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2019年生物纳米研究最新热点报道(五)
来源于:纳米医学网 | 作者: | 发布时间:2017-12-31 | 浏览:341



Sandwich-Like Nanofibrous Scaffolds for Bone Tissue Regeneration
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-05 ,DOI:10.1021/acsami.9b06359
In conclusion, the developed scaffolds could be a promising solution to stimulate bone regeneration. ...
A new class of biological materials: Cell membrane-derived hydrogel scaffolds
Biomaterials (IF 10.273) Pub Date : 2019-01-11 ,DOI:10.1016/j.biomaterials.2019.01.020
There are also higher percentages of macrophages presenting immunosuppressive PD-L1 in RBCM-scaffolds than in MA-alginate scaffolds. Interestingly, the concentrations of anti-inflammatory cytokine, IL-10 in both types of scaffolds are higher than those in normal organ tissues. ...
Three-Dimensional Porous Scaffolds with Biomimetic Microarchitecture and Bioactivity for Cartilage Tissue Engineering
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-24 ,DOI:10.1021/acsami.9b12206
In vitro experiments demonstrated that all scaffolds had good biocompatibility, but the chondrocyte proliferation rate of the composite NF/DCECM scaffolds was higher than that of the NF scaffolds. ...
Controlling the Multiscale Structure of Nanofibrous Fibrinogen Scaffolds for Wound Healing
Nano Letters (IF 12.279) Pub Date : 2019-08-23 ,DOI:10.1021/acs.nanolett.9b02798
Toward novel scaffolds for wound healing, which are stable in aqueous environment, we also introduced cross-linking of fibrinogen scaffolds in formaldehyde vapor. ...
Active generation of nanoholes in DNA origami scaffolds for programmed catalysis in nanocavities
Nature Communications (IF 11.878) Pub Date : 2019-10-31 ,DOI:10.1038/s41467-019-12933-9
DNA origami tiles provide nanostructures for the spatial and temporal control of functional loads on the scaffolds. ...
Grape Seed-Inspired Smart Hydrogel Scaffolds for Melanoma Therapy and Wound Healing
ACS Nano (IF 13.903) Pub Date : 2019-04-03 ,DOI:10.1021/acsnano.8b09496
Inspired by grape-seed extracts, OPC were explored as a photothermal agent and endowed the hydrogel scaffolds with excellent and controlled photothermal ability. The rheological property of the hydrogel scaffolds responded to irradiation time of near infrared (NIR) laser, and OPC contents. ...
Hierarchically Designed Bone Scaffolds: From Internal Cues to External Stimuli
Biomaterials (IF 10.273) Pub Date : 2019-07-03 ,DOI:10.1016/j.biomaterials.2019.119334
This review summarizes recent advances within the field in utilizing these features of native bone to guide the hierarchical design of materials and scaffolds. ...
In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration
Nature Communications (IF 11.878) Pub Date : 2019-10-11 ,DOI:10.1038/s41467-019-12545-3
Implanted scaffolds with inductive niches can facilitate the recruitment and differentiation of host cells, thereby enhancing endogenous tissue regeneration. ...
Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications
Biomaterials (IF 10.273) Pub Date : 2019-12-23 ,DOI:10.1016/j.biomaterials.2019.119706
Scaffolds usually are used as implants to supply certain mechanical supporting to the defective area or utilized as diagnosis and imaging methods. But, in general, unmodified scaffolds show limited abilities in promoting tissue regeneration and treating diseases. ...
Gold Nanoparticle-Integrated Scaffolds for Tissue Engineering and Regenerative Medicine
Nano Letters (IF 12.279) Pub Date : 2019-03-20 ,DOI:10.1021/acs.nanolett.9b00472
We further describe using gold nanoparticle-integrated scaffolds to achieve improved stem cells proliferation and differentiation. Finally, we discuss the main challenges and prospects for clinical translation of gold nanoparticles-hybrid scaffolds. ...
Biologically Inspired Scaffolds for Heart Valve Tissue Engineering via Melt Electrowriting
Small (IF 10.856) Pub Date : 2019-05-06 ,DOI:10.1002/smll.201900873
Scaffolds with precisely‐defined serpentine architectures reproduce the J‐shaped strain stiffening, anisotropic and viscoelastic behavior of native heart valve leaflets, as demonstrated by quasistatic and dynamic mechanical characterization. ...
Enzymatically Cross-Linked Silk Fibroin-Based Hierarchical Scaffolds for Osteochondral Regeneration
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-16 ,DOI:10.1021/acsami.8b21259
A homogeneous porosity distribution was achieved throughout the scaffolds, as shown by micro-computed tomography analysis. ...
Self-Assembled Multienzyme Nanostructures on Synthetic Protein Scaffolds
ACS Nano (IF 13.903) Pub Date : 2019-09-12 ,DOI:10.1021/acsnano.9b04554
Here we present a versatile self-assembly strategy to construct multienzyme nanostructures based on synthetic protein scaffolds. The protein scaffolds were formed using the spontaneous protein reaction of SpyCatcher and SpyTag. ...
Bioinspired Three-Dimensional Magnetoactive Scaffolds for Bone Tissue Engineering
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-21 ,DOI:10.1021/acsami.9b14001
sizes (60, 80, and 120 μm), thus generating 3D scaffolds with different pore sizes. ...
Custom-Size, Functional, and Durable DNA Origami with Design-Specific Scaffolds
ACS Nano (IF 13.903) Pub Date : 2019-04-22 ,DOI:10.1021/acsnano.9b01025
Furthermore, as examples for functionalized scaffolds, we created a scaffold that enables direct, covalent cross-linking of DNA origami via UV irradiation, and we built DNAzyme-containing scaffolds that allow postfolding DNA origami domain separation. ...
Engineering Porous β-Tricalcium Phosphate (β-TCP) Scaffolds with Multiple Channels to Promote Cell Migration, Proliferation, and Angiogenesis
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-25 ,DOI:10.1021/acsami.8b22041
In vitro fluid transportation and degradation of the scaffolds were performed. Cell infiltration, migration, and proliferation of human umbilical vein endothelial cells (HUVECs) on the scaffolds were carried out under both static and dynamic culture conditions. ...
Porous Biomimetic Hyaluronic Acid and Extracellular Matrix Protein Nanofiber Scaffolds for Accelerated Cutaneous Tissue Repair
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-22 ,DOI:10.1021/acsami.9b17322
Tuning these scaffolds’ properties enabled the identification of porosity (∼95%) as a key facilitator for rapid and in-depth cellular ingress in vitro. ...
Modulating smooth muscle cell response by the release of TGFβ2 from tubular scaffolds for vascular tissue engineering
Journal of Controlled Release (IF 7.901) Pub Date : 2019-02-20 ,DOI:10.1016/j.jconrel.2019.02.024
In this study, tubular electrospun scaffolds loaded with TGFβ2 were fabricated using various ratios of gelatin/polycaprolactone (PCL), resulting in scaffolds with porous nano-woven architecture suitable for tissue ingrowth. ...
Three-Dimensional Printing of Biodegradable Piperazine-Based Polyurethane-Urea Scaffolds with Enhanced Osteogenesis for Bone Regeneration
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-13 ,DOI:10.1021/acsami.8b20323
By regulating the contents of PP in P-PUU scaffolds, their mechanical properties could be moderated, and P-PUU1.4 scaffolds with the highest PP contents exhibited the highest compressive modulus (155.9 ± 5.7 MPa) and strength (14.8 ± 1.1 MPa). ...
Cryoprotectant enables structural control of porous scaffolds for exploration of cellular mechano-responsiveness in 3D
Nature Communications (IF 11.878) Pub Date : 2019-08-02 ,DOI:10.1038/s41467-019-11397-1
Finally, in vivo stimulation of endogenous fibroblasts and macrophages by implanted scaffolds produce mechano-responses similar to the corresponding cells in vitro, indicating that the physical properties of scaffolds can be leveraged to modulate tissue regeneration. ...
Enhanced In Vivo Delivery of Stem Cells using Microporous Annealed Particle Scaffolds
Small (IF 10.856) Pub Date : 2019-08-13 ,DOI:10.1002/smll.201903147
Injectable, in situ cross‐linking microporous scaffolds are recently developed that demonstrate a remarkable ability to provide a matrix for cellular proliferation and growth in vitro in three dimensions. The ability of these scaffolds to deliver cells in vivo is currently unknown. ...
Three-Dimensional Printed Polylactic Acid Scaffolds Promote Bone-like Matrix Deposition in Vitro
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-22 ,DOI:10.1021/acsami.9b02502
The scaffolds were compared for cell growth, activity, and bone-like tissue formation using primary human osteoblasts. Osteoblasts showed high proliferation, metabolic activity, and osteogenic matrix protein production, in which 750 μm pore-size scaffolds showed superiority. ...
Template-Free Nanostructured Fluorine-Doped Tin Oxide Scaffolds for Photoelectrochemical Water Splitting
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-30 ,DOI:10.1021/acsami.9b05176
The synthesis and characterization of highly stable and conductive F:SnO2 (FTO) nanopyramid arrays are investigated, and their use as scaffolds for water splitting is demonstrated. ...
Functionalization of Silk Fibroin Electrospun Scaffolds via BMSC Affinity Peptide Grafting through Oxidative Self-Polymerization of Dopamine for Bone Regeneration
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-19 ,DOI:10.1021/acsami.8b22123
These functionalized electrospun scaffolds promoted regeneration of bone in the rat calvarial bone defect model. ...
Sulfated polysaccharide-based scaffolds for orthopaedic tissue engineering
Biomaterials (IF 10.273) Pub Date : 2019-05-21 ,DOI:10.1016/j.biomaterials.2019.05.025
Given their native-like biological properties, high growth factor retention capacity and porous nature, sulfated-polysaccharide-based scaffolds hold great promise for a number of tissue engineering applications. ...
Smart, Elastic, and Nanofiber-Based 3D Scaffolds with Self-Deploying Capability for Osteoporotic Bone Regeneration
Nano Letters (IF 12.279) Pub Date : 2019-12-02 ,DOI:10.1021/acs.nanolett.9b04313
The scaffolds constructed from an assembly of 85SiO2–15CaO nanofibers and chitosan (85SiO2–15CaO NF/CS) possessed significantly better mechanical properties when benchmarked against both 75SiO2–25CaO nanofiber- and chitosan-based scaffolds. ...
The host response to poly(lactide-co-glycolide) scaffolds protects mice from diet induced obesity and glucose intolerance
Biomaterials (IF 10.273) Pub Date : 2019-06-19 ,DOI:10.1016/j.biomaterials.2019.119281
Currently, no treatments specifically target the adipose tissue and we are investigating polymer scaffoldsfor localized drug delivery as a therapeutic platform. In this work we implanted porous poly(lactide-co-glycolide) scaffolds into the epididymal fat of mice. ...
Transfection of autologous host cells in vivo using gene activated scaffolds incorporating star-polypeptides
Journal of Controlled Release (IF 7.901) Pub Date : 2019-05-08 ,DOI:10.1016/j.jconrel.2019.05.009
However, the field still lacks a biocompatible gene delivery vector which is capable of functionalizing scaffolds for tailored nucleic acid delivery. ...
Three-Dimensional Printed Scaffolds with Controlled Micro-/Nanoporous Surface Topography Direct Chondrogenic and Osteogenic Differentiation of Mesenchymal Stem Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-17 ,DOI:10.1021/acsami.9b01472
Only the roughened strut surface has been introduced to 3D printed porous scaffolds. ...
Porous bio-click microgel scaffolds control hMSC interactions and promote their secretory properties
Biomaterials (IF 10.273) Pub Date : 2019-12-27 ,DOI:10.1016/j.biomaterials.2019.119725
However, the role that biomaterial scaffolds can play in controlling hMSC secretory properties has been less explored. ...
Two-Dimensional Black Phosphorus and Graphene Oxide Nanosheets Synergistically Enhance Cell Proliferation and Osteogenesis on 3D Printed Scaffolds
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-14 ,DOI:10.1021/acsami.9b04121
Furthermore, the biomineralization of 3D scaffolds, as well as cellular osteogenic markers, was all measured and improved on scaffolds with both BP and GO nanosheets. ...
Topotactic Fibrillogenesis of Freeze-Cast Microridged Collagen Scaffolds for 3D Cell Culture
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-12 ,DOI:10.1021/acsami.9b03219
These collagen-only, non-cross-linked scaffolds exhibit uncommon mechanical properties in the wet state, with a Young’s modulus of 33 ± 12 kPa, an ultimate tensile stress of 33 ± 6 kPa, and a strain at failure of 105 ± 28%. ...
Vitamin C Loaded Poly(urethane-urea)/ZnAl-LDH Aligned Scaffolds Increase Proliferation of Corneal Keratocytes and Up-Regulate Vimentin Secretion
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-18 ,DOI:10.1021/acsami.9b07556
Viability and proliferation of stromal keratocyte cells on the scaffolds were investigated via AlamarBlue assay. After 24 h, the cells showed similar viability on the scaffolds and the control. ...
Subcutaneously engineered autologous extracellular matrix scaffolds with aligned microchannels for enhanced tendon regeneration
Biomaterials (IF 10.273) Pub Date : 2019-09-12 ,DOI:10.1016/j.biomaterials.2019.119488
The aECM scaffolds promoted rapid cell infiltration, favorable macrophage responses, collagen-rich extracellular matrix (ECM) synthesis, and physiological tissue remodeling in rat Achilles tendon defects. ...
Ex vivo culture of adult CD34+ stem cells using functional highly porous polymer scaffolds to establish biomimicry of the bone marrow niche
Biomaterials (IF 10.273) Pub Date : 2019-10-04 ,DOI:10.1016/j.biomaterials.2019.119533
Emulsion-templated highly porous polyHIPE foam scaffolds were chosen to mimic the honeycomb architecture of human bone. ...
Mussel-Inspired Electroactive and Antioxidative Scaffolds with Incorporation of Polydopamine-Reduced Graphene Oxide for Enhancing Skin Wound Healing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-14 ,DOI:10.1021/acsami.8b18931
Moreover, pGO in the scaffolds serves as an antioxidant agent to scavenge reactive oxygen species (ROS) and therefore terminates excessive ROS oxidation. In vitro studies show that electroactive pGO-CS/SF scaffolds can respond to electrical signals and promote cytological behavior. ...
Hierarchical microchanneled scaffolds modulate multiple tissue-regenerative processes of immune-responses, angiogenesis, and stem cell homing
Biomaterials (IF 10.273) Pub Date : 2019-10-17 ,DOI:10.1016/j.biomaterials.2019.119548
Herein, we report hierarchically structured (‘microchanneled’) 3D printed scaffolds (named ‘μCh’), in contrast to conventional 3D printed scaffolds, induce such cellular responses in a unique way that contributes to accelerated tissue repair and remodeling. ...
Patient-derived scaffolds uncover breast cancer promoting properties of the microenvironment
Biomaterials (IF 10.273) Pub Date : 2019-12-23 ,DOI:10.1016/j.biomaterials.2019.119705
Patient-derived scaffolds thus mimics in vivo-like growth conditions and uncovers unique information about the malignancy-inducing properties of tumor microenvironment. ...
Different functional bio-scaffolds share similar neurological mechanism to promote locomotor recovery of canines with complete spinal cord injury
Biomaterials (IF 10.273) Pub Date : 2019-05-29 ,DOI:10.1016/j.biomaterials.2019.119230
In addition, the spontaneous locomotor recovery of canines could be further promoted by chronic implantation of Taxol- or human bone marrow mesenchymal stem cell-modified bio-scaffolds. ...
Piezoelectric 3-D Fibrous Poly(3-hydroxybutyrate)-Based Scaffolds Ultrasound-Mineralized with Calcium Carbonate for Bone Tissue Engineering: Inorganic Phase Formation, Osteoblast Cell Adhesion, and Proliferation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-17 ,DOI:10.1021/acsami.9b04936
The modification of the wettability for PHB and PHBV scaffolds from hydrophobic (nonmineralized fibers) to superhydrophilic (mineralized fibers) led to a pronounced apatite-forming behavior of scaffolds in a simulated body fluid. ...
Coating of Pt-Loaded Mesoporous Silica Layers on Ceramics Scaffolds for Practical Preservation System for Greengrocery
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-20 ,DOI:10.1021/acsami.9b07011
As a result, Pt@meso-SiO2 with scaffolds (CM and GF) are expected to be effective in commercial application for a practical system of preservation. ...
Improved Multicellular Response, Biomimetic Mineralization, Angiogenesis, and Reduced Foreign Body Response of Modified Polydioxanone Scaffolds for Skeletal Tissue Regeneration
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-30 ,DOI:10.1021/acsami.8b19929
The potential of electrospun polydioxanone (PDX) mats as scaffolds for skeletal tissue regeneration was significantly enhanced through improvement of the cell-mediated biomimetic mineralization and multicellular response. ...
Intra-articular delivery of synovium-resident mesenchymal stem cells via BMP-7-loaded fibrous PLGA scaffolds for cartilage repair
Journal of Controlled Release (IF 7.901) Pub Date : 2019-04-04 ,DOI:10.1016/j.jconrel.2019.04.002
For delivery of synMSCs, fibrous PLGA scaffolds were specifically designed for full-thickness osteochondral defects in rabbits. The scaffolds provided effective micro-environment for growth and host-integration of synMSCs. ...
Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds
Biomaterials (IF 10.273) Pub Date : 2019-10-19 ,DOI:10.1016/j.biomaterials.2019.119551
Here, we investigated the effect of restructuring single iPSC-CMs in specially designed 3D-micro-scaffolds on cell morphology and Ca2+ handling. Using direct laser writing, rectangular-shaped scaffoldswere produced and single iPSC-CMs were seeded into these forms. ...
Bio-orthogonal click reaction-enabled highly specific in situ cellularization of tissue engineering scaffolds
Biomaterials (IF 10.273) Pub Date : 2019-11-11 ,DOI:10.1016/j.biomaterials.2019.119615
Tissue engineering generally utilizes natural or synthetic scaffolds to repair or replace damaged tissues. However, due to the lack of guidance of biological signals, most of the implanted scaffolds have always suffered from poor in vivo cellularization. ...
Modulation of Cellular Colonization of Porous Polyurethane Scaffolds via the Control of Pore Interconnection Size and Nanoscale Surface Modifications
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-24 ,DOI:10.1021/acsami.9b04625
We, therefore, claim that both pore interconnection size and surface treatment play a significant role to improve the quality of integration of tissue engineering scaffolds. ...
Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds.
Nature Communications (IF 11.878) Pub Date : 2019-Jan-0 ,DOI:10.1038/s41467-018-07938-9
Here, we demonstrate that an evolutionarily conserved fragment located in the C-terminal cytoplasmic tail of BAI-aGPCRs is specifically recognized by the RBD-ARR-ELMO (RAE) supramodule of the ELMO family scaffolds. ...
Microporous polysaccharide multilayer coated BCP composite scaffolds with immobilised calcitriol promote osteoporotic bone regeneration both in vitro and in vivo
Theranostics (IF 8.063) Pub Date : 2019-01-30 ,DOI:10.7150/thno.29566
The PEM-coated scaffolds showed advantages in Cal loading and retention, especially at lower drug concentrations. ...
Nanoparticle-Based Hybrid Scaffolds for Deciphering the Role of Multimodal Cues in Cardiac Tissue Engineering
ACS Nano (IF 13.903) Pub Date : 2019-10-28 ,DOI:10.1021/acsnano.9b03050
Here, we employed gelatin methacryloyl (GelMA) hydrogels containing three different types of carbon-based nanoparticles: carbon nanotubes (CNTs), graphene oxide (GO), and reduced GO (rGO), to investigate the influence of these hybrid scaffolds on the structural organization and functionality of cardiomyocytes ...
Collagen scaffolds functionalised with copper-eluting bioactive glass reduce infection and enhance osteogenesis and angiogenesis both in vitro and in vivo
Biomaterials (IF 10.273) Pub Date : 2019-01-23 ,DOI:10.1016/j.biomaterials.2019.01.031
Scaffolds demonstrated antibacterial activity against Staphylococcus aureus (up to 66% inhibition) whilst also enhancing osteogenesis (up to 3.6-fold increase in calcium deposition) and angiogenesis in vitro. ...
Tropoelastin-Coated Tendon Biomimetic Scaffolds Promote Stem Cell Tenogenic Commitment and Deposition of Elastin-Rich Matrix
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-24 ,DOI:10.1021/acsami.9b04616
We found that human adipose-derived stem cells (hASCs) seeded onto these TROPO biomimetic scaffolds more rapidly acquired their spindle-shape morphology and high aspect ratio characteristic of tenocytes. ...
Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9
Nature Communications (IF 11.878) Pub Date : 2019-03-04 ,DOI:10.1038/s41467-019-08868-w
We correlate these structures to their ability to activate TLR9 and show that a key criterion is the AMP’s ability to assemble into superhelical protofibril scaffolds. ...
Polyproline Tri‐Helix Macrocycles as Nanosized Scaffolds to Control Ligand Patterns for Selective Protein Oligomer Interactions
Small (IF 10.856) Pub Date : 2019-04-12 ,DOI:10.1002/smll.201900561
The lack of adjustable universal tools to control ligand positions at the size of a few nanometers has prompted the development of polyproline tri‐helix macrocycles as scaffolds to present ligands in designated patterns. ...
Liquid-Crystalline Hydroxyapatite/Polymer Nanorod Hybrids: Potential Bioplatform for Photodynamic Therapy and Cellular Scaffolds
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-01 ,DOI:10.1021/acsami.9b02485
The cells cultured on the oriented scaffolds showed cellular alignment and elongation along the oriented direction of the hybrid nanorods. The HAp/PAA hybrid nanorods demonstrate potential in drug delivery and tissue engineering. ...
Fabrication of 3D scaffolds reproducing intestinal epithelium topography by high-resolution 3D stereolithography
Biomaterials (IF 10.273) Pub Date : 2019-08-05 ,DOI:10.1016/j.biomaterials.2019.119404
This approach offers the possibility to create artificial 3D scaffolds matching the dimensions and architecture of mouse intestinal crypts and villi. We demonstrate that these 3D culture models support the growth and differentiation of Caco-2 cells for 3 weeks. ...
Triple PLGA/PCL Scaffold Modification Including Silver Impregnation, Collagen Coating, and Electrospinning Significantly Improve Biocompatibility, Antimicrobial, and Osteogenic Properties for Orofacial Tissue Regeneration
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-07 ,DOI:10.1021/acsami.9b07053
There was a wider antibacterial zone associated in PP-pDA-Ag-COL and PP-pDA-Ag scaffolds versus control scaffolds (P < 0.05), and bacterial fluorescence was reduced on the Ag-modified scaffolds after 24 h inoculation against Staphylococcus aureus and Streptococcus mutans. ...
Hydroxyapatite mineral enhances malignant potential in a tissue-engineered model of ductal carcinoma in situ (DCIS)
Biomaterials (IF 10.273) Pub Date : 2019-09-11 ,DOI:10.1016/j.biomaterials.2019.119489
Moreover, MCF10DCIS.com xenografts in HA scaffolds displayed evidence of enhanced malignant progression relative to xenografts in control scaffolds. ...
Universal Biofactor-Releasing Scaffold Enabling in Vivo Reloading
Nano Letters (IF 12.279) Pub Date : 2019-03-05 ,DOI:10.1021/acs.nanolett.8b04927
The scaffolds can be reloaded in vitro or in vivo with any His-tagged biomolecule at any time according to the physiological need. We show the ability of the scaffolds to release angiogenic factors in a static cell culture or under flow in a microfluidics device and effect on endothelial cells. ...
Biomimetic Carbon Fiber Systems Engineering: A Modular Design Strategy To Generate Biofunctional Composites from Graphene and Carbon Nanofibers
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-25 ,DOI:10.1021/acsami.8b17627
The resulting 3D carbon scaffolds are both hierarchically ordered and free-standing. ...
3D Bioprinted Scaffolds Containing Viable Macrophages and Antibiotics Promote Clearance of Staphylococcus aureus Craniotomy-Associated Biofilm Infection
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-21 ,DOI:10.1021/acsami.9b00264
We also examined a prevention paradigm, where the scaffolds were placed at the time of surgery and challenged with S. aureus one day later at the surgical site. ...
Liposome-Encapsulated Curcumin-Loaded 3D Printed Scaffold for Bone Tissue Engineering
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-01 ,DOI:10.1021/acsami.9b01218
In this study, we have increased the bioavailability of curcumin by encapsulating it in a liposome, followed by the incorporation onto 3D printed (3DP) calcium phosphate (CaP) scaffolds with designed porosity. 3DP scaffolds with a designed shape and interconnected porosity allow for the fabrication of ...
Visualizing in Vivo Dynamics of Designer Nanoscaffolds
Nano Letters (IF 12.279) Pub Date : 2019-12-03 ,DOI:10.1021/acs.nanolett.9b03651
Real-time observation of this system reveals a nucleation-limited step where multiple scaffolds initially form within a cell. Over time, nucleated scaffolds reorganize into a single intracellular assembly, likely due to interscaffold competition for protein subunits. ...
On Low-Concentration Inks Formulated by Nanocellulose Assisted with Gelatin Methacrylate (GelMA) for 3D Printing toward Wound Healing Application
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-20 ,DOI:10.1021/acsami.8b21268
The mechanical strength of the scaffolds was tuned in the range of 2.5 to 5 kPa. The cell culture with 3T3 fibroblasts revealed noncytotoxic and biocompatible features for the formulated inks and printed scaffolds. ...
Copper-incorporated bioactive glass-ceramics inducing anti-inflammatory phenotype and regeneration of cartilage/bone interface
Theranostics (IF 8.063) Pub Date : 2019-08-14 ,DOI:10.7150/thno.36120
We hypothesized that the Cu2+ released from Cu-BGC scaffolds may satisfy the requirements of cartilage regeneration and anti-arthritis. Methods: 3D-printing method was employed to prepare Cu-BGC scaffolds. ...
Free radical-decellularized tissue promotes enhanced antioxidant and anti-inflammatory macrophage response
Biomaterials (IF 10.273) Pub Date : 2019-07-25 ,DOI:10.1016/j.biomaterials.2019.119376
Extracellular matrix scaffolds have been used successfully in reconstructive applications due to the beneficial host response they induce. To tailor extracellular matrix scaffolds to enhance antioxidant response, ECM were prepared using reactive nitrogen or oxygen species. ...
3D porous chitosan-alginate scaffold stiffness promotes differential responses in prostate cancer cell lines
Biomaterials (IF 10.273) Pub Date : 2019-06-28 ,DOI:10.1016/j.biomaterials.2019.119311
The CA scaffolds are a 3D culture platform that supports PCa growth and phenotypic expression with adjustable scaffold stiffness to mimic stages of metastatic progression. ...
Functionalization of SF/HAP Scaffold with GO-PEI-miRNA inhibitor Complexes to Enhance Bone Regeneration through Activating Transcription Factor 4
Theranostics (IF 8.063) Pub Date : 2019-06-09 ,DOI:10.7150/thno.34676
Results: SF/HAP/GO scaffolds with nanosized GO show high mechanical strength, and their hierarchical microporous structures promote cell adhesion and growth. ...
Developing a Strontium-Releasing Graphene Oxide-/Collagen-Based Organic–Inorganic Nanobiocomposite for Large Bone Defect Regeneration via MAPK Signaling Pathway
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-16 ,DOI:10.1021/acsami.8b22606
The prepared Sr–GO–Col scaffold demonstrates significantly high water retention rates and excellent mechanical properties compared with unmodified Col scaffolds. ...
Epac agonist improves barrier function in iPSC-derived endothelial colony forming cells for whole organ tissue engineering
Biomaterials (IF 10.273) Pub Date : 2019-02-07 ,DOI:10.1016/j.biomaterials.2019.02.005
In this study, we investigated whether various small molecules could favorably impact endothelial functionality after seeding into decellularized lung scaffolds. We demonstrated that the Epac-selective cAMP analog 8CPT-2Me-cAMP improves endothelial barrier function in repopulated lung scaffolds. ...
Artificial Photosynthesis with Electron Acceptor/Photosensitizer-Aptamer Conjugates
Nano Letters (IF 12.279) Pub Date : 2019-08-15 ,DOI:10.1021/acs.nanolett.9b02880
Sequence-specific aptamers act as functional scaffolds for the assembly of photosynthetic model systems. The Ru(II)-tris-bipyridine photosensitizer is conjugated by different binding modes to the antityrosinamide aptamer to yield a set of photosensitizer-aptamer binding scaffolds. ...
Correction to “Janus Nanocomposite Hydrogels for Chirality-Dependent Cell Adhesion and Migration”
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-14 ,DOI:10.1021/acsami.9b09747
Experimental procedures of the synthesis, functionalization of PMOs and zeolites L; analytic characterization data (SEM, IR) and physicochemical properties of functionalized PMOs and zeolites L; analytic characterization data of alginate and NC hydrogel scaffolds; SEM images of NC hydrogel scaffolds; ...
Mussel-Inspired Nanostructures Potentiate the Immunomodulatory Properties and Angiogenesis of Mesenchymal Stem Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-06 ,DOI:10.1021/acsami.8b22017
We found that Ad-MSCs cultured on polydopamine-modified BC scaffolds (DOPA-BC) significantly produced more immunomodulatory and pro-angiogenic factors when compared with those cultured on BC scaffolds or microplates. ...
Conductive Biomaterials for Muscle Tissue Engineering
Biomaterials (IF 10.273) Pub Date : 2019-10-31 ,DOI:10.1016/j.biomaterials.2019.119584
Conductive biomaterials are good candidates as scaffolds in muscle tissue engineering due to their proper conductivity and their promotion on muscle tissue formation. ...
Highly Versatile Cell-Penetrating Peptide Loaded Scaffold For Efficient and Localized Gene Delivery To Multiple Cell Types: From Development to Application in Tissue Engineering
Biomaterials (IF 10.273) Pub Date : 2019-06-13 ,DOI:10.1016/j.biomaterials.2019.119277
Finally, GET carrying osteogenic (pBMP-2) and angiogenic (pVEGF) genes were incorporated into collagen-hydroxyapatite scaffolds and with a single 2μg dose of therapeutic pDNA, induced complete repair of critical-sized bone defects within 4 weeks. ...
Nonviolent Self-Catabolic DNAzyme Nanosponges for Smart Anticancer Drug Delivery
ACS Nano (IF 13.903) Pub Date : 2019-05-06 ,DOI:10.1021/acsnano.9b01589
The supplement Zn2+ cofactors mediated the nonviolent DNAzyme-catalyzed cleavage of DNA scaffoldsfor precise and efficient drug administrations with synergistically enhanced therapeutic performance. ...
Scaffold-facilitated locomotor improvement post complete spinal cord injury: motor axon regeneration versus endogenous neuronal relay formation
Biomaterials (IF 10.273) Pub Date : 2019-01-07 ,DOI:10.1016/j.biomaterials.2019.01.012
Last, the current approach of directing endogenous neuronal relays formation to achieve motor function recovery by well-designed functional bio-scaffolds implantation in complete transected SCI animals is reviewed. ...
Functional Graphenic Materials That Seal Condenser Tube Leaks in Situ
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-04 ,DOI:10.1021/acsami.9b05313
Further, FGM sealants were adhesive, effectively sealing defects in a model experiment, whereas unfunctionalized scaffolds did not display any sealant capacity. ...
Anatomical meniscus construct with zone specific biochemical composition and structural organization
Biomaterials (IF 10.273) Pub Date : 2019-07-15 ,DOI:10.1016/j.biomaterials.2019.119361
Gene expression of the cells in agarose (Ag), gelatin methacrylate (GelMA), and GelMA-Ag hydrogels was significantly higher than that of cells on the PCL scaffolds after a 21-day culture. ...
Oriented collagen fiber membranes formed through counter-rotating extrusion and their application in tendon regeneration
Biomaterials (IF 10.273) Pub Date : 2019-03-29 ,DOI:10.1016/j.biomaterials.2019.03.041
Well-aligned collagen fiber scaffolds are considered promising candidates for tendon tissue engineering in terms of their biomimetic chemical composition and topographic structure. ...
Reconstruction of the ovary microenvironment utilizing macroporous scaffold with affinity-bound growth factors
Biomaterials (IF 10.273) Pub Date : 2019-03-14 ,DOI:10.1016/j.biomaterials.2019.03.013
Porcine primordial follicles developed in the alginate scaffolds up to the pre-antral stage within 21 days. ...
Contact Guidance by Microstructured Gelatin Hydrogels for Prospective Tissue Engineering Applications
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-05 ,DOI:10.1021/acsami.8b21638
Design of functionalized biomimetic scaffolds is one of the key approaches for regenerative medicine and other biomedical applications. Development of engineered tissue should optimize organization and function of cells and tissue in vitro as well as in vivo. ...
Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection
Nature Communications (IF 11.878) Pub Date : 2019-10-23 ,DOI:10.1038/s41467-019-12835-w
As a result of their finely tuned properties, these scaffolds demonstrate the ability to promote and guide neurite extension ex vivo and protect neurons from oxidative stress in vitro. ...
Multiscale Porosity in Compressible Cryogenically 3D Printed Gels for Bone Tissue Engineering
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-24 ,DOI:10.1021/acsami.9b05460
With cryogenic 3D printing, up to 90% microporosity could be incorporated into the scaffolds. ...
Chiral Perovskite: Chiral Perovskites: Promising Materials toward Next‐Generation Optoelectronics (Small 39/2019)
Small (IF 10.856) Pub Date : 2019-09-25 ,DOI:10.1002/smll.201970209
The introduction of chirality into perovskite scaffolds, leading to the generation of chiral perovskites, is an immense step forward toward the development of smart optoelectronic and spintronic materials and devices. ...
Stimuli-Responsive Conductive Nanocomposite Hydrogels with High Stretchability, Self-Healing, Adhesiveness, and 3D Printability for Human Motion Sensing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-07 ,DOI:10.1021/acsami.8b20178
Self-healing, adhesive conductive hydrogels are of great significance in wearable electronic devices, flexible printable electronics, and tissue engineering scaffolds. ...
Molecular architecture of a cylindrical self-assembly at human centrosomes
Nature Communications (IF 11.878) Pub Date : 2019-03-11 ,DOI:10.1038/s41467-019-08838-2
Because pericentriolar material organization is evolutionarily conserved, this work may offer a paradigm for investigating the assembly and function of centrosomal scaffolds in various organisms. ...
Construction of Tetrahedral DNA-Quantum Dot Nanostructure with the Integration of Multistep Förster Resonance Energy Transfer for Multiplex Enzymes Assay
ACS Nano (IF 13.903) Pub Date : 2019-06-12 ,DOI:10.1021/acsnano.9b02679
Three-dimensional (3D) DNA scaffolds with well-defined structure and high controllability hold promising potentials for biosensing and drug delivery. However, most of 3D DNA scaffolds can detect only a single type of molecule with the involvement of complex logic operations. ...
Three-dimensionally Patterned Scaffolds Modulate the Biointerface at the Nanoscale
Nano Letters (IF 12.279) Pub Date : 2019-07-03 ,DOI:10.1021/acs.nanolett.9b01468
The main aim of cell instructive materials is to guide in a controlled way cellular behavior by fine-tuning cell-material crosstalk. In the last decades, several efforts have been spent in elucidating the relations between material cues and cellular fate at the nanoscale and in the development of novel strategies for gaining a superior control over cellular function modulation. In this context, a particular attention has been recently paid to the role played by cellular membrane rearrangement in triggering specific molecular pathways linked to the regulation of different cellular functions. Here, we characterize the effect of linear microtopographies upon cellular behavior in three-dimensional (3D) environments, with particular focus on the relations linking cytoskeleton structuration to membrane rearrangement and internalization tuning. The performed analysis shown that, by altering the cellular adhesion processes at the micro- and nanoscale, it is possible to alter the membrane physical state and cellular internalization capability. More specifically, our findings pointed out that an increased cytoskeletal structuration influences the formation of nanoinvagination membrane process at the cell–material interface and the expression of clathrin and caveolin, two of the main proteins involved in the endocytosis regulation. Moreover, we proved that such topographies enhance the engulfment of inert polystyrene nanoparticles attached on 3D patterned surfaces. Our results could give new guidelines for the design of innovative and more efficient 3D cell culture systems usable for diagnostic, therapeutic, and tissue engineering purposes. ...
Porous Graphene-Carbon Nanotube Scaffolds for Fiber Supercapacitors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-17 ,DOI:10.1021/acsami.8b17908
Fiber nanomaterials can become fundamental devices that can be woven into smart textiles, for example, miniaturized fiber-based supercapacitors (FSCs). They can be utilized for portable, wearable electronics and energy storage devices, which are highly prospective areas of research in the future. Herein, we developed porous carbon nanotube–graphene hybrid fibers (CNT–GFs) for all-solid-state symmetric FSCs, which were assembled through wet-spinning followed by a hydrothermal activation process using environmentally benign chemicals (i.e., H2O2 and NH4OH in deionized water). The barriers that limited effective ion accessibility in GFs were overcome by the intercalation of CNTs in the GFs which enhanced their electrical conductivity and mechanical properties as well. The all-solid-state symmetric FSCs of a precisely controlled activated hybrid fiber (a-CNT–GF) electrode exhibited an enhanced volumetric capacitance of 60.75 F cm–3 compared with those of a pristine CNT–GF electrode (19.80 F cm–3). They also showed a volumetric energy density (4.83 mWh cm–3) roughly 3 times higher than that of untreated CNT–GFs (1.50 mWh cm–3). The excellent mechanical flexibility and structural stability of a miniaturized a-CNT–GF are highlighted by the demonstration of negligible differences in capacitance upon bending and twisting. The mechanism of developing porous, large-scale, low-cost electrodes using an environmentally benign activation method presented in this work provides a promising route for designing a new generation of wearable, portable miniaturized energy storage devices. ...
Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect
Biomaterials (IF 10.273) Pub Date : 2019-01-07 ,DOI:10.1016/j.biomaterials.2019.01.013
In summary, PTM scaffolds are promising composite biomaterials for repairing challenging bone defect that would have great potential for its clinical translation. ...
E-jet 3D printed drug delivery implants to inhibit growth and metastasis of orthotopic breast cancer
Biomaterials (IF 10.273) Pub Date : 2019-11-13 ,DOI:10.1016/j.biomaterials.2019.119618
Poly-lactic-co-glycolic acid scaffolds were fabricated by 3D printing to immobilize 5-fluorouracil and NVP-BEZ235. ...
Nanogels for regenerative medicine
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-16 ,DOI:10.1016/j.jconrel.2019.09.015
Healing of chronic wounds and critical size bone fractures may significantly improve thanks to the use of nanogels solely or in combination with scaffolds. Nanogel roles in regenerating vessels, cardiac tissue, urothelium and urethral muscle tissue are also presented. ...
Engineering a naturally-derived adhesive and conductive cardiopatch
Biomaterials (IF 10.273) Pub Date : 2019-03-21 ,DOI:10.1016/j.biomaterials.2019.03.015
Here, we introduce highly adhesive fibrous scaffolds engineered by electrospinning of gelatin methacryloyl (GelMA) followed by the conjugation of a choline-based bio-ionic liquid (Bio-IL) to develop conductive and adhesive cardiopatches. ...
Impact of Biomimicry in the Design of Osteoinductive Bone Substitutes: Nanoscale Matters
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-21 ,DOI:10.1021/acsami.8b20749
These findings correlated well with the superior bone-healing capacity showed by the fine-CDHA scaffolds when implanted intraosseously. ...
Control of Dissipation Sources: A Central Aspect for Enhancing the Mechanical and Mechanobiological Performances of Hydrogels
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-16 ,DOI:10.1021/acsami.9b15450
While fluid frictional drag is playing a significant role in this phenomenon, the flow-dependent source of dissipation is mostly overlooked in the design of hydrogel scaffolds. ...
Rolling Circle Transcription-Amplified Hierarchically Structured Organic–Inorganic Hybrid RNA Flowers for Enzyme Immobilization
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-19 ,DOI:10.1021/acsami.9b04663
In particular, we showed that hRNFs can serve as soft scaffolds for β-galactosidase immobilization and greatly enhance enzymatic activity and stability. ...
Aggregation‐Induced Electrochemiluminescence by Metal‐Binding Protein Responsive Hydrogel Scaffolds
Small (IF 10.856) Pub Date : 2019-04-05 ,DOI:10.1002/smll.201901170
Functionalized hydrogels have aroused general interest due to their versatile applications in biomaterial fields. This work reports a hydrogel network composed of gold nanoclusters linked with bivalent cations such as Ca2+, Mg2+, and Zn2+. The hydrogel exhibits both aggregation‐induced emission (AIE) and aggregation‐induced electrochemiluminescence (AIECL) effects. Most noteworthy, the AIECL effect (≈50‐fold enhancement) is even more significant than the corresponding AIE effect (approximately fivefold enhancement). Calmodulin, a Ca2+ binding protein, may efficiently regulate the AIECL dynamics after specific binding of the Ca2+ linker, with the linear range from 0.3 to 50 µg mL−1 and a limit of detection of 0.1 µg mL−1. Considering the important roles of bivalent cations in the life system, these results may pave a new avenue for the design of a biomolecule‐responsive AIECL‐type hydrogel with multifunctional biomedical purposes. ...
Gold-Decorated M13 I-Forms and S-Forms for Targeted Photothermal Lysis of Bacteria
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-18 ,DOI:10.1021/acsami.9b15682
With the shape-modified M13 scaffolds, up to 64% of E. coli were killed within 20 min. These studies demonstrate the promise of i-form and s-form polymorphs for the directed plasmonic-based photothermal killing of bacteria. ...
Electroactive composite scaffold with locally expressed osteoinductive factor for synergistic bone repair upon electrical stimulation
Biomaterials (IF 10.273) Pub Date : 2019-11-14 ,DOI:10.1016/j.biomaterials.2019.119617
Unfortunately, the broad application of growth factors is limited by their poor stability in the scaffolds. ...
Macroporous heparin-based microcarriers allow long-term 3D culture and differentiation of neural precursor cells
Biomaterials (IF 10.273) Pub Date : 2019-10-11 ,DOI:10.1016/j.biomaterials.2019.119540
Herein, we culture NPCs on microscale scaffolds termed microcarriers, composed of poly(ethylene glycol) and heparin, designed to more closely represent the 3D environment of the neurogenic niche. ...
Chiral Perovskites: Promising Materials toward Next‐Generation Optoelectronics
Small (IF 10.856) Pub Date : 2019-08-06 ,DOI:10.1002/smll.201902237
The introduction of chirality into perovskite scaffolds, generating a novel concept of chiral perovskite materials, offers an immense step forward toward the development of smart optoelectronic and spintronic materials and devices. ...
Two‐Photon Vertical‐Flow Lithography for Microtube Synthesis
Small (IF 10.856) Pub Date : 2019-06-06 ,DOI:10.1002/smll.201901356
The interplay between fluid‐flow control and two‐photon lithography presents a generic high‐resolution method that will substantially contribute toward the future development of biocompatible scaffolds, stents, needles, nerve guides, membranes, and beyond. ...
Polydopamine-Based Interfacial Engineering of Extracellular Matrix Hydrogels for the Construction and Long-Term Maintenance of Living Three-Dimensional Tissues
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-25 ,DOI:10.1021/acsami.9b07912
We leveraged a single-step surface functionalization technique based on polydopamine to drastically increase the strength of adhesion between hydrogel scaffolds and cell culture substrates. ...
Sustained Release SDF-1α/TGF-β1-Loaded Silk Fibroin-Porous Gelatin Scaffold Promotes Cartilage Repair
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-15 ,DOI:10.1021/acsami.9b01532
Furthermore, MSCs acquired enhanced chondrogenic differentiation capability in the TGF-β1-loaded scaffolds (GSTS or GST: loading TGF-β1 only) and the conditioned medium from SDF-1α-loaded scaffolds(GSTS or GSS: loading SDF-1α only) effectively promoted MSCs migration. ...
Spatially Regulated Multiphenotypic Differentiation of Stem Cells in 3D via Engineered Mechanical Gradient
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-25 ,DOI:10.1021/acsami.9b17266
Human mesenchymal stem cells (hMSCs) were cultured in electrospun scaffolds with a linear or biphasic mechanical gradient, which was computationally engineered and experimentally validated. ...
Influence of Hydrolyzed Polyacrylamide Hydrogel Stiffness on Podocyte Morphology, Phenotype, and Mechanical Properties
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-28 ,DOI:10.1021/acsami.9b09337
In this work, Hydrolyzed PAAm scaffolds having different stiffness ranging between 0.6–44 kPa are prepared. The correlation between the hydrogel structural and mechanical properties and Podocyte morphology, elasticity, cytoskeleton reorganization, and podocin expression is evaluated. ...
Bioinspired Mineralization with Hydroxyapatite and Hierarchical Naturally Aligned Nanofibrillar Cellulose
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-25 ,DOI:10.1021/acsami.9b09443
The ultrastructure and mechanical properties of the mineralized gels were strikingly similar to those of bone and dentin, which supports further use of cellulose-based fibrillary materials as affordable, biocompatible scaffolds for repair and regeneration of hard tissues. ...
Bimetallic PdCu Nanocrystals Immobilized by Nitrogen-Containing Ordered Mesoporous Carbon for Electrocatalytic Denitrification
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-15 ,DOI:10.1021/acsami.8b17880
Issues of uniform incorporation of catalytic functional species with controllable sizes, shapes, compositions, and functions into porous carbon scaffolds remain significant challenges toward enriching and boosting performance. ...
Development of a lipoplex-type mRNA carrier composed of an ionizable lipid with a vitamin E scaffold and the KALA peptide for use as an ex vivo dendritic cell-based cancer vaccine
Journal of Controlled Release (IF 7.901) Pub Date : 2019-08-03 ,DOI:10.1016/j.jconrel.2019.08.002
We previously reported on an ionizable lipid-like material with vitamin E-scaffolds (ssPalmE) as a material for a lipid nanoparticle (LNP)-based carrier for nucleic acids. ...
A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings
Nature Communications (IF 11.878) Pub Date : 2019-09-05 ,DOI:10.1038/s41467-019-11976-2
The interrogation of complex biological pathways demands diverse small molecule tool compounds, which can often lead to important therapeutics for the treatment of human diseases. Since natural products are the most valuable source for the discovery of therapeutics, the derivatization of natural products has been extensively investigated to generate molecules for biological screenings. However, most previous approaches only modified a limited number of functional groups, which resulted in a limited number of skeleta. Here we show a general strategy for the preparation of a library of complex small molecules by combining state-of-the-art chemistry – the site-selective oxidation of C-H bonds - with reactions that expand rigid, small rings in polycyclic steroids to medium-sized rings. This library occupies a unique chemical space compared to selected diverse reference compounds. The diversification strategy developed herein for steroids can also be expanded to other types of natural products. ...
Building Carbon‐Based Versatile Scaffolds on the Electrode Surface to Boost Capacitive Performance for Fiber Pseudocapacitors
Small (IF 10.856) Pub Date : 2019-04-17 ,DOI:10.1002/smll.201900721
In order to fabricate high performance fiber pseudocapacitors, the trade‐off between high mass loading and high utilization efficiency of pseudocapacitive materials should be carefully addressed. Here, a solution that is to construct a carbon‐based versatile scaffold is reported for loading pseudocapacitive materials on carbonaceous fibers. The scaffold can be easily built by conformally coating commercial pen ink on the fibers without any destruction to the fiber skeleton. Due to the high electrical conductivity and abundant macropore structure, it can provide sufficient loading room and a high ion/electron conductive network for pseudocapacitive materials. Therefore, their loading mass and utilization efficiency can be increased simultaneously, and thus the as‐designed fibrous electrode displays a high areal capacitance of 649 mF cm−2 (or 122 mF cm−1 based on length), which is higher than most of the reported fiber pseudocapacitors. The simple and low‐cost strategy opens up a new way to prepare high performance portable/wearable energy storage devices. ...
Fluorescence Enhancement from Nitro-Compound-Sensitive Bacteria within Spherical Hydrogel Scaffolds
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-05 ,DOI:10.1021/acsami.9b02262
For the safety of both production and life, it is a very significant issue to detect explosive nitro compounds in a remote way or over a long distance. Here, we report that nitro compounds were detected by the bacterial sensor based on hydrogel microbeads as a platform. Green fluorescent protein-producing Escherichia coli, which was genetically engineered to be sensitive to nitro compounds, was loaded within poly(2-hydroxyethyl methacrylate) [poly(HEMA)]-based hydrogel beads, in which fluorescent signals from bacteria were concentrated and strong enough to be easily detected. For efficient loading of negatively charged bacteria, the surface charge of poly(HEMA)-based beads was controlled by copolymerization with 2-(methacryloyloxy)ethyltrimethylammonium chloride (MAETC) as a cationic monomer. With the addition of MAETC, the cell affinity was nine times enhanced by the interaction between the positively charged poly(HEMA-co-MAETC) beads and negatively charged bacteria. The increased cell affinity resulted in an enhancement of a sensing signal. After exposure to 2,4,6-trinitrotoluene, a typical explosive nitro compound, the fluorescence intensity of bacterial sensors using poly(HEMA-co-MAETC) beads having 80 wt % MAETC was five times increased compared to those based on poly(HEMA) beads. This amplification of the fluorescent signal enables easier detection of explosives efficiently by a remote detection, even over a long distance. ...
Electrochemical oxidation induced intermolecular aromatic C-H imidation
Nature Communications (IF 11.878) Pub Date : 2019-11-29 ,DOI:10.1038/s41467-019-13524-4
A wide variety of arenes, heteroarenes, alkenes and sulfonimides are applicable scaffolds in this transformation. In addition, aryl sulfonamides or amines (aniline derivatives) can be obtained through different deprotection process. ...
Biomimetic open porous structured core-shell microtissue with enhanced mechanical properties for bottom-up bone tissue engineering.
Theranostics (IF 8.063) Pub Date : 2019-08-02 ,DOI:10.7150/thno.34464
Rat bone marrow mesenchymal stem cells (BMSCs) were seeded on the micro-scaffolds, after which they were dynamic cultured and osteo-induced in mini-capsule bioreactors to fabricate microtissues. ...
Organocatalytic atroposelective construction of axially chiral arylquinones
Nature Communications (IF 11.878) Pub Date : 2019-09-19 ,DOI:10.1038/s41467-019-12269-4
With o-naphthoquinone as both the electrophile and the oxidant, three types of arylation counterparts, namely 2-naphthylamines, 2-naphthols and indoles, are utilized to assemble a series of atropisomeric scaffolds in good yields and excellent enantioselectivities. ...
Rhodium-catalysed direct hydroarylation of alkenes and alkynes with phosphines through phosphorous-assisted C−H activation
Nature Communications (IF 11.878) Pub Date : 2019-08-06 ,DOI:10.1038/s41467-019-11420-5
Based on the outstanding properties of the parent scaffolds, a general method for in situ modification of the commercial tertiary phosphine ligands to access a series of ligands is in high demand. ...
Well-Ordered Inorganic Nanoparticle Arrays Directed by Block Copolymer Nanosheets
ACS Nano (IF 13.903) Pub Date : 2019-05-30 ,DOI:10.1021/acsnano.9b00940
Here, we report the directed arrangement of inorganic nanoparticles into arrayed structures with long-range order, up to tens of microns, by using hexagonally-packed cylindrical patterns of block copolymer nanosheets self-assembled within collapsed emulsion droplets as scaffolds. ...
Self-Nanoemulsifying Electrospun Fiber Enhancing Drug Permeation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-18 ,DOI:10.1021/acsami.8b21967
Electrospun fibers are excellent drug carriers and tissue engineering scaffolds. However, approaches to promote drug permeation in tissues with such carriers remain of great interest. ...
Bioinspired Struvite Mineralization for Fire-Resistant Wood
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-24 ,DOI:10.1021/acsami.8b19967
A crucial flaw of the renewable wood scaffolds is the low flame retardancy, which we tackled by bioinspired mineralization in an eco-friendly processing step. ...
GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation.
Nature Communications (IF 11.878) Pub Date : 2019-Jan-1 ,DOI:10.1038/s41467-018-08044-6
COPI is a key mediator of protein trafficking within the secretory pathway. COPI is recruited to the membrane primarily through binding to Arf GTPases, upon which it undergoes assembly to form coated transport intermediates responsible for trafficking numerous proteins, including Golgi-resident enzymes. Here, we identify GORAB, the protein mutated in the skin and bone disorder gerodermia osteodysplastica, as a component of the COPI machinery. GORAB forms stable domains at the trans-Golgi that, via interactions with the COPI-binding protein Scyl1, promote COPI recruitment to these domains. Pathogenic GORAB mutations perturb Scyl1 binding or GORAB assembly into domains, indicating the importance of these interactions. Loss of GORAB causes impairment of COPI-mediated retrieval of trans-Golgi enzymes, resulting in a deficit in glycosylation of secretory cargo proteins. Our results therefore identify GORAB as a COPI scaffolding factor, and support the view that defective protein glycosylation is a major disease mechanism in gerodermia osteodysplastica. ...
Self‐Assembled Collagen Microparticles by Aerosol as a Versatile Platform for Injectable Anisotropic Materials
Small (IF 10.856) Pub Date : 2019-12-27 ,DOI:10.1002/smll.201902224
The efficiency of this approach for making easily handleable collagen microparticles for encapsulation and injection opens perspectives in active tissue regeneration and 3D bioprinted scaffolds. ...
Hierarchical Porous Wood Cellulose Scaffold with Atomically Dispersed Pt Catalysts for Low-Temperature Ethylene Decomposition
ACS Nano (IF 13.903) Pub Date : 2019-12-05 ,DOI:10.1021/acsnano.9b07801
Using a cellulose structure derived from wood, we fabricate hierarchical porous cellulose scaffoldscombining with cerium-doped TiO2. This hybrid material serves as the support for atomically dispersed Pt catalysts and is used to successfully decompose ethylene at 0 °C. ...
Direct spinning and densification method for high-performance carbon nanotube fibers
Nature Communications (IF 11.878) Pub Date : 2019-07-04 ,DOI:10.1038/s41467-019-10998-0
Developing methods to assemble nanomaterials into macroscopic scaffolds is of critical significance at the current stage of nanotechnology. ...
Removal of a Conserved Disulfide Bond Does Not Compromise Mechanical Stability of a VHH Antibody Complex
Nano Letters (IF 12.279) Pub Date : 2019-07-05 ,DOI:10.1021/acs.nanolett.9b02062
These results demonstrate that mechanostable binding interactions can be built on molecular scaffoldsthat may be thermodynamically compromised at equilibrium. ...
Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis
Nature Communications (IF 11.878) Pub Date : 2019-06-27 ,DOI:10.1038/s41467-019-10687-y
Screening a library of benzoxaboroles comprised of analogs to four antiprotozoal chemical scaffoldsunder pre-clinical development for neglected tropical diseases for Cryptosporidium growth inhibitors identifies the 6-carboxamide benzoxaborole AN7973. ...
Sensor-Instrumented Scaffold Integrated with Microporous Spongelike Ultrabuoy for Long-Term 3D Mapping of Cellular Behaviors and Functions
ACS Nano (IF 13.903) Pub Date : 2019-06-24 ,DOI:10.1021/acsnano.9b02291
Real-time monitoring of cellular behaviors and functions with sensor-instrumented scaffolds can provide a profound impact on fundamental studies of the underlying biophysics and disease modeling. ...
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
Nature Communications (IF 11.878) Pub Date : 2019-05-21 ,DOI:10.1038/s41467-019-08620-4
Here we report the discovery of human-cGAS-specific small-molecule inhibitors by high-throughput screening and the targeted medicinal chemistry optimization for two molecular scaffolds. Lead compounds from one scaffold co-crystallize with human cGAS and occupy the ATP- and GTP-binding active site. ...
Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction
Nature Communications (IF 11.878) Pub Date : 2019-04-15 ,DOI:10.1038/s41467-019-09587-y
Injectable biopolymer hydrogels have gained attention for use as scaffolds to promote cardiac function and prevent negative left ventricular (LV) remodeling post-myocardial infarction (MI). ...
Toward Precise Manipulation of DNA–Protein Hybrid Nanoarchitectures
Small (IF 10.856) Pub Date : 2019-01-15 ,DOI:10.1002/smll.201804044
Particular attention is paid to site‐selectivity within DNA–protein conjugates, regulation of protein orientation using DNA scaffolds, and coassembly principles upon unique structural motifs. ...
Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness
Nature Communications (IF 11.878) Pub Date : 2019-12-05 ,DOI:10.1038/s41467-019-13522-6
African trypanosomiasis is a disease caused by Trypanosoma brucei parasites with limited treatment options. Trypanosoma is unable to synthesize purines de novo and relies solely on their uptake and interconversion from the host, constituting purine nucleoside analogues a potential source of antitrypanosomal agents. Here we combine structural elements from known trypanocidal nucleoside analogues to develop a series of 3’-deoxy-7-deazaadenosine nucleosides, and investigate their effects against African trypanosomes. 3’-Deoxytubercidin is a highly potent trypanocide in vitro and displays curative activity in animal models of acute and CNS-stage disease, even at low doses and oral administration. Whole-genome RNAi screening reveals that the P2 nucleoside transporter and adenosine kinase are involved in the uptake and activation, respectively, of this analogue. This is confirmed by P1 and P2 transporter assays and nucleotide pool analysis. 3’-Deoxytubercidin is a promising lead to treat late-stage sleeping sickness. ...
Black Phosphorus Hydrogel Scaffolds Enhance Bone Regeneration via a Sustained Supply of Calcium-Free Phosphorus
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-11 ,DOI:10.1021/acsami.8b21179
Effective bone regeneration remains a challenge for bone-tissue engineering. In this study, we propose a new strategy to accelerate bone regeneration via a sustained supply of phosphorus without providing foreign calcium. Herein, a black phosphorus nanosheet (BPN)-based hydrogel platform was developed, and the BPNs were used to stably and mildly provide phosphorus. The hydrogel was fabricated by photo-crosslinking of gelatin methacrylamide, BPNs, and cationic arginine-based unsaturated poly(ester amide)s. This platform combines the following advantages: the hydrogel scaffold would keep BPNs inside, and the encapsulated BPNs can degrade into phosphorus ions and capture calcium ions to accelerate biomineralization in a bone defect. The introduction of BPNs helped to enhance the mechanical performance of hydrogels, photoresponsively release phosphate, and accelerate mineralization in vitro. Moreover, BPN-containing hydrogels improved osteogenic differentiation of human dental pulp stem cells via the bone morphogenic protein–runt-related transcription factor 2 pathway. In vivo results from a rabbit model of bone defects revealed that the BPNs helped to accelerate bone regeneration. All these results strongly suggest that the strategy of a sustained supply of calcium-free phosphorus and this BPN-containing hydrogel platform hold promise for effective bone regeneration. ...
Engineering the Interface: Nanodiamond Coating on 3D-Printed Titanium Promotes Mammalian Cell Growth and Inhibits Staphylococcus aureus Colonization
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-28 ,DOI:10.1021/acsami.9b07064
Here, we show that applying a nanodiamond (ND) coating onto SLM-Ti scaffolds provides an improved surface for mammalian cell growth while inhibiting colonization of Staphylococcus aureus bacteria. Owing to the simplicity of our methodology, the approach is suitable for coating SLM-Ti geometries. ...
Promoting Neurite Growth and Schwann Cell Migration by the Harnessing Decellularized Nerve Matrix onto Nanofibrous Guidance
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-30 ,DOI:10.1021/acsami.9b01066
Synergistic intercellular interactions have been widely acknowledged in tuning functional cell behaviors in vivo, and these interactions have inspired the development of a variety of scaffolds for regenerative medicine. ...
Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response
Nature Communications (IF 11.878) Pub Date : 2019-04-01 ,DOI:10.1038/s41467-019-09453-x
Integrins are components of cell-matrix adhesions, and function as scaffolds for various signal transduction pathways. So far no lipid ligand for integrin has been reported. ...
Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies
Nature Communications (IF 11.878) Pub Date : 2019-02-27 ,DOI:10.1038/s41467-019-08876-w
Scaffolds displaying the four CONEs are examined for structure and immunogenicity. Crystal structures of two designed proteins reflect the computational models and accurately mimic the native conformations of CONEs. ...
Cytosolic lipid droplets as engineered organelles for production and accumulation of terpenoid biomaterials in leaves
Nature Communications (IF 11.878) Pub Date : 2019-02-20 ,DOI:10.1038/s41467-019-08515-4
We show that anchoring of distinct biosynthetic steps onto the surface of lipid droplets leads to efficient production of terpenoid scaffolds and functionalized terpenoids. The co-produced lipid droplets “trap” the terpenoids in the cells. ...
Chromosome conformation capture resolved near complete genome assembly of broomcorn millet
Nature Communications (IF 11.878) Pub Date : 2019-01-25 ,DOI:10.1038/s41467-018-07876-6
The 18 super scaffolds cover ~95.6% of the estimated genome (~887.8 Mb). There are 63,671 protein-coding genes annotated in this tetraploid genome. ...
Tissue engineered human prostate microtissues reveal key role of mast cell-derived tryptase in potentiating cancer-associated fibroblast (CAF)-induced morphometric transition in vitro
Biomaterials (IF 10.273) Pub Date : 2019-01-02 ,DOI:10.1016/j.biomaterials.2018.12.030
Primary patient-derived cancer-associated fibroblasts (CAFs) were cultured in three-dimensional (3D) melt electrowritten scaffolds where they deposited extensive extracellular matrix (ECM) and promoted significant changes in prostate epithelial morphology, when compared to matched non-malignant prostatic ...
Cell Delivery: Enhanced In Vivo Delivery of Stem Cells using Microporous Annealed Particle Scaffolds (Small 39/2019)
Small (IF 10.856) Pub Date : 2019-09-25 ,DOI:10.1002/smll.201970208
In article number 1903147, Philip O. Scumpia, Dino Di Carlo, and co‐workers co‐inject microgel particles with cells, which are covalently linked in situ to form a microporous scaffold for enhanced cell therapies. ...
Concentrically Integrative Bioassembly of a Three-Dimensional Black Phosphorus Nanoscaffold for Restoring Neurogenesis, Angiogenesis, and Immune Homeostasis
Nano Letters (IF 12.279) Pub Date : 2019-12-02 ,DOI:10.1021/acs.nanolett.9b03980
These results provide new insight into the regenerative capability of manufactured 3D scaffolds using neuroengineered 2D black phosphorus nanomaterials. ...
Metal‐Layer Assisted Growth of Ultralong Quasi‐2D MOF Nanoarrays on Arbitrary Substrates for Accelerated Oxygen Evolution
Small (IF 10.856) Pub Date : 2019-11-25 ,DOI:10.1002/smll.201906086
The MOF nanoarrays grown on porous metal scaffolds demonstrate high electrocatalytic capability for water oxidation, exhibiting a small overpotential of 270 mV at 10 mA cm−2, or 317 mV at 50 mA cm−2 as well as negligible decay of performance within 30 h. ...
Expanding the limits of the second genetic code with ribozymes
Nature Communications (IF 11.878) Pub Date : 2019-11-08 ,DOI:10.1038/s41467-019-12916-w
Here we report the systematic synthesis of 37 substrates based on 4 chemically diverse scaffolds(phenylalanine, benzoic acid, heteroaromatic, and aliphatic monomers) with different electronic and steric factors. ...
Bone-Inspired Mineralization with Highly Aligned Cellulose Nanofibers as Template
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-04 ,DOI:10.1021/acsami.9b15234
Compared with the nonaligned mineralized bacterial cellulose (NMBC) composite with mineralized crystals of HAP randomly distributed into the BC scaffolds, the AMBC composite possessed a 210% higher elastic modulus and 95% higher hardness. ...
The chromosome-scale reference genome of black pepper provides insight into piperine biosynthesis
Nature Communications (IF 11.878) Pub Date : 2019-10-16 ,DOI:10.1038/s41467-019-12607-6
The 761.2 Mb sequences (45 scaffolds with an N50 of 29.8 Mb) are assembled into 26 pseudochromosomes. ...
Bioinspired Nacre‐Like Alumina with a Metallic Nickel Compliant Phase Fabricated by Spark‐Plasma Sintering
Small (IF 10.856) Pub Date : 2019-05-27 ,DOI:10.1002/smll.201900573
Theoretical modeling has predicted that use of metallic mortars could lead to even higher damage‐tolerance in these materials, although it is difficult to melt‐infiltrate metals into ceramic scaffolds as they cannot readily wet ceramics. ...
Structure–Activity Relationships of Hierarchical Three-Dimensional Electrodes with Photosystem II for Semiartificial Photosynthesis
Nano Letters (IF 12.279) Pub Date : 2019-02-11 ,DOI:10.1021/acs.nanolett.8b04935
Confocal fluorescence microscopy and in situ surface-sensitive infrared spectroscopy are employed to probe the enzyme distribution and penetration within electrode scaffolds of different structures, which is further correlated with protein film-photoelectrochemistry to establish relationships between ...
Hydrogel Nanospike Patch as a Flexible Anti-Pathogenic Scaffold for Regulating Stem Cell Behavior
ACS Nano (IF 13.903) Pub Date : 2019-09-18 ,DOI:10.1021/acsnano.9b04109
However, their rigid mechanical properties and complex fabrication processes hinder their integration onto flexible, tissue-adaptable, and large-area patch-type scaffolds, limiting their practical applications. ...
Alfalfa Nanofibers for Dermal Wound Healing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-09 ,DOI:10.1021/acsami.9b07626
The scaffolds presented herein were built from composite alfalfa and polycaprolactone (PCL) nanofibers with hydrophilic surface and mechanical stiffness that recapitulate the physiological microenvironments of skin. ...
High-Aspect-Ratio Semiconducting Polymer Pillars for 3D Cell Cultures
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-29 ,DOI:10.1021/acsami.9b08822
Hybrid interfaces between living cells and nano/microstructured scaffolds have huge application potential in biotechnology, spanning from regenerative medicine and stem cell therapies to localized drug delivery and from biosensing and tissue engineering to neural computing. ...
Covalently-assembled single-chain protein nanostructures with ultra-high stability
Nature Communications (IF 11.878) Pub Date : 2019-07-25 ,DOI:10.1038/s41467-019-11285-8
These single-chain nanostructures also display ultra-high thermostability, resist denaturation by chaotropes and organic solvents, and have applicability as scaffolds for assembling materials with nanometer resolution. ...
Artificial coiled coil biomineralisation protein for the synthesis of magnetic nanoparticles
Nature Communications (IF 11.878) Pub Date : 2019-06-28 ,DOI:10.1038/s41467-019-10578-2
This study demonstrates how displaying active loops from membrane proteins on coiled-coil scaffoldsremoves membrane protein solubility issues, while retains activity, enabling a generic approach to readily-expressible, versatile, artificial membrane proteins for more accessible study and exploitation ...
Combining 3D single molecule localization strategies for reproducible bioimaging
Nature Communications (IF 11.878) Pub Date : 2019-04-30 ,DOI:10.1038/s41467-019-09901-8
Its insensitivity to these unavoidable experimental biases is especially adapted for multicolor 3D super-resolution microscopy, as we demonstrate by imaging cell cytoskeleton, living bacteria membranes and axon periodic submembrane scaffolds. ...
Three-Dimensional Objects Consisting of Hierarchically Assembled Nanofibers with Controlled Alignments for Regenerative Medicine
Nano Letters (IF 12.279) Pub Date : 2019-02-22 ,DOI:10.1021/acs.nanolett.9b00217
The porous objects can serve as scaffolds, guiding the organization of cells and producing highly ordered 3D tissue constructs. Additionally, subcutaneous implantation in rats demonstrates that the 3D objects enable rapid cell penetration, new blood vessel formation, and collagen matrix deposition. ...
Retraction notice to: "Biomechanical and biocompatibility characteristics of electrospun polymeric tracheal scaffolds "[BIOMATERIALS 35/20 (2014) 5307-5315].
Biomaterials (IF 10.273) Pub Date : 2019-02-19 ,DOI:10.1016/j.biomaterials.2019.02.003


Enhancement and orchestration of osteogenesis and angiogenesis by a dual-modular design of growth factors delivery scaffolds and 26SCS decoration
Biomaterials (IF 10.273) Pub Date : 2019-12-13 ,DOI:10.1016/j.biomaterials.2019.119645
Preserving the bioactivity of growth factors (GFs) and mimicking their in vivo supply patterns are challenging in the development of GFs-based bone grafts. In this study, we develop a 2-N, 6-O-sulfated chitosan (26SCS) functionalized dual-modular scaffold composed of mesoporous bioactive glass (MBG) with hierarchical porous structures (module I) and GelMA hydrogel columns (module II) in situ fixed in hollowed channels of the module I, which is capable of realizing differentiated delivery modes for osteogenic rhBMP-2 and angiogenic VEGF. A combinational release profile consisting of a high concentration of VEGF initially followed by a decreasing concentration over time, and a slower/sustainable release of rhBMP-2 is realized by immobilizing rhBMP-2 in module I and embedding VEGF in module II. Systematic in vitro and in vivo studies prove that the two coupled processes of osteogenesis and angiogenesis are well-orchestrated and both enhanced ascribed to the specific GFs delivery modes and 26SCS decoration. 26SCS not only enhances the GFs’ bioactivity but also decreases antagonism effects of noggin. This study highlights the importance of differentiating the delivery pattern of different GFs and likely sheds light on the future design of growth factor-based bone grafts. ...
PCL-MECM-Based Hydrogel Hybrid Scaffolds and Meniscal Fibrochondrocytes Promote Whole Meniscus Regeneration in a Rabbit Meniscectomy Model
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-22 ,DOI:10.1021/acsami.9b13611
Regeneration of an injured meniscus continues to be a scientific challenge due to its poor self-healing potential. Tissue engineering provides an avenue for regenerating a severely damaged meniscus. In this study, we first investigated the superiority of five concentrations (0%, 0.5%, 1%, 2%, and 4%) of meniscus extracellular matrix (MECM)-based hydrogel in promoting cell proliferation and the matrix-forming phenotype of meniscal fibrochondrocytes (MFCs). We found that the 2% group strongly enhanced chondrogenic marker mRNA expression and cell proliferation compared to the other groups. Moreover, the 2% group showed the highest glycosaminoglycan (GAG) and collagen production by day 14. We then constructed a hybrid scaffold by 3D printing a wedge-shaped poly(ε-caprolactone) (PCL) scaffold as a backbone, followed by injection with the optimized MECM-based hydrogel (2%), which served as a cell delivery system. The hybrid scaffold (PCL-hydrogel) clearly yielded favorable biomechanical properties close to those of the native meniscus. Finally, PCL scaffold, PCL-hydrogel, and MFCs-loaded hybrid scaffold (PCL-hydrogel-MFCs) were implanted into the knee joints of New Zealand rabbits that underwent total medial meniscectomy. Six months postimplantation we found that the PCL-hydrogel-MFCs group exhibited markedly better gross appearance and cartilage protection than the PCL scaffold and PCL-hydrogel groups. Moreover, the regenerated menisci in the PCL-hydrogel-MFCs group had similar histological structures, biochemical contents, and biomechanical properties as the native menisci in the sham operation group. In conclusion, PCL-MECM-based hydrogel hybrid scaffold seeded with MFCs can successfully promote whole meniscus regeneration, and cell-loaded PCL-MECM-based hydrogel hybrid scaffold may be a promising strategy for meniscus regeneration in the future. ...
Porous, pH-Responsive, and Reusable Hydrogel Beads of Bovine Serum Albumin_Au Hybrid as Smart Nanofactories for the Removal of Organic and Inorganic Pollutants from Water: A Detailed Demonstration by Spectroscopy and Microscopy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-19 ,DOI:10.1021/acsami.8b20027
This brings in a need to design molecular scaffolds suitable for efficient adsorption of the contaminants present in water. ...
In Situ Intercalation of Bismuth into 3D Reduced Graphene Oxide Scaffolds for High Capacity and Long Cycle‐Life Energy Storage
Small (IF 10.856) Pub Date : 2019-11-26 ,DOI:10.1002/smll.201905903
Metal anodes, such as zinc and bismuth have been regarded as ideal materials for aqueous batteries due to high gravimetrical capacity, high abundance, low toxicity, and intrinsic safety. However, their translation into practical applications are hindered by the low mass loading (≈1 mg cm−2) of active materials. Here, the multiscale integrated structural engineering of 3D scaffold and active material, i.e., bismuth is in situ intercalated in reduced graphene oxide (rGO) wall of network, are reported. Tailoring the rapid charge transport on rGO 3D network and facile access to nano‐ and microscale bismuth, the rGO/Bi hybrid anode shows high utilization efficiency of 91.4% at effective high load density of ≈40 mg cm−2, high areal capacity of 3.51 mAh cm−2 at the current density of 2 mA cm−2 and high reversibility of >10 000 cycles. The resulting Ni‐Bi full battery exhibits high areal capacity of 3.13 mAh cm−2 at the current density of 2 mA cm−2, far outperforming the other counterpart batteries. It represents a general and efficient strategy in enhancing the battery performance by designing hierarchically networked structure. ...
Scaffolds biomimicking macrophages for a glioblastoma NIR-Ib imaging guided photothermal therapeutic strategy by crossing Blood-Brain Barrier
Biomaterials (IF 10.273) Pub Date : 2019-05-06 ,DOI:10.1016/j.biomaterials.2019.04.026
Glioblastoma (GBM) is one of the most malignant cancers, and Blood-Brain Barrier (BBB) is the main obstacle to diagnose and treat GBM, hence scientists are making great efforts to develop new drugs which can pass BBB and integrate diagnosis and therapeutics together. Here, we designed plasma membrane of macrophage camouflaged DSPE-PEG loaded near-infrared Ib (NIR-Ib) fluorescence dye IR-792 nanoparticles (MDINPs). MDINPs were able to penetrate BBB and selectively accumulate at tumor site, and then could be used as NIR-Ib fluorescence probes for targeted tumor imaging. At the same time, MDINPs could kill tumor cells by photothermal effect. Our results showed that MDINPs-mediated NIR-Ib fluorescence imaging could clearly observe orthotopic GBM, and the NIR-Ib imaging-guided photothermal therapy significantly suppressed the growth of GBM and prolonged the life of mice. This work not only provided a method to mimic the biological function of macrophage, but also provided an integrative strategy for diagnosis and treatment in GBM. ...
Substrate curvature as a cue to guide spatiotemporal cell and tissue organization
Biomaterials (IF 10.273) Pub Date : 2019-12-27 ,DOI:10.1016/j.biomaterials.2019.119739
Elucidating how geometry affects cell and tissue behavior is, indeed, crucial to design artificial scaffoldsand understand tissue growth and remodeling. ...
Glycosaminoglycan-based hydrogels with programmable host reactions
Biomaterials (IF 10.273) Pub Date : 2019-10-23 ,DOI:10.1016/j.biomaterials.2019.119557
Adjusting of the physical properties, biofunctionalization, and degradability allowed to program the host response from nearly no degradation and infiltration to fast integration of the gel scaffolds into the tissue within days. ...
Effect of Hierarchical Scaffold Consisting of Aligned dECM Nanofibers and Poly(lactide-co-glycolide) Struts on the Orientation and Maturation of Human Muscle Progenitor Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-16 ,DOI:10.1021/acsami.9b12639
The multiscale dECM-MA/PLGA composite scaffold significantly promoted the cellular orientation and myotube formation of human muscle progenitor cells compared to control scaffolds. ...
Microfluidics‐Assisted Assembly of Injectable Photonic Hydrogels toward Reflective Cooling
Small (IF 10.856) Pub Date : 2019-08-30 ,DOI:10.1002/smll.201903939
The photonic supraballs derived from the microfluidics techniques, exhibit excellent compatibility with the hydrogel scaffolds, leading to enhanced assembly efficiency. ...
Hierarchically Porous Hydroxyapatite Hybrid Scaffold Incorporated with Reduced Graphene Oxide for Rapid Bone Ingrowth and Repair
ACS Nano (IF 13.903) Pub Date : 2019-08-07 ,DOI:10.1021/acsnano.9b04723
The hierarchical porous HA/rGO composite scaffolds can greatly accelerate the bone ingrowth in the scaffold and bone repair in critical bone defects, thus providing a clinical potential candidate for large segment bone tissue engineering. ...
Thermosensitive Display of Carbohydrate Ligands on Microgels for Switchable Binding of Proteins and Bacteria
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-19 ,DOI:10.1021/acsami.9b08537
Compared to existing switchable scaffolds, microgels nearly entirely composed of a thermosensitive material undergo a large change in volume, which allows them to drastically vary the density of ligands to switch between capture and release. ...
A Mussel‐Inspired Persistent ROS‐Scavenging, Electroactive, and Osteoinductive Scaffold Based on Electrochemical‐Driven In Situ Nanoassembly
Small (IF 10.856) Pub Date : 2019-05-20 ,DOI:10.1002/smll.201805440
This study provides a new strategy for functionalizing porous scaffolds that show great promise as implants for tissue regeneration. ...
Electrospun Nanofiber-Based Patches for the Delivery of Cardiac Progenitor Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-07 ,DOI:10.1021/acsami.9b04473
One promising avenue to combat this RVHF is the use of cardiac patches composed of stem cells and scaffolds. Herein, we demonstrate a reparative cardiac patch by combining neonatal or child c-kit+ progenitor cells (CPCs) with a scaffold composed of electrospun polycaprolactone nanofibers. ...
Photo-Cross-Linked Poly(ethylene glycol) Diacrylate Hydrogels: Spherical Microparticles to Bow Tie-Shaped Microfibers
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-09 ,DOI:10.1021/acsami.9b05555
Adult hippocampal stem/progenitor cells and bone-marrow-derived multipotent mesenchymal stromal cells were seeded onto the fibrous scaffolds in vitro, and cellular adhesion, proliferation, and differentiation were investigated. ...
Combinatorial presentation of cartilage-inspired peptides on nanopatterned surfaces enables directed differentiation of human mesenchymal stem cells towards distinct articular chondrogenic phenotypes
Biomaterials (IF 10.273) Pub Date : 2019-04-25 ,DOI:10.1016/j.biomaterials.2019.04.003
A greater understanding of the impacts of the extracellular cues provided in each zone of articular cartilage on hMSCs thus offers the potential to develop new scaffolds that can effect multi-zonal cartilage generation. ...
Mesenchymal Stem Cell Capping on ECM‐Anchored Caspase Inhibitor–Loaded PLGA Microspheres for Intraperitoneal Injection in DSS‐Induced Murine Colitis
Small (IF 10.856) Pub Date : 2019-04-24 ,DOI:10.1002/smll.201901269
Extracellular matrix (ECM)‐coated scaffolds provide better cell attachment and mechanical support for MSCs after transplantation. ...
Design and Characterization of RNA Nanotubes
ACS Nano (IF 13.903) Pub Date : 2019-04-22 ,DOI:10.1021/acsnano.8b09421
Nanotubes assemble also from RNA tiles modified to include a single-stranded overhang (toehold), suggesting that it may be possible to decorate these large RNA scaffolds with nanoparticles or other nucleic acid molecules. ...
Poly(propylene fumarate)-based materials: Synthesis, functionalization, properties, device fabrication and biomedical applications
Biomaterials (IF 10.273) Pub Date : 2019-03-28 ,DOI:10.1016/j.biomaterials.2019.03.038
In particular, the use of 3D printing techniques for the fabrication of PPF-based scaffolds is extensively reviewed. The recent invention of a ring-opening polymerization method affords precise control of PPF molecular mass, molecular mass distribution (ƉM) and viscosity. ...
Synchronous delivery of hydroxyapatite and connective tissue growth factor derived osteoinductive peptide enhanced osteogenesis
Journal of Controlled Release (IF 7.901) Pub Date : 2019-03-14 ,DOI:10.1016/j.jconrel.2019.02.037
In bone tissue engineering, electrospun fibrous scaffolds can provide excellent mechanical support, extracellular matrix mimicking components, such as 3D spacial fibrous environment for cell growth and controlled release of signaling molecules for osteogenesis. ...
Controlled Anchoring of Iron Oxide Nanoparticles on Polymeric Nanofibers: Easy Access to Core@Shell Organic–Inorganic Nanocomposites for Magneto-Scaffolds
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-20 ,DOI:10.1021/acsami.8b19099
Composites combining superparamagnetic iron oxide nanoparticles (SPIONs) and polymers are largely present in modern (bio)materials. However, although SPIONs embedded in polymer matrices are classically reported, the mechanical and degradation properties of the polymer scaffold are impacted by the SPIONs. Therefore, the controlled anchoring of SPIONs onto polymer surfaces is still a major challenge. Herein, we propose an efficient strategy for the direct and uniform anchoring of SPIONs on the surface of functionalized-polylactide (PLA) nanofibers via a simple free ligand exchange procedure to design PLA@SPIONs core@shell nanocomposites. The resulting PLA@SPIONs hybrid biomaterials are characterized by electron microscopy (scanning electron microscopy and transmission electron microscopy) and energy-dispersive X-ray spectroscopy analysis to probe the morphology and detect elements present at the organic–inorganic interface, respectively. A monolayer of SPIONs with a complete and homogeneous coverage is observed on the surface of PLA nanofibers. Magnetization experiments show that magnetic properties of the nanoparticles are well preserved after their grafting on the PLA fibers and that the size of the nanoparticles does not change. The absence of cytotoxicity, combined with a high sensitivity of detection in magnetic resonance imaging both in vitro and in vivo, makes these hybrid nanocomposites attractive for the development of magnetic biomaterials for biomedical applications. ...
The Regulatory Functionality of Exosomes Derived from hUMSCs in 3D Culture for Alzheimer's Disease Therapy
Small (IF 10.856) Pub Date : 2019-12-16 ,DOI:10.1002/smll.201906273
However, there are few reports addressing whether exosomes derived from cells cultured on scaffoldswith varying dimension can reduce Aβ deposition or ameliorate cognitive decline for AD therapy. ...
Enhanced Catalysis from Multienzyme Cascades Assembled on a DNA Origami Triangle
ACS Nano (IF 13.903) Pub Date : 2019-11-21 ,DOI:10.1021/acsnano.9b05746
DNA nanostructures have been suggested as ideal scaffolds for assembling sequential enzymatic cascades in close enough proximity to potentially allow for exploiting of channeling effects; however, initial demonstrations have provided somewhat contradictory results toward confirming this phenomenon. ...
Assessment of Oligo-Chitosan Biocompatibility toward Human Spermatozoa
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-09 ,DOI:10.1021/acsami.9b17605
The many interesting properties of chitosan polysaccharides have prompted their extensive use as biomaterial building blocks, for instance as antimicrobial coatings, tissue engineering scaffolds, and drug delivery vehicles. ...
Microribbon-hydrogel composite scaffold accelerates cartilage regeneration in vivo with enhanced mechanical properties using mixed stem cells and chondrocytes
Biomaterials (IF 10.273) Pub Date : 2019-10-31 ,DOI:10.1016/j.biomaterials.2019.119579
The composite scaffold is comprised of a macroporous, gelatin microribbon (μRB) scaffolds filled with degradable nanoporous chondroitin sulfate (CS) hydrogel. We identified an optimal CS concentration (6%) that best supported co-culture synergy in vitro. ...
3D bioengineered tissue model of the large intestine to study inflammatory bowel disease
Biomaterials (IF 10.273) Pub Date : 2019-09-25 ,DOI:10.1016/j.biomaterials.2019.119517
An intestinal epithelial layer comprised of non-transformed human colon organoid cells and a subepithelial layer laden with monocyte-derived macrophages was bioengineered to mimic native intestinal mucosa cell organization using spongy biomaterial scaffolds. ...
Simultaneous nano- and microscale structural control of injectable hydrogels via the assembly of nanofibrous protein microparticles for tissue regeneration
Biomaterials (IF 10.273) Pub Date : 2019-08-29 ,DOI:10.1016/j.biomaterials.2019.119458
Injectable hydrogels are advantageous as tissue regeneration scaffolds, as they can be delivered through a minimally invasive injection and seamlessly integrate with the target tissues. ...
Influence of hyaluronic acid modification on CD44 binding towards the design of hydrogel biomaterials
Biomaterials (IF 10.273) Pub Date : 2019-08-23 ,DOI:10.1016/j.biomaterials.2019.119451
HA has been extensively explored as a chemically-modified macromer for crosslinking into biomaterials, such as hydrogels and macroporous scaffolds. However, the influence of the extent and type of HA modification on its binding to CD44 is not well understood or quantified. ...
Water-in-PDMS Emulsion Templating of Highly Interconnected Porous Architectures for 3D Cell Culture
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-02 ,DOI:10.1021/acsami.9b07564
These results open alternative scenarios for the fabrication and integration of porous scaffolds for the development of 3D cell culture platforms. ...
Sn-Triggered Two-Dimensional Fast Protein Assembly with Emergent Functions
ACS Nano (IF 13.903) Pub Date : 2019-06-20 ,DOI:10.1021/acsnano.9b01392
The hybrid film is distinctive in its ease of coating on versatile material surfaces with endurable chemical and mechanical stability, optical transparency, and diverse end uses in antimicrobial and photo-/electrocatalytic scaffolds. ...
Self-Assembly of Metallo-Nucleoside Hydrogels for Injectable Materials That Promote Wound Closure
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-22 ,DOI:10.1021/acsami.9b02265
Injectable hydrogels are increasingly being used as scaffolds for in situ tissue engineering and wound healing. Most of these injectable hydrogels are made from polymers, and there are fewer examples of such soft materials made via self-assembly of low-molecular weight gelators. ...
Femtosecond Mathieu Beams for Rapid Controllable Fabrication of Complex Microcages and Application in Trapping Microobjects
ACS Nano (IF 13.903) Pub Date : 2019-03-19 ,DOI:10.1021/acsnano.9b00893
Finally, culturing of budding yeasts is investigated with these microcages, which demonstrates its application as 3D cell culture scaffolds. ...
Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids
Biomaterials (IF 10.273) Pub Date : 2019-01-22 ,DOI:10.1016/j.biomaterials.2019.01.028
To mimic this phenomenon in vitro, tissue decellularisation approaches have been developed, resulting in the generation of natural ECM scaffolds that have comparable physical and biochemical properties of the natural tissues and are currently gaining traction in tissue engineering and regenerative therapies ...
Copper Silicide Nanowires as Hosts for Amorphous Si Deposition as a Route to Produce High Capacity Lithium-Ion Battery Anodes
Nano Letters (IF 12.279) Pub Date : 2019-11-05 ,DOI:10.1021/acs.nanolett.9b03664
The conductive Cu15Si4 NW scaffolds offer an increased surface area, versus planar substrates, and enable the preparation of high capacity Li-ion anodes consisting of a nanostructured active material. ...
Progress in 3D bioprinting technology for tissue/organ regenerative engineering
Biomaterials (IF 10.273) Pub Date : 2019-10-11 ,DOI:10.1016/j.biomaterials.2019.119536
In this review, we outline recent progress in several bioprinting technologies used to engineer scaffoldswith requisite mechanical, structural, and biological complexity. ...
First Aldol Cross-Linked Hyaluronic Acid Hydrogel: Fast and Hydrolytically Stable Hydrogel with Tissue Adhesive Properties
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-04 ,DOI:10.1021/acsami.9b10239
Currently, there are limited approaches to tailor 3D scaffolds cross-linked with a stable covalent C–C bond that does not require any catalysts or initiators. We present here the first hydrogels employing aldol condensation chemistry that exhibit exceptional physicochemical properties. ...
Comparative Study of Carbon Nanoparticles and Single-Walled Carbon Nanotube for Light-Heat Conversion and Thermal Conductivity Enhancement of the Multifunctional PEG/Diatomite Composite Phase Change Material
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-08 ,DOI:10.1021/acsami.9b04349
The emerging supporting scaffolds are then applied to a prepare polyethylene glycol (PEG)-infiltrated composite phase change material to seek an efficient but easy way to improve the thermal conductivity and synchronously accomplish the light-thermal conversion on the one hand. ...
Rational Construction of 3D‐Networked Carbon Nanowalls/Diamond Supporting CuO Architecture for High‐Performance Electrochemical Biosensors
Small (IF 10.856) Pub Date : 2019-05-10 ,DOI:10.1002/smll.201901527
Besides, the vertical aligned diamond nanoplatelet scaffolds could improve structural and mechanical stability of the designed electrode in long‐term performance. ...
Antifreezing Heat-Resistant Hollow Hydrogel Tubes
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-08 ,DOI:10.1021/acsami.9b03892
Hollow hydrogel tubes that are capable of maintaining their flexibility and structural stability in extreme temperature conditions have potential for use in biomedical scaffolds, carriers, and soft robotics over a wide temperature range. ...
Sub‐10 nm Ag Nanoparticles/Graphene Oxide: Controllable Synthesis, Size‐Dependent and Extremely Ultrahigh Catalytic Activity
Small (IF 10.856) Pub Date : 2019-04-26 ,DOI:10.1002/smll.201901701
The ultrafine size of the AgNPs and their surface accommodation on the unobstructed 2D GO scaffoldswithout capping reagents/covers, which make the abundantly exposed catalytically active sites highly accessible to substrate molecules, play an important role in their extremely ultrahigh performance. ...
Cucurbit[7]uril-Carbazole Two-Photon Photoinitiators for the Fabrication of Biocompatible Three-Dimensional Hydrogel Scaffolds by Laser Direct Writing in Aqueous Solutions
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-04 ,DOI:10.1021/acsami.8b15011
We have introduced a novel water-soluble two-photon photoinitiator based on the host–guest interaction between 3,6-bis[2-(1-methyl-pyridinium)vinyl]-9-pentyl-carbazole diiodide (BMVPC) and cucurbit[7]uril (CB7) because most of the commercial photoinitiators have poor two-photon initiating efficiency in aqueous solutions. The binding ratio of BMVPC and CB7 was determined as 1:1 by isothermal titration calorimetry and quantum chemical calculation. The formation of the host–guest complex increases the two-photon absorption cross-section about five times, and improves the water solubility required as the photoinitiator for hydrogel fabrication. The BMVPC–CB7 inclusion complex was used as the one-component photoinitiator, and the polyethylene glycol diacrylate with promising biocompatibility was used as the hydrogel monomer to form the aqueous-phase photoresist system applied to two-photon polymerization microfabrication. A relatively low laser threshold of 4.5 mW, a high fabricating resolution of 180 nm, and the true three-dimensional (3D) fabricating capability in the aqueous solution have been obtained by using the as-prepared photoresist system. Finally, 3D engineering hydrogel scaffold microstructures with low toxicity and good biocompatibility have been fabricated and cocultured with living HeLa cells, which demonstrates the potential for further application in tissue engineering. ...
Elastic and surgeon friendly electrospun tubes delivering PDGF-BB positively impact tendon rupture healing in a rabbit Achilles tendon model
Biomaterials (IF 10.273) Pub Date : 2019-12-23 ,DOI:10.1016/j.biomaterials.2019.119722
In vitro studies showed that both emulsion and coaxially electrospun scaffolds allow sustained delivery of bioactive PDGF-BB with similar release kinetics (150–190 pg PDGF-BB/mg of DP scaffold) over a period of 30 days. ...
An Injectable Conductive Three-Dimensional Elastic Network by Tangled Surgical-Suture Spring for Heart Repair
ACS Nano (IF 13.903) Pub Date : 2019-12-09 ,DOI:10.1021/acsnano.9b06761
Designing scaffolds with persistent elasticity and conductivity to mimic microenvironments becomes a feasible way to repair cardiac tissue. ...
Conducting and Lithiophilic MXene/Graphene Framework for High-Capacity, Dendrite-Free Lithium–Metal Anodes
ACS Nano (IF 13.903) Pub Date : 2019-12-03 ,DOI:10.1021/acsnano.9b07710
Toward this goal, suitable stable scaffolds for dendrite-free Li anodes with large current density (>5 mA cm–2) and high Li loading (>90%) are highly in demand. ...
Self-Assembled Peptide Nanofibers Display Natural Antimicrobial Peptides to Selectively Kill Bacteria without Compromising Cytocompatibility
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-02 ,DOI:10.1021/acsami.9b09583
These assemblies, with intrinsic antimicrobial activity and cytocompatibility, can also serve as building blocks for the construction of higher-ordered scaffolds for other biomedical applications such as tissue engineering and regenerative medicine. ...
Controlling the Multiscale Network Structure of Fibers To Stimulate Wound Matrix Rebuilding by Fibroblast Differentiation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-22 ,DOI:10.1021/acsami.9b06439
relationship, herein, we designed and prepared a series of biocompatible polycaprolactone (PCL)-based fibers with different fiber diameters (nano vs micro) and different alignments (random vs aligned) using a simple electrospinning process, with a particular attention to the morphological effect of PCL fiber scaffolds ...
Fabrication and Characterization of Composite Meshes Loaded with Antimicrobial Peptides
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-26 ,DOI:10.1021/acsami.9b07246
The surface morphologies, Fourier-transform infrared spectroscopy spectra, in vitro release profiles, mechanical performances, in vitro antimicrobial properties, and cytocompatibility of composite scaffoldswere evaluated. ...

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