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2019年生物纳米研究最新热点报道(六)
来源于:纳米医学网 | 作者: | 发布时间:2017-12-31 | 浏览:311


argeted delivery of antimicrobial peptide by cry protein crystal to treat intramacrophage infection
Biomaterials (IF 10.273) Pub Date : 2019-06-15 ,DOI:10.1016/j.biomaterials.2019.119286
Notably, this targeted delivery of DS1 results in enhanced in vitro and in vivo antileishmanial activity, as well as reduced toxicity to the host macrophages. These findings suggest that the Cry3Aa crystal can be an effective delivery platform for AMPs to treat intramacrophage infections. ...
Facile Fabrication of Magnetic Microrobots Based on Spirulina Templates for Targeted Delivery and Synergistic Chemo-Photothermal Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-23 ,DOI:10.1021/acsami.8b15586
Magnetic microrobots can be actuated in fuel-free conditions and are envisioned for biomedical applications related to targeted delivery and therapy in a minimally invasive manner. ...
Ultrasound and Microbubble-targeted Delivery of a microRNA Inhibitor to the Heart Suppresses Cardiac Hypertrophy and Preserves Cardiac Function.
Theranostics (IF 8.063) Pub Date : 2019-10-30 ,DOI:10.7150/thno.34895
AntimiR inhibition of miR-23a suppressed hypertension-induced cardiac hypertrophy in preclinical models, but clinical translation is limited by a lack of cardiac-targeted delivery systems. ...
Aptamer Optimization: RNA‐Capturing Microsphere Particles (R‐CAMPs) for Optimization of Functional Aptamers (Small 26/2019)
Small (IF 10.856) Pub Date : 2019-06-26 ,DOI:10.1002/smll.201970140
In article number 1805062, Naoki Sugimoto and co‐workers construct RNA‐capturing microsphereparticles (R‐CAMPs) that display RNA and DNA clones of identical sequence. ...
Targeted delivery of anti-inflammatory cytokine by nanocarrier reduces atherosclerosis in Apo E−/- mice
Biomaterials (IF 10.273) Pub Date : 2019-10-15 ,DOI:10.1016/j.biomaterials.2019.119550
In this work, we have encapsulated interleukin-10 (IL10), a multipotent anti-inflammatory cytokine into cRGD conjugated pluronic based nano-carriers (NC) for targeted delivery to atherosclerotic plaques. ...
Microsphere‐Like SiO2/MXene Hybrid Material Enabling High Performance Anode for Lithium Ion Batteries
Small (IF 10.856) Pub Date : 2019-12-23 ,DOI:10.1002/smll.201905430
Moreover, the microsphere wrapped with ductile MXene film reduces the specific surface area, relieves the side reactions, and enhances the coulombic efficiency. ...
Rod-Scale Design Strategies for Immune-Targeted Delivery System toward Cancer Immunotherapy
ACS Nano (IF 13.903) Pub Date : 2019-06-28 ,DOI:10.1021/acsnano.9b01271
The present study provides a rod-scale design strategy for an immune-targeted delivery system toward cancer immunotherapy in the future. ...
An activated-platelet-sensitive nanocarrier enables targeted delivery of tissue plasminogen activator for effective thrombolytic therapy
Journal of Controlled Release (IF 7.901) Pub Date : 2019-02-23 ,DOI:10.1016/j.jconrel.2019.02.033
Herein, we report a multifunctional liposomal system (164.6 ± 5.3 nm in diameter) for selective thrombolysis through targeted delivery and controlled release of tissue plasminogen activator (tPA) at the thrombus site. ...
Self-Assembled 2D Glycoclusters for the Targeted Delivery of Theranostic Agents to Triple-Negative Breast Cancer Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-12 ,DOI:10.1021/acsami.9b06016
Here, we develop a two-dimensional (2D) glycocluster by means of simple, stepwise self-assembly for the targeted delivery of theranostic agents to TNBC cells that express mannose receptors (MRs) on the cell surface. ...
RNA‐Capturing Microsphere Particles (R‐CAMPs) for Optimization of Functional Aptamers
Small (IF 10.856) Pub Date : 2019-02-18 ,DOI:10.1002/smll.201805062
The process relies on RNA‐capturing microsphere particles (R‐CAMPs): each particle displays different clones of identical DNA and RNA sequences. Using a fluorescence‐activated cell sorter, the R‐CAMPs that are linked to functional aptamers are sorted. ...
Antibody-Functional Microsphere-Integrated Filter Chip with Inertial Microflow for Size–Immune-Capturing and Digital Detection of Circulating Tumor Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-12 ,DOI:10.1021/acsami.9b09655
We synthesized interfacial zinc oxide coating with nanostructure on the surface of the microsphere to increase the specific surface area to enhance the capturing efficiency of CTCs. Microspheres, trapped in the arrays, would entrap CTCs, too. ...
Polysaccharide-Based Lotus Seedpod Surface-Like Porous Microsphere with Precise and Controllable Micromorphology for Ultrarapid Hemostasis
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-05 ,DOI:10.1021/acsami.9b17543
Herein, we reported a “lotus seedpod surface-like” polysaccharide hemostatic microsphere (PHM) with “macropits on surface” morphology and “micropores in macropits” structure. ...
Carrier-Enhanced Anticancer Efficacy of Sunitinib-Loaded Green Tea-Based Micellar Nanocomplex beyond Tumor-Targeted Delivery
ACS Nano (IF 13.903) Pub Date : 2019-07-08 ,DOI:10.1021/acsnano.9b00467
Although a few nanomedicines have been approved for clinical use in cancer treatment, that recognizes improved patient safety through targeted delivery, their improved efficacy over conventional drugs has remained marginal. ...
Knockdown of hypoxia-inducible factor-1 alpha by tumor targeted delivery of CRISPR/Cas9 system suppressed the metastasis of pancreatic cancer
Journal of Controlled Release (IF 7.901) Pub Date : 2019-05-14 ,DOI:10.1016/j.jconrel.2019.05.019
The targeted delivery of CRISPR/Cas9-HIF-1α system and PTX significantly inhibited tumor growth. More importantly, inhibition of HIF-1α suppressed the metastasis of pancreatic cancer and prolonged survival time. ...
Capacity Loss Mechanism of the Li4Ti5O12 Microsphere Anode of Lithium-Ion Batteries at High Temperature and Rate Cycling Conditions
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-27 ,DOI:10.1021/acsami.9b14119
Herein, the capacity loss mechanism of the high-tap density LTO microsphere anode under different temperatures (25, 45, and 60 °C) and charge/discharge rates (1 and 5 C) is systematically investigated. ...
Controllable Wrinkling Patterns on Chitosan Microspheres Generated from Self-Assembling Metal Nanoparticles
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-12 ,DOI:10.1021/acsami.9b02127
(LBL) self-assembly followed by deswelling, resulting in a surface wrinkled microsphere. ...
Ligand-Modified Cell Membrane Enables the Targeted Delivery of Drug Nanocrystals to Glioma
ACS Nano (IF 13.903) Pub Date : 2019-05-13 ,DOI:10.1021/acsnano.9b00661
The safe and efficient delivery of chemotherapeutic agents remains critical to anticancer therapy. Herein, we report on a targeted drug delivery system based upon a modified cell membrane coating technique and drug nanocrystals (NCs). Specifically, red blood cell (RBC) membrane was modified with targeting peptides through a facile insertion method involving avidin–biotin interactions. The RBC membrane-coated drug NCs (RBC-NCs) exhibited high drug loading, long-term stability, excellent biocompatibility, and prolonged retention time, all of which make them suitable for effective drug delivery. When modified with the tumor-targeting peptide c(RGDyK), the resulting RGD-RBC-NCs showed superior tumor accumulation and therapeutic efficacy both in mice bearing a subcutaneous tumor as well as orthotropic glioma. RBC-NC therapeutics can be readily generalized to the delivery of various drugs and for the treatment of a wide range of cancers. ...
Boosting Interleukin‐12 Antitumor Activity and Synergism with Immunotherapy by Targeted Delivery with isoDGR‐Tagged Nanogold
Small (IF 10.856) Pub Date : 2019-09-16 ,DOI:10.1002/smll.201903462
The clinical use of interleukin‐12 (IL12), a cytokine endowed with potent immunotherapeutic anticancer activity, is limited by systemic toxicity. The hypothesis is addressed that gold nanoparticles tagged with a tumor‐homing peptide containing isoDGR, an αvβ3‐integrin binding motif, can be exploited for delivering IL12 to tumors and improving its therapeutic index. To this aim, gold nanospheres are functionalized with the head‐to‐tail cyclized‐peptide CGisoDGRG (Iso1) and murine IL12. The resulting nanodrug (Iso1/Au/IL12) is monodispersed, stable, and bifunctional in terms of αvβ3 and IL12‐receptor recognition. Low‐dose Iso1/Au/IL12, equivalent to 18–75 pg of IL12, induces antitumor effects in murine models of fibrosarcomas and mammary adenocarcinomas, with no evidence of toxicity. Equivalent doses of Au/IL12 (a nanodrug lacking Iso1) fail to delay tumor growth, whereas 15 000 pg of free IL12 is necessary to achieve similar effects. Iso1/Au/IL12 significantly increases tumor infiltration by innate immune cells, such as NK and iNKT cells, monocytes, and neutrophils. NK cell depletion completely inhibits its antitumor effects. Low‐dose Iso1/Au/IL12 can also increase the therapeutic efficacy of adoptive T‐cell therapy in mice with autochthonous prostate cancer. These findings indicate that coupling IL12 to isoDGR‐tagged nanogold is a valid strategy for enhancing its therapeutic index and sustaining adoptive T‐cell therapy. ...
Biodegradable micro-sized discoidal polymeric particles for lung-targeted delivery system
Biomaterials (IF 10.273) Pub Date : 2019-07-05 ,DOI:10.1016/j.biomaterials.2019.119331
Various types of particle-based drug delivery systems have been explored for the treatment of pulmonary diseases; however, bio-distribution and elimination of the particles should be monitored for better understanding of their therapeutic efficacy and safety. This study aimed to characterize the biological properties of micro-sized discoidal polymeric particles (DPPs) as lung-targeted drug delivery carriers. DPPs were prepared using a top-down fabrication approach and characterized by assessing size and zeta potential. They were labeled with zirconium-89 (89Zr), and bio-distribution studies and PET imaging were performed for 7 days after intravenous administration. Their hydrodynamic size was 2.8 ± 6.1 μm and average zeta potential was −39.9 ± 5.39 mV. At doses of 5, 12.5, and 25 mg/kg, they showed no acute toxicity in nude mice. Desferrioxamine (DFO)-functionalized 89Zr-labeled DPPs gave a decay-corrected radiochemical yield of 82.1 ± 0.2%. Furthermore, 89Zr-DPPs, from chelate-free labeling methods, showed a yield of 48.5 ± 0.9%. Bio-distribution studies and PET imaging showed 89Zr-DFO-DPPs to be mainly accumulated in the lungs and degraded within 3 d of injection. However, 89Zr-DFO-DPPs showed significantly low uptake in the bone. Overall, our results suggested micro-sized DPPs as promising drug delivery carriers for the targeted treatment of various pulmonary diseases. ...
Development of Level A in vitro-in vivo correlations for peptide loaded PLGA microspheres
Journal of Controlled Release (IF 7.901) Pub Date : 2019-07-10 ,DOI:10.1016/j.jconrel.2019.07.013
Peptide loaded PLGA microsphere products are more complex in terms of manufacturing, drug release characteristics as well as release mechanism compared to small molecule loaded PLGA microsphereproducts. ...
Breathable Nanowood Biofilms as Guiding Layer for Green On‐Skin Electronics
Small (IF 10.856) Pub Date : 2019-06-04 ,DOI:10.1002/smll.201901079
The porous biofilms are competent in applications where “sensitive” biosensing (transporting// sweat up to 11.25 mm s−1 at the 1st second), “insulating” between units, and “targeted” delivery of saline‐soluble drugs are of uppermost priority. ...
Targeted Delivery of Cisplatin-Derived Nanoprecursors via a Biomimetic Yeast Microcapsule for Tumor Therapy by the Oral Route
Theranostics (IF 8.063) Pub Date : 2019-08-21 ,DOI:10.7150/thno.35353
Targeted therapy via the patient-friendly oral route remains the holy grail of chemotherapy for cancer. Herein we report a yeast-derived platform for targeted oral delivery of cisplatin (CDDP) that is one of the most effective drugs for chemotherapy of various types of cancers. Methods: The optimal conditions were first established to fabricate yeast microcapsules (YCs) with desirable loading capability. Then, CDDP-derived precursor nanoparticles (PreCDDP) were prepared and packaged into YC to produce orally deliverable PreCDDP/YC. The physiochemical properties, in vitro drug release profiles, in vitro antitumor activity, oral targeting capability, in vivo pharmacokinetics, and in vivo efficacy of the YC-based biomimetic delivery system were examined. Results: YCs obtained under the optimized condition showed desirable loading efficiency for quantum dots that were used as a model nanocargo. In vitro experiments demonstrated rapid endocytosis and prolonged retention of YC in macrophages. By electrostatic force-mediated self-deposition, PreCDDP was efficiently loaded into YC. PreCDDP/YC showed potent cytotoxicity in different tumor cells, indicating that PreCDDP loaded in YC maintained its antitumor activity after intracellular release. As compared to CDDP and PreCDDP, orally administered PreCDDP/YC displayed significantly higher bioavailability. Post oral delivery, YC could accumulate in A549 human lung carcinoma xenografts in mice, achieving by monocyte/macrophage-mediated translocation via the lymphatic system. Through this targeting effect, orally administered PreCDDP/YC showed desirable efficacy in A549 xenograft-bearing mice, which was comparable to that of free CDDP administered by intravenous injection. Orally administered free CDDP, however, did not afford antitumor effects. Furthermore, oral treatment with PreCDDP/YC displayed better safety than free CDDP administered via the oral or intravenous route. Conclusions: This biomimetic approach can serve as an effective strategy to develop targeted oral chemotherapies based on CDDP or its derivatives. Keywords: cisplatin, nanoprecursor, yeast microcapsule, oral delivery, targeted tumor therapy ...
Ultrasound/microbubble-mediated targeted delivery of anticancer microRNA-loaded nanoparticles to deep tissues in pigs
Journal of Controlled Release (IF 7.901) Pub Date : 2019-07-18 ,DOI:10.1016/j.jconrel.2019.07.024
In this study, we designed and validated a platform for ultrasound and microbubble-mediated delivery of FDA-approved pegylated poly lactic-co-glycolic acid (PLGA) nanoparticles loaded with anticancer microRNAs (miRNAs) to deep tissues in a pig model. Small RNAs have been shown to reprogram tumor cells and sensitize them to clinically used chemotherapy. To overcome their short intravascular circulation half-life and achieve controlled and sustained release into tumor cells, anticancer miRNAs need to be encapsulated into nanocarriers. Focused ultrasound combined with gas-filled microbubbles provides a noninvasive way to improve the permeability of tumor vasculature and increase the delivery efficiency of drug-loaded particles. A single handheld, curvilinear ultrasound array was used in this study for image-guided therapy with clinical-grade SonoVue contrast agent. First, we validated the platform on phantoms to optimize the microbubble cavitation dose based on acoustic parameters, including peak negative pressure, pulse length, and pulse repetition frequency. We then tested the system in vivo by delivering PLGA nanoparticles co-loaded with antisense-miRNA-21 and antisense-miRNA-10b to pig liver and kidney. Enhanced miRNA delivery was observed (1.9- to 3.7-fold increase) as a result of the ultrasound treatment compared to untreated control regions. Additionally, we used highly fluorescent semiconducting polymer nanoparticles to visually assess nanoparticle extravasation. Fluorescent microscopy suggested the presence of nanoparticles in the extravascular compartment. Hematoxylin and eosin staining of treated tissues did not reveal tissue damage. The results presented in this manuscript suggest that the proposed platform may be used to safely and noninvasively enhance the delivery of miRNA-loaded nanoparticles to target regions in deep organs in large animal models. ...
Significantly enhanced recovery of acute liver failure by liver targeted delivery of stem cells via heparin functionalization
Biomaterials (IF 10.273) Pub Date : 2019-04-17 ,DOI:10.1016/j.biomaterials.2019.04.019
Acute liver failure (ALF) occurs by insufficient detoxification of toxic materials in the liver, generating excess reactive oxygen species (ROS). Mesenchymal stem cell (MSC) therapy can be a promising approach for the treatment of liver diseases including ALF by anti-inflammatory activity and secretion of cytokines associated with tissue regeneration. However, the efficacy of MSC therapy is generally poor, mainly due to a low survival and engraftment of administered cells. In this study, we demonstrated that the enhanced delivery of human adipose-derived stem cells (hADSCs) to the damaged liver by the coating of lipid-conjugated heparin could result in significantly improved recovery from ALF in a mouse model. First, the therapeutic effect of secretomes of hADSCs on acetaminophen (APAP)-induced hepatic cell damage was confirmed regardless of the coating of lipid-conjugated heparin on hADSCs in vitro. Then, the therapeutic effects of lipid-conjugated heparin coated hADSCs (Lip-Hep/hADSC group) were analyzed compared to hADSCs themselves (hADSC group) using an APAP-induced ALF model in vivo. Intravenous administration of hADSCs could lower the elevated serum levels of aspartate transaminase (AST) and alanine transaminase (ALT), but Lip-Hep/hADSC group showed faster decrease in serum levels of AST and ALT to the normal values compared to hADSC group. Enhanced delivery and longer retention of hADSCs in the damage liver by the coating of lipid-conjugated heparin were confirmed by optical imaging of isolated organs using labeled cells and immunofluorescence staining of liver tissue sections again human nuclei. A significantly increased level of human hepatic growth factor (hHGF), a representative secretome from hADSC, significantly reduced levels of macrophage and CYP2E1, implying alleviated inflammatory response, were detected by immunofluorescence staining from Lip-Hep/hADSC group compared to hADSC group. These results well coincided with the improved recovery of the damaged liver from Lip-Hep/hADSC group than hADSC group in histological analysis. Thus, the coating of lipid-conjugated heparin on hADSCs has a great potential to improve the therapeutic effect of cells on the liver injury. ...
Overcoming the Reticuloendothelial System Barrier to Drug Delivery with a “Don’t-Eat-Us” Strategy
ACS Nano (IF 13.903) Pub Date : 2019-11-07 ,DOI:10.1021/acsnano.9b05679
This “don’t-eat-us” strategy by DSL was further verified on the brain-targeted delivery against a cryptococcal meningitis model, providing dramatically enhanced brain accumulation of the targeteddelivery system and superior therapeutic outcome of model drug Amphotericin B compared with CL. ...
End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug: Torpedo-Shaped Peptidic Nanocapsules
ACS Nano (IF 13.903) Pub Date : 2019-01-04 ,DOI:10.1021/acsnano.8b06189
Nanomaterial morphology is important for the targeted delivery of drugs to tissues as well as subsequent cellular uptake. ...
Graphene Armored with a Crystal Carbon Shell for Ultrahigh-Performance Potassium Ion Batteries and Aluminum Batteries
ACS Nano (IF 13.903) Pub Date : 2019-09-10 ,DOI:10.1021/acsnano.9b04893
Herein, a special crystal carbon@graphene microsphere (CCGM) composite was successfully synthesized. The scalable carbonaceous microsphere composite displays a small specific surface area and a superior structure stability. ...
GPR124 facilitates pericyte polarization and migration by regulating the formation of filopodia during ischemic injury.
Theranostics (IF 8.063) Pub Date : 2019-09-20 ,DOI:10.7150/thno.34168
Methods: A microsphere embolism-induced ischemia model was used to evaluate the expression of GPR124 following microsphere embolism. ...
Spatiotemporally controllable diphtheria toxin expression using a light-switchable transgene system combining multifunctional nanoparticle delivery system for targeted melanoma therapy
Journal of Controlled Release (IF 7.901) Pub Date : 2019-12-12 ,DOI:10.1016/j.jconrel.2019.12.015
All the above results indicated that the combination of a light-switchable transgene system with a nanoparticle-based targeted delivery system have great potentials in gene therapy of malignant tumors with improved precision and efficacy. ...
Rapid Production of Cell‐Laden Microspheres Using a Flexible Microfluidic Encapsulation Platform
Small (IF 10.856) Pub Date : 2019-08-30 ,DOI:10.1002/smll.201902058
However, existing platforms have been constrained by traditional microfabrication techniques for device fabrication, restricting microsphere diameter to below 200 µm and making iterative design changes time‐consuming and costly. ...
Three-dimensional solitary waves with electrically tunable direction of propagation in nematics
Nature Communications (IF 11.878) Pub Date : 2019-08-21 ,DOI:10.1038/s41467-019-11768-8
Besides adding a whole dimension to the propagation direction and enabling controlled steering, the solitons can lead to applications such as targeted delivery of information and micro-cargo. ...
Construction of Oxygen-Deficient La(OH)3 Nanorods Wrapped by Reduced Graphene Oxide for Polysulfide Trapping toward High-Performance Lithium/Sulfur Batteries
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-20 ,DOI:10.1021/acsami.9b06904
The robust microsphere architecture can reduce ion diffusion pathways and provide adequate space to modulate volume variation during cycling. ...
Employing Macrophage-Derived Microvesicle for Kidney-Targeted Delivery of Dexamethasone: An Efficient Therapeutic Strategy against Renal Inflammation and Fibrosis.
Theranostics (IF 8.063) Pub Date : 2019-08-02 ,DOI:10.7150/thno.33520
Although glucocorticoids are the mainstays in the treatment of renal diseases for decades, the dose dependent side effects have largely restricted their clinical use. Microvesicles (MVs) are small lipid-based membrane-bound particles generated by virtually all cells. Here we show that RAW 264.7 macrophage cell-derived MVs can be used as vectors to deliver dexamethasone (named as MV-DEX) targeting the inflamed kidney efficiently. Methods: RAW macrophages were incubated with dexamethasone and then MV-DEX was isolated from the supernatants by centrifugation method. Nanoparticle tracking analysis, transmission electron microscopy, western blot and high-performance liquid chromatography were used to analyze the properties of MV-DEX. The LC-MS/MS was applied to investigate the protein compositions of MV-DEX. Based on the murine models of LPS- or Adriamycin (ADR)-induced nephropathy or in-vitro culture of glomerular endothelial cells, the inflammation-targeting characteristics and the therapeutic efficacy of MV-DEX was examined. Finally, we assessed the side effects of chronic glucocorticoid therapy in MV-DEX-treated mice. Results: Proteomic analysis revealed distinct integrin expression patterns on the MV-DEX surface, in which the integrin αLβ2 (LFA-1) and α4β1 (VAL-4) enabled them to adhere to the inflamed kidney. Compared to free DEX treatment, equimolar doses of MV-DEX significantly attenuated renal injury with an enhanced therapeutic efficacy against renal inflammation and fibrosis in murine models of LPS- or ADR-induced nephropathy. In vitro, MV-DEX with about one-fifth of the doses of free DEX achieved significant anti-inflammatory efficacy by inhibiting NF-κB activity. Mechanistically, MV-DEX could package and deliver glucocorticoid receptors to renal cells, thereby, increasing cellular levels of the receptor and improving cell sensitivity to glucocorticoids. Notably, delivering DEX in MVs significantly reduced the side effects of chronic glucocorticoid therapy (e.g., hyperglycemia, suppression of HPA axis). Conclusion: In summary, macrophage-derived MVs efficiently deliver DEX into the inflamed kidney and exhibit a superior capacity to suppress renal inflammation and fibrosis without apparent glucocorticoid adverse effects. Our findings demonstrate the effectiveness and security of a novel drug delivery strategy with promising clinical applications. ...
Focused Ultrasound Preconditioning for Augmented Nanoparticle Penetration and Efficacy in the Central Nervous System
Small (IF 10.856) Pub Date : 2019-10-22 ,DOI:10.1002/smll.201903460
Microbubble activation with focused ultrasound (FUS) facilitates the noninvasive and spatially‐targeteddelivery of systemically administered therapeutics across the blood–brain barrier (BBB). ...
Light-Triggered PEGylation/dePEGylation of the Nanocarriers for Enhanced Tumor Penetration
Nano Letters (IF 12.279) Pub Date : 2019-05-14 ,DOI:10.1021/acs.nanolett.9b00737
Therefore, the stimuli-responsive nanocarriers facilitated the tumor-targeted delivery of drugs through blood circulation and enhanced the antitumor effects. ...
High-Performance Worm-like Mn–Zn Ferrite Theranostic Nanoagents and the Application on Tumor Theranostics
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-06 ,DOI:10.1021/acsami.9b08948
Thus, anisotropic Mn–Zn ferrite displayed a huge potential in cancer synchronous diagnosis and treatment, that is, enhanced MRI observation was performed simultaneously when drug-targeteddelivery therapy was applied to the tumor. ...
Therapeutic effects of human monoclonal PSMA antibody-mediated TRIM24 siRNA delivery in PSMA-positive castration-resistant prostate cancer
Theranostics (IF 8.063) Pub Date : 2019-02-07 ,DOI:10.7150/thno.29884
Flow cytometry, immunofluorescence, and fluorescence imaging were performed to detect the receptor-binding, internalization, and targeted delivery of PSMAb-sulfo-SMCC-protamine (PSP)-FAM-siRNA complex (PSPS) in vitro and in vivo. ...
Surface engineering of nanomaterials with phospholipid-polyethylene glycol-derived functional conjugates for molecular imaging and targeted therapy
Biomaterials (IF 10.273) Pub Date : 2019-11-21 ,DOI:10.1016/j.biomaterials.2019.119646
Targeting moieties including small-molecule ligands, peptides, proteins, and antibodies are generally conjugated onto PEGylated phospholipids to decorate liposomes, micelles, hybrid nanoparticles, nanocomplexes, and nanoemulsions for targeted delivery of diagnostic and therapeutic agents to diseased ...
First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
Nature Communications (IF 11.878) Pub Date : 2019-09-26 ,DOI:10.1038/s41467-019-12426-9
In future, MRgFUS can be coupled with promising therapeutics providing a targeted delivery platform in ALS. ...
Avidity and Cell Uptake of Integrin-Targeting Polypeptide Micelles is Strongly Shape-Dependent
Nano Letters (IF 12.279) Pub Date : 2019-08-12 ,DOI:10.1021/acs.nanolett.9b02095
We describe a genetically encoded micelle for targeted delivery consisting of a diblock polypeptide with segments derived from repetitive protein motifs inspired by Drosophila melanogaster Rec-1 resilin and human tropoelastin with a C-terminal fusion of an integrin-targeting fibronectin type III domain ...
Dual-Blockade Immune Checkpoint for Breast Cancer Treatment Based on a Tumor-Penetrating Peptide Assembling Nanoparticle
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-18 ,DOI:10.1021/acsami.9b13354
However, the effective targeted delivery of various drugs remains a challenge. ...
Targeted Transmembrane Delivery of Ca2+ via FA-nanogel for Synergistically Enhanced Chemotherapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-16 ,DOI:10.1021/acsami.9b04967
Both in vitro and in vivo experiments confirmed that the intracellular calcium ions was continuously increased due to the targeted delivery ability and ion sustained release ability of the smart FA-nanogel, and the tumor growth was effectively inhibited by the ions synergistic chemotherapy. ...
Injectable mineralized microsphere-loaded composite hydrogels for bone repair in a sheep bone defect model
Biomaterials (IF 10.273) Pub Date : 2019-01-10 ,DOI:10.1016/j.biomaterials.2019.01.005
The efficacy of cell-based therapies as an alternative to autologous bone grafts requires biomaterials to localize cells at the defect and drive osteogenic differentiation. Hydrogels are ideal cell delivery vehicles that can provide instructional cues via their composition or mechanical properties but commonly lack osteoconductive components that nucleate mineral. To address this challenge, we entrapped mesenchymal stromal cells (MSCs) in a composite hydrogel based on two naturally-derived polymers (alginate and hyaluronate) containing biomineralized polymeric microspheres. Mechanical properties of the hydrogels were dependent upon composition. The presentation of the adhesive tripeptide Arginine-Glycine-Aspartic Acid (RGD) from both polymers induced greater osteogenic differentiation of ovine MSCs in vitro compared to gels formed of RGD-alginate or RGD-alginate/hyaluronate alone. We then evaluated the capacity of this construct to stimulate bone healing when transplanting autologous, culture-expanded MSCs into a surgical induced, critical-sized ovine iliac crest bone defect. At 12 weeks post-implantation, defects treated with MSCs transplanted in composite gels exhibited significant increases in blood vessel density, osteoid formation, and bone formation compared to acellular gels or untreated defects. These findings demonstrate the capacity of osteoconductive hydrogels to promote bone formation with autologous MSCs in a large animal bone defect model and provide a promising vehicle for cell-based therapies of bone healing. ...
A Light‐Driven Microgel Rotor
Small (IF 10.856) Pub Date : 2019-09-25 ,DOI:10.1002/smll.201903379
Tethering the ribbon to a freely rotating microsphere enables rotational motion of the spiral by stroboscopic irradiation. The efficiency of the rotor is estimated using resistive force theory for Stokes flow. ...
Direct Observation of Gas Meniscus Formation on a Superhydrophobic Surface
ACS Nano (IF 13.903) Pub Date : 2019-02-05 ,DOI:10.1021/acsnano.8b08922
Here, we report microscopic images of the formation and growth of a gas meniscus during force measurements between a superhydrophobic surface and a hydrophobic microsphere immersed in water. ...
Hybrid Protein Nano‐Reactors Enable Simultaneous Increments of Tumor Oxygenation and Iodine‐131 Delivery for Enhanced Radionuclide Therapy
Small (IF 10.856) Pub Date : 2019-10-02 ,DOI:10.1002/smll.201903628
It is hard for current radionuclide therapy to render solid tumors desirable therapeutic efficacy owing to insufficient tumor‐targeted delivery of radionuclides and severe tumor hypoxia. ...
In vivo ultrasound-activated delivery of recombinant tissue plasminogen activator from the cavity of sub-micrometric capsules
Journal of Controlled Release (IF 7.901) Pub Date : 2019-07-13 ,DOI:10.1016/j.jconrel.2019.07.017
Most of current nanomedicines suffer of very low specificity in vivo, thus rendering efficient targeteddelivery among the most wanted breakthroughs in the fields of nanotechnology and medicine. ...
Engineering multifunctional bioactive citric acid-based nanovectors for intrinsical targeted tumor imaging and specific siRNA gene delivery in vitro/in vivo.
Biomaterials (IF 10.273) Pub Date : 2019-02-08 ,DOI:10.1016/j.biomaterials.2019.01.045
Herein, we engineered a citric acid-based polymer with intrinsical photoluminescence and gene loading capacity to achieve targeted delivery of siRNA and tumor imaging in vitro and in vivo. ...
Magnetic microbubble mediated chemo-sonodynamic therapy using a combined magnetic-acoustic device
Journal of Controlled Release (IF 7.901) Pub Date : 2019-11-13 ,DOI:10.1016/j.jconrel.2019.11.013
Oxygen-loaded magnetic microbubbles have been explored as a targeted delivery vehicle for this application. Despite preliminary positive results, a previous study identified a significant practical challenge regarding the co-alignment of the magnetic and ultrasound fields. ...
Multimodal Precision Imaging of Pulmonary Nanoparticle Delivery in Mice: Dynamics of Application, Spatial Distribution, and Dosimetry
Small (IF 10.856) Pub Date : 2019-10-22 ,DOI:10.1002/smll.201904112
Targeted delivery of nanomedicine/nanoparticles (NM/NPs) to the site of disease (e.g., the tumor or lung injury) is of vital importance for improved therapeutic efficacy. Multimodal imaging platforms provide powerful tools for monitoring delivery and tissue distribution of drugs and NM/NPs. ...
Imatinib-loaded gold nanoparticles inhibit proliferation of fibroblasts and macrophages from systemic sclerosis patients and ameliorate experimental bleomycin-induced lung fibrosis
Journal of Controlled Release (IF 7.901) Pub Date : 2019-08-17 ,DOI:10.1016/j.jconrel.2019.08.015
Specifically, engineered gold nanoparticles (GNPs) are proposed as targeted delivery system increasing efficacy of drugs with antifibrotic effect, such as tyrosine kinases. ...
Water-Soluble Phthalocyanines Selectively Bind to Albumin Dimers: A Green Approach Toward Enhancing Tumor-Targeted Photodynamic Therapy
Theranostics (IF 8.063) Pub Date : 2019-08-14 ,DOI:10.7150/thno.35210
Targeted delivery of therapeutic agents is of particular interest in the field of cancer treatment. However, there is an urgent need for developing clinically promising targeting approaches that can be readily administered in a green manner. ...
Graphene Quantum Dots in the Game of Directing Polymer Self-Assembly to Exotic Kagome Lattice and Janus Nanostructures
ACS Nano (IF 13.903) Pub Date : 2019-08-07 ,DOI:10.1021/acsnano.9b04188
Herein, with the help of a suite of characterizations, we delineate the mechanism behind the formation of the KL and JNMs which forms a depot of heightened drug accretion with targeted delivery of 5-fluorouracil in the colon as validated by gamma scintigraphy studies. ...
Direct Nucleus‐Targeted Drug Delivery Using Cascade pHe/Photo Dual‐Sensitive Polymeric Nanocarrier for Cancer Therapy
Small (IF 10.856) Pub Date : 2019-07-18 ,DOI:10.1002/smll.201902022
The cell nucleus‐targeted delivery of therapeutic agents plays a critical role in cancer therapy, since the biological target of many anticancer therapeutics is the cell nucleus. ...
Synergistic Energy Nanoconfinement and Water Activation in Hydrogels for Efficient Solar Water Desalination
ACS Nano (IF 13.903) Pub Date : 2019-07-02 ,DOI:10.1021/acsnano.9b02301
Light-absorbing hydrogels provide a means for evaporating water by using solar energy, yet targeteddelivery of solar thermal energy to power the water evaporation process remains challenging. ...
Nose-to-brain delivery of hyaluronate – FG loop peptide conjugate for Non-invasive hypoxic-ischemic encephalopathy therapy
Journal of Controlled Release (IF 7.901) Pub Date : 2019-06-20 ,DOI:10.1016/j.jconrel.2019.06.021
The intranasal drug administration has attracted great interest as a non-invasive route allowing targeteddelivery of drugs directly to the brain. However, one of the main issues in nasal drug administration is mucociliary clearance. ...
Advanced Lithium Metal–Carbon Nanotube Composite Anode for High-Performance Lithium–Oxygen Batteries
Nano Letters (IF 12.279) Pub Date : 2019-08-08 ,DOI:10.1021/acs.nanolett.9b02560
Herein, we report a lithium metal–carbon nanotube (Li–CNT) composite as an alternative to the long-term untamed lithium electrode to address the critical issues associated with the lithium anode in Li–O2 batteries, where the lithium metal is impregnated in a porous carbon nanotube microsphere matrix ...
EcoFlex Sponge with Ultrahigh Oil Absorption Capacity
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-22 ,DOI:10.1021/acsami.9b04446
A paraffin microsphere-templated 3D porous EcoFlex sponge was prepared to selectively absorb oil or chemicals from water. The technology for producing this EcoFlex sponge does not need complicated synthesis processes or instruments, and the materials applied in this work are ecofriendly. ...
Monodisperse Carbon Sphere-Constructed Pomegranate-Like Structures for High-Volumetric-Capacitance Supercapacitors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-15 ,DOI:10.1021/acsami.8b19901
Herein, we propose a pomegranate-like carbon microsphere (PCS) constructed by monodisperse, submicron, N-doped microporous carbon spheres for high-volumetric-capacitance supercapacitors. ...
Targeting downstream subcellular YAP activity as a function of matrix stiffness with Verteporfin-encapsulated chitosan microsphere attenuates osteoarthritis
Biomaterials (IF 10.273) Pub Date : 2019-12-26 ,DOI:10.1016/j.biomaterials.2019.119724
Changes in the stiffness of chondrocyte extracellular matrix (ECM) are involved in the pathological progression of osteoarthritis (OA). However, the downstream responses of cartilage ECM stiffness are still unclear. YAP (Yes-associated protein) has been extensively studied as a mechanotransducer, we thus hypothesized that by targeting the downstream molecule activity of ECM stiffness could maintain chondrocyte phenotype and prevent cartilage degeneration in OA. Here, we showed that human cartilage matrix stiffened during pathological progression of OA, and the chondrocyte YAP activity was associated with ECM stiffness. We then mimicked the physiological and pathological stiffness of human cartilage by using PDMS-based substrates, and found that YAP was activated in chondrocytes seeded on stiff substrate, gradually losing their phenotype. In addition, it was observed that YAP was also significantly activated in mice OA development, and conditional knockout (cKO) of YAP in mice preserved collagen II expression and protected cartilage from degeneration in the OA model. Furthermore, intra-articular injection of YAP-selective inhibitor, Verteporfin, significantly maintained cartilage homeostasis in mice OA model. This study indicates that the application of mechanotransducer-targeted drugs could be a potential therapeutic approach for cartilage repair in OA. ...
Calligraphy/Painting Based on a Bioinspired Light-Driven Micromotor with Concentration-Dependent Motion Direction Reversal and Dynamic Swarming Behavior
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-16 ,DOI:10.1021/acsami.9b14402
In this paper, we demonstrate a novel near-infrared (NIR) light-powered micromotor consisting of a polystyrene microsphere and a polydopamine core–shell structure (PS@PDA) with concentration-dependent motion direction reversal and dynamic swarming behavior. ...
Cuboidal tethered cyclodextrin frameworks tailored for hemostasis and injured vessel targeting.
Theranostics (IF 8.063) Pub Date : 2019-05-28 ,DOI:10.7150/thno.31159
Rationale: Targeted delivery of therapeutic drugs or imaging agents to injured blood vessels via nanocarriers is likely to be dependent on the particle shape, yet cubic nanoparticle carriers have not been reported for vascular targeting. ...
Current strategies for different paclitaxel-loaded Nano-delivery Systems towards therapeutic applications for ovarian carcinoma: A review article
Journal of Controlled Release (IF 7.901) Pub Date : 2019-08-30 ,DOI:10.1016/j.jconrel.2019.08.034
Moreover, challenges in physicochemical properties, biological activity and targeted delivery of PTX were depicted with corresponding solutions using nanotechnology. ...
Local Immunomodulation Using an Adhesive Hydrogel Loaded with miRNA‐Laden Nanoparticles Promotes Wound Healing
Small (IF 10.856) Pub Date : 2019-07-22 ,DOI:10.1002/smll.201902232
However, local‐targeted delivery of microRNAs is still challenging, due to their low stability. Here, adhesive hydrogels containing miR‐223 5p mimic (miR‐223*) loaded hyaluronic acid nanoparticles are developed to control tissue macrophages polarization during wound healing processes. ...
Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy
Biomaterials (IF 10.273) Pub Date : 2019-05-31 ,DOI:10.1016/j.biomaterials.2019.119232
In this study, biocompatible multifunctional lipid-coated calcium phosphate nanoparticles (LCP NPs) were designed and constructed as an efficient targeted delivery system for combined gene/photothermal therapy to inhibit growth of the triple negative breast tumor (MDA-MB-468) in vitro and in vivo. ...
Chimeric peptide engineered exosomes for dual-stage light guided plasma membrane and nucleus targeted photodynamic therapy
Biomaterials (IF 10.273) Pub Date : 2019-05-04 ,DOI:10.1016/j.biomaterials.2019.05.004
Targeted delivery of the drug to its therapeutically active site with low immunogenicity and system toxicity is critical for optimal tumor therapy. ...
Terminal Deoxynucleotidyl Transferase-Catalyzed Preparation of pH-Responsive DNA Nanocarriers for Tumor-Targeted Drug Delivery and Therapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-15 ,DOI:10.1021/acsami.9b05358
Developing a highly efficient carrier for tumor-targeted delivery and site-specific release of anticancer drugs is a good way to overcome the side effects of traditional cancer chemotherapy. ...
Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis
Nano Letters (IF 12.279) Pub Date : 2019-04-19 ,DOI:10.1021/acs.nanolett.8b05202
In this study, the efficacy, specificity, and safety of P-selectin targeted delivery and microwave (MW) responsive drug release is investigated for development of HCC therapy. ...
Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters
Biomaterials (IF 10.273) Pub Date : 2019-03-20 ,DOI:10.1016/j.biomaterials.2019.03.021
Here, we develop polymeric perfluorocarbon nanoemulsions into a generalized platform for ultrasound-targeted delivery of hydrophobic drugs with high potential for clinical translation. ...
Tunable Nanoscale Cages from Self-Assembling DNA and Protein Building Blocks
ACS Nano (IF 13.903) Pub Date : 2019-03-12 ,DOI:10.1021/acsnano.8b09798
Our approach will allow for the construction of nanomaterials that possess the advantages of both protein and DNA nanotechnology and find applications in fields such as targeted delivery, structural biology, biomedicine, and catalytic materials. ...
Highly Thermally Conductive Polymer Composite Originated from Assembly of Boron Nitride at an Oil–Water Interface
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-31 ,DOI:10.1021/acsami.9b15259
Composite substrates were fabricated through hot-compressing the PS@BN microspheres to form BN networks based on the original microsphere template. ...
Mitochondria-Responsive Drug Release along with Heat Shock Mediated by Multifunctional Glycolipid Micelles for Precise Cancer Chemo-Phototherapy.
Theranostics (IF 8.063) Pub Date : 2019-02-28 ,DOI:10.7150/thno.31022
Methods: This strategy relies on mitochondrial-targeted delivery of doxorubicin (DOX) through a photothermal and lipophilic agent IR-780 iodide (IR780)-modified glycolipid conjugates (CSOSA), which can synergistically triggers high-level reactive oxygen species (ROS) to kill tumor cells. ...
Synergistic effect of all-trans-retinal and triptolide encapsulated in an inflammation-targeted nanoparticle on collagen-induced arthritis in mice
Journal of Controlled Release (IF 7.901) Pub Date : 2019-12-18 ,DOI:10.1016/j.jconrel.2019.12.025
Targeted delivery of nano-encapsulated anti-inflammatory agent represents a promising while challenging strategy in the treatment of rheumatoid arthritis (RA). Pro-inflammatory macrophages play a major role in the pathogenesis of RA. ...
Target engagement and intracellular delivery of mono- and bivalent LDL receptor-binding peptide-cargo conjugates: implications for the rational design of new targeted drug therapies
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-20 ,DOI:10.1016/j.jconrel.2019.10.033
Targeted delivery to specific tissues and subcellular compartments is of paramount importance to optimize therapeutic or diagnostic interventions while minimizing side-effects. ...
Synergistic Chemotherapy and Photodynamic Therapy of Endophthalmitis Mediated by Zeolitic Imidazolate Framework‐Based Drug Delivery Systems
Small (IF 10.856) Pub Date : 2019-10-07 ,DOI:10.1002/smll.201903880
Herein, aiming at efficient photodynamic therapy (PDT) of bacterial infections and biofilm eradication of endophthalmitis, a pH‐responsive zeolitic imidazolate framework‐8‐polyacrylic acid (ZIF‐8‐PAA) material is constructed for bacterial infection–targeted delivery of ammonium methylbenzene blue (MB ...
Sequentially Site-Specific Delivery of Thrombolytics and Neuroprotectant for Enhanced Treatment of Ischemic Stroke
ACS Nano (IF 13.903) Pub Date : 2019-07-24 ,DOI:10.1021/acsnano.9b01798
A sequentially targeted delivery system is highly desired to deliver thrombolytics and neuroprotectant to the site of the thrombus and ischemic penumbra, respectively, to pursue a maximized combinational effect. ...
Platelets as platforms for inhibition of tumor recurrence post-physical therapy by delivery of anti-PD-L1 checkpoint antibody
Journal of Controlled Release (IF 7.901) Pub Date : 2019-05-06 ,DOI:10.1016/j.jconrel.2019.05.008
Moreover, this platelet-based delivery strategy may be extended to the targeted delivery of therapeutics post other types of local therapies including photodynamic therapy, high-intensity-focused-ultrasound ablation therapy, and even radiotherapy. ...
Ulcerative colitis-specific delivery of keratinocyte growth factor by neutrophils-simulated liposomes facilitates the morphologic and functional recovery of the damaged colon through alleviating the inflammation
Journal of Controlled Release (IF 7.901) Pub Date : 2019-02-23 ,DOI:10.1016/j.jconrel.2019.02.034
Overall, the neutrophil-like liposome may be an excellent carrier for the colitis-targeted delivery of KGF. ...
From Structure to Function: pH-Switchable Antimicrobial Nano-Self-Assemblies
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-11 ,DOI:10.1021/acsami.8b18618
Stimuli-responsive nanocarriers based on lipid self-assemblies have the potential to provide targeteddelivery of antimicrobial peptides, limiting their side effects while protecting them from degradation in the biological environments. ...
Mesenchymal Stem Cell Capping on ECM‐Anchored Caspase Inhibitor–Loaded PLGA Microspheres for Intraperitoneal Injection in DSS‐Induced Murine Colitis
Small (IF 10.856) Pub Date : 2019-04-24 ,DOI:10.1002/smll.201901269
Intraperitoneal injection of the MSC–microsphere hybrid alleviates experimental colitis in a murine model via inhibiting Th1 and Th17 differentiation of CD4+ T cells in colon‐draining mesenteric lymph nodes. ...
Photochemically Excited, Pulsating Janus Colloidal Motors of Tunable Dynamics
ACS Nano (IF 13.903) Pub Date : 2019-04-01 ,DOI:10.1021/acsnano.8b08276
Inspired by previous studies of oscillating silver microparticles, we report silver–poly(methyl methacrylate) microsphere Janus colloidal motors that moved, interacted with tracers, and exhibited negative gravitaxis all in an oscillatory fashion. ...
NixMnyCozO Nanowire/CNT Composite Microspheres with 3D Interconnected Conductive Network Structure via Spray‐Drying Method: A High‐Capacity and Long‐Cycle‐Life Anode Material for Lithium‐Ion Batteries
Small (IF 10.856) Pub Date : 2019-03-12 ,DOI:10.1002/smll.201900069
Additionally, the empty spaces among the nanowires in the network accommodate microsphere volume expansion associated with Li+ intercalation during the cycling process, which improves the cycling stability of the electrode. ...
Targeted delivery of hesperetin to cartilage attenuates osteoarthritis by bimodal imaging with Gd2(CO3)3@PDA nanoparticles via TLR-2/NF-κB/Akt signaling
Biomaterials (IF 10.273) Pub Date : 2019-03-18 ,DOI:10.1016/j.biomaterials.2019.03.018
The progressive degeneration of cartilage marks the advancement of osteoarthritis (OA), which requires specific targeted treatment for effective cartilage repair. However, there is still no efficient cartilage delivery system or novel magnetic resonance (MR) contrast agent (CA). Herein, we report the synthesis of a novel class of MR CA, Gd2(CO3)3-based nanoparticles (NPs), from a simpler and “greener” approach than previous ones. After the coating of polydopamine (PDA) onto the Gd2(CO3)3 core, we further anchored a cartilage-targeting peptide and loaded hesperetin (Hes) into NPs (Hes-Gd2(CO3)3@PDA-PEG-DWpeptide, HGdPDW), showing excellent cartilage affinity and MR suitability. Additionally, the synthesized HGdPDW exerted significant protective effects against IL-1β stimulation, as shown by the decreased apoptosis and inflammation and increased maturation of chondrocytes in vitro. More importantly, RNA-seq analyses showed the significant reduction of TLR-2 in IL-1β-treated chondrocytes, and this reduction was followed by the inactivation of NF-κB/Akt signaling, leading to the protective effect of HGdPDW. By the establishment of anterior cruciate ligament transection (ACLT) OA mice, the bimodal MRI/IVIS imaging demonstrated the effective cartilage-binding ability of HGdPDW in OA knees with low cytotoxicity, which alleviated the gradual degeneration of articular cartilage in vivo by inhibiting TLR-2 in chondrocytes. Taken together, these results suggest that HGdPDW could target cartilage effectively, thereby protecting chondrocytes from apoptosis and inflammation via TLR-2/NF-κB/Akt signaling. We hope this new class of MRI CA could be applied in not only other fields using MRI technology but also the treatment of general cartilage-related diseases; this application will undoubtedly extend the treatment of OA clinically. ...
Pt/NiO Microsphere Composite as Efficient Multifunctional Catalysts for Nonaqueous Lithium–Oxygen Batteries and Alkaline Fuel Cells: The Synergistic Effect of Pt and Ni
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-18 ,DOI:10.1021/acsami.9b11623
Developing efficient and low-cost multifunctional electrocatalysts is important for electrochemical devices. In this work, a cost-effective Pt/NiO composite with very limited Pt loading (from 0.5 to 3%) was controllably synthesized through facile hydrothermal procedures. The composite demonstrated the improved catalytic performance as applied to the nonaqueous Li–O2 batteries and the alkaline fuel cells. Regarding the alkaline fuel cells, 1% Pt/NiO composite gave rise to the best Pt distribution and thus exhibited the optimized electrochemical conductivity and properties as suggested by the significantly improved electrochemical reversibility. Meanwhile, the demonstrated 1% Pt/NiO composite presented high catalytic capability as electrode for Li–O2 batteries, which allowed for much improved capacity utilization, high cycling stability, high initial capacity (2329 mAh/g), and no obvious voltage drop during cycling. Such multiple advantages of prepared composite electrode material offer new prospects and application as multifunctional electrocatalysts for both Li–O2 batteries and alkaline fuel cells. ...
Application of Virus Targeting Nanocarrier Drug Delivery System in Virus-Induced Central Nervous System Disease Treatment
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-16 ,DOI:10.1021/acsami.9b06365
The targeted delivery system based on MWCNTs conjugated with polyethylenimine, ribavirin, and PGNNV-specific nanobody was constructed and designated as MWCNTs-PEI-R-Nb. Targeting ability and treatment effects of the MWCNTs-PEI-R-Nb were checked both in vitro and in vivo. ...
Ultrasound Facilitates Naturally Equipped Exosomes Derived from Macrophages and Blood Serum for Orthotopic Glioma Treatment
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-15 ,DOI:10.1021/acsami.9b00893
In this study, we developed a natural and safe transportation system using FUS to increase the targeteddelivery of Exos for glioma therapy. ...
Capillary-Flow-Optimized Heat Localization Induced by an Air-Enclosed Three-Dimensional Hierarchical Network for Elevated Solar Evaporation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-27 ,DOI:10.1021/acsami.8b21800
This prediction is confirmed through using a bilayered solar steam generation architecture [hollow glass microsphere–carbon black (HS–CB)] both in laboratory- and pilot-scale studies. ...
Bacterial Biofilm Bioinspired Persistent Luminescence Nanoparticles with Gut-Oriented Drug Delivery for Colorectal Cancer Imaging and Chemotherapy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-26 ,DOI:10.1021/acsami.9b12853
To sum up, this LRM bioinspired nanoparticles could tolerate the digestion of gastric acid, avoid aggregation by the immune system, favor gut-oriented drug delivery, and targeted release oral 5-FU into colorectum for more than 24 h, which may give new application prospects for targeted delivery of oral ...
Photothermal therapy mediated by phase-transformation nanoparticles facilitates delivery of anti-PD1 antibody and synergizes with antitumor immunotherapy for melanoma
Journal of Controlled Release (IF 7.901) Pub Date : 2019-05-25 ,DOI:10.1016/j.jconrel.2019.05.036
In conclusion, [email protected] NPs combined with PTT could potentiate the efficacy of aPD1 not only by tumor-targeted delivery of aPD1 but also by activating the immune system in the tumor microenvironment, which is a highly effective approach to treat melanoma. ...
Targeted Interleukin-22 Gene Delivery in the Liver by Polymetformin and Penetratin-Based Hybrid Nanoparticles to Treat Nonalcoholic Fatty Liver Disease
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-25 ,DOI:10.1021/acsami.8b19717
This liver-targeted delivery of IL-22 activated STAT3/Erk1/2 and Nrf2/SOD1 signaling transductions as well as modulated lipid-metabolism-related gene expression. ...
Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells
Journal of Controlled Release (IF 7.901) Pub Date : 2019-01-09 ,DOI:10.1016/j.jconrel.2019.01.006
Here we report a glucose-installed sub-50-nm nanocarrier for the targeted delivery of small interfering RNA (siRNA) to CSCs through selective recognition of the glucose ligand to the glucose transporter 1 (GLUT1) overexpressed on the CSC surface. ...
Dual ATP and pH responsive ZIF-90 nanosystem with favorable biocompatibility and facile post-modification improves therapeutic outcomes of triple negative breast cancer in vivo
Biomaterials (IF 10.273) Pub Date : 2019-01-04 ,DOI:10.1016/j.biomaterials.2019.01.001
Combining targeted delivery and dual responsive release of DOX significantly improves the therapeutic efficacy of AP-ZIF-90@DOX in MDA-MB-231 tumor bearing mouse, and results in 80% survival rate over 40 days of treatment. ...
Glutathione-Functionalized Magnetic Covalent Organic Framework Microspheres with Size Exclusion for Endogenous Glycopeptide Recognition in Human Saliva
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-04 ,DOI:10.1021/acsami.9b15905
Reported here is a novel glutathione-functionalized magnetic covalent organic framework microsphere(denoted as MCNC@COF@GSH) endowed with size-exclusion effect and strong hydrophilicity for selective and efficient enrichment of N-linked glycopeptides. ...
Realizing the Control of Electronic Energy Level Structure and Gas-Sensing Selectivity over Heteroatom-Doped In2O3 Spheres with an Inverse Opal Microstructure
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-19 ,DOI:10.1021/acsami.8b21543
Accordingly, the IO-(Ga0.2In0.8)2O3 microsphere sensor showed a high response toward formaldehyde with fast response and recovery speeds, and ultralow detection limit (50 ppb). ...
Rational Design of Robust Si/C Microspheres for High-Tap-Density Anode Materials
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-15 ,DOI:10.1021/acsami.8b20213
Furthermore, the full cell assembled with LiNi0.8Co0.1Mn0.1O2 and the resultant Si/C microsphere anode also displays good cycling performance and rate capabilities. ...
Corrigendum to "Long-acting hydrogel/microsphere composite sequentially releases dexmedetomidine and bupivacaine for prolonged synergistic analgesia" [Biomaterials 181 (2018) 378-391].
Biomaterials (IF 10.273) Pub Date : 2019-05-28 ,DOI:10.1016/j.biomaterials.2019.05.016


Systemic delivery of microRNA-21 antisense oligonucleotides to the brain using T7-peptide decorated exosomes
Journal of Controlled Release (IF 7.901) Pub Date : 2019-11-12 ,DOI:10.1016/j.jconrel.2019.11.009
However, glioblastoma-targeted delivery through systemic injection requires development of an efficient targeting carrier. For this purpose, a glioblastoma-targeting carrier was developed using the T7 peptide and exosomes. ...
Magnetic Semiconductor Gd-Doping CuS Nanoparticles as Activatable Nanoprobes for Bimodal Imaging and Targeted Photothermal Therapy of Gastric Tumors
Nano Letters (IF 12.279) Pub Date : 2019-01-30 ,DOI:10.1021/acs.nanolett.8b04179
Targeted delivery of enzyme-activatable probes into cancer cells to facilitate accurate imaging and on-demand photothermal therapy (PTT) of cancers with high spatiotemporal precision promises to advance cancer diagnosis and therapy. ...
Chemically Bonding NiFe-LDH Nanosheets on rGO for Superior Lithium-Ion Capacitors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-20 ,DOI:10.1021/acsami.9b10719
The corresponding lithium-ion capacitor with NiFe-LDH/rGO anode and mesoporous carbon microspherecathode exhibits high energy density and power density simultaneously, with 133 Wh kg–1 at 25 W kg–1 and 4016 W kg–1 at 58 Wh kg–1, showing the great potential for high-performance hybrid energy storage ...
Enhancing High-Voltage Performance of Ni-Rich Cathode by Surface Modification of Self-Assembled NASICON Fast Ionic Conductor LiZr2(PO4)3
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-22 ,DOI:10.1021/acsami.9b00389
With well-designed architecture and a uniform NASICON-type LZP nanolayer wrapping over the NCA microsphere, the entire electrode demonstrates exceptional Li+ diffusion and conductivity and suppresses the side reaction between electrolyte and electroactive NCA, stabilizing the phase interface with less ...
Microfluidics Assisted Fabrication of Three-Tier Hierarchical Microparticles for Constructing Bioinspired Surfaces
ACS Nano (IF 13.903) Pub Date : 2019-03-15 ,DOI:10.1021/acsnano.9b00245
Such a hierarchical microsphere mimics individual units of bioinspired surfaces. ...
A Simple and Scalable Route to Synthesize CoxCu1−xCo2O4@CoyCu1−yCo2O4 Yolk–Shell Microspheres, A High‐Performance Catalyst to Hydrolyze Ammonia Borane for Hydrogen Production
Small (IF 10.856) Pub Date : 2019-02-04 ,DOI:10.1002/smll.201805460
These yolk–shell structured CoxCu1−xCo2O4@CoyCu1−yCo2O4 microsphere is a promising catalyst candidate in AB hydrolysis considering the excellent catalytic behavior and low cost. ...
Indium-111 labelling of liposomal HEGF for radionuclide delivery via ultrasound-induced cavitation
Journal of Controlled Release (IF 7.901) Pub Date : 2019-12-28 ,DOI:10.1016/j.jconrel.2019.12.045
By combining acoustic-cavitation-sensitive liposomes with radiopharmaceuticals this research represents a new concept in achieving targeted delivery of radiopharmaceuticals. ...
Non-immunogenic, low-toxicity and effective glioma targeting MTI-31 liposomes
Journal of Controlled Release (IF 7.901) Pub Date : 2019-11-12 ,DOI:10.1016/j.jconrel.2019.11.005
Liposomes with peptide motifs have been successfully used in glioma-targeted delivery of various general chemotherapy agents. However, their use for the encapsulation of low-toxicity molecularly targeted anticancer agents has been limited. ...
In vitro-in vivo correlation of parenteral PLGA microspheres: Effect of variable burst release
Journal of Controlled Release (IF 7.901) Pub Date : 2019-10-22 ,DOI:10.1016/j.jconrel.2019.10.014
present work were: 1) to investigate the predictability of developed IVIVCs for the in vivo burst release phase based on the in vitro burst release phase of the formulations; and 2) to evaluate the impact of variable burst release on the predictability of the developed IVIVCs for two different types of microsphere-based ...
Highly Polyvalent DNA Motors Generate 100+ pN of Force via Autochemophoresis
Nano Letters (IF 12.279) Pub Date : 2019-09-09 ,DOI:10.1021/acs.nanolett.9b02311
In this work, we demonstrate that highly polyvalent DNA motors (HPDMs), which can be viewed as cooperative teams of thousands of DNA walkers attached to a microsphere, can generate and sustain substantial forces in the 100+ pN regime. ...
CNT-Decorated Na4Mn2Co(PO4)2P2O7 Microspheres as a Novel High-Voltage Cathode Material for Sodium-Ion Batteries
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-22 ,DOI:10.1021/acsami.9b07595
The well-designed Na4Mn2Co(PO4)2P2O7/C-CNTs microsphere has excellent electronic and ionic conductivity by virtue of the carbon nanotube conductive skeleton. ...
The antifibrotic potential of a sustained release formulation of a PDGFβ-receptor targeted rho kinase inhibitor
Journal of Controlled Release (IF 7.901) Pub Date : 2019-01-22 ,DOI:10.1016/j.jconrel.2018.12.039
A single subcutaneous microsphere administration followed by organ harvest one week later clearly attenuated liver fibrosis progression and significantly suppressed the expression of fibrosis related genes, such as several collagens, profibrotic cytokines and matrix metalloproteinases. ...
Intranasal delivery of targeted polyfunctional gold–iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide
Biomaterials (IF 10.273) Pub Date : 2019-07-12 ,DOI:10.1016/j.biomaterials.2019.119342
To address this, we explore the potential of the nose-to-brain direct transport pathway to bypass the blood-brain barrier, and to enable targeted delivery of theranostic polyfunctional gold-iron oxide nanoparticles (polyGIONs) surface loaded with therapeutic miRNAs (miR-100 and antimiR-21) to GBMs in ...
Dual-responsive, Methotrexate-loaded, Ascorbic acid-derived Micelles Exert Anti-tumor and Anti-metastatic Effects by Inhibiting NF-κB Signaling in an Orthotopic Mouse Model of Human Choriocarcinoma
Theranostics (IF 8.063) Pub Date : 2019-06-09 ,DOI:10.7150/thno.35125
Conclusions: Our results highlight the potential of PEG-ss-aAPP micelles for targeted delivery of chemotherapeutic agents against choriocarcinoma. Keywords: Orthotopic choriocarcinoma, Ascorbyl phosphate palmitate derivative, Methotrexate, Dual-responsive micelles, NF-κB signaling pathway ...
Enhanced Therapeutic Effect of RGD-Modified Polymeric Micelles Loaded With Low-Dose Methotrexate and Nimesulide on Rheumatoid Arthritis.
Theranostics (IF 8.063) Pub Date : 2019-02-28 ,DOI:10.7150/thno.30418
Conclusion: Our results confirmed that the targeted delivery of the combination of a low dose of methotrexate and nimesulide mediated by RGD-modified polymeric micelles could enhance the therapeutic effect on rheumatoid arthritis. ...
Extracellular vesicles expressing a single-chain variable fragment of an HIV-1 specific antibody selectively target Env+ tissues
Theranostics (IF 8.063) Pub Date : 2019-07-29 ,DOI:10.7150/thno.33925
Keywords: HIV-targeted delivery system, exosome, extracellular vesicles, chemotherapy, RNAi-therapy ...
A Novel Antifungal Plasma-Activated Hydrogel
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-22 ,DOI:10.1021/acsami.9b04700
In this study, we proposed and designed an alternative antifungal hydrogel preparation strategy to obtain hydrogels with high antifungal abilities. We employed plasma-activated water (PAW) instead of water in the hydrogel polymerization process to prepare plasma-activated hydrogels (PAHs). ...
Controlling the Surface Chemistry of a Hydrogel for Spatially Defined Cell Adhesion
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-16 ,DOI:10.1021/acsami.9b04023
The first step exploits the water content of the hydrogel and the hydrophobicity of the reaction solvent to create a thin oxide layer on the hydrogel surface using a common titanium or zirconium alkoxide. ...
Biocompatible Injectable Magnetic Hydrogel Formed by Dynamic Coordination Network
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-26 ,DOI:10.1021/acsami.9b17627
Magnetic hydrogel that can respond to a magnetic stimulus is a promising biomaterial for tissue regeneration and cancer treatment. ...
Drawing High-Definition and Reversible Hydrogel Paintings with Grayscale Exposure
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-31 ,DOI:10.1021/acsami.9b14342
The resultant grayscale hydrogel patterns, with visible light transmittance adjustable, are reversible during hydration (in 1–2 s) and dehydration and possess the feature size of 70 μm and more pattern information compared with previous hydrogel patterning. ...
Self-Healing and Highly Stretchable Gelatin Hydrogel for Self-Powered Strain Sensor
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-19 ,DOI:10.1021/acsami.9b18646
The hydrogel also has a rapid self-healing ability (within 0.65 s) and high self-healing efficiency (95%). The hydrogel operates as an efficient electrolyte material and forms a hydrogel battery when assembled with a thin layer of zinc and an air electrode. ...
Bioprinting of a Cell-Laden Conductive Hydrogel Composite
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-16 ,DOI:10.1021/acsami.9b07353
The synergy of an advanced fabrication method and conductive hydrogel presented here is promising for engineering complex conductive and cell-laden structures. ...
Skin-Inspired Surface-Microstructured Tough Hydrogel Electrolytes for Stretchable Supercapacitors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-07 ,DOI:10.1021/acsami.9b03410
Through investigating the properties of the tough hydrogel electrolyte and the electrochemical performance of the as-fabricated supercapacitors under varied strains, the surface-microstructured hydrogel electrolyte was shown to enable robust adhesion to electrodes, improving electrochemical behavior ...
Mechanoresponsive Hydrogel Particles as a Platform for Three-Dimensional Force Sensing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-12 ,DOI:10.1021/acsami.9b04312
The hydrogel particles with controlled polymer network are produced via droplet microfluidics from poly(ethylene glycol) (PEG) precursors. Förster resonance energy transfer donors and acceptors are coupled to the PEG hydrogel network for reporting local deformations as fluorescence shifts. ...
Noncovalent Muscle-Inspired Hydrogel with Rapid Recovery and Antifatigue Property under Cyclic Stress
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-14 ,DOI:10.1021/acsami.9b10753
Furthermore, the hydrogel was found to be self-healed. This hydrogel promises to be among the most relevant drivers for the development of new-generation muscle-inspired hydrogels in the next decade. ...
2.5D Hierarchical Structuring of Nanocomposite Hydrogel Films Containing Cellulose Nanocrystals
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-30 ,DOI:10.1021/acsami.8b16232
Although two-dimensional hydrogel thin films have been applied across many biomedical applications, creating higher dimensionality structured hydrogel interfaces would enable potentially improved and more biomimetic hydrogel performance in biosensing, bioseparations, tissue engineering, drug delivery ...
Construction of Biofunctionalized Anisotropic Hydrogel Micropatterns and Their Effect on Schwann Cell Behavior in Peripheral Nerve Regeneration
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-02 ,DOI:10.1021/acsami.9b08510
The morphology, swelling ratio, wettability, mechanical properties, and stability of the prepared hydrogelwere characterized. The successful immobilization of YIGSR peptide on the PAM hydrogel was monitored using FTIR, immunofluorescence staining, and ELISA. ...
Programming the Shape Transformation of a Composite Hydrogel Sheet via Erasable and Rewritable Nanoparticle Patterns
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-04 ,DOI:10.1021/acsami.9b16610
The present strategy is simple, fast, and efficient in reprogramming the shape change of the thermoresponsive hydrogel material. The composite hydrogel sheet may find applications in soft robotics, tissue engineering, and controlled release. ...
Microplasma Cross-Linked Graphene Oxide-Gelatin Hydrogel for Cartilage Reconstructive Surgery
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-19 ,DOI:10.1021/acsami.9b14073
Highly energetic reactive radicals were generated from the nonthermal plasma (NTP), which is used to facilitate the cross-linking and polymerization during the polymeric hydrogel fabrication. The NTP treatment substantially reinforced a small amount (1 wt %) of NGO into the gelatin hydrogel. ...
Photodirected Morphing Structures of Nanocomposite Shape Memory Hydrogel with High Stiffness and Toughness
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-11 ,DOI:10.1021/acsami.9b16894
Here we report a stiff and tough shape memory hydrogel that can transform to various configurations sequentially by phototriggered site-specific deformations. ...
Enabling Free-Standing 3D Hydrogel Microstructures with Microreactive Inkjet Printing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-24 ,DOI:10.1021/acsami.9b17192
For inkjet printing of hydrogel structures, a hydrogel precursor (or cross-linker) is printed onto a cross-linker (or precursor) bath or a substrate. ...
First Aldol Cross-Linked Hyaluronic Acid Hydrogel: Fast and Hydrolytically Stable Hydrogel with Tissue Adhesive Properties
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-04 ,DOI:10.1021/acsami.9b10239
Finally, we demonstrate that the novel hydrogel is biocompatible with encapsulated stem cells that show a linear rate of expansion in our 3–6 days of study. ...
Fingerprintable Hydrogel from Dual Reversible Cross-Linking Networks with Different Relaxation Times
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-02 ,DOI:10.1021/acsami.9b06754
Such a hydrogel with viscoelastic property cannot be remolded under mild conditions. Here, we demonstrated that a combination of dual reversible cross-linking with different relaxation time scales could be used to develop a remoldable hydrogel responding to mild external stress. ...
Polyvinyl Alcohol/Silk Fibroin/Borax Hydrogel Ionotronics: A Highly Stretchable, Self-Healable, and Biocompatible Sensing Platform
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-19 ,DOI:10.1021/acsami.9b06920
In this ionic hydrogel, polyvinyl alcohol and borax offer the high stretchability and conductivity, respectively, while silk fibroin improves the stability of the hydrogel and increases water uptake by the gels. ...
Reversibly Assembled Electroconductive Hydrogel via a Host–Guest Interaction for 3D Cell Culture
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-15 ,DOI:10.1021/acsami.8b19482
Myoblast C2C12 cells were encapsulated in the conductive hydrogel and exhibited proliferation rate comparable to that in nonconductive S-Alg-Ad/Pβ-CD hydrogel. The cells could be released from the hydrogels by adding the β-CD monomer. ...
Ultrastiff, Tough, and Healable Ionic–Hydrogen Bond Cross-Linked Hydrogels and Their Uses as Building Blocks To Construct Complex Hydrogel Structures
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-23 ,DOI:10.1021/acsami.8b20520
Various complex hydrogel structures can be constructed by using the P(AM-co-AA)/Na-alginate/Fe3+ hydrogels as building blocks via the adhesion of as-prepared hydrogels. ...
In Situ Fabrication of Intelligent Photothermal Indocyanine Green–Alginate Hydrogel for Localized Tumor Ablation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-08 ,DOI:10.1021/acsami.8b16517
The in situ-fabricated ICG–alginate hydrogel was applied successfully in highly efficient PTT in vivo without obvious side effects. ...
Highly Stretchable, Adhesive, and Mechanical Zwitterionic Nanocomposite Hydrogel Biomimetic Skin
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-17 ,DOI:10.1021/acsami.9b14040
A plant-inspired zwitterionic hydrogel was prepared through rapid UV initiation in the existence of cellulose nanocrystals as physically crosslinker and reinforcing agent. ...
Investigations of Anti-Inflammatory Activity of a Peptide-Based Hydrogel Using Rat Air Pouch Model
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-10 ,DOI:10.1021/acsami.8b19228
The hydrogel showed an antibacterial efficacy against Gram-positive and Gram-negative bacteria. In vivo anti-inflammatory activity of the hydrogel was investigated using the rat air pouch model of acute inflammation. ...
Multifunctional Glycerol–Water Hydrogel for Biomimetic Human Skin with Resistance Memory Function
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-30 ,DOI:10.1021/acsami.9b05554
Additionally, our GW hydrogel also possesses good perceived ability for external stimuli and subtle/large human motions. Most importantly, resistance memory function has been realized based on our GW hydrogel. ...
Oligonucleotide Cross-Linked Hydrogel for Recognition and Quantitation of MicroRNAs Based on a Portable Glucometer Readout
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-15 ,DOI:10.1021/acsami.8b21727
First, the amylase was encapsulated inside the DNA hydrogel and physically separated from its substrate of amylose, which was in a solution outside the hydrogel. After addition of the target miRNA, the activity of the MNAzyme was restored, which cuts off the substrate linker strand. ...
Antifreezing Heat-Resistant Hollow Hydrogel Tubes
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-08 ,DOI:10.1021/acsami.9b03892
However, the preparation of hollow hydrogel tubes still remains challenging because it normally requires templates or complex devices and it is hard to endow the hollow tubes with antifreezing heat-resistant capabilities. ...
Biomimetic Color-Changing Hierarchical and Gradient Hydrogel Actuators Based on Salt-Induced Microphase Separation
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-12 ,DOI:10.1021/acsami.9b17904
There have been more challenges for hydrogel actuators to meet the combined requirement of discoloration, complex deformation, and simple preparation. Structural coloration is widely used to fabricate discolored hydrogel via microrearrangement of photonic crystals in the hydrogel framework. ...
Polyvinyl Alcohol-Stabilized Liquid Metal Hydrogel for Wearable Transient Epidermal Sensors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-06 ,DOI:10.1021/acsami.9b16675
Furthermore, the dynamic cross-linking bonds between hydrogels and LMPs can rupture and coalesce reversibly in the hydrogel network, which endow the hydrogels with both electrically and mechanically self-healing ability. ...
PCL-MECM-Based Hydrogel Hybrid Scaffolds and Meniscal Fibrochondrocytes Promote Whole Meniscus Regeneration in a Rabbit Meniscectomy Model
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-22 ,DOI:10.1021/acsami.9b13611
Six months postimplantation we found that the PCL-hydrogel-MFCs group exhibited markedly better gross appearance and cartilage protection than the PCL scaffold and PCL-hydrogel groups. ...
Influence of Hydrolyzed Polyacrylamide Hydrogel Stiffness on Podocyte Morphology, Phenotype, and Mechanical Properties
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-28 ,DOI:10.1021/acsami.9b09337
In addition, the hydrogel properties can be easily modulated over a wide physiological range by controlling the cross-linker concentration. Finally, tuning the hydrogel properties is an effective strategy to control the cells function. ...
High-Strength, Self-Healable, Temperature-Sensitive, MXene-Containing Composite Hydrogel as a Smart Compression Sensor
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-04 ,DOI:10.1021/acsami.9b16078
The conductivity of the composite hydrogel was 1.092 S/m, which was about 15 times that of the control hydrogel without MXene. The potential of the composite hydrogel as a smart compression sensor was also verified by the conductivity tests. ...
Fabrication of Tough Hydrogel Composites from Photoresponsive Polymers to Show Double-Network Effect
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-26 ,DOI:10.1021/acsami.9b13746
Inspired by the toughening mechanism of double-network (DN) gels, tough hydrogel composites with a sandwich structure were fabricated from photoresponsive polymers. ...
Multiple-Responsive and Amphibious Hydrogel Actuator Based on Asymmetric UCST-Type Volume Phase Transition
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-07 ,DOI:10.1021/acsami.9b17159
Herein, we report a multiple-responsive UCST hydrogel actuator based on the complex of poly(acrylic acid) (PAAc) and poly(acrylamide) (PAAm). ...
Tough and Stretchable Dual Ionically Cross-Linked Hydrogel with High Conductivity and Fast Recovery Property for High-Performance Flexible Sensors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-17 ,DOI:10.1021/acsami.9b18796
The abundant Fe3+ and SO42– ions in the hydrogel can not only construct tough and strong dual ionic networks but also give the hydrogel high conductivity. ...
Effective Suppression of Oxidative Stress on Living Cells in Hydrogel Particles Containing a Physically Immobilized WS2 Radical Scavenger
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-10 ,DOI:10.1021/acsami.8b22223
We report a tungsten disulfide (WS2) nanosheet-immobilized hydrogel system that can inhibit oxidative stress on living cells. ...
Dynamic Creation of 3D Hydrogel Architectures via Selective Swelling Programmed by Interfacial Bonding
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-25 ,DOI:10.1021/acsami.9b05552
In this study, hydrogels are selected as the soft materials and hydrogel film/rigid substrate layer composites are fabricated to obtain a 3D hydrogel architecture based on swelling instability. ...
Injectable Citrate-Based Hydrogel as an Angiogenic Biomaterial Improves Cardiac Repair after Myocardial Infarction
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-11 ,DOI:10.1021/acsami.9b12043
Herein, we report an injectable, citrate-containing polyester hydrogel which can release citrate as a cell regulator via hydrogel degradation and simultaneously show sustained release of an encapsulated growth factor Mydgf. ...
Reversible Hydrogel Photopatterning: Spatial and Temporal Control over Gel Mechanical Properties Using Visible Light Photoredox Catalysis
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-28 ,DOI:10.1021/acsami.9b08853
Primarily, changes in the hydrogel’s physical properties, i.e., stiffness, toughness, etc., are achieved by modulating the network cross-linking chemistry. ...
Fabrication of Inverted High-Density DNA Microarrays in a Hydrogel
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-19 ,DOI:10.1021/acsami.9b07755
We produce a new generation of microarrays where highly ordered, purified oligos are inverted 3′-up, in a biocompatible soft hydrogel, and functional with respect to a wide variety of programable enzymatic reactions. ...
One-Step Preparation of a Highly Stretchable, Conductive, and Transparent Poly(vinyl alcohol)–Phytic Acid Hydrogel for Casual Writing Circuits
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-21 ,DOI:10.1021/acsami.9b12626
Herein, we have changed the traditional ingredient of poly(vinyl alcohol) (PVA) hydrogel by the addition of phytic acid (PA), which could yield a conductive hydrogel through one freeze–thaw cycle. ...
Double-Network Polyurethane-Gelatin Hydrogel with Tunable Modulus for High-Resolution 3D Bioprinting
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-29 ,DOI:10.1021/acsami.9b10784
Herein, a series of biodegradable polyurethane (PU)-gelatin hydrogel with tunable mechanical properties and degradation rates were developed as the bioink. The PU-gelatin hydrogel demonstrated good printability in 24–31 °C and could print a complicated structure such as the nose-shaped construct. ...
Multiresponsive and Self-Healing Hydrogel via Formation of Polymer–Nanogel Interfacial Dynamic Benzoxaborole Esters at Physiological pH
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-15 ,DOI:10.1021/acsami.9b16139
The dynamic nature of benzoxaborole esters endowed the hydrogel with moldability and self-healing ability after disruption. Moreover, the hydrogel showed multiresponsiveness toward pH, sugar, adenosine triphosphate (ATP), hydrogen peroxide (H2O2), and temperature. ...
Dispersed Association of Single-Component Short-Alkyl Chains toward Thermally Programmable and Malleable Multiple-Shape Hydrogel
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-11 ,DOI:10.1021/acsami.9b16205
This paper reports a type of thermally programmable and malleable multiple-shape hydrogel. The network of this hydrogel is solely composed of a type of polyvinyl alcohol derivative, which is synthesized by substituting hydroxyl groups of polyvinyl alcohol with single-component octyl chains. ...
Black Phosphorus Hydrogel Scaffolds Enhance Bone Regeneration via a Sustained Supply of Calcium-Free Phosphorus
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-11 ,DOI:10.1021/acsami.8b21179
Herein, a black phosphorus nanosheet (BPN)-based hydrogel platform was developed, and the BPNs were used to stably and mildly provide phosphorus. The hydrogel was fabricated by photo-crosslinking of gelatin methacrylamide, BPNs, and cationic arginine-based unsaturated poly(ester amide)s. ...
Integrated Hydrogel Platform for Programmed Antitumor Therapy Based on Near Infrared-Triggered Hyperthermia and Vascular Disruption
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-10 ,DOI:10.1021/acsami.9b05536
Moreover, the biosafety and eco-friendliness of the hydrogel platform pave the way toward clinical applications. ...
Tunable Dual Temperature–Pressure Sensing and Parameter Self-Separating Based on Ionic Hydrogel via Multisynergistic Network Design
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-28 ,DOI:10.1021/acsami.9b05214
Herein, a functional ionic hydrogel-base flexible sensor was successfully prepared by integrating the thermal-sensitive N-isopropylacrylamide (NIPAAm) into another conductive double-network hydrogelbased on polyvinyl alcohol–graphene oxide (PVA–GO) and polyacrylic acid–Fe3+ (PAA–Fe3+). ...
A Novel Conductive and Micropatterned PEG-Based Hydrogel Enabling the Topographical and Electrical Stimulation of Myoblasts
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-16 ,DOI:10.1021/acsami.9b16005
In this study, we designed a cell-adhesive poly(ethylene glycol) (PEG)-based hydrogel that simultaneously provides topographical and electrical stimuli to C2C12 myoblasts. ...
A pH-Triggered, Self-Assembled, and Bioprintable Hybrid Hydrogel Scaffold for Mesenchymal Stem Cell Based Bone Tissue Engineering
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-25 ,DOI:10.1021/acsami.8b19094
The CMCh-ACP hydrogel exhibits excellent biocompatibility and effectively supports MSC proliferation and cell adhesion. ...
Highly Stretchable and Transparent Double-Network Hydrogel Ionic Conductors as Flexible Thermal–Mechanical Dual Sensors and Electroluminescent Devices
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-23 ,DOI:10.1021/acsami.9b01989
Such highly optical transparency and elasticity endow the hydrogel-phosphor composites with promising luminescent properties. The multifunctional ionic hydrogel can be used as soft conductors for application in flexible devices such as ionic skin for wearable sensors and luminescence display. ...
Creating an Interface: Rendering a Double-Network Hydrogel Lubricious via Spontaneous Delamination
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-02 ,DOI:10.1021/acsami.9b07387
An alginate-rich “skin” layer is spontaneously delaminated due to the mechanical instability and osmotic mismatch between the swollen double-network hydrogel matrix and the rigid “skin” layer. ...
Mussel-Inspired Injectable Hydrogel Adhesive Formed under Mild Conditions Features Near-Native Tissue Properties
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-16 ,DOI:10.1021/acsami.9b16465
This strategy features a minor, yet impactful modification of biopolymers, which gives access to collective properties of an ideal injectable hydrogel adhesive. ...
Conductive Hydrogen Sulfide-Releasing Hydrogel Encapsulating ADSCs for Myocardial Infarction Treatment
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-12 ,DOI:10.1021/acsami.9b01886
The hydrogel exhibited adhesive property to ensure a stable anchoring to the wet and beating hearts. ...
Cell-Laden Electroconductive Hydrogel Simulating Nerve Matrix To Deliver Electrical Cues and Promote Neurogenesis
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-13 ,DOI:10.1021/acsami.9b05520
Next, cell-laden collagen–PPy hybrid hydrogel microfibers with highly oriented microstructures were fabricated via a microfluidic chip. ...
Adhesive Tough Magnetic Hydrogels with High Fe3O4 Content
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-28 ,DOI:10.1021/acsami.8b20937
The hydrogel can be bonded to hydroxyl-rich hard and soft surfaces. Magnetic hydrogelwith polydimethylsiloxane (PDMS) coating exhibits excellent underwater performance. The bonding between magnetic hydrogel and PDMS is very stable even under cyclic loading. ...
Amino Acid-Modified Conjugated Oligomer Self-Assembly Hydrogel for Efficient Capture and Specific Killing of Antibiotic-Resistant Bacteria
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-15 ,DOI:10.1021/acsami.9b02643
Interestingly, when the hydrogel was put on a model surface, a piece of cloth, it also is able to selectively kill MRSA with low cell cytotoxicity. ...
Carrier-Free Supramolecular Hydrogel Composed of Dual Drugs for Conquering Drug Resistance
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-09 ,DOI:10.1021/acsami.9b12530
Our study provides a new strategy for fabricating a carrier-free supramolecular hydrogel to overcome drug resistance, which might open up an alternative avenue for the tumor combinational therapy. ...
Sustained Release of Exendin 4 Using Injectable and Ionic-Nano-Complex Forming Polymer Hydrogel System for Long-Term Treatment of Type 2 Diabetes Mellitus
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-18 ,DOI:10.1021/acsami.8b19669
Given that the Ex-4 release occurs after the complex releases from the hydrogel, the periods of Ex-4 release and hydrogel maintenance may be similar. The present system showed a considerably prolonged Ex-4 release. ...
Spatial Patterning of Molecular Cues and Vascular Cells in Fully Integrated Hydrogel Channels via Interfacial Bioorthogonal Cross-Linking
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-26 ,DOI:10.1021/acsami.9b04383
Injecting an aqueous solution of a bisTCO cross-linker into a reservoir of tetrazine-modified hyaluronic acid (HA-Tz), while simultaneously drawing the syringe needle through the reservoir, yielded a cross-linked hydrogel channel that was mechanically robust. ...
Direct Current-Powered High-Performance Ionic Hydrogel Strain Sensor Based on Electrochemical Redox Reaction
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-24 ,DOI:10.1021/acsami.9b06523
The slow H+ reduction rate and chemical component change within the hydrogel account for their low sensitivity and signal-to-noise ratio (SNR). ...
Transparent, Antifreezing, Ionic Conductive Cellulose Hydrogel with Stable Sensitivity at Subzero Temperature
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-23 ,DOI:10.1021/acsami.9b15849
The concentrated BzMe3NOH solution in the CCH matrix endowed the hydrogel with transparency, ionic conductivity, and freeze tolerance. CCH maintained transparency over 90% and stable mechanical properties in the temperatures from −27.8 to 62.1 °C. ...
Injectable and Quadruple-Functional Hydrogel as an Alternative to Intravenous Delivery for Enhanced Tumor Targeting
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-11 ,DOI:10.1021/acsami.9b10182
To address this limitation, we report a new systemic delivery method utilizing injectable and quadruple-functional hydrogels to improve targeting efficiency through passive, active, and magnetic targeting, and hydrogel-controlled sustained release. ...
Stimuli Responsive, Self-Sustainable, and Self-Healable Functionalized Hydrogel with Dual Gelation, Load-Bearing, and Dye-Absorbing Properties
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-17 ,DOI:10.1021/acsami.9b01129
The hydrogel provides an excellent platform to study dynamic phase behavior within a supramolecular network as it exhibits transformation from a fibrillar opaque hydrogel to a transparent hydrogel upon heating. ...
Direct Patterning of Highly Conductive PEDOT:PSS/Ionic Liquid Hydrogel via Microreactive Inkjet Printing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-27 ,DOI:10.1021/acsami.9b12069
Here, microreactive inkjet printing (MRIJP) is utilized to pattern various 2D and 3D structures of PEDOT:PSS/IL hydrogel by in-air coalescence of PEDOT:PSS and ionic liquid (IL). ...
High-Resolution 3D Printing of Stretchable Hydrogel Structures Using Optical Projection Lithography
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-27 ,DOI:10.1021/acsami.9b19431
We show that strain and the elastic modulus of printed structures can be tuned based on the hydrogelcomposition, cross-linker and photoinitiator concentrations, and laser light intensity. ...
Smart Responsive Luminescent Aptamer-Functionalized Covalent Organic Framework Hydrogel for High-Resolution Visualization and Security Protection of Latent Fingerprints
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-15 ,DOI:10.1021/acsami.9b18251
This effect endows potential applications of tunable luminescent COFs based hydrogel as an invisible security probe for imaging, recording, storage, and security of latent fingerprint information. ...
Strong Wet Adhesion of Tough Transparent Nanocomposite Hydrogels for Fast Tunable Focus Lenses
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-12 ,DOI:10.1021/acsami.9b02556
The strong wet adhesion between two tough hydrogel films can be realized by introducing chemical bridging across the hydrogel–hydrogel interface, while the interfacial adhesion energy and shearing adhesion strength are up to 2216 J m–2 and 385 N m–1, respectively. ...
Fluorescence Enhancement from Nitro-Compound-Sensitive Bacteria within Spherical Hydrogel Scaffolds
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-05 ,DOI:10.1021/acsami.9b02262
Here, we report that nitro compounds were detected by the bacterial sensor based on hydrogelmicrobeads as a platform. ...
Self-Assembly of Metallo-Nucleoside Hydrogels for Injectable Materials That Promote Wound Closure
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-22 ,DOI:10.1021/acsami.9b02265
Importantly, the rapid switching between the sol and gel states for this supramolecular hydrogel, as a response to shear stress, enables 3D printing of a flexible medical patch made from the C–B–C•Ag+ hydrogel. The C–B–C•Ag+ hydrogel was used to promote the closure of burn wounds in a mouse model. ...
Influence of Loading Conditions and Temperature on Static Friction and Contact Aging of Hydrogels with Modulated Microstructures
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-31 ,DOI:10.1021/acsami.9b14283
occurring at the migrating hydrogel interface are of relevance. ...
Ultrastretchable Wearable Strain and Pressure Sensors Based on Adhesive, Tough, and Self-healing Hydrogels for Human Motion Monitoring
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-05 ,DOI:10.1021/acsami.9b08369
Here, casein sodium salt from bovine milk (sodium casein, SC) and polydopamine (PDA, inspired by mussels) were successfully introduced into the polyacrylamide (PAAm) hydrogel system to fabricate a tough and adhesive SC–PDA hydrogel. ...
Cucurbit[7]uril-Carbazole Two-Photon Photoinitiators for the Fabrication of Biocompatible Three-Dimensional Hydrogel Scaffolds by Laser Direct Writing in Aqueous Solutions
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-04 ,DOI:10.1021/acsami.8b15011
The formation of the host–guest complex increases the two-photon absorption cross-section about five times, and improves the water solubility required as the photoinitiator for hydrogel fabrication. ...
Alginate Hydrogel Modified with a Ligand Interacting with α3β1 Integrin Receptor Promotes the Differentiation of 3D Neural Spheroids toward Oligodendrocytes in Vitro
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-29 ,DOI:10.1021/acsami.8b19438
The porosity of the hydrogel was optimized by varying the alginate concentrations and then characterized by scanning electronic microscopy (SEM). ...
Supramolecular Fabrication of Complex 3D Hollow Polymeric Hydrogels with Shape and Function Diversity
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-12 ,DOI:10.1021/acsami.9b17440
By placing a Ca2+ included gelatin core into the solution of alginate, hydrogel shell could be formed along with the shape of the gelatin core via coordination between alginate chains and Ca2+ diffused from gelatin. The hollow hydrogel could finally be obtained by dissolving the gelatin core. ...
Self-Healable Hydrogel Electrolyte toward High-Performance and Reliable Quasi-Solid-State Zn–MnO2 Batteries
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-14 ,DOI:10.1021/acsami.9b13553
The improvement is attributed to efficient suppression of the dendrite growth and side reactions at the electrode/electrolyte by the hydrogel electrolyte. ...
Injectable, Biodegradable, Thermosensitive Nanoparticles-Aggregated Hydrogel with Tumor-Specific Targeting, Penetration, and Release for Efficient Postsurgical Prevention of Tumor Recurrence
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-22 ,DOI:10.1021/acsami.9b01987
Collectively, the reported multifunctional nanoparticles self-aggregated hydrogel system possesses great potential for efficient postsurgical prevention of tumor recurrence. ...
Rapid Dewatering and Consolidation of Concentrated Colloidal Suspensions: Mature Fine Tailings via Self-Healing Composite Hydrogel
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-04 ,DOI:10.1021/acsami.9b05692
The resultant composite hydrogel demonstrates an excellent dewatering performance so that over 50% of water could be rapidly released within 30 min by vacuum filtration. ...
Combination of the Silver–Ethylene Interaction and 3D Printing To Develop Antibacterial Superporous Hydrogels for Wound Management
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-04 ,DOI:10.1021/acsami.9b14090
In vivo experiments demonstrated that the AgNP-cross-linked superporous hydrogel dressings could promote the healing of the infected wounds and restrain scar tissue formation. ...
Self-Assembly, Tunable Hydrogel Properties, and Selective Anti-Cancer Activity of a Carnosine-Derived Lipidated Peptide
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-03 ,DOI:10.1021/acsami.9b09065
In addition, hydrogelation was observed and the gel modulus was measured in different aqueous media conditions, revealing tunable hydrogel modulus depending on the concentration and nature of the aqueous phase. ...
Correction to “Janus Nanocomposite Hydrogels for Chirality-Dependent Cell Adhesion and Migration”
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-14 ,DOI:10.1021/acsami.9b09747
Experimental procedures of the synthesis, functionalization of PMOs and zeolites L; analytic characterization data (SEM, IR) and physicochemical properties of functionalized PMOs and zeolites L; analytic characterization data of alginate and NC hydrogel scaffolds; SEM images of NC hydrogelscaffolds; ...
Control of Dissipation Sources: A Central Aspect for Enhancing the Mechanical and Mechanobiological Performances of Hydrogels
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-16 ,DOI:10.1021/acsami.9b15450
While fluid frictional drag is playing a significant role in this phenomenon, the flow-dependent source of dissipation is mostly overlooked in the design of hydrogel scaffolds. ...
One-Pot and One-Step Fabrication of Salt-Responsive Bilayer Hydrogels with 2D and 3D Shape Transformations
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-06 ,DOI:10.1021/acsami.9b06691
These two-dimensional hydrogel sheets exhibited complex and reversible three-dimensional shape transformations due to the different bending behaviors of the patterned hydrogel stripes under the action of an external stimulus. ...
Displacement Affinity Release of Antibodies from Injectable Hydrogels
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-16 ,DOI:10.1021/acsami.9b12572
To rapidly tune release profiles of bioactive Abs, we developed a biophysical interaction system within a neutravidin modified poly(carboxybetaine) hydrogel (pCB-NT) that tunes release rates of desthiobiotinylated Abs (D-Abs) using a constant hydrogel and D-Ab combination. ...
Peptide-/Drug-Directed Self-Assembly of Hybrid Polyurethane Hydrogels for Wound Healing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-24 ,DOI:10.1021/acsami.9b13708
This peptide-/drug-directed self-assembly of hybrid polyurethane hydrogel could be used as a promising platform for tissue-engineering scaffold and biomedical application. ...
Entanglement-Driven Adhesion, Self-Healing, and High Stretchability of Double-Network PEG-Based Hydrogels
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-25 ,DOI:10.1021/acsami.9b14348
Combining the intrinsic biocompatibility of PEG and rational design for tuning the hydrogel network properties, we exemplarily demonstrated that this hydrogel can be used as a three-dimensional matrix for cell culture or as a tissue adhesive for wound healing. ...
Plastic-like Hydrogels with Reversible Conversion of Elasticity and Plasticity and Tunable Mechanical Properties
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-24 ,DOI:10.1021/acsami.9b14158
However, the deformed PHs could return to their original size and softness of hydrogel when immersed in pure water, which is a kind of shape-memory effect. ...
Nanocomposite Hydrogels with Optic–Sonic Transparency and Hydroacoustic-Sensitive Conductivity for Potential Antiscouting Sonar
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-24 ,DOI:10.1021/acsami.9b04463
Inversely, upon removing the hydroacoustic signals, the Li+ ions could be readsorbed again by the clay nanosheets; as a result, the conductivity of the nanocomposite hydrogel decreases again. ...
Multifunctional Photo- and Magnetoresponsive Graphene Oxide–Fe3O4 Nanocomposite–Alginate Hydrogel Platform for Ice Recrystallization Inhibition
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-25 ,DOI:10.1021/acsami.9b02887
As a typical application, we show that this GO–Fe3O4 nanocomposite–alginate hydrogel platform can successfully enable low-cryoprotectant, high-quality vitrification of stem cell-laden hydrogels. ...
Nucleic Acid-Based Dual Cross-Linked Hydrogels for in Situ Tissue Repair via Directional Stem Cell Migration
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-17 ,DOI:10.1021/acsami.9b10074
Here we report the design of a DNA-based hydrogel as a drug delivery platform for the sustained release of a promising chemoattractant, SDF-1α. The hydrogel is composed of chemically cross-linked DNA strands, which are bridged via silicate nanodisks (nSi). ...
Molecularly Imprinted Sites Translate into Macroscopic Shape-Memory Properties of Hydrogels
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-03 ,DOI:10.1021/acsami.9b06598
These imprinted hydrogel matrices show selective recovery of the stiff properties upon binding the respective electron acceptor units to the imprinted sites. ...
Pectin Methacrylate (PEMA) and Gelatin-Based Hydrogels for Cell Delivery: Converting Waste Materials into Biomaterials
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-22 ,DOI:10.1021/acsami.9b00154
To endow this hydrogel matrix with cell differentiation and cell spreading properties, we have also incorporated thiolated gelatin into the system. ...
Rebuilding Postinfarcted Cardiac Functions by Injecting TIIA@PDA Nanoparticle-Cross-linked ROS-Sensitive Hydrogels
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-10 ,DOI:10.1021/acsami.8b20158
In this research, an ROS-sensitive injectable hydrogel strengthened by self-nanodrugs was constructed. A hyperbranched ROS-sensitive macromer (HB-PBAE) with multiacrylate end groups was synthesized through dynamic controlled Michael addition. ...
Hydrogel Bioink with Multilayered Interfaces Improves Dispersibility of Encapsulated Cells in Extrusion Bioprinting
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-16 ,DOI:10.1021/acsami.9b09782
Cells in a hydrogel bioink that features low viscosity tend to settle to the bottom of the bioink reservoir, and as such, their bioprintability is hindered by association with the inhomogeneous cellularized structures that are deposited. ...
Hydrogelation Landscape Engineering and a Novel Strategy To Design Radically Induced Healable and Stimuli-Responsive Hydrogels
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-14 ,DOI:10.1021/acsami.9b02592
It is deduced that the generation of terpyridine-based radicals enhances the intermolecular hydrogen bonding and π–π interaction of molecules in a hydrogel matrix, which is responsible for the self-healing ability. ...
Shape Morphing of Hydrogels in Alternating Magnetic Field
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-31 ,DOI:10.1021/acsami.9b05742
We design the distributing pattern of magnetic hydrogel strips on an elastomer substrate to realize various two-dimensional and three-dimensional shapes such as heart-shape, truss, tube, and helix. ...
Optimized Association of Short Alkyl Side Chains Enables Stiff, Self-Recoverable, and Durable Shape-Memory Hydrogel
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-15 ,DOI:10.1021/acsami.9b06716
This work reports a self-healing and shape-memory hydrogel integrating multiple mechanical properties. The network configuration is featured as entangled networks cross-linked by distributed association of very short alkyl chains (hexyl, six carbons). ...
Magnetic Responsive PVA Hydrogels for Remote Modulation of Protein Sorption
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-29 ,DOI:10.1021/acsami.9b03146
The noninvasive regulation of protein sorption-released mechanisms was achieved by ON/OFF magnetic field switches, suggesting the possible influence of magnetic-induced hydrogel shrinking effect and changes of surface wettability on protein sorption. ...
Homogeneous and Real Super Tough Multi-Bond Network Hydrogels Created through a Controllable Metal Ion Permeation Strategy
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-31 ,DOI:10.1021/acsami.9b18620
The real robust tensile strength of this hydrogel originates from the effective energy dissipation of the homogeneous PAA-Fe3+ cross-links, and the high water content ensures a large elongation at break. Furthermore, the hydrogel also has pH-responsive and shape-memory properties. ...
Multiresponsive Supramolecular Luminescent Hydrogels Based on a Nucleoside/Lanthanide Complex
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-06 ,DOI:10.1021/acsami.9b17236
Herein, we realize the creation of a luminescent hydrogel assembled from lanthanides and nucleosides. Nucleosides, the essential components of nucleic acids, functioning as the ligands, successfully chelate with lanthanides and form complexes in water. ...
Highly Tough Hydrogels with the Body Temperature-Responsive Shape Memory Effect
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-11-08 ,DOI:10.1021/acsami.9b14756
Besides, the hydrogel with 60 mol % PEA shows an excellent body temperature-responsive shape memory behavior with almost 100% shape fixity and shape recovery. ...
Hydrogel-Mediated Sustained Systemic Delivery of Mesenchymal Stem Cell-Derived Extracellular Vesicles Improves Hepatic Regeneration in Chronic Liver Failure
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-03 ,DOI:10.1021/acsami.9b10126
In vivo tracking of the labeled EVs revealed that the accumulation of EVs in the liver was extended by hydrogel-mediated delivery for 1 month. ...
Dynamic Supramolecular Hydrogels Spanning an Unprecedented Range of Host–Guest Affinity
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-01 ,DOI:10.1021/acsami.8b22151
This work thus informs a role for affinity in dictating supramolecular hydrogel properties by quantifying and isolating this feature over an unprecedented range. ...
DNA-Based Hybrid Hydrogels Sustain Water-Insoluble Ophthalmic Therapeutic Delivery against Allergic Conjunctivitis
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-15 ,DOI:10.1021/acsami.9b08652
Given this performance, demonstrable biocompatibility, and biodegradability of DNA hydrogel, the HDNA-based ophthalmic therapeutic delivery system enables novel treatment paradigms, which will have widespread applications in the treatment of various eye diseases. ...
POSS-Induced Dynamic Cross-Links Produced Self-Healing and Shape Memory Physical Hydrogels When Copolymerized with N-Isopropyl acrylamide
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-06-26 ,DOI:10.1021/acsami.9b06672
NIPAm-POSS copolymers are unentangled and exhibit a thermoplastic and thermoresponsive hydrogelbehavior (Romo-Uribe; ; Albanil, Eur. Polym. J. 2018, 99, 350−360). ...
Bioinspired, Injectable, Quaternized Hydroxyethyl Cellulose Composite Hydrogel Coordinated by Mesocellular Silica Foam for Rapid, Noncompressible Hemostasis and Wound Healing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-10 ,DOI:10.1021/acsami.9b08799
Inspired by the coordinated primarily blood clot formation and secondly coagulation cascade activation in natural hemostasis process, an injectable, quaternized hydroxyethyl cellulose/mesocellular silica foam (MCF) hydrogel sponge (QHM) for both hemorrhage control and antibacterial activities were prepared ...
Design of a Peptide-Based Electronegative Hydrogel for the Direct Encapsulation, 3D Culturing, in Vivo Syringe-Based Delivery, and Long-Term Tissue Engraftment of Cells
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-13 ,DOI:10.1021/acsami.9b12152
Herein, we develop a negatively charged fibrillar hydrogel based on the de novo-designed self-assembling peptide AcVES3-RGDV. Cells are easily encapsulated during the triggered self-assembly of the peptide leading to gel formation. ...
Mechanically Stable C2-Phenylalanine Hybrid Hydrogels for Manipulating Cell Adhesion
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-08-01 ,DOI:10.1021/acsami.9b08655
Rheological studies confirmed the superiority of the hybrid hydrogels over the neat hydrogel, where LPF-CMDH3 exhibited the best mechanical properties with an improved elastic modulus of 11 654 Pa over 1518 and 140 Pa for LPF-AD4.5 and LPF, respectively. ...
Mechanically Biomimetic Gelatin–Gellan Gum Hydrogels for 3D Culture of Beating Human Cardiomyocytes
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-30 ,DOI:10.1021/acsami.8b22343
One potential material for this purpose is gellan gum (GG), a biocompatible and mechanically tunable hydrogel. However, GG alone does not provide attachment sites for cells to thrive in 3D. ...
Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-06 ,DOI:10.1021/acsami.9b13905
It is demonstrated that the hydrogel scaffold enables the formation, growth, and natural release of HepaRG spheroids with sizes up to millimeters. This strategy may be suitable to develop a series of new bioink materials based on peptides and other supramolecular polymers for 3D bioprinting. ...
Conductive Self-Healing Nanocomposite Hydrogel Skin Sensors with Antifreezing and Thermoresponsive Properties
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-31 ,DOI:10.1021/acsami.9b20254
With growing interest in flexible and wearable devices, the demand for nature-inspired soft smart materials, especially intelligent hydrogels with multiple perceptions toward external strain and temperatures to mimic the human skin, is on the rise. ...
Biohybrid Hydrogel and Aerogel from Self-Assembled Nanocellulose and Nanochitin as a High-Efficiency Adsorbent for Water Purification
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-12-03 ,DOI:10.1021/acsami.9b15139
A simple and novel method, self-assembly of nanocellulose and nanochitin, was developed to produce high-efficiency and versatile biohybrid hydrogel (BHH) and aerogel (BHA) for water purification. ...
High-Strength, Self-Adhesive, and Strain-Sensitive Chitosan/Poly(acrylic acid) Double-Network Nanocomposite Hydrogels Fabricated by Salt-Soaking Strategy for Flexible Sensors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-10-02 ,DOI:10.1021/acsami.9b15817
In addition, benefiting from the abundant free ions from strong electrolytes, the flexible hydrogel sensors demonstrated stable conductivity and strain sensitivity, which could monitor both large human motions and subtle motions. ...
Tunable Three-Dimensional Nanostructured Conductive Polymer Hydrogels for Energy-Storage Applications
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-01-17 ,DOI:10.1021/acsami.8b19180
When used as supercapacitor electrodes, the TB-doped PPy hydrogel reaches maximal specific capacitance of 649 F/g at the current density 1 A/g. The result shows that PPy nanostructured hydrogels can be tuned for potential applications in next-generation energy-storage materials. ...
Flexible Hydrogel Electrolyte with Superior Mechanical Properties Based on Poly(vinyl alcohol) and Bacterial Cellulose for the Solid-State Zinc–Air Batteries
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-22 ,DOI:10.1021/acsami.9b00758
Here, we introduce flexible bacterial cellulose (BC)/poly(vinyl alcohol) (PVA) composite hydrogelelectrolytes (BPCE) based on bacterial cellulose (BC) microfibers and poly(vinyl alcohol) (PVA) by an in situ synthesis. ...
Metallohydrogel with Tunable Fluorescence, High Stretchability, Shape-Memory, and Self-Healing Properties
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-10 ,DOI:10.1021/acsami.9b06177
A reversible system consisting of Fe3+/H+, was implemented to control the shape of the Al-hydrogel, endowing the Al-hydrogel with shape-memory ability. ...
Stretchable and Self-Healable Conductive Hydrogels for Wearable Multimodal Touch Sensors with Thermoresponsive Behavior
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-07-08 ,DOI:10.1021/acsami.9b04440
Incorporation of LCST polymers into high-end hydrogel systems may contribute to the development of temperature-dependent soft electronics that can be applied in smart windows. ...
Protected Amino Acid–Based Hydrogels Incorporating Carbon Nanomaterials for Near-Infrared Irradiation-Triggered Drug Release
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-03-27 ,DOI:10.1021/acsami.9b02482
Circular dichroism and molecular dynamics simulations demonstrated that the hydrogel formation was mainly driven by aromatic interactions. Finally, a model hydrophilic drug (l-ascorbic acid) was loaded into the hybrid hydrogels at a high concentration. ...
Self-Assembled Injectable Nanocomposite Hydrogels Coordinated by in Situ Generated CaP Nanoparticles for Bone Regeneration
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-05-01 ,DOI:10.1021/acsami.9b03173
Here, we developed an injectable nanocomposite hydrogel by in situ growth of CaP nanoparticles (ICPNs) during the free-radical polymerization of dimethylaminoethyl methacrylate (DMAEMA) and 2-hydroxyethyl methacrylate (HEMA) matrix (PDH) for bone regeneration. ...
Multiple Weak H-Bonds Lead to Highly Sensitive, Stretchable, Self-Adhesive, and Self-Healing Ionic Sensors
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-02-13 ,DOI:10.1021/acsami.8b20380
More importantly, the ternary hydrogel exhibits high strain sensitivity especially under subtle strains with a gauge factor of 2.0, which is close to the theoretical value of the ionic hydrogel sensors; an extremely large workable range of strain (0.05–2100%); and a low operating voltage 0.07 V. ...
Electroassembly of Chitin Nanoparticles to Construct Freestanding Hydrogels and High Porous Aerogels for Wound Healing
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-09-12 ,DOI:10.1021/acsami.9b13063
Interestingly, the electroassembly of chitin nanoparticles is completely reversible, suggesting the physical assembly feature of the freestanding hydrogel. By using supercritical CO2 drying and freeze-drying, chitin aerogels and cryogels can be facilely obtained. ...
Mechanical Property of Hydrogels and the Presence of Adipose Stem Cells in Tumor Stroma Affect Spheroid Formation in the 3D Osteosarcoma Model
ACS Applied Materials & Interfaces (IF 8.456) Pub Date : 2019-04-15 ,DOI:10.1021/acsami.8b22724
Taken together, the GG–silk fibroin-blended spongy-like hydrogel is envisioned as an alternative low-cost platform for 3D cancer modeling. ...






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