eye Surface Medication Using a Peptide-Decorated Polymeric Micelle
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-16 ,DOI:10.1021/acsami.9b13851
Thanks to the existence of a negatively charged mucin layer on the eye surface, several peptide-decorated polymeric micelles were prepared to enhance the interaction between the micelle and eye surface, thus prolonging the drug retention on the eye surface and promoting its tissue permeability. ...
Liposomes of Quantum Dots Configured for Passive and Active Delivery to Tumor Tissue
Nano Letters (IF 12.279) Pub Date : 2019-08-22 ,DOI:10.1021/acs.nanolett.9b01027
Hydrophilic QDs were synthesized and entrapped in functionalized liposomes, conferring passive (“stealth” NPs; PEGylated, neutral charge) and active (monocyte-mediated delivery; positively charged) properties by differing in their lipid composition, membrane PEGylation, and charge (positively, negatively ...
A study of the endocytosis mechanism and transendothelial activity of lung-targeted GALA-modified liposomes
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-08 ,DOI:10.1016/j.jconrel.2019.06.009
We recently found that liposomes modified with GALA peptide (GALA-LPs) extensively accumulate in lung endothelial cells (ECs) after intravenous injection. However, the uptake mechanism of GALA-LPs and their ability to reach alveolar epithelium was unclear. ...
Comment on “Topical Delivery of Avastin to the Posterior Segment of the Eye In Vivo Using Annexin A5‐Associated Liposomes”: Topical Liposomal Bevacizumab Results in Negligible Retinal Concentrations
Small (IF 10.856) Pub Date : 2019-03-14 ,DOI:10.1002/smll.201805199
The previously published report suggests that liposomes, functionalized with annexin‐5, can deliver bevacizumab to the retina after topical administration as eyedrops. ...
Sequential depletion of myeloid-derived suppressor cells and tumor cells with a dual-pH-sensitive conjugated micelle system for cancer chemoimmunotherapy
Journal of Controlled Release (IF 7.901) Pub Date : 2019-11-20 ,DOI:10.1016/j.jconrel.2019.11.011
Here we have designed a dual-pH-sensitivity conjugated micelle system (PAH/RGX-104@PDM/PTX) that could deliver liver-X nuclear receptor (LXR) agonist RGX-104 and paclitaxel (PTX) to the perivascular region and tumor cells, respectively. ...
Micelle-Embedded Layer-by-Layer Coating with Catechol and Phenylboronic Acid for Tunable Drug Loading, Sustained Release, Mild Tissue Response, and Selective Cell Fate for Re-endothelialization
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-01 ,DOI:10.1021/acsami.9b01253
With an ingenious design, a self-healing sandwiched layer-by-layer (LBL) coating was constructed by using chitosan/heparin as adopted polyelectrolytes with embedding of micelles, in which the chitosan backbone was grafted with catechol and the micelle was modified with exposed phenylboronic acid, endowing ...
Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer
ACS Nano (IF 13.903) Pub Date : 2019-10-31 ,DOI:10.1021/acsnano.9b04676
Inspired by the adeno-associated virus (AAV) as a prime example of a transcriptionally active ssDNA system, we considered a methodology that can capture unpaired ssDNA within the polyplex micellesystem (PM), an assembly of DNA and poly(ethylene glycol)-b-poly(l-lysine) (PEG-PLys). ...
Role of Liposome Size, Surface Charge, and PEGylation on Rheumatoid Arthritis Targeting Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-22 ,DOI:10.1021/acsami.8b22693
Uptake of fluorescent liposomes by various synovial cells was measured by flow cytometry. ...
Doxebo (doxorubicin-free Doxil-like liposomes) is safe to use as a pre-treatment to prevent infusion reactions to PEGylated nanodrugs
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-06 ,DOI:10.1016/j.jconrel.2019.06.007
We previously showed that an intravenous injection of doxorubicin-free Doxil-like PEGylated nano-liposomes (Doxebo) prior to Doxil treatment suppresses Doxil-induced complement activation-related pseudoallergy (CARPA) in pigs, a model of human hypersensitivity reactions to Doxil. ...
Novel ginsenoside-based multifunctional liposomal delivery system for combination therapy of gastric cancer
Theranostics (IF 8.063) Pub Date : 2019-06-09 ,DOI:10.7150/thno.34953
The stability of the ginsenoside liposomes was determined by particle size analysis using dynamic light scattering. The long circulation time of ginsenoside liposomes was compared with that of conventional liposome and polyethylene glycosylated liposomes in vivo. ...
Indocyanine Green J Aggregates in Polymersomes for Near-Infrared Photoacoustic Imaging
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-05 ,DOI:10.1021/acsami.9b14519
The encapsulated J aggregates were protected against dissociation by the polymersome shell for 24 h in 100% fetal bovine serum, after which the polymersomes biodegraded and the J aggregates dissociated to ICG monomers. ...
Combining vascular targeting and the local first pass provides 100-fold higher uptake of ICAM-1-targeted vs untargeted nanocarriers in the inflamed brain
Journal of Controlled Release (IF 7.901) Pub Date : 2019-03-11 ,DOI:10.1016/j.jconrel.2019.03.008
., uptake of anti-ICAM-1/liposomes was 100-fold higher vs IgG/liposomes). These data affirm the specificity of the combined effect of the first pass and immunotargeting. ...
An integrin-based nanoparticle that targets activated hepatic stellate cells and alleviates liver fibrosis
Journal of Controlled Release (IF 7.901) Pub Date : 2019-04-17 ,DOI:10.1016/j.jconrel.2019.04.022
Moreover, treatment of mice with vismodegib-loaded cRGDyK-liposomes markedly inhibited the fibrogenic phenotype in bile duct ligation- or thioacetamide-treated mice. We conclude that the cRGDyK-guided liposomes can specifically target the activated HSCs, but not quiescent HSCs. ...
Ulcerative colitis-specific delivery of keratinocyte growth factor by neutrophils-simulated liposomes facilitates the morphologic and functional recovery of the damaged colon through alleviating the inflammation
Journal of Controlled Release (IF 7.901) Pub Date : 2019-02-23 ,DOI:10.1016/j.jconrel.2019.02.034
Herein, KGF was firstly encapsulated into the liposomes (KGF-Lips) to improve its stability. Thereafter, the neutrophil membrane vesicle (NEM) was extracted from the activated neutrophil which was isolated from the healthy mice and then activated by lipopolysaccharide. ...
Multifunctional Thermosensitive Liposomes Based on Natural Phase-Change Material: Near-Infrared Light-Triggered Drug Release and Multimodal Imaging-Guided Cancer Combination Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-08 ,DOI:10.1021/acsami.8b22748
Herein, the near-infrared (NIR)-absorbing dye, indocyanine green (ICG), and the antitumor drug, doxorubicin (DOX), were efficiently coencapsulated into the thermosensitive liposomes based on natural phase-change material. ...
Living Supramolecular Polymerization of Rod–Coil Block Copolymers: Kinetics, Origin of Uniformity, and Its Implication
Nano Letters (IF 12.279) Pub Date : 2019-02-13 ,DOI:10.1021/acs.nanolett.9b00163
The rate coefficient in the proposed kinetics theory decreases with increasing cylindrical micelle length, which is attributed to micelle rigidity and unique diffusion behavior. ...
The Binary Effect on Methicillin‐Resistant Staphylococcus aureus of Polymeric Nanovesicles Appended by Proline‐Rich Amino Acid Sequences and Inorganic Nanoparticles
Small (IF 10.856) Pub Date : 2019-04-08 ,DOI:10.1002/smll.201804247
This bacteriostatic activity, coupled with nominal cytotoxicity toward native human dermal fibroblast cells, extends the potential for AMP/AgNP polymersome therapies to replace antibiotics in the clinical setting. ...
Heuristics for the Optimal Presentation of Bioactive Peptides on Polypeptide Micelles
Nano Letters (IF 12.279) Pub Date : 2019-10-29 ,DOI:10.1021/acs.nanolett.9b03141
This system consists of micelles of a recombinant elastin-like polypeptide diblock copolymer (ELPBC) that present genetically encoded peptides at the micelle surface without perturbing the size, shape, stability, or peptide valency of the micelle, regardless of the peptide type. ...
Protein-Engineered Nanoscale Micelles for Dynamic 19F Magnetic Resonance and Therapeutic Drug Delivery
ACS Nano (IF 13.903) Pub Date : 2019-02-19 ,DOI:10.1021/acsnano.8b07481
The assembly of the F-TRAP micelle, composed of a coiled-coil pentamer corona and a hydrophobic, thermoresponsive elastin-like polypeptide core, results in a drastic depression in spin–spin relaxation (T2) times and unaffected spin–lattice relaxation (T1) times. ...
Mesoporous Au3Pd Film on Ni Foam: A Self-Supported Electrocatalyst for Efficient Synthesis of Ammonia
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-23 ,DOI:10.1021/acsami.9b14187
Herein, self-supported mesoporous Au3Pd film on Ni foam (mAu3Pd/NF) has been in situ synthesized via a micelle-assisted replacement strategy. ...
Electrochemical Fabrication of Porous Au Film on Ni Foam for Nitrogen Reduction to Ammonia
Small (IF 10.856) Pub Date : 2019-01-13 ,DOI:10.1002/smll.201804769
Herein, a micelle‐assisted electrodeposition method is presented for the direct fabrication of porous Au film on Ni foam (pAu/NF). ...
A Multifunctional Lipid Incorporating Active Targeting and Dual-Control Release Capabilities for Precision Drug Delivery
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-17 ,DOI:10.1021/acsami.9b14470
We then prepared a series of liposomes (termed FOBD liposomes) by compounding the Fa-ONB lipid with DOPC at different ratios. ...
Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications
Biomaterials (IF 10.273) Pub Date : 2019-12-23 ,DOI:10.1016/j.biomaterials.2019.119706
However, some drawbacks limit the application of liposomes in clinical, such as problems in transporting, storing, and difficulties in maintaining the drug concentration in the local area. ...
Chain-Length- and Saturation-Tuned Mechanics of Fluid Nanovesicles Direct Tumor Delivery
ACS Nano (IF 13.903) Pub Date : 2019-06-12 ,DOI:10.1021/acsnano.9b01181
In contrast, stiff liposomes hardly deformed, whereas soft liposomes changed their shape irregularly, which slowed their MCS penetration. ...
Immunomodulatory Lipocomplex Functionalized with Photosensitizer-Embedded Cancer Cell Membrane Inhibits Tumor Growth and Metastasis
Nano Letters (IF 12.279) Pub Date : 2019-07-16 ,DOI:10.1021/acs.nanolett.9b01571
Liposomes are clinically used as drug carriers for cancer therapy; however, unwanted leakage of the encapsulated anticancer drug and poor tumor-targeting efficiency of liposomes may generate toxic side effects on healthy cells and lead to failure of tumor eradication. ...
Indium-111 labelling of liposomal HEGF for radionuclide delivery via ultrasound-induced cavitation
Journal of Controlled Release (IF 7.901) Pub Date : 2019-12-28 ,DOI:10.1016/j.jconrel.2019.12.045
However, in contrast to non-radioactive agents, loading and release of radiotherapeutics from liposomescan be challenging in the clinical setting. ...
Polymeric Hybrid Nanomicelles for Cancer Theranostics: An Efficient and Precise Anticancer Strategy for the Codelivery of Doxorubicin/miR-34a and Magnetic Resonance Imaging
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-15 ,DOI:10.1021/acsami.9b14908
Therefore, we established a hybrid micelle to offer a promising theranostic approach that inhibits tumor growth and enhances MR imaging. ...
An activated-platelet-sensitive nanocarrier enables targeted delivery of tissue plasminogen activator for effective thrombolytic therapy
Journal of Controlled Release (IF 7.901) Pub Date : 2019-02-23 ,DOI:10.1016/j.jconrel.2019.02.033
Furthermore, almost complete blood clot lysis was achieved in 75 min, showing considerably higher and quicker thrombolytic activity compared to the tPA-loaded liposomes without cRGD labelling. ...
Moebius strips of chiral block copolymers
Nature Communications (IF 11.878) Pub Date : 2019-09-09 ,DOI:10.1038/s41467-019-11991-3
The Moebius strip is formed by morphological evolution from large compound micelle (LCM) to spindle-like micelle (SLM) and then to toroid with a 180° twist along the ring. ...
Hofmeister interaction in the driver’s seat
Nature Nanotechnology (IF 33.407) Pub Date : 2019-11-18 ,DOI:10.1038/s41565-019-0581-0
The self-propulsion direction of enzyme-loaded liposomes is controlled by the activity of the ions in solution. ...
Optimizing design parameters of a peptide targeted liposomal nanoparticle in an in vivo multiple myeloma disease model after initial evaluation in vitro
Journal of Controlled Release (IF 7.901) Pub Date : 2019-08-29 ,DOI:10.1016/j.jconrel.2019.08.033
Hence, further optimization using in vivo models was absolutely necessary, through which we were able to increase the uptake of peptide-targeted liposomes by cancerous cells overexpressing VLA-4 to 15-fold over that of non-targeted liposomes in vivo. ...
In Situ Dendritic Cell Vaccine for Effective Cancer Immunotherapy
ACS Nano (IF 13.903) Pub Date : 2019-03-07 ,DOI:10.1021/acsnano.8b08346
The chimeric cross-linked polymersome (CCPS) is acquired from self-assembly of a triblock copolymer, polyethylene glycol-poly(methyl methyacrylate-co-2-amino ethyl methacrylate (thiol/amine))-poly 2-(dimethylamino)ethyl methacrylate (PEG-P(MMA-co-AEMA (SH/NH2)-PDMA). ...
Ultrasound-mediated cavitation enhances the delivery of an EGFR-targeting liposomal formulation designed for chemo-radionuclide therapy
Theranostics (IF 8.063) Pub Date : 2019-07-28 ,DOI:10.7150/thno.34669
Finally, the influence of ultrasound-mediated cavitation on the delivery of liposomes into tumours was studied. Results: Liposomes were loaded efficiently with Dox, surface decorated with 111In-EGF and showed selective uptake in MDA-MB-468 cells compared to MCF7. ...
Liver fibrosis affects the targeting properties of drug delivery systems to macrophage subsets in vivo
Biomaterials (IF 10.273) Pub Date : 2019-03-22 ,DOI:10.1016/j.biomaterials.2019.03.025
Drug delivery systems, such as polymers, liposomes and microbubbles, efficiently target myeloid cells in healthy liver, but their targeting properties in hepatic fibrosis remain elusive. ...
Liposomal Formulations of Photosensitizers
Biomaterials (IF 10.273) Pub Date : 2019-07-10 ,DOI:10.1016/j.biomaterials.2019.119341
Furthermore, research efforts have examined the impact of co-loading therapeutic cargo along with photosensitizers within liposomes. Additional recent approaches including imaging, overcoming hypoxia, upconversion and activatable liposomal formulations are discussed. ...
In Vivo Environment‐Adaptive Nanocomplex with Tumor Cell–Specific Cytotoxicity Enhances T Cells Infiltration and Improves Cancer Therapy
Small (IF 10.856) Pub Date : 2019-09-04 ,DOI:10.1002/smll.201902822
Aspirin (ASP), which has the activity of anti‐metastasis and enhancing T cells infiltration in tumors, is encapsulated into the HS‐DTX micelle. ...
Selective Liposomal Transport through Blood Brain Barrier Disruption in Ischemic Stroke Reveals Two Distinct Therapeutic Opportunities
ACS Nano (IF 13.903) Pub Date : 2019-11-06 ,DOI:10.1021/acsnano.9b01808
Here, in a mouse model of stroke, we show selective recruitment of clinically used liposomes into the ischemic brain that correlates with biphasic blood brain barrier (BBB) breakdown. ...
Oriented Assembly of Cell-Mimicking Nanoparticles via a Molecular Affinity Strategy for Targeted Drug Delivery
ACS Nano (IF 13.903) Pub Date : 2019-04-29 ,DOI:10.1021/acsnano.8b09681
The membrane-coated liposomes exhibited an appropriate size distribution around 100 nm and high stability, with superior circulation durations compared with those of conventional PEGylated liposomes. ...
Extracellular matrix-penetrating nanodrill micelles for liver fibrosis therapy
Biomaterials (IF 10.273) Pub Date : 2019-12-06 ,DOI:10.1016/j.biomaterials.2019.119616
Upon encountering collagen I barrier, CRM exerted a nanodrill-like function, efficiently degrading pericellular collagen I and showing greater uptake by human HSCs than other micelle formulations. ...
Octreotide-Conjugated Core-Cross-Linked Micelles with pH/Redox Responsivity Loaded with Etoposide for Neuroendocrine Neoplasms Therapy and Bioimaging with Photoquenching Resistance
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-07 ,DOI:10.1021/acsami.9b01827
Considering the active tumor targeting, dual-responsive drug release and the AIE effect, the polymer micelle system will be a potential candidate for diagnosis and oncotherapy of NENs. ...
A Two-Step Precise Targeting Nanoplatform for Tumor Therapy via the Alkyl Radicals Activated by the Microenvironment of Organelles
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-28 ,DOI:10.1016/j.jconrel.2019.10.017
Then, folic acid (FA) targeted pH-sensitive liposomes containing docetaxel (Lipo/DTX-FA) were prepared by thin-film dispersion method, and the core-shell AIPH/MSN-TPP@Lipo/DTX-FA nanoparticles were constructed by self-assembly during the hydration of the liposomes. ...
Cell-penetrating mechanism of intracellular targeting albumin: Contribution of macropinocytosis induction and endosomal escape
Journal of Controlled Release (IF 7.901) Pub Date : 2019-05-10 ,DOI:10.1016/j.jconrel.2019.05.015
Using liposomes that mimic endosomes, the leakage of 5,6-carboxyfluorescein from liposome was observed in the presence of palmitoyl-cyclic-(D-Arg)12/HSA only in the case of the anionic late endosome-like liposomes but not the neutral early endosome-like liposomes. ...
Liposomal dexamethasone inhibits tumor growth in an advanced human-mouse hybrid model of multiple myeloma
Journal of Controlled Release (IF 7.901) Pub Date : 2019-01-22 ,DOI:10.1016/j.jconrel.2019.01.028
Besides the organs involved in clearance, liposomes were also found to accumulate in tumor bearing human-bone scaffolds. ...
Dual Stable Nanomedicines Prepared by Cisplatin-Crosslinked Camptothecin Prodrug Micelles for Effective Drug Delivery
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-31 ,DOI:10.1021/acsami.9b03960
This design ingeniously solved the contradiction between the stability and release of polymer micelle-based nanomedicines. ...
Bubble-Manipulated Local Drug Release from a Smart Thermosensitive Cerasome for Dual-Mode Imaging Guided Tumor Chemo-Photothermal Therapy.
Theranostics (IF 8.063) Pub Date : 2019-11-23 ,DOI:10.7150/thno.36762
Thermosensitive liposomes have demonstrated great potential for tumor-specific chemotherapy. Near infrared (NIR) dyes loaded liposomes have also shown improved photothermal effect in cancer theranostics. ...
Sodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin
Journal of Controlled Release (IF 7.901) Pub Date : 2019-01-05 ,DOI:10.1016/j.jconrel.2019.01.004
Analyzing nanoparticle biodistribution within the tumor tissue revealed that 93% of the PEGylated liposomes accumulated in the extracellular matrix, while 7% were detected intracellularly. Mice administered bicarbonate-loaded liposomes reached an intra-tumor pH value of 7.38 ± 0.04. ...
Promoting Early Diagnosis and Precise Therapy of Hepatocellular Carcinoma by Glypican-3-Targeted Synergistic Chemo-Photothermal Theranostics
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-19 ,DOI:10.1021/acsami.9b05526
GSI-Lip showed a higher antitumor efficacy in comparison with folic acid-modified liposomes (inhibition rate: 90.52% vs 84.22%, respectively; p < 0.01). ...
Aqueous Nanoparticles: Control of Shell Morphology in p–n Heterostructured Water‐Processable Semiconductor Colloids: Toward Extremely Efficient Charge Separation (Small 2/2019)
Small (IF 10.856) Pub Date : 2019-01-11 ,DOI:10.1002/smll.201970009
The NPs exhibit shell morphology‐dependent photonic particle activity, and they show ultra‐fast charge separation and stable property compared with single PC60 micelle‐covered colloids. ...
Overcoming Biological Barriers in Neuroblastoma Therapy: The Vascular Targeting Approach with Liposomal Drug Nanocarriers
Small (IF 10.856) Pub Date : 2019-02-01 ,DOI:10.1002/smll.201804591
Furthermore, peptide‐tagged liposomal formulations are proved to be more efficacious in inhibiting tumor growth and metastatic spreading of neuroblastoma than nontargeted liposomes. ...
Formulation optimization of an ephrin A2 targeted immunoliposome encapsulating reversibly modified taxane prodrugs
Journal of Controlled Release (IF 7.901) Pub Date : 2019-08-07 ,DOI:10.1016/j.jconrel.2019.08.006
The taxane prodrug was stabilized with extraliposomal citric acid and subsequently loaded into liposomes containing a gradient of SOS, resulting in highly stable SOS-drug complexes being formed inside the liposome. ...
Vasodilator Hydralazine Promotes Nanoparticle Penetration in Advanced Desmoplastic Tumors
ACS Nano (IF 13.903) Pub Date : 2019-01-17 ,DOI:10.1021/acsnano.8b07830
After three injections of HDZ–liposomes at a dose of 15 mg/kg, the tumor stroma was remarkably reduced, along with ameliorated tumor hypoxia in murine models of desmoplastic melanoma (BPD6). ...
Brain-targeted drug delivery by manipulating protein corona functions
Nature Communications (IF 11.878) Pub Date : 2019-08-08 ,DOI:10.1038/s41467-019-11593-z
Doxorubicin loaded SP-sLip (SP-sLip/DOX) show significant enhancement of brain distribution and anti-brain cancer effect in comparison to doxorubicin loaded plain liposomes. ...
Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo
Journal of Controlled Release (IF 7.901) Pub Date : 2019-01-10 ,DOI:10.1016/j.jconrel.2019.01.005
We also find that TfR-targeting on liposomes in the mouse may induce severe adverse effects after intravenous administration. ...
Use of Core-Cross-Linked Polymeric Micelles Induced by the Selective Detection of Cu(II) Ions for the Sustained Release of a Model Drug
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-04 ,DOI:10.1021/acsami.9b02432
As Cu(II) ions slowly penetrated the core of p(DMA-b-PVHC) micelles, these cores cross-linked with each other, which in turn resulted in the micelle particles swelling in water. ...
Tailoring the Shape and Size of Artificial Cells
ACS Nano (IF 13.903) Pub Date : 2019-07-12 ,DOI:10.1021/acsnano.9b05112
So far, various physicochemical and mechanical interventions have been employed to tailor the dimensions of model systems such as liposomes, emulsions, coacervates, and polymer capsules. ...
Tailoring the lipid composition of nanoparticles modulates their cellular uptake and affects the viability of triple negative breast cancer cells
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-22 ,DOI:10.1016/j.jconrel.2019.06.025
Liposomes composed of DMPC (14:0) showed increased cellular uptake when enriched with cholesterol, both by endocytosis and by fusion. Contrarily, the effect of cholesterol on HSPC (18:0) liposomal uptake was minimal. ...
Designed Patterning of Mesoporous Metal Films Based on Electrochemical Micelle Assembly Combined with Lithographical Techniques
Small (IF 10.856) Pub Date : 2019-10-11 ,DOI:10.1002/smll.201902934
Mesoporous noble metals and their patterning techniques for obtaining unique patterned structures are highly attractive for electrocatalysis, photocatalysis, and optoelectronics device applications owing to their expedient properties such as high level of exposed active locations, cascade electrocatalytic sites, and large surface area. However, patterning techniques for mesoporous substrates are still limited to metal oxide and silica films, although there is growing demand for developing techniques related to patterning mesoporous metals. In this study, the first demonstration of mesoporous metal films on patterned gold (Au) substrates, prefabricated using photolithographic techniques, is reported. First, different growth rates of mesoporous Au metal films on patterned Au substrates are demonstrated by varying deposition times and voltages. In addition, mesoporous Au films are also fabricated on various patterns of Au substrates including stripe and mesh lines. An alternative fabrication method using a photoresist insulating mask also yields growth of mesoporous Au within the patterning. Moreover, patterned mesoporous films of palladium (Pd) and palladium–copper alloy (PdCu) are demonstrated on the same types of substrates to show versatility of this method. Patterned mesoporous Au films (PMGF) shows higher electrochemically‐active surface area (ECSA) and higher sensitivity toward glucose oxidation than nonpatterned mesoporous Au films (NMGF). ...
Post-production modifications of murine mesenchymal stem cell (mMSC) derived extracellular vesicles (EVs) and impact on their cellular interaction
Biomaterials (IF 10.273) Pub Date : 2019-12-07 ,DOI:10.1016/j.biomaterials.2019.119675
We evidenced the interest of using EVs instead of liposomes, in regards to target cell internalisation efficiency. EVs were shown to be internalised through a caveolae and cholesterol-dependent pathway, following a different endocytic route than liposomes. ...
pH‐Responsive PEG‐Shedding and Targeting Peptide‐Modified Nanoparticles for Dual‐Delivery of Irinotecan and microRNA to Enhance Tumor‐Specific Therapy
Small (IF 10.856) Pub Date : 2019-11-11 ,DOI:10.1002/smll.201903296
Herein, pH‐sensitive and peptide‐modified liposomes and solid lipid nanoparticles (SLN) are designed for encapsulation of irinotecan and miR‐200, respectively. ...
Correction to Acid-Triggered Nanoexpansion Polymeric Micelles for Enhanced Photodynamic Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-09 ,DOI:10.1021/acsami.9b21100
(a) Acid-responsive process of the PM micelle. (b) UV/vis absorption spectra of PM copolymer in THF and PM micelles in water. (c) Hydrolysis kinetics of PM micelles at different pH values (5.0, 6.8, and 7.4) by measuring the change in UV/vis absorbance at 292 nm. ...
Tailored Design of Mesoporous PdCu Nanospheres with Different Compositions Using Polymeric Micelles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-25 ,DOI:10.1021/acsami.9b09737
We previously reported the preparation of mesoporous Pd using block copolymer micelle templates (Chem. Sci.2019, 10, 4054). Here we extend this synthetic concept to generate alloyed spherical palladium–copper (PdCu) nanoparticles with an open porous network and uniform morphology. ...
Catalytic Biosensors from Complex Coacervate Core Micelle (C3M) Thin Films
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-23 ,DOI:10.1021/acsami.9b08478
Enzymes have been applied to a variety of industrially and medically relevant chemistries as both catalysts and sensors. Incorporation of proteins and enzymes into complex coacervates has been demonstrated to improve the thermal, chemical, and temporal stability of enzymes in solution. In this work, a neutral-cationic block copolymer and an enzyme, alkaline phosphatase, are incorporated into complex coacervate core micelles (C3Ms) and coated onto a solid substrate to create a biocatalytic film from aqueous solution. The incorporation of photo-cross-linkable groups into the neutral block of the polymer allows the film to be cross-linked under ultraviolet light, rendering it insoluble. The morphology of the film is shown to depend most strongly on the protein loading within the film, while solvent annealing is shown to have a minimal effect. These films are then demonstrated as specific sensors for Zn2+ in solution in the presence of other metals, a model reaction for ion-selective heavy metal biosensing useful in environmental monitoring. They are shown to have low leaching and maintain sufficient activity and response for sensing for 1 month after aging under ambient conditions and at 40 °C and 50% relative humidity. The C3M immobilization method demonstrated can be applied to a wide variety of proteins with minimal chemical or genetic modification and could be used for immobilization of charged macromolecules in general to produce a wide variety of thin-film devices. ...
Overcoming the Reticuloendothelial System Barrier to Drug Delivery with a “Don’t-Eat-Us” Strategy
ACS Nano (IF 13.903) Pub Date : 2019-11-07 ,DOI:10.1021/acsnano.9b05679
First, a CD47-derived, enzyme-resistant peptide ligand was designed and placed on liposomes (d-self-peptide-labeled liposome, DSL). ...
Adhesive nanoparticles with inflammation regulation for promoting skin flap regeneration
Journal of Controlled Release (IF 7.901) Pub Date : 2019-01-25 ,DOI:10.1016/j.jconrel.2019.01.031
The aim of this study was to develop novel multipotent flap-protective adhesive mangiferin (MF)-loaded liposomes (A-MF-Lip), bioinspired in mussel architecture, for the promotion of random skin flap regeneration. ...
An iRGD-conjugated prodrug micelle with blood-brain-barrier penetrability for anti-glioma therapy
Biomaterials (IF 10.273) Pub Date : 2019-12-03 ,DOI:10.1016/j.biomaterials.2019.119666
Various obstacles impede the chemotherapy efficiency of glioma in clinic, such as blood brain barrier (BBB) and blood brain tumor barrier (BBTB). Ligand-mediated polymeric micelles have shown great potential for improving the efficiency of glioma treatment. Herein, we developed a disulfide bond-conjugated prodrug polymer consisted of camptothecin (CPT) and polyethylene glycol (PEG) with further modification of iRGD peptide. The polymer of CPT-S-S-PEG-COOH could self-assemble into nanosized polymeric micelles with diameter around 100 nm, and loaded with photosensitizer IR780 for combination therapy. The micelles displayed good stability with controlled drug release under physiological environment. Importantly, the iRGD modified polymeric micelles demonstrated favorable ability to cross the BBB and target glioma cells via αv β integrin and neuropilin-1-mediated ligand transportation in vitro and in vivo. The whole synthesis process is simple and the drug loading content of CPT in the CPT-S-S-PEG-iRGD@IR780 micelles was higher than 10%. Moreover, CPT-S-S-PEG-iRGD@IR780 micelles combined chemotherapy with photodynamic therapy (PDT) displayed more excellent tumor-killing capability than the other groups. Thus, both in vitro and in vivo studies suggested that the targeting prodrug system could not only effectively cross various barriers to reach at glioma site, but also significantly enhance the antitumor effect with laser irradiation. Our findings consequently suggested that CPT-S-S-PEG-iRGD@IR780 micelles with laser irradiation are a promising drug delivery system for glioma therapy. ...
Co-encapsulation of synthetic lipidated TLR4 and TLR7/8 agonists in the liposomal bilayer results in a rapid, synergistic enhancement of vaccine-mediated humoral immunity
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-22 ,DOI:10.1016/j.jconrel.2019.10.025
Further, co-encapsulated formulations give significant improvement of early IgG2a antibody titers in BALB/c mice following primary vaccination when compared to single agonist or dual agonists delivered in separate liposomes. ...
Local inflammation alters the lung disposition of a drug loaded pegylated liposome after pulmonary dosing to rats
Journal of Controlled Release (IF 7.901) Pub Date : 2019-05-29 ,DOI:10.1016/j.jconrel.2019.05.043
Liposomes were initially cleared more rapidly from inflamed lungs than from healthy lungs, but exhibited similar rates of lung clearance after 3 days. ...
Triple-functional polyetheretherketone surface with enhanced bacteriostasis and anti-inflammatory and osseointegrative properties for implant application
Biomaterials (IF 10.273) Pub Date : 2019-05-11 ,DOI:10.1016/j.biomaterials.2019.05.014
We previously developed a facile and versatile surface modification method using dexamethasone plus minocycline-loaded liposomes (Dex/Mino liposomes) bonded by a mussel-inspired polydopamine coating, which effectively modulated cell inflammatory response and discouraged bacterial colonization in vitro ...
Correction to pH-Controlled Liposomes for Enhanced Cell Penetration in Tumor Environment
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-05 ,DOI:10.1021/acsami.9b12730
Perfluoroheptane‐Loaded Hollow Gold Nanoshells Reduce Nanobubble Threshold Flux
Small (IF 10.856) Pub Date : 2019-01-17 ,DOI:10.1002/smll.201804476
The perfluoroheptane‐containing HGN can be linked via thiol–PEG–lipid tethers to carboxyfluorescein‐containing liposomes and shows a similar decreased flux necessary for liposome contents release. ...
Tumor-derived nanovesicles promote lung distribution of the therapeutic nanovector through repression of Kupffer cell-mediated phagocytosis.
Theranostics (IF 8.063) Pub Date : 2019-05-28 ,DOI:10.7150/thno.32363
The effect of ENVs pretreatment on anti-lung metastasis therapeutic effects of chemotherapeutic drugs delivered by DOTAP/DOPE liposomes in breast cancer-bearing mice was also examined. ...
Sub-cytotoxic doses of pharmaceutical silica nanoparticles show significant impact on the proteome of HepG2 cells
Journal of Controlled Release (IF 7.901) Pub Date : 2019-05-23 ,DOI:10.1016/j.jconrel.2019.05.033
SiO2NPs (free in cytoplasm) caused extensive changes in the proteome, whereas liposomes(compartmentalized) seemed unproblematic as they accounted for minimal changes in the protein profile. ...
Combining activatable nanodelivery with immunotherapy in a murine breast cancer model
Journal of Controlled Release (IF 7.901) Pub Date : 2019-04-09 ,DOI:10.1016/j.jconrel.2019.04.008
Following intravenous injection, local activation of the liposomes within a single tumor released doxorubicin and enhanced cross-presentation of a model antigen at distant tumor sites. ...
Ultrasound-activated microbubbles as a novel intracellular drug delivery system for urinary tract infection
Journal of Controlled Release (IF 7.901) Pub Date : 2019-03-20 ,DOI:10.1016/j.jconrel.2019.03.017
The gas-filled lipid microbubbles were decorated with liposomes containing the non-cell-permeant antibiotic gentamicin and a fluorescent marker. ...
Dual-drug loaded micelle for combinatorial therapy targeting HIF and mTOR signaling pathways for ovarian cancer treatment
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-28 ,DOI:10.1016/j.jconrel.2019.06.036
Mutations in the tumor protein (TP53) and the mammalian target of rapamycin (mTOR) pathway have been elucidated as driver mutations in ovarian carcinomas that transform into an invasive phenotype under hypoxic conditions. Chetomin (CHE) targets the hypoxic pathway while Everolimus (EVR) acts on the mTOR pathway. Poor aqueous solubilities of both compounds limit their clinical applications. Diblock copolymer nanoplatforms of methoxy poly(ethylene glycol)2000-block-poly (lactic acid)1800 (mPEG2000-b-PLA1800) and (mPEG4000-b-PLA2200) were used to formulate individual and dual drug loaded micelles (DDM) using the solvent evaporation method. The CHE micelles (CHE-M) had a size of 21 nm with CHE loading of 0.5 mg/mL while the EVR micelles (EVR-M) and the DDM had a size around 35 and 39 nm, respectively, with EVR loading up to 2.3 mg/mL. The anti-proliferative effects of these micelles have been tested in vitro in three ovarian cell lines (ES2, OVCAR3 and TOV21G) with the DDM exhibiting a strong synergistic anti-proliferative effect in the ES2 and the TOV21G cells. The DDM were able to significantly induce tumor regression in ES2 ovarian xenograft mouse models by inhibiting angiogenesis and inducing apoptosis when compared to the individual micelles. The inhibition of hypoxia inducible factor (HIF) and the mTOR pathways has been elucidated using immunohistochemistry studies. In conclusion, we have developed a mPEG-b-PLA based micellar nanoplatform that could prevent drug resistance by delivering multiple drugs at therapeutically relevant concentrations for effectively treating ovarian carcinomas. ...
Avidity and Cell Uptake of Integrin-Targeting Polypeptide Micelles is Strongly Shape-Dependent
Nano Letters (IF 12.279) Pub Date : 2019-08-12 ,DOI:10.1021/acs.nanolett.9b02095
We describe a genetically encoded micelle for targeted delivery consisting of a diblock polypeptide with segments derived from repetitive protein motifs inspired by Drosophila melanogaster Rec-1 resilin and human tropoelastin with a C-terminal fusion of an integrin-targeting fibronectin type III domain ...
Molecular Modeling: Modeling Interactions between Liposomes and Hydrophobic Nanosheets (Small 6/2019)
Small (IF 10.856) Pub Date : 2019-02-08 ,DOI:10.1002/smll.201970034
Although 2D nanomaterials have shown promising biomedical applications, their sharp edges and hydrophobic interaction with phospholipids could wreak havoc with cell membranes. In article number 1804992, Jun Fan and co‐workers investigate molecular insights into the interaction between hydrophobic nanosheets and lipid membranes using molecular dynamics simulations. Many molecule motions and thermodynamics are revealed, expanding knowledge of the behavior of 2D nanomaterials in biosystems. ...
Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of imperialine
Journal of Controlled Release (IF 7.901) Pub Date : 2019-09-01 ,DOI:10.1016/j.jconrel.2019.08.037
First, we introduced a novel micelle-aided method to efficiently load imperialine into intact ELVs. Then, integrin α3β1-binding octapeptide cNGQGEQc was modified onto ELV platform for tumor targeting as integrin α3β1 is overexpressed on NSCLC cells. ...
Thermoresponsive nanoemulsion-based gel synthesized through a low-energy process
Nature Communications (IF 11.878) Pub Date : 2019-06-21 ,DOI:10.1038/s41467-019-10749-1
We propose a gelation mechanism triggered by synergistic action of thermally-induced adsorption of Pluronic copolymers onto the droplet interface and an increased micelle concentration in the aqueous solution. ...
Single-molecule detection on a portable 3D-printed microscope
Nature Communications (IF 11.878) Pub Date : 2019-12-11 ,DOI:10.1038/s41467-019-13617-0
This device performs single photon counting and fluorescence correlation spectroscopy (FCS) in a simple format and is widely applicable to the detection of single fluorophores, proteins, liposomes or bacteria. ...
Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases
Nature Communications (IF 11.878) Pub Date : 2019-04-30 ,DOI:10.1038/s41467-019-09852-0
In this study a rational designed micelle (CTA-Mic) consisting of α-tocopheryl hydrophobic core and on-site detachable polyethylene glycol-thiol shell is developed for effective liver deposition of BBR. ...
Dual-Responsive Size-Shrinking Nanocluster with Hierarchical Disassembly Capability for Improved Tumor Penetration and Therapeutic Efficacy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-13 ,DOI:10.1021/acsami.8b21580
The nanocluster (RPSPT@SNCs) could preferentially accumulate into tumor tissue and dissociate under extracellular matrix metalloproteinase-2 (MMP-2) to release small-sized micelle formulations (RPSPTs). ...
Stiffness and Membrane Anchor Density Modulate DNA-Nanospring-Induced Vesicle Tubulation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-21 ,DOI:10.1021/acsami.9b05401
To systematically analyze how structural stiffness and membrane affinity of DNA nanostructures affect the membrane remodeling outcome, here we build DNA-origami curls with varying thickness and amphipathic peptide density, and have them polymerize into nanosprings on the surface of liposomes. ...
Liposome and immune system interplay: Challenges and potentials
Journal of Controlled Release (IF 7.901) Pub Date : 2019-05-20 ,DOI:10.1016/j.jconrel.2019.05.030
On the other hand, immune targeted liposomes for immunotherapy and vaccination purposes could also be developed. ...
Salt-Triggered Release of Hydrophobic Agents from Polyelectrolyte Capsules Generated via One-Step Interfacial Multilevel and Multicomponent Assembly
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-04 ,DOI:10.1021/acsami.9b13888
In addition, hydrophobic domains assemblied by surfactants and PE-nanocrystal network supply transport pathway for oil to across hydrophilic shells and subsequently produce inverse micelle to carry oil into water. ...
Surface engineering of nanomaterials with phospholipid-polyethylene glycol-derived functional conjugates for molecular imaging and targeted therapy
Biomaterials (IF 10.273) Pub Date : 2019-11-21 ,DOI:10.1016/j.biomaterials.2019.119646
Targeting moieties including small-molecule ligands, peptides, proteins, and antibodies are generally conjugated onto PEGylated phospholipids to decorate liposomes, micelles, hybrid nanoparticles, nanocomplexes, and nanoemulsions for targeted delivery of diagnostic and therapeutic agents to diseased ...
Chirality Transfer in Coassembled Organogels Enabling Wide-Range Naked-Eye Enantiodifferentiation
ACS Nano (IF 13.903) Pub Date : 2019-10-01 ,DOI:10.1021/acsnano.9b06250
On this basis, the system becomes highly sensitive, enabling a naked-eye sensing toward the single enantiomer of a diverse series of chiral species (including axial, point, planar, and polymeric chirality) via gel-to-micelle transformation, due to the asymmetric interaction hampering the chirality transfer ...
Detection of tBid Oligomerization and Membrane Permeabilization by Graphene-Based Single-Molecule Surface-Induced Fluorescence Attenuation
Nano Letters (IF 12.279) Pub Date : 2019-09-30 ,DOI:10.1021/acs.nanolett.9b02223
In oligomerized tBid clusters, α6 and α7 prefer to float up, and the other helices may sink to the bottom of the membrane and cause the formation of transient two-dimensional, micelle-like pore structures, which are responsible for the permeabilization of membranes and the induction of apoptosis. ...
ROS‐Sensitive Degradable PEG–PCL–PEG Micellar Thermogel
Small (IF 10.856) Pub Date : 2019-09-16 ,DOI:10.1002/smll.201903045
The micelle‐based thermogel of PEG–PCL–PEG with ROS‐triggering degradability is a promising injectable material for biomedical applications. ...
Molecular Programming of Biodegradable Nanoworms via Ionically Induced Morphology Switch toward Asymmetric Therapeutic Carriers
Small (IF 10.856) Pub Date : 2019-08-05 ,DOI:10.1002/smll.201901849
This ionically‐induced switch is driven by modulation of chain packing with salts screening interchain repulsions, leading to micelle elongation. ...
Metformin and Docosahexaenoic Acid Hybrid Micelles for Premetastatic Niche Modulation and Tumor Metastasis Suppression
Nano Letters (IF 12.279) Pub Date : 2019-04-30 ,DOI:10.1021/acs.nanolett.9b00495
Here this study reports a premetastatic niche-targeting micelle for the modulation of premetastatic microenvironments and suppression of tumor metastasis. ...
The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo
Journal of Controlled Release (IF 7.901) Pub Date : 2019-03-30 ,DOI:10.1016/j.jconrel.2019.03.028
Fatty acid valency significantly altered the physicochemical properties of conjugated siRNAs, including hydrophobicity and micelle formation, which affected distribution. ...
Micellar Formulation of Talazoparib and Buparlisib for Enhanced DNA Damage in Breast Cancer Chemoradiotherapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-21 ,DOI:10.1021/acsami.9b02408
Here, a monodisperse sub-20 nm mixed poloxamer micelle (MPM) system was developed to deliver hydrophobic drugs intravenously, in tandem with ionizing radiation. ...
Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles
Nature Communications (IF 11.878) Pub Date : 2019-07-25 ,DOI:10.1038/s41467-019-11235-4
Of note, this bLP-mediated TSM-remodeling to enhance cancer cell accessibility (TECA) strategy produces an eminent suppression of tumor growth and results in a 97.4% inhibition of lung metastasis, which is superior to the counterpart liposomes. ...
Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin
Nature Communications (IF 11.878) Pub Date : 2019-04-26 ,DOI:10.1038/s41467-019-09890-8
We also identify conformational changes that accompany membrane pore formation by visualising YenTcA inserted into liposomes. A clear outward rotation of the Chi1 subunits allows for access of the protruding translocation pore to the membrane. ...
Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome.
Nature Communications (IF 11.878) Pub Date : 2019-Jan-1 ,DOI:10.1038/s41467-018-08138-1
In contrast, liposomes containing a decoy receptor show weak antiviral activity due to the lack of membrane disruption. The nanodiscs inhibit influenza virus infection and reduce morbidity and mortality in a mouse model. ...
Smart Unimolecular Micelle-Based Polyprodrug with Dual-Redox Stimuli Response for Tumor Microenvironment: Enhanced in Vivo Delivery Efficiency and Tumor Penetration
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-18 ,DOI:10.1021/acsami.9b13214
Low delivery efficiency and limited tumor penetration of nanoparticle-based drug delivery systems (DDSs), the two most concerned issues in tumor therapy, have been considered as the “Achilles’ heel” for tumor treatment. In this study, we have designed a highly sensitive dual-redox-responsive prodrug-based starlike polymer β-CD-b-P(CPTGSH-co-CPTROS-co-OEGMA) (CPGR) for synergistic chemotherapy. The high glutathione (GSH) concentration and high reactive oxygen species (ROS) levels are in a dynamic equilibrium in the tumor microenvironment (TME) and could trigger the disintegration of CPGR micelles, which can promote the release of anticancer drug camptothecin (CPT) completely and intelligently. In order to verify the synergistic antitumor mechanism, two corresponding single-responsive β-CD-b-P(CPTGSH-co-OEGMA) (CPG) and β-CD-b-P(CPTROS-co-OEGMA) (CPR) were altogether prepared as contrast. Both in vitro and in vivo studies confirmed the enhanced anticancer activity of CPGR micelles in comparison of single responsive micelles. This work contributes to the orchestrated design of dual-redox-responsive DDSs for synergetic antitumor chemotherapy, which provides a good approach for the development of dual-redox-responsive nanomedicine. ...
Dendritic Cell-Activating Magnetic Nanoparticles Enable Early Prediction of Antitumor Response with Magnetic Resonance Imaging
ACS Nano (IF 13.903) Pub Date : 2019-12-02 ,DOI:10.1021/acsnano.9b05037
Here, we design multifunctional RNA-loaded magnetic liposomes to initiate potent antitumor immunity and function as an early biomarker of treatment response. ...
De novo synthesized Min proteins drive oscillatory liposome deformation and regulate FtsA-FtsZ cytoskeletal patterns
Nature Communications (IF 11.878) Pub Date : 2019-10-31 ,DOI:10.1038/s41467-019-12932-w
Here, the MinD and MinE proteins are synthesized de novo from their genes inside liposomes. Dynamic protein patterns and accompanying liposome shape deformation are observed. ...
Membrane-Mimetic Dendrimersomes Engulf Living Bacteria via Endocytosis
Nano Letters (IF 12.279) Pub Date : 2019-07-18 ,DOI:10.1021/acs.nanolett.9b02349
Nonetheless, natural liposomes and synthetic polymersomes fail to sufficiently recapitulate membrane properties to perform this advanced function. Here we report the engulfment of living bacteria into endosomes by cell-like dendrimersomes assembled from Janus dendrimers. ...
Liposome-Enhanced Polymerization-Based Signal Amplification for Highly Sensitive Naked-Eye Biodetection in Paper-Based Sensors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-26 ,DOI:10.1021/acsami.9b08125
In this work, we demonstrated efficient localization of large quantities of eosin Y per captured target analyte by incorporating eosin Y-loaded liposomes into PBA. This new “materials approach” allowed 30-fold signal enhancement compared to conventional PBA. ...
Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues
Nature Communications (IF 11.878) Pub Date : 2019-05-27 ,DOI:10.1038/s41467-019-10271-4
DSF binding is associated with enhanced auto-phosphorylation of PA1396 incorporated into liposomes. Further, we examined the ability of synthetic DSF analogues to modulate or inhibit PA1396 activity. ...
Shape and Size Control of Artificial Cells for Bottom-Up Biology
ACS Nano (IF 13.903) Pub Date : 2019-05-16 ,DOI:10.1021/acsnano.9b00220
As encapsulation and controlled manipulation of these elements is a crucial step in the recreation of such cell-like objects, microfluidics is increasingly used for the production of minimal artificial containers such as single-emulsion droplets, double-emulsion droplets, and liposomes. ...
TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells
Nature Communications (IF 11.878) Pub Date : 2019-05-02 ,DOI:10.1038/s41467-019-10045-y
Here we show that transmembrane protein 33 (TMEM33) interacts with the ion channel polycystin-2 (PC2) at the endoplasmic reticulum (ER) membrane, enhancing its opening over the whole physiological calcium range in ER liposomes fused to planar bilayers. ...
Framework nucleic acids as programmable carrier for transdermal drug delivery
Nature Communications (IF 11.878) Pub Date : 2019-03-08 ,DOI:10.1038/s41467-019-09029-9
Employing a mouse melanoma model, topical application of doxorubicin-loaded FNAs accommodates ≥2-fold improvement in drug accumulation and tumor inhibition relative to topically-applied free doxorubicin, or doxorubicin loaded in liposomes and polymeric nanoparticles. ...
Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release
ACS Nano (IF 13.903) Pub Date : 2019-03-29 ,DOI:10.1021/acsnano.8b08246
UPSM undergo micelle–unimer phase transition at their apparent pKa, with dramatically increased buffer capacity in a narrow pH range (<0.3 pH). ...
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-10 ,DOI:10.1021/acsami.8b17808
We have found that micelle-forming PAs possess excellent antimicrobial activity against various Gram-positive and Gram-negative pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Klebsiella pneumoniae with minimal inhibitory concentrations (MICs) ranging between ...
Elimination of Intracellular Calcium Overload by BAPTA-AM-Loaded Liposomes: A Promising Therapeutic Agent for Acute Liver Failure
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-17 ,DOI:10.1021/acsami.9b13690
In the past few decades, intracellular calcium overload has been shown to induce cell death through multiple signaling pathways. In this study, we used BAPTA-AM, a well-known membrane-permeable Ca2+ chelator, to prevent cell injury by allaying the intracellular calcium overload. We explored the clinical potentials of BAPTA-AM-loaded liposome (BAL) in the treatment of the acute liver failure (ALF) mouse model, which is characterized by severe hepatic necrosis and apoptosis. We discovered that BAL can significantly inhibit D-GalN-induced LO2 cell damage as it increased cell viability by 60% and downregulated the LPS-stimulated inflammatory response in RAW 264.7 macrophages by reversing the morphological change and modulating TNF-α and NF-κB expressions. Through systemic administration, BAL can rapidly accumulate in damaged liver tissue and exhibit excellent treatment effects on the D-GalN/LPS-induced ALF mouse model, including elevation of the survival rate (from 10 to 80%), recovery of normal liver indexes and liver health indicators, improvement of liver blood microcirculation (increased the blood flow volume by 80% and flow rate by 60%), and blood coagulation. The underlying hepatoprotective effect of BAL is presumably based on the antinecrosis and antiapoptosis abilities attributed to its inhibition on oxidative stress, restriction on TNF-α receptor, and mitochondria-mediated apoptotic pathway by effectively clearing the overloaded intercellular calcium. BAL holds great potential as a new therapeutic strategy for ALF treatment, and its prominent cell rescue ability provides ample opportunities for the treatment of many other diseases that are characterized by rapid and massive cell damage. ...
Purified F-ATP synthase forms a Ca 2+ -dependent high-conductance channel matching the mitochondrial permeability transition pore
Nature Communications (IF 11.878) Pub Date : 2019-09-25 ,DOI:10.1038/s41467-019-12331-1
By combining highly purified, fully active bovine F-ATP synthase with preformed liposomes we show that Ca2+ dissipates the H+ gradient generated by ATP hydrolysis. After incorporation of the same preparation into planar lipid bilayers Ca2+ elicits currents matching those of the MMC/PTP. ...
Mitochondria-Responsive Drug Release along with Heat Shock Mediated by Multifunctional Glycolipid Micelles for Precise Cancer Chemo-Phototherapy.
Theranostics (IF 8.063) Pub Date : 2019-02-28 ,DOI:10.7150/thno.31022
Results: Specifically, upon laser irradiation, the photothermal conversion by IR780-CSOSA can not only weaken the hydrophobic interaction between the core of micelles and DOX and trigger unexpected micelle swelling to release DOX in mitochondria for the amplification of ROS, but also induce mitochondria-specific ...
Evaluation of polyvinylpyrrolidone and block copolymer micelle encapsulation of serine chlorin e6 and chlorin e4 on their reactivity towards albumin and transferrin and their cell uptake
Journal of Controlled Release (IF 7.901) Pub Date : 2019-11-02 ,DOI:10.1016/j.jconrel.2019.10.010
Encapsulation of porphyrinic photosensitizers (PSs) into polymeric carriers plays an important role in enhancing their efficiency as drugs in photodynamic therapy (PDT). Porphyrin aggregation and low solubility as well as the preservation of the advantageous photophysical properties pose a challenge on the design of efficient PS-carrier systems. Block copolymer micelles (BCMs) and polyvinylpyrrolidone (PVP) are promising drug delivery vehicles for physical entrapment of PSs. BCMs exhibit enhanced dynamics as compared to the less flexible PVP network. In the current work the question is addressed how these different dynamics affect PS encapsulation, release from the carrier, reaction with serum proteins, and cellular uptake. The porphyrinic compounds serine-amide of chlorin e6 (SerCE) and chlorin e4 (CE4) were used as model PSs with different lipophilicity and aggregation properties. 1H NMR and fluorescence spectroscopy were applied to study their interactions with PVP and BCMs consisting of Kolliphor P188 (KP). Both chlorins were well encapsulated by the carriers and had improved photophysical properties. Compared to SerCE, the more lipophilic CE4 exhibited stronger hydrophobic interactions with the BCM core, stabilizing the system and preventing exchange with the surrounding medium as was shown by NMR NOESY and DOSY experiments. PVP and BCMs protected the encapsulated chlorins against interaction with human transferrin (Tf). However, SerCE and CE4 were released from BCMs in favor of binding to human serum albumin (HSA) while PVP prevented interaction with HSA. Fluorescence spectroscopic studies revealed that HSA binds to the surface of PVP forming a protein corona. PVP and BCMs reduced cellular uptake of the chlorins. However, encapsulation into BCMs resulted in more efficient cell internalization for CE4 than for SerCE. HSA significantly lowered both, free and carrier-mediated cell uptake for CE4 and SerCE. In conclusion, PVP appears as the more universal delivery system covering a broad range of host molecules with respect to polarity, whereas BCMs require a higher drug-carrier compatibility. Poorly soluble hydrophobic PSs benefit stronger from BCM-type carriers due to enhanced bioavailability through disaggregation and solubilization allowing for more efficient cell uptake. In addition, increased PS-carrier hydrophobic interactions have a stabilizing effect. For more hydrophilic PSs, the main advantage of polymeric carriers like PVP or poloxamer micelles lies in their protection during the transport through the bloodstream. HSA binding plays an important role for drug release and cell uptake in carrier-mediated delivery to the target tissue. ...
Fabrication of an Aptamer-Coated Liposome Complex for the Detection and Profiling of Exosomes Based on Terminal Deoxynucleotidyl Transferase-Mediated Signal Amplification
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-30 ,DOI:10.1021/acsami.9b18869
Specifically, in the presence of target exosomes, the aptamers immobilized on the surface of 1,2-dioleoyl-3-trimethylammonium-propane liposomes prefer to bind with exosomal membrane proteins due to the high affinity. ...
Tetrazine-Mediated Bioorthogonal System for Prodrug Activation, Photothermal Therapy, and Optoacoustic Imaging
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-31 ,DOI:10.1021/acsami.9b13374
The trigger of the system was fabricated by immobilizing PEGylated tetrazine on the gold nanorods, and the bioorthogonal prodrug was synthesized by caging the drug camptothecin with vinyl ether, followed by encapsulating it with phospholipid liposomes. ...
The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1
Nature Communications (IF 11.878) Pub Date : 2019-09-19 ,DOI:10.1038/s41467-019-12279-2
We next solve the 3.6 Å cryo-EM structure of MPEG1 in complex with liposomes. These data reveal that a multi-vesicular body of 12 kDa (MVB12)-associated β-prism (MABP) domain binds membranes such that the pore-forming machinery of MPEG1 is oriented away from the bound membrane. ...
Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
Nature Communications (IF 11.878) Pub Date : 2019-05-02 ,DOI:10.1038/s41467-019-09760-3
All components of the nanosonosensitizers (HMME/R837@Lip) are clinically approved, wherein liposomes act as carriers to co-encapsulate sonosensitizers (hematoporphyrin monomethyl ether (HMME)) and immune adjuvant (imiquimod (R837)). ...
Tyrosinase-Loaded Multicompartment Microreactor toward Melanoma Depletion
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-15 ,DOI:10.1021/acsami.8b20275
Herein, a multicompartment carrier consisting of a polymer shell entrapping thousands of liposomes is employed to act as a microreactor depleting l-tyr in the presence of melanoma cells. ...
Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis
Journal of Controlled Release (IF 7.901) Pub Date : 2019-01-02 ,DOI:10.1016/j.jconrel.2018.12.049
Besides, the use of lipid-based nanosystems, such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), liposomes, nanoemulsions and microemulsions, have been demonstrating high efficiency for nose-to-brain transport. ...
Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction.
Theranostics (IF 8.063) Pub Date : 2019-06-01 ,DOI:10.7150/thno.29945
The RNase resistant rate of miR21-EVs was calculated by real-time PCR and compared with liposomesand polyethylenimine (PEI). ...
Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7
Nature Communications (IF 11.878) Pub Date : 2019-10-18 ,DOI:10.1038/s41467-019-12738-w
Super-resolution microscopy reveals the similar assemblies of GAS7 on phagocytic cups and liposomes. The mutations of the loops abolishes both the membrane localization of GAS7 and phagocytosis. Thus, the sheet-like assembly of GAS7 plays a significant role in phagocytosis. ...
Predicting Drug Release Kinetics from Nanocarriers inside Dialysis Bags
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-16 ,DOI:10.1016/j.jconrel.2019.09.016
The model was tested on DOXIL® (doxorubicin liposomes), and an excellent agreement was found between the predicted and measured drug concentration inside the dialysis membranes. ...
Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors
ACS Nano (IF 13.903) Pub Date : 2019-09-20 ,DOI:10.1021/acsnano.9b02395
PDAC tumors, pretreated with the collagozome followed by paclitaxel micelles, were 87% smaller than tumors pretreated with empty liposomes followed by paclitaxel micelles. Interestingly, degrading the ECM did not increase the number of circulating tumor cells or metastasis. ...
Nanoparticle-mediated internal radioisotope therapy to locally increase the tumor vasculature permeability for synergistically improved cancer therapies
Biomaterials (IF 10.273) Pub Date : 2019-01-21 ,DOI:10.1016/j.biomaterials.2019.01.033
Via a convenient method, a therapeutic radioisotope iodine-131 is labeled onto albumin-encapsulated liposomes with greatly improved radiolabeling stability compared to 131I labeled albumin. ...
Combinational protective therapy for spinal cord injury medicated by sialic acid-driven and polyethylene glycol based micelles
Biomaterials (IF 10.273) Pub Date : 2019-07-01 ,DOI:10.1016/j.biomaterials.2019.119326
The obtained SAPP copolymer could self-assemble into micelles with critical micelle concentration being of 13.40 μg/mL, and effectively encapsulate hydrophobic minocycline. ...
PEGylation of Paclitaxel-Loaded Cationic Liposomes Drives Steric Stabilization of Bicelles and Vesicles thereby Enhancing Delivery and Cytotoxicity to Human Cancer Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-24 ,DOI:10.1021/acsami.9b16150
Poly(ethylene glycol) (PEG) is a polymer used widely in drug delivery to create “stealth” nanoparticles (NPs); PEG coatings suppress NP detection and clearance by the immune system and beneficially increase NP circulation time in vivo. However, NP PEGylation typically obstructs cell attachment and uptake in vitro compared to the uncoated equivalent. Here, we report on a cationic liposome (CL) NP system loaded with the hydrophobic cancer drug paclitaxel (PTX) in which PEGylation (i.e., PEG-CLPTX NPs) unexpectedly enhances, rather than diminishes, delivery efficacy and cytotoxicity to human cancer cells. This highly unexpected enhancement occurs even when the PEG-chains coating the NP are in the transition regime between the mushroom and brush conformations. Cryogenic transmission electron microscopy (TEM) of PEG-CLPTX NPs shows that PEG causes the proliferation of a mixture of sterically stabilized nanometer-scale vesicles and anisotropic micelles (e.g., bicelles). Remarkably, the onset of bicelles at sub-monolayer concentrations of the PEG coat has to our knowledge not been previously reported; it was previously thought that PEG-lipid in this composition regime was incorporated into vesicles but did not alter their shape. Confocal microscopy and flow cytometry reveal significantly greater PTX cell uptake from stabilized PEG-CLPTX NPs (vesicles and bicelles) in contrast to bare CLPTX NPs, which can aggregate in cell medium. This underscores the ability of steric stabilization to facilitate NP entry into cells via distinct size-dependent endocytic pathways, some of which cannot transport large NP aggregates into cells. This study highlights the value of understanding how PEGylation alters NP shape and structure, and thus NP efficacy, to design next-generation stealth drug carriers that integrate active cell-targeting strategies into NPs for in vivo delivery. ...
Corona Composition Can Affect the Mechanisms Cells Use to Internalize Nanoparticles
ACS Nano (IF 13.903) Pub Date : 2019-09-23 ,DOI:10.1021/acsnano.9b03824
Similar studies were performed using other cells, including A549 cells and primary HUVEC, and different nanoparticles, namely 100 nm liposomes and 200 nm silica. Overall, the results confirmed that the corona composition can affect the mechanisms of nanoparticle uptake by cells. ...
Liposome-Encapsulated Curcumin-Loaded 3D Printed Scaffold for Bone Tissue Engineering
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-01 ,DOI:10.1021/acsami.9b01218
Upon successful encapsulation of curcumin into the liposomes, we have investigated the effect of liposomal curcumin released from the 3DP scaffolds on both human fetal osteoblast cells (hFOB) and human osteosarcoma (MG-63) cells. ...
Nanotechnology-mediated immunochemotherapy with Ingenol-3-Mebutate for Systematic Anti-tumor Effects
Journal of Controlled Release (IF 7.901) Pub Date : 2019-05-06 ,DOI:10.1016/j.jconrel.2019.05.007
Herein we developed a polymeric micelle with ‘acidic core’ provided by single alcoholic hydroxyl (-CH(CH3)-OH) encapsulating I3A (I3A-PM), which successfully overcome the aforementioned problems and reduce the toxicity in vivo. ...
PEG-Detachable Polymeric Micelles Self-Assembled from Amphiphilic Copolymers for Tumor-Acidity-Triggered Drug Delivery and Controlled Release
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-29 ,DOI:10.1021/acsami.8b13059
Overall, we anticipate that this PEG-detachable and tumor-acidity-responsive polymeric micelle can mediate effective and biocompatible drug delivery “on demand” with clinical application potential. ...
Defeating relapsed and refractory malignancies through a nano-enabled mitochondria-mediated respiratory inhibition and damage pathway
Biomaterials (IF 10.273) Pub Date : 2019-10-31 ,DOI:10.1016/j.biomaterials.2019.119580
Specifically, a novel photosensitizers (IR780) and metformin are packaged in PEG-PCL liposomes. Once such nanoparticles accumulated in tumor tissues, the tumor foci were irradiated through 808 nm laser, generated ROS to further release metformin and IR780. ...
Engineering temperature-sensitive plateletsomes as a tailored chemotherapy platform in combination with HIFU ablation for cancer treatment
Theranostics (IF 8.063) Pub Date : 2019-05-31 ,DOI:10.7150/thno.32172
The targeting performance, pharmacokinetic behavior and therapeutic potential of TSPs in combination with HIFU ablation were evaluated using HeLa cells and a HeLa cell tumor-bearing nude mouse model in comparison with temperature-sensitive liposomes (TSLs). ...
A Biomimetic Hierarchical Nanointerface Orchestrates Macrophage Polarization and Mesenchymal Stem Cell Recruitment To Promote Endogenous Bone Regeneration
ACS Nano (IF 13.903) Pub Date : 2019-05-31 ,DOI:10.1021/acsnano.9b00489
The depletion of monocyte/macrophages by clodronate liposomes significantly impaired bone regeneration by HIMC, but did not affect MSC recruitment. ...
Sequential Intercellular Delivery Nanosystem for Enhancing ROS-Induced Antitumor Therapy
Nano Letters (IF 12.279) Pub Date : 2019-05-02 ,DOI:10.1021/acs.nanolett.9b00336
To address these limitations, herein we constructed a sequential intercellular delivery system (MFLs/LAOOH@DOX) that consists of a membrane fusion liposomes (MFLs) doped with linoleic acid hydroperoxide (LAOOH) in the lipid bilayer and antitumor doxorubicin (DOX) encapsulated inside. ...
Pharmacokinetics and pharmacodynamics of liposomal chemophototherapy with short drug-light intervals
Journal of Controlled Release (IF 7.901) Pub Date : 2019-01-23 ,DOI:10.1016/j.jconrel.2019.01.030
Long-circulating, sterically-stabilized liposomes loaded with doxorubicin (Dox) stably incorporate small amounts of a porphyrin-phospholipid (PoP) photosensitizer in the bilayer. These were administered intravenously to mice bearing low-passage, patient-derived pancreatic cancer xenografts (PDX). ...
Carrier-Enhanced Anticancer Efficacy of Sunitinib-Loaded Green Tea-Based Micellar Nanocomplex beyond Tumor-Targeted Delivery
ACS Nano (IF 13.903) Pub Date : 2019-07-08 ,DOI:10.1021/acsnano.9b00467
In comparison, a conventional nanocarrier, SU-loaded polymeric micelle (SU-PM) comprised of PEG-b-poly(lactic acid) (PEG-PLA) copolymer, only reduced toxicity with no elevated efficacy, despite comparable drug-loading and tumor-targeting efficiency to SU-MNC. ...
Near-Infrared II Phototherapy Induces Deep Tissue Immunogenic Cell Death and Potentiates Cancer Immunotherapy
ACS Nano (IF 13.903) Pub Date : 2019-09-30 ,DOI:10.1021/acsnano.9b06040
Specifically, photothermal transducers with similar components, structures, and photothermal conversion efficiencies, but different absorptions in red light, NIR(I), and NIR(II) biowindows, were constructed by controlling the self-assembly of gold nanoparticles on fluidic liposomes. ...
The trip of a drug inside the body: From a lipid-based nanocarrier to a target cell
Journal of Controlled Release (IF 7.901) Pub Date : 2019-07-21 ,DOI:10.1016/j.jconrel.2019.07.027
This gap in the literature motivated us to present the current opinion paper, in which drug physicochemical properties like drug lipophilicity/hydrophilicity is considered as an important element in designing drug-carrying liposomes or micelles. ...
Heat-activated drug delivery increases tumor accumulation of synergistic chemotherapies
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-11 ,DOI:10.1016/j.jconrel.2019.06.012
In vivo measurements demonstrated effective heat-mediated triggering of doxorubicin and alvespimycin release from thermosensitive liposomes within tumor vasculature. ...
Effects of cationic adjuvant formulation particle type, fluidity and immunomodulators on delivery and immunogenicity of saRNA
Journal of Controlled Release (IF 7.901) Pub Date : 2019-05-06 ,DOI:10.1016/j.jconrel.2019.04.043
We observed that while the fluid phase liposome formulations showed the highest in vitro transfection efficiency, the fluid and solid phase liposomes had equivalent luciferase expression in vivo. ...
Prevention of paclitaxel-induced neuropathy by formulation approach
Journal of Controlled Release (IF 7.901) Pub Date : 2019-04-11 ,DOI:10.1016/j.jconrel.2019.04.013
PEGylated liposomes containing paclitaxel were successfully developed and demonstrated reduced neurotoxicity in-vitro in neuronal cells and prevented development of peripheral neuropathy in-vivo. ...
Interaction of Laponite with Membrane Components—Consequences for Bacterial Aggregation and Infection Confinement
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-17 ,DOI:10.1021/acsami.9b03527
Despite their net positive charge, peptide-loaded Laponite nanoparticles did not kill Gram-negative Escherichia coli bacteria or disrupt anionic model liposomes. They did however cause bacteria flocculation, originating from the interaction of Laponite and bacterial lipopolysaccharide (LPS). ...
Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1α Inhibitor Impairs Pancreatic Tumor Growth
ACS Nano (IF 13.903) Pub Date : 2019-01-28 ,DOI:10.1021/acsnano.8b08823
We then employed transferrin receptor 1 (TFR1) targeting liposomes to codeliver DFO and YC1 to pancreatic tumors in a mouse model. ...
Charge-Selective Delivery of Proteins Using Mesoporous Silica Nanoparticles Fused with Lipid Bilayers
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-16 ,DOI:10.1021/acsami.8b15390
The protein-loaded MSNs were fused with liposomes to form a protocell-like delivery system (MSN-LP) in order to prevent burst release of proteins. ...
Release of Fragrances from Cotton Functionalized with Carbohydrate-Binding Module Proteins
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-22 ,DOI:10.1021/acsami.9b08191
In approach 1, OBP fusion protein served as a fragrance container, whereas in approach 2, the fragrance was loaded into liposomes with a higher cargo capacity. The two strategies showed a differentiated β-citronellol release profile triggered by an acidic sweat solution. ...
Red Blood Cells-Derived Vesicles for Delivery of Lipophilic Drug Camptothecin
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-12 ,DOI:10.1021/acsami.9b04827
So far, these naturally derived nanoparticles show a significant overlap with liposomes in terms of stability, solute encapsulation, and release. ...
Threatening cancer with nanoparticle aided combination oncotherapy
Journal of Controlled Release (IF 7.901) Pub Date : 2019-03-16 ,DOI:10.1016/j.jconrel.2019.03.015
Various nano-delivery systems like liposomes, polymeric nanoparticles, polymerosomes, dendrimers, micelles, lipid based nanoparticles, prodrug based nanocarriers, polymer-drug conjugates, polymer-lipid hybrid nanoparticles, carbon nanotubes, nanosponges, supramolecular nanocarriers and inorganic nanoparticles ...
Mechanistic insights into the pH-dependent membrane peptide ATRAM
Journal of Controlled Release (IF 7.901) Pub Date : 2019-02-11 ,DOI:10.1016/j.jconrel.2019.02.010
We also show that ATRAM is able to be deliver liposomes to cells in a pH dependent way. Our data highlight the potential of ATRAM as a specific therapeutic agent for diseases that lead to acidic tissues, including cancer. ...
Knockdown of hypoxia-inducible factor-1 alpha by tumor targeted delivery of CRISPR/Cas9 system suppressed the metastasis of pancreatic cancer
Journal of Controlled Release (IF 7.901) Pub Date : 2019-05-14 ,DOI:10.1016/j.jconrel.2019.05.019
Compared with pegylated liposomes, R8-dGR-Lip enhanced the distribution in tumor tissues. The targeted delivery of CRISPR/Cas9-HIF-1α system and PTX significantly inhibited tumor growth. ...
Navigate-dock-activate anti-tumor strategy: Tumor micromilieu charge-switchable, hierarchically activated nanoplatform with ultrarapid tumor-tropic accumulation for trackable photothermal/chemotherapy.
Theranostics (IF 8.063) Pub Date : 2019-05-28 ,DOI:10.7150/thno.33280
Methods: We engineered a lithocholic acid-conjugated disulfide-linked polyethyleneimine micelle(LAPMi) loaded with paclitaxel (LAPMi-PTX, L), followed by the electrostatic adsorption of indocyanine green (ICG, I) on LAPMI-PTX and subsequently coated them with thermosensitive DPPC and DSPE-PEG-NH2 lipids ...
Co-delivery of VEGF siRNA and Etoposide for Enhanced Anti-angiogenesis and Anti-proliferation Effect via Multi-functional Nanoparticles for Orthotopic Non-Small Cell Lung Cancer Treatment.
Theranostics (IF 8.063) Pub Date : 2019-09-20 ,DOI:10.7150/thno.32416
These NPs consisted of cationic liposomes loaded with siVEGF and ETO and then coated with versatile polymer PEGylated histidine-grafted chitosan-lipoic acid (PHCL). ...
The first integrins β3-mediated cellular and nuclear targeting therapeutics for prostate cancer
Biomaterials (IF 10.273) Pub Date : 2019-09-04 ,DOI:10.1016/j.biomaterials.2019.119471
Most importantly, B3int-modified liposomes (B3int-LS-DOX) can selectively deliver DOX not only into prostate cancer cells, but into nucleus via targeting integrins β3, thereby significantly improving anticancer effects in 2D prostate cancer cells and 3D tumor spheroids. ...
Poly(ethylene glycol)-block-poly(d,l-lactic acid) micelles containing oligo(lactic acid)8-paclitaxel prodrug: In Vivo conversion and antitumor efficacy
Journal of Controlled Release (IF 7.901) Pub Date : 2019-02-18 ,DOI:10.1016/j.jconrel.2019.02.017
Poly(ethylene glycol)-block-poly(d,l-lactic acid) (PEG-b-PLA) micelles affect drug solubilization, and a paclitaxel (PTX) loaded-PEG-b-PLA micelle (PTX-PM) is approved for cancer treatment due to injection safety and dose escalation (Genexol-PM®) compares to Taxol®. ...
Glyco-Dendrimers as Intradermal Anti-Tumor Vaccine Targeting Multiple Skin DC Subsets.
Theranostics (IF 8.063) Pub Date : 2019-09-20 ,DOI:10.7150/thno.35059
Dual CLR targeting using a single tumor vaccine has been difficult, as we previously showed Langerin to favor binding and uptake of monovalent glyco-peptides whereas DC-SIGN favors binding of larger multivalent glyco-particles such as glyco-liposomes. ...
Enhanced cytotoxic T lymphocytes recruitment targeting tumor vasculatures by endoglin aptamer and IP-10 plasmid presenting liposome-based nanocarriers.
Theranostics (IF 8.063) Pub Date : 2019-07-10 ,DOI:10.7150/thno.33383
Xiaomei Yang,Jing Zhao,Siliang Duan,Xiaoqiong Hou,Xi Li,Zixi Hu,Zhuoran Tang,Fengzhen Mo,Xiaoling Lu


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